association	dataset	threshold value	standardized value
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	1.0	1.86861
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85989
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2501
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.97336
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22631
CYB561	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73899
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LRP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2312
SMARCC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03243
Lung adenocarcinoma_LUAD_TCGA-55-7570-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PCBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22196
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14298
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977359
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45657
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4228-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855901
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HIF1A_01_224	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63031
PLEKHG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11155
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36994
NCIH2347	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71165
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE76425_1_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6465-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IP6K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36973
GABRA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5047
dorsal part of alar p2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60705
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.38495
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.921546
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859878
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44779
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24262
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.888
LN443	CCLE Cell Line Gene Expression Profiles	1.0	1.41234
SCAI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84631
SNU245	CCLE Cell Line Gene CNV Profiles	1.0	1.77571
GTEX-PX3G-0226-SM-3NB2C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6704
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05893
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43041
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980026
LMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37122
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10375
MRPS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73279
LRRC45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64237
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.991928
496100623_PCx_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.99309
SP100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36529
PGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43654
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2685
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928159
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31078
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.929654
metabolic process	GO Biological Process Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03921
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98728
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58416
intermediate stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0565
GTEX-O5YW-3026-SM-3MJHI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843763
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12441
OB granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.08821
PPIL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63774
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BAG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81439
NCI-H64	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988652
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3323
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889968
GSTCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95358
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endometrium_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.46337
Utricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
cuneiform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.995314
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948129
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06389
CMK86	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70956
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25318
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25347
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220831
ETF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68219
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, unassigned, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24357
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67073
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09722
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87084
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ5-1826-SM-3NB22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72453
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33737
IPO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22091
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2845
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF503	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98105
TRIM16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01786
HUS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46718
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48652
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869738
MCRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31524
Interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43315
mantle zone of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06721
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832703
RC-K8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ANKRD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52542
OB outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02128
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.972281
GTEX-QDT8-0008-SM-48U2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92215
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27331
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4444
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970763
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831177
GER cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
Platelet dense granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.596
PPME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61229
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2779
EED	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83547
RND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41517
SF767	CCLE Cell Line Gene CNV Profiles	-1.0	-2.79895
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EIF2AK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80297
Main olfactory bulb, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20562
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835252
SUZ12	ENCODE Transcription Factor Targets	1.0	null
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
endopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
U87MG	DepMap CRISPR Gene Dependency	1.0	2.18118
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC202	CCLE Cell Line Gene CNV Profiles	1.0	1.46373
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973708
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.56026
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80532
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3624
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOC4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23057
superficial stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03722
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.829922
RPS6KA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02518
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89664
EOLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09615
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07385
intermediate stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16085
ZNF516	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27076
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98237
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839129
Kidney Chromophobe_KICH_TCGA-KO-8415-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880028
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39186
Lung adenocarcinoma_LUAD_TCGA-95-7947-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06516
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.965228
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69829
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL120	DepMap CRISPR Gene Dependency	1.0	2.9552
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF354C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33716
GTEX-P4QT-1326-SM-3NMD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930284
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21675
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52272
TRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49529
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02158
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03243
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40057
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.952435
EEIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34861
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.966082
GTEX-R55D-0326-SM-48FES	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877632
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tendon sheath	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90969
SNU410	CCLE Cell Line Gene Expression Profiles	1.0	1.55301
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25986
FEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47126
HDAC2	ENCODE Transcription Factor Targets	1.0	null
caudal interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15322
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896468
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32292
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q734-1926-SM-2I5EV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99842
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69962
DDX3X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86359
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.94407
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FBXL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55737
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
NSMCE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27862
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29321
NCIH1793	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76057
PMC12659123-12864_2025_12285_MOESM12_ESM.xlsx-Table_S12-Table_S12_Differentially_expressed_genes_after_SPI1_knockdown_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59658
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1434
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09105
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.964815
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.3249
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09408
Cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.217
CSNK2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12549
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37045
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34099
C5orf22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88778
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857243
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KCNK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58897
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18359
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051237
Pancreatic adenocarcinoma_PAAD_TCGA-PZ-A5RE-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KYSE520	CCLE Cell Line Gene CNV Profiles	1.0	2.04495
ZCCHC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69985
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60725
Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24357
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EEF1AKMT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73797
Methionine	CTD Gene-Chemical Interactions	1.0	null
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947351
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055768
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.940136
RT112	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.03148
serine hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.19292
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.74745
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08949
Taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09291
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900184
IGFBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01027
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955518
CEBPZ_02_118	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61203
COLO741	Achilles Cell Line Gene Essentiality Profiles	1.0	1.28782
lateral septal nucleus, intermedio-ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08208
Adrenomedullin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.588
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98353
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13352
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.79559
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EMC-BAC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.16028
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ampulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
Prostate adenocarcinoma_PRAD_TCGA-G9-6333-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11041
GDM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01549
p3 portion of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03797
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79712
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CLDN19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29956
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A4ZW-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18953
CLDND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27787
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.241
Central lateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01111
VAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70696
GORASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91938
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.1474
TNNC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52374
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GLCCI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58724
ANKRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39644
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lewy body dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
LN443	Achilles Cell Line Gene Essentiality Profiles	1.0	2.48198
anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.845541
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XK95-0426-SM-4AT4R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855072
RPAIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53795
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3734
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11077
GTEX-QV44-1825-SM-447CF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832807
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C2orf69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99774
hsa-miR-1293	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.2083
ADAMTS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93071
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982193
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.959641
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basointermediate isthmic reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30013
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86186
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13I-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07139
pyramidal layer of taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81863
BACH1	ENCODE Transcription Factor Targets	1.0	null
peptidase activity, acting on l-amino acid peptides	GO Molecular Function Annotations 2015	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.80905
Main olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14505
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.916332
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944877
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A2QR-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.17568
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SH2B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82362
CIPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05607
Tongue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.86437
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.898397
extracellular matrix	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PDE10A_KO_GDS4542_292_mouse_hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BECN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10751
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4810-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59694
CABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93637
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41136
Usher syndrome type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
PGM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84771
RMDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80291
IGDCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41634
SNU620	DepMap CRISPR Gene Dependency	1.0	2.44185
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Taenia tecta, dorsal part, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71747
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eGFP-FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834192
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01677
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49946
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28646
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94646
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878866
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.7541
IRF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1051
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAV3_Deficiency_GDS3552_558_mouse_Hearts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
LUDLU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60975
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9052
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.360409
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7193
ES5	DepMap CRISPR Gene Dependency	1.0	3.17249
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.830068
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10534007-Table_2.xlsx-S3_unique_up_MSC_V-817_elements_included_exclusively_in_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14695
superficial stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0167
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16463
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81326
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KRTCAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3673
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10597
BICR31	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8563805-41598_2021_858_MOESM2_ESM.xlsx-Supplementary_Info_8-Gene_List_8_The_list_of_human_orthologs_of_the_downregulated_fly_DEGs_identified_from_PARIS_C571A_mutant_vs_PARIS_wild_type_comparison_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
single	GeneRIF Biological Term Annotations	1.0	null
NDUFA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91832
CAMKK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58892
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31584
ZNF671	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42833
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19N-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KML1	DepMap CRISPR Gene Dependency	1.0	2.96308
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.875781
OVOL2_01_313	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.29062
COMMD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15643
RPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11552
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03175
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847764
CYREN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89022
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0852
VPS33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03458
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25961
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.995936
SNU182	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
TTLL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66168
reuniens nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16943
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16557
TYMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68373
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
placenta_3a	HPA Tissue Sample Gene Expression Profiles	1.0	0.887496
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157050,GSE157051_2_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PIGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78843
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36572
GTEX-PW2O-0526-SM-2I3DX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08465
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6147
GTEX-VJYA-1326-SM-3GIJC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11669
HUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28316
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14769
remain	GeneRIF Biological Term Annotations	1.0	null
SNU449	CCLE Cell Line Gene Expression Profiles	1.0	1.40035
TMEM263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88813
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Neurological pain disorder_Dorsal Root Ganglia_GSE15041	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.27152
MTHFS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14925
THBS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76971
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03709
GTEX-Q734-0626-SM-2I3EF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947896
SEC24A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87207
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.21791
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5585
hela	HPA Cell Line Gene Expression Profiles	1.0	2.14514
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02068
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06257
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79148
KLF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10532
GTEX-XQ8I-0526-SM-4BOPS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12109
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18805
IKBKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24152
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71355
Orbital area, ventrolateral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1225
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INO80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02775
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PRKCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5802
intermediate stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08382
SNAPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38096
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81943
Liver hepatocellular carcinoma_LIHC_TCGA-HP-A5N0-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17983
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLR20	CCLE Cell Line Gene CNV Profiles	1.0	1.88162
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01716
TBX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29233
GTEX-V1D1-0226-SM-4JBHG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00928
Retrocerebral complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10727
PCDHB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92823
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.940272
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.17866
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32986
UNC13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23932
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02451
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10888
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07076
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITPRIPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07869
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40271
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	1.40312
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851907
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ABCB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60441
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.942059
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01628
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48483
NP5	DepMap CRISPR Gene Dependency	1.0	5.93106
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878866
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.74253
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926076
BCL11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15988
TTLL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29385
embryoday7.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.893623
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8307-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22608
SULT2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65923
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.959147
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYNJ2BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35357
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29738
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19859
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CUX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68696
Lung squamous cell carcinoma_LUSC_TCGA-22-5483-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	1.0	2.10691
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.067
RAD21	ENCODE Transcription Factor Targets	1.0	null
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11495
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.33859
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Appendix cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3462
NKRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93395
SLC7A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03833
KP-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
central lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20411
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52788
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22642
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5653
ZNF256	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60856
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02093
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79062
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.72436
Thyroid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.19755
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G-292_CLONE_A141B1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6715
H3K27me3_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.67992
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21432
EBF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71149
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Rabies CVS-11_7day-Brain_22116324_GSE30577	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89358
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15861
TE9	Achilles Cell Line Gene Essentiality Profiles	1.0	1.00498
RND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02787
PRKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28303
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ES5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NAA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14553
Mpf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.813
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.848178
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51632
ELAVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97737
Taenia tecta, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59455
SLC2A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45229
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-1026-SM-46MVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15053
Taenia tecta, dorsal part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29936
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36044
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.894
KIF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45203
Midline group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07888
prostate	HPA Tissue Gene Expression Profiles	-1.0	-1.28438
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.842448
ZNF837	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56669
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.98096
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.909671
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20346
AMZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34601
Fat-macrophage	Tabula Sapiens Gene-Cell Associations	1.0	8.23114
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.948906
polypeptide	GeneRIF Biological Term Annotations	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-geneid_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CNBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10236
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948415
DIMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88683
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.86776
Adrenocortical carcinoma_ACC_TCGA-OR-A5LA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GNPNAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14977
Superior olivary complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36455
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828535
Rectum adenocarcinoma_READ_TCGA-DC-4749-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03016
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2845
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46353
Median preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02921
MED20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99742
IVNS1ABP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80791
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40744
central part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23116
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.903835
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5487
LMO2-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50465
m2 part of pararubral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57562
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.19737
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYJK-1426-SM-3NM8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14922
rectum_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.05232
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14172
SLC29A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49876
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28458
tendon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
LHX8_Deficiency_GDS3254_600_mouse_Newborn ovaries	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KYAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30474
SIDT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25938
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NCIH1915	DepMap CRISPR Gene Dependency	1.0	11.1936
CRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12108
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60389
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.872227
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AEN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49807
HJURP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30918
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.869
AAAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04975
PSMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29567
MVB12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38688
MRRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36421
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13146
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.912343
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996413
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33857
GTEX-U3ZN-1926-SM-4DXSG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17671
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.013
SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.6173
HT1376	CCLE Cell Line Gene CNV Profiles	1.0	2.27624
TOV21G	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.2152
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUTM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9786
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0871
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825057
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09484
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.866175
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4062
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.8113
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987567
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20615
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.218715
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84129
Cingulate gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.181
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33005
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64484
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49335
Perturb_12858_KO_Ift88_SRP125630	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.63203
ovary_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.46283
SLR23	DepMap CRISPR Gene Dependency	1.0	4.75416
preopto-hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3557
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842178
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75071
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
NFATC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42083
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5403
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52499
H6PD_KO_GDS3195_603_mouse_Skeletal muscle - Tibialis anterior	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
EFEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50445
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7574
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2860-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.69512
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43848
BANF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77534
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50924
TFEB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49438
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38827
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LRRC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09783
GSE169571_3_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18772
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.05274
Autoimmune thyroiditis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.925
LMAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57896
SNU1077	CCLE Cell Line Gene CNV Profiles	1.0	1.45021
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56539
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.965765
GTEX-S7SF-0426-SM-3K2B7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07108
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.86113
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.2611
plexiform layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48141
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.925492
MMP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76019
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5282
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72216
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832508
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.2059
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18081
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48062
outer CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.938633
HNF4A	ENCODE Transcription Factor Targets	1.0	null
CHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06491
EJM	CCLE Cell Line Gene CNV Profiles	1.0	1.54929
GTEX-XUZC-1126-SM-4BOPZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63034
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
T-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.3744
GTEX-RVPU-0008-SM-3NM8B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28567
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68333
Perturb_6702_KD_PLAGL2_SRP164912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.05274
H3K9ac_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44178
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area, ventrolateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01013
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65613
MRPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32265
PPARD	ChEA Transcription Factor Targets	1.0	null
EHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87654
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13226
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
ZNF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6695
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23116
HS746T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11649
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.43307
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50694
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980567
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984379
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.485693
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFON-2226-SM-3TW8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40573
Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4649
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.6821
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.94683
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.120477
RABL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25272
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20735
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.934357
SETDB1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
INPP5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03484
EWS502	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.78444
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05998
cellular_component	GO Cellular Component Annotations 2015	1.0	null
FHOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43509
SNTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99942
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBC1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26818
nucleus of the diagonal band, left, vertical division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38325
Perturb_15983_KO_Larp7_SRP189392	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.55779
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48746
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09262
SLR20	DepMap CRISPR Gene Dependency	1.0	2.07821
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.59939
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36822
GTEX-XLM4-1026-SM-4AT51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47071
GTEX-PLZ4-0226-SM-2S1NW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6915
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81K-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79612
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74972
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40252
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20969
Lung squamous cell carcinoma_LUSC_TCGA-34-5239-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH810	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07236
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2111
MEF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21937
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.8721
H3K27me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14217
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.923148
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.248
PMC10322668-Table_7.xlsx-DE_genes_at_early_infection-List_of_de-regulated_genes_at_early_interaction_time_point_of_Dm28c_T_cruzi_THP1_infected_cells_From_Libisch_2020_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
TRRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24293
Endocrine system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36572
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.888974
layer 4 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33466
GB1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.751
PALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15885
GTEX-UJMC-0426-SM-4IHJF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3584
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02826
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NIPSNAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3155
IDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88101
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3999
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75713
S117	CCLE Cell Line Gene Expression Profiles	1.0	1.50617
GTEX-XAJ8-0526-SM-47JYK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866964
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.38
Corpus cardiacum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.657
serine-type endopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QLQW-0426-SM-447A7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931061
Tendon sheath	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23991
TSTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59125
CRABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06047
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.897173
GTEX-QV44-0926-SM-2S1RH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42417
C14orf28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37053
AURKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49954
C1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4462
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27267
Perturb_690_KO_RORA_ERP111466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6325-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EPB41L4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97741
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.0584
TMEM106A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18725
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
enzyme	GeneRIF Biological Term Annotations	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.91095
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glaucoma_Retina_GSE3554	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.04535
C6orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61602
KLHL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16534
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35461
whose	GeneRIF Biological Term Annotations	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.901053
OGFRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61361
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100630_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60243
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09271
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13229
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.31664
Lung squamous cell carcinoma_LUSC_TCGA-68-7757-01B-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC30A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94244
ZNF624	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76894
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEIOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52313
ZNF322	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42377
THP1	CCLE Cell Line Gene Expression Profiles	1.0	2.21873
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
septostriatal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03722
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20941
hsa-miR-3940-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5213
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02587
BABAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78009
SDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42023
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1029
VPS37C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33419
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3353
mouth	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27me3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73977
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994451
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.370121
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85339
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5771
RWDD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49653
EEF1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2911
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.07432
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4TI-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38301
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_SOX2_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5754
HMGN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08615
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853181
OB inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30813
Lung adenocarcinoma_LUAD_TCGA-75-5122-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20331
Pancreatic adenocarcinoma_PAAD_TCGA-YB-A89D-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYP26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09472
SKP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43184
TRIM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18328
NCI-H2087	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01744
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.943275
PPARGC1A_NULL MUTATION_GDS2149_721_mouse_Brown adipocyte	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hel	HPA Cell Line Gene Expression Profiles	1.0	1.07804
HT144	DepMap CRISPR Gene Dependency	1.0	3.93454
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
WDR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84958
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38019
SP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07916
intermediate stratum of r5Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13921
P63-20808887-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
STON1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02822
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07768
Heschl's gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60296
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	2.72015
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8877
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0945
thp1	HPA Cell Line Gene Expression Profiles	1.0	1.12691
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
prostate	HPA Tissue Protein Expression Profiles	-1.0	-1.05274
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44911
SPECC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73963
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848167
L-1236	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OXRK-0926-SM-2HMKP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960307
inferior temporal gyrus, right, bank of the its	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.963111
496100585_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.09564
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.19509
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12909
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43223
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45599
BOLA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72076
GTEX-UJMC-2026-SM-3GADR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11833
COLO668	CCLE Cell Line Gene Expression Profiles	1.0	1.68805
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFKB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03179
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040339
ENDOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.33253
EWSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77336
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76786
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.05186
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPIC-1726-SM-4IHKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04417
MRPL52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06382
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27426
adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.437154
TCF12	ENCODE Transcription Factor Targets	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS26	CCLE Cell Line Gene CNV Profiles	1.0	1.68908
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40285
NCIH854	CCLE Cell Line Gene Expression Profiles	1.0	1.76662
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54759
OCI-AML3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6941-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM87B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38881
LC1SQSF	CCLE Cell Line Gene CNV Profiles	1.0	1.33444
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.71047
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.57174
TRABD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70291
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8563-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02248
SYNGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42307
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56732
CHAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63885
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99898
ZNF770	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52011
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEURL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87683
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.845541
UBE2I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58814
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38197
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955669
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63265
FAU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03947
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.19514
LC1F	CCLE Cell Line Gene CNV Profiles	1.0	1.51181
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6365
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37465
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
GTEX-RU72-1026-SM-46MUG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976039
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.03771
APPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79043
ZNHIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50359
ACD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7402
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891851
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911867
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29419
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tendon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SVBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72303
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4874
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0306
MAN1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7068
MIS18BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08338
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0822
Depressed Bipolar I Disorder	DisGeNET Gene-Disease Associations	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.79484
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873461
MKRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15339
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1809
domains	GeneRIF Biological Term Annotations	1.0	null
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69143
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ARHGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11693
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29912
Essential tremor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
PMC10245467-mmc3.pdf-162-ZNF98_ZNF98	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TNFAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92997
HBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60802
TIMM21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44181
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80608
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04041
GTEX-X5EB-1626-SM-4E3IV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12705
NSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74403
AM38	DepMap CRISPR Gene Dependency	1.0	8.33166
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847138
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
prostate_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.07549
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03065
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996454
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36345
RHOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92389
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54186
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07757
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.983271
intermediate stratum of r6Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1188
hsa-miR-1343	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21385
CDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4569
GTEX-T6MN-0426-SM-32PMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884155
Perturb_6957_KO_Ift88_SRP179473	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.63203
ARMCX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51071
colon	HPA Tissue Protein Expression Profiles	1.0	0.872026
medial parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01798
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.972397
CNTRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85191
GTEX-O5YW-0008-SM-4E3IE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80335
NCIH2081	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78791
HOXB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73266
TRIM24_knockout_298_GDS3087	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.8597
Sorsby's fundus dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.82915
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
TMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21365
FSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95183
GTEX-XV7Q-2526-SM-4BRV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831571
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971466
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847505
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7393
proteolysis	GO Biological Process Annotations 2015	1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24793
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39373
CYB5D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96507
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12134
GTEX-XUW1-1126-SM-4BONZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875788
NCIH650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42442
PARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10388
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5250-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26985
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08742
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCCSUP	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85072
JcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23644
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.918496
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
COL2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34989
ACAD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6861
IZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.829077
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-0226-SM-3NB1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11895
preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22346
EMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0466
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02469
Sarcoma_SARC_TCGA-DX-A2J1-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.8207
GTEX-NPJ7-1326-SM-3MJHO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27863
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16355
SKGT2	DepMap CRISPR Gene Dependency	1.0	2.02706
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94913
CENPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62373
MRPS18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38459
olfactory bulb, principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15761
CCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0324
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051747
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17991
Medial habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86261
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08949
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.866486
Vasculature-macrophage	Tabula Sapiens Gene-Cell Associations	1.0	6.53026
CHD1_02_187	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63227
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32422
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42031
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.75829
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959786
MDAMB231	DepMap CRISPR Gene Dependency	1.0	2.25171
dorsolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.868704
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.942552
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43024
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62N-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12673
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867652
Peptidase S1A, chymotrypsin-type	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.19236
ZNF787	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28503
GTEX-S33H-1326-SM-4AD6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851507
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.18169
Nonsyndromic deafness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
GPR137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9252
MLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41677
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02837
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.757359
BFAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36672
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20256
ATP5F1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32948
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.816
SAP18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6787
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12078
SNU5	CCLE Cell Line Gene Expression Profiles	1.0	1.3791
Major island of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05299
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18601
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04213
CL-34	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32953
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989337
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41852
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955239
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13947
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58943
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196199_0_v_1_zbtb20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24239
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ABHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80006
URB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.061
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01559
mantle zone of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00355
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6936
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04666
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71581
Pancreas	GTEx Tissue Gene Expression Profiles 2023	1.0	2.22279
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85569
GTEX-S4P3-1526-SM-3K2AV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11942
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41123
Acute Myeloid Leukemia_LAML_TCGA-AB-2874-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882577
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70322
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26901
Dorsal peduncular area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52604
ARPC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42862
pontine raphe nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55685
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23544
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.76258
LOVO	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.15314
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VJYA-0226-SM-4KL1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42315
UMUC9	DepMap CRISPR Gene Dependency	1.0	6.77751
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20865
APBB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75134
Dicarboxylic aminoaciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
intermediate stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72333
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NSUN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49516
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45657
laminin-12 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.505
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08268
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RBPJ	ChEA Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5955
CLIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00898
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050708
EIF3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23091
placenta_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.12727
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61076
preoptic alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25487
SMARCC1	ENCODE Transcription Factor Targets	1.0	null
GLYATL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60813
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Agranular insular area, ventral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23116
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2444	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34725
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41393
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-1026-SM-4KKZN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32597
intermediate stratum of LPrP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.391
ZC3H12D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61274
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERCC6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24832
ANKRD28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23586
MYOG	ENCODE Transcription Factor Targets	1.0	null
STRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57663
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SLR20	CCLE Cell Line Gene Expression Profiles	1.0	1.53188
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868523
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050615
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09065
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.7229
CFAP418	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59753
TSPAN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56498
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DFCI024	CCLE Cell Line Gene Expression Profiles	1.0	1.56922
Midbrain reticular nucleus, retrorubral area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26625
intermediate stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07848
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60946
GTEX-U8XE-0008-SM-4E3K4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39626
embryoday8.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.25061
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.694404
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48679
NMUR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88834
Subparafascicular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16533
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.80928
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.835552
EXOSC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40101
Paraventricular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3021
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81915
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970948
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2830-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
precentral gyrus, right, bank of the precentral sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.979832
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
RBM45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65375
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.889124
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98264
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-VJYA-0526-SM-4KL1R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33977
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11334
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC35F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6209
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09728
HMG20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91977
FEZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46448
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.257
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040007
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZIK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29788
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.70788
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.785222
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.02225
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24951
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12814
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.66105
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A439-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4844-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05254
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21307
hsa-miR-532-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
TAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28268
TTPAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30293
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984001
Peptidase S1A, polyserase-2	InterPro Predicted Protein Domain Annotations	1.0	null
Adrenocortical carcinoma_ACC_TCGA-P6-A5OF-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FASTKD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52118
GTEX-Q734-1826-SM-2I3EL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81934
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5679-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNB75	DepMap CRISPR Gene Dependency	1.0	4.33545
GTEX-PWOO-0726-SM-2I3EB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930558
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
Bipolar disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.14882
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894438
TSPYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53195
IGFBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52666
DPPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67047
GTEX-TML8-2026-SM-32QOP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15661
NUP133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35876
GSE157049,GSE157051_7_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10743
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64264
YY1-22570637-MALME-3M-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
FXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68729
RBBP5	ENCODE Transcription Factor Targets	1.0	null
hESC_Derived_CD184+_Endoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.843137
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964252
HTRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64328
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83T-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845773
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898435
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
LCLC103H	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50514
GTEX-WI4N-1126-SM-3LK7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45283
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4607-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.3061
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.39962
embryoday10.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.92395
PRKAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97211
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.60662
HL60	Achilles Cell Line Gene Essentiality Profiles	1.0	1.99941
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939239
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
synovium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2866-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.02794
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
Cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HCST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16578
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49974
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11415
EDARADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95107
BATF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93292
TOR1AIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93333
Taenia tecta, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67931
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.9433
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16767
SYNCRIP_OE_GDS3186_84_mouse_wild type 129 mouse retina	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A4P8-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEM	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01501
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966406
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3556
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28657
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MIEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89397
GSE126402_4_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUZ12	ChEA Transcription Factor Targets	1.0	null
GTEX-OIZH-1326-SM-3NB1H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895584
VIPAS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30656
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5539
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21385
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33722
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ChIP_H3K27me3_18600261_mouseWholeBrain	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039751
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal part of m1A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16207
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF	ENCODE Transcription Factor Targets	1.0	null
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78109
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33591
bed nucleus of the external capsule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33437
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Synovium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51433
GTEX-X4LF-1726-SM-3NMBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71629
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25254
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.4777
LAMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12232
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07373
ZNF621	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24017
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LEUTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78984
GTEX-XPT6-0008-SM-4B64Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871773
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.866262
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEP55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82587
SNU1033	DepMap CRISPR Gene Dependency	1.0	3.53644
ZNF839	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6601
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90778
heart muscle	HPA Tissue Protein Expression Profiles	1.0	1.19514
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7617
FAAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4165
PTPRU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59787
ECC12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01694
heart_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.873527
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32927
REEP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96021
terminal paraventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17528
KLF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86836
smallintestine_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.21744
RNF123	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.485
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45835
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.927464
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0898
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SKCO1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01106
periventricular stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.96078
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17919
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.31664
HCC15	CCLE Cell Line Gene Expression Profiles	1.0	2.02489
LEPROTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95306
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58215
RICTOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52878
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214576
ventral paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28486
Neurohemal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.222
Pseudomyxoma peritonei	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
septopallidal transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59847
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40746
BEND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39567
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.892054
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.853093
SARS-CoV MA15_Day4-C57BL-6_None_GSE40824	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.6233
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8596
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RBM25_02_166	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.71272
GFI1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92993
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3819
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73994
GTEX-SUCS-1826-SM-32PM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01449
PMC6021240-oncotarget-09-27605-s009.xlsx-Sheet1-STAT5A_STAT5A	Rummagene Transcription Factor Associations 2026	1.0	null
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32895
Microvillus membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14594
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06075
PPARG	ChEA Transcription Factor Targets	1.0	null
CUL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72991
NDUFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96188
VAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08002
dorsal septopreoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43979
GTEX-WFON-1226-SM-3TW8F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901238
YY1	ChEA Transcription Factor Targets	1.0	null
intermediate stratum of m2B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0809
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4874
SEC11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07054
periventricular stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56313
RPSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32493
IGHMBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92427
HOOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78071
NUDT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22283
RPL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73105
GABPA	ENCODE Transcription Factor Targets	1.0	null
lateral part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23059
H3K27me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ABI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34139
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
COMMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11808
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.825294
GSE180377_2_v_1_lipa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11923
Sarcoma_SARC_TCGA-3B-A9HO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EXTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34479
GTEX-P78B-0926-SM-2I5FA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14736
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	65.038
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF15_02_140	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.47393
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10299
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53334
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65996
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47648
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02528
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044735
TMEM151B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62882
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19751
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06569
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54063
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68C-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.7909
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16344
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.617
ATP5MK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1848
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.354422
FU97	CCLE Cell Line Gene CNV Profiles	1.0	1.42794
ZDHHC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9615
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNOS-0726-SM-4DM5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44134
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.938525
CEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09549
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	2.31936
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0713
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2836
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2043
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0326-SM-4E3K2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56427
SNU685	CCLE Cell Line Gene Expression Profiles	-1.0	-2.43887
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XUJ4-2526-SM-4BOO4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58273
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51926
DKK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60719
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.699509
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.824312
EIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88651
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1103
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28402
ZNF705A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56583
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02921
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.93261
CYBC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95826
Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMIM30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71257
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RANGRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41423
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.869614
GPATCH11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86556
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05492
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.855911
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75471
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
NEUROG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39851
TNFSF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69167
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1584
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-1826-SM-4BOOU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977676
HMGN3	ENCODE Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6683-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27679
ventrolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4041
SNU601	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45852
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.3508
VMRCRCW	CCLE Cell Line Gene CNV Profiles	1.0	1.39596
PDE6D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85547
CCLFPEDS0003T	DepMap CRISPR Gene Dependency	1.0	4.04634
H3C13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42201
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-hgnc_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867585
Parahippocampal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.687
TRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49006
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KP4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40588
CFL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35903
Primary somatosensory area, unassigned	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02747
RFX5	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YAPC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
pituitary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.26495
HCC827GR5	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.12325
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.70639
F5	CCLE Cell Line Gene Expression Profiles	1.0	1.87161
GTEX-OXRN-0226-SM-2I5EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42952
r5 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13921
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24502
SIN3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47431
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATG16L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66705
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9403
ZNF605	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18337
Lung adenocarcinoma_LUAD_TCGA-86-8585-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59047
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845242
CLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05811
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21079
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53921
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20619
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24862
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62548
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.30248
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.20342
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14702
SSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78645
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050776
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PABPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72263
GPATCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23139
Red nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29101
Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12410147-NIHMS2099518-supplement-5.xlsx-z-scores_E4DEG_DGATiLPS_vs_LPS-Z-scores_for_genes_differentially_expressed_when_comparing_DGATi_LPS_treatment_to_LPS_alone_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79612
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17946
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65437
Learning Disorders	CTD Gene-Disease Associations	1.0	1.02299
GTEX-OIZH-0226-SM-2YUMH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00656
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
JHH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4686
GTEX-XYKS-1826-SM-4E3JV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01643
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.22656
NSMCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74991
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.34639
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834538
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980026
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.2169
TBX2-35687133-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18141
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873157
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GP1BA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30286
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.2128
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	1.0	4.38834
8-MG-BA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11118
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3695
MRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67887
MED13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79345
PMC10256799-41598_2023_36660_MOESM3_ESM.pdf-1-DLX6_DLX6	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
proteinaceous extracellular matrix	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844619
TAGLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25331
U118MG	CCLE Cell Line Gene Expression Profiles	-1.0	-2.23183
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APOBEC3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3924
GTEX-UPK5-1826-SM-3GAEB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56916
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45835
GSE157049,GSE157051_6_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22846
GTEX-U4B1-0226-SM-4DXU8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09516
ANKRD24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75204
EZH2	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I4-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	2.09381
OTUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46241
FBXO10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61347
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.15891
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7419
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z5-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71664
ZNF592	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58352
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899121
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.860624
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20866
GTEX-WHWD-0826-SM-3LK6R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61646
GSE123887,GSE123888_3_v_1_hpgd_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58903
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13229
LDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52993
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03936
LNZ308	CCLE Cell Line Gene Expression Profiles	1.0	1.71438
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14415
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Spinal nucleus of the trigeminal, oral part, caudal dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13059
RSF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
GTEX-RNOR-0008-SM-48FEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0372
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240896,GSE240899_5_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NEFH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44261
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04228
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12541
TRIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31967
Nucleus y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08864
Sexine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.578
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.51823
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75333
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6191
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUS-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.73249
ABCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57807
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30112
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5455
FLOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29663
IER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35403
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48919
Olfactory tubercle	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08493
GSE247159_8_v_3_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26179
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.84897
MYOZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3112
NPIPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36109
TBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61659
SYCE1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16282
GTEX-OHPN-0008-SM-4E3HW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8427
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80881
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28346
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30225
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60749
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846247
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28238
NADK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07369
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20965
NINJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87562
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868315
rostral interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34946
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07054
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06096
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01353
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Q7-1426-SM-3K2B9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982816
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2088
SPIN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24861
496100430_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.091
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840514
Hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.095
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.0368
MPRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38063
Liver hepatocellular carcinoma_LIHC_TCGA-NI-A8LF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964564
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12441
MDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10535
substantia innominata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.00951
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.80511
hmc1	HPA Cell Line Gene Expression Profiles	1.0	1.08393
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.913926
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964421
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.44457
WDR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22377
HCC827GR5	CCLE Cell Line Gene Expression Profiles	1.0	2.57956
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
Taenia tecta, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6954
RERFLCSQ1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34367
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSS	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73637
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10655
RL	DepMap CRISPR Gene Dependency	1.0	3.01256
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15811
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4225-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.7743
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2666
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MI-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-1326-SM-4LVMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2442
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FARSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34618
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.30061
endometrium	HPA Tissue Gene Expression Profiles	-1.0	-1.23781
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2999
C11orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17346
ATP6AP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04422
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16086
Islands of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71734
external segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887482
OS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06578
mantle zone of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15812
ATF7IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81306
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.88225
second (ventral) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43979
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10296
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13351
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07385
NO-10	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27544
Dorsal peduncular area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27382
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2943
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53279
SCAND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29496
pararubral nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30616
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886118
Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H810	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31003
CCNT2	ENCODE Transcription Factor Targets	1.0	null
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46366
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01797
PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
Mitotic arrest phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08949
PPP2R5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01238
MAP2K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00686
ZNF263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6273
GTEX-QDT8-0226-SM-32PL4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11134
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.73916
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.44537
periventricular stratum of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30887
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PSEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42544
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45956
Perturb_7667_KD_IMP2_DRP003316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.54926
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11345
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSRNP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52489
F2RL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36343
IFI16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87871
AZIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0888
GTEX-WRHK-1726-SM-3MJFK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24101
PIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75782
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	7.52271
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.98666
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10547
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22013
TC-YIK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13918
ASNSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66937
Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LARP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12734
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.546885
SHSY5Y	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62481
NID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87377
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04373
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.767478
DENND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0771
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5435
superficial stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81863
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7737
PNRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19149
RHNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33069
VCY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52806
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	3.00159
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.00147
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01744
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
MTMR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29463
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34891
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CG-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92684
NRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14435
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1142
CADOES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57725
ZNF396	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75907
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28615
ZNF449	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99048
MGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1258
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.864554
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.53634
inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44324
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MPHOSPH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00714
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.68617
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828849
BCL2L10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84519
brain_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.191
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56611
ZNF282	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64137
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954451
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34179
RMUGS	CCLE Cell Line Gene Expression Profiles	1.0	1.56709
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896468
endometrium_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.856055
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09995
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF648	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27633
SRF	ChEA Transcription Factor Targets	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01747
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05492
NECAB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5742
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07258
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBK-0226-SM-2YUMF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48794
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGFBR1_activemutant_291_GSE14523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.44655
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56837
GPR176	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36447
LONP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45774
TRAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50551
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01628
Lung adenocarcinoma_LUAD_TCGA-MP-A4T7-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Graves' disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
lingual gyrus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.902602
GTEX-U4B1-1726-SM-3DB9F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966908
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55699
BTG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80699
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.3792
primary motor cortex (area M1, area 4)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.914699
MAN2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1194
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869222
COLO680N	DepMap CRISPR Gene Dependency	1.0	9.76675
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
RAB20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53942
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04292
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-ensembl_gene_id_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
RAB3A_Mutation - D77G point mutation_GDS2483_698_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13062
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47865
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OSC20	DepMap CRISPR Gene Dependency	1.0	4.22756
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964564
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04905
ZNF821	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.78747
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
peptidase activity	GO Molecular Function Annotations 2015	1.0	null
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.841504
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09318
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.866486
H3K27me3_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.44995
RAC3-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0347
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865949
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74559
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.97396
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP4K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40374
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01628
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8651
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
FLI1-21867929-CD8-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CPSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56669
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21994
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25014
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF451	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63515
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44626
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96275
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890417
Semicircular canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12569
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26964
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25962
Brain Lower Grade Glioma_LGG_TCGA-HT-A74O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLAIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69929
HS939-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
TBC1D25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76973
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.169604
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Olfactory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35425
COL9A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44012
AADAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33298
GTEX-WY7C-0926-SM-3NB34	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18683
BRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37721
secreted	GeneRIF Biological Term Annotations	1.0	null
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28386
RPL37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13134
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.865448
PHF8	ENCODE Transcription Factor Targets	1.0	null
mantle zone of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15987
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.29932
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050708
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-GeneID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rectum_8d	HPA Tissue Sample Gene Expression Profiles	1.0	0.924645
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SPTBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20678
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199034_1_v_0_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
revealed	GeneRIF Biological Term Annotations	1.0	null
P4HB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0924
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30704
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE520	DepMap CRISPR Gene Dependency	1.0	6.70295
Sarcoma_SARC_TCGA-DX-A3U5-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
DPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36374
INTS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69022
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31003
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898817
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.10416
GTEX-SIU7-0226-SM-4BRX2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.8642
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34329
BICR31	CCLE Cell Line Gene CNV Profiles	1.0	1.72477
GTEX-XUJ4-1726-SM-4BONW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44086
NUCKS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.316
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03466
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFATC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03078
VBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55819
PMC8582123-13073_2021_996_MOESM4_ESM.xlsx-SATB1-HIT_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85965
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12661
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.851091
PWWP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62611
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
MMP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41682
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.21076
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38751
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44911
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5551-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBLCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53535
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07528
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XAJ8-0926-SM-47JXZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05815
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.76553
G28T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.857227
Folic Acid	CTD Gene-Chemical Interactions	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00595
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15005
GSE139948_3_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.05239
HNF4A-19761587-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00179
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2816
HK2	CCLE Cell Line Gene Expression Profiles	1.0	1.97624
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03121
ELF1	ENCODE Transcription Factor Targets	1.0	null
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15098
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13391
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.5833
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06686
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35196
SNU886	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80612
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895391
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35925
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
first (dorsal) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00486
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89289
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99339
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26013
PLPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1005
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00594
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85J-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DPPA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95993
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5047
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49406
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02539
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72333
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
23132/87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.936989
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.19755
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HPBALL	CCLE Cell Line Gene CNV Profiles	-1.0	-2.11631
GATA4_KO_GDS3486_483_mouse_jejunum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852042
PMC3046820-supp_db10-1270_DB101270SupplementaryData2.xls-Table_2S_Adioose_AA_vs_EA-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4722
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4915
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31383
RHOXF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10149
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XL-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SCAPER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34021
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873881
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70862
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25047
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40077
COLO775	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98346
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16482
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0151
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28717
inner CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08768
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.15225
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.897391
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4035
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AQP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50822
MPV17L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68554
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955239
C14orf93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86564
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
UBALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17344
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60885
GSE264621_1_v_3_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC25A39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15243
Cochlear hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.279
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890138
GTEX-WY7C-2326-SM-3NB2U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986563
Lung adenocarcinoma_LUAD_TCGA-44-2668-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
GTEX-XQ8I-1426-SM-4BOPW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00444
GSE208435_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.944894
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.70793
NCIH526	DepMap CRISPR Gene Dependency	1.0	3.78559
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23533
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.868335
CD79B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90974
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.43605
ANO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39303
TFAP2C_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6V9-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5541
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.996876
NY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.237
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.38029
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.985828
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.5503
ONECUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07625
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45835
HELB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56073
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02436
hand, foot and mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
synovial tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57986
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990792
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20318
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0851
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LN18	DepMap CRISPR Gene Dependency	1.0	2.08979
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
PSMD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2848
GSE149880_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85652
dorsal paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0167
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.72699
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09146
ZNF586	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13583
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.978892
RB1_KD_GSE50532_659_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H2BC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57006
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
Trypsin-like cysteine/serine peptidase domain	InterPro Predicted Protein Domain Annotations	1.0	null
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9209
EEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59142
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-2578-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2066	CCLE Cell Line Gene CNV Profiles	-1.0	-2.66329
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YKG1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.43748
HNF4A	ChEA Transcription Factor Targets	1.0	null
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.87439
primary auditory cortex (core)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37158
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.995137
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.961435
three	GeneRIF Biological Term Annotations	1.0	null
OGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61438
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03121
Stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37517
FOSL2	ENCODE Transcription Factor Targets	1.0	null
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0881
ZEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05939
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP5F1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88918
TMBIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82525
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NGLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69444
DAN-G	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE234155_7_v_1_nfix_human	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8865
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.58585
connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.13633
medial subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08653
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4201
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15987
SPI1	ENCODE Transcription Factor Targets	1.0	null
Main olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.51231
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60766
Perturb_7668_KD_IMP3_DRP003316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.24298
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82811
GTEX-V955-1226-SM-4JBI9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935279
A1207	Achilles Cell Line Gene Essentiality Profiles	1.0	1.29036
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EXOSC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27937
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18494
TMEM198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99468
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6004
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95518
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20658
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1452
ARID3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95479
preopto-hypothalamic band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06412
Water vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.633
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.76339
NSL complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.993
layer 3 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26551
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4Q7-1626-SM-3K2AE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12015
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posttranslational	GeneRIF Biological Term Annotations	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.966082
NLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63227
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.82043
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21658
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75668
cell part	GO Cellular Component Annotations 2015	1.0	null
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845543
Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01405
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PURB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30323
MCAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06263
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16967
Lung squamous cell carcinoma_LUSC_TCGA-21-1071-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.846028
Pollen wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.445
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
r6 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0793
SPI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.7412
medial part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14453
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13896
GTEX-O5YV-0426-SM-3LK66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21937
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87073
SIX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91708
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885102
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7657_KD_CTCF_SRP128556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.08458
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.958651
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72432
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23258
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16927
HCT116	Achilles Cell Line Gene Essentiality Profiles	1.0	1.5095
Synaptic ribbon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
protease	GeneRIF Biological Term Annotations	1.0	null
NCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54547
GTEX-V1D1-0826-SM-3P5ZA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36226
GTEX-X5EB-0426-SM-46MVY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27574
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4688
NFIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85895
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
UBLC1	DepMap CRISPR Gene Dependency	1.0	4.34704
abnormal auditory brainstem response	MGI Mouse Phenotype Associations 2023	1.0	null
RPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3174
GTEX-WZTO-1126-SM-3NM93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0344
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21826
SUZ12_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGROV1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.23815
shell of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30772
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.95017
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19999
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06358
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.19292
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.883274
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885784
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7231
SYNGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28487
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913111
superior frontal gyrus, right, medial bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.856499
RNF113A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65834
YY1	ENCODE Transcription Factor Targets	1.0	null
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5932
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06695
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47349
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898243
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.12272
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9685
ZSCAN30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46486
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06251
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.936428
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
beta-N-acetylhexosaminidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
Mitral valve prolapse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
CCNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95316
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HE-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895391
Adrenocortical carcinoma_ACC_TCGA-PA-A5YG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
postcentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98425
ZBTB37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0482
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09243
RAB42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35251
CCDC69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99977
BARHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43048
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A896-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02723
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.43091
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B3GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1507
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.857676
Sarcoma_SARC_TCGA-DX-A3LU-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039168
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
part	GeneRIF Biological Term Annotations	1.0	null
GTEX-QCQG-1826-SM-2S1P2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3553
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057818
GTEX-X5EB-0008-SM-46MU3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4801
serine-type peptidase activity	GO Molecular Function Annotations 2023	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.01475
SMC3	ENCODE Transcription Factor Targets	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.04276
mantle zone of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13635
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PARD6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76956
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25618
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36749
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.85599
hsa-miR-4516	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EFNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2899
GTEX-X88G-0226-SM-4GIE4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26341
GTEX-QLQW-1226-SM-2S1Q9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02614
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68548
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64483
hsa-miR-3136-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-0.85328
mechanisms	GeneRIF Biological Term Annotations	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.07549
Tectum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.769
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938152
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55775
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939591
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12448905-vlaf042_supplementary_data.pdf-4-CDX1_CDX1	Rummagene Transcription Factor Associations 2026	1.0	null
RRP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58443
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
hair-cell stereocilium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17959
Synovial tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44Q-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.31444
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.064
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38391
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACHN	CCLE Cell Line Gene CNV Profiles	1.0	1.50179
NCIH1648	DepMap CRISPR Gene Dependency	1.0	2.07583
496100502_TCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32332
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06727
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4167-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55G-2426-SM-2TC5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35664
GTEX-WVLH-0226-SM-3MJG6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17737
JUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43524
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.9635
MAX	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83574
GTEX-Q734-0126-SM-48U1E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13517
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41497
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18907
ZNF346	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40442
periventricular stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78568
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04215
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55806
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MFSD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66015
KLKB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21075
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
GCIY	CCLE Cell Line Gene CNV Profiles	1.0	1.33899
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02829
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
periventricular stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15759
HK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26619
Perturb_11104_KO_Tsc1_SRP219943	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.18747
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	3.97838
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09089
spleen_3b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.886933
CMAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9379
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SFPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89495
CDCA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39086
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17103
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24916
Dorsal peduncular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82675
transverse gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36396
MARCKSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21782
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.942552
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.932323
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area, ventrolateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17763
layer 2 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02219
GTEX-W5X1-0008-SM-4LMKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993865
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18186
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHPG-0626-SM-3NMBD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06429
ORAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58996
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87743
extracellular matrix	GO Cellular Component Annotations 2015	1.0	null
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8335
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LN215	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.27421
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ADD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.61691
SMARCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07451
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.722
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5633
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-2K-A9WE-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828765
CORL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61379
GTEX-V1D1-0326-SM-4JBIY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.57791
STK40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9586
COL6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98399
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.999161
abnormal auditory brainstem response	IMPC Knockout Mouse Phenotypes	1.0	null
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-genename_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
NPIPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50428
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33726
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75458
Mesothelioma_MESO_TCGA-TS-A7P6-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06153
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24352
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89956
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876504
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07046
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.905063
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mouth	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904625
GTEX-Q2AH-0626-SM-48TZJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5573
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55359
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GOLGA8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27963
Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1249
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29037
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36572
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7SE-0826-SM-4AT4D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18155
SRF-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Medial preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40377
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840514
r2 part of nucleus subcoeruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06004
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59862
Microbody lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.974175
MYC	ENCODE Transcription Factor Targets	1.0	null
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.196
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZNF558	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23438
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71581
H3K27me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883435
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.942165
SNU668	DepMap CRISPR Gene Dependency	1.0	3.54063
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38879
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83V-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.05471
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.721941
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Taenia tecta, ventral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12629
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42467
NUDT16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57288
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.3239
GSE126762_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45132
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47592
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Peptidase S1, trypsin family, active site	InterPro Predicted Protein Domain Annotations	1.0	null
ZNF546	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76627
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96382
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.866486
B4GALT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6495
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40407
SOX3-22085726-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30716
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54481
RCOR1	ENCODE Transcription Factor Targets	1.0	null
LRRC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52963
POLR2A	ENCODE Transcription Factor Targets	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
KARPAS422	DepMap CRISPR Gene Dependency	1.0	2.72888
DCHS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45654
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32467
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75881
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11276
SHISA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4056
ESRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62265
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13025
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
PcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15539
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21385
precentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09243
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06251
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.22539
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
serine-type peptidase activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869618
BRD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55349
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67378
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.73916
MTMR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73603
NR1H4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61581
RPA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.75851
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.945751
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Corpus albicans	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
PKNOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56328
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21778
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65309
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Myasthenia gravis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
TAS2R5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88722
PMC8190596-mmc2.xlsx-ETV6_mut-ETV6_mut_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8007-11A-01R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNFRSF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3504
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60047
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2996
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.828711
KATNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37009
PK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80901
H3K27me3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UGT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07234
AGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95729
EYA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79468
GTEX-X4LF-0526-SM-3NMB6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16967
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP1	ChEA Transcription Factor Targets	1.0	null
Perturb_2897_KO_Il33_SRP076391	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.74187
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
processing	GeneRIF Biological Term Annotations	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999335
PSMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1513
DLGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20772
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18023
GTEX-XGQ4-2226-SM-4AT4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22348
Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.958275
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.937947
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LS123	CCLE Cell Line Gene CNV Profiles	1.0	1.96003
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33868
FLYWCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98809
DNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95115
PCDH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01604
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00993
habenula (old epithalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60763
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36196
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4153
GTEX-WK11-0526-SM-3NB3O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841349
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15322
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51F-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NLRP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97114
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
FAM118B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32706
GTEX-SN8G-0226-SM-4DM6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12481
TRMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.93359
GTEX-PLZ5-0826-SM-3P5ZW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13664
PITX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81416
GTEX-SUCS-0626-SM-32PM5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39622
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
SART3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8151
tongue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NHLRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20928
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CDK8_knockdown_130_GSE30816	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.22796
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16373
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.58088
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0525
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.922589
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37854
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1998
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.57276
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10648
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08636
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-2.04406
SNRPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69454
GTEX-S341-0126-SM-4AD64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12004
mantle zone of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43651
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887227
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TMTC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68082
GTEX-WL46-0326-SM-3LK6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89894
diagonal part of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13432
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.86823
GSE126402_4_v_0_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11496
Perturb_7879_KD_EXOSC3_SRP266190	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.95782
SLC5A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39772
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29105
LBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56337
TSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62746
AGPAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.371
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.70315
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U9-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.963858
CDK20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78344
Autoimmune disease of endocrine system	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.986
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
NUDT16L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24594
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28318
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20644
NCIH322	CCLE Cell Line Gene CNV Profiles	1.0	2.11211
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08949
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28951
small intestine	HPA Tissue Gene Expression Profiles	1.0	1.07277
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16297
CAMTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32764
GTEX-Q734-0826-SM-48U1G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09712
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75851
RVH421SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.91808
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4554
PARP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.968066
LIN7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56587
BPH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00958
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28498
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08855
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941358
PRR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44314
KCTD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33987
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35794
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.930042
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3729
CHST15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03008
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	2.55905
serine-type endopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOV10L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36432
fat_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.20399
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19306
MOLT-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF84	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56812
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-1.05274
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PLZ5-1626-SM-3NB21	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98936
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11931
TM9SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34906
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980687
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896401
HOXB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74055
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.19514
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82341
P2RX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83389
GABBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50826
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSG-2426-SM-4KKZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0008
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.34
GTEX-UPK5-2126-SM-4JBJK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8572
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.3078
CALM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98828
H4C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85171
ASF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03153
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RALBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18362
HCC1897	CCLE Cell Line Gene Expression Profiles	1.0	1.48847
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35387
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.28714
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.1014
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
GTEX-X3Y1-2026-SM-3P5YM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20878
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.05274
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31084
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12216
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3787
PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-external_gene_name_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
MED12L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38686
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Episodic kinesigenic dyskinesia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.98
EW8	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.27071
Outer hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.338
KIDINS220	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24184
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.33698
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828765
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03538
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1048
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1903
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27643
INPP5F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93482
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74122
TAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04603
Accessory olfactory bulb, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81544
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0526-SM-4DXTH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60405
PROCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16111
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.13
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PANC0327	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56641
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE157050,GSE157051_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MIDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76037
GTEX-SNOS-1426-SM-32PLY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00614
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03121
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.72977
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32255
GTEX-RTLS-0426-SM-2TF5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11985
CTH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15237
HNF4A-19761587-HUMAN INTESTINAL CELL LINE CACO-2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.526
RAD51B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82938
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4483
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7097
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5758
KYSE-220	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874972
GSE214823,GSE214824_5_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43687
NCI-H322M	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0561
mantle zone of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60705
Peroxisomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.552
adipose tissue	GTEx Tissue Gene Expression Profiles	1.0	0.828661
SP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.979133
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOSL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMRM-1726-SM-2S1QG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17321
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AGS	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18526
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.61849
ELAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17023
RPL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4122
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
DOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58867
serine-type peptidase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871987
Usher syndrome type 2A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29935
GTEX-UJHI-1626-SM-3DB9A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88042
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03121
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47592
SREBF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Isolated sulfite oxidase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066861
MAST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37231
YY1-22570637-MALME-3M-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93164
DMS-273	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ABAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96371
ARSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0095
anterior paraventricular nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48711
MBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.37547
MYO5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86524
PMC7825356-8844261.f3.docx-199-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.75239
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IER5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0834
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SELENOO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48604
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10888
Lung squamous cell carcinoma_LUSC_TCGA-77-7465-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Infralimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08382
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96732
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2598
Central amygdalar nucleus, capsular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06256
ZER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41512
CAOV3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.49709
MYC-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TE-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942316
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62409
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23176
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1555
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59455
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SRF-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
skmel30	HPA Cell Line Gene Expression Profiles	-1.0	-1.78551
Infralimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54084
CHCHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40937
Perturb_7658_KD_CTCF_SRP128556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
Perturb_2391_KD_PRKDC_SRP308699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.13939
Sarcoma_SARC_TCGA-DX-A8BN-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844063
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
PRPF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49453
Taenia tecta, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85993
Exine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.481
RND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3411
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.25549
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.5899
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5613
CDS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64375
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23723
medial part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40268
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GNG12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54183
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.88538
NCOR-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21841
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FASTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18905
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20183
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Vitelline membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19688
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19312
GDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49166
PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-hREPC_AND_AF_MSC_AND_fMSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SNU475	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43454
UCHL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91827
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51398
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.16331
SKPNDW	DepMap CRISPR Gene Dependency	1.0	2.7102
Rad17 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
GTEX-X3Y1-0626-SM-3P5YS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36358
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4541
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5794
LIPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54963
ZNF587	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0891
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25814
GTEX-PX3G-3026-SM-48TZR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17274
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BT549	CCLE Cell Line Gene Expression Profiles	1.0	1.6794
ZNF311	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98915
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972804
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03264
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41452
USH2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.896
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.990583
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63558
ZNF559	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45866
GSE209598_1_v_2_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
septopallidal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19382
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.802896
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SP-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96823
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19027
MTERF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33149
Nucleus of reunions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01072
HNT-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07619
COL26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51903
periventricular stratum of JcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23644
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73E-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38291
RNF149	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5899
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^3_None_GSE43302	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.38706
PCYOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.37162
PRELID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11171
NCI-H1299	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SEMA5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32533
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856296
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TYW3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89997
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.39058
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13303
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16777
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4384
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFKBIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50366
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DV-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08382
ELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76532
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.92228
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895552
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-THP-1_MLL-AF9_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.931941
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11071
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19723
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911898
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13635
RAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43237
Orbital area, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06105
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.2083
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50218
CELF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74731
RADX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30539
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GNL3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60619
DCAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58576
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.4649
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8XE-0826-SM-4E3J1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941653
RPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40092
MSANTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17405
KDM4A	ENCODE Transcription Factor Targets	1.0	null
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03503
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77403
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
k562	HPA Cell Line Gene Expression Profiles	-1.0	-0.916129
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71362
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06174
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.85383
Subgeniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07275
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.987799
496100646_TCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43848
preoptic telencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27382
integral	GeneRIF Biological Term Annotations	1.0	null
GTEX-P4PP-3026-SM-3P61O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880189
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82759
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.868228
GTEX-O5YV-0526-SM-2I5GE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997168
F36P	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53902
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.19514
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TDOTT	DepMap CRISPR Gene Dependency	1.0	2.25875
KIAA1143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43794
SF172	CCLE Cell Line Gene Expression Profiles	1.0	1.66955
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308251
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01049
ZNF143	ENCODE Transcription Factor Targets	1.0	null
496100522_PCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01697
FOXD4L6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47062
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0232
NCIH292	CCLE Cell Line Gene Expression Profiles	-1.0	-2.27723
DVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11516
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25538
ICAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30406
PAX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52957
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880086
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20784
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64145
GTEX-WYVS-2526-SM-3NMAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8287
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.72653
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
Epithalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52941
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.142
SCARA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80312
serine-type endopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4585
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.16866
vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF708	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64904
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1338
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03876
8305C	DepMap CRISPR Gene Dependency	1.0	2.03507
ZNF852	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42834
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.62166
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Choline	CTD Gene-Chemical Interactions	1.0	null
polyserase2	GeneRIF Biological Term Annotations	1.0	null
NAMALWA	CCLE Cell Line Gene Expression Profiles	-1.0	-2.46448
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KK-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2932-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050994
Heart	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
SNRPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23911
septal organ	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07412
lateral preoptic nucleus, PO2 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08041
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.854896
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS746T	DepMap CRISPR Gene Dependency	1.0	2.45149
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12532
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880086
CHD2	ENCODE Transcription Factor Targets	1.0	null
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057445
Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BLCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.63571
proteinaceous extracellular matrix	GO Cellular Component Annotations 2015	1.0	null
GTEX-QCQG-1526-SM-48U25	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09215
ZNF189	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32581
MTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45037
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
496100482_PCx_no dementia_TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56414
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.32563
TEAD4	ChEA Transcription Factor Targets	1.0	null
AGPAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80033
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JI-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
L3MBTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29162
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44177
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16344
RPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48794
Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052031
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSV-A2_24Hour-B6.129PF1_J_None_GSE18170	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.73521
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894194
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68751
cingulate gyrus, retrosplenial part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25595
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.27599
RNF170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.41373
PMC10794847-mmc5.xlsx-PIAS1_KD_up-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OLIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23616
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054253
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911141
RACK7-27058665-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13568
Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91629
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43971
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2C	ENCODE Transcription Factor Targets	1.0	null
GTEX-X638-0008-SM-47JZ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07982
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
RPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32931
GTEX-XMK1-0008-SM-4GICF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897642
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.546885
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945906
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02281
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4483	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
TMEM265	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64744
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941261
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chain	GeneRIF Biological Term Annotations	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01665
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14219
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ventral pallium	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51406
PSME4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44241
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral tuberal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0415
H2BK120ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEx Vagina 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-2.99701
PMC11836325-41467_2025_56634_MOESM8_ESM.xlsx-gene_table_NGS5844-Supplementary_Data_6_Gene_targets_lost_in_resistant_cells_upon_FOSL1_knockdown_and_their_corresponding_hallmark_pathway_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.917849
Dorsal peduncular area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75458
TRAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32787
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1404
GTEX-XUZC-1826-SM-4BRVO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15519
SURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62805
Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07807
intermediate stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28486
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.7778
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.46636
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.485
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16344
EMILIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85458
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35704
CHCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89432
Sarcoma_SARC_TCGA-K1-A6RU-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048405
Bipolar I disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.40048
GTEX-XUW1-0526-SM-4BOP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00961
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978085
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.05274
GPR50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73701
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12805
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.933617
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.92633
ANP32A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45257
C33A	DepMap CRISPR Gene Dependency	1.0	2.10279
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10469
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06189
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867468
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26247
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6448
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
ZNF680	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46246
MXI1	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69I-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225656_2_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32833
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88121
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3025
CDK8_knockdown_129_GSE30816	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.65256
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99901
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SSA3-0226-SM-32QPN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23739
AP1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20651
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09023
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05762
PLPP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51489
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60936
PRKCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26363
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0826-SM-48FCP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865883
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3577
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.7705
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22675
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46637
fusiform gyrus, right, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41521
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06008
NRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07055
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97206
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.863612
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.993673
estradiol_homo sapiens_gpl14550_gse35034	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.836968
Progressive supranuclear palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
NIBAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21541
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0923
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.839484
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16302
ZNF781	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87941
FAM20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30434
RPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73186
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76783
PC14	CCLE Cell Line Gene CNV Profiles	1.0	1.531
PDE7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91809
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.896212
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11217
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49219
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28128
NF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70707
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44309
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.11856
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25347
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.35234
PRPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82946
TAGLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64263
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27656
RPS24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02775
LEMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56512
substantia innominata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22199
GTEX-U3ZN-0426-SM-4DXSH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838524
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18784
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.940851
medial habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74103
HMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33177
GTEX-X3Y1-0926-SM-3P5YT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2849
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2081	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4686
Appendix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49393
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64421
Peptidase S1	InterPro Predicted Protein Domain Annotations	1.0	null
Main olfactory bulb, granule layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.60584
SMUG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6814
temporal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16237
UNC5CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55639
RNF130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19453
SLC27A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83132
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.867189
HCC4006	CCLE Cell Line Gene CNV Profiles	1.0	1.62561
AKT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86097
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.98983
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09203
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.333
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DFFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03951
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1944	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01559
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941358
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996262
GTEX-RM2N-1726-SM-2TF55	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83822
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82753
POLH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2335
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947065
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911911
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH854	CCLE Cell Line Gene CNV Profiles	1.0	1.76015
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866038
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23342
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PX-01A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15322
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31604
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46929
PER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39762
hsa-miR-4434	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.915853
LAMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11024
Midbrain raphe nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16659
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88489
NO10	DepMap CRISPR Gene Dependency	1.0	6.15796
IOMMLEE	CCLE Cell Line Gene Expression Profiles	1.0	1.8251
GMCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81351
PTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19911
GTEX-WY7C-2426-SM-3NB2V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01729
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.68692
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60162
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.0412
LRCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55599
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.4019
Anterior hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.52413
PDIA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52974
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872522
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26963
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.85348
METTL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25871
Main olfactory bulb, inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.10537
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30952
TJP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47579
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03989
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0133
Periventricular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09591
GTEX-P4QT-0226-SM-3LK68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72449
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09627
Lung squamous cell carcinoma_LUSC_TCGA-39-5030-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90098
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40271
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
PMC10794847-mmc6.xlsx-PIAS1_KD_up-Table_S5_Genes_differentially_expressed_with_PIAS1_knockdown_in_keratinocytes_cultured_in_the_differentiation_condition_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDVJ-1126-SM-48U1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93825
Mitochondrial creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232317
RERFGC1B	DepMap CRISPR Gene Dependency	1.0	2.58543
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01772
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49327
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LS1034	CCLE Cell Line Gene Expression Profiles	1.0	3.40795
Acute Myeloid Leukemia_LAML_TCGA-AB-2946-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.854875
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5145
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31717
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17512
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10883
superficial stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0995
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829311
RPS26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66306
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0837
CL11	DepMap CRISPR Gene Dependency	1.0	2.68759
GTEX-XAJ8-0226-SM-4GIB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859139
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896468
SQLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02354
CAL-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polyprotein	GeneRIF Biological Term Annotations	1.0	null
GTEX-X4XY-0008-SM-46MVL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00164
ANXA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66846
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.856735
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Taenia tecta, dorsal part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34946