association dataset threshold value standardized value tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.70355 Skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 3-nitropropionic acid-6367 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DUSP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19107 MCF12A Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.811851 Arrhythmogenic Right Ventricular Dysplasia DisGeNET Gene-Disease Associations 1.0 null BRD-K91148820 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32304 clindamycin-1373 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Endometrial Adenocarcinoma DisGeNET Gene-Disease Associations 1.0 null CROT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00544407 Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055394 Pain DisGeNET Gene-Phenotype Associations 1.0 null LY-294002-6175 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K34369474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54869 FLO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null LIN7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22085 cyclopenthiazide-4229 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.864894 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947202 doxycycline-2737 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K50830147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32277 BRD-K44307624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81261 BRD-K20836550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18884 MYOZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59066 chlorprothixene-2627 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PRKAG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18095 ZNF471 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49761 NCIH650 CCLE Cell Line Gene CNV Profiles 1.0 2.06023 BRD-K05002317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32043 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 PLEKHG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35389 BRD-K44078665 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79375 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053589 GTF2A1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25113 BRD-K15833017 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77428 Neoplasm Metastasis DisGeNET Gene-Phenotype Associations 1.0 null streptomycin-3195 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC8187902__F3 PFOCR Pathway Figure Associations 2024 1.0 null DIABLO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2478 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21098 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.867851 SYNGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86415 NCIH1876 CCLE Cell Line Gene Expression Profiles -1.0 -1.46205 ZNF821 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92802 Acute Myeloid Leukemia_LAML_TCGA-AB-3011-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59966 peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833657 HMCB CCLE Cell Line Gene Expression Profiles 1.0 2.3492 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04468899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35776 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.94719 BRD-K55220938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0076 CTSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67338 cotinine-5246 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TRIM32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23718 fusidic acid-6754 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NB17 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K65432867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07723 BRD-K05070188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5093 HDQP1 CCLE Cell Line Gene CNV Profiles 1.0 1.35437 FAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97908 hydrochlorothiazide-4970 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null demeclocycline-2545 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null leflunomide-6102 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IALM CCLE Cell Line Gene CNV Profiles 1.0 3.2803 triamcinolone-2078 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7681-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K87995704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23519 FU97 COSMIC Cell Line Gene Mutation Profiles 1.0 null LS-1034 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K50068274 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96345 Whole Blood GTEx Tissue Gene Expression Profiles 2023 1.0 3.42497 Periodontal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.121 BRD-K35646839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04194 ZBTB7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89965 SPI1 ENCODE Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A855-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EDARADD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95107 cellular_component GO Cellular Component Annotations 2015 1.0 null SLC25A39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15243 SH10TC CCLE Cell Line Gene CNV Profiles 1.0 1.52851 BRD-A64761364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67573 BRD-K60132279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10761 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27387 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.25373 lingual gyrus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0982 retinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.218034 sulfadimidine-2560 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K78866630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04551 SNU-283 COSMIC Cell Line Gene Mutation Profiles 1.0 null TPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25222 JUND-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NAGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98583 MYCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25429 BRD-K31778735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1534 Prestwick-1085-6131 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF248 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61044 geldanamycin-593 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GI-ME-N COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF286A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49656 cimetidine-1884 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K95129711 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00993 HELA BioGPS Cell Line Gene Expression Profiles -1.0 -1.30182 HCC1954 CCLE Cell Line Gene CNV Profiles -1.0 -1.643 PMC6599263-13073_2019_654_MOESM2_ESM.xlsx-CAR1_tsv-gene_name_NR1I3 Rummagene Transcription Factor Associations 2026 1.0 null benzbromarone-5015 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K50479239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6819 BRD-K41887762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01814 TRA2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77489 NCIH2073 CCLE Cell Line Gene CNV Profiles -1.0 -1.63186 BRD-K50066702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34996 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null HINT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80654 ZBTB33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66627 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13785 C1orf35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33945 MCF7 CCLE Cell Line Gene CNV Profiles -1.0 -1.67212 Acute Myeloid Leukemia_LAML_TCGA-AB-2807-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null angular gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.905388 cetirizine-2468 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null capsaicin-4612 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH196 CCLE Cell Line Gene CNV Profiles -1.0 -1.88243 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31043 PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K22949587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10404 Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null famprofazone-3753 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16364 GPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45414 HLE COSMIC Cell Line Gene Mutation Profiles 1.0 null SJSA-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K06492501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37533 guanfacine-5256 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.05289 PRR14L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0037507 PRELID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11171 florfenicol-3083 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Childhood Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6U6-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TSHZ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83656 BRD-K75625428 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21684 lateral group of nuclei, right, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.894477 beta-escin-6050 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null isoxicam-1698 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K91577886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.40766 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 skin GTEx Tissue Gene Expression Profiles 1.0 1.61342 BRD-K68858233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45157 midodrine-1403 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Obesity DisGeNET Gene-Disease Associations 1.0 null NCIH2172 CCLE Cell Line Gene Expression Profiles 1.0 1.9662 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0173 clorgiline-5005 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CCDC174 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35117 lovastatin-2494 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27389 ERI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.61342 PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-FOS-HIT_FOS Rummagene Transcription Factor Associations 2026 1.0 null YMB1 CCLE Cell Line Gene CNV Profiles 1.0 1.34159 ZNF503 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98105 medrysone-3705 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02778241 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16672 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nalidixic acid-2297 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K96758498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61697 Presbyopia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.584 proline-rich Phosphosite Textmining Biological Term Annotations 1.0 null TMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2984 HCC366 CCLE Cell Line Gene Expression Profiles 1.0 1.47068 BRD-K26603007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25131 PRMT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66408 NRXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56113 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.46922 BOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95923 AKIRIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23497 luteolin-5004 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CCDC86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22626 KLHL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41525 Pneumonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.087 dobutamine-6286 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MMRN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00503187 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.872406 Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus subceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.73902 BRD-K23598860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22944 sulpiride-4566 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853076 natamycin-5809 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ABCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57807 cingulate gyrus, parietal part, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.824409 BRD-K73442516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94565 BRD-K88494268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62695 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46681 SP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05023 DMS-53 COSMIC Cell Line Gene Mutation Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K51335814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17581 HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -0.93879 Acute Myeloid Leukemia_LAML_TCGA-AB-2993-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 SLC25A28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36692 BRD-K87269010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21275 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00209 BRD-K42785890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56095 tobramycin-4162 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COV434 CCLE Cell Line Gene Expression Profiles 1.0 1.92383 BRD-K54420800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19179 BRD-K54925224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21636 PRKCI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79979 PDILT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00676514 amiloride-1470 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K69437108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49526 TSPAN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06693 MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.897661 haloperidol-418 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TCF21-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K79937734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03085 GOLGA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82395 HEC108 CCLE Cell Line Gene Expression Profiles -1.0 -1.71542 Polyps DisGeNET Gene-Phenotype Associations 1.0 null CHL1 CCLE Cell Line Gene Expression Profiles 1.0 3.40797 MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03888 TRAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81448 staurosporine-508 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null SYNE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83122 AR-19668381-PC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNG1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33167 cyproheptadine-6740 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTPN18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29775 BRD-K78642007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07359 Mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.124 FUBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87164 cefixime-3247 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K96779993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49026 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EI-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-7519-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52298 occipito-temporal gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.825059 L3MBTL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72269 METRNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11368 Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.156 PLCXD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25405 sulfathiazole-4769 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prestwick-665-6041 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K86159732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28857 piromidic acid-3335 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UBE3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28077 Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ORAI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58996 BRD-K28294686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65743 inner SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16961 MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.759575 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.369 cefoxitin-2735 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Hypertrophic Obstructive Cardiomyopathy DisGeNET Gene-Disease Associations 1.0 null nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039677 MRPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63904 BRD-K45013233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67967 organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 cingulate gyrus, retrosplenial part, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09498 meclozine-5244 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22544 BRD-K30821056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28334 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBFOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79902 NEUROG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44755 PPP2R2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20969 dexverapamil-164 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K30895360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.56058 BRD-K72125659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46303 vancomycin-2858 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null betonicine-3745 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hesperetin-6750 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null amikacin-3233 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24122 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053982 blebbistatin-837 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUMO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89857 Brain Lower Grade Glioma_LGG_TCGA-HT-7877-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K86988191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24003 ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00725 bupivacaine-5537 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ChIP_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80K-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancytopenia DisGeNET Gene-Disease Associations 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null droperidol-4629 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.79698 corbadrine-7208 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ocular cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.442418 EPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99321 BRD-K97934318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7302 BRD-K50053371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19567 LIMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24428 HTT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03549 PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_Ref_Can-KLF16_KLF16 Rummagene Transcription Factor Associations 2026 1.0 null LC1SQSF CCLE Cell Line Gene Expression Profiles 1.0 1.39673 diloxanide-5025 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IFNAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30471 Primary Myelofibrosis DisGeNET Gene-Disease Associations 1.0 null bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.988749 BRD-K35469110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55694 SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16354 NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16648 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33979 molecular_function GO Molecular Function Annotations 2015 1.0 null BRD-K85622666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62109 TGFBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82818 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853076 BRD-K71590663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37618 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TTC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43999 Premenstrual Symptom DisGeNET Gene-Phenotype Associations 1.0 null extracellular region LOCATE Curated Protein Localization Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5740-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K86373784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08841 naftidrofuryl-1267 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH146 CCLE Cell Line Gene CNV Profiles 1.0 2.59998 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.837782 SENP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5584 valproic acid-1181 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tribenoside-6328 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61513 UMPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76695 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV2-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K01627964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09551 184A1N4 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.15711 BRD-K17514980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53031 estropipate-6808 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null coralyne-1298 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_12959_KD_YTHDC1_SRP309987 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.27464 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.94845 MEWO CCLE Cell Line Gene CNV Profiles -1.0 -1.42533 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089893 CLDN23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76884 BRD-K09250647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07596 doxazosin-4988 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K97493608 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12394 LARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30735 lobeline-1770 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tanespimycin-505 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ATP1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26008 methapyrilene-4990 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K22974051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05212 flunarizine-7013 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPSM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72494 Acute Panmyelosis With Myelofibrosis DisGeNET Gene-Disease Associations 1.0 null gossypol-6058 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41143 fenoterol-5432 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GDM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.51443 Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.116885 outer CP in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932236 Central Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null oxymetazoline-1431 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.932362 PAWR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13426 TOLEDO CCLE Cell Line Gene Expression Profiles -1.0 -1.5385 Proline-rich protein InterPro Predicted Protein Domain Annotations 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25973 Cancer of the testis_Testis_GSE1818 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.82586 HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00705 THEM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88385 MED25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19443 Prestwick-674-6034 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COL1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97412 MARCHF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1057 BRD-K41271559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48212 Seasonal Affective Disorder DisGeNET Gene-Disease Associations 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.468 BRD-K57938735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40795 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC25A15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00560391 BT-483 COSMIC Cell Line Gene Mutation Profiles 1.0 null fulvestrant-1205 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null clobetasol-6095 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70518 Multiple Sclerosis DisGeNET Gene-Disease Associations 1.0 null NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07108 BRD-K69613314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.39687 moxonidine-2923 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Coronavirus infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13896 WM983B CCLE Cell Line Gene Expression Profiles 1.0 2.20153 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.872406 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CH-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K47754225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23446 ANKRD34B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36296 8-azaguanine-1670 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09305 NCIH1666 CCLE Cell Line Gene CNV Profiles -1.0 -2.11386 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-96-7544-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66904 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.878414 BRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38033 PREP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98091 HUCCT1 COSMIC Cell Line Gene Mutation Profiles 1.0 null ranitidine-6324 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null OAW28 CCLE Cell Line Gene Expression Profiles 1.0 1.98586 HH CCLE Cell Line Gene CNV Profiles 1.0 1.51242 norcyclobenzaprine-2469 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80735 HCC2814 CCLE Cell Line Gene CNV Profiles 1.0 1.69741 RAB5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92439 INO80E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97589 CILK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.82461 ergocalciferol-6746 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2975-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-12q13_11_TP63 Rummagene Transcription Factor Associations 2026 1.0 null valproic acid-6173 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PARD6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76956 terazosin-5831 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K52259096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40358 Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.293 HSD17B10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86083 NEURL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86636 benfluorex-2621 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.359 MTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5489 RAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64315 raloxifene-388 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K82224868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63047 NEU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5921 AXIN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00454169 TBX22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00308 riluzole-2334 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08427390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48862 benperidol-4196 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K89933563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06502 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52298 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Premenstrual Dysphoric Disorder DisGeNET Gene-Disease Associations 1.0 null Myelofibrosis DisGeNET Gene-Disease Associations 1.0 null PMC2753593-1755-8794-2-59-S4.xls-SuppFile2-IRF8_IRF8 Rummagene Transcription Factor Associations 2026 1.0 null DU145 BioGPS Cell Line Gene Expression Profiles 1.0 0.927045 TUBB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77131 GARRE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81802 tanespimycin-1218 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1395 COSMIC Cell Line Gene Mutation Profiles 1.0 null USP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0381 NAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22726 hsa-miR-579 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.405 BRD-K15160749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.59101 BRD-K24004917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0859 Acute Myeloid Leukemia_LAML_TCGA-AB-2983-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K20030272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21655 metacycline-4062 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27387 BRD-K84745303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24663 BRD-K10027041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42133 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16402 BRD-K21996934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52695 citiolone-6031 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K98938484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41177 SUDHL1 CCLE Cell Line Gene CNV Profiles 1.0 1.53087 Prostate adenocarcinoma_PRAD_TCGA-KK-A8I8-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intercalated nucleus of amygdala Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.97062 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34978 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.862787 COLO792 CCLE Cell Line Gene Expression Profiles 1.0 1.55157 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null pyrithyldione-2740 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08607520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59422 VOPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23298 TOE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45118 MD MB231 BioGPS Cell Line Gene Expression Profiles 1.0 1.02865 Autoimmune disease of musculoskeletal system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 skimmianine-2504 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTF2I CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04458 diphenhydramine-7318 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null metformin-2 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.51831 ZSWIM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46811 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null MPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03693 BRD-K78432272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02644 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.944501 phensuximide-5522 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041884 BRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38577 Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32520360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13931 ranitidine-2251 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K50710722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92202 pipenzolate bromide-6821 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.838884 COV362 CCLE Cell Line Gene Expression Profiles 1.0 1.79778 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00705 meclofenamic acid-2291 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K28351377 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80048 JPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21551 nafcillin-4103 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null estropipate-6068 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FAM83E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85374 retinoblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.446935 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Progressive Multiple Sclerosis DisGeNET Gene-Disease Associations 1.0 null Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.069 SLC24A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41991 BRD-K98343273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10365 OPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53061 BRD-K95768123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56825 SOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99377 fenspiride-2269 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null arachidonyltrifluoromethane-594 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MACO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24527 C11orf86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45681 carisoprodol-4955 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CFPAC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null arsenic trioxide_homo sapiens_gpl201_gse48441 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC6787451__F6 PFOCR Pathway Figure Associations 2024 1.0 null DDX27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76455 ECC12 CCLE Cell Line Gene Expression Profiles -1.0 -1.60974 retrorsine-2129 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null SFRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60063 Thrombocytosis DisGeNET Gene-Disease Associations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5487 ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10583 SkeletalMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.24228 BRD-K23342427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09817 SU-DHL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16964 Sarcoma_SARC_TCGA-PC-A5DN-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K53619784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4419 prednisolone_homo sapiens_gpl570_gse32962 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06537903 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08534 BRD-K03262163 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03002 DHX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98672 PIK3R3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05113 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71055 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.976875 alprostadil-4179 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K71893034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06612 leaf disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.49726 BRD-K15654812 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64701 STX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52375 PLCB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67041 NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.71932 BRD-K22508525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05705 BRD-K92725027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8859 Nerve Entrapment DisGeNET Gene-Disease Associations 1.0 null BRD-K12524155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17997 NCI-H522 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K63008302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17006 flucloxacillin-5102 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Thalamus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.20317 BRD-K40318276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23444 PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A Rummagene Transcription Factor Associations 2026 1.0 null CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 1.72699 BRD-K86025005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12342 SH4 CCLE Cell Line Gene CNV Profiles 1.0 1.3827 BRD-K35196805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46465 BRD-K87340219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31154 BRD-K21582416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23781 DTX3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84199 pheneticillin-6105 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K67716105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21272 BRD-K00243272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38877 pheniramine-1910 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null canavanine-2141 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K24502602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76339 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.66349 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057059 EB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.77428 sulfacetamide-6349 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null streptozocin-6098 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null norfloxacin-7283 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.99271 shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.08079 C2CD4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.44748 JMJD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20828 BRD-K56884305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24206 BRD-K24471810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05731 ZNF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54565 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46D-01A-21R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null santonin-3877 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3007-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ketoconazole-2640 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DNASE2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70778 JHH4 CCLE Cell Line Gene Expression Profiles -1.0 -1.66459 BRD-K71216961 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34626 Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BTBD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42798 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15767 Alzheimer Disease DisGeNET Gene-Disease Associations 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.851132 BRD-K42145213 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28559 HMGXB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66907 RHPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76349 LCLC97TM1 CCLE Cell Line Gene CNV Profiles 1.0 1.96065 MARK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04578 Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.047 SMCO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70044 PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null chlorzoxazone-2100 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4639-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 SUDHL4 CCLE Cell Line Gene CNV Profiles 1.0 1.6726 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16316 RPMI-8226 COSMIC Cell Line Gene Mutation Profiles 1.0 null TSPAN7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00647587 22RV1 CCLE Cell Line Gene Expression Profiles -1.0 -1.81129 rolitetracycline-3031 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CD14+_Monocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.12533 CD151 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07706 BRD-K95591068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70455 VPS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47307 TMEM121B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98126 PGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00628 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.19208 trichostatin A-448 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUN-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28943 BRD-K64698855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00432 carbenoxolone-4173 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Silicosis DisGeNET Gene-Disease Associations 1.0 null BRD-K64840743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40966 fluorocurarine-6083 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02535446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09477 BRD-K49328571_dasatinib_MCF7_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ARMCX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06714 BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.549683 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40877 BRD-K71755682 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38895 IPO7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99898 DKMG CCLE Cell Line Gene Expression Profiles 1.0 2.05878 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03213 YDJC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00508642 BRD-K28314528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46281 cerebellar vermis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899775 TACO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50149 UBTFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22889 nitrendipine-3087 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null metamizole sodium-6030 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AIMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2995 BRD-K42776812 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4911 Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null ARL5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03287 HS746T CCLE Cell Line Gene CNV Profiles 1.0 1.46356 BRD-A17687311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32222 caudal putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15349 Inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 Myeloproliferative Neoplasm, Unclassifiable DisGeNET Gene-Disease Associations 1.0 null GPX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52893 ethotoin-4545 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null OVCAR8 CCLE Cell Line Gene Expression Profiles 1.0 1.52774 BCAP29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59896 FGA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0044796 BRD-K77399094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.59116 PMC11732233-mmc1.pdf-24-PRDM2_PRDM2 Rummagene Transcription Factor Associations 2026 1.0 null ampyrone-1402 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null arachidonyltrifluoromethane-327 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.75742 Bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 BRD-K33016067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05917 MAFF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00602721 BRD-K30792491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09024 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42625 TRIM21 Hub Proteins Protein-Protein Interactions 1.0 null Acute Leukemia DisGeNET Gene-Disease Associations 1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55968 BRD-K43364707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74479 TMEM70 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.678 CYB5RL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39249 BACE1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00503268 heliotrine-4277 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51951 WDR44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66119 SLC19A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00480809 lomefloxacin-3723 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null APAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.57162 SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A25993094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19521 BRD-K28512751 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55842 SUP-HD1 COSMIC Cell Line Gene Mutation Profiles 1.0 null alfuzosin-5242 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40993 Kidney Chromophobe_KICH_TCGA-KO-8414-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K23553911 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86063 BRD-K29652917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11605 alimemazine-2736 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8430-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BICD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95359 AIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97073 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.312232 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.16921 phentolamine-3971 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null small intestine GTEx Tissue Gene Expression Profiles -1.0 -1.38022 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.381 ZNF570 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58983 BRD-K60175505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03523 icSARS CoV_72Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.70111 AMOTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38377 SNX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75372 MEC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.33041 BRD-K25757432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3974 etofenamate-3989 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null transverse gyri, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.928748 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925196 ERCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60649 layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29926 BRD-K69241192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15358 HT55 COSMIC Cell Line Gene Mutation Profiles 1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.965372 CITED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64327 deferoxamine-3760 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI H23 BioGPS Cell Line Gene Expression Profiles 1.0 0.91086 ipratropium bromide-5823 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GLRX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00559355 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.853184 lobelanidine-5500 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59966 fenoprofen-4274 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pleural mesothelioma WikiPathways Pathways 2024 1.0 null BRD-K38519440 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14518 BRD-K88385836 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04864 procainamide-2618 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null picotamide-2233 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K75981085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28511 tretinoin-447 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K61807670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04001 PMC3463457__F1 PFOCR Pathway Figure Associations 2024 1.0 null BRD-K36730085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24082 BRD-K15739647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27648 BRD-K44760023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34327 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.059851 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.269567 DU145 CCLE Cell Line Gene Expression Profiles -1.0 -1.46406 SQ1 CCLE Cell Line Gene CNV Profiles 1.0 1.57759 mesalazine-124 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null iloprost-496 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41184 layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32663 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83V-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72317601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14817 NKX2-3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80208 seedling TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.34371 SKIL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00701257 PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6624 BRD-A23340824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62402 Acute Myeloid Leukemia_LAML_TCGA-AB-2839-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K83143868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13997 BRD-K28924192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0466 SCRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83542 12384550-Table3 GeneSigDB Published Gene Signatures 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58793 rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.311932 HARBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55987 BRD-K15931098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45247 Propylthiouracil CTD Gene-Chemical Interactions 1.0 null retinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.446558 bucladesine-2741 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K85441584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13346 TMEM183A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51833 PDHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81637 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31203610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11736 BRD-K14970242 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14766 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39356 fulvestrant-704 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K94962942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26129 BRD-K47690679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49997 cingulate gyrus, parietal part, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10648 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sulfametoxydiazine-2712 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -0.937656 NFE2L2_01_60 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.47081 salivary gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CNOT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88225 CHMP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5238 ZNF709 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50795 BRD-K79635719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11449 Prestwick-857-4980 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K42457027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25181 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.02775 TWF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50391 OTUD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06923 BRD-K63997411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12985 BRD-K03093950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71711 Retinoblastoma DisGeNET Gene-Disease Associations 1.0 null mianserin-6260 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.081625 ATP6V1E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07875 TMK-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.99409 ZNF609 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52911 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0915 physostigmine-6226 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.477 Gout DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 probucol-3223 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K12708839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00836 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.2337 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13785 meticrane-1792 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06237859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33 Iron Overload DisGeNET Gene-Disease Associations 1.0 null hydralazine-3724 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K97798118 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30164 Acute Myeloid Leukemia_LAML_TCGA-AB-2954-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null quinisocaine-4207 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Trachea BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.73905 SOBP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0049113 DPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98231 ANGEL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56338 SUIT2 CCLE Cell Line Gene CNV Profiles 1.0 1.90772 MPZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65865 15-delta prostaglandin J2-446 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Blood Spots DisGeNET Gene-Disease Associations 1.0 null Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.158 BRD-K48235533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09114 NUGC2 CCLE Cell Line Gene CNV Profiles 1.0 1.5348 calcium pantothenate-1311 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null salsolidin-4810 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72156149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43911 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.117 MOLM6 CCLE Cell Line Gene Expression Profiles -1.0 -1.6151 ZNF212 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75776 PPIP5K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50307 salbutamol-3677 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TE-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null THP1 CCLE Cell Line Gene CNV Profiles -1.0 -1.65646 AIDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34547 DLGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43227 HCC2279 CCLE Cell Line Gene CNV Profiles 1.0 1.64706 tropicamide-3722 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cortisone-2385 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K83895653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1614 celecoxib-377 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null alclometasone-6229 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K58586013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31119 mepenzolate bromide-6024 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.09715 HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12724 NANOG-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K52685199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06044 substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23938 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039968 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27389 Thrombocythemia, Essential DisGeNET Gene-Disease Associations 1.0 null camptothecin-2321 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CXXC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30564 DMRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79667 ramipril-6150 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16609 KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null TMEM230 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.39134 CYB5R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42631 Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acenocoumarol-7232 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KMRC-20 COSMIC Cell Line Gene Mutation Profiles 1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24122 hexestrol-2515 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7820-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTSH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52113 SP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41998 BRD-K48372955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32866 flavoxate-6326 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null epirizole-7292 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null diclofenac-445 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K74150320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37378 HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.722984 putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30632 BRD-K65789952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19265 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35882 BRD-K00804254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22586 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null wortmannin-506 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K28258038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38985 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27498 naloxone-2006 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null monastrol-596 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KCTD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69071 PCDHB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55891 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050893 TRIM16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13609 iodixanol-3362 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K97707303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25212 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3R5-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.912937 GYS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81237 CHST1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00408346 Dentine erosion DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.24 BRD-K44309337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58783 HLX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98542 bufexamac-5090 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HT1197 CCLE Cell Line Gene Expression Profiles 1.0 1.57251 MRPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32265 extrinsic component of cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.556387 NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.592845 BRD-K64992851 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29679 pronetalol-2902 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null acacetin-4324 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ANKRD54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69776 PMC6787451__F6 PFOCR Pathway Figure Associations 2023 1.0 null carbamazepine-1683 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null deptropine-6523 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF135 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89956 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3205 dextromethorphan-5401 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DUT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52515 F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14268 repaglinide-7216 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ECE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66715 POLR2A ENCODE Transcription Factor Targets 1.0 null RASA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47658 ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.999539 glibenclamide-7202 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZFYVE19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75053 tanespimycin-5586 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K64329997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54883 rotenone-5943 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FAM117A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42889 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.48368 body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.94391 BRD-K37014934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31497 LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974288 sulfamerazine-6036 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.09005 TRNP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1317 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.71976 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48683 H-7-5936 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.10972 BRD-K73001304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50639 SYDE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18305 Adrenocortical carcinoma_ACC_TCGA-OR-A5LB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041903 Dental caries DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 cuneus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17091 LRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58624 BRD-K83670600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04528 biological_process GO Biological Process Annotations 2015 1.0 null etiocholanolone-3742 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SIDT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00646514 Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 RCBTB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49272 tubocurarine chloride-5449 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BEX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01618 medrysone-2544 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BYSL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00498852 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885585 DAB2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52695 MMS19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05468 TOMM20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82734 SUDHL6 CCLE Cell Line Gene CNV Profiles -1.0 -1.43267 lisuride-5028 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pentolonium-3676 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null valproic acid_homo sapiens_gpl96_gds1050 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055202 sodium phenylbutyrate-363 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K94637240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6735 ATP6V0E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10357 ARFIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23625 PRR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22388 Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POTEI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90059 pirinixic acid-487 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SKMEL1 CCLE Cell Line Gene CNV Profiles 1.0 1.63753 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hypocotyl TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.374618 Neuroticism DisGeNET Gene-Disease Associations 1.0 null 6-bromoindirubin-3'-oxime-7048 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAS2R5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88722 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.5226 BRD-K24719325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30001 BTG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80699 ozagrel-7281 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7044-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85546819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27823 LC1F CCLE Cell Line Gene Expression Profiles 1.0 1.44626 BRD-K34721572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15904 BRD-K29756429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85685 BRD-K19411393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32586 BRD-K66179451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20117 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4686 lateral parabrachial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.0826 brinzolamide-3230 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null merbromin-2577 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02844551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40837 ACOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06413 Gingival disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.26374 Clinically Isolated Syndrome DisGeNET Gene-Disease Associations 1.0 null fenoprofen-2553 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4798 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mefloquine-6205 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null retrorsine-4946 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 NCIH841 CCLE Cell Line Gene Expression Profiles -1.0 -1.67069 cytoplasmic side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.556387 PDHA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41955 BRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55349 ARL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33745 butamben-6093 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DLGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18473 FABP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78243 BRD-K68916730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52302 pirlindole-3140 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K77119472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22166 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.294 metformin-4 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47401 Hypomyelinating leukodystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 PAX2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K37865727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07906 BRD-K53896147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78629 nialamide-3790 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K67665252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61575 GPANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34049 tanespimycin-221 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TMEM167A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56988 ethanol_homo sapiens_gpl96_gds2767 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92628 WARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7417 Brain Lower Grade Glioma_LGG_TCGA-HW-7487-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K50976856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42341 lorglumide-5254 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null sensory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.442042 arecoline-2657 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TC-YIK COSMIC Cell Line Gene Mutation Profiles 1.0 null KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34635 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.958723 THP1 CCLE Cell Line Gene Expression Profiles -1.0 -2.16769 BRD-K01077691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74627 mouth TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null deptropine-5543 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.837782 BRD-K54931539 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15309 BRD-K02393180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11354 BRD-K56592061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.48955 KG1 CCLE Cell Line Gene CNV Profiles -1.0 -1.50267 PK45H CCLE Cell Line Gene Expression Profiles 1.0 1.45301 BRD-K50510710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06766 DDI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04298 BRD-K26852477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2834 ZFHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89328 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null CREB_DEPLETION_GDS3487_41_human_K562 myeloid leukemia cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22996 foliosidine-4295 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PPP2R5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06543 bephenium hydroxynaphthoate-5263 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833657 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.869749 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K09511124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.81996 BRD-K85851814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01431 meticrane-7282 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Chronic Myeloproliferative Disorder DisGeNET Gene-Disease Associations 1.0 null BRD-K27229533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21229 TIMM10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03412 ASMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44095 ABTB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98082 RALBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53416 PRSS50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89655 RIPOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11223 TBL1Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53468 T84 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pyrimethamine-4779 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SWSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87919 resveratrol-5509 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15767 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52691 SH3BGRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54596 H3K27me3_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65737790 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14412 BRD-K26051127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23288 USP31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33971 WDR37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96508 H3K9me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HCC1599 CCLE Cell Line Gene Expression Profiles -1.0 -2.0764 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059701 POMGNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21545 medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.858302 IRS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95357 CTSG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00502809 BRD-K28165728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27282 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.965372 spironolactone-6255 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null trichostatin A-364 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K32176914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33012 flucloxacillin-5527 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC12304111-41598_2025_13196_MOESM5_ESM.xlsx-Sheet_1-Table_S4_DEGs_Log2FC_1_and_p_adj_0_05_in_pancreatic_cancer_with_high_versus_low_OVOL1_expression_OVOL1 Rummagene Transcription Factor Associations 2026 1.0 null molindone-4784 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48277 proglumide-3780 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCC26 COSMIC Cell Line Gene Mutation Profiles 1.0 null reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39395 fluorometholone-6247 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K60834597 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45997 RUBCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17434 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3494 BRD-K47783463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94214 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07108 BRD-K28414977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09363 BRD-K10707948 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51474 BRD-K28299335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33986 NPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30704 butoconazole-3288 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COVID-19 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 BRD-K60701773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09278 ATG12 Hub Proteins Protein-Protein Interactions 1.0 null BRD-K66270896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1547 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_42_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05046 C14orf93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86564 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_7Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.01552 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATP1A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05511 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42031 Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 3.25179 PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null DBNDD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31585 canavanine-4197 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null alverine-6345 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lateral group of nuclei, right, dorsal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.874763 BRD-K83832060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12695 DNAJC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12683 valproic acid-5582 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39206 BRD-K21897482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17969 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.873027 Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31503053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50424 GRIN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18321 lateral dorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24919 heterotrimeric g-protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.556387 BRD-K02311826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1134 BRD-K91624805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57601 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7101-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cefotiam-5361 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NDUFB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97147 BRD-K04531886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11169 dropropizine-5531 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.536 tracazolate-2919 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K35035851 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16787 BRD-K20525312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19773 BRD-K03902845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08082 Kidney Chromophobe_KICH_TCGA-KN-8432-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null procainamide-4602 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K21009787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62003 not applicable_asthma_GSE43696_369_mouse_bronchial epithelial cell GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K79946769 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79979 phensuximide-3521 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K10325583 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20387 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGTPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69208 NCI-H2172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.898514 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CK-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU878 CCLE Cell Line Gene Expression Profiles 1.0 1.73013 N-acetyl-L-leucine-4622 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RIMS4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00492258 BRD-K77139764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.4765 ZNF429 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04931 BRD-K26196953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32848 PLPP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00642223 FAM171B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38803 ZNF100 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91008 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eye and adnexa disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040686 BRD-K33953218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14384 BRD-K53121826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02568 Brain Lower Grade Glioma_LGG_TCGA-DB-5270-01A-02R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lidocaine-1999 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AMO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NQO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87222 LAMA84 CCLE Cell Line Gene CNV Profiles -1.0 -1.99794 SHANK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40561 nomegestrol-5461 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null YH13 CCLE Cell Line Gene Expression Profiles -1.0 -3.28716 Lung squamous cell carcinoma_LUSC_TCGA-22-5491-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SDHAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76864 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043276 BRD-K08527280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40238 cell property TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.253248 AGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80399 EEF1AKMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30515 PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13 Rummagene Transcription Factor Associations 2026 1.0 null trifluoperazine-1224 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K78395012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0021 CDS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40205 CBFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01655 pregnenolone-2856 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null skimmianine-6066 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SLC12A9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00610855 TIE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26126 extrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.433012 PATU8902 CCLE Cell Line Gene CNV Profiles -1.0 -2.59454 PPIL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27579 PCDHB16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50949 FLYWCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67985 HSF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27201 USP17L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78783 BRD-K46308702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40185 BRD-K58985886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87295 tetraethylenepentamine-498 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF791 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77529 BRD-K56188606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35079 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85418917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23903 FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20174 T3M4 CCLE Cell Line Gene Expression Profiles 1.0 1.36882 CLUH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9172 SARC9371 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K23232542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82287 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null medial intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66492 ACYP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09156 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.43858 CRTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42581 vincamine-3784 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BSG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45139 MDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24321 gliclazide-2870 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ARTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01491 BRD-K78712486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03316 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.965372 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.72453 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.42789 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19384 vinpocetine-5859 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K32370845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78061 GPRC5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82693 RCOR1 ChEA Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5561-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07928699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21996 BRD-K03837143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53754 neomycin-7221 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null XIAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23656 H3K9me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PANC0327 CCLE Cell Line Gene CNV Profiles 1.0 1.84028 tanespimycin-6985 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.08258 ajmaline-1749 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23698 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.09276 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27498 COLO-741 COSMIC Cell Line Gene Mutation Profiles 1.0 null ARID4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75743 pregnenolone-2497 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848592 STOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64437 BRD-K78603273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70786 betahistine-4956 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K35943892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09158 gibberellic acid-4234 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TTNPB-223 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K70361311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13707 calmidazolium-486 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TGIF2LY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75684 BRD-K62256869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00062 BHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27678 RNF112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23301 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bezafibrate-4999 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K55393423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.58257 Brain Lower Grade Glioma_LGG_TCGA-CS-6667-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null diperodon-6836 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SO-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K41306114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.15371 UBE2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6906 CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02493 EZH2 ENCODE Transcription Factor Targets 1.0 null POU2F2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K23326916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38887 phenacetin-2471 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.45508 valproic acid-433 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K14251637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68621 cefadroxil-4161 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K67902591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0966 ATP11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41444 Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KCNC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00529391 Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K24864035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07434 CMK COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K38969544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10676 KRT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.319 chlortetracycline-2042 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K38434557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33262 TDRD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9205 SLC5A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38869 BRD-K43271856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60604 EPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96055 NEFM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11093 CERS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57571 podophyllotoxin-5841 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF513 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00566972 trifluoperazine-5442 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CDIPT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71672 methylprednisolone-3183 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K54079231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14452 Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80733946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64937 IGSF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9006 BRD-K81082554 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46833 lateral hemisphere of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986632 BRD-K47314501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00121 cefazolin-2564 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD34 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00549215 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 DST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42859 SAMD14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22437 agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09827 Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K54332480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08358 CAMTA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69885 Prestwick-972-6511 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K30379413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67477 BRD-K19752998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44759 Endometrial Carcinoma DisGeNET Gene-Disease Associations 1.0 null MRPS23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88304 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13614 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055576 BRD-K03361106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03147 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11228 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16587 RBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16171 RRP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58443 PA2G4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11414 estradiol-2701 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SLC11A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0069537 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08917 TP63 ChEA Transcription Factor Targets 1.0 null flucloxacillin-6507 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066295 proadifen-5807 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A-VN-1203-2004(H5N1)_Day7-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.2827 ART3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00596476 pyrantel-2260 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EFO21 CCLE Cell Line Gene CNV Profiles -1.0 -1.69194 BRD-K49051633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71291 BRD-K49005954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5811 BRD-K59670689 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42561 BRD-K04652643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14659 sulfapyridine-6799 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MRPL55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61702 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pridinol-7214 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K35617935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11816 AR ChEA Transcription Factor Targets 1.0 null BRD-K72452130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18012 picrotoxinin-4260 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KRTCAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36368 STOML1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92138 SPSB1 Hub Proteins Protein-Protein Interactions 1.0 null red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.66136 VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.913012 ZMIZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86025 Kidney BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.890167 BRD-K04087396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02143 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.068 remoxipride-6503 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36652 BRD-K30812092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.01385 0173570-0000-3690 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null chlorzoxazone-1416 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AGO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77238 extrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.456809 glibenclamide-1546 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FAHD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.029 MYB-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Hereditary Nonpolyposis Colorectal Cancer DisGeNET Gene-Disease Associations 1.0 null BRD-K98805845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92532 Premenstrual Syndrome DisGeNET Gene-Disease Associations 1.0 null BRD-K96547094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28375 STAMBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16019 LCLC103H CCLE Cell Line Gene Expression Profiles -1.0 -1.94018 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.9337 danazol-5315 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K41307047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15712 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.890342 BRD-K74916896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01686 TROVE2 Hub Proteins Protein-Protein Interactions 1.0 null BRD-K15775306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62385 Acute Megakaryocytic Leukemias DisGeNET Gene-Disease Associations 1.0 null CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null UBR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78125 CCNI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58838 Alexithymia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 PNU-0251126-3689 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K13792178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12913 DENND11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91305 (-)-MK-801-5003 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DMS-273 COSMIC Cell Line Gene Mutation Profiles 1.0 null LS1034 CCLE Cell Line Gene CNV Profiles 1.0 1.88215 MPZL3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00475093 HSC-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null GI-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K15343038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8391 NCIH2110 CCLE Cell Line Gene Expression Profiles 1.0 1.66812 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1308 inferior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.935763 Tendinitis DisGeNET Gene-Disease Associations 1.0 null LAMB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35801 chlorpropamide-141 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null levonorgestrel-3708 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K60353472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15519 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911956 BRD-K14255526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90297 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A8OC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3463457__F1 PFOCR Pathway Figure Associations 2023 1.0 null RGS13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00571158 MCF7 BioGPS Cell Line Gene Expression Profiles -1.0 -2.22683 V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.824905 BRD-K60662039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16959 KNS-81-FD COSMIC Cell Line Gene Mutation Profiles 1.0 null bufexamac-5515 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K21544408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03228 HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.65521 Anemia DisGeNET Gene-Disease Associations 1.0 null BRD-K33597325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43006 SDHD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00557302 BRD-K31602570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34876 body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.49518 plantlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.30253 BRD-K01022714 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52141 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.848489 valproic acid-5569 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K95323025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71597 FAAP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4165 HCC1195 CCLE Cell Line Gene CNV Profiles -1.0 -1.8116 CEP170 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99639 G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.873027 BRD-K21996189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18336 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 BRD-K71982936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18295 BRD-K09975370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29073 bromopride-4278 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null alpha-estradiol-122 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null isocarboxazid-2562 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.873027 ARSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4173 ZNF606 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19304 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3747 PTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87933 BRD-K02190643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52783 AURKA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28113 suxibuzone-5806 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GMPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85234 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPS6KA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02518 NCI-H2461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03888 NATD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78399 mepyramine-3184 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K63803358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07328 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.922367 BRD-K52932858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70646 GPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45851 betamethasone-6728 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hexylcaine-2708 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.08391 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.856277 RPS6KA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96038 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-4670-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 quinidine-6267 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null dihydrostreptomycin-5751 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LY-294002-5942 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null bumetanide-5117 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18371 FOXQ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87314 pargyline-2265 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.945435 endopiriform nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.21281 HMGCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90213 zona incerta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07329 plumule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.377996 ZFTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7907 BET1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68098 MK-886-264 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.240497 HOS CCLE Cell Line Gene Expression Profiles -1.0 -1.52305 BRD-K00086692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47599 nizatidine-5406 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K44224150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9826 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UR-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40474424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38022 probenecid-4771 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KCNA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93312 medial parabrachial nucleus,right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.91306 STX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58748 BRD-K07988588 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45803 doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63462 Pancreatic Carcinoma DisGeNET Gene-Disease Associations 1.0 null outer CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03096 GRSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6702 nimesulide-7024 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K30632097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0575 selegiline-2826 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null U266B1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44188 proxyphylline-6494 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF785 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27319 ALEXANDERCELLS CCLE Cell Line Gene Expression Profiles 1.0 1.51029 Gingivitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.085 MMP24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18616 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 NUDT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92203 BECKER CCLE Cell Line Gene Expression Profiles -1.0 -1.64363 Acute Myeloid Leukemia_LAML_TCGA-AB-2817-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K24978625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12863 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042803 ifosfamide-5805 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.86845 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26029 3-aminobenzamide-590 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null exocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HDAC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74847 LMSU CCLE Cell Line Gene CNV Profiles -1.0 -1.92937 SARNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59848 BRD-K23064726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19518 KATNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04548 BRD-K42987166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31882 RNASET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35287 BRD-K90649428 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54687 TNFSF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19886 BRD-K51791049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23967 ATF7IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03589 PRDM12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11937 BRD-K02024244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.4028 tiratricol-7011 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ELOVL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54013 HOXC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03952 iloprost-427 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C15orf40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13896 N6-methyladenosine-6732 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K95577144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09023 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96391 phosphoserine Phosphosite Textmining Biological Term Annotations 1.0 null CAPZA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.75392 Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49473928 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02609 BRD-K95033255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20133 etodolac-2254 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RCHACV CCLE Cell Line Gene Expression Profiles -1.0 -2.12027 RETREG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75341 BRD-K53931904 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02375 isoetarine-5812 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K20028734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0672 BRD-K48052543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64223 PMC6802116-41467_2019_12517_MOESM5_ESM.xlsx-Sheet1-D9_8_GNF2-SERPINB5_CENPX Rummagene Transcription Factor Associations 2026 1.0 null liothyronine-2984 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null retinal cell cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.446935 Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16884266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02132 BRD-K18768055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29025 FAM162A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3132 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10193 LUZP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61949 BRD-K35863275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08697 5707885-6390 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZBTB40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42044 BRD-K75845970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50835 BRD-K35383890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51319 BRD-K62324460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0829 inferior occipital gyrus, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06402 guaifenesin-4549 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K98704738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82505 BRD-K87053028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34426 dizocilpine-1386 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K88977610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08058 benzathine benzylpenicillin-2939 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COLO680N CCLE Cell Line Gene Expression Profiles -1.0 -1.68886 EKVX BioGPS Cell Line Gene Expression Profiles -1.0 -1.16885 TOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00749 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K29684372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80799 kaempferol-7196 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hydrocortisone_homo sapiens_gpl201_gse21909 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PFKP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91596 flurbiprofen-6472 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K75703503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08184 cinchocaine-4149 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CDX2-19796622-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MTHFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89327 TRPM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606544 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59966 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16648 RAB11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40808 LRRC47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48791 BRD-K98271666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5658 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 4.464 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00492 BRD-K56309946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50722 KCNK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87224 BRD-K97086564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21009 BRD-K81293413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35016 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.341 KYM1 CCLE Cell Line Gene Expression Profiles 1.0 1.68106 BRD-K90863245 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49407 Multiple Chronic Conditions DisGeNET Gene-Disease Associations 1.0 null cloperastine-2549 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885585 BRD-K32472782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13782 BRD-K35171408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36033 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 PLEKHA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89513 BRD-K47092271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34955 paromomycin-3356 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.62756 MIER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35569 ZSWIM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32433 BRD-K24109044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26811 UBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96804 BRD-K07278815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91878 Bone inflammation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.196 hsa-miR-616 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.32683 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPO11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12058 ATP6AP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9347 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A913-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.45508 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06626 E2F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55058 DBN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34007 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00705 AMMECR1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8697 POLR2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27915 wortmannin-5603 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00705 CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.23006 TCTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85352 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.943823 RL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.912937 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 BRD-K70949282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8708 Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.02548 BRD-A68123879 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15744 trichostatin A-6222 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.833085 BRD-K02675272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15984 BRD-K45677596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10317 HS737T CCLE Cell Line Gene Expression Profiles -1.0 -1.62773 iohexol-3322 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K26472648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21791 seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.566828 PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S6-Table_S6_MR_results_of_the_significant_genes_from_human_brain_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null IA-LM COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 monorden-493 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nalidixic acid-2336 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.295 T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.01478 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67346 BRD-K62236460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19981 MORCPR CCLE Cell Line Gene CNV Profiles -1.0 -1.5293 stratum pyramidale of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03454 prochlorperazine-2641 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Post Essential Thrombocythaemia Myelofibrosis DisGeNET Gene-Disease Associations 1.0 null CASKIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69487 BRD-K42757676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08724 OPM-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K28559679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17987 JADE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.95961 ZFP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7474 WSU-DLCL2 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A20463452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94473 BRD-K38417094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20437 Burning Sensation DisGeNET Gene-Phenotype Associations 1.0 null MACF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53115 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.49 Spinal Cord Injury(Homo sapiens) WikiPathways Pathways 2014 1.0 null BRD-K34028745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01976 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.926746 Multiple Myeloma DisGeNET Gene-Disease Associations 1.0 null chlorhexidine-1942 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.052945 BRD-K05335635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64591 pregnenolone-4802 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K74834319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4681 metformin-1 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K53489056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23881 Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null microbody LOCATE Predicted Protein Localization Annotations 1.0 null Onchocerciasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.019 trimethobenzamide-4180 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.415 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925196 LBR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56337 Sleep Apnea DisGeNET Gene-Disease Associations 1.0 null SLC25A36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25371 BRD-K41311678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17282 cell part LOCATE Predicted Protein Localization Annotations 1.0 null HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59699 CDK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79561 fludrocortisone-3977 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null plant form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.242983 SLC5A3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00417182 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041197 hsa-miR-1272 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 HEC6 CCLE Cell Line Gene Expression Profiles -1.0 -1.78962 BRD-K49039223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1011 NR2E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13236 HPS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7006 BRD-K08489825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53151 betaxolol-3208 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null enilconazole-6518 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K35727000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75492 SC-58125-507 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC4823830-ncomms11171-s3.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null pirinixic acid-495 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null acepromazine-6832 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-3920 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 BRD-K23024526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94624 BRD-K07557785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89269 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 STARD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59099 NCI-H1568 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCRTR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00577043 NU-1025-608 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K57365604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.499 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prestwick-981-7464 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF446 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6404 LAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77164 sirolimus-5602 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nerve GTEx Tissue Gene Expression Profiles 1.0 0.962331 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30799 iopanoic acid-2965 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08995282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87726 seed TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.359664 MRPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4796 SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K36289678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63795 BRD-K69443135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12249 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52691 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.54946 16-phenyltetranorprostaglandin E2-7546 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null anteroventral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.892105 caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12643 BRD-K17405621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63192 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.091473 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.848489 ampicillin-5408 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pivmecillinam-2973 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null salsolinol-4816 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null netilmicin-7302 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65476 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05537 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41322 THYN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87374 HEC265 CCLE Cell Line Gene Expression Profiles -1.0 -2.65399 meclocycline-6637 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K77074748 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37271 tiratricol-2259 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null bucladesine-591 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null adenosine phosphate-5359 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null extracellular region GO Cellular Component Annotations 2015 1.0 null IGFBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60842 side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.165932 BRD-K12866026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43728 TRMT9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78002 KYSE-70 COSMIC Cell Line Gene Mutation Profiles 1.0 null Sialolithiasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.358 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null clidinium bromide-2734 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60760423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06433 BRD-K80715600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86566 LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053113 BRD-K75041866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64403 Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 CDX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29339 BRD-K32511780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23365 BRD-K88941096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12584 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67346 DCUN1D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76639 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BPTF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14764 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.01208 SNU869 CCLE Cell Line Gene Expression Profiles 1.0 1.41684 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.883303 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.893402 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20919 catalytic complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044216 BRD-K78344913 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09564 danazol-2038 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Arthritis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.192 BRD-K07602825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20575 BRD-K42032479 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01718 BRD-K42671261 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32931 BRD-K34405227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13086 DAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57298 UMC-11 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 testosterone-5271 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21151 Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null coralyne-2652 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cefalotin-6079 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TIRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6991 BRD-K07697589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.46469 BRD-K15128331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1692 pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.928654 outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09864 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36786 mexiletine-2324 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06834318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20582 BRD-K23533429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00552 Pelizaeus-Merzbacher disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.292 BRD-K37558338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09294 cefaclor-2483 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K83562499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09615 BRD-K38669793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04729 BRD-A48913311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04396 M14 BioGPS Cell Line Gene Expression Profiles -1.0 -0.909898 Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A6GD-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.385 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.910062 MZ7-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null DAOY CCLE Cell Line Gene CNV Profiles -1.0 -1.46335 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06589 SAAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29836 BRD-K84077642 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19339 AKR1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28876 BRD-K30973947 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03643 HEC59 CCLE Cell Line Gene Expression Profiles 1.0 2.65491 BRD-K96057608 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.44731 salbutamol-2306 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K90155857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2052 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041846 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S3-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NP-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.910062 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null BRD-K70042405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58342 nabumetone-6487 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.55391 brain GTEx Tissue Gene Expression Profiles 1.0 1.19374 HUT102 CCLE Cell Line Gene CNV Profiles -1.0 -3.20931 epitiostanol-2922 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TSKU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03604 CHGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1894 BRD-K49570068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16107 BRD-K32943037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3006 alimemazine-7235 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K88150784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57729 Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30338 disopyramide-7276 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54334 KDM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82467 leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.380251 NH-12 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K75243062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32675 MOV10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80999 ASNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11926 NUP214 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38092 KLF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27464 BRD-K19672435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13863 BRD-K86630280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03204 BRD-K87602457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74098 SNX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0911 extracellular region LOCATE Predicted Protein Localization Annotations 1.0 null delsoline-7212 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K79709959 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09622 NYNRIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31919 methoxamine-2488 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K07020302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33401 SNU-449 COSMIC Cell Line Gene Mutation Profiles 1.0 null MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.33706 Hypertrophic Cardiomyopathy DisGeNET Gene-Disease Associations 1.0 null NCI-H835 COSMIC Cell Line Gene Mutation Profiles 1.0 null RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K33438042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77045 CDK11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72158 BRD-K84178323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40332 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.78808 BRD-K65529782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49737 Spinal cord injury WikiPathways Pathways 2024 1.0 null A-CA-04-2009(H1N1)_0Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.24403 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.988233 PPP1R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96708 0173570-0000-4715 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.494 BRD-K06873288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55587 BRD-K60337438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07828 BRD-K09258973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10487 meclofenamic acid-2128 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K01774461 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10631 rimexolone-5517 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.991361 PL4 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 BRD-K73669270 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1095 isradipine-6347 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K11631946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60034 Ectopic Cushing syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.028 BRD-K47988839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01156 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00401 BRD-K37253987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19403 CD93 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00532581 BRD-K30581008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52144 JHH-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K16502264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13696 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null novobiocin-499 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null sulfametoxydiazine-5732 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.164 probenecid-2464 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P3H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45626 niridazole-4621 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.34645 BRD-K19168437 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10637 NCI-H650 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 sulfadiazine-5523 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.882241 Malignant tumor of pancreas_saliva_GSE14245 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.2385 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K92433833 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13542 CL-40 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.975192 BRD-K92655427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09259 BRD-K17339982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24436 BRD-K11846531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36156 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911078 ASPHD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00529114 Lung squamous cell carcinoma_LUSC_TCGA-77-7141-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-SNU-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.88912 PPDPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03801 telenzepine-5096 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null omeprazole-4951 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ERCC6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24832 IRAK1_knockdown_115_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.80429 MBD3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80658 Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MISP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91172 BRD-K19418944 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14755 SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911956 doxorubicin-4610 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20856 eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040927 SDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2366 SKP1 Hub Proteins Protein-Protein Interactions 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.005 ARL6IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13377 eldeline-3925 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K66187822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13082 CD83 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7158 A375 COSMIC Cell Line Gene Mutation Profiles 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43534 cyclizine-5525 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SKMEL31 CCLE Cell Line Gene CNV Profiles 1.0 1.42283 BRD-K84233365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83141 BRD-K49159670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85606 USP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09168 conessine-2135 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K78837609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07468 BRD-K98891210 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41196 SLC2A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47509 Ebolavirus(ZEBOV)_6day_PBMCs_rhAPCtreated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.037074 FUOV1 CCLE Cell Line Gene CNV Profiles 1.0 2.30891 PCBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01867 CDX2 ChEA Transcription Factor Targets 1.0 null dirithromycin-1712 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K30589514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6526 SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -1.56445 copper sulfate-500 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null monorden-6979 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COLO-678 COSMIC Cell Line Gene Mutation Profiles 1.0 null natamycin-3548 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ARPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08953 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32056 T47D CCLE Cell Line Gene CNV Profiles -1.0 -2.30754 procainamide-5663 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20174 BRD-K87821938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29859 orciprenaline-2485 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KAT2A Hub Proteins Protein-Protein Interactions 1.0 null SNU738 CCLE Cell Line Gene Expression Profiles 1.0 1.64107 estradiol-1208 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TBC1D10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92403 CLDND1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00531145 BRD-K07740919 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10694 sulfamethoxypyridazine-3711 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K80296876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19412 KDM2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67365 PRICKLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31379 WDR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22282 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.1613 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04367 APRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59319 KYSE-220 COSMIC Cell Line Gene Mutation Profiles 1.0 null azacyclonol-2020 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EML4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3767 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.955034 UBE2E2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00533788 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 W-13-440 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KASUMI1 CCLE Cell Line Gene Expression Profiles 1.0 1.47638 flupentixol-2643 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PUSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40921 AKR7A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90455 EXOC3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49826 saliva TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LOU-NH91 COSMIC Cell Line Gene Mutation Profiles 1.0 null dyclonine-7261 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null fallopian tube GTEx Tissue Gene Expression Profiles -1.0 -1.38022 pineal_day BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.23168 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K19381111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47423 Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 BRD-K16802067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78886 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null AMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85796 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Deficiency Of Glucose-6-Phosphate Dehydrogenase DisGeNET Gene-Disease Associations 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_33_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null nitrendipine-336 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null spiradoline-4553 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04067 BRD-K19175647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01233 guaifenesin-2569 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pseudopelletierine-1774 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null idoxuridine-1980 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K74211805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04258 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.634 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52691 Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ceftazidime-5473 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K85525164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24319 LS513 CCLE Cell Line Gene Expression Profiles 1.0 1.85028 AR-19668381-PC3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null plant embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.372369 BRD-K56437119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7029 PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null KMH-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Salivarygland BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.72748 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.872406 sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040423 AFAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80874 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC52A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49491 BRD-K32960568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25642 BRD-K09863466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37217 Eye accommodation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.474 miconazole-4960 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.287092 ADRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63127 BRD-K30220159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07598 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.894 torasemide-3517 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null rent1_15448691_hela_lof_human_gpl8300_gds705 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.494737 EPHB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40773 SPINK4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00622297 GIGYF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09578 buflomedil-4840 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null timolol-5280 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.72566 BRD-K47584662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79798 kanamycin-3224 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null celecoxib-206 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1155 CCLE Cell Line Gene CNV Profiles 1.0 2.11202 CBC601 (RAD18) NURSA Protein Complexes 1.0 null flunixin-2552 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.556387 Retinitis pigmentosa 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 BRD-K78668110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66119 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lingual gyrus, left, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16185 NCIH28 CCLE Cell Line Gene CNV Profiles -1.0 -1.57852 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.873027 dizocilpine-5746 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null enilconazole-5113 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null WDR87 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00475234 U20S BioGPS Cell Line Gene Expression Profiles 1.0 1.20792 BRD-K80424876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43797 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.37105 CDX2-19796622-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NEC8 COSMIC Cell Line Gene Mutation Profiles 1.0 null extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H4C8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99858 BRD-K21119095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39775 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.03913 POGLUT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26761 CTBP2-25329375-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RCOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73592 NASP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28812 putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.61094 BRD-K54456668 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.6589 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.973 FTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53822 BRD-K03331449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2984 tanespimycin-5566 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A618-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Diabetic Nephropathy_Renal Tissue_GSE1009 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 0.435199 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.384 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49046 probucol-592 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LRRC58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94224 BRD-K84988480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06698 BRD-K18856772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06911 EGFL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09144 sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.633549 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.849165 TEAD1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K47574423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13825 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.403 OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40915 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50113 Lung squamous cell carcinoma_LUSC_TCGA-85-8049-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF518A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01442 B4GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1503 Pasteurellosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.541 interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.550503 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13959 BRD-K63401195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24299 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.0408 XPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30082 foliosidine-6057 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K35964249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04172 TOP1 Pathway Commons Protein-Protein Interactions 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050893 Polycythemia Vera DisGeNET Gene-Disease Associations 1.0 null BRD-K10748141 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41287 BRD-K67586245 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0604 oxybuprocaine-3996 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FAM20B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84517 Kidney Chromophobe_KICH_TCGA-KL-8323-01A-21R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83135 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.35903 BRD-K54837058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61641 aminophylline-5395 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tretinoin-224 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.079231 BRD-K91980109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01112 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -0.963751 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K83028309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05746 alpha-ergocryptine-2572 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CD101 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00579752 STARD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63437 pirenzepine-5872 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null OVCAR-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null dipyridamole-1517 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K66963616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12634