association	dataset	threshold value	standardized value
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84148,GSE96938_0_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72717797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3886
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Aril	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
GRTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12306
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
FGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555745
GSE223008_9_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34232791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6264
STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4505
STAMBPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470142
A549_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145072
U2-type precatalytic spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.077
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31932
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291952
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.85822
BRD-K70992537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35852
BRD-K08982277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05013
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sporulating cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.763
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
Pyridoxine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0159979
K562_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206021
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147527
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.528
NFATC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15364
A549_Rucaparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.014475
PMC11257629-media-9.xls-METTL3_KD_upregulated_Genes-METTL3KD_UPregulated_Genes_1694_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74694052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54948
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.987
Bendamustine_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230316
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78968
A549_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151037
Major Depressive Disorder	DisGeNET Gene-Disease Associations	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226164
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172407
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
TRRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37581
BRD-K99380757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88427
smc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.316
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88026
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158588
MCF7_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179678
TEF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00700784
GC-02-TV70_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290932
regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
BRD-K68303333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12328
MCF7_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144885
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K16682693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09798
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
KEAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673872
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
11235_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546605
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00989141
protein dephosphorylation	GO Biological Process Annotations 2023	1.0	null
Erythromycin_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0195752
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594368
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.664168
Intracellular anatomical structure	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
A549_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140475
BRD-K70537701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25099
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191643
LETM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14547
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NOX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632478
BRD-K34414758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36467
GZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41732
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Epothilone A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193257
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151368
CFL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00815675
A549_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235341
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.618866
Cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.799
BRD-K82187446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34996
CGAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0087987
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149196
BRD-K93153656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73232
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166768
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	162.682
FA-92-JL46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256498
BRD-K11566857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03141
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63275
BRD-K05586628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00347
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142481
BRD-K15400067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06017
Anterior pharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.111
JUNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40063
BRD-K49635910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.211
A549_Ellagic acid_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223878
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.671035
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91423
BRD-K46703028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35074
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180377_2_v_1_lipa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-61-DY35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23427
K562_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231968
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
P2RY13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00638749
BRD-K59049340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03575
TE11_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.00525
MCF7_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152751
BICR6_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	4.38848
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE146074_9_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258065
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306604
USPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29862
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248775
BRD-K67344728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04256
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
EW16	DepMap CRISPR Gene Dependency	1.0	2.51156
MCF7_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122443
A549_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251153
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234817
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71871382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00449
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347926
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0391168
7559_RRN3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.569074
BRD-K52225720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03238
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	191.787
BRD-K08723967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09511
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222971
MAPK1IP1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0040557
BRD-K82784817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99868
STEAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73277
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0310633
A549_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170308
K562_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189133
HEY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587322
TLCD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41366
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60830482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40752
BRD-K22701871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07967
MCF7_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289832
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01525
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ileal mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.694173
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508611
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.94717
AD-28-GJ71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451686
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
K562_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162431
K562_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141587
BRD-K61363662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22651
BRD-K72773309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45465
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151637
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARHGAP30	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00791842
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149747
BRD-K91277001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05072
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262959
MCF7_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268034
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
K562_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276279
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218033
BRD-K93933512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18271
BRD-K96768352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56416
GSE86507,GSE86509_4_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CatSper complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
COLO741_SKIN	CCLE Cell Line Proteomics	1.0	2.05135
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.733662
BRD-K79954583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60496
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0895
A549_2-Methoxyestradiol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209844
MCF7_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159879
BRD-K92210988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17693
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27825
K562_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178695
Breast disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
BRD-A43330902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00301
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6412103-mmc1.docx-5-M00695_ETF_P_8_350E-5_N_428_31_5_2_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.94256
BRD-K03141963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91304
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73531877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16561
Tou	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.517
MCF7_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162211
Ranolazine_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021538
Asi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.852
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74135
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191985
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213606
ARSG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614245
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212418
BRD-K85456301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03315
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333099
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38607769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89066
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
A549_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138578
PRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615548
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568143
MCF7_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168938
TTC9C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25972
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336021
magnesium-dependent protein serine/threonine phosphatase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340808
Blood vessel	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ileum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GJD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43638
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87779720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90437
A549_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159322
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	183.911
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149163
FSCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741353
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191107
A549_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262737
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513697
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25559
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280659
Intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
ACT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.058
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18033
A549_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146921
A549_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0109048
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183752
UBXN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50579
VSIR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00466577
NO36	DepMap CRISPR Gene Dependency	1.0	3.39007
GSE198794_0_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05253426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31692
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241479
K562_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148058
BRD-K18737347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05155
RT-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.126
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26926
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174053
CACYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58921
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
C2orf15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12969
BRD-K69543414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26896
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218072
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76258
GSE180951_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021207
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16911140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88752
Waist-to-hip ratio adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.42687
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26291
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.911
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0599
BRD-K42960858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05476
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_7_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124985
BRD-K54453373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29236
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56241426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03593
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481322
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247031
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45124
FAM104A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13029
VAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641862
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nuclear pore inner ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.047
BRD-K76087207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13817
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EB-09-GW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21016
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15924535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31394
A549_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146933
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.499399
CDK10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676971
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42435
MCF7_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193792
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268758
DCAF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16386
BRD-K71427375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02774
OVCAR-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.03
Brain morphology (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.00969
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180143
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186617
Breast carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
Tubulin folding cofactor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.033
A549_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161194
ZBTB7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591879
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188875
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76175734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85802
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156022
BRD-K55779851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2253
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07915
MCF7_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0412024
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134835
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67297
MN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13384
PMC11960529-mmc4.xlsx-Atrial_LHX2_KOoverCT-gene_LHX2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.015126
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153635
PMC9675280-12950_2022_317_MOESM2_ESM.xlsx-LPS_vs_control-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CALR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03533
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227543
BRD-K30853940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53994
GSE121198,GSE129779_0_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155941
BRD-K27265817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13035
GSE111035,GSE111040_8_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Menadione_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212101
A549_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140179
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11457257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13326
MCF7_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240013
BRD-K67229323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01602
BRD-K04257723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79012
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-28-GJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204926
Pre-mRNA splicing and ribonucleoprotein assembly	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
MCF7_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202077
IDH3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21037
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH647	DepMap CRISPR Gene Dependency	1.0	2.48819
BRD-K92712225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64531
MCF7_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207103
BRD-K45762887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21064
BRD-K02066524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10001
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13136
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
AC-98-QW77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225357
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57014223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04368
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4509
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4534
A549_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251771
BRD-K53458780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34437
PB-40-YB26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339523
GSE211963_0_v_3_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12909
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-134-HOXC12_HOXC12	Rummagene Transcription Factor Associations 2026	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
GPR176	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29803
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019843
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172429
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GNG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17068
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230837
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23845
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
BRD-K90693562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20046
BRD-K94441949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42174
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37424
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASPC1_PANCREAS	CCLE Cell Line Proteomics	1.0	2.22646
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Floret	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.095
RRM2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494262
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.555
GSE207301,GSE207303_0_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.4491
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0305653
MS4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00731479
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159439
Caryopsis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.074
BRD-K02778838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0301
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139736
AD-51-FB60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318987
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8649
Centralspindlin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3634
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117768
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CLUH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11715
BRD-K01850737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29672
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162583
BRD-K03352392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03367
PLXNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488966
Hairy cell leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
MCF7_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0300662
BRD-K36149853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63428
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170084
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256846
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4312
Thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.066
BRD-K49208610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18152
BRD-K28448768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24326
BRD-A83387524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4118
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212917
ZNF649	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15168
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163667
MCF7_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00941593
Belzutifan_NCI-H596	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0269702
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
HUPT4	DepMap CRISPR Gene Dependency	1.0	2.94274
BRD-K89110518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12426
BRD-K96493283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14136
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353014
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.9013
BRD-K91469267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58036
DMS-114 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.523
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215294
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164033
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149565
A549_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250306
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010854
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131347
CDK15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050973
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP2K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592983
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.797177
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019506
FAM169A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74646
BRD-K30199352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5578
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.3127
BRD-K89811208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28832
GMPPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00686268
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289331
BRD-K34192219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27025
9592_UNC45A_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517715
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426878
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174293
SNRNP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07268
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184919
MCF7_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243604
LDOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74689
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655424
ADH1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00881384
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIGLEC9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0078267
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48085
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241735
GSE179693,GSE179694_4_v_2_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Digitoxin_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00911257
T-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36743230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2961
MCF7_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275308
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7876
TRRAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606069
BRD-K73969016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20004
phosphatase activator activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K47821225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32991
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.289
BRD-K24496049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46105
K562_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168537
BRD-K82446079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9802
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.679022
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5638
RNASET2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0068563
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21074
Valdecoxib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.019838
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218446
BRD-K69491845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04936
A549_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017438
BRD-A07944983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16537
MPEG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639783
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261939
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76578941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30309
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216858
Budesonide_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0276348
A549_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203723
BRD-K10571700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17014
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3456
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.52431
SOCS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00883534
FABP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00457213
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78249980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30206
Hypodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.374
BRD-K86232198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42427
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU8	DepMap CRISPR Gene Dependency	1.0	2.38925
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.4302
CHCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08544
Bract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.137
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PGJ2_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7142_RBBP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4615
ZNF683	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102489
UBE2Q2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18848
CRCGN011_HEPG2_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33255
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JB-89-SI60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273278
PMC6684084-pntd.0007589.s007.xlsx-Sky_Blue_Module-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.545565
BRD-K52175660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63355
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.648305
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62158
BRD-K41746201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2552
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224359
A549_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206983
Alzheimer disease and age of onset	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.609691
PMC12178937-mmc6.xlsx-D_MAFF_KDvsD_C_deg_all-gene_id_MAFF	Rummagene Transcription Factor Associations 2026	1.0	null
SPPL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26158
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.934412
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126631
MCF7_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0286434
968_C12ORF60_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51152
PMC6411037-NIHMS981149-supplement-4.xlsx-Table_S3C-Table_S3C_List_of_human_SP-_PF-_ST-EPNs_and_ST-EPN-RELA_gene_sets_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0101749
A549_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107459
OUMS23	DepMap CRISPR Gene Dependency	1.0	2.37986
BRD-K76812105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50627
BRD-K92812209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28135
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.50932
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323848
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16611
Small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256959
BRD-K90571714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27151
GSE211866_2_v_1_usp11_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0922
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156457
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25417
A549_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212135
9687_UTP6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543498
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180364
SNUC1	DepMap CRISPR Gene Dependency	1.0	2.34657
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.551976
Neratinib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268714
KCNQ2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690528
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	217.607
BRD-K88583132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01675
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173379
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10199266-mmc2.xlsx-RUNX1-DEGs-Unnamed_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.44405
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244439
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
phosphatase activator activity	GO Molecular Function Annotations 2023	1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015639
MCF7_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125965
BRD-K79020643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11427
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2112
PI4KA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00458672
MCF7_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187742
BRD-K74660272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91895
MCF7_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190782
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.969542
Type 2 diabetes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.81549
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95460104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12078
FA-47-IB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253884
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226611
A549_Azacitidine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139616
BRD-A01403444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34238
Tassel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
TAK-901_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0632468
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149077
K562_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180116
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cotyledon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.095
GSE240809_0_v_1_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152727
EW22	DepMap CRISPR Gene Dependency	1.0	2.45066
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202123
BRD-K59930979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23481
OXGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063145
A549_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158608
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210889
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145691
MCF7_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019232
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.773478
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76023734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19923
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K48195722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31909
MCF7_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133898
GSE244710_3_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
URB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00704017
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoprot_AKT1_AKT2_KD_vs_SCR-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
JHU029	DepMap CRISPR Gene Dependency	1.0	2.31231
BRD-K10423475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51332
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224138
BRD-K16312305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30364
EWS502	DepMap CRISPR Gene Dependency	1.0	2.79673
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209773
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K78642007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10798
Almonertinib (mesylate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113884
SUPT20H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550041
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187041
Protein serine/threonine phosphatase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Meiotic spindle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
Red blood cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.939794
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546329
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
TF1	DepMap CRISPR Gene Dependency	1.0	2.15035
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHACTR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27649
Huelle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
Loperamide (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0147902
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154381
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4035
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340375
A549_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219225
RASSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51679
BRD-A94420133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28358
S117	DepMap CRISPR Gene Dependency	1.0	2.90675
BRD-K83244979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52565
GC-74-QF56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386554
BRD-K50271780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06363
GSE158834_1_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.035206
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
KDM4E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01666
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-62-MNT_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171198
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536336
BRD-K12531686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19612
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5159535-supp_gkw757_nar-00810-met-z-2016-File016.xlsx-S9_SOM-Unnamed_3_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me2_RS411_n_603_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
DB-51-UO66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270675
Phosphatase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.89159
Epicuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377128
BRD-K59938516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55549
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
CAMTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00506
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.90959
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329077
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128928
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21416096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20297
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-88-HT15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386839
PMC6828764-41419_2019_2062_MOESM2_ESM.xlsx-GATA3_UTX_promoter_gene-ENSEMBL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254036
GSE157383_6_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179254
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206593
GSE216394_2_v_0_pfkp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185987
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116299_4_v_3_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-63-SV27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328663
UMUC16	DepMap CRISPR Gene Dependency	1.0	3.54926
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013311
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTNND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10101
A549_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014465
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157347
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LTC4S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11108
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.638812
Tubulin inhibitor 6_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0287161
A549_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193495
UMUC5	DepMap CRISPR Gene Dependency	1.0	2.47645
MCF7_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132652
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.47788
CC-18-YW57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252636
PI4K2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600952
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169815
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79384
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27698
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287367
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LDHAL6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549913
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lucanthone_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0272986
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9474
GSE142210_11_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Precatalytic spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.726
A549_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0355008
olaparib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0198746
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75625428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27268
MCF7_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136232
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268479
BRD-K83459401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67442
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155093
PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100763
KYAT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00791209
A549_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162571
BRD-K50689779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86863
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19328
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.0961
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50829918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10753
GSE156978_1_v_0_dnmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181185
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515371
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24446
HCC827	DepMap CRISPR Gene Dependency	1.0	2.00351
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.263
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158874
GSE146687_2_v_3_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86978618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63651
MCIXC	DepMap CRISPR Gene Dependency	1.0	2.66984
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
LY-2584702 (tosylate salt)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0164649
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MLN8054_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135233
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mating projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.632
MCF7_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015225
A549_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163127
SETD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551757
K562_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135283
BRD-A77181042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17178
regulation of DNA repair	GO Biological Process Annotations 2025	1.0	null
VSIG10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66023
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.2277
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09832
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159517
K562_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207615
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.767526
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.55369
MCF7_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225061
ABI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00844769
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28295
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179135
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.2665
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7164
UA-39-TN76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254917
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154646
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00744417
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-59-EN38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226867
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.8222
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358427
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.4773
A549_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205205
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023481
K562_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165828
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.79
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE75209,GSE75212_0_v_1_halofuginone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0360993
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pimitespib_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0201208
PMC3371315-NIHMS350140-supplement-12.xls-MCF7-T47D-SK-453_Down_Common_xl-Supplementary_Table_5_Luminal_Signature_Genes_decreased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40367360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27466
RBM15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17326
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182813
A549_SRT3025 HCl_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207647
BRD-K88934376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11736
PBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1492
K562_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147559
MCF7_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194489
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77820593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71431
BRD-K47098496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01314
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77074748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16128
Enteric muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176542
SQLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02354
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198075
MFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82509
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9226
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233582
ZNF99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74291
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225471
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cephalothorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
A549_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221378
Cytarabine (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0261019
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206129
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167332
BRD-K58041870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46218
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1808
PMC11324510-41587_2023_1949_MOESM3_ESM.xlsx-Supplementary_Table6-Supplementary_Table_6_TP53_pathway_genes_list_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197992
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31037
Transcription export complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.424
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K80779045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39813
A549_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156297
MCF7_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101595
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142062
A549_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142935
Nectary	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
VCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01612
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPTAN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00385731
Scutellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.25
BRD-K25878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40885
BRD-K41323747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97386
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EF-85-DA07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201523
BRD-K53816426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3561
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636688
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.579463
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218414
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217308
A549_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147632
LN443	DepMap CRISPR Gene Dependency	1.0	2.0464
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59396
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170573
Red Blood Cell Count Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
MCF7_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.04154
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56472
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
K562_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231181
Werdnig-Hoffmann disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
Spindle midzone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.2601
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015384
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017967
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231747
Integral component of synaptic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.962
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94825
CRCGN011_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13897
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170274
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13995
K562_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134019
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Root pericycle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
A549_Iniparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.031006
TBX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502731
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195562
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236253
BRD-K96981233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5662
CRCGN009_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0706
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242439
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MERO95	DepMap CRISPR Gene Dependency	1.0	2.50256
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247591
K562_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152967
DYRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38617
Terminal loop	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.731
MCF7_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136634
MCF7_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107699
Bexarotene_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0241235
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0402575
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	2.59608
A549_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173838
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K55891520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14295
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85173
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21435
BRD-K41809155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62461
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154943
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54604127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66422
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155215
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455316
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396207
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_2-down-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79684522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48485
MCF7_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249385
ERCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05059
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234501
BRD-K78647367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34463
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393017
BRD-K72531838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08033
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1304
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
RISC-loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.984
PTGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069928
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.029
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MCF7_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016883
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588571
NDUFB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82203
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47426
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258725
MCF7_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0316041
BRD-K77706833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25446
NPC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00422597
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.44237
BRD-K29838935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18322
HeLa-S3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.869
BRD-K22775880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17656
BRD-A00522887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60709
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0284981
Root apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
CYSLTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531341
SLF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104992
BRD-K04363234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49502
BRD-K75775113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52052
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4677
MCF7_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131814
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172088
Ventral sucker	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
A549_PHA-680632_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138503
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.5
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44276
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
BRD-K21671578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37371
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1916
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMPRSS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545513
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nthy-ori 3-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
BRD-K01351858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79918
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CHLA10	DepMap CRISPR Gene Dependency	1.0	2.87342
Childhood spinal muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
MCF7_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0266092
BRD-K62718031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1536
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.6163
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Root tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.302
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.66762
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155094
MCF7_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300214
BRD-K43775480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21381
BRD-K32082369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3146
BRD-K04939366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11105
Prospore membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.994
MCF7_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014526
ML264_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0184876
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.36722
BRD-K65796649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20107
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79730625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37656
496100671_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00361
BRD-K47271260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78761
BRD-K58836556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51667
DF-57-BL63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37486
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120454
ACAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00462676
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
ME-16-XW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292817
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Leaf epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.013
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03744
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dephosphorylation	GO Biological Process Annotations 2023	1.0	null
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64874
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.665936
BRD-K62372121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10898
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131419
LN229_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.58193
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.98799
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155883
DGKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586278
BRD-K43594798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22836
GSE210885_2_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26649
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238036
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179455
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE62843,GSE64370_0_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
GSAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647225
SLC25A20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679813
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490623
MCF7_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179817
BRD-K39435284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51682
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
BRD-K81954791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33919
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
BRD-K46526566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15173
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261384
EA-00-RN06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311283
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155514
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.892769
BRD-K01285236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53859
MCF7_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245174
NCIH1836	DepMap CRISPR Gene Dependency	1.0	2.03935
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.401208
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
NMS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
PROSER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30182
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77242
GSE199606_3_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1548
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11962
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139876
9841_WDR75_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54347
7077_RAE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.577989
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesophyll cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
A549_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189907
GRIK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00800061
MCF7_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164848
Shoot apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.334
BRD-K31437957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65478
Intestinal mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153107
STK35	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602777
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73081
K562_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170132
BRD-K91354770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16709
BRD-K90625171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48742
BRD-K02100640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23198
CYP51A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485161
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556073
GBP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0038633
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hesperidin_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213193
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_5_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166047
BRD-K96733881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57456
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-41-IH69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211271
BRD-K46961295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29315
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68732617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23126
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368047
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03546
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
AC-31-PL89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307973
MCF7_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106236
A549_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137659
MCF7_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156011
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242619
MKN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ascospore-type prospore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.992
8230_SNRPD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12115
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
isoetharine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23482
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.520597
RPL37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00463965
BRD-K65828139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11472
A549_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249716
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62287
BRD-K54260552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06381
Microprocessor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
CRAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511236
Nuclear body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181221
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.548
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146336
BRD-K03243737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18025
BRD-K59130783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11809
BRD-K19770687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01837
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.033268
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_0_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20451745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27311
BRD-K86587289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97682
BRD-K84518331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07599
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
BRD-K50710005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13428
MCF7_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00938479
LY6G5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51216
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543115
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K01774461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93122
ZNF573	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524711
A549_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225797
K562_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146332
BRD-K02206127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08323
Outer kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.648
Decline in glucose metabolism in posterior cingulate cortex	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
GSE62843,GSE64370_4_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296771
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120797
BRD-K06577881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12298
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
Meloxicam_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0186044
Zileuton_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0234792
BRD-K31666794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65036
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164357
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137069
A549_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020372
GSE153189_1_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ribociclib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221221
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93496326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06144
BRD-K56987307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22076
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19381111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03738
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89065802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18435
SCARA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563327
protein phosphatase activator activity	GO Molecular Function Annotations 2025	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
Idoxuridine_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145443
TRAPPC3L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676357
Erdafitinib _SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0252448
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159555
GSE143643,GSE143644_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254749
K562_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226119
AMER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13578
MCF7_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138399
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
CORL23_LUNG	CCLE Cell Line Proteomics	1.0	2.6709
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.2602
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.9916
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171468
4-P-PDOT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36516
BRD-K04650671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06784
Spindle pole body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
BRD-A82976259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53891
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Cytarabine_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0290849
A549_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204177
Maxillary nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1805
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254812
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29017
Cuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.292
BRD-K81706364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26909
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.66701
GSE62843,GSE64371_2_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23841
MCF7_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189334
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66707905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2892
TREML4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699386
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286615
KLE	DepMap CRISPR Gene Dependency	1.0	3.03433
BFTC909	DepMap CRISPR Gene Dependency	1.0	2.37992
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14913
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235967
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01338
APOBEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15619
EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER	ChEA Transcription Factor Targets 2022	1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.68235
BRD-K76329122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50129
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172288
A549_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206708
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RHJT	DepMap CRISPR Gene Dependency	1.0	3.39881
RPL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0110771
BRD-K74302837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03772
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151119_3_v_1_hsf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161614
RHPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11684
MCF7_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123747
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234863
Ileocecum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
OS252	DepMap CRISPR Gene Dependency	1.0	3.11488
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31829
PRKCI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593254
Posterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45134469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09802
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150374
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016999
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16392
BRD-K49878220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09786
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19323
protein serine/threonine phosphatase complex	GO Cellular Component Annotations 2025	1.0	null
MCF7_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0339095
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01491
2120_DDX41_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14857
MCF7_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215999
Orlistat_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190283
PH-797804_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.010133
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC10920339-Table_3.csv--Table_S3_MR_analysis_of_gene_set_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227065
BRD-K91467755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4213
NUGC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517287
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150655
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444927
BRD-K88282877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84851
BRD-K52190624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19356
BRD-K36566880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77303
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173744
A375SKINCJ1	DepMap CRISPR Gene Dependency	1.0	2.57884
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154825
PMC9578007__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Ralimetinib dimesylate_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0294314
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148852
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.813
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015414
A549_PFI-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139304
A549_Aurora A Inhibitor I_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116486
MCF7_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120455
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10095
GSE88819_11_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K20253608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37894
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248593
BRD-K38929751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01354
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544902
GSE62974_1_v_0_epas1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10247733-41408_2023_863_MOESM2_ESM.pdf-468-SMAD5-AS1_SMAD5	Rummagene Transcription Factor Associations 2026	1.0	null
QE-48-NG07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265641
KKU100	DepMap CRISPR Gene Dependency	1.0	3.58231
BRD-K32120119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91219
9454_TXNIP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521249
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JA-79-II25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210408
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130138
A549_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198115
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.40447
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15193
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mean spheric corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.25229
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173663
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65307
Meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.257
A549_TMP195_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139661
Vascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
STK35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20059
Neurosecretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.696
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267196
CTV1DM	DepMap CRISPR Gene Dependency	1.0	3.21131
BRD-K56214240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06472
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158391
K562_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233089
BRD-K42138859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31023
NACA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19566
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.684
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155166
BRD-K28995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24795
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149742
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K08715918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61985
TYK-NU	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155885
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.8428
A549_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239333
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FDPS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00404032
BRD-K64091938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25686
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Aleurone layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
SRRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2189
A549_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195446
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150614
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48029682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00447
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79241
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
CERF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
A549_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175917
BRD-K25408656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03556
BC-62-RZ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235588
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149414
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146848
SCN4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617931
A549_Iniparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232926
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.53139
3501_GPKOW_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.67224
BRD-K61033092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06371
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44647
6283_PHF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527142
SKLU1_LUNG	CCLE Cell Line Proteomics	1.0	3.17977
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
U5 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-03-XC62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.537468
SST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581435
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCC4	DepMap CRISPR Gene Dependency	1.0	2.07574
BRD-K89471250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37485
EHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82959
BTN3A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636087
BRD-K80593371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46606
Small intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
protein modification process	GO Biological Process Annotations 2023	1.0	null
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23405
BRD-K24226959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09183
MCF7_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147597
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218986
lxf289	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.479
SZT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03163
CHLA266	DepMap CRISPR Gene Dependency	1.0	3.95263
MCF7_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205429
7471_RPL39_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528386
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351328
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05859
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
Bergenin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183902
BRD-K82805160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35906
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21327356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3164
MPP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00953535
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
YSCCC	DepMap CRISPR Gene Dependency	1.0	2.36588
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08178
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63766
RBM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23606
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162924
Daytime sleep phenotypes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
A549_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183618
A549_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148132
CRCGN014_HEPG2_3H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35517
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21185
BRD-K22045035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80805
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF233	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28512
PPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00410149
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195199
FFAR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478556
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2-phenylmelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26689
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285832
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144167
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.592535
PMC4330385-supp_gkv024_nar-03005-x-2014-File010.pdf-113-PROX2_PROX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCM8-MCM9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.632
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155111
MORN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623895
WNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614537
Glycogen storage disease I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
A549_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014135
BRD-K90858591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38228
EC-86-EK93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205989
Rectal prolapse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rpd3S/Clr6-CII complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
PMC3500769-srep00875-s3.xls-PAX2-Time_1_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278265
Malignant ovarian surface epithelial-stromal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.7126
HSOS1	DepMap CRISPR Gene Dependency	1.0	2.35247
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HHEX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556247
Ranolazine_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0092639
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.195
BRD-K54066059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07478
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U4/U6 x U5 tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013342
Mean reticulocyte volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.60969
JHU022	DepMap CRISPR Gene Dependency	1.0	2.26184
BRD-K06489778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38552
K562_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171403
BRD-K51849151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93978
BRD-K96389533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.026
BRD-K44935022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38274
PMC9338313-41467_2022_32034_MOESM4_ESM.xlsx-Control_HS_0-Table_S1_HSF1-interacting_proteins_enriched_upon_heat_shock_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8045971-Table_3.xlsx-vs_LPS_ctrl-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28601178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41378
BRD-K03902789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19237
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4415
BRD-K33951208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71116
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_2_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142733
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11730256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6686
PDF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49308
A549_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317787
NCIH2172_LUNG	CCLE Cell Line Proteomics	1.0	2.28898
CST6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00696755
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10350077-media-8.xlsx-PPM1D_tr_LPS_vs_Cont_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TNFRSF19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573464
MCF7_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175331
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78323315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17982
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
CLDN11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584965
GSE239578_2_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovarian carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
A549_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164866
APEX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34442
BRD-K65733046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2648
Nevirapine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0053832
HADHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614268
BRD-K72685049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55169
A549_ZM 447439_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231735
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127945
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10618
BRD-K26758344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36355
GSE160817_7_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501306
MCF7_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023215
BRD-K86938753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18495
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206702
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264057
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Pracinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117568
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00762034
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56034970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08459
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cellular anatomical entity	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419563
BRD-K31093279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05386
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53127464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01844
Mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023811
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283876
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14646
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153614
PANK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535929
MCF7_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234659
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.543356
NXPE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14744
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318051
BRD-K17675924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04771
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
MCF7_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300105
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00688001
KYM1	DepMap CRISPR Gene Dependency	1.0	2.41053
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00982117
Aorta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Larval integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
S0-EE-Y96U_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295503
A549_Tucidinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160177
Chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.014337
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201044
BRD-K76174882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0633
OR10V1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051635
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.015
Ritonavir_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0130103
Apalutamide_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199181
PMC11462941-CAS-115-2947-s001.pdf-40-RFX3_RFX3	Rummagene Transcription Factor Associations 2026	1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61083
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0431727
MCF7_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202537
MCF7_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151397
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523982
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JC-63-DO70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201449
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117264
MCF7_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145854
POLE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00452995
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133005
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ellagic acid_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125827
STK33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588813
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197632
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
SKNAS	DepMap CRISPR Gene Dependency	1.0	2.87551
Crizotinib (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192523
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160221
Apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.277
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2812_F8A1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.682751
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.32935
BRD-K03849840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48277
BRD-K61366105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02971
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19713
Ribociclib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226022
PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-863-ZNF830_ZNF830	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97624853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56267
GSE51684,GSE51741_2_v_4_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-46-FO63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597617
POTEI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00397
BRD-A50913845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00094
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00287
Omeprazole_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0119266
A549_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203852
K562_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165872
BRD-K91784140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14236
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201407
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152971
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63957636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01463
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15674
Taproot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
Ascospore wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.988
MCF7_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242191
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220538
BRD-K21784579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30203
HO1U1	DepMap CRISPR Gene Dependency	1.0	2.74563
MCF7_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128125
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163986
BRD-K88448214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37245
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158897
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194919
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349239
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58977
BRD-K03341571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11865
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SNU216	DepMap CRISPR Gene Dependency	1.0	3.09652
937_BUD13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.70669
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526922
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.910187
nBAF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.561
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.324
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113312
RPAIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00592
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277022
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.60137
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607823
RHO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625597
BRD-K19710723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2258
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273301
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210584
BB-62-MS83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277671
npBAF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
Spinal muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198462
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47052171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18319
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6538246-pone.0217497.s007.xlsx-A5SS-ENSG00000196628_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
RH28	DepMap CRISPR Gene Dependency	1.0	3.97671
BRD-K71604365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43431
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
BRD-K49282125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08733
HT1197	DepMap CRISPR Gene Dependency	1.0	4.0763
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_EED226_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170027
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69744558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17354
DNA damage response	GO Biological Process Annotations 2023	1.0	null
Ribonuclease III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.933
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133966
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.732812
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5141
BRD-K06279388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6482
PMC12178937-mmc6.xlsx-D_MAFF_KDvsD_C_deg_all-gene_name_MAFF	Rummagene Transcription Factor Associations 2026	1.0	null
MTOR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586558
A549_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223275
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intracellular immature spore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.959
BRD-K96284156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02884
EA-07-RB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241545
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.7408
BRD-K54622858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5099
Fascioliasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
SLC2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523362
BRD-K60543885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26462
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26306512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33562
BRD-K94476572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00875
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238822
GLB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00356649
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32603
A549_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213567
BRD-K43316594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98246
BRD-K18435317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00414
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526542
BRD-K78119702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60678
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2935
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333512
BRD-K69048559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01552
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.570057
CDC42SE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00358984
BRD-K32925057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95736
MCF7_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192026
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021261
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5029
MCF7_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148521
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207509
BRD-K48880196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12126
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67525
MCF7_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170667
LTBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664613
A549_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148801
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.014298
LO68	DepMap CRISPR Gene Dependency	1.0	3.21418
CRCGN009_HEPG2_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20346
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211427
MCF7_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190885
MCF7_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120478
Abemaciclib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0292924
BE-69-RD44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243751
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96209756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10196
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.556518
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47668
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Meiotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.487
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.27062
BRD-K17122222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07967
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
BRD-K71007902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84409
protein phosphatase regulator activity	GO Molecular Function Annotations 2025	1.0	null
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184953
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202121
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRICKLE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23001
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.95171
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260254
BRD-K58140298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44348
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41843
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48408404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14783
PMC12956708-DataSheet1.xlsx-Supplementary_Table_7-Supplementary_Table_6_The_DEGs_from_high_altitude_between_AMS_and_non-eAMS_group_of_GSE75665_TWIST2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87942399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2631
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08233096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63127
K562_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132399
BRD-K64824710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16264
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Body wall muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9285
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PIO_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168018
MCF7_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159294
MCF7_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255015
BRD-K07540687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31085
BRD-K32949071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07377
MCF7_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014876
BRD-K84792324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25537
MCF7_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0390609
POLR3H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066244
BRD-K58310485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03564
ZMIZ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506228
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61621331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22931
BRD-K89931949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03505
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02903
TUFM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626307
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92359570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61717
RUSC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00690977
protein serine/threonine phosphatase complex	GO Cellular Component Annotations 2023	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.00282
BRD-K18657361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04059
BRD-K44760023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3671
Lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FGFRL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490813
MCF7_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140632
BRD-A03121430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15535
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.8437
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168018
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014312
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58714
TP53-32428506-HUMAN-LIVER-HEPTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.968014
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163754
PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-gene_id_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3500769-srep00875-s3.xls-CEBP-Time_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73695595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68764
GSE110708_2_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
10703_ZNRD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501983
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAK-733_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0414046
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195507
Medroxyprogesterone acetate_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196983
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2098
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09174
BRD-K65789952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00818
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119335
8238_SNW1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03047
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.21798
MCF7_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143686
TLK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00362799
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
CLDND1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523705
BRD-K99413603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46016
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31836496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48432
MCF7_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251934
GSE158834_10_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48727830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3654
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252267
MCF7_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144691
RHOQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45018
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
BRD-K15322427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12577
BRD-K96807219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02148
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15515777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71048
Nuclear speck	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K67783817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12271
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-17-XI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25854
BRD-K77011363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79083
BRD-K65342196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24371
GSE152032_3_v_2_s1pr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
BRD-K67399222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32499
K562_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215921
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181916
EGR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606274
PIGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43576
K562_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195345
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249479
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10857
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129389_0_v_7_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07526417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03065
PMC3607232-mmc1.xls-MLLN_AF4_H3K79me2_RS411-MLL_AF4_H3K79me2_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE212772_0_v_1_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3500769-srep00875-s3.xls-FOXA1-Time_1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A29734477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75913
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33752
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MC1568_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.019122
K562_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157976
BRD-K90965240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47283
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.413
Procainamide (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0212174
MCF7_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213514
BRD-K49530286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40407
MCF7_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01477
TNFRSF13C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059093
2204_DHX16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28527
BRD-A77697958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06921
BRD-K95543908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36907
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213106
BRD-K18179332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43682
BRD-K13941052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36967
Papillary thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05035
Apical cortex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.812
LY2090314_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0246307
PMC9675280-12950_2022_317_MOESM2_ESM.xlsx-LPS_BB-Cl_vs_LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QA-34-BH60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206398
BRD-K61247793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18919
GSE211286_1_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37616496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68391
BRD-K13526564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11745
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-39-ZQ15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218164
SLC18A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00439589
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303198
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00757529
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152488
BRD-K29328556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45566
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26667
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148905
K562_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158285
BRD-K76899562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00442
A549_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222585
BRD-K22633587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06742
protein phosphatase 4 complex	GO Cellular Component Annotations 2023	1.0	null
BICRAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06291
BRD-K18128277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64532
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.596252
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98251998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3525
GSE158834_11_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JJN3	DepMap CRISPR Gene Dependency	1.0	2.42717
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159611
MCF7_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184078
SKNSH	DepMap CRISPR Gene Dependency	1.0	2.69726
Starch grain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.221
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229116
GSE180468_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81623965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4381
OE-78-XD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.606792
BRD-K18178356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62011
GSE111035,GSE111040_3_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195864
K562_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164997
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.957809
FE-61-DL94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52435
Leaf base	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1564
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62184784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33154
ME-16-XW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237261
D283MED	DepMap CRISPR Gene Dependency	1.0	2.98622
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228652
BC-25-VR48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2045
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016362
AB-00-IL62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260524
CRCGN014_HEPG2_3H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12333
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09304381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02538
GSE193258,GSE193259_2_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7834_SF3A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513866
MCF7_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208828
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182219
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A96308662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17519
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K89116076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31224
Spore wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.347
A549_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119351
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JC-02-ZR15_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265744
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35858
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ligustrazine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0211677
MCF7_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140774
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171193
PPIL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553178
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
507_ARL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.538281
NURF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.639
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157518
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4548
BRD-K13673722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18032
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014102
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39087168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55231
SMC loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.562
MCF7_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148234
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Inner kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.719
BRD-K66985689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22544
BRD-K57343972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43679
BRD-K23430405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43485
MCF7_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263854
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168666
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PH-797804_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00802671
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02247
A549_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153404
Nevirapine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00819783
BRD-K55867695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09019
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Protein phosphatase 4 complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K39677043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4363
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.151
A549_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0266645
BRD-K50941200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46066
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K33705415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01857
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155299
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21312826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11574
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168682
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MTA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551899
EW7	DepMap CRISPR Gene Dependency	1.0	3.58792
Lonafarnib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00598652
BRD-K47456612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1267
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261125
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Isw1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.501
BRD-A14098586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61566
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0159
ICAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0034521
MCF7_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151046
KCNQ4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00451248
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_BMS-911543_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119634
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226842
NB-58-SA13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355798
BRD-K46877890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25047
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192797
CUEDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4175
HDAC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514116
BRD-K19183365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06008
BRD-K48207398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31821
BRD-K93662118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44459
BRD-K35491869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69387
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCT15	DepMap CRISPR Gene Dependency	1.0	3.74175
UFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05249
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.66865
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68575551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63401
K562_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198927
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.55084
BRD-K60937893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13101
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6012
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.0655
BRD-K77272277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40227
BRD-K25147028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28684
BRD-K45042519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98938
MAPKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37815
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017161
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.46385
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.673928
TSPAN32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786013
BRD-K66831269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18195
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
MCF7_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151867
MCF7_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187841
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
BRD-K39566424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6466
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145537
K562_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022003
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2549
Female pronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
MCF7_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153185
BF-26-MB27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248548
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477633
BRD-K99978187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01378
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.40032
Bestatin (hydrochloride)_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0156427
BRD-K99100679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.059
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00874657
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05975035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08151
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OV-90 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-92-CZ75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335579
CD-62-GL56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249539
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30053194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47167
Sin3-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.616
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	178.844
HARS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00338831
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
Spliceosomal tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.512
MCF7_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00936765
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205222
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165311
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410128
BRD-K90133770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07846
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.715831
HCC1954	DepMap CRISPR Gene Dependency	1.0	3.03044
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
K562_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129814
MCF7_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175673
Intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159277
CRCGN008_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3506
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMSB4Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18258
BRD-K77832645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06898
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141222
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
WAPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39981
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
t66-lung_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.37818
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.953867
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3278
SKN	DepMap CRISPR Gene Dependency	1.0	2.18467
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124831
Spindle microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.15
BRD-K65266979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1725
BRD-K79204912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00894
GSE203329_0_v_3_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.139
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22595044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16376
EDN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00431665
1972_CWC22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.631976
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.251
Protein phosphatase type 2A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.907
Thoracic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.63945
K562_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166549
BRD-A27407220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21417
A549_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00951451
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202169
Leaf primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.445
t64-ovaries_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.96835
A549_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205433
BRD-K11905754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7664
MCF7_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128822
GSE116299_6_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.92584
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208581
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199606_1_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07486034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01818
BRD-K24271020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40252
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21527
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
protein phosphatase 4 complex	GO Cellular Component Annotations 2025	1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320383
Astral microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.574
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
Doxorubicin (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0247131
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Fasudil_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187952
A549_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237675
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143643,GSE143644_3_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208381
PMC5538547-supp_gr.217331.116_Supplemental_Table_S3.xlsx-DNA_and_CCF-Table_3_Frequency_of_genetic_alterations_determined_from_single-cell_DNA_and_RNA_analysis_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48255349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10499
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215629
BRD-K69960043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54402
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96577
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Viral RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.063
A549_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171227
WD-62-UB45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25487
HT-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.104
K562_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171249
PMC12909836-44318_2025_675_MOESM6_ESM.xlsx-DA_E605_PerS1_M1_10_MQ-noMBR_MR-Unnamed_3_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF823	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2126
BRD-K66733186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10893
MCF7_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167956
A549_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203599
BRD-K19965080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31881
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.23078
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011954
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151391
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13665
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
K562_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153037
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176243
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149483
A549_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139994
BRD-K61651560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30488
GSE176008_4_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79712504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04657
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tranilast_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.010865
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168253
ATOH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05353
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.01197
A549_TMP195_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159698
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134722
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158591
MCF7_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143386
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236693
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.8422
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191745
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04408214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16318
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3254
K562_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021412
3649_HBE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510515
A549_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241859
ZNF627	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01257
BRD-K46742113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71757
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44636
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24628
PH-797804_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0139669
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.5161
INTS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86866
GSE111035,GSE111040_10_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69073616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37502
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98239824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00309
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150602
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4755
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Anaplastic thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
16p11 2 proximal deletion syndrome	WikiPathways Pathways 2024	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.702
MEC1	DepMap CRISPR Gene Dependency	1.0	2.20078
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.5164
Response to selective serotonin reuptake inhibitors in depression	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
MCF7_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198547
K562_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015941
Response To Ssri	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2363
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174316
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76681
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	2.28871
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109456
Fusidic acid_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0220169
A549_Dacinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0101039
MCF7_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137271
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2612
BRD-K55144248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63361
MCF7_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159892
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220133
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24631
K562_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207641
8232_SNRPF_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558969
MCF7_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241804
CEP43	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613859
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02626
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712725
PMC9338313-41467_2022_32034_MOESM4_ESM.xlsx-Heat_shock_HS_60-Table_S1_HSF1-interacting_proteins_enriched_upon_heat_shock_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53797069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01719
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148123
BRD-K84266230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06448
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAPK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00324401
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.3972
A549_Tucidinostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126966
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1769
RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.002
K562_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179169
FKBP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654664
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274552
TEKTIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01651
LCMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17695
BRD-K18515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20736
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188046
BRD-K78755361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03018
BRD-K81447429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40903
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147999
A549_UNC1999_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168217
Hyphal cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.1
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624482
BRD-K69471644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21034
MCF7_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215872
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359934
MCF7_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181639
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.41339
BT12	DepMap CRISPR Gene Dependency	1.0	2.69178
Endosperm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.597
GRB10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00307545
SPATA5L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591129
A549_Danusertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113518
HOXA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00474886
anaphase-promoting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.196
BRD-K83783925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08847
BRD-K99038919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11429
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
Plant primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.159
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.99113
Protein body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
GSE198036,GSE198041_0_v_2_sox9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5	Rummagene Transcription Factor Associations 2026	1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170811
BRD-K55841827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46436
MCF7_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185047
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.74402
K562_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264645
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150129
Meiotic prophase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
PF-06260933_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0246552
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217857
A549_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191852
BRD-K95875837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25391
magnesium-dependent protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.264
BRD-K77024507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25566
HEC6_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.48063
A549_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141316
BRD-K94582694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62681
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gravid adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.698
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7354
QC-12-DW06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213634
GSE102187_0_v_1_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137512
TNS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07148
MCF7_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013357
MCF7_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212076
A549_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201102
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SBC5_LUNG	CCLE Cell Line Proteomics	1.0	2.81702
A549_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195595
BRD-K27221973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04572
BRD-K49391713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02474
BRD-K95192796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00166
K562_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167321
GSE220668_0_v_1_ncapg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224268
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64055457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35344
Nuclear speckles	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271575
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241347
BRD-K63960902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05459
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24377650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40702
MCF7_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203019
MCF7_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215159
BRD-K01853388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00548
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120033
BRD-K22380647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07309
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226802
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MK-3903_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231036
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-ensembl_gene_id_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53456628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00741
BRD-K92349794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37813
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172416
BRD-K88977610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10959
OTS514_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0257461
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TTC39A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643114
BRD-K87264606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05255
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166032
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30628
GLS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0113534
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183716
APBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45837
MCF7_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143006
UCHL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28438
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178394
Digitoxin_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0343893
HCC44_LUNG	CCLE Cell Line Proteomics	1.0	2.22646
PLAAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26361
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214706
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_37_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148831
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Ruxolitinib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.023022
MCF7_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198902
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21119095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21084
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222458
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09177
Ndc80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.904
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-T_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Petiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
A549_Azacitidine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108449
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216899
WAOSEL	DepMap CRISPR Gene Dependency	1.0	2.95421
A549_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130264
SE-81-RI20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25223
PHLDA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654644
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130673
MCF7_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160461
MS4A18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681032
EAPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46799
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CC-49-CQ25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207149
BRD-K85851814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30388
BRD-K51927648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04542
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177348
RPL37A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0114627
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73904
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218519
A549_SRT2104_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157411
HEC59	DepMap CRISPR Gene Dependency	1.0	3.51116
ART3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583188
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160402
KIFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09269
BRD-K77892726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42742
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEP170	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104201
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Coleoptile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.05
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
IC-98-UO17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278422
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506512
K562_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183545
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32992
A549_Ofloxacin_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131895
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.935088
Glucagon signaling pathway	KEGG Pathways 2026	1.0	null
GUCY2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00809217
EIF3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37033
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138571
Nevirapine_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0262696
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4834
MCF7_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190277
PH-797804_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0182195
TE-87-FM14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517649
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00985869
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010703
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23430114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08196
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31274
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241536
BRD-K61144709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06721
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82538319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70358
MCF7_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131031
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159501
Ouabain (Octahydrate)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0111112
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05698
RZZ complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.301
UCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00687819
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220324
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
SVGp12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
BRD-K22720379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95763
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22321
PDE1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00455986
BRD-K42392619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10819
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180986
A549_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178488
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222821
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K42034238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36689
BRD-K92640680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02661
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106261
UBA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640376
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
BRD-K11782435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3949
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50056
NCIH1792_LUNG	CCLE Cell Line Proteomics	1.0	2.20354
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125372
BRD-K40418847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13451
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486776
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
GSE241031_0_v_4_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180322
DMRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21948
PTRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19992
PMC3369932-pgen.1002751.s026.pdf-26-CSDA_YBX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
protein phosphatase regulator activity	GO Molecular Function Annotations 2023	1.0	null
Breast cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNA damage response	GO Biological Process Annotations 2025	1.0	null
BRD-K90808566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11721
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.784554
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512704
BRD-K52300725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13896
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63756
BRD-K59030325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79756
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40518
MCF7_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134545
Nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.441
BRD-K29178949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51092
Artery	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023392
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K04710685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00606
BRD-K37282009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18428
BRD-K86036680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91313
CSTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32606
1972_CWC22_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16309
KCNMA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492184
SHISA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682064
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neuroblastoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K79199168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45215
AA-67-TF79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257673
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177034
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121483
PH-797804_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0155945
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
TC-66-CI47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600626
Neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.355
SDHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83591
GSE231648_0_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pericarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.347
K562_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223409
SCN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725728
A549_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140901
post-spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.733
K562_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189123
GSE110708_0_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
fungal-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.204
Vegetative cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.824
B-CPAP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177416
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166504
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209206
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027464
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200392
Tirabrutinib (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222187
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128754
A549_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195484
HGC27_STOMACH	CCLE Cell Line Proteomics	1.0	2.41623
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K46701848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64545
Stipule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
NMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68257
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.912545
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320773
D458	DepMap CRISPR Gene Dependency	1.0	2.16036
BRD-K87447060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04781
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110708_1_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327217
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456595
BRD-K57274378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79
Pentoxifylline_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0298903
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SCIMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00721481
Proportion of activated microglia (inferior temporal cortex)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
GSU	DepMap CRISPR Gene Dependency	1.0	2.93687
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148168
BRD-K50081142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10767
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_23-ZFX_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Aurora A Inhibitor I_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170101
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RPL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00929746
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196305
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9226_TRAF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598207
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209298
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52845
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62455
PNCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572806
DAPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452282
esBAF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542394
ALOX12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489535
GF-46-LK68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235564
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0387
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04391
BRD-K73182084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46083
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194765
BRD-K76921877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15205
BRD-K86792405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17107
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2015
BRD-K55142307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02718
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41274
BRD-K77535986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38505
Nuclear dicing body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.925
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194275
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SMPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01344
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04525
Indacaterol (maleate)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.031627
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16801
PMC5985538-mmc2.xlsx-Selected_2X_in_2_exp_SALL1_275-Gene_names_SALL1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012449
IL36RN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618778
Perindopril (erbumine)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0159274
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.6176
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182435
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230378
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.607834
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
MCF7_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322097
SLC35A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03591
gamma-tubulin large complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
ALPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557906
CRCGN014_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10925
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.074
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142221
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE62843,GSE64370_0_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB1	DepMap CRISPR Gene Dependency	1.0	3.8631
MCF7_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152552
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEACAM8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500979
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Midbody	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.988
BRD-K58498516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45719
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199927
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143155
NKX6-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40112
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0109144
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	171.598
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125822
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
wc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
Hyphal tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.01
DSIF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.665
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PHA-680632_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232958
RPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3174
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MM160113	DepMap CRISPR Gene Dependency	1.0	3.36644
GJB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500935
BRD-K93260425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19825
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K46890865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28521
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K07276022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30606
GTEx Uterus 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	3.77036
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249598
A549_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307161
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K48994888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04783
Plant cuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29895
PGA1	DepMap CRISPR Gene Dependency	1.0	2.41383
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016836
BRD-K12959846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61707
RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65353
BRD-K69038251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43492
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419932
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.399
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43375231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46669
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134375
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.04525
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0284786
PMC6538246-pone.0217497.s007.xlsx-A5SS-TCF4_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192287
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dorsal lip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
YAMATO	DepMap CRISPR Gene Dependency	1.0	2.47394
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23372
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8875
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06685815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16963
A549_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155134
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9314667-Table_1.xlsx-Regulons-TFAP2A_TFAP2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3060339-emmm0003-0089-SD1.pdf-46-ETS1_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21180458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09041
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26529
ABCB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66502
BRD-K72533381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10649
BRD-K50146114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68669
FURIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19953
A549_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00902234
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180535
NCIH446	DepMap CRISPR Gene Dependency	1.0	3.8891
Pituitary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.25909
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6035
MCF7_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237603
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273859
957_C11ORF74_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52104
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.624975
BRD-K54007898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33668
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158573
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142346
IE-02-TR35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318981
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TM6SF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496165
PMC4021518-bjc2014169x4.xls-MITF_targets-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
8500_STAT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575079
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16919
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137629
HMGB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16101
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28561
GSE234334,GSE234336_1_v_0_zhx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTMR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05343
SKMEL19	DepMap CRISPR Gene Dependency	1.0	2.37781
A549_Ellagic acid_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187173
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.6548
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170853
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212511
protein phosphatase activator activity	GO Molecular Function Annotations 2023	1.0	null
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8888_THOC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46778
IEC-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173619
A549_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014694
PMC10350077-media-8.xlsx-Controls_LPS_enriched_Down_KEGG-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SLC38A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32211
SPNS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525845
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168738
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.42873
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.63464
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143819
7185_RBM8A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12538
MCF7_Patupilone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130066
SW48	DepMap CRISPR Gene Dependency	1.0	2.70969
BRD-K52310606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57729
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Minodronic acid_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.030577
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WF-85-JN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256875
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149583
MCF7_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143637
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
BRD-K62807053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23326
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11415
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.985126
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CSF1-CSF1R complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.713
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.09128
Mo-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
K562_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215071
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28815
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285542
AC-98-QW77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20936
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DRD5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691616
ZFP36L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657783
Panicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.0375
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
WC-89-JT40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.848887
FLO1	DepMap CRISPR Gene Dependency	1.0	2.60814
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157921
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEPCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08606
GSE149035_7_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.947824
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32875
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
TREML1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553472
Intrinsic component of synaptic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Terfenadine_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0229036
RPL22L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519018
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
MRGPRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23693