association	dataset	threshold value	standardized value
Perturb_9941_KD_MBNL1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.62986
Epicuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2327
quality	GeneRIF Biological Term Annotations	1.0	null
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.00979
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214329
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS35	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32533
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SKOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42715
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CE-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8108-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249062
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-1626-SM-47JYN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938944
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZF-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.836239
BRD-K85627183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31823
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23139
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.836475
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4301_KCTD10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523252
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6225
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.63227
GTEX-T6MN-0726-SM-32PML	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11454
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20923
uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.256
BRD-K01237500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05097
angiotensin type II receptor activity	GO Molecular Function Annotations 2025	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.16434
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R9-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.972
Central vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01877
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.930474
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0927
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_9010_KD_RELA_SRP061289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.00691
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.85087
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.48226
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_12028_OE_ID3_SRP333901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.51391
PMC4728380-ncomms10153-s11.xlsx-M5075-SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6978-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS22	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4800-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-merged_Gene_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Multiple mitochondrial dysfunctions syndrome 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.514
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
tilmicosin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08485
Perturb_3856_KD_CMTM6_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.44101
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3699
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997631
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50422
spinocerebellar degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.60108
hsa-miR-4453	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8333
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890695
BRD-K58432332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92697
CNOT3-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.2222
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04792
BRD-K69569958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46874
BRD-K45503385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42914
BRD-K18737347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23302
hsa-miR-3919	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05541
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37478
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERG	ChEA Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-DX-A3M1-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
single-organism cellular localization	GO Biological Process Annotations 2015	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.858503
peptidase activity	GO Molecular Function Annotations 2015	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946465
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824194
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1465
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-5869-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04272258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20811
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859398
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36877
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Unnamed_1_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Crown gall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.67
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NEDD8	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34095
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9935_KD_ATP5F1C_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.12564
BRD-K91766181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91226
BRD-K88281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21432
MRPL46	Pathway Commons Protein-Protein Interactions	1.0	null
HslUV protease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.138
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4516
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50893
PMC8190596-mmc2.xlsx-RUNX1_mut-RUNX1_mut_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149264,GSE149267_2_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NOMO1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.5187
SETDB1	ENCODE Transcription Factor Targets	1.0	null
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_555_KD_PHF2_SRP277893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.0711
Brain Lower Grade Glioma_LGG_TCGA-FG-8186-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
germ layer	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
cytoplasmic transport	GO Biological Process Annotations 2015	1.0	null
GSE149075_1_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4968
WTAP	Pathway Commons Protein-Protein Interactions	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE88819_5_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1066	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0798
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.6567
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.873018
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42508877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39136
GSE229468,GSE229471_2_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
translocation	GeneRIF Biological Term Annotations	1.0	null
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7932_KD_Spt6_SRP132004	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.1824
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264665
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41012
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519295
peptidase activity, acting on l-amino acid peptides	GO Molecular Function Annotations 2015	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15626
single-organism process	GO Biological Process Annotations 2015	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-28-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68148
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37544
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283687
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338045
NPHP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K84054400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32977
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
Perturb_7306_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.2041
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
DA-69-UN88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208075
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08634
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78886448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43957
CHCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
magnocellular (medial) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35755
H3255	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Charcot-Marie-Tooth disease type 2A2A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
BRD-K43017905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39156
Perturb_10716_KO_Mtx2_SRP404364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.8539
C32	GDSC Cell Line Gene Expression Profiles	1.0	1.4657
B-lymphocyte	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.829802
Perturb_17612_OE_MYC_SRP301619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.88713
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13959_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.92839
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GRPEL1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10097_KD_CNOT8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.9935
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_2054_KD_CHERP_SRP354316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.34823
Osteolysis_Leukocyte - Lymphocyte - B-Lymphocyte - Plasma Cell (MMHCC)_GSE755	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.59665
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08322
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00101
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.3311
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-XYKS-0926-SM-4BRVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62578
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
upregulation	GeneRIF Biological Term Annotations	1.0	null
BRD-K26423054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51785
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5U8-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874448
ATF2	ENCODE Transcription Factor Targets	1.0	null
YARS2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-140-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YH-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6638
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9186
BRD-K33453127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08845
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00312
MFE-296	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.28344
USP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49252
ETFA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76921877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35101
Perturb_13683_KD_FTO_SRP116935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.62177
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPID	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540285
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU1105	Achilles Cell Line Gene Essentiality Profiles	1.0	1.0975
Hyperplasia	CTD Gene-Disease Associations	1.0	1.32192
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260376
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902645
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21308
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06596
Perturb_8240_KD_SF3B4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.11204
CHD2	ENCODE Transcription Factor Targets	1.0	null
Perturb_452_OE_MYC_SRP171977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.5863
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3406
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97876
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.2032
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47816
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.256
SU-DHL-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.50383
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57114
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838922
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864323
3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
KM12	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.17944
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.34534
COQ2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904749
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3667-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K79303560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60629
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenalgland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.999995
SSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06157
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03053
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.22136
Perturb_9402_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80878
HOS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80978
GTEX-X261-0011-R5A-SM-3NMB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859898
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.4446
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G protein-coupled peptide receptor activity	GO Molecular Function Annotations 2025	1.0	null
A-CA-04-2009(H1N1)_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.38884
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
SETD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00317
colon	HPA Tissue Protein Expression Profiles	-1.0	-0.764232
Perturb_3748_KD_NORAD_SRP149071	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.62901
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44051
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_2-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46592
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31296
gemcitabine_homo sapiens_gpl96_gse6914	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K95864593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51713
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7276
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14627
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0833
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.590607
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CODAS syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.086
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58331
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	1.33732
GTEX-VJWN-0626-SM-3NMAN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912747
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827385
Perturb_13902_KO_AS3MT_SRP332674	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.45796
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.062
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.4575
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27213
SARS-BatSRBD_72Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.2417
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16583
NCIH1299_LUNG	CCLE Cell Line Proteomics	1.0	2.69082
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.863798
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12889_KO_Chaf1b_SRP161931	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.497
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7819
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RX-A8JQ-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.24259
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39927
PMC10117376-hmg-2022-ce-00467_r1-sollis-supptables_ddac311.xlsx-TS1_AP-MS_results-Table_S1_TBR1-interaction_candidates_identified_in_two_AP-MS_experiments_TBR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67508052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03884
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63706
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45116
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9945_KD_UTP18_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.51093
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85105
KG1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.04135
BRD-K40685792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54393
ATP5L	Pathway Commons Protein-Protein Interactions	1.0	null
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.171
SUPV3L1	Pathway Commons Protein-Protein Interactions	1.0	null
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.921549
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37892442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77613
HDAC2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941235
GTEX-NPJ8-0011-R4a-SM-2HML3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0873
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055154
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7763_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.9481
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K78119702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29231
ATL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9575
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRPL28	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4314	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
layer III of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846497
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39979888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13149
Polyphosphate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.517
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K41809155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32407
GSE201042_2_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLPSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01628
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4362
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891576
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.21668
RPUSD3	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997248
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.20187
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.896794
GTEX-T6MO-0126-SM-4DM6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24868
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.586482
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03176
hsa-miR-3647-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.81868
CTCF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846348
BRD-K32913479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26012
Perturb_2308_KD_DHX8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.35297
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044289
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial protein import	Reactome Pathways 2014	1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998905
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.19835
PBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6531
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH292_LUNG	CCLE Cell Line Proteomics	1.0	2.98622
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1846
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94082
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_homo sapiens_gpl96_gse4668	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-QCQG-0526-SM-48U2A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874779
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X2-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2639
endopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
TRIM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72622
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_13022_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
primary motor cortex (area M1, area 4)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.982039
hsa-miR-1228	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10626
Perturb_2730_KD_BCL11A/MBNL1_SRP258724	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.16313
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Hypertrophic cardiomyopathy 26	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.752
CL11	CCLE Cell Line Gene CNV Profiles	1.0	1.48274
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4513	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SOX17	ChEA Transcription Factor Targets	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.02404
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aconitine-1784	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUCLA2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87465930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16851
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.993003
Peroxisomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-4022-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.11507
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.86212
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25379
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.33838
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06121
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLAD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC-827 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
Infertility, Male	CTD Gene-Disease Associations	1.0	1.72633
SALL4	ChEA Transcription Factor Targets	1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09026
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0449
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.925715
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein targeting to mitochondrion	GO Biological Process Annotations 2023	1.0	null
CALU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27915
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22465
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1192
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.689
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BTK_knockout_2_GDS1346	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.098027
T-lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_599_OE_HOTAIR_SRP342161	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.477
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Penis_Foreskin_Keratinocyte_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.17131
BRD-K66324291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07259
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-2026-SM-3NB1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836087
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1021
BRD-K52876244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59036
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL24	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-144	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61416283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81699
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86873
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5512
Perturb_1367_KD_IGF2BP1_SRP252209	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.28769
Perturb_6004_KD_CEBPZ_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927597
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VB-89-RG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243857
HCC2814	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.17798
VDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35546
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine Neoplasms	CTD Gene-Disease Associations	1.0	1.02858
Perturb_8450_KD_NPM1_SRP230777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.86388
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hs-578Bst cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vegetative cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.612152
Fatty Liver	CTD Gene-Disease Associations	1.0	1.65336
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00353
BRD-K86623758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67562
pnpt1	GeneRIF Biological Term Annotations	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Perturb_9670_Mut_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.60207
Mitochondrial protein import	Reactome Pathways 2024	1.0	null
Perturb_3791_KD_KCNK1_SRP057613	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.11772
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907167
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17029
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08189
Perturb_11467_KD_SRSF1_SRP290964	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MST cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4065
BRD-K28039328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5501
BRD-K16862492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38099
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MESSA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59904
BRD-K24025166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07139
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901796
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20051
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495472
MRPS15	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40210962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10342
MXI1	ENCODE Transcription Factor Targets	1.0	null
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.948455
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42743
HEP3B217_LIVER	CCLE Cell Line Proteomics	1.0	5.1315
Sebum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07916
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52713598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11719
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8759
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.739377
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24127
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231789
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89296
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23569
Perturb_5353_KO_Dux_SRP201141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.07877
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HS578T	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.896732
IPC-298	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1937	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.79713
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1548
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12531686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00079
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839849
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8115
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Auditory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.83
ME-180	GDSC Cell Line Gene Expression Profiles	-1.0	-1.78957
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77O-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Poor Head Control	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_14374_KD_SRF_SRP150935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.77244
GTF2B	ENCODE Transcription Factor Targets	1.0	null
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_9669_KO_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.22227
CAL-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LOVO	CCLE Cell Line Gene Expression Profiles	1.0	1.5065
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63383
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
MET_knockout_260_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.67849
PPARD_KO_GSE16048_54_mouse_pancreas (islets, PDX1-expressing cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28264750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03574
Perturb_7699_KD_SKIIP_SRP155347	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.00556
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054585
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506728
Lung squamous cell carcinoma_LUSC_TCGA-85-8277-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875118
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.09462
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.067
MOLT-4 cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJMC-0226-SM-4IHLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14278
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3158-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02218
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26858
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Perturb_9400_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.22971
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062394
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.598734
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K28923989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12486
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11024
LU99	CCLE Cell Line Gene CNV Profiles	-1.0	-2.80833
Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metallopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
kidney_b	HPA Tissue Sample Gene Expression Profiles	1.0	1.13464
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.849557
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WYVS-1726-SM-3NMAY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01473
BRD-K89469595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22077
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227031
Calu-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48184
A549_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136774
CEBPB_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_mus musculus_gpl1261_gds2802	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
mitochondrial part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.256197
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
GTEX-NPJ8-0011-R2a-SM-2TC6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04316
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044964
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	1.0	1.21668
Ankylosing Spondylitides_macrophage_GSE11886	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.41319
CB-82-PL01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216849
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63387
hsa-miR-2115	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K60713831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5122
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7786
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15208
LONP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K50400833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24994
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8372
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860245
HIBADH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37271
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87625
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMMY-0726-SM-33HBE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35262
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3217
BRD-K66479240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38802
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0S7-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-SNU-5	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
connecting stalk	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.049
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932194
BL3627 (KDM3A)	NURSA Protein Complexes	1.0	null
GTEX-PWCY-0726-SM-48TCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931492
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.914825
Combined oxidative phosphorylation deficiency 49	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7843
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
BL41	CCLE Cell Line Gene Expression Profiles	1.0	1.45155
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25629
respiratory chain complex iii	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.672894
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4077
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6478-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3695
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.864414
HT-1376	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.9709
Brain Lower Grade Glioma_LGG_TCGA-HT-8114-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85961
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.72925
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.03752
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.854149
Heart valve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.034
Charcot-Marie-Tooth disease type X	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934108
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23474
BRD-K18262761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15649
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.900752
BHT-101	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.73633
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215845
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1725
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45631
Peptidase M16, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18533510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10873
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9306
MGME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04875
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06067
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31486
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04501
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein processing involved in protein targeting to mitochondrion	GO Biological Process Annotations 2023	1.0	null
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.8579
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427798
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15161
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15468_KD_TCEAL1_ERP123632	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.63814
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6583
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0098
BRD-A69786436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04059
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43152
GTEX-T6MO-1626-SM-32QOM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965733
GSE154069_2_v_4_satb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.077
hsa-miR-501-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829617
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896911
Feeding Difficulties	DisGeNET Gene-Phenotype Associations	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.942219
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66672
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827893
GSE96991,GSE97117_5_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
17616640-TableS3	GeneSigDB Published Gene Signatures	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4701
EBC1	CCLE Cell Line Gene Expression Profiles	1.0	2.951
intracellular part	GO Cellular Component Annotations 2015	1.0	null
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044803
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06106
BRD-K37866276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20444
Perturb_10011_KD_AARS1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.1235
ZR7530	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33186
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24263
hsa-miR-323b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11201
DLD1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.63206
hsa-miR-520f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
WC-67-DI84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243451
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.23584
BRD-K32406588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07525
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.59806
Microbody lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.585
GTEX-UPIC-0326-SM-4IHJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907231
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9167
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548e	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927515
CAS1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.16748
IPC298_SKIN	CCLE Cell Line Proteomics	1.0	2.5788
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	1.91129
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97569
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24833
NR4A1_01_174	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.74333
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	GTEx Tissue Gene Expression Profiles	-1.0	-1.29951
GTEX-WFG8-0126-SM-4LVMH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.208
hsa-miR-1248	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23694
kidney	HPA Tissue Gene Expression Profiles	1.0	1.29439
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5559
cho/dhfr	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
SHANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33726
primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.554876
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871278
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64704925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60538
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.933
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_311_KO_CARM1_SRP279319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57242
Multiple mitochondrial dysfunctions syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
ALDH2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13938
Perturb_9841_KD_KDM6A_SRP254623	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.2941
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.751
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68148
GTEX-OIZI-0226-SM-2XCEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06617
MRPS10	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Perturb_71_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.3589
chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.85437
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.6697
GSE210655_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75768
GSE160373_1_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046684
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89894
Perturb_7327_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.53826
ETP-46464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16453
intracellular organelle lumen	GO Cellular Component Annotations 2015	1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
SNU5	CCLE Cell Line Gene CNV Profiles	1.0	2.16956
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MT-ATP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65406
leukemic	GeneRIF Biological Term Annotations	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6445_KO_YAP_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.39715
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.03266
647-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U3ZH-1426-SM-4DXSR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82448
19636063-TableS6	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963001
PKBalpha_KO_GDS1784_193_mouse_Embryonic fibroblasts (MEFs) - 0 hour	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Ankle joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.77831
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852905
SDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04281
Perturb_7852_KD_XAB2_SRP193107	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.4117
Bloodstream form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Acute Myeloid Leukemia_LAML_TCGA-AB-2838-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_312_KD_XBP1_SRP279319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.00764
GSE226408_2_v_3_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stigma papilla	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.936
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
K562_Ellagic acid_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166422
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87167435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02968
Perturb_8488_KO_GOLPH3_SRP401813	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.671047
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
PAM complex, Tim23 associated import motor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.222
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26431
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12046
Perturb_7534_KO_HDLBP_SRP255633	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.8362
Cell septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.769
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.951197
NFIC	ENCODE Transcription Factor Targets	1.0	null
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93851
JF-84-QZ64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213685
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949044
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244203
hsa-miR-3916	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Athos	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01651
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Acute lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10099_KD_HNRNPU_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.08004
Hydrogenosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.685
Metabolism of proteins	Reactome Pathways 2014	1.0	null
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.28131
MRPS9	Pathway Commons Protein-Protein Interactions	1.0	null
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9892
membrane-enclosed lumen	GO Cellular Component Annotations 2015	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K88812218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63213
NCIH1944_LUNG	CCLE Cell Line Proteomics	1.0	2.65249
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35265
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
LYL1	ChEA Transcription Factor Targets	1.0	null
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.199
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.90601
fat_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.87009
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMLHE	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic lethality between implantation and placentation, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.68
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240016
Null cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
C10orf2	Pathway Commons Protein-Protein Interactions	1.0	null
establishment of protein localization to mitochondrion	GO Biological Process Annotations 2015	1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MLL1/2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5630_KD_EWSFLI1_SRP340258	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.40331
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.83
SBK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31374
PMC8047442-EMBJ-40-e105492-s003.xlsx-MR_plot_analysis-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06232
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.277
GTEX-TKQ2-0226-SM-4DM6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68602
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0903
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.744027
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72467884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12015
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23147
BRD-K37900095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14932
BRD-K78647367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07988
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14187_KD_RUNX1_SRP159178	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.99159
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26001
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15161
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CAL29	CCLE Cell Line Gene CNV Profiles	1.0	2.11497
THNSL1	Pathway Commons Protein-Protein Interactions	1.0	null
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.596
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6526899__F3	PFOCR Pathway Figure Associations 2024	1.0	null
TRUB2	Pathway Commons Protein-Protein Interactions	1.0	null
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22493
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16716
Perturb_11927_KD_SMARCB1_SRP127642	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.76171
LIVF001-027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94583
DBT	Pathway Commons Protein-Protein Interactions	1.0	null
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55095
peptidase	GeneRIF Biological Term Annotations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.928225
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00448
BRD-K89199943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23217
FTC133	CCLE Cell Line Gene CNV Profiles	1.0	1.37663
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13873
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9176
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37969
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.900551
membrane-enclosed lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.059931
18757322-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GRHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5003
Perturb_5563_KO_KDM4C_SRP375293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.40466
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09676
Perturb_7911_KO_LIN52_SRP367036	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.29767
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76328
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01823
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34925
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1808
Perturb_13653_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.08293
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.087
toxin-antitoxin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.176
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
NDUFS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12351_KD_DDX3X_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.42728
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SOX2_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
mitochondrial protein processing	GO Biological Process Annotations 2023	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05815
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2022
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.0929
5677_NIPBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582538
OV7	Achilles Cell Line Gene Essentiality Profiles	1.0	1.55988
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247084,GSE247087_0_v_1_cdyl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UH-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.34221
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	1.48886
Perturb_2327_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.7771
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3201
15902281-TableS1d	GeneSigDB Published Gene Signatures	1.0	null
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16258
Plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
DLD	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QLQ7-0826-SM-447B3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955767
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
SRSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91464
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6261
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0755
GTEX-S4Q7-0226-SM-4AD5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08398
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PUS1	Pathway Commons Protein-Protein Interactions	1.0	null
16207381-Table1Sb	GeneSigDB Published Gene Signatures	1.0	null
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04732
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.840302
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838924
Perturb_10095_KD_AGO2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.7255
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55643
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08864
SCC-25	COSMIC Cell Line Gene Mutation Profiles	1.0	null
T-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249078
Juxtaglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.04
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7841
MRPL47	Pathway Commons Protein-Protein Interactions	1.0	null
Plant tumor tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.621
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33692
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.080849
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0326-SM-32QOK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06564
Multiple mitochondrial dysfunctions syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.402
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59449
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23107
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4763-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SMC3	ENCODE Transcription Factor Targets	1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7037
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPL2	Pathway Commons Protein-Protein Interactions	1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558142
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12824
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58397
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32543
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2307
Perturb_14288_KD_ALKBH5_SRP272155	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.27326
EFM-19	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69225
amygdalohippocampal transition zone, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15043
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03414
BRD-K85901675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24934
PMC9314667-Table_1.xlsx-Regulons-SOX11_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45999
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90858591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36882
HCFC1	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47149
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.02831
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.875502
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2576_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.62525
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7434
GTEX-PLZ6-0226-SM-3P61I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43489
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14500_KD_RUNX1_SRP265128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.24738
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PKP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40472
GSE183271_5_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67235
Perturb_14202_KD_KLF5_ERP117894	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.24402
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09198
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7953
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.8276
HCC2279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6246
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
rectum_8c	HPA Tissue Sample Gene Expression Profiles	1.0	0.82854
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02345
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13020_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FLOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07329
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11192
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542509
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.0967
RXRA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Autosomal recessive cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.559
BRD-K22093970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5132
FOSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23954
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77318
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09327
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46045
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43643
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
TNNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38371
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.09
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65445351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80207
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1124
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMPCB-related mitochondrial disorder	ClinVar Gene-Phenotype Associations 2025	1.0	null
D283MED	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69375
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUDHL8	CCLE Cell Line Gene Expression Profiles	1.0	1.69422
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6480_PMPCB_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.685033
BRD-K24499562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38809
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0977
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3094
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5518
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.3468
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040397
GTEX-NL4W-0011-R2a-SM-2I5GV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3774
HARS2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K74933734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69199
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0817
Inflammation	CTD Gene-Disease Associations	1.0	1.2975
SUMO activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.446
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01214
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.85
some	GeneRIF Biological Term Annotations	1.0	null
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPK5-2026-SM-4JBIM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928857
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_8446_OE_PCK1_SRP155565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.51313
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.520903
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13014_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SARS-dORF6_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.51728
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286184
Perturb_8185_KD_DNAJC2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.1567
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.406
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.21668
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.965
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Natural killer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
Inflorescence stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
MDAMB453	CCLE Cell Line Gene Expression Profiles	-1.0	-2.53775
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
natural killer cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.56341
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47244
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.912
transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.086561
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19105
Perturb_9942_KD_NAA15_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.56882
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7074
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
AE-11-VB80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295721
hsa-miR-940	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217972
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB30-HNC	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6378
Perturb_6770_Mut_FOSL_SRP343264	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.62437
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
phospholipase C-activating angiotensin-activated signaling pathway	GO Biological Process Annotations 2025	1.0	null
GTEX-UTHO-2726-SM-4JBH9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831384
Increased Serum Lactate	DisGeNET Gene-Phenotype Associations	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.4491
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Renal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.038
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.933876
Juxtaglomerular apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.177
MRPL48	Pathway Commons Protein-Protein Interactions	1.0	null
SW48	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94139
pmpcb	GeneRIF Biological Term Annotations	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926253
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.914777
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09941
pink1	GeneRIF Biological Term Annotations	1.0	null
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10068
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-3.22203
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MR-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15157_KO_ZAP70_SRP192607	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.50989
hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K15876355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77297
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-30b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
umbilical cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5431-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle lumen	GO Cellular Component Annotations 2015	1.0	null
Perturb_8331_KD_METTl14_SRP167173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.5607
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66941670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61605
Dede	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827933
KO52	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24892
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2605
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08983
TRIM28	ChEA Transcription Factor Targets	1.0	null
Perturb_2337_KD_WBP11_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.54907
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03038
Perturb_2318_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.77372
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37015
CTCF_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
FOXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16971
NR2C2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0226-SM-4B65D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60025
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938512
iron-sulfur cluster transfer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.969
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R8a-SM-2I5GU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909871
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63477
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7296
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60644
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.199
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831109
MCCC2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3378
ACOT9	Pathway Commons Protein-Protein Interactions	1.0	null
SR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.77
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.86051
Perturb_409_KO_IRE1_SRP353826	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.69341
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MRPL22	Pathway Commons Protein-Protein Interactions	1.0	null
MRPL13	Pathway Commons Protein-Protein Interactions	1.0	null
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3152-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.729641
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic lethality between implantation and somite formation, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C32	CCLE Cell Line Gene Expression Profiles	1.0	1.45149
Perturb_2325_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.80005
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13844473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06697
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927515
A2058_SKIN	CCLE Cell Line Proteomics	1.0	2.20055
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S01_LF_C1_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537838
Friedreich ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.743
BRD-K74908937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25846
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.98099
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039928
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.3472
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
Muscle Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14197
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286395
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6422987-Table_1.XLSX-Sheet1-NME2_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6442_KO_RHO_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.10366
External gill	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
HOP-92	GDSC Cell Line Gene Expression Profiles	1.0	1.64035
Brain Lower Grade Glioma_LGG_TCGA-DU-6410-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.6873
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00105
parasitic helminthiasis infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.544705
Perturb_13936_KD_TTC8_SRP345436	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6274_KD_HOXCAS3_SRP158772	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.76118
BRD-K31852848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09748
BACH1	ENCODE Transcription Factor Targets	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
import	GeneRIF Biological Term Annotations	1.0	null
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26891
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1356
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0658
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49169
Perturb_2326_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.97271
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72753
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448906
CTCF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
free-living state	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
COX4I1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14021_OE_MIR722_SRP185837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K47283018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24374
BRD-K14081852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0009
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8556
arginase2	GeneRIF Biological Term Annotations	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87316858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09935
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985275
BRD-K97682096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41896
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045161
Perturb_9957_KD_SNRNP200_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.47121
Perturb_440_KD_PRMT5_SRP073189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.82025
LAMA84	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05642
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-1526-SM-3NB1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867633
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.3366
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.91153
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.889357
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GAK	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.26413
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial ATP-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.835
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904676
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-04-JM33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251104
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.919239
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OAW28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74671
C1QBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40017
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71919612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71634
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.544938
BRD-K76426411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12853
SUDHL10	CCLE Cell Line Gene Expression Profiles	1.0	2.20453
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.9224
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.909727
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.853147
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32509
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63089
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02094
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
icSARS CoV_48Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.57408
hsa-miR-3925-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
MRPL20	Pathway Commons Protein-Protein Interactions	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27353
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.1858
C32	CCLE Cell Line Gene CNV Profiles	1.0	2.03889
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3514_KD_RNPS1_ERP130704	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.1326
Hairy root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.315
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
metalloendopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.31143
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q1-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.39131
DNAJC19	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE450	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.14987
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14437
GTEX-Q734-0126-SM-48U1E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34408
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56072
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324846
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.26083
Charcot-Marie-Tooth disease type 2A2B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8367_KD_IGF2BP1_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.55622
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69481
SCC-25	GDSC Cell Line Gene Expression Profiles	-1.0	-2.74445
Combined oxidative phosphorylation deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44995
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-ENSEMBL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9282
MHH-PREB-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.55463
BRD-K07939054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22135
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1518
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL49	Pathway Commons Protein-Protein Interactions	1.0	null
LNCaP cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.00358
Perturb_449_KO_RPA_SRP158719	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.49977
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33312
NME4	Pathway Commons Protein-Protein Interactions	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05977
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40733000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13829
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.17594
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6295
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19684
QGP1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01447
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_1-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235550_1_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.19117
KB-72-ID36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211832
BRD-K89532826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77723
RARS2	Pathway Commons Protein-Protein Interactions	1.0	null
Pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.51
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_13655_KO_TAPR1_SRP291201	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36522
GSE110178_4_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363985
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Sessile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84874502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19966
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885418
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06277
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8162
BRD-K64763786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53524
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11153
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5723
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38547
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.0037
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9276
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U2-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.73623
Perturb_11933_KD_RNF5_SRP276909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.6641
FOXA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55043
BRD-K06519744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75293
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NACC1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	1.0	null
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362613
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GCIY	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.20543
BRD-K44956383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85299
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911215
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3725
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.82735
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.09549
BRD-K77940693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01393
BRD-K03067757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06849
BRD-A79248021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17437
Barth syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.990141
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
5637	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DAP3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17185909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42035
BRD-K47874568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09938
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-325	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Perturb_3532_KD_PTBP1_SRP310663	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.10649
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863914
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96596828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23015
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07172
Spinocerebellar ataxia type 28	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
Perturb_7665_KO_SNORD45C_SRP257547	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.05757
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.0867
Perturb_9677_KD_PIAS1_SRP295152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.62503
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.447
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419176
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A06149038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08689
Hereditary spastic paraplegia 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
BRD-K05777604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52853
hsa-miR-30d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.954876
RMGI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71979
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50906
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960122
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.28
WA-03-IF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26296
CUX1	ChEA Transcription Factor Targets	1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A51W-01A-21R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3512
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494775
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1052
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50324
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.193
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SFXN1	Pathway Commons Protein-Protein Interactions	1.0	null
Leukemia cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
substantia innominata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.955855
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24249
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EVSA-T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.78473
Malignant Squamous Cell Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Perturb_630_KO_HOXD3_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.52501
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08081
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein transport	GO Biological Process Annotations 2015	1.0	null
SARS-CoV_24Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.416
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NDUFS2	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5052
nuc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.062
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-VT-A80J-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Charcot-Marie-Tooth disease type 4A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
Lung squamous cell carcinoma_LUSC_TCGA-92-8063-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPS31	Pathway Commons Protein-Protein Interactions	1.0	null
OCUB-M	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69717
Mastigoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.337
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR2F2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07034
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48535
RTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05201
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7432
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3348
Rectus femoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
GSE252988_0_v_1_lefamulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPS14	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058576
FOXA2	ENCODE Transcription Factor Targets	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37893
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49588
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-2052	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX3-22085726-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2795-01A-02R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D-423MG	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.80147
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3262
tylosin-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15243
bsg	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-1976	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Perturb_467_KD_ADAR1/ADAR2_SRP253895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.5873
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-30e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.967724
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-340	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
infection	GAD High Level Gene-Disease Associations	1.0	0.293278
Perturb_9108_KD_STAT3_SRP363695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.27317
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ICT1	Pathway Commons Protein-Protein Interactions	1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary ciliary dyskinesia 27	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.297
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14014
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE70883,GSE71179_0_v_1_pbx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MALSU1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24541
Developmental Regression	DisGeNET Gene-Disease Associations	1.0	null
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0373
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.4125
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.829043
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7139
RAD21_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5016-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84688
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nuclear pore outer ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.707
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7143
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37046
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PL-21	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.5381
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988013
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95251122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46707
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59507746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48519
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4587
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.433012
MRPS24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26867
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51463
LOUCY	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.15378
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71254
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPUSD4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NQ-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83054
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6962
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2437_KD_ZNF581_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.41752
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8618
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Combined oxidative phosphorylation deficiency 31	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.088
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052109
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0274
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96281
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86678
BRD-K09131889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01105
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.43544
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19247
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.891447
TRIM24_knockout_299_GSE19675	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.87266
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K23870105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06011
BRD-K47217000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62764
MRPS7	Pathway Commons Protein-Protein Interactions	1.0	null
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.626
TIMM44	Pathway Commons Protein-Protein Interactions	1.0	null
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
prenatal lethality	MPO Gene-Phenotype Associations	1.0	null
NIPSNAP1	Pathway Commons Protein-Protein Interactions	1.0	null
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887918
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Las1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.092
protein localization to organelle	GO Biological Process Annotations 2015	1.0	null
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.996742
MRPL55	Pathway Commons Protein-Protein Interactions	1.0	null
Coronavirus disease - COVID-19	KEGG Pathways 2026	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2974
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285711
RA-49-ZB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279155
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2362
antigens	GeneRIF Biological Term Annotations	1.0	null
15520196-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7453
BRD-K11667893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18515
BRD-K28814368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11124
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
ERLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30936
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAL1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2647
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4055
BRD-K95588139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24293
BRD-K55946794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54575
BRD-K16330310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24339
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leaf disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
Perturb_16503_KD_NEUROD1_SRP325888	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.49237
Inner ear disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.83
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61732
Spondylometaphyseal dysplasia Megarbane-Dagher-Melike type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.267
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4997
organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.065088
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40098
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.3795
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.29464
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.485156
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.848827
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.38628
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.858636
Ebolavirus(EBOV)_6day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.56205
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56276074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17008
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A6-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
K562_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178629
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43869
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043796
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.229716
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7723
SAS	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.60429
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.55638
Harel-Yoon syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
Theca folliculi	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
BRD-K71460915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26547
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.859492
lymphoblastoid cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.15759
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828843
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lhx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8656
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gilles de la Tourette syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
SW626	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.64211
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Perturb_6437_KD_HDAC1_SRP327853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.8255
RAD21_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979566
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DE-01A-22R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99978187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11859
GTEX-U4B1-0126-SM-4DXSN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11629
BRD-K46820725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52682
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23213
GTEX-UJMC-1326-SM-4IHLS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95864
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
PPARG	ChEA Transcription Factor Targets	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.94083
OE21	CCLE Cell Line Gene CNV Profiles	1.0	2.8695
BRD-K13681383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06962
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.533842
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98921
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834142
SALL4-18804426_ESC-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7337
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9972_KD_BCLAF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.71036
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	1.79903
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250249
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.758
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14611_KO_MTAP_SRP186070	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.09378
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.7531
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
HCC1419	CCLE Cell Line Gene Expression Profiles	-1.0	-2.18022
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203069
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1624
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08302
Perturb_13018_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Mitochondrial processing peptidase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15876
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91903
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_6618_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HB-01-ZU75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297784
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Peptidase M16, C-terminal domain	InterPro Predicted Protein Domain Annotations	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.35435
Perturb_6839_KO_EIF5A_SRP199981	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.0549
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.80841
Perturb_625_KD_IGF2BP3_SRP068523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.67368
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925931
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.98813
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951653
BRD-K99416393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11461
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K21747676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07083
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931156
L33	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01211
BRD-K53401077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29206
Perturb_10138_KO_PRPF40B_SRP197235	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.63614
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65377
angiotensin receptor activity	GO Molecular Function Annotations 2025	1.0	null
Perrault syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.92
Perturb_13370_KD_NR1D1_ERP118284	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.3583
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881724
CIA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.8442
protein localization to mitochondrion	GO Biological Process Annotations 2015	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9667_KO_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.13603
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YF-64-PQ11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211817
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	1.0	3.03724
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01545
embryonic lethality prior to organogenesis	IMPC Knockout Mouse Phenotypes	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
Perturb_8434_KD_CCT3_ERP124101	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.37158
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838922
hsa-miR-30c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Perturb_10093_KD_XRCC6_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.8394
single-organism localization	GO Biological Process Annotations 2015	1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.911366
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.527033
SET2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39062
NCIH1563	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49944
Exoskeleton	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.868
t69-brown-adipose_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-5.62855
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS834T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53294
MMAB	Pathway Commons Protein-Protein Interactions	1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04332
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.9254
CTCF_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TY-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16727544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19583
EFM19_BREAST	CCLE Cell Line Proteomics	1.0	3.10363
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.85123
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3536
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.813453
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349235
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.37979
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1905
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970459
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4507
CHP126	CCLE Cell Line Gene Expression Profiles	1.0	1.40415
Perturb_14150_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Chromosome 15q11.2 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
Renin-angiotensin system	KEGG Pathways 2026	1.0	null
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997248
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPS21	Pathway Commons Protein-Protein Interactions	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323123
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_1370_KD_IGF2BP1_SRP252209	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.44039
Perturb_7854_KD_CCNF/E2F7/E2F8_SRP212181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.7206
hsa-miR-299-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01818
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61H-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84606053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24939
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.31897
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS26	Pathway Commons Protein-Protein Interactions	1.0	null
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.759131
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
C32	Achilles Cell Line Gene Essentiality Profiles	1.0	1.56585
FOXA1_OE_GDS4957_144_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SLC25A10	Pathway Commons Protein-Protein Interactions	1.0	null
Sensorineural hearing loss	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BICR16	CCLE Cell Line Gene CNV Profiles	1.0	1.50243
Lung Injury_Lung Tissue_GSE1541	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.98978
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162726
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.17507
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.594503
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.53163
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5493
hsa-miR-4677-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
ANTKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47012
SLC25A4	Pathway Commons Protein-Protein Interactions	1.0	null
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.38284
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.932642
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.979895
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZF-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054412
HSD17B10	Pathway Commons Protein-Protein Interactions	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spinocerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.621792
protein targeting to mitochondrion	GO Biological Process Annotations 2015	1.0	null
GSE159678_4_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.998679
Perturb_2301_KD_BRCA1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.05373
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1687
Perturb_8852_KD_SNHG15_SRP189766	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.08698
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.55638
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4784	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60422
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865746
Perturb_3654_KO_METAP1_SRP116953	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.70663
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.7954
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.0529
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00263
tc96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02286
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13192
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytochrome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.13156
hsa-miR-374a	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
fluorouracil_homo sapiens_gpl550_gds845	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Infertility, Female	CTD Gene-Disease Associations	1.0	1.1529
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Meprednisone_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014163
CingulateCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07378
pink1parkin	GeneRIF Biological Term Annotations	1.0	null
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214475
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spastic ataxia 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00911
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843542
SHKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12462
UQCRC1	Pathway Commons Protein-Protein Interactions	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
processing	GeneRIF Biological Term Annotations	1.0	null
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6073
MutS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.709
SLC25A33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48254
Subfornical organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
GSK3B_knockdown_202_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.54822
Perturb_15462_KD_FOXA1_SRP353748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.02577
Replication inhibiting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
vitamin c_mus musculus_gpl1261_gse37676	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-IE-A4EI-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08311
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1574
CHD1	ENCODE Transcription Factor Targets	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.953732
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-dORF6_12Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.5057
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3949
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345682
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396586
BRD-K70357895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0631
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29252
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9157
Prostate adenocarcinoma_PRAD_TCGA-HC-A4ZV-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1114
Perturb_9934_KD_AKAP8L_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.59846
BRD-K32751688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32741
hsa-miR-1207-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ZNF699	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25974
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5324
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35468
BRD-K41809257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23081
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inflorescence apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5018
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.5576
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.363
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1072
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5249
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.6001
Perturb_2332_KD_SNRPE_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.44762
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1006
RAD21_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32133
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.829278
GTEX-SNOS-0526-SM-4DM54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16239
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.63017
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18711
Cytochrome b6f complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
RARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47825
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238108
Perturb_2395_KD_TRIM28_SRP308699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149124,GSE149128_3_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59611
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pharyngeal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
BRD-K59188100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76587
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular protein localization	GO Biological Process Annotations 2015	1.0	null
BRD-K73858940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19783
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7582_KO_MBD5_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.4428
Perturb_2889_KO_Mcrip2_SRP302058	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.0492
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.614
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.632
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37998
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Perturb_17530_KO_TET1_SRP150212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.28023
KRAP_Deficiency_GDS3528_564_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE264010_0_v_1_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z3-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7179_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.81838
PMC7906601-elife-62470-supp4.xlsx-Table_S7_MS_and_siRNA_KD-Supplementary_File_4_Summary_of_HIV-1_splice_variant_interactome_MS_data_and_siRNA_KD_expression_changes_data_Related_to_Figures_2_and_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42204
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6494
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
daudi	HPA Cell Line Gene Expression Profiles	1.0	1.21927
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63394
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.799538
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LYL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4452	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE92364_1_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TGBC1TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.232
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C32	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4725-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.1086
BRD-K68617666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72758
BT-483	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07139
BRD-K96258717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27702
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86879
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1143	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4003
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A03764094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21214
CTCF_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21355275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15404
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26393435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06806
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36787
GTEX-V955-0126-SM-4JBH5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45973
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-2909	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.23527
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1693_LUNG	CCLE Cell Line Proteomics	1.0	4.68652
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Protein localization	Reactome Pathways 2024	1.0	null
Perturb_8283_KD_BCLAF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.49835
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20043
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34256
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426208
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
establishment of protein localization to organelle	GO Biological Process Annotations 2015	1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1_OE_GDS4957_10_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11776
preweaning lethality	MPO Gene-Phenotype Associations	1.0	null
BRD-K75207324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15229
BRD-K05181466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07309
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AARS2	Pathway Commons Protein-Protein Interactions	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.666635
SOX2-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250165
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218245
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36316
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347501
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2906
Perturb_7131_KD_SETD8_DRP009168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.85058
Perturb_7269_KO_ALKBH3_SRP064738	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.6867
MRPS17	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K64268886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12417
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.981102
BRD-K79318338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20082
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.953852
MALME3M	CCLE Cell Line Gene CNV Profiles	1.0	1.56252
Perturb_9337_OE_FGFR1_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.57439
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10998
BRD-K14451397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28756
PPARD_KO_GDS4320_619_mouse_Pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92411
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-0.93695
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.889873
embryonic lethality prior to organogenesis	MPO Gene-Phenotype Associations	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
artery	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Rad17 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.161
JE-61-EQ70_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248858
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.1461
DPH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24653
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Plant cuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54067
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1713
CCNT2	ENCODE Transcription Factor Targets	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15272
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFS3	Pathway Commons Protein-Protein Interactions	1.0	null
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03619
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
rtg2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8051
ISG20L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62455
Perturb_8703_KD_AR_SRP010350	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.13099
H4K20me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.56262
BRD-K02747732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44716
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.498588
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.71819
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161143
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methyl-salicylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83986
Perturb_11949_KD_NRF2_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950951
Zona glomerulosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00162
MYBL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94712
BRD-K88960810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05407
BRD-K14534138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73507
ST486	CCLE Cell Line Gene Expression Profiles	1.0	1.63595
intracellular protein transport	GO Biological Process Annotations 2015	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46391
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.971027
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2176
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WYJK-1326-SM-3NB2T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02868
PMPCA	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25397
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.905391
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-0126-SM-3DB83	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923959
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2899
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62698
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.426
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88069191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09553
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SKCO1	CCLE Cell Line Gene Expression Profiles	1.0	1.6085
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_3766_KD_lincDUSP_SRP111736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.22526
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.152899
SARS-dORF6_72Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.96043
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.1973
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.877151
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3856
BRD-K97393725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06712
BRD-K80807286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59635
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.81567
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054596
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.993422
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.62541
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.985
Perturb_13518_KD_ILF2_SRP077068	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.88294
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277104
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05421
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41053
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.02536
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9884_KD_DDX47_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.7268
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ascites	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.242
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.009
Tongue muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MRPL27	Pathway Commons Protein-Protein Interactions	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9830_KD_USP7_SRP256243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.18838
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.581892
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1627
Perturb_9986_KD_U2AF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.38772
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46066
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856182
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09789
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.90035
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.37278
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hinge joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
WDR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75753
GTEX-U3ZN-0326-SM-3DB86	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883391
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7701_KD_Spt6_SRP132004	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.78375
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.58144
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.57125
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
early-onset Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17789
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFG7-0326-SM-3GILI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10239
DNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10598
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKT_UP_MTOR_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
ERBB4:ERBB2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
respiratory chain	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.364331
Nasopharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
GTEX-OHPM-2626-SM-33HC5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934002
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75431
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChaGo-K-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-147	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
SKOV3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74106
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1152
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900459
PMC2530868-gb-2008-9-7-r111-S5.xls-Inc_hgu133_AAG-AA-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
NR2C2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL9	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6855_KD_YTHDF1_SRP287222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.61237
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.35653
hsa-miR-374b	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Isl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.363
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76482408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52914
GSE147240_0_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93442068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22726
BRD-K10143126_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATAD3A	Pathway Commons Protein-Protein Interactions	1.0	null
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0533
hsa-miR-1273e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.901752
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
10358_ZNF436_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540471
GTEX-QDVJ-1126-SM-48U1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15847
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36657
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42105
microcystin RR	CTD Gene-Chemical Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A2-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96922
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272476
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873789
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12568
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-30-SX80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308228
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR2C2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
b16f0	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
JHOS2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43714
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrion	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.84054
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.960589
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54779
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04118
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82509605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42444
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K15997423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34233
succinate-CoA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.01
SP1	ENCODE Transcription Factor Targets	1.0	null
EP300-20729851-FORBRAIN-MIDBRAIN-LIMB-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.942498
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.4647
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256368
RASSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26712
BRD-K84060528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10068
BRD-K70854630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95952
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.545341
E2F1	ChEA Transcription Factor Targets	1.0	null
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.00924
Bacterial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.742
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2949-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200559
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913111
Entrectinib_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00726405
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.16797
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K67670670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08778
GSE158197_6_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.99779
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38856
BRD-K86004174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32566
BRD-K44828787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37443
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.732624
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QY-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Transport of small molecules	Reactome Pathways 2024	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K10704442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27749
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881446
cellular macromolecule localization	GO Biological Process Annotations 2015	1.0	null
BRD-K42385001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60815
CTCF	ChEA Transcription Factor Targets	1.0	null
Perturb_14606_OE_NUSAP1_SRP407652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.3496
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4466
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4911911-supp_055871.116_Supplemental_Table_S5.xlsx-tab2_FBF_and_yeast_PUF_shared-Human_ortholog_Ensembl_IDs_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.482768
sulindac sulfide-308	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42679315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42837
BRD-K94962552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44417
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.359695
JB-89-SI60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTPBP10	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pitcher	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1073
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.30329
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5834
NCI-H1755	COSMIC Cell Line Gene Mutation Profiles	1.0	null
7524_RPS3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.716289
Calu-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.865
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0201
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23687
Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
complete embryonic lethality between implantation and placentation	MPO Gene-Phenotype Associations	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NOMO-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.06521
Perturb_13918_OE_PPARGC1A_SRP265351	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K30055322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25377
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7475
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62249
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7803
Sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82756
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS30	Pathway Commons Protein-Protein Interactions	1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	1.21668
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924859
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.8815
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sensorineural hearing loss	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.83
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7348
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.651
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-0326-SM-33HBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910627
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13618
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.752187
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PNPT1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291575
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6954
ATP5H	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67090705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33592
Perturb_7235_KD_CNOT1_SRP285534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.00534
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82376876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81558
FOS	ENCODE Transcription Factor Targets	1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.099
RAD21_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-1726-SM-4E3J7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999623
BRD-K21416096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01435
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7913_KO_ZNF335_SRP367036	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.66972
BRD-K39099034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09645
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2166
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.910128
MRPS27	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39715006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07068
MDA-MB-361	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44333
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45058
Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8887
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74063
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02441
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.852
rock	GeneRIF Biological Term Annotations	1.0	null
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99745
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B6-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSF1_KD_GDS1733_753_human_HeLa cells - 4 Hour by siHSF1_1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
YME1L1	Pathway Commons Protein-Protein Interactions	1.0	null
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51923
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61019
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6827-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60850201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82163
Myopathy with extrapyramidal signs	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
BRD-K48102350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44557
EHMT2_KD_GDS4800_315_human_MDA-MB231	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2375
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.073
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.164089
18818702-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77864
Multiple mitochondrial dysfunctions syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58643762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51028
GTEX-QDVN-1226-SM-48TZ5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922587
Plant cell papilla	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.935
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Heart endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Mycoplasma pneumoniae pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7600_KO_LEF1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.77367
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05873
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74647
oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.083036
3809_HLA-C_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.716993
ND-36-VC68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265818
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2023
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62466453_NCGC00182388-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.6556
PMC3853418-1756-8935-6-34-S2.pdf-3-ZSCAN12_ZSCAN12	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926242
BRD-K85908443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50188
Perturb_9944_KD_RBM15_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.6904
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04045
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34642
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	2.02079
calcium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
Perturb_8197_KD_TRIM56_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.85774
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850588
PTCD3	Pathway Commons Protein-Protein Interactions	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
Finasteride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
MRPL50	Pathway Commons Protein-Protein Interactions	1.0	null
Multiple mitochondrial dysfunctions syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
PRDX4	Pathway Commons Protein-Protein Interactions	1.0	null
MRPL17	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nitric-oxide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962942
FOXP2	ENCODE Transcription Factor Targets	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203-2004(H5N1)_24Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.69808
nocodazole-621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.36719
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.6909
Mesocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.5
cc81	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7055
biological_process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3688-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NR2C2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040508
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195663_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.5092
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
Combined oxidative phosphorylation deficiency 19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.992
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847645
Perturb_2455_KD_ZNF213_SRP243455	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.45402
BRD-K10301055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19028
GSE114685_1_v_0_grin2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_10352_KO_AATF_SRP257744	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.17316
Perturb_443_KD_SBF2AS1_SRP116042	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.59513
GTEX-T5JC-2126-SM-32PMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26888
BET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08504
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
BRD-A96183603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05832
NSL complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.635
UQCRFS1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68333644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11455
MRPL32	Pathway Commons Protein-Protein Interactions	1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X5EB-2426-SM-4E3HX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10093
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UMUC3_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.09793
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33504
Bb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.156
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962982
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64838
MYO18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34277
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ercc1	GeneRIF Biological Term Annotations	1.0	null
BRD-K68060538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02633
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23054
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851959
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55127
FOXA1	ENCODE Transcription Factor Targets	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.9084
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33416
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7221
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-PW2O-0226-SM-48TC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30064
TRMT10C	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ES3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927236
Brain Lower Grade Glioma_LGG_TCGA-HT-7475-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A14803952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50938
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV44-0826-SM-2S1RG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847376
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FS-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_505_KD_WTAP_SRP039397	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47352
H3K27ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925494
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8050_KD_METTl14_SRP167173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.66739
Peptidase M16 domain	InterPro Predicted Protein Domain Annotations	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSCB	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14572_KO_EP300_SRP336466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.68849
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05753
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.0417
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909216
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265218
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.796
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504112
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
G protein-coupled receptor activity	GO Molecular Function Annotations 2025	1.0	null
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03888
RAD21_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A-19761587-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.31654
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24602
metalloendopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_2290_OE_TBX3_SRP184219	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.21952
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3864
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278302
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2321
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	286.885
Brain Lower Grade Glioma_LGG_TCGA-FG-A711-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37763427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51665
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	100.978
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32838
DJM-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51988
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593575
VDR	ChEA Transcription Factor Targets	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92049
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.576887
Schizophrenia_CNS - Brain - Cerebellum (MMHCC)_GSE4036	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.666
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14323
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	166.44
metalloendopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886219
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.911128
GSE163052,GSE163198_5_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
Perturb_8205_KD_PCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.62777
HNF4A-19761587-HUMAN INTESTINAL CELL LINE CACO-2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCC-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70646
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.2122
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.659
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87277021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04584
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891976
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
CEBPB_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926932
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.1593
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043892
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312415
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53017
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.30682
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146687_2_v_3_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.95
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BL70	CCLE Cell Line Gene Expression Profiles	1.0	1.64911
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906243
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01989
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12308
metabolic process	GO Biological Process Annotations 2015	1.0	null
JM1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.05248
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92972
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H1836	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.51641
CST complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
PDK3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03904
EFNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539688
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960154
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-A46Y-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
DPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05639
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23606
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.25861
BRD-K66821167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06089
TIMM17A	Pathway Commons Protein-Protein Interactions	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08521
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Failure To Thrive	DisGeNET Gene-Disease Associations	1.0	null
Perturb_2520_KD_JUN_SRP357624	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.42243
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13271
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6391
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40665
Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GLDC	Pathway Commons Protein-Protein Interactions	1.0	null
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568691
GTEX-TSE9-0326-SM-3DB82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08463
Vastus lateralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9531
Acute Myeloid Leukemia_LAML_TCGA-AB-2915-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2316_KD_PRPF31_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.12264
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00228
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31015
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pro-b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.176978
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27953
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930695
ChIP_NANOG_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RF-48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.92437
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.81506
WHSC1	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.7508
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5045
Division septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.752
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.4003
Perturb_13855_KD_IGF2BP1_SRP284043	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.4332
Spondylometaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
cellular localization	GO Biological Process Annotations 2015	1.0	null
U251	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1596
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39501
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50831
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2554_KD_ZFX/ZNF711_SRP115395	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.38285
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-655	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.8124
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051895
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272518
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280767
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.67517
Perturb_13958_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.63164
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3768
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.8077
MAPK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11272
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49438
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14963
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0479
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.32941
embryonic lethality prior to tooth bud stage	MPO Gene-Phenotype Associations	1.0	null
OE33	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
EPLC-272H	GDSC Cell Line Gene Expression Profiles	1.0	2.77701
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882779
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Optic atrophy 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.447
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F5-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.3742
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03856
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3752
Perturb_9982_KD_SF3B4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.58369
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869656
PMC8482521-mmc13.xlsx-Phosphosites_12_hr_48_hr_MLR-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1395	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
cell property	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089215
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9943_KD_PUS1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.7505
Perturb_327_KD_MEX3A_SRP347450	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487614
Brain Lower Grade Glioma_LGG_TCGA-TM-A84B-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LS-180	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.90202
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99271
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043085
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55095
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6195
BRD-K79199168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47587
blood vessel	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_4383_KO_PRMT5_SRP149386	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.4629
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14072
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0277
BRD-K91085913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57715
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08682
hsa-miR-654-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.0667
Cell plate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02315086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87882
Root pericycle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211314
PMC5029704-oncotarget-07-24326-s006.xlsx-Sheet1-Genes_that_are_downregulated_in_low_TET1_compared_to_high_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
SNU466	CCLE Cell Line Gene CNV Profiles	1.0	1.75167
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.25953
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cyclosporine_homo sapiens_gpl570_gse15935	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-1726-SM-3TW8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69392
RPA2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44078665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11283
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.8995
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539083
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7644
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arthrogryposis multiplex congenita-6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.613
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07853
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bae1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
Perturb_3947_KD_RNF6_SRP126561	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.72552
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900999
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Inner ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
Pulmonary microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3545
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3468-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26847
Nephronophthisis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
GSE164874_5_v_1_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
phospholipase C-activating G protein-coupled receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494798
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.827028
BRD-K52634604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74384
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5665
FXN	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QXCU-0326-SM-2TC63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957864
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712143
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K34817515_Fluocinolone acetonide_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7532
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-617	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Hereditary spastic paraplegia 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
cd40activated	GeneRIF Biological Term Annotations	1.0	null
BRD-K91399333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9862
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.429
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054655
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058925
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23728544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56746
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.0766
POU5F1-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TQ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
CECR5	Pathway Commons Protein-Protein Interactions	1.0	null
VARS2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K71604365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17149
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.713
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.83
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A430-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37183
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTNNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30397
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8224-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
zinc acetate_homo sapiens_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
SKCO1	CCLE Cell Line Gene CNV Profiles	1.0	1.75506
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.899356
Left ventricular noncompaction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
FBL	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
angiotensin-activated signaling pathway	GO Biological Process Annotations 2025	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8359_KD_HNF4a_SRP365071	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.50017
resveratrol-662	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ACAD9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5244
Lung adenocarcinoma_LUAD_TCGA-91-8496-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05074020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81663
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39002
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.277
MCF7_BMS-911543_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141026
sirolimus_homo sapiens_gpl96_gds2494	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94775036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03044
ZNF44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00186
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-ddORF6_72Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.46941
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4758
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NACC1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC6739105-aau4139_Table_S5.xlsx-CMC-NR1H2_NR1H2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1568_LUNG	CCLE Cell Line Proteomics	1.0	2.13653
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.46385
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11242
AASS	Pathway Commons Protein-Protein Interactions	1.0	null
INCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10257
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29285
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.864414
MOLM-13	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.58542
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925329
BRD-K30172718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08447
GSE221327_1_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Large granular lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
EPLC-272H	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
vs86	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7336_KD_SUGP1_SRP286876	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.09717
Charcot-Marie-Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BRD-K72843176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09654
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.742
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.734
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1429
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31738
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9348
BRD-K65891102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44828
CRCGN016_MCF10A.WT.HP_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03372
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1572
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8513
TIMM17B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22236
BRD-K18515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26229
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7507
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.60149
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24718
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28276275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37005
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-NI-A4U2-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AGK	Pathway Commons Protein-Protein Interactions	1.0	null
Hmgn1_KO_GDS5010_406_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hsa-miR-214	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.911704
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_13662_KD_E2F1_SRP225180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.5724
CRCGN015_MCF10A.WT.HP_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46078
ventral anterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849095
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2638
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.486326
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3611	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307422
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20451
BRD-K38853406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19423
BRD-K74968522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20618
NANOG-21062744-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0686
L-cysteine desulfurase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.043
LMBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05135
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.885736
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTB-1	GDSC Cell Line Gene Expression Profiles	1.0	2.27658
mitochondrial matrix	GO Cellular Component Annotations 2025	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.1133
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.83944
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SLC25A13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.004057
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POU5F1-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hypomyelinating leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0827
hsa-miR-504	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
hsa-miR-4330	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
AGS	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.00508
hsa-miR-3622b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.639658
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73505
EBC1	CCLE Cell Line Gene CNV Profiles	1.0	2.3736
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02207
Perturb_2717_KO_TET1_SRP110516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.45639
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2329
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
Cerebellar Atrophy	DisGeNET Gene-Disease Associations	1.0	null
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36531
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905089
Peptidase M16, zinc-binding site	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K74568359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1269
SRI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41522
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347344
nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.087428
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CSTB_KO_GSE47516_18_mouse_brain (P7 cerebellum, P30 cerebellum, cerebellar granule cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26657
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97876
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37458
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829417
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3264
Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCV_8week-No IFN-a_None_GSE37715	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.75078
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5638
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
OVCAR8	CCLE Cell Line Gene CNV Profiles	-1.0	-2.23694
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4584
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10607
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31051
x63ag8.653	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
Blood cancer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
BRD-K10241968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21014
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MTG1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPL14	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246626
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.939189
BRD-K21167361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83408
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05938
PUSL1	Pathway Commons Protein-Protein Interactions	1.0	null
Myeloid Leukemia	DisGeNET Gene-Disease Associations	1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4401
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05332
MAZ	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_7614_KO_LARP1/LARP1B_SRP201361	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.41093
TCCSUP	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TCF12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.904107
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7247-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19436
ZNF143	ENCODE Transcription Factor Targets	1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0379
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24361
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.426
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6306
localization	GO Biological Process Annotations 2015	1.0	null
MCF7	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.49786
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.533058
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.302
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87651
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-12	GDSC Cell Line Gene Expression Profiles	1.0	1.48275
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16965
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11201
ChIP_NACC1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
Brain Lower Grade Glioma_LGG_TCGA-HT-7860-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7948
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27985
BRD-K39913853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24671
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NANOG-21062744-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14863829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69879
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LB996-RCC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EB-97-AV17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267201
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.21654
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48103
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38151
Endocuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6271
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77894681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16538
ADCK3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K35001076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07656
SH3BGRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17209
estradiol_homo sapiens_gpl6947_gse27375	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09778
OVCAR3	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.851274
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF347	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17544
skbr3	HPA Cell Line Gene Expression Profiles	1.0	0.844617
H3K36me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K00537235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30959
ChIP_CNOT3_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hmmrrhamm	GeneRIF Biological Term Annotations	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846348
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35756
PMC11286465-DataSheet1.PDF-8-FOXO3_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FARS2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE237040_6_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919951
GSE147240_0_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-200c	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.83
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_PRDM14_21183938	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Cco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
OVCAR4	CCLE Cell Line Gene CNV Profiles	1.0	1.76469
BRD-K51278788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01485
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7851_KD_XAB2_SRP193107	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.4974
BRD-K52391588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-6.25452
Biceps brachii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
BRD-K78574327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24644
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840655
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46573
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.049
NB69	GDSC Cell Line Gene Expression Profiles	1.0	1.8555
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
basomedial nucleus (accessory basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36095
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07534805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09011
Brain Lower Grade Glioma_LGG_TCGA-P5-A733-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.840036
Multiple mitochondrial dysfunctions syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94088690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24533
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0779
CPT2	Pathway Commons Protein-Protein Interactions	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52414
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904584
BRD-K56650430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10367
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72259
Arteriosclerosis	CTD Gene-Disease Associations	1.0	1.02447
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.702569
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29232
LDHD	Pathway Commons Protein-Protein Interactions	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GRPEL2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312132
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43242
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878302
TIMM23	Pathway Commons Protein-Protein Interactions	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.35101
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISCA1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046559
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9246
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL54	Pathway Commons Protein-Protein Interactions	1.0	null
Leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26663
Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4771	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.22339
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
3-methylglutaconic aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
Perturb_7853_KD_CCNF_SRP212181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.03633
CORL47_LUNG	CCLE Cell Line Proteomics	1.0	2.18484
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20124
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846348
GSE165647_5_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2374
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71102
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.892
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78384
Combined oxidative phosphorylation deficiency 52	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.898
Perturb_9899_KD_EIF3G_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.08153
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.1509
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7652
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15015
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.69687
GTEX-S341-0126-SM-4AD64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03958
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.419242
Perturb_7583_KO_MBD6_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.3947
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339081
GSE199543,GSE239447_0_v_6_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3BM-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226259_0_v_1_scd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.193
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25633
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890695
hsa-miR-4716-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Subcortical maternal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.798
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4423-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.983639
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61484
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4273
RBFA	Pathway Commons Protein-Protein Interactions	1.0	null
RS411	Achilles Cell Line Gene Essentiality Profiles	1.0	1.0119
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.49601
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.07851
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35594
Perturb_7136_KD_SETD8_DRP009168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.48595
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16689
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Weibel-Palade body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
BRD-K22683888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72963
Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3467	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.7925
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
BRD-K70289438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04224
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
Endopeptidase Clp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051502
BRD-K12260863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21179
Charcot-Marie-Tooth disease X-linked recessive 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.9
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.423
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATM_knockdown_18_GDS1852	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77423
C2CD4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02011
BRD-K61733751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53486
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.893537
BRD-K15341710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74476
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9899
KMS12BM	CCLE Cell Line Gene Expression Profiles	1.0	1.54564
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246431
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29611
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
even	GeneRIF Biological Term Annotations	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_14-Supplementary_Table_14_ETV6-activated_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3619-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A-Netherlands-602-2009(H1N1)_30Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.67386
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-Duck_gene_name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
lung	HPA Tissue Gene Expression Profiles	-1.0	-0.833141
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.887851
OVCA-429 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9228
TINAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3492
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21402
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12527
IRS1_KO_GDS1219_303_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886522
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0117
BRD-K37872081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30758
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17095
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TEAD2_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998666
ChIP_POU5F1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
DLD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065657
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.986487
colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.623043
BRD-K39435284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53966
BRD-K97562463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52196
BRD-K32916996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19016
macromolecule localization	GO Biological Process Annotations 2015	1.0	null
NSUN4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MTREX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03829
OC-71-BZ81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208845
Type IV pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
PMC12335956-BNEO_NEO-2024-000529-mmc1.xlsx-4_chr7essentials_published-THP1_Wang_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.58639
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28287
Ray floret	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0724
Perturb_3262_KO_VHL_SRP337931	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.53431
PTK7_knockdown_185_GSE50138	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.68468
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58281
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03078
Perturb_12738_KD_TCF7L1_SRP094619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.41676
Perturb_7321_KD_METTL14_SRP064870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.7317
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228605
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7693-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4775	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
Eukaryotic translation initiation factor 2B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.68
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03203
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1535
hsa-miR-876-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SCC25	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57555
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRICKLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03796
ZEB1	ENCODE Transcription Factor Targets	1.0	null
NOTCH_INHIBITION_GDS2794_61_human_MOLT4 (T-cell acute lymphoblast leukemia) cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13815
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6998
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2443_KD_ZRF1_SRP119501	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.87754
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.4603
metallopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
MTIF2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.916916
metallopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846348
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.7435
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	0.906154
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07367
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09165
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26869
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229122
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12337_KD_TFEB_SRP226507	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.5073
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.8249
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3622a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8567
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.842359
GTEX-UPIC-1526-SM-4IHLU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09397
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07365255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25058
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PF-39-DY68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.711926
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314887
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06405
Lung adenocarcinoma_LUAD_TCGA-35-3615-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07668
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835742
Perturb_13373_KD_RPRD1B_SRP362755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.37773
ALDH1B1	Pathway Commons Protein-Protein Interactions	1.0	null
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02767
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.33404
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87H-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CNOT3-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9818
NGRN	Pathway Commons Protein-Protein Interactions	1.0	null
NFIA_Deficiency_GDS2775_639_mouse_Embryonic brains (at E18)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4626
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.815
NDUFS8	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74506898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37719
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
zinc acetate_homo sapiens_gpl570_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.639
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Combined oxidative phosphorylation deficiency 43	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.041
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ORC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00336074
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.00165
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	2.18389
aortic	GeneRIF Biological Term Annotations	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.0445
RPL29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88255
BRD-K11566857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15662
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEL4-2126-SM-447AE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881975
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21441
HN1	Pathway Commons Protein-Protein Interactions	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4267
LN428	CCLE Cell Line Gene Expression Profiles	1.0	1.93651
CAL-62	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.04755
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26774
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13199
lung_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.837776
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00953
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30206
PMC6044369-oncotarget-09-29162-s002.xlsx-TableS5A_MYC_target_functions-Unnamed_7_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03312699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13782
GTEX-VJWN-0126-SM-3GIK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04779
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.1403
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
Perturb_4904_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.27533
ARID3A	ENCODE Transcription Factor Targets	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444275
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846348
BRD-K46439376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0119
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281108
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35087
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86995
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.60497
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95937143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13958
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2527
pre-b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.642048
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434716
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.42513
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13832
BRD-K16686330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43409
Combined oxidative phosphorylation deficiency 29	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
friedreich ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.848716
placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
DOHH2	CCLE Cell Line Gene Expression Profiles	1.0	2.38628
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15235
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bacterial biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.52
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35527
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.881726
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-27	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.90035
protein targeting to mitochondrion	GO Biological Process Annotations 2025	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50365
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09652
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Rotavirus infection of children_Peripheral blood mononuclear cell_GSE2729	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.96133
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3688
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BF-26-MB27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206161
cisplatin_homo sapiens_gpl570_gse15372	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_2697_KO_ADIPOR1_SRP089784	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.37492
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	3.02592
etoposide_homo sapiens_gpl10558_gse33990	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLF1	ChEA Transcription Factor Targets	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0533
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K32506050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00681
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.254
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043126
Urease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.652
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22145
mitochondrial inner membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-Q2AG-0126-SM-33HBV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866121
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0252
Kdm1a_KD_GDS5055_274_mouse_3T3-L1 preadipocytes - 24h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-4666-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617072
TARS2	Pathway Commons Protein-Protein Interactions	1.0	null
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5297
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.896837
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A4FUK	CCLE Cell Line Gene Expression Profiles	1.0	1.34832
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mammary Neoplasms, Animal	CTD Gene-Disease Associations	1.0	1.08513
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83835
SARS-CoV_48Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.63386
MDAMB453	CCLE Cell Line Gene CNV Profiles	-1.0	-2.0315
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.47597
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16727
Fruit juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.883933
POLRMT	Pathway Commons Protein-Protein Interactions	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7106
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.72807
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
t64-ovaries_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.24609
Perturb_9938_KD_DKC1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.4934
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332209
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8384
oxldl	GeneRIF Biological Term Annotations	1.0	null
PMC8450498__F1	PFOCR Pathway Figure Associations 2024	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spasticity, Ctcae	DisGeNET Gene-Phenotype Associations	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894738
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59233
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.989849
MRPS18A	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS2	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_7192_OE_DIMT1_SRP267960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.50324
BRD-K78315404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00028
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.856535
NCI-H209	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.90783
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46912
Perturb_9955_KD_SF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.47773
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.7098
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32193
Perturb_9863_KO_MYB_SRP192629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.76893
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64972
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11089_Mut_Tak1/Ripk1_SRP256942	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.92295
monastrol-614	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.58438
pancreas	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.27292
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7387_KO_UPF3B_ERP130413	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.08209
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5049
RAD21_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS18B	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial calcium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45679
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944307
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1662
PPAR-Beta_DELETION_GDS4320_363_mouse_Pancreatic beta-cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K74300740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17812
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.7561
STAT1	ENCODE Transcription Factor Targets	1.0	null
NUGC2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52954
Brain Lower Grade Glioma_LGG_TCGA-HT-8104-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26237438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48015
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K99387963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64986
Lymphocytic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5784
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18641
AD-11-VE17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314226
786-O	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838922
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2063
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.897229
CDK8_knockdown_63_GSE19199	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.32521
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369621
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.932804
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7825356-8844261.f3.docx-84-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7301-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIMM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22942
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4652-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLDIP2	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial protein processing	GO Biological Process Annotations 2025	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.0546
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.940137
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62741
SUMO3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46551
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19759
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58174
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.55638
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6382
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CTCF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.13314
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242054
SCA1_Knock-in_GDS1756_232_mouse_Cerebellum tissue - 12 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K99116119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0449
Perturb_2331_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.49358
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-645	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K88746179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34272
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40868
DB-41-IH69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211724
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LYL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CA46	CCLE Cell Line Gene Expression Profiles	1.0	1.63554
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057781
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7096
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79502
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488674
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00574
GSE223609,GSE223610_0_v_2_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61045
Perturb_741_KD_KDM4A_SRP181840	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.05152
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69004
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-96-WX99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204103
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95672449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24413
BRD-K97128200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02381
DNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.83
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1144
mitochondrial transport	GO Biological Process Annotations 2015	1.0	null
Perturb_14758_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.99447
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
16715129-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-8322-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07295
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K32949071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11964
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5135
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8042-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6362
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940142
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.16104
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.0674
single-organism intracellular transport	GO Biological Process Annotations 2015	1.0	null
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981428
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ovarian theca-interstitial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.216
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28307
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.862437
TAF1	Pathway Commons Protein-Protein Interactions	1.0	null
Dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
Blastema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
MRPL51	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic lethality prior to organogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1143	GDSC Cell Line Gene Expression Profiles	-1.0	-1.77142
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.409
CEBPB_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212926
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46762
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1369
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E0-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Metalloenzyme, LuxS/M16 peptidase-like	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
GSE176008_0_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.1373
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
Perturb_10026_KD_TRIM56_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.65393
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.928
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OE33	CCLE Cell Line Gene CNV Profiles	1.0	1.94647
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73525
GATA3-21867929-CD8-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285989
BRD-K49635910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07512
Perturb_691_KD_PTPN6_SRP275597	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.14435
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36639
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923541
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.783976
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectaladenocarcinoma	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.07585
Nephrolithiasis_Kidney_GSE10162	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.99239
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.4364
Perturb_15178_KD_NR037661_SRP394097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.90194
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fetus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.86498
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9938
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63609
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
EP300	ChEA Transcription Factor Targets	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2964
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Diverticular disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.33979
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10352551-ACEL-22-e13861-s001.pdf-12-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC6526899__F3	PFOCR Pathway Figure Associations 2023	1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47445
SKN-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ERCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27261
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Generalized Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OAT	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7067-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10832
vascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04345
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PRDM14	ChEA Transcription Factor Targets	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07417
embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
837_BIRC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548097
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12347849-mmc1.pdf-22-ENSG00000178764_ZHX2	Rummagene Transcription Factor Associations 2026	1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.329
GTEX-UPIC-0226-SM-3GADO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965768
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	1.42467
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954604
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9142
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0217
Perturb_7248_KO_LEF1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.34049
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2530868-gb-2008-9-7-r111-S9.xls-AAG-AA-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49B-01A-31R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oil secretion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.135
BRD-K23166347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70257
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SC-72-YW56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249537
BRD-K15444511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68185
BRD-K54790089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3606
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2603
FOSL2	ENCODE Transcription Factor Targets	1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.47241
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891059
Brain Lower Grade Glioma_LGG_TCGA-DU-7013-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2564
EFM19	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.51522
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.03256
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_13859_KD_MYCN_ERP107244	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.55753
AF-12-IW93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328953
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954604
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.953
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3362
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544357
GTEX-PLZ5-0326-SM-3P614	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2591
hsa-miR-1251	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K15647573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09671
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
59M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38166
Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97939219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26001
Multiple Mitochondrial Dysfunctions Syndrome	DisGeNET Gene-Disease Associations	1.0	null
Perturb_3873_KD_OR10A5_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.36004
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6805
SUDHL4	CCLE Cell Line Gene Expression Profiles	1.0	1.83512
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95852
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042646
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.12219
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6016
A-Vietnam-1203-2004(H5N1)_7Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.76863
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.175466
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Macrolide transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.372
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04704273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34045
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64642
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61714
ER-23166858-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_11960_KD_RAD6B_SRP258673	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.95071
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38333
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
highlight	GeneRIF Biological Term Annotations	1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9191
DCTN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04243
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DLD1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.54004
BRD-K60936953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48262
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1262	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23243
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18881
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43771
GTEX-WYBS-0926-SM-3NM94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05168
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34509
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.906527
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913704
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391471
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.492
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30745
1-bromopropane	CTD Gene-Chemical Interactions	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
hsa-miR-513a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Brain Lower Grade Glioma_LGG_TCGA-P5-A731-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02283
Adrenocortical carcinoma_ACC_TCGA-OR-A5JL-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-BRCA2_393_TCF7_rep1_sorted_peak-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261944
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6441-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL60	Achilles Cell Line Gene Essentiality Profiles	1.0	1.40441
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1357
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
ChIP_POU5F1_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cataract 38	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.951
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.28104
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77805
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7328_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.28128
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
UMUC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76733
GTEX-XPVG-0526-SM-4B65N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00798
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10218
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5393
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09524
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47808
P31FUJ	CCLE Cell Line Gene Expression Profiles	1.0	1.34763
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42H-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7788
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41676
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.759
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3536
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.3794
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13826
Neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Perturb_10035_KD_PUM1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.79157
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02129
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7158_KD_circFAM120A_SRP259913	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.65005
MAFF	ENCODE Transcription Factor Targets	1.0	null
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.746
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_8275_KD_SF3A3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.91493
NDUFA13	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50986
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82842087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02213
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851921
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49678
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94378105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18829
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13063
STX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47195
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69608
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38524
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
CNOT3	ChEA Transcription Factor Targets	1.0	null
dg2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
BRD-K86463534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46157
CTCF_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAJI	CCLE Cell Line Gene Expression Profiles	1.0	1.41666
BRD-K52688277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35078
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
SUPT1	CCLE Cell Line Gene Expression Profiles	1.0	1.39551
BRD-K43126701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46088
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
cellular_component	GO Cellular Component Annotations 2015	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
NCI-H1915	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.00046
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24418
Sarcoma_SARC_TCGA-SI-A71O-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
42MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55315
SPI1	ENCODE Transcription Factor Targets	1.0	null
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29638
GLUD1	Pathway Commons Protein-Protein Interactions	1.0	null
umbilical cord blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Type VI protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39793
precentral gyrus, right, bank of the precentral sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.901688
TAF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4395-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TIMM21	Pathway Commons Protein-Protein Interactions	1.0	null
nephronophthisis-like nephropathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
Perturb_14156_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.4044
UWB1.289	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94053
PRDM14-21183938-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01609
BRD-K22093396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4063
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75083
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25855
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55086
BRD-K36523261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62427
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL18	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.3106
DNAJA3	Pathway Commons Protein-Protein Interactions	1.0	null
DAOY	CCLE Cell Line Gene CNV Profiles	1.0	1.47358
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00407
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43207
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05058
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68159
Perturb_10061_KD_CCAR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60478
Mitochondrial calcium ion transport	Reactome Pathways 2024	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35439
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58984
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.979385
SKMEL5	Achilles Cell Line Gene Essentiality Profiles	1.0	1.62226
MRPS23	Pathway Commons Protein-Protein Interactions	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3929
A-CA-04-2009(H1N1)_18hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58773
Perturb_8753_KD_ANLN_SRP083014	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.92198
Germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.983
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.725
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83097
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.904387
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mesoderm	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.85595
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461203
deafness-dystonia-optic neuronopathy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
GSE180951_6_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RERFLCSQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.53766
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5006
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-0826-SM-3P61H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847048
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48278
RKO	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.48281
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SALL4_18804426	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35789
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.962982
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
MRPL19	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65779
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.23505
GTEX-QV31-0626-SM-447C5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937862
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE88819_11_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229879
SLC25A12	Pathway Commons Protein-Protein Interactions	1.0	null
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36676
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.12444
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346766
Perturb_9107_KD_G6PD_SRP287480	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.79193
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.44205
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8528
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7013
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2885
SARS-dORF6_36Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.48699
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.835432
EPLC-272H	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.82024
Lymphoblastoid cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00358
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5473
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.307
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.341
RASA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22372
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911106
HNRNPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41982
excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.151
GTEX-W5X1-0526-SM-3GILH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826158
RNF125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36783
Perturb_10052_KD_RPS19_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.02239
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL41	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ECI1	Pathway Commons Protein-Protein Interactions	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.979685
A-CA-04-2009(H1N1)_48Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.84993
Perturb_3841_KD_NFE2L2_ERP105460	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.4264
transport	GO Biological Process Annotations 2015	1.0	null
BRD-K03821002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56209
GTEX-OHPL-1326-SM-3MJGG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33577
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42921
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
Pituitary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.30089
3-isopropylmalate dehydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.577
Perturb_8142_KD_MATR3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.64849
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11021
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2291_OE_TBX3_SRP184219	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.9268
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.50903
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NUCB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02782
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20144
DTX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00427222
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051282
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62792
BRD-K85474153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03129
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1755
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Encephalopathy due to defective mitochondrial and peroxisomal fission 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
GSE227415_1_v_0_ucp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
L33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6334
WBSCR16	Pathway Commons Protein-Protein Interactions	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_24Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.01399
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ACADVL	Pathway Commons Protein-Protein Interactions	1.0	null
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5052
AFG3L2	Pathway Commons Protein-Protein Interactions	1.0	null
NALM-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
MFE280	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49728
GTEX-P4QT-2026-SM-3NMCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01454
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8124
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5774
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.15768
Monoclonal gammopathy of undetermined significance (MGUS)_Bone Marrow_GSE5900	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.58065
BRD-K85697068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39517
PECAPJ15	CCLE Cell Line Gene CNV Profiles	1.0	1.43642
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.0537
plant reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262304
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.168847
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle inner membrane	GO Cellular Component Annotations 2015	1.0	null
KALS1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.1486
H3K36me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4766-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07781811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42896
Oligospermia	CTD Gene-Disease Associations	1.0	1.1253
Multiple mitochondrial dysfunctions syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
Perturb_15457_KO_GPRC5A_SRP165862	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.04493
Perturb_17616_OE_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE137653_2_v_3_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.951204
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846348
18387200-Genes	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.201962
transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.083036
Cardiomyopathy, Dilated_Myocardial tissue_GSE3586	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.51065
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08493
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1_01_154	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58565
hydrogenosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.26709
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM5B	ChEA Transcription Factor Targets	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03536
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24631
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43395
BRD-K03916755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39558
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0126-SM-4GICC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35656
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48757
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE127970_1_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Processing of SMDT1	Reactome Pathways 2024	1.0	null
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.15899
KIAA0391	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26338
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3603
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HU-DNA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827385
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34463
umbilical artery	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCIH2228	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61318
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Venous endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
CRCGN015_MCF10A.TP53.M_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36893
SLC25A19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00818
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952668
MRPS28	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840673
MBD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10046
GTEX-VUSG-1526-SM-4KKZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954058
MRPL37	Pathway Commons Protein-Protein Interactions	1.0	null
PBK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81787
BRD-K62202988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47122
BRD-K35462157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37736
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25115
MARK3	Pathway Commons Protein-Protein Interactions	1.0	null
Biofilm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.748
BRD-K34110797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21317
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906243
NACC1	ChEA Transcription Factor Targets	1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47515
TRIM24_knockout_300_GSE19675	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63058
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32871
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54218
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.54888
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066783
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476864
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5496
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00842
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIMM50	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17747
PRDM14-21183938-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2228	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45943
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
OCIAML3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.56758
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040364
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7421
adrenal_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.04522
KDM1A	ENCODE Transcription Factor Targets	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23276
NDUFA9	Pathway Commons Protein-Protein Interactions	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9428
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.38116
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bj	HPA Cell Line Gene Expression Profiles	-1.0	-0.860532
GSE88819_6_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17786_KO_LDBI_SRP071739	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.99368
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.21668
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6827
EHMT2_KD_GSE34925_693_human_MDA-MB231 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCIH1930	CCLE Cell Line Gene Expression Profiles	1.0	1.39527
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33499
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43305
BRD-K77425312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42417
Bonemarrow	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.42392
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.6573
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6677
WB-82-EL69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255513
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A72E-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64593260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53937
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831141
larva	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.514924
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95788660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10484
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.99779
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
8520_STK32C_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573959
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.86027
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82201
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53029
Lipoprotein (a) levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
GTEX-U3ZM-0226-SM-4DXTA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60035
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SF126	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.0844
Perturb_313_KO_CARM1_SRP279319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPL11	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YW-1426-SM-3MJHF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879204
Somatic embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.094548
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Optic atrophy 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.64
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917533
CTCF_GM12870_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3-methylglutaconic aciduria type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
COPS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18368
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.42957
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331196
HFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0126
ventral claustrum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.971689
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BT-483	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.37729
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80752
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91677
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2796
PRDX5	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
SOX10_KO_GDS3480_257_rat_Schwannoma cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.47151
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-1326-SM-3NB1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32045
BRD-K67261586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21388
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MKN7	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.02687
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.078
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1993	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
PMC8482521-mmc13.xlsx-Phosphosites_48vhr_MLR-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Autosomal recessive spinocerebellar ataxia 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.848
Ink	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3553
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dystonia	DisGeNET Gene-Phenotype Associations	1.0	null
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.68
NANOG-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9629
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987704
BRD-K14645917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2005
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1	ChEA Transcription Factor Targets	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76616863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0012
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3607-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58142
t-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_8919_KD_ARID1A/P300_SRP256204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.06739
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4538	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE149075_6_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FASTKD2	Pathway Commons Protein-Protein Interactions	1.0	null
CAL-148	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE203308_7_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17122222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38396
BRD-K93496326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33862
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35755
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902645
BRD-K25256659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18346
GTEX-T2IS-1526-SM-32QPR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957898
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548m	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866826
BRD-K09304381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16978
GSE192771_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20771
GTEX-TMMY-1626-SM-4DXTY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18132
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CD68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57786
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4335056-pone.0116726.s005.xlsx-Biol_2_QE_NOT_FT-GENE_Official_symbol_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Ubiquitin activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19103
BRD-K15943105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21219
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6141
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70273
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872453
BRL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21405
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18757322-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
binding	GO Molecular Function Annotations 2015	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
HEYA8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3664
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K02066524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35849
Perturb_7935_KO_VTRNA1_SRP252980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.43505
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6414
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91423144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18806
Psmb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.218
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.92769
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265546
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3385-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-BatSRBD_12Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.7116
Type III protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.145
Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944135
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16526
LRIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36431
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.51803
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KDM1A_KD_GDS5055_367_mouse_adipose tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_1094_KO_ATXN1L_SRP230198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.28142
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322323
P63_DEPLETION_GDS2534_63_human_ME180 cervical carcinoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.56427
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53223020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34867
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3725
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6213
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GAPDHS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14007
RAD21_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.91697
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988596
Perturb_3573_KD_JAB1_SRP222371	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_10096_KD_AGO3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.89058
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886709
CBX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.30775
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.589004
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.239
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12709183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87312
SLC25A1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47049026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74126
WSUDLCL2	CCLE Cell Line Gene Expression Profiles	1.0	1.36179
H3K36me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCA4	ChEA Transcription Factor Targets	1.0	null
UQCRC2	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS34	Pathway Commons Protein-Protein Interactions	1.0	null
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.965418
LHX1_KO_GDS2748_298_mouse_embryonic renal vesicles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SHSY5Y	CCLE Cell Line Gene Expression Profiles	1.0	1.52133
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV5-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.06
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2993
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53307
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15179
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062575
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48586
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4599-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pioglitazone_rattus norvegicus_gpl341_gse21329	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268872
RAD21	ChEA Transcription Factor Targets	1.0	null
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K02061146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.91138
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89395
OV-17R	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.00978
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052591
Perturb_2370_KD_PRPF8_ERP116477	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.75682
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.239799
GTEX-VJYA-0526-SM-4KL1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87207
BRD-K73027631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50448
Eyespot apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.714
SARS2	Pathway Commons Protein-Protein Interactions	1.0	null
EVSAT	CCLE Cell Line Gene CNV Profiles	1.0	1.84764
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7414-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10286
BRD-K22449045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16857
GATA2	ChEA Transcription Factor Targets	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPL43	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890327
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410136
GADD45GIP1	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
SKMEL31	CCLE Cell Line Gene CNV Profiles	1.0	1.38609
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
B4GALT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00302
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2575_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.7065
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29424
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_BOUND_BY_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH2052	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22586
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Basophilic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
JAK2_knockout_79_GSE26188	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.82318
EB-09-GW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200695
k22	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.54
Phagocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14599
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4352
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XB-22-LI07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258201
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053416
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361826
GTEX-NPJ7-0011-R1a-SM-3GACT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04018
ALDH18A1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.956394
MRPL10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060218
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.960391
HDAC2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3121-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71A-01A-22R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL12	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03009
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.55638
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leukemia_promyelocytic-HL-60	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.44756
maintained	GeneRIF Biological Term Annotations	1.0	null
6480_PMPCB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.596105
embryonic lethality	MPO Gene-Phenotype Associations	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212442
BRD-K55518911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75338
OXA1L	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K66032509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35256
MCAT	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24167233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1941
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9535
Perturb_2919_KD_Obf1_SRP237554	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.34191
mpp	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059176
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900459
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A26S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09554
Perturb_13393_KD_AHR_SRP154013	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.93505
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUMO2	Pathway Commons Protein-Protein Interactions	1.0	null
OE19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7505_OE_ADARB1/ILF3_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.72707
mitochondrial calcium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
GSE158197_2_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.01
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260175
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.8926
Mitochondrial ribosome	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
control	GeneRIF Biological Term Annotations	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.970407
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217068
Perturb_12953_KO_ZFP36L2_SRP251843	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.43743
NoRC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.461
endopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
BRD-K88936403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29493
Perturb_8841_KO_PSMA3_SRP281428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.4341
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.695514
FOXN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4589
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CEBPB_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.886683
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3896
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
MRPL15	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFAF3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3667_KO_FASTKD_SRP277516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.76071
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0961
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MUT	Pathway Commons Protein-Protein Interactions	1.0	null
NB(TU)1-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.274039
SYK_druginhibition_285_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.98072
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089374
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15675930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30212
MRRF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
RBBP6	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPL4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28674
Perturb_15557_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.35157
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00981
gp16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.166
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.792023
Perturb_13012_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.5814
BRD-K00808919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25435
BRD-K89063617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1319
Perturb_9970_KD_WDR43_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.58215
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial matrix	GO Cellular Component Annotations 2015	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997248
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829529
GATA1	ENCODE Transcription Factor Targets	1.0	null
OVCAR5	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.848359
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8171-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-Fig7e-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.990255
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040236
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Body mass index (age>50)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7355_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.59846
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0368
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02649
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43425
increased cornea thickness	IMPC Knockout Mouse Phenotypes	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_7376_KD_RBM39_ERP105778	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.21271
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295043
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5749
Kidney Chromophobe_KICH_TCGA-KN-8418-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00717406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14973
thioredoxin-disulfide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71054
MRPL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56026
BF-94-NX85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20071
NCI-H441	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
GTEX-XUZC-0226-SM-4BOO7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29345
BRD-K99100679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65811
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0308
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
ECH1	Pathway Commons Protein-Protein Interactions	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1665
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69959
GSE128730_3_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
Femur bone mineral density x serum urate levels interaction	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0699
MDA-MB-453	GDSC Cell Line Gene Expression Profiles	-1.0	-2.58505
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.783
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A69Q-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MHC class I protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.515
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37379
protein processing involved in protein targeting to mitochondrion	GO Biological Process Annotations 2025	1.0	null
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73075421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34113
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Combined oxidative phosphorylation deficiency 34	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.9199
BRD-K41189799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4585
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADGRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06587
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K60719499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49233
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08322
SLC25A18	Pathway Commons Protein-Protein Interactions	1.0	null
Body mass index x sex x age interaction (4df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.652288
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08076
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17055
MRPS11	Pathway Commons Protein-Protein Interactions	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.471441
H3K36me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4375
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3445
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6714
CTCF	MotifMap Predicted Transcription Factor Targets	1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14253_KD_QKI_SRP272585	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.71212
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-2226-SM-4KKZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00437
TBP	ENCODE Transcription Factor Targets	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0317
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.06588
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1143	CCLE Cell Line Gene Expression Profiles	-1.0	-2.64796
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50109
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4747-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS16	Pathway Commons Protein-Protein Interactions	1.0	null
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962057
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2882_KD_MAGOHB_SRP144009	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.3795
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98707
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12801_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
TE6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69057
BRD-K93675803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42346
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14155_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Network map of SARS CoV 2 signaling	WikiPathways Pathways 2024	1.0	null
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9554
Perturb_14117_KD_RPS6KB1_SRP187713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.36744
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18556
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6973
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.65731
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999845
BRD-K67813189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01227
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-761	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE135030_3_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRPL21	Pathway Commons Protein-Protein Interactions	1.0	null
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.4082
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211994
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40371
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306129
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.35498
PTCD1	Pathway Commons Protein-Protein Interactions	1.0	null
Charcot-Marie-Tooth disease X-linked dominant 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
SET2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73401
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.8798
Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	165.836
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.396
K-562 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	2.21371
MRPL39	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EP300-20729851-FORBRAIN_MIDBRAIN_LIMB_HEART-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14828
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06906
GRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37046
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A7U0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01148
BRD-K44722555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55392
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
Proteasome storage granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.909252
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
ERAL1	Pathway Commons Protein-Protein Interactions	1.0	null
AURKA_druginhibition_196_GSE57810	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.09264
BRD-K30117087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47383
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-17-WP43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378299
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rt1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
increased cornea thickness	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_10153_KO_ARID4B_SRP255645	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.56502
cell part	GO Cellular Component Annotations 2015	1.0	null
HK1	Pathway Commons Protein-Protein Interactions	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28699
USP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08515
NOA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26993
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2284
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.99779
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE221932,GSE222115_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
CLPX	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69191922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59625
BRD-K66408914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08704
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.0839
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87615_1_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84488
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60578515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05437
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIRT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16674
GTEX-S3XE-0126-SM-4AD4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0169
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05541
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	127.104
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.724
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056441
tamoxifen_homo sapiens_gpl570_gds4095	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12658036-41598_2025_25964_MOESM5_ESM.xlsx-Sheet1-Supplementary_Table_1_The_list_of_546_proteins_specific_to_pLV3-CMV-AR-TurboID_H2O2_group_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.52428
BRD-K84459640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25631
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05717
DAUDI	CCLE Cell Line Gene Expression Profiles	1.0	1.48271
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839148
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10745
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6826
NELFE	ENCODE Transcription Factor Targets	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9668_Mut_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.12428
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23406
Perturb_9922_KD_PCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.01398
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7505
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.7594
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.65125
PPAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68266
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.7146
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-02A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BeWo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE149075_1_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A820-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31536290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42209
TFB1M	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NP-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNMTL1	Pathway Commons Protein-Protein Interactions	1.0	null
proteolysis	GO Biological Process Annotations 2015	1.0	null
Phosphopyruvate hydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.07
NFE2L2_Mutation_GDS4498_597_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.16468
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203308_7_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MOV10	Pathway Commons Protein-Protein Interactions	1.0	null
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16825
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986483
BRD-K60429174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01226
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.170114
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.07804
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39606
PE-CA-PJ15	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.33678
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.32547
BRD-K38706080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52104
PMC6044369-oncotarget-09-29162-s002.xlsx-TableS5A_MYC_target_FPKM-Table_S5A_FPKM_values_of_MYC_target_genes_Related_to_Figure_5A_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866327
lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88224
HDAC6	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME2	Pathway Commons Protein-Protein Interactions	1.0	null
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
4926_MEAF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560083
Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.99421
Kinetoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypomyelinating leukodystrophy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
Perturb_7247_KO_CTNNB1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.43709
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79916
NY	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41664
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8027
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic lethality between implantation and placentation	MPO Gene-Phenotype Associations	1.0	null
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-607	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
u26684	HPA Cell Line Gene Expression Profiles	1.0	1.41166
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.059
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
SLC25A11	Pathway Commons Protein-Protein Interactions	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6767-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal survival	MPO Gene-Phenotype Associations	1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.9341
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54007898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0522
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50237
GTEX-OXRK-0126-SM-3NB1E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09795
CTCF_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36877
retrograde	GeneRIF Biological Term Annotations	1.0	null
SC-58125-542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74391203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32459
BRD-K04877855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14939
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383004
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0063
BRD-K52190624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6217
PMC4521181-oncsis201520x8.pdf-207-CEBPA_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.302
BRD-K22606370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00051
Cyanelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.849
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.7872
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8057
Perturb_7180_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.39357
16455954-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_15558_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.29109
LB2518-MEL	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.95987
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-59-RG09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225387
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
MDM2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-0126-SM-48U27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26023
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880788
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9886
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.80903
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6123
POU5F1	ChEA Transcription Factor Targets	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40337
MRM1	Pathway Commons Protein-Protein Interactions	1.0	null
FASTKD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55G-0126-SM-48FDS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22329
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
mitochondrial processing peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.84292
intracellular organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.073519
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09959
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.855105
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9997
ion binding	GO Molecular Function Annotations 2015	1.0	null
GSE203017_0_v_1_irs2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR2C2	ENCODE Transcription Factor Targets	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84745303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14501
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.7432
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
BRD-K15977595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46878
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14884_KO_H12_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.53774
Combined oxidative phosphorylation deficiency 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.757
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCFL	ENCODE Transcription Factor Targets	1.0	null
HCC38_BREAST	CCLE Cell Line Proteomics	1.0	2.01825
Perturb_7242_KD_CNOT1_SRP285534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.56365
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
BRD-K56470219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1819
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HRA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
hsa-miR-548f	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271793
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.1389
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dental plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
Perturb_10051_KD_PRPF8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.04205
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial cloud	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.923
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_3637_KO_BLVRB_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.56204
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01388
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7416_KD_METTL14_SRP040278	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.7317
Perturb_4894_KD_ZBTB12_SRP158631	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.16257
KELLY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6605
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS12BM	Achilles Cell Line Gene Essentiality Profiles	1.0	1.44122
MCU	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-0426-SM-48TZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03143
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.923572
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6621_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.45276
EZH2	ENCODE Transcription Factor Targets	1.0	null
Umbilical cord blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3622_KO_SMARCC2_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.83533
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26293
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03613
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X3-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1175
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.125
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980446
Perturb_7423_KD_DKC1_SRP045222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.48135
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01534
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.672324
Liver Diseases	CTD Gene-Disease Associations	1.0	1.10353
MRPL44	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21712
Lung adenocarcinoma_LUAD_TCGA-73-4666-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15332
hsa-miR-1183	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Histone locus body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.978
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	109.065
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15795
BRD-K80763723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04621
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-FigS7d-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCND1	ChEA Transcription Factor Targets	1.0	null
A2058	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.35107
SHMT2	Pathway Commons Protein-Protein Interactions	1.0	null
Vastus medialis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.029
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15304
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900459
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86992
Perturb_7323_KO_DCP2_SRP070463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.42881
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10341
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.43971
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PEDS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15357
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.981269
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855503
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204613
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12551
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31011
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33935
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K71574401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19863
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327155
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
hsa-miR-4278	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
EIF3E	MSigDB Cancer Gene Co-expression Modules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A678-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3493
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.847092
BRD-K04116560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13924
BRD-K72866723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25603
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29068
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFV1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28982
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00228
mortality/aging	MPO Gene-Phenotype Associations	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_9940_KD_MAK16_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.65835
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51253991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11448
Perturb_13016_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
hsa-miR-374c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05693
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45576
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4491
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9395
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832542
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392091
DC-51-WE27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206897
TCF12	ENCODE Transcription Factor Targets	1.0	null
Perturb_5562_KO_MTSS1_SRP266832	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.82283
Chronic progressive external ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
BRD-K89931949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13967
Perturb_5395_KD_LIM1_SRP402415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.44816
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SIRNA_EIF4GI	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00999
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3225
IRF3	ENCODE Transcription Factor Targets	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26925
6-phosphofructokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.772
UBTF	ENCODE Transcription Factor Targets	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.988815
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258763
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972268
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839849
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423952
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04929
GTEX-P4QS-1326-SM-3NMCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64111
ATAD3B	Pathway Commons Protein-Protein Interactions	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.85906
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2794
SAP30	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A685-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62472719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83919
Autosomal recessive spinocerebellar ataxia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.896
Atrial heart septal defect 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3561_OE_MYC/HHEX_SRP174604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45164
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.426
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.985662
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2795
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.02763
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
BRD-K09250647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16947
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01331
protein localization	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S8-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79984
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.984
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21893
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900147
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.070032
calcium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
Perturb_10001_KD_FMR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.39149
GTEX-TMMY-0126-SM-4DXTP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64604
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
filariasis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.939119
Perturb_15562_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.97289
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53168433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05354
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K55053106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0363
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
alphaT3-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3189
BRD-K61934967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35863
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88964321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77234
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10626
pseudocumene	CTD Gene-Chemical Interactions	1.0	null
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25176
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82910696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56929
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056482
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19885
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Monopodium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.742
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394666
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.8088
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.940263
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
MRPS5	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3150b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
H3K9ac_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PB-09-OE00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21964
ATF2_01_206	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.57524
U-118-MG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.48697
NCI H322M	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.56443
BRD-K43820045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21026
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.980758
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24709
BRD-K64591035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38493
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A6GE-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_2day-MOI-10^4_None_GSE37572	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.6606
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sengers syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.523
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331906
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43282617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1733
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52601
cation binding	GO Molecular Function Annotations 2015	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12176
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.833009
MTPAP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44224
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2172
TE5	CCLE Cell Line Gene CNV Profiles	1.0	1.40268
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07918
ATP5F1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7867
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	2.45257
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.273
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.344
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46312
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7043
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944977
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4622
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40449
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.15729
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48255349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.195
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942035
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506753
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.531358
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF625	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21443
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.154
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.952801
protein targeting	GO Biological Process Annotations 2015	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29278
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GPX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07179
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MEL-3	GDSC Cell Line Gene Expression Profiles	1.0	1.96563
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340795
DDX49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28399
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74879991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10579
BRD-K42081955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10186
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051894
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60948317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30673
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8358
MAFK	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_2319_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.73953
GTEX-P4QT-1326-SM-3NMD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95494
BRD-K60453579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25133
BRD-K39925250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22309
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23655
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849233
lm13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
7751_SEC61A1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.676862
Heschl's gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936185
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.7878
MRPL16	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4701-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.36905
6889_PSPH_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.880453
SIX5	ENCODE Transcription Factor Targets	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38864
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2157
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Calu-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.88694
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24416
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	6.66353
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42729
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
9065_DMAC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547549
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661788
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9866
GTEX-P78B-1826-SM-3P5YX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884513
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.184
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91686
PCI-15A	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.34102
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPS6	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
endothelial	GeneRIF Biological Term Annotations	1.0	null
CALU3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.56767
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Abdomen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.242
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2170_LUNG	CCLE Cell Line Proteomics	1.0	2.79227
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	-1.0	-2.00163
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCCB	Pathway Commons Protein-Protein Interactions	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986359
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6682
PMC12335956-BNEO_NEO-2024-000529-mmc1.xlsx-2_chr7essentialAML_DepMap-THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3130-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.940198
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14828
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11543
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4685-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4473	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Perturb_3627_KO_HDAC2_SRP355605	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.835
Immunodeficiency 44	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVSAT	CCLE Cell Line Gene Expression Profiles	1.0	1.3609
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77653
SLC31A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6387
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8661
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21785
METTL17	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858017
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05393
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
POU5F1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0107
BRD-K59402582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12617
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31461
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CE-04-PX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438256
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.852599
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J4-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37421
BRD-K99077411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02733
GTEX-W5WG-1126-SM-4LMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31493
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32709
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.773147
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45576
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79982586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02297
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51862
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6483
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83336
BRD-K68732617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64732
SARS-CoV_60Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.87487
EB-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902645
Perturb_7221_KO_EZH_SRP321650	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	3.56334
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7889-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58892587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67735
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.1173
BRD-K87790666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08993
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OLIG2-26023283-AINV15-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Formate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.777
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12240312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44901
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALDH1L2	Pathway Commons Protein-Protein Interactions	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01208
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08725
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9761
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34007
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14087
BRD-K61556970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36348
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5249
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOMO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90881
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL40	Pathway Commons Protein-Protein Interactions	1.0	null
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
Mitochondrial DNA depletion syndrome 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4897
hsa-miR-767-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-369-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K19573822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65563
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.39485
MYC-27129775-CHIP-SEQ-CORNEA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09267
SOX2-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A875-01A-31R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81647747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00629
NB13	GDSC Cell Line Gene Expression Profiles	1.0	1.82856
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64403
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0474
substantia innominata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.866436
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898559
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cyclophosphamide_rattus norvegicus_gpl1355_gse48407	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RXRA	ENCODE Transcription Factor Targets	1.0	null
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.919759
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00785
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
lung_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.956121
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93324
hsa-miR-1298	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
ES6	GDSC Cell Line Gene Expression Profiles	1.0	2.0387
Perturb_13010_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PARK7_KD_GDS3750_2_human_SH-SY5Y	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36382
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9231
TEFM	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-384	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
POU5F1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Absent Speech	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961188
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.970852
BRD-K10221669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45908
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4287	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-30a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VDAC3	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K07802542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19123
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.557367
Inner dense plaque of desmosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.489
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30038
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06638
SOX2-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_10120_KO_RNH1_ERP021688	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.42014
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.978
Mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4911
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975461
AUP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30435
mitochondrial	GeneRIF Biological Term Annotations	1.0	null
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903473
Outer membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSC-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_2526_KD_ZRANB2_SRP185438	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.62143
BRD-K11331752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41601
BRD-K94014790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1873
Perturb_7157_KD_NEAT1_SRP366384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.6276
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06444
BRD-K76558091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32127
BRD-K53552465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00803
SALL4-18804426-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.049
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
NCIH322	CCLE Cell Line Gene CNV Profiles	-1.0	-2.29474
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278245
ZFX_KD_GSE43021_130_human_NOMO1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.113
Perturb_2666_KD_JUN_SRP357624	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.41946
valproic acid-629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
C6orf203	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6480_KD_SNRPB_ERP011528	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.188
BRD-K60759770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08365
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055027
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM33_knockdown_304_GSE32903	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.90825
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
L-540	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.31802
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9227
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6845_KO_ABCE1_SRP244437	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.6293
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14732815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08976
prostate gland	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.35256
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77031
Perturb_11691_OE_MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.049
BRD-K29745629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54492
establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU8686	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13429
SIN3B	ChEA Transcription Factor Targets	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.993447
BL825 (HLTF)	NURSA Protein Complexes	1.0	null
BA-59-EN38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351806
GSE221327_8_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902645
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462063
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902645
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72050003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.626
YA-34-DT48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241057
16527891-Table3	GeneSigDB Published Gene Signatures	1.0	null
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STOML2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46453
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24846
Ornithine carbamoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.152
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0274
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.358
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Perturb_6856_KD_CNOT1_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.0753
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABCB7	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.91863
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43316594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42531
REH	Achilles Cell Line Gene Essentiality Profiles	1.0	1.10358
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Perturb_2330_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.02054
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.66667
Hereditary spastic paraplegia 9A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
Perturb_13008_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.767
Rad51B-Rad51C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.952
RBBP5	ENCODE Transcription Factor Targets	1.0	null
NCI-H2228	GDSC Cell Line Gene Expression Profiles	-1.0	-2.07197
urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Leucoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
ERLIN2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24106
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
8924_TIMM50_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55131
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PARS2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS24	Pathway Commons Protein-Protein Interactions	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01278
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial encephalomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
BRD-K79887921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24808
triggers	GeneRIF Biological Term Annotations	1.0	null
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.344
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
PAM16	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H716	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.46261
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25647
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41309
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10598
LETM1	Pathway Commons Protein-Protein Interactions	1.0	null
Abductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060773
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921186
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38510068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00037
GSE146074_6_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
vas efferens	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683919
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12828
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04692
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927515
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20906316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65884
BRD-K32839286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15811
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10499
E2F4	ENCODE Transcription Factor Targets	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.860811
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39489370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2472
MRPS25	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K8ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14037
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855227
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.214636
intracellular transport	GO Biological Process Annotations 2015	1.0	null
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342034
GTEX-R55F-1726-SM-2TF4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08033
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COX7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57629
ATP5G1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6097700-pgen.1007515.s008.xlsx-S2_Table-S2_Table_SATB2_Cort_gene-set_list_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JY-01A-31R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DYNC2I2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19536
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77113
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.28249
BRD-K25329768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08076
mc116	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
hsa-miR-429	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Perturb_9939_KD_KIF1C_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.44013
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863521
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03644
GSE113267_0_v_1_rfx7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72609445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44802
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.65017
SK-PN-DW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60204
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6759
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.869703
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95213130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44437
Planktonic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.416
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40873
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11692_KD|OE_SF3A3|MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3750_KD_NORAD_SRP149071	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80241
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03582
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PYCR2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K79777851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10272
AB-35-RU30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20277
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9633
SUMO1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.32861
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.069395
BRD-K14695950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07836
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3792_KD_MYC_SRP057613	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.64252
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41012
Necrosis	CTD Gene-Disease Associations	1.0	1.82516
organelle part	GO Cellular Component Annotations 2015	1.0	null
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.848611
G-401	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.98476
mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K84685162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10687
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4428
Perturb_7367_KD_H2BC21_SRP308810	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.00255
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347462
U266B1	CCLE Cell Line Gene Expression Profiles	1.0	1.40125
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DDX28	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-A6W5-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26628
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07729
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.94333
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31136
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.905729
Perturb_6857_KD_CNOT7/CNOT8_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.28635
Proplastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
D341MED	CCLE Cell Line Gene Expression Profiles	1.0	1.48804
Cerebellar Dysmetria	DisGeNET Gene-Phenotype Associations	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.6578
m-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910343
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.099804
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP63	JASPAR Predicted Transcription Factor Targets	1.0	null
59M	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7975
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412464
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.8696
18199535-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_7863_KD_METTL3_SRP226173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.10092
SP4	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85500722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16682
BRD-K76661445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9227
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.908594
BRD-A59009217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07969
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41892
ZNF263	ENCODE Transcription Factor Targets	1.0	null
Perturb_9170_KD_CFTR_ERP118933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.06593
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957812
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MV-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fruit	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262986
SA1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37673
Perturb_8086_KD_EIF4G1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.56232
RPL37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36934
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18123
Kidney Chromophobe_KICH_TCGA-KM-8440-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7533_KO_HDLBP_SRP255633	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.21898
NANOG-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Olfactory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235029
SUPT7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65541
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.3255
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_6616_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.21456
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.094
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4704-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372456
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
RELA	ENCODE Transcription Factor Targets	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10345
hsa-miR-200b	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14586_KD_IGF2BP1_SRP291710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61659
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7886-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97393
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4905_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.02572
Chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999922
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2857
BRD-K59006776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90631
MAX	Pathway Commons Protein-Protein Interactions	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043589
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.539709
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26346
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071105