association	dataset	threshold value	standardized value
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAL29	CCLE Cell Line Gene CNV Profiles	1.0	1.52255
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr20_34551580_T_C_b38	GTEx eQTL 2025	1.0	5.08129
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128712
A549_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159901
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04586
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Melanoma	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.27104
K562_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214913
EFO27	DepMap CRISPR Gene Dependency	1.0	2.89344
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.39958
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nucleoli fibrillar center	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15379
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01549	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.02863
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48734
GSE240468_3_v_2_nfyc_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LMSU	DepMap CRISPR Gene Dependency	1.0	2.16728
TSC1-TSC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
Acute Myeloid Leukemia_LAML_TCGA-AB-2835-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Storage tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IV-01A-22R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fallopiantube_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.885761
K562_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233874
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
2269_DNA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.643719
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.928424
GTEX-X4EP-0726-SM-3P5YJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02643
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07822
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP(20:3(5Z,8Z,11Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Rhoptry neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP(16:0/20:1(11Z)) 	HMDB Metabolites of Enzymes	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223301
PI(20:3(8Z,11Z,14Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	118.232
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.5147
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056943
HT55	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251293
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201345
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13095
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
MCF7_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139582
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34782
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51147
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943381
SETDB1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GQ1c (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22443
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.9133
THAP11-20581084-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVSAHO	CCLE Cell Line Gene CNV Profiles	1.0	2.06476
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14772
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(16:0/22:2(13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Baicalin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161996
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.25728
Ganglioside GT2 (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.792089
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medullary thyroid carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
Malaria	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.939794
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.05229
MBD4	ENCODE Transcription Factor Targets	1.0	null
K562_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230472
K562_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162619
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Ganglioside GM1 (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
ZFP42-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.51103
Cer(d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.889295
Ganglioside GT1b (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43499
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02617
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10078
K562_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198968
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	0.957265
K562_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145919
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28785
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.0303
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0726-SM-48TZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827431
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859603
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
94T778	DepMap CRISPR Gene Dependency	1.0	4.2977
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242432
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864043
J82	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
BC3C	DepMap CRISPR Gene Dependency	1.0	2.58699
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_TMP195_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136538
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16942
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE236511_1_v_0_ngfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018895
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.911
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18599
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51033
Hyperphosphatasia with impaired intellectual development syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
PIP(20:3(8Z,11Z,14Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41Q-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022933
HMS3745G19	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
SDAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27909
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POGK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66649
Ganglioside GT3 (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
PI(18:2(9Z,12Z)/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
CHST6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50155
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191568
GSE186280_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PI(20:0/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44747
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97773
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7822
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Basal part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
PIP(18:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
K562_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0365226
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29502
A549_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132368
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06881
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345254
USF1	ENCODE Transcription Factor Targets	1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61392
PI(16:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
A549_ITSA-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136988
Ganglioside GD1b (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
PIP(20:4(8Z,11Z,14Z,17Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OCI-LY-19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WRHU-0626-SM-3MJFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04452
Metanephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00842
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169298
NMuMg cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.639
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4423
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130598
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_2_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2291	DepMap CRISPR Gene Dependency	1.0	2.5693
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.3961
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76262
PI(20:2(11Z,14Z)/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
Bacterial invasion of epithelial cells	KEGG Pathways 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5745
Ganglioside GD1a (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Cer(d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
liposaccharide metabolic process	GO Biological Process Annotations 2015	1.0	null
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54375
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.7301
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15331
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93726
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XPT6-2126-SM-4B66P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978898
Ganglioside GD1b (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-U8T8-1226-SM-4E3IH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09104
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27202
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR3C1-23031785-PC12-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
PMC7254680__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.62528
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD3 (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ZM 447439_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134273
Ganglioside GM1 (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25439
GTEX-QCQG-1626-SM-48U26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09716
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10409
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LN215	CCLE Cell Line Gene Expression Profiles	1.0	1.49089
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893255
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.9948
A549_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208506
STOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19772
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GM3 (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0390752
PIP2(16:0/22:4(10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9051
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32398
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054092
Ganglioside GT1c (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.268
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5538
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1915	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84735
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216394
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1137
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BARX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30285
Bark	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
MDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11842
primary motor cortex (area M1, area 4)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.856473
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221054
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125032
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55341
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936532
Pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-KD-A5QU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Peptidase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
membrane lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
Trihexosylceramide (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HaCaT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10018
Pollen tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.37
RB-55-KL42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236542
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3014
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3064-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PPP2R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22978
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015615
NCIH520	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35299
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179069
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.948095
MCF7_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229948
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1071
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
RERFLCAI	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71387
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250548
Glucosylceramide (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GM2 (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Crizotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105426
Neurotrophin signaling pathway	KEGG Pathways 2026	1.0	null
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
Galactosylceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD3 (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.1884
PI(20:3(5Z,8Z,11Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	2.49686
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNOS-1626-SM-3NMA4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06853
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3181
PIP(20:3(5Z,8Z,11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00935132
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K4-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115951
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SM(d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.034
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276623
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36024
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Ganglioside GT3 (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C7-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242268
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.202319
kidney disease	GWASdb SNP-Disease Associations	1.0	0.937304
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2826-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Basal plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
Egg chorion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.005
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282364
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.982009
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151977
DNAJC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06139
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.13768
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018619
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490035
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012448
CHD1	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GD1b (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
Iridogoniodysgenesis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.7
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PIP2(16:1(9Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3325
Ganglioside GQ1c (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135350_3_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3765
UMUC3	DepMap CRISPR Gene Dependency	1.0	3.27964
Waist-to-hip ratio adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26513
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.16135
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42335
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49675
TCR signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.812
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC4006	CCLE Cell Line Gene Expression Profiles	-1.0	-2.00025
Glucosylceramide	HMDB Metabolites of Enzymes	1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218276
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86174
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30802
PAX5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
PIP2(18:1(9Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
hsa-miR-370	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125229
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT2 (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_73_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP(18:1(11Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cingulate gyrus, frontal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.929427
Ganglioside GD1b (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0605
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT3 (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913749
Glucosylceramide (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12715
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE85995_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.03415
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC-95 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
OCILY19	CCLE Cell Line Gene Mutation Profiles	1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840808
PI(20:4(8Z,11Z,14Z,17Z)/20:0)	HMDB Metabolites of Enzymes	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.11997
PIP(18:1(15Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191943
CCNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61522
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.884522
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3199
MCF7_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128556
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56101
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137778
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80667
TYK2_knockdown_176_GSE44652	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.33659
PI(20:0/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197449
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
subiculum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.843299
Ganglioside GT2 (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
Pt-K2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.852461
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267595
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4836
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alveolar cell type II	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
Ganglioside GM2 (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
fat_x1.V2	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.895201
not applicable_asthma_GSE43696_369_mouse_bronchial epithelial cell	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27667
Ganglioside GD1b (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GD1a (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
PI(16:0/22:4(7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(22:3(10Z,13Z,16Z)/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.300173
Tetrahexosylceramide (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.974757
AB-21-VE32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305293
MCF7_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156648
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98273
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29332
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52699
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16535
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365687
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017398
hsa-miR-3150a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
MYBL2	ENCODE Transcription Factor Targets	1.0	null
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	1.0	0.914004
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Cer(d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV_48Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.79594
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954569
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25199
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.24339
PI(20:4(5Z,8Z,11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Ganglioside GT3 (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07778
Galabiosylceramide (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
TYK2_knockdown_35_GDS4754	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.33659
gpi-anchor transamidase complex	GO Cellular Component Annotations 2015	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	165.818
SOX9	ChEA Transcription Factor Targets	1.0	null
Ceramide (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368705
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330447
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53594
GSE234647_1_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30024
inherited blood coagulation disease	GWASdb SNP-Disease Associations	1.0	2.24642
3-O-Sulfogalactosylceramide (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT3 (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23707
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187051
MCF7_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166216
PI(20:4(5Z,8Z,11Z,14Z)/20:0)	HMDB Metabolites of Enzymes	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882588
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MOLP8	CCLE Cell Line Gene Mutation Profiles	1.0	null
phosphatidylinositol binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986506
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.76307
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52491
Acute Myeloid Leukemia_LAML_TCGA-AB-2965-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13381
integral component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(18:1(9Z)/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3085
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229344_1_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.79237
USF	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.8989
Ganglioside GD3 (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170441
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5152
FUOV1	CCLE Cell Line Gene CNV Profiles	1.0	2.00482
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.243294
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ganglioside GT1b (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.895221
glycan structures biosynthesis 2	KEGG Pathways	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.63649
Glomerular Filtration Rate	DisGeNET Gene-Phenotype Associations	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.09751
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115454
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277145
MFM223	DepMap CRISPR Gene Dependency	1.0	2.15669
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4881
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.0542
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HM-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05817
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31846
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.30267
Ganglioside GM3 (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04018
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143446
PIP3(18:1(11Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.934395
RNF38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01333
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6473-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35945
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD1b (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.86028
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GD3 (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PI(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6406-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP(20:1(11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020405
post-translational protein modification	GO Biological Process Annotations 2015	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22947
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6337
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1a (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
HS766T	CCLE Cell Line Gene Expression Profiles	1.0	1.58557
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.008
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.932182
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2215
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15508
KON	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
Ganglioside GT3 (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22821
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.18497
u266	HPA Cell Line Gene Expression Profiles	-1.0	-0.965273
GTEX-NPJ8-1726-SM-2YUNB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843003
Lung squamous cell carcinoma_LUSC_TCGA-85-A4QQ-01A-41R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3106
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP2(20:3(8Z,11Z,14Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.879
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
HS766T	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
PIP2(18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842246
K562_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169278
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.25
K562_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172943
FOSL2	ENCODE Transcription Factor Targets	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.569347
A549_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188782
HUPT3	DepMap CRISPR Gene Dependency	1.0	2.61441
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
3T3-Swiss albino cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
TRIM28	ENCODE Transcription Factor Targets	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15058
A549_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145357
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17095
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Ganglioside GD2 (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27701
KMH2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0679
Ganglioside GT2 (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Keloid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
Ganglioside GD2 (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:3(6Z,9Z,12Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Celecoxib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188803
Galactosylceramide (d18:1/18:0) 	HMDB Metabolites of Enzymes	1.0	null
CAOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93231
GTEX-WH7G-1026-SM-4LVML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913075
SIX5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176836
hsa-miR-3613-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03256
Ganglioside GD1b (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10533
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.87
glycosylphosphatidylinositol anchor biosynthesis	KEGG Pathways	1.0	null
hsa-miR-4725-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162589
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10408
K562_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279265
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT2 (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199162
GTEX-NPJ7-0011-R2a-SM-2I3GF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07988
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Erythroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.096
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Micropyle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.039
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.825944
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34864
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
C1orf226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39439
THAP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52732
Ganglioside GD2 (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840808
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51459
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Epithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
ER to Golgi transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.127
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836379
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861388
dolichol-phosphate-mannose synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
MCF7_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207662
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.467
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.04111
K562_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212341
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
EB-67-WB79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399677
TMEM234	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04299
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lactosylceramide (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GQ1c (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GD3 (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29693
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2BK20ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ganglioside GD1b (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Protein C Antigen Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Viral cardiomyopathy_Myocardial tissue_GSE4172	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.79487
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06255
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GT1c (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
Buccal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
PIP3(18:1(11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46003
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522761
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90279
H3K4me1_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endopeptidase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Ganglioside GM1 (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266328
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56944
Ganglioside GT2 (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201553
GSE111035,GSE111040_10_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.918917
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214979
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170846
496100537_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22181
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261694
GSE193993_4_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44707
Tetrahexosylceramide (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197147
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.33227
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5679
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303947
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5281
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172045
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(16:1(9Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227416
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014334
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GT1c (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.008503
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46396
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35899
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU761	DepMap CRISPR Gene Dependency	1.0	2.93246
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.00818
Ganglioside GT3 (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(22:5(7Z,10Z,13Z,16Z,19Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03351
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00072
EGR1	ChEA Transcription Factor Targets	1.0	null
Ganglioside GD1b (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151701
hsa-miR-1263	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0933
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
Microgametophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
A549_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191698
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Waist-to-hip ratio adjusted for BMI (age >50)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
SPATA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11689
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.942174
PI(18:1(11Z)/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
ATF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39718
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23035
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38227
SM(d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
WM983B	CCLE Cell Line Gene CNV Profiles	1.0	1.34429
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21514
NCI-H322M	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cer(d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.858704
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ganglioside GT3 (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897215
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41066
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08933
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145759
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
HUPT4	DepMap CRISPR Gene Dependency	1.0	2.98678
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06096
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.84452
PIP2(16:0/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KCL22	CCLE Cell Line Gene Mutation Profiles	1.0	null
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO Biological Process Annotations 2025	1.0	null
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206991
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11904
PI(18:2(9Z,12Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PIP2(16:1(9Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.46806
KYSE140	DepMap CRISPR Gene Dependency	1.0	4.61521
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71814
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE155755,GSE155757_0_v_1_ncoa6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP2(22:4(10Z,13Z,16Z,19Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
PIP2(18:1(9Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
SM(d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Toll-like receptor 1-Toll-like receptor 2 protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.101
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC4006	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05789
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OE-78-XD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20776
Orde	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid follicular epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.293
K562_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176676
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GT3 (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.13588
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEC59	CCLE Cell Line Gene Expression Profiles	-1.0	-2.09233
Ganglioside GM2 (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27666
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.883948
Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169152_5_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	163.626
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60738
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125368
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126092
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45209
u138mg	HPA Cell Line Gene Expression Profiles	1.0	0.938943
Ganglioside GM3 (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66078
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.766658
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MSS51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39669
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0334
PIP(18:2(9Z,12Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-XMD1-0526-SM-4AT4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13205
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
YY1	ChEA Transcription Factor Targets	1.0	null
Ebolavirus(EBOV)_6day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.26679
PIP2(20:4(5Z,8Z,11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2723
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MU-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP(18:1(9Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
K562_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198862
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEF2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GQ1c (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
19861896-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224777
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27028
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trihexosylceramide (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
PIP2(18:2(9Z,12Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3077
GSE123943_1_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24403
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Type 1 diabetes mellitus_Thymic epithelial cell_GSE11	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.08401
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PIP(18:1(11Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ACHE_OE_GDS891_241_mouse_Prefrontal cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
abnormality of coagulation	GWASdb SNP-Phenotype Associations	1.0	1.57154
Ganglioside GD1a (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Melanoma	dbGAP Gene-Trait Associations	1.0	1.23281
Cardiomyoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.507064
Ganglioside GM3 (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
hsa-miR-3128	TargetScan Predicted Conserved microRNA Targets	1.0	0.099701
GTEX-S32W-0926-SM-4AD5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901392
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF521	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16429
Integumentary system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
MCF7_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015471
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
FUOV1	CCLE Cell Line Gene Expression Profiles	1.0	1.4237
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129399
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lactosylceramide (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
BLZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03683
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29715
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Ganglioside GM3 (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154167
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-0726-SM-3MJF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908242
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.040209
PMC6341466__F1	PFOCR Pathway Figure Associations 2024	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145201
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166194
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.966735
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4421	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
messa/dx5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.879
MCF7_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148367
PKM2 pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.894
PI(22:5(4Z,7Z,10Z,13Z,16Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1057
MCF7_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150382
Trihexosylceramide (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
PIP2(18:1(9Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155972
EW-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29984
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZN-0626-SM-3DB7U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835356
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187457
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
phospholipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU387	DepMap CRISPR Gene Dependency	1.0	2.77249
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HS766T	CCLE Cell Line Gene CNV Profiles	1.0	1.81968
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47343
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3834
HMGN3	ENCODE Transcription Factor Targets	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.961234
FOXP2	ENCODE Transcription Factor Targets	1.0	null
PRDM1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SM(d18:0/16:1(9Z)(OH))	HMDB Metabolites of Enzymes	1.0	null
PI(18:2(9Z,12Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07486
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0422744
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDIPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.201
A549_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122597
Ganglioside GT1b (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236054
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72882
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Df	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
Ganglioside GT3 (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
Ganglioside GD1a (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT2 (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
glycolipid metabolic process	GO Biological Process Annotations 2015	1.0	null
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.178815
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD2 (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176132
Ganglioside GM1 (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTEN phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.456
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34097
E2F4_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1a (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293304
PIP2(18:1(11Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
SARS-CoV_96Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.17382
Ganglioside GT2 (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	1.50437
Ganglioside GM1 (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
Post-translational protein modification	Reactome Pathways 2014	1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.1823
Ganglioside GM2 (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
C3A	CCLE Cell Line Gene Expression Profiles	1.0	1.78023
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6003-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0312333
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142630_0_v_2_hiltonol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EJM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.97216
ZNF263	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PI(18:1(9Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148563
KDM5A	ChEA Transcription Factor Targets	1.0	null
K562_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165511
Ganglioside GD1b (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22913
Basophilic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07503
K562_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226534
Ganglioside GT1c (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943606
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01508
PMC4301880__F1	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136609
Zileuton_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245358
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.617
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1925
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0912
Cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.639591
endoplasmic reticulum part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
PMC3591604__F2	PFOCR Pathway Figure Associations 2023	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
PIP(18:2(9Z,12Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Skin Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02693
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
AU565	CCLE Cell Line Gene Expression Profiles	1.0	1.51369
hsa-miR-4477a	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GTEX-VJYA-1726-SM-3NMDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36652
Ganglioside GM2 (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213549
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0029
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11116
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161883
SK-N-AS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RERF-LC-MS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.923002
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.950327
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186656
3-O-Sulfogalactosylceramide (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83573
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PI(20:4(5Z,8Z,11Z,14Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.949641
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectal cancer or advanced adenoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.652288
K562_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155605
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19692
Ganglioside GD2 (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141149
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
EXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85989
PHF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56336
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61049
PI(20:3(8Z,11Z,14Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Medullary thyroid carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3857
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
Synovial sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.272
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33662
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131412
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925769
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZJ-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Rucaparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136719
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02293
SM(d18:0/22:1(13Z)(OH))	HMDB Metabolites of Enzymes	1.0	null
Cancer	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865588
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45889
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.950761
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6954-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-5787-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sphinganine 1-phosphate	HMDB Metabolites of Enzymes	1.0	null
PI(20:3(5Z,8Z,11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.008
KDM5A	ENCODE Transcription Factor Targets	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12874425-mmc1.xlsx-AT_LPS_vs_AT_SLPS-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8335-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
THNSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11792
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1-20517297-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
GTEX-QESD-1726-SM-2S1R7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06786
Cer(d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
PIP2(20:4(8Z,11Z,14Z,17Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48457
NCI-H2444	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT3 (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
Focal Myoclonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0229
PMC10864290-41598_2024_53494_MOESM1_ESM.xlsx-SRG_in_ClinVar-Gene_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GMEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17872
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227679
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37024
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9147_TNNT2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.67384
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD2 (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
Cer(d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Glycosylphosphatidylinositol biosynthesis defect	ClinVar Gene-Phenotype Associations 2025	1.0	null
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.852616
neoplasia of the nasopharynx	GWASdb SNP-Phenotype Associations	1.0	1.75033
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10816
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23045
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40024
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1498
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308082
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_77_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
COPI-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.947
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151252
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31442
A549_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151185
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neuroepithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
GSE163052,GSE163198_4_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(20:4(8Z,11Z,14Z,17Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309541
PI(18:0/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8519
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840356
GSE151612_4_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1842
SM(d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
CACNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45906
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0363625
intrinsic component of endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10872
Grb2-Sos complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.101
Ras signaling pathway	KEGG Pathways 2026	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16125
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
PI(20:3(8Z,11Z,14Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD2 (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.97399
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2956-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.63555
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CDK19_knockdown_148_GSE32108	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.42364
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.62452
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(18:1(9Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
vascular endothelial growth factor signaling pathway	GO Biological Process Annotations 2025	1.0	null
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.383
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	KEGG Pathways 2026	1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845273
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.266608
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90942
positive regulation of endothelial cell migration	GO Biological Process Annotations 2025	1.0	null
PIP3(18:1(9Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225519
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88501
Ganglioside GM1 (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179123
NET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31217
A549_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179205
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67642
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.975678
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.624172
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128004
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTF3C2	ENCODE Transcription Factor Targets	1.0	null
A3-KAW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CREB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2351
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829812
NCI-H1755	COSMIC Cell Line Gene Mutation Profiles	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.195143
J82	CCLE Cell Line Gene CNV Profiles	1.0	1.5924
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NRL_Deficiency_GDS2936_629_mouse_Retinas - 2 days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208104
Intrinsic component of Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.1043
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-4729	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
EP300_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8149
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1b (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12408274-DataSheet3.pdf-10-THAP2_THAP2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06553
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51298
GTEX-Q2AI-0926-SM-48U1F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08207
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Medullary carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HGF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.109
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15918
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NASH_Liver_GSE24807	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.04029
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.604
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243205
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11221
A549_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222364
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ganglioside GM2 (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
PI(20:4(8Z,11Z,14Z,17Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150268
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169301
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.626
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1648	CCLE Cell Line Gene CNV Profiles	1.0	1.81315
Rough endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.547
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9263
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867114
BA/F3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
GA-47-MH68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.730086
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(16:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.067
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234965
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184628
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17134
SK-N-SH	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.888982
PIP3(18:2(9Z,12Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44799
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830693
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927876
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.240826
MCF7_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132721
ACTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54897
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PIP2(16:2(9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	149.733
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97281
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38106
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
Biceps femoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
DPRX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4034
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.7937
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211214
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166061
Lung adenocarcinoma_LUAD_TCGA-62-8394-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13163
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SM(d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)_7Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.00995
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.9403
Ganglioside GM1 (d18:1/26:1(17Z)))	HMDB Metabolites of Enzymes	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.872
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3-Hydroxyflavone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:3(9Z,12Z,15Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Tetrahexosylceramide (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265682
GTEX-UPK5-1126-SM-3GAEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40192
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07774
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305788
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GT1c (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hmc1	HPA Cell Line Gene Expression Profiles	-1.0	-1.28062
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3898
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cer(d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021453
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
K562_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210191
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GT1c (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
PIP3(18:1(9Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Creatinine Measurement, Serum (Procedure)	DisGeNET Gene-Phenotype Associations	1.0	null
Ganglioside GM3 (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55503
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205552
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3233
MCF7_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151525
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SM(d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Ganglioside GT1b (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.83674
Small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08756
Metabolism of proteins	Reactome Pathways 2014	1.0	null
NCIH2347	CCLE Cell Line Gene Expression Profiles	-1.0	-2.66554
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192015
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
spi1_17041602_preleukemic_hscs_lof_mouse_gpl1261_gds2411	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.0739
Ganglioside GD1a (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE142210_11_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GT2 (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WAOSEL	DepMap CRISPR Gene Dependency	1.0	3.49512
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0313953
PI(18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
PMC8759131-advancesADV2021004469-suppl2.xlsx-Table_S1-Supplementary_Table_1_Differentially_expressed_genes_post_knockout_of_MEF2D_in_MOLM-13_AML_cells_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.3782
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208278
SM(d18:0/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6770909__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25212
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58422
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.047388
Cer(d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890251
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GQ1c (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT2 (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
STAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16191
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898695
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40578
Ganglioside GT2 (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nasopharynx carcinoma	GWASdb SNP-Disease Associations	1.0	1.83309
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSK3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34093
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KCNK15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29918
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237182
HCC1187	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38761
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06517
MCF7_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00966268
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRN-1426-SM-3LK5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23861
macrophage	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.48503
GSE242290_1_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEL9217	CCLE Cell Line Gene CNV Profiles	1.0	1.53404
HULC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.624
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6258
PIP2(16:0/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(16:0/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
Lactosylceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362189
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30995
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.6315
FOXA2	ChEA Transcription Factor Targets	1.0	null
MCF7_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133194
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
dolichyl-phosphate-mannose-protein mannosyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.628
Cerebral Atrophy	DisGeNET Gene-Disease Associations	1.0	null
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GPI-anchor transamidase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.04037
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Galactosylsphingosine	HMDB Metabolites of Enzymes	1.0	null
ME1	CCLE Cell Line Gene Expression Profiles	1.0	1.50604
Inositol phosphoceramide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.123
MCF7_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00947834
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.542152
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172778
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53115
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68744
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.008
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55838
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PIP(18:1(11Z)/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286063
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052861
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(18:3(6Z,9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0285593
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1947
PIP2(18:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
glycerophospholipid metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
Sphingosine	HMDB Metabolites of Enzymes	1.0	null
SNUC2A	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11557
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06376
CCNT2	ENCODE Transcription Factor Targets	1.0	null
PIP(16:0/22:2(13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
A549_TMP195_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154322
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184169
A549_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128389
Ganglioside GM1 (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6945
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.22706
Ganglioside GD1a (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.992755
GSE210101,GSE210114_11_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Diastolic blood pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.7
phosphatidylinositol metabolic process	GO Biological Process Annotations 2015	1.0	null
Ganglioside GM3 (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
PI(18:1(11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019988
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1992
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT3 (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900889
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10714
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03022
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03086
PI(18:2(9Z,12Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epi	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
DUXA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21364
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40906
GTEX-XV7Q-1526-SM-4BRWB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2455
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00728
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PI(18:2(9Z,12Z)/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159912
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13242
HS888T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.37239
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2334
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.55106
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GT1b (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GM1 (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.848407
disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.384
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4728-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
MCF7_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162494
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.85789
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.71603
Ganglioside GD3 (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144035
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adenoma	DisGeNET Gene-Disease Associations	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10313
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.4659
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893545
Hair Color	DisGeNET Gene-Phenotype Associations	1.0	null
Bladder Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
SMMC-7721 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.013
Primitive neuroectodermal tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.022
YD-59-WM48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225891
GSE48812_8_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72075
Trihexosylceramide (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
PI(22:5(7Z,10Z,13Z,16Z,19Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6742-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7456
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Attachment of GPI anchor to uPAR	Reactome Pathways 2014	1.0	null
GTF3C2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1b (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Ganglioside GM2 (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(18:0/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(20:3(5Z,8Z,11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
PIP2(16:0/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93W-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33415
membrane lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
amygdaloid complex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11893
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38498
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164044
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41818
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872815
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
PIP2(16:0/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30745
Ganglioside GT3 (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
ORAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01051
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826372
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177104
GC-72-GY67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209788
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Microneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.16
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06623
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.903581
PIP2(18:3(9Z,12Z,15Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
PIP(16:0/22:5(4Z,7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAMALWA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.742785
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IgM B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.616
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937552
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT3 (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
POM121C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57244
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04914
K562_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292984
all	GWASdb SNP-Phenotype Associations	1.0	0.129873
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32977
Nasopharyngeal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.48
8305C	CCLE Cell Line Gene CNV Profiles	1.0	2.79655
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155276
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD38	CCLE Cell Line Gene CNV Profiles	1.0	2.71867
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18439
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920577
PIP2(20:4(5Z,8Z,11Z,14Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.55939
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.99135
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PIP(18:1(9Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1424
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147998
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ganglioside GD2 (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57404
FB-56-SR65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222013
Leaf sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
PIP2(20:1(11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58241
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.95603
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33154
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97665
Ganglioside GT2 (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.897898
NELFE	ENCODE Transcription Factor Targets	1.0	null
jm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
melanoma	GAD Gene-Disease Associations	1.0	null
Tetrahexosylceramide (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP2(16:1(9Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180468_2_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PI(18:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
SW403	CCLE Cell Line Gene Expression Profiles	1.0	1.38883
EFM192A	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74731
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15846
IL6ST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73651
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10316
Arrhythmogenic Right Ventricular Cardiomyopathy_Myocardial tissue_GSE4120	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.62344
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7211
K562_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167688
Gastric cancer	KEGG Pathways 2026	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28756
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00853396
carbohydrate derivative metabolic process	GO Biological Process Annotations 2015	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.99323
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.64877
anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24268
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ganglioside GD3 (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865305
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142153
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1b (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
LSM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01338
HOXB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4231
Suntan	DisGeNET Gene-Phenotype Associations	1.0	null
PARP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03587
HCE4	DepMap CRISPR Gene Dependency	1.0	3.7663
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.54646
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1a (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
496100401_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20443
PMC4431731-pgen.1005211.s002.xlsx-ERG_TRISOMY-Unnamed_2_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.4823
Colorectaladenocarcinoma	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.915771
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70414
PMC8120202__F4	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052504
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09991
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951374
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.949203
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96208
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PI(16:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.12218
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XV7Q-2126-SM-4BRVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03671
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156075
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835012
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41212
K562_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217112
GPAA1	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.79231
PI(20:1(11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.911478
GSE152441,GSE152442_1_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4301880__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977405
PI(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0161
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SM(d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.890968
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.870161
MERO14	DepMap CRISPR Gene Dependency	1.0	2.06052
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50892
MCF7_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132725
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GT1c (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1a (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TM31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71381
Ganglioside GM2 (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD3 (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13919
Phospholipase D signaling pathway	KEGG Pathways 2026	1.0	null
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT55	DepMap CRISPR Gene Dependency	1.0	2.49838
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151709
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0783
PIP(18:3(6Z,9Z,12Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(18:3(9Z,12Z,15Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
BRCA1-Rad51 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.546
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0704
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1c (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.41095
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Galabiosylceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
Mantle cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
SM(d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
SM(d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016055
SP4	ENCODE Transcription Factor Targets	1.0	null
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.846642
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.916403
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63129
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902482
Ganglioside GT1b (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185818
E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.604879
OVSAHO	CCLE Cell Line Gene Expression Profiles	1.0	2.41013
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.616494
BCL3	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.966743
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10572
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11937
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999908
PMC11951866-mmc1.pdf-3-FOXK1_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1143	DepMap CRISPR Gene Dependency	1.0	3.10374
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48731
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7937
Tetrahexosylceramide (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.33667
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11116
GSE240468_3_v_6_nfyc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KM12	DepMap CRISPR Gene Dependency	1.0	2.46851
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247309
Sclerenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280454
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ganglioside GT1b (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.928913
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.75241
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212023
Ganglioside GM1 (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21539
GSE232944_1_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.73022
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP(18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
A549_Divalproex Sodium_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134001
HDAC1	ENCODE Transcription Factor Targets	1.0	null
PIP2(16:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03424
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173455
PIP(16:0/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GD2 (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.977392
Ganglioside GT1b (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1b (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5815
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5257
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE195568_6_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.75855
Macrogamete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45514
MCF7_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226125
organophosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.43709
JVM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.9447
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842979
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.34
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H1648	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
colon_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.29291
hsa-miR-4472	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
NFIC	ENCODE Transcription Factor Targets	1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.67238
molecular_function	GO Molecular Function Annotations 2015	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.23068
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29747
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14674
PI(16:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
A549_Belinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132649
Tetrahexosylceramide (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1b (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0381249
EGR1	ENCODE Transcription Factor Targets	1.0	null
PIP2(20:3(5Z,8Z,11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP(22:4(10Z,13Z,16Z,19Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
NCIH647	CCLE Cell Line Gene CNV Profiles	1.0	1.46886
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
N-Glycoloylganglioside GM2	HMDB Metabolites of Enzymes	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080902
Ganglioside GD2 (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.7338
PIP2(18:1(9Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP2(18:2(9Z,12Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PMC3874794__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Pork consumption	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.81549
UKE-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05287
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
SM(d18:0/24:1(15Z)(OH))	HMDB Metabolites of Enzymes	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29962
MCF7_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147436
Ganglioside GQ1c (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143426
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-KLF4_correlates_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03445
ZNF677	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41344
Developmental and epileptic encephalopathy 55	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
SRF	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GD3 (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Glucosylceramide (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02776
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.01119
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PIP2(18:1(11Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01141
Lung squamous cell carcinoma_LUSC_TCGA-39-5036-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14983
MCF7_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142708
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_ZFP42_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05281
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07391
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839497
membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
WHSC1	ENCODE Transcription Factor Targets	1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GQ1c (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dinoprost	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1-23403033-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.960195
Phosphatidylinositol 3-kinase complex, class IA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.271
CE-04-PX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225851
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_21-Supplementary_Table_21_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_TCGA_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE241031_0_v_7_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
parahippocampal gyrus, right, bank of the cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.99768
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55312
GSE183101_0_v_1_hvcn1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Galabiosylceramide (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
AE-32-DP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254667
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.01093
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormality of the integument	GWASdb SNP-Phenotype Associations	1.0	0.155925
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.3104
FF-46-OR35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233552
SRF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02595
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP(18:1(11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868418
PIP2(18:3(6Z,9Z,12Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Integral component of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.007
MCF7_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214452
MCF7_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140404
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.42695
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03476
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02341
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13919
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55884
BCPAP	CCLE Cell Line Gene CNV Profiles	1.0	1.39968
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56658
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20304
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023558
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-2226-SM-3GILQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894005
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.956222
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.67724
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.952249
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2342
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Renal cell carcinoma	KEGG Pathways 2026	1.0	null
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901877
GSE151612_0_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010777
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.067615
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06598
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.151388
GSE239898,GSE239899_1_v_0_hiltonol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GD2 (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0458374
Intrinsic component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14489
BTK_knockout_2_GDS1346	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.100054
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220428
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919977
Ganglioside GT1c (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1b (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT1c (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
cancer	GAD High Level Gene-Disease Associations	1.0	0.293278
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17615
TMBIM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19775
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56733
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07865
Mannosyl-inositol-phosphorylceramide	HMDB Metabolites of Enzymes	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
PIP2(22:4(7Z,10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
hsa-miR-3652	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.115538
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE70499_3_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intrinsic component of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.006
K562_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157347
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ganglioside GM3 (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
STK155799	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
PIP(20:3(8Z,11Z,14Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
A549_Selisistat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156945
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142283
RELA	ENCODE Transcription Factor Targets	1.0	null
PMC5452392-13058_2017_854_MOESM3_ESM.xlsx-Table_S7-Variants_within_GWAS_blocks_control_MAF_0_01_case_MAF_control_MAF_within_gwas_breast_cancer_regions_deleteious_score_0_5_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PI(18:3(9Z,12Z,15Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
HT55	CCLE Cell Line Gene CNV Profiles	1.0	1.88801
SIX5_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT3 (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Final leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
PIP(18:1(9Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
hela	HPA Cell Line Gene Expression Profiles	-1.0	-1.14166
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PML	ENCODE Transcription Factor Targets	1.0	null
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03566
Thyroid follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
SLR20	CCLE Cell Line Gene Expression Profiles	1.0	1.35122
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10414
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0451421
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.7653
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5565
PIP(22:2(13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KZ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6959-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2631
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PI(22:3(10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211128_7_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842979
Necrosis	CTD Gene-Disease Associations	1.0	1.36047
Ganglioside GM3 (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.786513
A549_BMS-911543_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156721
RFX5	ENCODE Transcription Factor Targets	1.0	null
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230845
PI(18:1(11Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
PBX3	ENCODE Transcription Factor Targets	1.0	null
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.598927
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27091
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147963
A549_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133106
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6220-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42508
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of blood vessel endothelial cell migration	GO Biological Process Annotations 2025	1.0	null
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118302
YUHOIN0650	DepMap CRISPR Gene Dependency	1.0	2.40884
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865853
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21179
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HUH6	DepMap CRISPR Gene Dependency	1.0	3.16337
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882577
MGH-U4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PI(18:0/22:4(10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
SM(d18:0/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
A549_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148768
Ganglioside GM3 (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59948
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05081
PIP(18:2(9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
MKN74	CCLE Cell Line Gene CNV Profiles	1.0	1.55245
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52231
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sphingosine 1-phosphate	HMDB Metabolites of Enzymes	1.0	null
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15306
gpi-anchor transamidase complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6826
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74597
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00112
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.28116
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-495	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835752
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831972
Ganglioside GM2 (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
MAN2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21454
Ganglioside GM2 (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.914574
hsa-miR-939	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7952
GTEX-WZTO-1026-SM-3NM9P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08927
MCF7_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156029
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45889
Ganglioside GM1 (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2742-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Galabiosylceramide (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.96176
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intrinsic component of organelle membrane	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8402-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196503
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GT2 (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
SOX17_OE_GDS3300_124_human_HESC (CA1 and CA2)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00951592
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182885
Ganglioside GQ1c (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45482
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219327
FD-20-OG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216312
METTL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62529
Cer(d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256037
Thyroid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.12
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.82404
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.977487
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.94727
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PCI4B	DepMap CRISPR Gene Dependency	1.0	2.79019
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
Thyroid epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.143
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE218060_1_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SREBF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73194
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GM3 (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.442708
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20138
Ganglioside GT1c (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40324
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
venetoclax_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146708
PIP2(20:3(8Z,11Z,14Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
A549_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016576
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439623
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.36675
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.909267
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405611
A549_G007-LK_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173533
GSE70935_2_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organophosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
NEUROD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42524
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PZ-01A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.56611
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Galabiosylceramide (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
4008_ICA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513685
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015527
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4818
HS255T	CCLE Cell Line Gene Expression Profiles	-1.0	-3.02579
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.27511
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYC-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222018
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-71-6725-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1245b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.07115
RHNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62856
PCBP2_02_123	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58684
Attachment of GPI anchor to uPAR	Reactome Pathways 2024	1.0	null
Ganglioside GD1a (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.008
RBBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18072
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193685_2_v_3_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW-1736 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.084
RSV_24Hour_19459069_GSE3397	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.28309
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16075
insulin receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149966
PI(18:1(11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2967-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell-cell junction	GO Cellular Component Annotations 2025	1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2189
Bipolar disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
Hip circumference adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.909691
PI(18:0/22:5(4Z,7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
Galactosylceramide (d18:1/20:0) 	HMDB Metabolites of Enzymes	1.0	null
PIP2(20:4(8Z,11Z,14Z,17Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
SM(d18:0/14:1(9Z)(OH))	HMDB Metabolites of Enzymes	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91063
PI(18:3(6Z,9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PI(20:2(11Z,14Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGFR-Shc-Grb2-Sos complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.152
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.31987
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectal Cancer	DisGeNET Gene-Disease Associations	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRIMPOL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07527
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD2 (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GM2 (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
GSE108500_1_v_0_foxp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213055
WC-67-DI84_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205953
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.24007
GSE151090_2_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uroepithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
hsa-miR-3173-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8337
MCF7_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130723
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.47896
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	135.108
A3KAW	CCLE Cell Line Gene Mutation Profiles	1.0	null
HCC1569	CCLE Cell Line Gene Expression Profiles	1.0	1.78292
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5482
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ganglioside GM1 (18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.42485
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0346482
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918733
A549_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014558
REST	ENCODE Transcription Factor Targets	1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836253
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-1026-SM-48TZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866007
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2826
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.961247
PI(18:3(9Z,12Z,15Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951043
Tetrahexosylceramide (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51412
ZR7530	CCLE Cell Line Gene Mutation Profiles	1.0	null
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
Ganglioside GD1a (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Toremifene Citrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128326
Ganglioside GT1c (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
A549_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019095
PIP2(18:2(9Z,12Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0803
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4923
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
PIP2(16:0/22:5(7Z,10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
PI(16:2(9Z,12Z)/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0354496
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168435
FLI1	ChEA Transcription Factor Targets	1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16276
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
immune system disease	GWASdb SNP-Disease Associations	1.0	0.444182
Ganglioside GM1 (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227522
PIP3(16:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7216
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18559
PIP2(20:4(8Z,11Z,14Z,17Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.86057
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0277342
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.873324
Axolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.859
DMWD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33748
HCC1937	DepMap CRISPR Gene Dependency	1.0	2.41492
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SM(d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
T84	DepMap CRISPR Gene Dependency	1.0	2.97881
Dihydroceramide	HMDB Metabolites of Enzymes	1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.9714
Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
occipito-temporal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.952115
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(20:1(11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7575
attachment of gpi anchor to protein	GO Biological Process Annotations 2015	1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7471
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.386
Ganglioside GD3 (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
K562_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0406937
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5936-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211128_3_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.706792
Acute Myeloid Leukemia_LAML_TCGA-AB-2842-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Galabiosylceramide (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91975
WDFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04781
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02941
Cer(d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193917
binding	GO Molecular Function Annotations 2015	1.0	null
PI(16:0/22:5(4Z,7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14836
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-let-7b-5p	MiRTarBase microRNA Targets	1.0	null
MKN7	CCLE Cell Line Gene Expression Profiles	1.0	1.45915
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04355
K562_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344184
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18618
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858894
MCF7_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112121
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08309
HMEpC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.988
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52063
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016842
TK10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11682
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.83053
LGMN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15177
SM(d16:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT3 (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
THAP11	ChEA Transcription Factor Targets	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
non-Hodgkin lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(18:1(11Z)/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09474
Ganglioside GD2 (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231236
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09758
PIP(20:4(5Z,8Z,11Z,14Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63242
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PI(22:2(13Z,16Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9254
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212571
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3695
GTEX-POMQ-1426-SM-3P61D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03229
Ganglioside GQ1c (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
PI(22:4(7Z,10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SEC24C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09751
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7312
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9259
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016743
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(16:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.12323
Tetrahexosylceramide (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
Basolateral plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.036
K562_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230808
MYC_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE245270_2_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33842
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-2726-SM-4BOQ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07222
SLC2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04477
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146306
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Microspore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.25
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
SM(d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
Cer(t18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7881
inner SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02601
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506433
9396_TTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.951613
Sarcoma_SARC_TCGA-IW-A3M5-01A-22R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0641
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21585
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
PIP(18:1(9Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PI(18:1(11Z)/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27734
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35784
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.90266
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1b (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.867113
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.691228
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gpi	GeneRIF Biological Term Annotations	1.0	null
Brown vs. black hair color	GWAS Catalog SNP-Phenotype Associations 2025	1.0	6.5
PIP2(16:0/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286966
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36447
PI(20:4(8Z,11Z,14Z,17Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
ZNF432	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53659
SM(d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
SUPM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77908
Ganglioside GT3 (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188749
regulation of receptor signaling pathway via STAT	GO Biological Process Annotations 2025	1.0	null
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.0774
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.9218
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.878189
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43915
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48662
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78745
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lactosylceramide (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02956
GSE87412,GSE92423_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02038
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GM1 (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
K562_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196959
SLC19A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26362
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.880608
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161855
MCF7_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247053
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.4022
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.99986
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194662
RAD21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47112
Ganglioside GT3 (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
PI(16:0/22:5(7Z,10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
cancers	GeneRIF Biological Term Annotations	1.0	null
PI(16:1(9Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
PIP(18:3(9Z,12Z,15Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012882
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
glycerolipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PIP(18:0/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
RPMI-7951	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834575
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1b (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
PIP2(20:4(8Z,11Z,14Z,17Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PI(20:4(5Z,8Z,11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.281686
Ganglioside GD1a (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
gpi anchor biosynthetic process	GO Biological Process Annotations 2015	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:0/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236926
layer II of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.927555
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969509
N-Stearoylsphingosine	HMDB Metabolites of Enzymes	1.0	null
Hyperphosphatasia with impaired intellectual development syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252563
PI(22:3(10Z,13Z,16Z)/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143199
J82	CCLE Cell Line Gene Expression Profiles	1.0	1.51413
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34068
melanoma	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
UT-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.585
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:2(9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GM3 (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45229
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT3 (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
JIMT-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
K562_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143132
MCF7_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142111
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.243
phospholipid metabolic process	GO Biological Process Annotations 2015	1.0	null
K562_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223901
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95115
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.26859
K562_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0335596
Developmental and epileptic encephalopathy 80	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.76
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.888474
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31371
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.566468
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMS20	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160066
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6244
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217194
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05938
Ganglioside GD3 (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290552
GINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42961
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.4518
Ganglioside GT1b (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD1b (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.885536
Fer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30261
MCF7_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161714
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.889124
Ganglioside GM1 (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PI(18:0/22:4(7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD3 (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD1a (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
PIP2(18:1(11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
SK-N-MC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
BICR78	DepMap CRISPR Gene Dependency	1.0	3.81365
SF767	DepMap CRISPR Gene Dependency	1.0	2.70056
ZR-75-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PIP3(18:1(11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46821
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016055
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22387
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(18:2(9Z,12Z)/22:2(13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COASY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79729
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68751
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-W5WG-2326-SM-3GIJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00455
PI(18:1(9Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-XOTO-0326-SM-4B66K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960611
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05019
PIP2(16:2(9Z,12Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glycolipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
integumentary system disease	GWASdb SNP-Disease Associations	1.0	0.238505
Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7001271__F1	PFOCR Pathway Figure Associations 2023	1.0	null
ZNF555	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13834
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PB-40-YB26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248097
generalized abnormality of skin	GWASdb SNP-Phenotype Associations	1.0	0.226537
anion binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ceramide (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
FXYD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91731
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927634
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13687
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208426
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0380916
SM(d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0370284
CES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14716
RERFLCAI	CCLE Cell Line Gene CNV Profiles	-1.0	-2.445
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992407
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0326-SM-2TF5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06876
PIP2(16:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01726
PIP2(18:2(9Z,12Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.940395
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.626723
Lung adenocarcinoma_LUAD_TCGA-05-5425-01A-02R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169152_5_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT2 (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
E2F1	ChEA Transcription Factor Targets	1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.1951
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021981
SERPINB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19324
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TE125T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74836
GSE202744_1_v_0_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Melanoma	GWAS Catalog SNP-Phenotype Associations	1.0	0.863028
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EVSAT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61551
PIP2(18:0/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
SKN3	DepMap CRISPR Gene Dependency	1.0	2.60833
supramarginal gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53272
GTEX-R53T-1326-SM-48FCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00401
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD3 (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213121
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139861
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(16:0/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39129
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7757
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PIP(20:4(8Z,11Z,14Z,17Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155004
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.965186
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.770694
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873993
ICC9	DepMap CRISPR Gene Dependency	1.0	5.31886
AB-43-XJ34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446417
CRCGN012_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06918
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881721
PI(16:2(9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22168
GSE128634,GSE128636_4_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ganglioside GD1a (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.862793
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.530172
Ganglioside GD3 (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Trihexosylceramide (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
VPS52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60972
PAX5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842979
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.077906
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371226
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QA-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.75
Ceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	107.273
GPI anchored protein biosynthesis	GO Biological Process Annotations 2025	1.0	null
Thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982165
paclitaxel_homo sapiens_gpl570_gse39042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of the nose	GWASdb SNP-Phenotype Associations	1.0	0.844241
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.992744
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172249
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.927885
POLR2A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Integumentary system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.24007
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDAMB231	DepMap CRISPR Gene Dependency	1.0	2.36049
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP(18:3(6Z,9Z,12Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q9-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PI(18:1(11Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SM(d17:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:1(9Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GQ1c (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIGT	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10947
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2291	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83332
PI(16:1(9Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212389
TC71	DepMap CRISPR Gene Dependency	1.0	2.55972
Lactosyceramide (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71433
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.0
glycolipid binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20105
Serum Total Cholesterol Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PIP(22:4(7Z,10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57781
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
biological regulation	GO Biological Process Annotations 2015	1.0	null
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25878
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374208
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GM3 (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
NHDF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33203
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70654
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GQ1c (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-SIU8-0326-SM-2XCDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4515
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30865
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(18:1(9Z)/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1811
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.00597
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.984815
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carcinoma, Papillary	DisGeNET Gene-Disease Associations	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
PLAUR	Pathway Commons Protein-Protein Interactions	1.0	null
ACTR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2278
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.899923
SRF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132759_4_v_2_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GT1c (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.626
Ganglioside GT1b (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.909529
MCF7_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151299
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357671
High Density Lipoprotein Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03159
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46168
Ganglioside GD2 (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243724
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.939187
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.185824
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.698993
Ganglioside GM2 (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
GNG13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04143
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.703431
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119147
PIP(20:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930924
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.221793
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111582
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38238
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174028
K562_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229125
Ganglioside GT1b (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1082-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132773
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922894
RCOR1	ChEA Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.95205
ion binding	GO Molecular Function Annotations 2015	1.0	null
lipid binding	GO Molecular Function Annotations 2015	1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.138
Cer(d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.97875
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9016
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.917874
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126392
MCF7_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011737
PIP(16:2(9Z,12Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24525
Ganglioside GQ1c (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1679
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Ganglioside GQ1c (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-SNMC-1626-SM-4DM52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986397
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gpi anchor metabolic process	GO Biological Process Annotations 2015	1.0	null
Ganglioside GT1c (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.827615
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16284
PIP2(18:0/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZE-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integrin alpha6-beta4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.996835
A549_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140363
inner SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20564
membrane	GO Cellular Component Annotations 2015	1.0	null
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141371
KS1	CCLE Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1649
Ganglioside GD1b (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61213
PIP2(18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.95273
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.0435
UQCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15327
SM(d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301863
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.921201
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122814
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191266
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.637594
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oncogene	GeneRIF Biological Term Annotations	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138299
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9779
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842979
5550_NDUFAF7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.601995
PI(18:3(6Z,9Z,12Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.80597
Ganglioside GM3 (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT3 (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.3077
CTCF	ENCODE Transcription Factor Targets	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.642382
M/G1 phase-specific MADS box-forkhead transcription factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.636
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsf1_00000000_tcell_lof_mouse_gpl1261_gse41005	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.212439
MCF7_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183027
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29666
GSE80537_0_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD3 (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(20:1(11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1057
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.41326
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38824
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141861
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:2(9Z,12Z)/20:0)	HMDB Metabolites of Enzymes	1.0	null
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
phosphatidylinositol binding	GO Molecular Function Annotations 2025	1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05216
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of angiogenesis	GO Biological Process Annotations 2025	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22851
Ganglioside GQ1c (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
HCT15	CCLE Cell Line Gene Mutation Profiles	1.0	null
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7844
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
icSARS CoV_30Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.82533
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152065
PIGU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48871
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GM3 (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
SAR020106	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.56
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.638212
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47957
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01001
Gastroesophageal junction	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.776
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1659
Anchoring junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6285
K562_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271509
Integral component of endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PIP2(18:0/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4061
MCF7_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215362
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP(16:1(9Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6514
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03158
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85117
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20732
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17052
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-09-MD49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337148
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4551
SRY	ChEA Transcription Factor Targets	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202038
SIX5	ENCODE Transcription Factor Targets	1.0	null
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.78825
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
c-terminal protein amino acid modification	GO Biological Process Annotations 2015	1.0	null
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020442
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.17307
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.71507
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878112
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane region	GO Cellular Component Annotations 2015	1.0	null
paracentral lobule, anterior part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11584
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
Ceramide (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155144
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0318818
PI(18:1(9Z)/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85737
K562_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0419922
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86459
MCF7_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160431
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0384497
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(18:1(9Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148182
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11538
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16427
MYC_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123943_4_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00733
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8671
Ganglioside GD3 (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.0182
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3142	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43952
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153641
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74811
TAF1	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GD3 (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08692
CEBPD	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GM1 (18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32675
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.06571
A549_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136911
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RWS6-1326-SM-47JXB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00223
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.426872
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
glycolipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K27ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
subiculum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.863462
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Secondary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314309
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.848
Ganglioside GD2 (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05827
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13407
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193967
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.88815
PIP2(22:2(13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.916038
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cer(d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
PMC7001271__F1	PFOCR Pathway Figure Associations 2024	1.0	null
protein maturation	GO Biological Process Annotations 2025	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-2226-SM-2S1PM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859739
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP2(20:3(5Z,8Z,11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GSE144453,GSE144454_1_v_0_tfdp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160733
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.877819
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03845
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960219
PIP2(18:1(11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879867
PI(18:3(6Z,9Z,12Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.887032
Sphinganine	HMDB Metabolites of Enzymes	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_G007-LK_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142983
EJM	CCLE Cell Line Gene Mutation Profiles	1.0	null
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021507
ChIP_MYC_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21968
NCIH1373	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40541
K562_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164647
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_11_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TEAD4	ChEA Transcription Factor Targets	1.0	null
Lactosylceramide (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23108
el2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
pharynx cancer	GWASdb SNP-Disease Associations	1.0	1.37057
K562_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295536
catalytic complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.001953
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963102
K562_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247201
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25282
Triglycerides Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
PI(20:3(8Z,11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.32205
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57159
Ganglioside GT1b (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1c (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
ABC1	DepMap CRISPR Gene Dependency	1.0	2.26995
PIP2(18:1(9Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Intrinsic component of endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PI(20:4(8Z,11Z,14Z,17Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Systolic blood pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
Nutritional deficiency, NEC_Skeletal Myocyte_GSE1776	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.8445
SM(d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Gingival epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16465
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.93277
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXO1_KD_GDS2720_477_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MCF7_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255242
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0324794
A549_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014133
A549_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143407
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221146
Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68872
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29409
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
MCF7_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170413
A549_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125648
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0169
STAT1	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19946
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0354695
YD38	CCLE Cell Line Gene Expression Profiles	1.0	3.40796
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57159
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bisphenol A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01141
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178891
MEF2A	ENCODE Transcription Factor Targets	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09432
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(18:3(6Z,9Z,12Z)/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01372
Lung squamous cell carcinoma_LUSC_TCGA-39-5021-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP(18:0/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCC-25 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23386
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.6648
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GLIPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27076
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002908
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.74174
GTEX-NPJ7-1726-SM-2YUNA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24581
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05437
Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(18:0/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myoclonic Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GT2 (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.99323
MCF7_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0301185
urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.97296
NCIH508	CCLE Cell Line Gene CNV Profiles	-1.0	-3.17136
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
GTEX-P4PP-2026-SM-3P61N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968634
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38266
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3465
Caspase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.204
Lung adenocarcinoma_LUAD_TCGA-86-8279-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carcinoma Of Bladder	DisGeNET Gene-Disease Associations	1.0	null
MRPL46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51256
integral component of endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
ErbB signaling pathway	KEGG Pathways 2026	1.0	null
GAA1-GPI8-PIGT-PIG-PIGS complex	CORUM Protein Complexes	1.0	null
Ganglioside GD2 (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
EPS15L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34517
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77964
PIP3(16:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.36
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36602
SM(d18:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Body Weight	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86932
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular response to vascular endothelial growth factor stimulus	GO Biological Process Annotations 2025	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3307
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15702
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-1326-SM-4DXU7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965585
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1b (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249234
YEATS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43279
Malignant Melanoma	DisGeNET Gene-Disease Associations	1.0	null
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134397
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.982715
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01812
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22202
Ppes	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
YY1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-767-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
sc93	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00446
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0197
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.768475
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2789
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09457
PIP2(18:0/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07402
CAL851	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5699
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5637	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endothelial cell migration	GO Biological Process Annotations 2025	1.0	null
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146405
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146952
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.89257
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2376
MXI1	ENCODE Transcription Factor Targets	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38987
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(20:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204471
GSE94849_7_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SM(d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194352
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052577
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Phosphatidylinositol phosphate phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.458
epidermal growth factor receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PI(22:3(10Z,13Z,16Z)/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
cancer	GWASdb SNP-Disease Associations	1.0	0.182478
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00995
cell surface receptor protein tyrosine kinase signaling pathway	GO Biological Process Annotations 2025	1.0	null
A549_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208971
Sporulated oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.137
Ganglioside GM2 (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.916741
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7688
5637	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1a (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054964
Ganglioside GQ1c (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
Oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.275
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP(18:0/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
CDK4_knockdown_225_GSE8866	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.61267
Melanoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.008
Skin disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
hsa-miR-1178	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168949
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51922
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Glucosylceramide (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18921
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04488
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
WM1552C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Asthma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.71549
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149774
Multiple congenital anomalies-hypotonia-seizures syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
GTEX-SUCS-1726-SM-32PM8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59902
FOS	ENCODE Transcription Factor Targets	1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GD1a (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-X5EB-1026-SM-46MVU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869229
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3667-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CREB1	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01359
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.706753
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270637
Acute Myeloid Leukemia_LAML_TCGA-AB-2969-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.882496
Ganglioside GT2 (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
cellular response to insulin stimulus	GO Biological Process Annotations 2025	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.841854
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6326
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825445
Ganglioside GT1c (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT2 (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
Galactosylceramide (d18:1/18:1(9Z)) 	HMDB Metabolites of Enzymes	1.0	null
JHH1	DepMap CRISPR Gene Dependency	1.0	5.4457
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8310-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PI(18:2(9Z,12Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35644
HT115	CCLE Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ganglioside GM2 (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PI(18:1(11Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130148
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.93277
NCIH854	CCLE Cell Line Gene Expression Profiles	1.0	1.45274
PIP(18:2(9Z,12Z)/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-VUSG-2726-SM-4KKZJ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.39468
PIP(20:1(11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
CGS 35066	DeepCoverMOA Drug Mechanisms of Action	1.0	0.19
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20348
Galactosylceramide (d18:1/24:1(15Z)) 	HMDB Metabolites of Enzymes	1.0	null
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280771
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4318
A549_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178411
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240544
Ganglioside GM1 (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
N-Palmitoylsphingosine	HMDB Metabolites of Enzymes	1.0	null
K562_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225112
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242308
KAT2B	ENCODE Transcription Factor Targets	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488326
Ganglioside GM1 (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.128237
MYC_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE116492,GSE116495_3_v_1_stag2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ganglioside GD3 (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249133
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247176
K562_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265264
Ganglioside GT1b (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880967
Ganglioside GM2 (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UMRC7	DepMap CRISPR Gene Dependency	1.0	3.50073
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SM(d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JVM2	CCLE Cell Line Gene Mutation Profiles	1.0	null
Chronic lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.25
Buccal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.503
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S0-EE-XGII_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223765
PIP(18:1(11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274389
Ganglioside GT1b (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
GTEX-T2YK-0326-SM-4DM7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877888
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140581
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(18:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PI(16:0/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26698
Bundle sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.765
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32897
Ganglioside GT3 (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245999
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143489
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26511
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27688
Ganglioside GT1c (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
blood coagulation disease	GWASdb SNP-Disease Associations	1.0	1.61367
PI(18:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT2 (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149393
TCF3	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GD1a (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04608
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cer(d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27903
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02445
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP(18:1(11Z)/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196514
Epstein-Barr Virus Infections	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16901
inner CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.903714
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4078
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Galactosylceramide (d18:1/26:1(17Z)) 	HMDB Metabolites of Enzymes	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF875	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33718
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(22:5(7Z,10Z,13Z,16Z,19Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.897803
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.94317
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1509
HCC1187	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75667
FU97	CCLE Cell Line Gene Expression Profiles	1.0	1.77079
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05838
PI(16:0/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25835
Low Density Lipoprotein Cholesterol Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31972
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018724
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195685
Lung adenocarcinoma_LUAD_TCGA-55-8096-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEPG2	CCLE Cell Line Gene Expression Profiles	1.0	1.63032
Ganglioside GM2 (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017731
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
glycerolipid metabolic process	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ganglioside GD1b (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29387
MCF7_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155184
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.839034
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gfi1b_OE_GDS4302_425_mouse_AMuLV (pro-B Abelson leukemia virus transformed) cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glucosylceramide (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.79438
ETS1	ENCODE Transcription Factor Targets	1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222823
PIP2(22:3(10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08118
ChIP_THAP11_20581084	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018554
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
C4II	DepMap CRISPR Gene Dependency	1.0	3.6341
A549_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151849
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73487
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.69135
MCF7_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201725
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.709594
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.272132
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.9394
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51722
K562_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262139
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841709
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08238
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE171572_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A49D-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-1426-SM-2S1QU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03002
Trihexosylceramide (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91667
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017345
Phosphatidylinositol-3,4,5-trisphosphate	HMDB Metabolites of Enzymes	1.0	null
JB-75-NC66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259929
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.75499
8305C	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844622
Nasal epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
Demeclocycline_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.014952
PIP(20:3(5Z,8Z,11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PI(20:4(8Z,11Z,14Z,17Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
ILVBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41763
GSE148252_7_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.89157
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5394
Ganglioside GM3 (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
JK1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74846
K562_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181822
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the skin	GWASdb SNP-Phenotype Associations	1.0	0.185158
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GT3 (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_10_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20916
skin cancer	GWASdb SNP-Disease Associations	1.0	0.622745
Ganglioside GQ1c (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CBC632 (AKAP13)	NURSA Protein Complexes	1.0	null
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GPI transamidase subunit PIG-U	InterPro Predicted Protein Domain Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867526
MCF7_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129923
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GM3 (d18:1/26:1(17Z)))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GQ1c (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD1a (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234301
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931079
GTEx Heart 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-3.00914
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ganglioside GM3 (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.848214
LC-1-SQ	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
MNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10374
K562_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173155
PIP(16:0/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	1.93883
PIP2(18:1(9Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251767
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247017
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.332
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23103
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12257
PIP2(22:5(4Z,7Z,10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68854
Ganglioside GM3 (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1a (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R3-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.8347
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SM(d18:0/22:2(13Z,16Z)(OH))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GQ1c (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478069
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8605
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158419
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200066
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT3_01_334	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60666
Ganglioside GQ1c (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
PIP(18:1(11Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31336
regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
Transitional cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0984
A549_UNC1999_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113749
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256462
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PI(18:1(9Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(18:1(11Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Weight	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
FOXF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44746
gpi anchor binding	GO Molecular Function Annotations 2015	1.0	null
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
K562_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189832
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07562
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87223
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23191
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRDM1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53488
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6345
SM(d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
PI(16:0/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188089
GTEX-S32W-1426-SM-4AD66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91514
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4298
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92758
MCF7_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207881
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883787
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Melanoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.5
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30088
gastrointestinal system cancer	GWASdb SNP-Disease Associations	1.0	0.332631
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP2(18:1(9Z)/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
PI(18:1(9Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
Microtubules	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.825497
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198369
Ganglioside GT3 (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pyrene	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
HLE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEL290	DepMap CRISPR Gene Dependency	1.0	3.47715
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GM1 (18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.984912
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6788
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93316
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143288
NCIH1373	CCLE Cell Line Gene Expression Profiles	-1.0	-2.06557
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0721
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.053671
phosphatidylinositol biosynthetic process	GO Biological Process Annotations 2025	1.0	null
ETS1	ChEA Transcription Factor Targets	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56006
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PI(18:1(11Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1b (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236785
K562_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138791
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288526
Smoking status (ever vs never smokers)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.829637
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14673
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE158632_2_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP2(18:3(6Z,9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperphosphatasia with impaired intellectual development syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149168
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343761
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352291
ZBTB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22936
PIP2(16:1(9Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0386771
GTEX-T2IS-1126-SM-4DM6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09254
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH889	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77724
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198248
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.2534
Post-translational modification: synthesis of GPI-anchored proteins	Reactome Pathways 2014	1.0	null
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.7634
RCC-JW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP2(20:3(8Z,11Z,14Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Phytosphingosine	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT3 (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GM2 (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
PI(22:5(7Z,10Z,13Z,16Z,19Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
PI(20:3(5Z,8Z,11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
PI(20:2(11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
anchoring	GeneRIF Biological Term Annotations	1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GM3 (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
PMC8448728__F5	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227863
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skin melanoma	GWASdb SNP-Disease Associations	1.0	1.83309
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GM1 (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.326067
K562_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166195
Ganglioside GM1 (18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD2 (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tetrahexosylceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
Colorectal Cancer	DisGeNET Gene-Phenotype Associations	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5565
PIP2(18:0/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(22:4(7Z,10Z,13Z,16Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
non-myelinating Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-562	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62495
MCF7_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0340233
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.7088
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18351
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SL-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77477
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27593
PI(18:0/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.9026
A549_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192856
Labyrinthine zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
Leading edge membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.6422
PIP(16:0/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT2 (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(20:4(5Z,8Z,11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
abnormality of the pharynx	GWASdb SNP-Phenotype Associations	1.0	1.75033
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.142
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22681
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622091
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.97986
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	133.515
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45978
ERG	ChEA Transcription Factor Targets	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829624
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
Ganglioside GQ1c (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
SHP77	DepMap CRISPR Gene Dependency	1.0	2.54553
PI(18:0/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43491
intrinsic component of endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
COPII-coated ER to Golgi transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.032754
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GT2 (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.1103
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE234289_3_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5697-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190316,GSE190324_10_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013866
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.32731
PIP(22:5(4Z,7Z,10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
A549_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138951
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Trihexosylceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887062
Ganglioside GQ1c (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
POU2F2	ENCODE Transcription Factor Targets	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15578
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311862
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.049558
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.971602
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996435
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
positive regulation of vasculature development	GO Biological Process Annotations 2025	1.0	null
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018668
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171674
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204651
zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.697748
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9987
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859991
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
MCF7_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196561
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154577_2_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PI(18:3(9Z,12Z,15Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AC-55-XA97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450782
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250284
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1484
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(18:2(9Z,12Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.29944
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64535
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903322
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.0462
A549_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164347
Ganglioside GD1b (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379286
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PIGK	Pathway Commons Protein-Protein Interactions	1.0	null
STK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10538
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_60_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8664-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5398
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417395
Ganglioside GD1b (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
PIP2(16:0/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
Post-translational modification: synthesis of GPI-anchored proteins	Reactome Pathways 2024	1.0	null
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.980229
RL	CCLE Cell Line Gene CNV Profiles	-1.0	-2.37865
ECGI10	CCLE Cell Line Gene Expression Profiles	-1.0	-2.30673
Phosphatidylinositol 3-kinase complex, class I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB-53-OL78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316993
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214546
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.2821
GTEX-QXCU-0626-SM-2TC69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862619
PIP2(16:1(9Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0281899
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.113
Cer(d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD2 (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.186
Ganglioside GM3 (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282013
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.50574
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_38_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(18:1(11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GM3 (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67496
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD2 (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.844396
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.795052
GSE180185_4_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mannosyl-diinositol-phosphorylceramide	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
c-terminal protein lipidation	GO Biological Process Annotations 2015	1.0	null
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB2	DepMap CRISPR Gene Dependency	1.0	2.33141
MCF7_Patupilone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153068
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP[3'](16:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
NR3C1	ChEA Transcription Factor Targets	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2322
ABAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12271
NCIH508	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71033
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-46-AX49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207075
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168799
Skin cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93634
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44459
GTEX-QXCU-0126-SM-2TC5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00298
PI(18:3(9Z,12Z,15Z)/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
PI(16:0/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
Vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.97
PI(18:1(9Z)/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26288
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.849
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.733
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2347	CCLE Cell Line Gene Mutation Profiles	1.0	null
PI(16:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017704
GTEX-RWS6-2426-SM-2XCB9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990344
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO Biological Process Annotations 2025	1.0	null
CCNYL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34842
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.86714
MAPK14_knockout_14_GDS2693	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.46199
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
TOV21G	CCLE Cell Line Gene Mutation Profiles	1.0	null
Ganglioside GD2 (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247096
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SM(d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.668699
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016145
PIP(18:1(9Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23873
PCI6A	DepMap CRISPR Gene Dependency	1.0	2.23531
endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.47696
PIP3(18:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05197
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4715
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05522
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874511
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198953
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34404
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198913
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13327
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30775
MCF7_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150339
LS	DepMap CRISPR Gene Dependency	1.0	2.29164
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341227
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.226607
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
5557_NDUFB5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.818622
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200524
MCF7_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022727
PIP2(18:1(9Z)/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
K562_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190542
PMC12619835-41467_2025_66007_MOESM12_ESM.xlsx-KLF5_activated_H3K27ac_T3M4-Nearest_Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151203
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37886
Ganglioside GT1c (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP2(16:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
AGS	DepMap CRISPR Gene Dependency	1.0	3.2467
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057157
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(20:3(5Z,8Z,11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11801
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166151
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.10089
integral component of organelle membrane	GO Cellular Component Annotations 2015	1.0	null
Ganglioside GT1b (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1a (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858927
Galactosylceramide (d18:1/14:0) 	HMDB Metabolites of Enzymes	1.0	null
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344513
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TERF2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0451
C21orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01788
A549_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146216
Ganglioside GT1c (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183546
PI(18:0/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.28188
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SH-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lactosylceramide (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
SMARCA4	ChEA Transcription Factor Targets	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8296523-13287_2021_2498_MOESM1_ESM.docx-0-sc-RNAseq_EGR1_cell_trajectory_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110174
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06261
Ganglioside GQ1c (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6526
MCF7_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149063
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3797
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156028
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957744
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.8201
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06648
Neuron projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.841
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.895873
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02198
PIP(20:3(8Z,11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.20511
Ganglioside GT1b (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9576
HCC1599	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58015
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gingival cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
PI(20:3(8Z,11Z,14Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bundle sheath cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
MCF7_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125979
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186448
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(20:4(5Z,8Z,11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIP(18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07374
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113879
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940003
TNIK_knockdown_297_GSE17623	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.54108
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.86638
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223816
u698	HPA Cell Line Gene Expression Profiles	-1.0	-0.888666
hsa-miR-504	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
K562_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155506
K562_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273501
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
PIP3(18:1(9Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07282
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuroectodermal tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ganglioside GD3 (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145415
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3-O-Sulfogalactosylceramide (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143787
SNU216	CCLE Cell Line Gene CNV Profiles	1.0	1.34868
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160017
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.369673
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Filiform apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.245
PI(22:4(10Z,13Z,16Z,19Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6551
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76959
K562_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149825
PIP(16:0/22:4(10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-P78B-1926-SM-3P616	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12486
MCF7_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129689
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42878
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68303
PI(18:1(11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
X31(H3N2)_12hour_None_GSE37245	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.64795
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11472
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.929677
PI(18:2(9Z,12Z)/20:0)	HMDB Metabolites of Enzymes	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13263
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1817
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.984497
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156122
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1824
A549_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155379
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36992
MCF7_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268957
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.880506
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04876
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832685
Neuroepithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278041
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8332
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
3869_HNRNPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.561184
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02206
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33505
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173409
HLF	CCLE Cell Line Gene Mutation Profiles	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14307
PIP2(18:0/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
DOV13	DepMap CRISPR Gene Dependency	1.0	4.56811
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4613
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266805
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52818
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51587
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0178
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8
BPH1	DepMap CRISPR Gene Dependency	1.0	3.81661
PIP(18:2(9Z,12Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU349	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66819
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.877106
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Toll-like receptor 2-Toll-like receptor 6 protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.194
PI(22:5(4Z,7Z,10Z,13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
Lobopodium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
Ganglioside GT1b (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
SKMG1	DepMap CRISPR Gene Dependency	1.0	2.83547
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11876
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08511
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.897412
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05907
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3515
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10197
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143286
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0317409
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
NTAQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36613
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	HPA Tissue Gene Expression Profiles	1.0	0.854448
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.795952
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Wound fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1778
PI(20:4(5Z,8Z,11Z,14Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152237
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3-Dehydrosphinganine	HMDB Metabolites of Enzymes	1.0	null
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.032279
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432166
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144936
Galabiosylceramide (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3941
3-O-Sulfogalactosylceramide (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	139.924
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220572
Galactosylceramide (d18:1/12:0) 	HMDB Metabolites of Enzymes	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187068
Galactosylceramide (d18:1/22:0) 	HMDB Metabolites of Enzymes	1.0	null
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ganglioside GD2 (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.91851
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
implicate	GeneRIF Biological Term Annotations	1.0	null
K562_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275377
L-741	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.63255
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67569
PIP(20:3(5Z,8Z,11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GPI anchor metabolic process	GO Biological Process Annotations 2025	1.0	null
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205641
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5194
MCF7_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169634
metabolic process	GO Biological Process Annotations 2015	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.84552
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154992
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269279
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015702
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206111
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.10635
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.318
attachment of GPI anchor to protein	GO Biological Process Annotations 2025	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.84452
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
catalytic complex	GO Cellular Component Annotations 2015	1.0	null
PI(18:0/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
FRTL-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pamoic Acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
Cutaneous melanoma or hair colour	GWAS Catalog SNP-Phenotype Associations 2025	1.0	10.0
Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.597245
MCF7_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217262
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87929
A549_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142826
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7823
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01141
PI(20:1(11Z)/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
GSE190316,GSE190324_6_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
carbohydrate derivative biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ganglioside GT2 (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-XMK1-2426-SM-4B66I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25073
Multiple congenital anomalies-hypotonia-seizures syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
Ganglioside GD3 (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11942
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
Mannan polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.997
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14948
GPI anchor binding	GO Molecular Function Annotations 2025	1.0	null
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224477
PIP2(20:3(5Z,8Z,11Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GT2 (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
GSE140997_4_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CIAO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56734
rectum	HPA Tissue Gene Expression Profiles	1.0	1.08392
Transitional cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GD1b (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199972
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166534
Galabiosylceramide (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT1c (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
A549_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160968
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.7728
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular response to mechanical stimulus	GO Biological Process Annotations 2025	1.0	null
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
primary motor cortex (area M1, area 4)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.65279
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33467
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.871616
RSU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12472
Ganglioside GD3 (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45071
21NT	DepMap CRISPR Gene Dependency	1.0	2.11898
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.77164
SARS-BatSRBD_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.60842
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.0343
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26333
GSE196117_1_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.6057
Ganglioside GT1c (d18:0/26:0)	HMDB Metabolites of Enzymes	1.0	null
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PIP(18:2(9Z,12Z)/20:0)	HMDB Metabolites of Enzymes	1.0	null
endothelial cell chemotaxis	GO Biological Process Annotations 2025	1.0	null
4926_MEAF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587006
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02092
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GD3 (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Galabiosylceramide (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT1b (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.5835
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17836
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
PIP(18:1(11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
melanoma	GWASdb SNP-Phenotype Associations	1.0	1.75033
A-2058 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
COTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22966
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-1592-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209631
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.475336
LOVO	DepMap CRISPR Gene Dependency	1.0	2.89267
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0368137
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39771
PI(22:4(10Z,13Z,16Z,19Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.946
GTEX-WYBS-0326-SM-3NM8S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0993
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30438
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R7-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fat_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.15614
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221378
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.758
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61925
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.3684
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.974897
3-O-Sulfogalactosylceramide (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
H376	DepMap CRISPR Gene Dependency	1.0	2.6577
PI(18:2(9Z,12Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
NCI-H2347	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238605
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02895
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82552
Cer(d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT1b (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018023
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29709
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.210615
PIP(16:0/22:5(7Z,10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
NCIH1568	CCLE Cell Line Gene Mutation Profiles	1.0	null
PIP(16:0/22:4(7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
PI(22:3(10Z,13Z,16Z)/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
PMC6770909__F1	PFOCR Pathway Figure Associations 2023	1.0	null
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23415
MCF7_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125159
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0161
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.77722
SW1271	CCLE Cell Line Gene Expression Profiles	1.0	2.2309
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12384
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.831497
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231597
Ganglioside GD3 (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70873
CAL148	CCLE Cell Line Gene Expression Profiles	1.0	1.71356
PAX5_OE_GDS4978_548_human_L428-PAX5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-0.95299
Fish- and plant-related diet	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.10969
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148609
Galabiosylceramide (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.835338
H2BC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14104
MTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51262
PI(22:3(10Z,13Z,16Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LS123	DepMap CRISPR Gene Dependency	1.0	2.55105
FOXP1	ChEA Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6XC-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11876
Cer(d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD2 (d18:1/26:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	281.262
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24473
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP2(20:4(5Z,8Z,11Z,14Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT1b (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Presynaptic density	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.521
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.991907
PI(20:3(5Z,8Z,11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14376
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137885
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cer(d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6181
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893255
Ganglioside GT3 (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKBR3	CCLE Cell Line Gene Expression Profiles	1.0	1.589
Ganglioside GM1 (18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49086
Ganglioside GD1b (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4487811-mmc3.xlsx-siRE_enriched_geneLists-siRE_occupancy_pattern_gene_lists_after_RUNX1_ETO_knock_down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ceramide (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD2 (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1a (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
Estimated glomerular filtration rate	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.6699
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
ERBB signaling pathway	GO Biological Process Annotations 2025	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-1426-SM-46MVW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875143
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1525
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.983113
Differentiated Thyroid Gland Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.922626
PI(18:0/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842979
NRBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.252
phosphatidylinositol biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367402
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48377
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.95428
L363	DepMap CRISPR Gene Dependency	1.0	2.14226
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00103
vasodilation	GO Biological Process Annotations 2025	1.0	null
SW1271	CCLE Cell Line Gene CNV Profiles	1.0	2.18523
SP1	ENCODE Transcription Factor Targets	1.0	null
Ganglioside GD3 (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
hsa-miR-4447	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29338
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953476
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Trihexosylceramide (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.73095
K562_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159733
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205765
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(18:1(9Z)/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
PIP2(18:1(9Z)/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
WD-08-QT63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279554
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11784
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08142
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sporophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP2(18:1(11Z)/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.94864
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157575
PDE7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27369
SRF_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(20:1(11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SM(d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185806
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158987
K562_Iniparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018519
Glucosylceramide (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
PI(16:1(9Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
BB-63-AW70_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338208
MDFI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09226
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.809276
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08059
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00647
GTEX-XAJ8-1226-SM-47JYS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938261
PIP2(18:1(11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.09059
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.933282
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210147
therapeutic	GeneRIF Biological Term Annotations	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29459
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08824
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194623
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212054
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18477
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8747
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24473
Integral component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-PX3G-2426-SM-48TZZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847267
DMS114	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42179
Ganglioside GM1 (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.3502
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233146
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
A704	CCLE Cell Line Gene Expression Profiles	-1.0	-2.97619
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15058
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.940041
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.969657
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TOV21G	DepMap CRISPR Gene Dependency	1.0	2.97884
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129439
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C2BBE1	CCLE Cell Line Gene CNV Profiles	1.0	1.41186
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.7888
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504869
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15293
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55297
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59308
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.779
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186902
CCT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17873
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165432
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170635
Ganglioside GT1b (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
Phytosphingosine-1-P	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT3 (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	173.105
Ganglioside GQ1c (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152346
6958_PUS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712935
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40053
Dichlorphenamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.182
KLF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92484
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48696
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215025
SM(d17:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22801
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839593
NAP1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75327
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XOT4-0326-SM-4B66S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03154
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165875
Glucosylceramide (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GM1 (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239241
PI(20:1(11Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.31009
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01046
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08051
neoplasm of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.528881
CTAGE15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63464
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3679
protein modification process	GO Biological Process Annotations 2015	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.842351
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0318851
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158243
PI(16:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ganglioside GD1a (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986728
D-502MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203944
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54562
estradiol_homo sapiens_gpl6947_gse27375	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237643
Ganglioside GM3 (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12119
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50902
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65657
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.645184
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
inferior frontal gyrus, opercular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32609
Glucosylsphingosine	HMDB Metabolites of Enzymes	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15538
Ganglioside GD2 (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1c (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240876
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.855133
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35087
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-1826-SM-2YUNI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11934
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90108
3-O-Sulfogalactosylceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
rectum_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.14704
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65093
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.540838
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38481
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.96882
K562_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150809
Ganglioside GD1a (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
QA-81-IM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231435
Multiple congenital anomalies-hypotonia-seizures syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.757
PI(16:0/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
A-Vietnam-1203-2004(H5N1)_2day-wtC57BL-6J_None_GSE40792	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.14863
PIP(18:2(9Z,12Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXF289	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74985
Ganglioside GD1b (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
17683608-TableS3	GeneSigDB Published Gene Signatures	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.74952
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.869533
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.528116
MCF7_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200759
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:1(11Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PIP3(16:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Glucosylceramide (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279973
Proteoglycans in cancer	KEGG Pathways 2026	1.0	null
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PI(20:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT3 (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81244
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34134
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834714
iPS-20b Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.15997
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67027
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Paroxysmal nocturnal hemoglobinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(18:0/22:5(7Z,10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.08695
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C11orf71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00039
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Procyclic form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017455
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesonephric duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1c (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9466
JHUEM-2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
K562_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253146
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12338
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3-O-Sulfogalactosylceramide (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1a (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RLE-6TN cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1241
Golgi cis cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.927
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07239
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180504
PIP2(20:2(11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cer(d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE270	CCLE Cell Line Gene Expression Profiles	1.0	1.78464
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GM2 (d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13292
oncogenic	GeneRIF Biological Term Annotations	1.0	null
Mifepristone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6176
HTT	ChEA Transcription Factor Targets	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ganglioside GM3 (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.6771
PI(16:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.9671
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288879
BHY	CCLE Cell Line Gene Expression Profiles	1.0	1.93867
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.9903
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.4924
TCF12	ENCODE Transcription Factor Targets	1.0	null
T-bar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967792
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37014
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0309588
GTF2B	ENCODE Transcription Factor Targets	1.0	null
COCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.968323
k1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.317
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(18:2(9Z,12Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	97.8
K562_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0282834
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.472
PIP2(18:1(9Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
TAF7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.46662
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4802
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
Ganglioside GT2 (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
PIP2(18:2(9Z,12Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.838493
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26077
A549_PFI-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134377
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122181
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tetrahexosylceramide (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
AB-10-RE65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344208
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17895
Caspase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6953
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03765
Ceramide (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43538
skin disease	GWASdb SNP-Disease Associations	1.0	1.46368
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.077
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58985
TORC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.522
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ganglioside GQ1c (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11876
PI(16:1(9Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.930183
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD1b (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD3 (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.62281
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8097
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.79932
colon_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.909158
Ganglioside GM1 (18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07918
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.95721
BT474	CCLE Cell Line Gene CNV Profiles	1.0	2.36415
K562_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237056
MOLP-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ganglioside GM2 (d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
PIP3(18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT3 (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04971
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1314
Obstructive sleep apnea_Hepatic Tissue_GSE1873	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.34604
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.559
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(18:1(9Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42922
Ganglioside GM2 (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
Waist-to-hip ratio adjusted for BMI x sex interaction	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
FNDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83312
PMC3874794__F2	PFOCR Pathway Figure Associations 2023	1.0	null
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210537
hsa-miR-4430	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TEAD4_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897507
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825236
GSE211829_9_v_1_tafasitamab_human	RummaGEO Drug Perturbation Signatures	1.0	null
3-O-Sulfogalactosylceramide (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XAJ8-0326-SM-47JYI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03953
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07569
PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0266373
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228161
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Trihexosylceramide (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948909
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167094
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD2 (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.859994
Ganglioside GT1b (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
KMRC3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77956
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
A549_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015849
Ganglioside GT1b (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039883
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BT474	CCLE Cell Line Gene Expression Profiles	1.0	2.65044
Lipid traits (pleiotropy) (HIPO component 1)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
Lactosylceramide (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cSARS Bat SRBD_24Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.34312
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integral component of Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6154-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981354
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PI(20:3(8Z,11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
melanoma; skin neoplasms	GAD Gene-Disease Associations	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE245270_2_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06148
BL-41 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.742
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51321
Glucosylceramide (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
A549_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177981
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6607
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
PIP(20:4(8Z,11Z,14Z,17Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT1c (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13774
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40166
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188044
WA-03-IF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227086
Hepatocellular carcinoma	KEGG Pathways 2026	1.0	null
cutaneous photosensitivity	GWASdb SNP-Phenotype Associations	1.0	1.29507
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cer(d18:0/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
CAOV-4	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GM3 (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Phosphatidylinositol 3-kinase complex, class II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.578
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36192
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	102.771
Sporozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.971
PI(18:0/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.996983
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59285
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.89897
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12154
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259376
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Osteoarthritis_Chondrocyte_GSE16464	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.80794
EP300	ENCODE Transcription Factor Targets	1.0	null
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888168
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.090537
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28277
PMC7618435-EMS211310-supplement-Table_S1.xlsx-C2-HSC_ELP_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13559
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.206975
SM(d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
HT	CCLE Cell Line Gene Mutation Profiles	1.0	null
SW1417	CCLE Cell Line Gene CNV Profiles	1.0	1.60731
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PMC10796137-cc9-6-e1030-s001.pdf-110-DPF3_DPF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
9535_UBL7_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559148
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EF-80-OD07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264323
KYSE270	CCLE Cell Line Gene CNV Profiles	1.0	1.49898
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1521
Ganglioside GM1 (d18:0/12:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16528
Ganglioside GT1c (d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42375
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.19103
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3675
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05309
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.2798
MCF7_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213766
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PI(16:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38026
SREBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SARS-BatSRBD_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.04323
Lung adenocarcinoma_LUAD_TCGA-91-6847-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H727	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
Melanoma	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.5114
Ganglioside GM3 (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176787
MITF	ChEA Transcription Factor Targets	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thyroid nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04862
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03913
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1869	DepMap CRISPR Gene Dependency	1.0	2.96911
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126463_4_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PI(18:1(9Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309997
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6588
Tetrahexosylceramide (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD3 (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
KYSE140	CCLE Cell Line Gene CNV Profiles	-1.0	-1.595
RUVBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26674
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242026
GSE84922,GSE84924_0_v_3_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14224
PMC12224833-12967_2025_6787_MOESM3_ESM.xlsx-DEGs_PDX1-GeneSymbol_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Inositol-P-ceramide	HMDB Metabolites of Enzymes	1.0	null
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1527
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZN-1026-SM-4DXTC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02671
Ganglioside GM3 (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997078
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10228
hel	HPA Cell Line Gene Expression Profiles	1.0	1.26953
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342156
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1365
PIP2(18:1(11Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66457
PIP(16:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GM2 (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
UBLC1	DepMap CRISPR Gene Dependency	1.0	2.37657
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21286
Vilanterol_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250135
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell-cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PIP2(18:2(9Z,12Z)/20:2(11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984019
MCF7_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0109049
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08309
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17575
NB6	DepMap CRISPR Gene Dependency	1.0	2.34568
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328759
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54966
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6885
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8869
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.96
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18294
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0327474
LTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07243
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.2696
MCF7_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168946
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9663
RPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14787
protein lipidation	GO Biological Process Annotations 2015	1.0	null
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COQ8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19087
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Trihexosylceramide (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38263
Ganglioside GD1a (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
Sporocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.461
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.525
PI(20:2(11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
A549_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156271
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52547
OV56	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46364
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152195
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46422
protein complex	GO Cellular Component Annotations 2015	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.261
Lung adenocarcinoma_LUAD_TCGA-73-4662-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182728
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52648
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.1549
K562_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242192
PI(20:1(11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GPR161	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16148
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.97673
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2807
mRNA_YY1_22210892	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840462
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
temporal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20279
RUNX3	ENCODE Transcription Factor Targets	1.0	null
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206181
Ganglioside GT1c (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18175
SM(d18:1/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Cutaneous Melanoma	DisGeNET Gene-Disease Associations	1.0	null
integumentary system cancer	GWASdb SNP-Disease Associations	1.0	0.622745
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04239
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.982937
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.52735
GTEX-RTLS-0326-SM-2TF6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842245
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell chemotaxis	GO Biological Process Annotations 2025	1.0	null
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11871
GTEX-WY7C-2626-SM-3NB2P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90427
MCF7_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158149
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39295
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
COPII vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.205
GSE152441,GSE152442_1_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148384
Ganglioside GM2 (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930487
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
786O	CCLE Cell Line Gene Mutation Profiles	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.266608
Ganglioside GD1a (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
PI(18:2(9Z,12Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_99_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186307
A549_Roxadustat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133191
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50291
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISTMES2	DepMap CRISPR Gene Dependency	1.0	2.23809
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EKVX	DepMap CRISPR Gene Dependency	1.0	3.24677
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Clc cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GM2 (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
SRF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6YC-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69783
HUPT4	CCLE Cell Line Gene Mutation Profiles	1.0	null
PIGS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PI(18:1(11Z)/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928469
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213988
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW1463	CCLE Cell Line Gene Expression Profiles	1.0	1.47765
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nih-3t3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.404418
HCV JFH1_120Hour-Huh7_5_1_None_GSE29889	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.57185
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATF3_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06256
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.149358
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cloned cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
Lung adenocarcinoma_LUAD_TCGA-05-4432-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41654
Ganglioside GM2 (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.860857
Ganglioside GT2 (d18:0/25:0)	HMDB Metabolites of Enzymes	1.0	null
PI(16:0/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cer(d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
HDAC2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GQ1c (d18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208568
PMC10594727-13062_2023_428_MOESM14_ESM.xlsx-Sheet1-PPARD_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895836
Ganglioside GT1c (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8945
GSE169152_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5029-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22882
HGH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32336
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.91103
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y1-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW1271	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
Ganglioside GM1 (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
PLA2G4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13668
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8129
HEPG2	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.61213
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04607
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.18755
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151782_4_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ER-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.278
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39215
Cer(d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lactosylceramide (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
SLR24	DepMap CRISPR Gene Dependency	1.0	2.74345
PIP(18:1(9Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42673
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882255
phospholipid binding	GO Molecular Function Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PI(16:0/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperphosphatasia with impaired intellectual development syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ganglioside GT1c (d18:1/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
A549_Bisindolylmaleimide IX_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177354
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD3 (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881913
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5178
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010088
ATF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55416
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
PIP(18:1(9Z)/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18354
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ganglioside GT2 (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92246
PIP2(18:1(11Z)/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GM1 (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
HCC1954	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69959
PIP2(18:1(11Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
PIP2(20:2(11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
Protein C Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.5623
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SM(d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
K562_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199295
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840078
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
werirb1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840872
cingulate gyrus, parietal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.927187
PI(20:0/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
TUFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09567
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0403711
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.8913
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28528
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.942063
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88027
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.20742
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15246
Ganglioside GD1b (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38419
hydrocephaly	MGI Mouse Phenotype Associations 2023	1.0	null
NUGC3	CCLE Cell Line Gene Expression Profiles	1.0	2.03371
JHUEM7	CCLE Cell Line Gene Mutation Profiles	1.0	null
PI(18:1(9Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC812	CCLE Cell Line Gene CNV Profiles	1.0	1.38664
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183548
E2F1	ENCODE Transcription Factor Targets	1.0	null
Pulmonary microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
PI(18:2(9Z,12Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.66264
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350725
Estimated glomerular filtration rate in non-diabetics	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDLM2	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24614
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.04264
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-8067-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09736
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157383
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74885
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9026
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.75954
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98985
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26385
BT-474	COSMIC Cell Line Gene CNV Profiles	1.0	2.30944
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27703
K562_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014837
GTEX-PSDG-0626-SM-2S1OE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979871
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37603
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932534
FU-OV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PI(20:3(5Z,8Z,11Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD1b (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.884067
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44578
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22919
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5108
Ganglioside GT2 (d18:0/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139893
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZQ-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ganglioside GT2 (d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PF-39-DY68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208766
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12229
Ganglioside GD1a (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMS-114 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCK81	CCLE Cell Line Gene Mutation Profiles	1.0	null
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2025	1.0	null
Oily fish consumption	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.81549
GSE154577_6_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194181
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12744
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.337237
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35729
PIP2(18:1(11Z)/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74568
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38903
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139396
PMC8088646-13148_2021_1081_MOESM1_ESM.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125153_2_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PIP(18:1(9Z)/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
PIP2(16:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.21497
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Recurrent Tumor	DisGeNET Gene-Phenotype Associations	1.0	null
Grb2-Shc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.718
MCF7_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150284
SRF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4X-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017291
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947244
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36486
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834714
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145444
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03849
Rough endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.792
regulation of jak-stat cascade	GO Biological Process Annotations 2015	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0626-SM-2S1PV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23476
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.0136
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250152
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.007
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Ganglioside GM2 (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13499
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HK2	CCLE Cell Line Gene Expression Profiles	1.0	1.40154
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190463
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881681
Ganglioside GM1 (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12768
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45086
MCF7_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125237
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood vessel diameter maintenance	GO Biological Process Annotations 2025	1.0	null
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74139
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1b (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.883548
PIP(18:0/18:3(9Z,12Z,15Z))	HMDB Metabolites of Enzymes	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35755
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02801
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.758299
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0311368
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6045
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.5907
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04403
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93726
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9011
Ceramide (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900683
GTEX-P4QS-1326-SM-3NMCD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838713
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT1b (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1243
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LB2518-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PI(16:0/22:4(10Z,13Z,16Z,19Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD2 (d18:0/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141064
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959099
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fasudil_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194271
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1195
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIP(20:3(5Z,8Z,11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103255
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0334687
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP2(18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0655
HCC-4006 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
dactinomycin_mus musculus_gpl6246_gse21233	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120745
PIP(20:2(11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GD3 (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
MCF7_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217481
GSE186112_1_v_0_med23_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A7EU-01A-22R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7262
Ganglioside GQ1c (d18:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.940467
nerve	GTEx Tissue Gene Expression Profiles	1.0	1.42471
HDAC2	ENCODE Transcription Factor Targets	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5641
DNASE1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79493
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
Ganglioside GD3 (d18:0/23:0)	HMDB Metabolites of Enzymes	1.0	null
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPI-anchor transamidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.009
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22763
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218127
Ganglioside GM2 (d18:1/12:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14795
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06738
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11639
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP2(20:1(11Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GM1 (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0489519
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86937
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825779
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51867
Ganglioside GT3 (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300824
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13163
PIP2(18:1(11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
NCAPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13215
PIP(18:2(9Z,12Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231438
SM(d19:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
Cer(d18:0/22:1(13Z))	HMDB Metabolites of Enzymes	1.0	null
protein c deficiency	GWASdb SNP-Disease Associations	1.0	2.9288
Ganglioside GT2 (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
253J	DepMap CRISPR Gene Dependency	1.0	2.37329
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24075
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1194
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838105
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173194
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.30922
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6607
fusiform gyrus, right, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10314
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20464
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0632
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
PIP3(18:1(11Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42666
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199494
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251361
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27907
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH322	CCLE Cell Line Gene CNV Profiles	1.0	1.55226
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.96595
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GT2 (d18:1/23:0)	HMDB Metabolites of Enzymes	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183912
TRAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14839
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00863
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
bladder	GeneRIF Biological Term Annotations	1.0	null
inner CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04728
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19353
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2376
PIP2(18:1(9Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP(20:2(11Z,14Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56863
K562_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0486297
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.60375
Ganglioside GM2 (d18:1/9Z-18:1)	HMDB Metabolites of Enzymes	1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.830086
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
SM(d18:0/14:0)	HMDB Metabolites of Enzymes	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
A-431 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.029
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	47.2999
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57159
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05954
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PI(18:1(11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
A549_PCI-34051_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113368
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	1.86044
Ganglioside GM3 (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4161
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88411
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205983
Ceramide (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
A549_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236395
PIP(16:1(9Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PMC11211849-btae257_supplementary_data.pdf-13-MLXIPL_MLXIPL	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201004
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2725
abnormality of the nasopharynx	GWASdb SNP-Phenotype Associations	1.0	1.75033
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2703-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP2(22:3(10Z,13Z,16Z)/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02968
PIP2(20:2(11Z,14Z)/18:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(20:1(11Z)/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341515
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the coagulation cascade	GWASdb SNP-Phenotype Associations	1.0	2.90452
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71598
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.1843
Ganglioside GD2 (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181665
Swine testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
A549_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153949
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ganglioside GQ1c (d18:1/22:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82824
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26552
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224283
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79011
Medial entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8945
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.95736
CRCGN016_MCF10A.TP53.M_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03782
Ganglioside GM2 (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
HS888T	CCLE Cell Line Gene Mutation Profiles	1.0	null
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8982
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI(18:1(11Z)/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(20:3(8Z,11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13507
PIP(18:1(9Z)/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231163
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175234
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00829
PIP2(20:3(8Z,11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.898074
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222703
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165113
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26698
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991829
Ganglioside GD1a (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
Signal recognition particle receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.869
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.83823
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.39
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP(20:2(11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12584
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64099
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239211
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Herring body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.582
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skbr3	HPA Cell Line Gene Expression Profiles	1.0	1.58318
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-2026-SM-2S1OD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891295
PIP(16:2(9Z,12Z)/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.752695
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_64_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024038
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE135400_2_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.9559
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Papillary thyroid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.046
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.80597
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TP-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.751195
Natural killer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24385
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
GTF2A1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78738
N-Lignoceroylsphingosine	HMDB Metabolites of Enzymes	1.0	null
PIP2(20:3(8Z,11Z,14Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327453
MRPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57537
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9209555-12288_2021_1474_MOESM1_ESM.docx-0-NFKB1_NFKB1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023269
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4597
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIP2(18:2(9Z,12Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849945
ELF1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826363
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC-827 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
Ganglioside GT1c (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_Patupilone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160134
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9878
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.97
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
7091_RANBP10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619742
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876861
NK-92 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.016
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05366
K562_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201682
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162613
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NANOG	ENCODE Transcription Factor Targets	1.0	null
K562_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167724
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211357_2_v_0_atg7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.58846
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325865
SMAD4	ChEA Transcription Factor Targets	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14983
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.97433
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20101
ZFP42	ChEA Transcription Factor Targets	1.0	null
MCF7_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131806
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WD-62-UB45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248388
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.52061
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE245270_2_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79263
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08217
PAX5	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32465
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBM15_02_143	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.5898
K562_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276637
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152301
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-2326-SM-2XCB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35081
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GD2 (d18:1/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
MCF7_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241091
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lactosylceramide (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-POYW-0426-SM-2XCEV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88817
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	163.651
GTEX-TML8-1626-SM-32QOO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916381
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294143
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08
Synergid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.02
PI(22:2(13Z,16Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
K562_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166013
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Fatty acid elongase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.509
HT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-1826-SM-2S1PE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12436
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170016
PIP(20:4(5Z,8Z,11Z,14Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.838106
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210767
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140381
integral component of endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36386
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.887849
system	GeneRIF Biological Term Annotations	1.0	null
GTEX-U8XE-0526-SM-3DB8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6579
KYSE520	CCLE Cell Line Gene Mutation Profiles	1.0	null
Ganglioside GD1b (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
glycosylphosphatidylinositol-mannosyltransferase I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.311
MCF7_Epothilone A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129847
MCF7_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272191
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09344
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.98756
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191446
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
SM(d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
Golgi cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1785
outer SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42593
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Epilepsy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
TCF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27897
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.30275
Hemoglobinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
Ganglioside GD1a (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55385
ARSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.744
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5594
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5222
PMC3348545-NIHMS263168-supplement-3.pdf-8-PLAGL2_PLAGL2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291889
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208364
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.527
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6736
Scoliosis, Unspecified	DisGeNET Gene-Disease Associations	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.90593
PIP2(18:0/20:4(8Z,11Z,14Z,17Z))	HMDB Metabolites of Enzymes	1.0	null
Cell type cancer	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215064
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
outer SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.904413
MCF7_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188696
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11876
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180782
PIP2(16:0/22:2(13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hepg2	HPA Cell Line Gene Expression Profiles	1.0	0.907205
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
cisplatin_homo sapiens_gpl570_gse23553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.88003
PIP3(16:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GPRASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39581
Ganglioside GD1b (d18:0/22:0)	HMDB Metabolites of Enzymes	1.0	null
PIP(20:1(11Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.9944
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Developmental and epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
HRT18	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18888
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
Ganglioside GT3 (d18:1/24:1(15Z))	HMDB Metabolites of Enzymes	1.0	null
PI(18:1(9Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11591
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01379
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(20:3(5Z,8Z,11Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
CHIME syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-0726-SM-48TDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18861
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979943
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3254
Skin carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.524
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6219-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Slit-Robo signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.642
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP3(18:1(9Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025039
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155789
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
PIP(20:3(8Z,11Z,14Z)/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.86975
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6341466__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Ganglioside GM3 (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982765
GSE130715_1_v_0_budesonide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02643
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08309
Glucosylceramide (d18:1/20:0)	HMDB Metabolites of Enzymes	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.492777
PIP(16:2(9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.658161
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35095
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025881
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.131018
Height	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.930103
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
PIP2(16:0/22:5(4Z,7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.363
GTEX-U3ZH-1626-SM-3DB74	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0914
PIP2(20:4(5Z,8Z,11Z,14Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0353
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19658
PIP2(16:2(9Z,12Z)/22:3(10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958619
N-Glycoloylganglioside GM1	HMDB Metabolites of Enzymes	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1283
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061557
K562_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156709
PIP(18:1(11Z)/20:4(5Z,8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.838106
Wop	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
K562_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204408
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BIM-BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.017
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IGF1R_druginhibition_47_GSE14024	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.20612
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188658
Ganglioside GD2 (d18:1/24:0)	HMDB Metabolites of Enzymes	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15631
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052862
MK-3903_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204245
PIP(18:0/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
DB-11-SS01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25773
SAP130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16817
organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ganglioside GT1c (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GD3 (d18:1/16:0)	HMDB Metabolites of Enzymes	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.3713
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25108
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987031
Ganglioside GM2 (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
neoplasm by histology	GWASdb SNP-Phenotype Associations	1.0	0.369081
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4695
LI7	DepMap CRISPR Gene Dependency	1.0	2.9161
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.867896
Disease of cellular proliferation	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
gpi-anchor transamidase activity	GO Molecular Function Annotations 2015	1.0	null
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955073
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997522
Ganglioside GD2 (d18:1/18:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ganglioside GQ1c (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436501
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276367
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06245
PI(18:1(9Z)/18:3(6Z,9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14362
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
CTCFL	ENCODE Transcription Factor Targets	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GM2 (d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPI anchor biosynthetic process	GO Biological Process Annotations 2025	1.0	null
PIP(16:1(9Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193436
GTEX-Q734-1126-SM-48TZY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07309
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	190.155
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140965_2_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195899
PI(18:2(9Z,12Z)/18:0)	HMDB Metabolites of Enzymes	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06095
GSE161302,GSE161304_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01026
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.867
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE154577_2_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIP(16:1(9Z)/18:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.943667
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
PIP2(16:0/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1757
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250135
MCF7_Rigosertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132761
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFX	ChEA Transcription Factor Targets	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7974
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.943916
HTT-18923047-STHdh-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2648
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5349
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34044
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30866
ZBTB33_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4032
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116810_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129134
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06643
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9304
KMBC2	CCLE Cell Line Gene CNV Profiles	1.0	1.6363
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335597
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.21963
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ganglioside GQ1c (d18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.431735
PI(20:3(5Z,8Z,11Z)/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019961
PI(20:4(5Z,8Z,11Z,14Z)/20:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(18:0/16:2(9Z,12Z))	HMDB Metabolites of Enzymes	1.0	null
PIP(18:0/16:1(9Z))	HMDB Metabolites of Enzymes	1.0	null
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180292
MCF7_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204384
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945026
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213098
Mammary epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.128
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4804
PIP(16:0/20:3(8Z,11Z,14Z))	HMDB Metabolites of Enzymes	1.0	null
Ganglioside GT1b (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30771
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00575
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02051
Ganglioside GT2 (d18:1/26:1(17Z))	HMDB Metabolites of Enzymes	1.0	null
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153593
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212415
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986979
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3019
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60396
PIP3(18:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Integral component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.904
K562_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344878
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of angiogenesis	GO Biological Process Annotations 2025	1.0	null
ESR1	JASPAR Predicted Transcription Factor Targets	1.0	null
Metabolism of proteins	Reactome Pathways 2024	1.0	null
Glucosylceramide (d18:1/25:0)	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PI(18:0/18:0)	HMDB Metabolites of Enzymes	1.0	null
PIP(20:4(8Z,11Z,14Z,17Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168911
positive regulation of blood vessel endothelial cell migration	GO Biological Process Annotations 2025	1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GD1b (d18:1/26:0)	HMDB Metabolites of Enzymes	1.0	null
GSE151782_4_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4777
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of receptor signaling pathway via JAK-STAT	GO Biological Process Annotations 2025	1.0	null
LXF289	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62529
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487195
miR-142-3p_OE_GSE28456_470_human_Raji cells (B lymphocytes)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.5056
UBTF	ENCODE Transcription Factor Targets	1.0	null
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93813
ATF1	ENCODE Transcription Factor Targets	1.0	null
SLC35E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3758
PIP(18:2(9Z,12Z)/20:3(5Z,8Z,11Z))	HMDB Metabolites of Enzymes	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.52822
ELF1	ChEA Transcription Factor Targets	1.0	null
Ganglioside GM3 (d18:0/20:0)	HMDB Metabolites of Enzymes	1.0	null
MCF7_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020012
SM(d18:0/24:0)	HMDB Metabolites of Enzymes	1.0	null
PIP2(16:0/16:0)	HMDB Metabolites of Enzymes	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865719
NB69	DepMap CRISPR Gene Dependency	1.0	4.07668
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10718
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63663
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.91393
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.9675
GSE196505,GSE196507_3_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921117
PIP(16:0/18:1(11Z))	HMDB Metabolites of Enzymes	1.0	null
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23562
Cerebellar Hypoplasia	DisGeNET Gene-Disease Associations	1.0	null
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.5533
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186308
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69971
PIP2(16:0/22:4(7Z,10Z,13Z,16Z))	HMDB Metabolites of Enzymes	1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11547
SF172	CCLE Cell Line Gene Expression Profiles	1.0	1.56169
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874288
Flag leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglioside GQ1c (d18:1/14:0)	HMDB Metabolites of Enzymes	1.0	null
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PI(16:2(9Z,12Z)/16:0)	HMDB Metabolites of Enzymes	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null