association	dataset	threshold value	standardized value
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894417
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K54790089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03196
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24394
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.824838
MEIS1	ChEA Transcription Factor Targets	1.0	null
Rhinovirus infection_Nose_GSE11348	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.94772
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
FF-54-JC89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204903
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.513993
astrocytes	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.930052
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adipose tissue	GTEx Tissue Gene Expression Profiles	1.0	1.40879
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.95141
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02708
BRD-K81949875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73388
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
Nrd1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.875
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487266
CTCF_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K10232513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43016
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5796
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-87-EI21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329262
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70951
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27574
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.3733
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08578
PMC3189923-pone.0025991.s001.xlsx-CENPS-Unnamed_1_CENPS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52372795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25264
Pulse pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58379
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45619
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NABP1	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K40935524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65573
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU308	CCLE Cell Line Gene Expression Profiles	1.0	1.86004
BRD-K61209548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34007
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33108
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55372
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977086
BRD-K53379620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39629
BRD-K04358482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7232
CRCGN016_MCF10A.TP53.M_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2464
ATP6V1B2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937437
POLR1C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89515752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28356
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.931502
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31872
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.63074
BRD-K19776718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06015
AB-37-JM16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256049
GTEX-Q2AH-1726-SM-3NB2B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0947
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837632
HMGA1	Pathway Commons Protein-Protein Interactions	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.33938
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15532
BRD-K49401787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21498
MCF7_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129727
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.90629
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05085
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100518_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19307
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.962028
BRD-U51951544_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913326
spindle assembly checkpoint	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71531
vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
basomedial nucleus (accessory basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24893
regulation of sister chromatid segregation	GO Biological Process Annotations 2015	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69467
TFAP2C	ENCODE Transcription Factor Targets	1.0	null
GTEX-S341-1626-SM-3K2B8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0043
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40151
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320977
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960521
cellular_component	GO Cellular Component Annotations 2015	1.0	null
protein-containing complex assembly	GO Biological Process Annotations 2025	1.0	null
layer 6 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91276
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3076323-pone.0018064.s016.xls-MYCN_targets_Marson_GSE6007-Unnamed_1_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-468	GDSC Cell Line Gene Expression Profiles	1.0	1.99905
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6012
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30804
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81751970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12635
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315674
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54668
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Raji	GDSC Cell Line Gene Expression Profiles	1.0	1.4197
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.279
ANXA1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142763
basolateral amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58006
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16754
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.822
CRCGN015_HEPG2_48H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01529
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85734
BRD-K28814368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57089
BRD-K42385001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64352
hsa-miR-548i	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K62976536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2318
BRD-K18864235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46298
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5574
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27975
BRD-K12345912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30535
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.04221
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430942
BRD-A47706533_C1386_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K61287439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74165
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26251149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24082
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.28006
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960105
FSCN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28034484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75447
Perturb_8177_KD_RPS3A_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.72072
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.908888
BRD-K11652878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49443
methotrexate_homo sapiens_gpl571_gse9412	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.81777
chaperone-mediated protein complex assembly	GO Biological Process Annotations 2023	1.0	null
mantle zone of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03487
BXPC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05436
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500853
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.961885
Basal ganglia disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.74
BRD-K42138859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93446
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1817
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LYAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32719
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5888
MDAMB468	CCLE Cell Line Gene Expression Profiles	1.0	2.08768
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MD-86-UW46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267198
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Proteasome assembly chaperone 2, eukaryotic	InterPro Predicted Protein Domain Annotations	1.0	null
Dermatomyositis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30939
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K55896279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58323
CAL-85-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7018-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870436
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15946
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
proteasomes	GeneRIF Biological Term Annotations	1.0	null
Dinoprost	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.21
BRD-K25993054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16212
Perturb_7317_Mut_RNPS1_ERP130711	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.71934
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90745
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34124
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16128
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA3, stratum oriens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00486
TK1	Pathway Commons Protein-Protein Interactions	1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.894441
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYLK_knockdown_49_GSE14525	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.51155
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.09436
regulation of programmed cell death	GO Biological Process Annotations 2015	1.0	null
PSMA4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8594
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.432955
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349045
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39123
Nodular episcleritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
cell cycle process	GO Biological Process Annotations 2015	1.0	null
VPS28	Pathway Commons Protein-Protein Interactions	1.0	null
SIPA1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570556
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05381
basomedial amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09623
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67718
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GF-57-LR72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375026
BCLAF1_02_112	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58994
GTEX-X4XY-0926-SM-4E3JD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932457
Brain Lower Grade Glioma_LGG_TCGA-S9-A89Z-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TE4	CCLE Cell Line Gene CNV Profiles	1.0	1.53814
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32304
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12997
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05164
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06599
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877993
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS34	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49582
CRCGN015_MCF10A_48H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45986
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87397
Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5022_MFN2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523864
ChIP_MYC_19079543	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41677
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06547
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03324
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_2_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer 5 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02788
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.66154
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06886
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.7106
BRD-K67563379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9029
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.910295
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54526
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42468
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.830633
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of protein processing	GO Biological Process Annotations 2015	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43788
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.11583
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95628
negative regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thyroid gland disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.255
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888024
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.06892
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13028
H2BFS	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.03619
RALY	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.984337
BRD-K74015591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40103
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141852
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCAS	CCLE Cell Line Gene Expression Profiles	1.0	1.41996
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.862105
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5346
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61183
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	126.455
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.52157
mitotic spindle assembly checkpoint	GO Biological Process Annotations 2015	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15536
cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36087
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00591
Necrosis	CTD Gene-Disease Associations	1.0	1.48838
EB-09-JJ93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28527
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-1726-SM-3K2AX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12611
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96509
posteroventral (inferior) parietal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.01555
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19425
UBTFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28395
Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.52524
CRCGN016_MCF10A.WT.HP_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44809
PMC7617804-EMS206527-supplement-Document_S1__Figures_S1_S9_.pdf-1-KCMF1_KCMF1	Rummagene Transcription Factor Associations 2026	1.0	null
Tafamidis	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
GTEX-UPK5-1826-SM-3GAEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847954
TTLL12	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.943067
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
DA-83-IZ87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210417
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VPS37D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47375
BRD-K40685792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57288
GTEX-X261-0226-SM-3NMD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967944
TBP	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HQ-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34169251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30381
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01873
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473297
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.39927
SUDHL4	CCLE Cell Line Gene Expression Profiles	1.0	1.64414
TKT	Pathway Commons Protein-Protein Interactions	1.0	null
Familial cold autoinflammatory syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
RNF216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06045
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30396
BRD-K93927229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41372
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_DMAP1_20946988	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.2446
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APOBEC3C	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27891
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861076
CAL12T	CCLE Cell Line Gene CNV Profiles	-1.0	-2.33543
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03884
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21541
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47658
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.81244
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92365
CTCF_GM12870_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retromammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4411
BRD-K32751688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20428
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CBX3	ENCODE Transcription Factor Targets	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03806
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D2REFED4h_641_AR-D-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00837
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4621-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.04741
CORO1C	Pathway Commons Protein-Protein Interactions	1.0	null
IFNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00688372
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1419	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.50817
CRCGN013_HEPG2_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57184
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K90686530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5876
amygdalo-striatal transition	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23056
MYC-19079543-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.16545
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79758
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905215
Autoimmune disease of endocrine system	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.676
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223524
PFKL	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10343715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29108
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.34954
CADOES1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.137
A549_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137442
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040366
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09272
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12399
BRD-K94191869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0427
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990878
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43185
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06617
KPNSI9S	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50628
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50286
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289909
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16427
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40978
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02046
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-4J-AA1J-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-36-XE09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266474
BRD-K96164740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02563
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.841166
BRD-K81669067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52377
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93962
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.029647
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61605
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36002
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-MV-A51V-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.35363
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03881
cell cycle checkpoint	GO Biological Process Annotations 2015	1.0	null
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.502909
Jurkat	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.93074
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99496
GSE175787_8_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STXBP3	Pathway Commons Protein-Protein Interactions	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896117
GTEX-S33H-1126-SM-2XCB6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864549
AA-31-OE22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234418
OE19	CCLE Cell Line Gene CNV Profiles	1.0	2.19309
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10552
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224976
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	3.06128
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23337
BRD-K74933734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03786
negative regulation of proteolysis involved in cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1011
NCI-H747	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71114
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.531505
Retrosplenial area, lateral agranular part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06103
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23025
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039564
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00764
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265197
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.94175
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.335
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UMC-11	GDSC Cell Line Gene Expression Profiles	-1.0	-2.98012
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K74056311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06423
IC-80-CT90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34635
A-Vietnam-1203-2004(H5N1)_2day-wtC57BL-6J_None_GSE40792	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.57249
RCC1	Pathway Commons Protein-Protein Interactions	1.0	null
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31001397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18952
AF-80-GK24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203654
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162051
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05408
SUB1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75637705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22176
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878341
BRD-K06002536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57727
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215293
SW-403 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.6518
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
Chaperone complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K43789905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53959
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404344
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL-60	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.39296
GTEX-R45C-1226-SM-48FEE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930349
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NK-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
WAY 316606	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
Basolateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31731
GTEX-VJWN-0626-SM-3NMAN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901928
BRD-K97721960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15443
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
FEN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K34839838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34645
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.67331
OVTOKO	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.58786
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86951121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30443
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91375
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51505
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09152
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.975746
VMRCLCD	CCLE Cell Line Gene Expression Profiles	-1.0	-3.07442
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544756
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60850201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33845
BRD-K19755525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6792
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
TFAP2C_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05311
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
BRD-A34492468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74262
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10453
PMC10709143-41556_2023_1271_MOESM7_ESM.xls-PAX7_Re-injury-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
CKAP5	Pathway Commons Protein-Protein Interactions	1.0	null
LK2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72795
NANOG	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72351789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56743
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10073
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67195
Lung squamous cell carcinoma_LUSC_TCGA-39-5027-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.78835
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02575
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905936
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327333
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.957118
BB-83-OX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.535622
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
a549	HPA Cell Line Gene Expression Profiles	-1.0	-0.917719
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
GTEX-WFON-1826-SM-3GILG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20864
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nmyc_OE_GDS2406_14_mouse_LUNG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950039
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23988
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.722
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2194
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.55298
BRD-K65987370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68897
regulation of mitotic cell cycle phase transition	GO Biological Process Annotations 2015	1.0	null
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29732
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412366
central medullary reticular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.826404
regulation of proteolysis involved in cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K76482408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94815
regulation of cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-IS-A3K8-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.63603
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940223
BRD-K87909389_S1230_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.077
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936973
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
COV644	CCLE Cell Line Gene Expression Profiles	1.0	1.35988
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pridinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03296
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845037
Lupus Erythematosus, Systemic	HuGE Navigator Gene-Phenotype Associations	1.0	null
SNX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25046
BRD-A67254212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15608
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90448
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37875
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.4221
SARS-BatSRBD_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.27696
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09546
3649_HBE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508306
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	2.72975
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
MAPK1IP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56617
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.609926
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02238
BRD-A64957606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01132
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-34-DT48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335533
chr18_12694986_A_G_b38	GTEx eQTL 2025	1.0	1.20764
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.5068
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A72Z-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33261
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4076-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.092
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.271604
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9297
paclitaxel_homo sapiens_gpl570_gse11550	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177981
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
Chilblain lupus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.625
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27333
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42468
GSE225900_1_v_0_hsdl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0341
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
natural killer cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.08434
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.602756
USP39	Pathway Commons Protein-Protein Interactions	1.0	null
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.286
RAB35	Pathway Commons Protein-Protein Interactions	1.0	null
MF-81-RJ18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286816
MYC-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55868
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870589
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
AP1S2	ChEA Transcription Factor Targets	1.0	null
ARF6	Pathway Commons Protein-Protein Interactions	1.0	null
TRPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00760353
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295098
CREB1	ENCODE Transcription Factor Targets	1.0	null
BRD-K66248685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62692
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.827359
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51658
BRD-K55135464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46051
BRD-A13122391_16-HYDROXYTRIPTOLIDE_MCF7_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
albendazole-oxide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31448
SKMEL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3506
DLD	Pathway Commons Protein-Protein Interactions	1.0	null
K-562	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.03057
JARID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21679
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.923746
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330495
Proteasome activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.757
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920537
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.82851
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Proteasome-associated autoinflammatory syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A98888138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17571
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4153-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
18535662-TableS2d	GeneSigDB Published Gene Signatures	1.0	null
BMP2K	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.71206
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vasculitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
CRCGN010_HEPG2_24H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99025
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965371
BRD-A75954196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03509
BRD-K40222892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6024
BRD-K95678449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24214
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3507
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925204
BRD-K53639581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22485
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24087
MAFK	ENCODE Transcription Factor Targets	1.0	null
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.02391
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-37-JM16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216622
SERPINB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662904
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2442
LASP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL27A	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30458
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.53151
MDAMB157	CCLE Cell Line Gene Expression Profiles	1.0	1.86944
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66747
FERMT3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77743611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36304
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29148
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A20256229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26514
negative regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5225
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.05178
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41211
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
MRPS28	Pathway Commons Protein-Protein Interactions	1.0	null
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of chromosome organization	GO Biological Process Annotations 2015	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE5370	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.10856
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45744
Temporal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2806
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05668
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25714
BRD-A31946439_NCGC00241077-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05979026_NCGC00241726-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHOM2B	CCLE Cell Line Gene Expression Profiles	1.0	1.56563
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39429
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81572
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00573
EPS15	Pathway Commons Protein-Protein Interactions	1.0	null
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_299_KD_TPRX1/TPRX2/TPRXL_SRP361145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.62744
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6074
temporal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.94371
BRD-K49371609_528116.cdx_HA1E_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OD-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8844
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM21	Hub Proteins Protein-Protein Interactions	1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.05605
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91419
BRD-K82609503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49671
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lateropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15105
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056675
posteroventral part of alar p3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15105
Learning Disorders	CTD Gene-Disease Associations	1.0	1.20719
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936953
SMAP2	Pathway Commons Protein-Protein Interactions	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.99723
Paraventricular hypothalamic nucleus, descending division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20795
TWIST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41274
regulation of apoptotic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11495
GTEX-XLM4-0226-SM-4AT4N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04602
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17642
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852845
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.929871
SARS-dORF6_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.96939
TARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73577714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60476
KYSE-520	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12995
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGSF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12778
GTEX-QDT8-0226-SM-32PL4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06256
BRD-A40504327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22896
XD-44-FJ34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215548
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2783
Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.92792
BRD-K14763154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82579
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SU-DHL-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.20765
MCF7_Toremifene Citrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00969462
GTEX-R55G-2126-SM-2TC67	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912104
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70W-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral hypothalamic area, tuberal part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.855164
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.991
Dorsal part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26756
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2941
CRCGN011_HEPG2_24H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58965
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
EZH2	ENCODE Transcription Factor Targets	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445581
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77695
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222469
BRD-K81884775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02748
BRD-K12312755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18811
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99404
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.35071
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxycycline_mus musculus_gpl2872_gse33875	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypopharyngeal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
RAD21_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50575036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15986
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.65793
MCF7_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012153
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71099
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.495
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.889232
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66X-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47217000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25627
BRD-K04275703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16866
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Autoimmune interstitial lung, joint, and kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.714
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67352
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46037
UVSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16804
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54015
reticular formation of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11046
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995633
BRD-K93726930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.123
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.119
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.14608
BRD-K83115435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06683
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336769
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221128
retrosplenial cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67783
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE1551	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.39786
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ajmaline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16639
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92365
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RO-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hematopoietic stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDIA6	Pathway Commons Protein-Protein Interactions	1.0	null
HC-18-NB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414708
BB-83-OX58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394232
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52499
BRD-K02473319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51113
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03452
caudal putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36346
VCL	Pathway Commons Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05081
RAD21_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48255
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27013
SEPT9	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41A-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92446632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54682
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.861062
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4666-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
KANK2	Pathway Commons Protein-Protein Interactions	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66548
RAD21	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A77W-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-87-EI21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317354
BRD-A52893269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99107
BRD-K24499562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41689
SAR1A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95871937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31288
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.3899
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54106
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
ANAPC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57606
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLNS1A	Pathway Commons Protein-Protein Interactions	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401623
CDC27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.005
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLT-4 cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
peduncular paraventricular area of PHyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00035
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.76039
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A89237309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26081
DUS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06852
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.991
OC-21-IP52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264264
BRD-K19502817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53219
Plasma cell leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222327
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388987
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIMA	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70824
DBTRG-05MG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.77793
BRD-K54100199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65463
MCF7_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101529
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492444
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Basomedial amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1334
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11264
U937	CCLE Cell Line Gene Expression Profiles	1.0	1.40318
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.09848
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.1516
CFPAC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89757
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14352
Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14626_KO_OGT_SRP146064	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.57115
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.953
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.14608
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42446
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881429
hsa-miR-3163	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Presubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62441
GTEX-TKQ1-0226-SM-33HB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17965
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25734
GTEX-QDT8-1026-SM-43V6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836235
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16388
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K12517207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82904
PPARG-20176806-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994084
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222336
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
8759_TBX5_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58007
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872546
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.23323
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47673408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15711
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.497918
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.060499
A549_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154822
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BD-48-ZT65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336337
regulation of protein catabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.662
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30389
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03959
RAD21_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.36275
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14383477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00272
SH3GLB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0648
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.09366
RPS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10622
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91276
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0426-SM-32QPI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14097
BRD-K65602491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1119
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05220907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4671
inferior frontal gyrus, opercular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.929216
proteosome-associated autoinflammatory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.917
regulation of catabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10744
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.30323
HCC-56	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126562
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.8017
SHP-77	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.48078
asthma	GWASdb SNP-Disease Associations	1.0	0.51563
lymphnode_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.95483
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39415
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16738
Hyperplasia	CTD Gene-Disease Associations	1.0	1.51305
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	227.103
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Familial Mediterranean fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75801
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96723
BRD-K75074041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44091
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	221.999
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21306
Edema	CTD Gene-Disease Associations	1.0	1.18652
RSU1	Pathway Commons Protein-Protein Interactions	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.977039
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59301
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339126
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2316
BRD-K62202988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39353
BRD-K73608149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60303
BRD-K26704304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.94394
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-487a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Psmb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
REST	ENCODE Transcription Factor Targets	1.0	null
RPS15	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98793503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18804
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.02214
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42117
MHHCALL2	CCLE Cell Line Gene Expression Profiles	1.0	1.40692
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991931
BA-90-AA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260944
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.888853
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.17123
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLIC5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SIU7-0226-SM-4BRX2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854468
YD8	CCLE Cell Line Gene CNV Profiles	1.0	1.36695
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32636001_MLS-0437446.0001_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Basomedial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1334
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-X6-A8C3-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04934
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61537
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53178
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72705
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54242
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ST13	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59402582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36282
r5 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17673
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93561942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25777
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.75358
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83566
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52259
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5973-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7725-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7285791__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GA-28-SS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294852
SIPA1	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K052	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.09182
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KE-37	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.86797
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.681471
S0-EE-Y79N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366637
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7121
Field CA2, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01926
zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.435501
BRD-K45136330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14691
regulation of proteasomal ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
SE-81-RI20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292135
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PSMG1	Pathway Commons Protein-Protein Interactions	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.13234
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41814083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31989
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.94981
Outer dense fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.947
Intercalated amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45742
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51107
regulation of chromosome segregation	GO Biological Process Annotations 2015	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2214
ALDOA	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAC1-PAC2 complex	CORUM Protein Complexes	1.0	null
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09315
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.955163
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.054811
IE-80-DC24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316508
DUSP16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497219
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.538532
KYSE-450	GDSC Cell Line Gene Expression Profiles	1.0	1.72548
BT-549 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
intermediate stratum of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11046
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166162
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836043
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD15	CCLE Cell Line Gene Expression Profiles	1.0	2.26398
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07336866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1491
Oligospermia	CTD Gene-Disease Associations	1.0	1.06152
BRD-K13265046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69075
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14598
MDAMB468	CCLE Cell Line Gene CNV Profiles	1.0	1.59507
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08649
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88658
SB-09-JU93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275159
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39484304_triptolide_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K24977393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14637
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54766
GSE218060_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838475
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22072
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.97164
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83363
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.548719
mantle zone of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48372
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69597
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.07414
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.845096
MCM2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73459389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05688
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833728
Brain Lower Grade Glioma_LGG_TCGA-DB-5277-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
GTEX-X4LF-1726-SM-3NMBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877615
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83566
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VPS35	Pathway Commons Protein-Protein Interactions	1.0	null
retropontine reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14813
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58363
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26666
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49528360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4789
SPTBN1	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42C-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51017127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01721
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24934
NCIH810	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14075
BRD-K90103010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23074
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05164
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.272
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of mitotic cell cycle	GO Biological Process Annotations 2015	1.0	null
MCF7_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184148
CRCGN015_MCF10A_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1846
regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27193
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01546
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FN1	Pathway Commons Protein-Protein Interactions	1.0	null
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37014
BRD-K09203354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80122
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367249
MCF7_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173944
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41527
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04547
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of protein catabolic process	GO Biological Process Annotations 2015	1.0	null
CBX3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76558091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03309
GTEX-S3XE-1626-SM-3K2AJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844146
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61560971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11431
Posterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92365
LGALS1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26745
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053094
BRD-K45589340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1554
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.43171
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414797
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.179
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62698
GLRX3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:M05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14586
BRD-K09160804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30824
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89764
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24335
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
myc_17159920_cancer_cell_lines_lof_human_gpl570_gds2526	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.136119
u138mg	HPA Cell Line Gene Expression Profiles	1.0	0.950073
core part of DTg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04752
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12238
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.6868
PMC4172779-13048_2014_87_MOESM1_ESM.pdf-100-SLC2A4RG_SLC2A4RG	Rummagene Transcription Factor Associations 2026	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
AIMP2	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405507
DCP1A-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CAPZA1	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926867
ParietalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.18077
BRD-K17122222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88215
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249514
RAB5C	Pathway Commons Protein-Protein Interactions	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421057
RPL29	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
Anaplasmosis_Leukemic Cell_GSE2600	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.90518
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.910464
BRD-K19183365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43747
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41249
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30768
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.30189
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12931
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01721
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
FB-29-KC76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236536
GSE199899_1_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BAG6	Pathway Commons Protein-Protein Interactions	1.0	null
CCT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39032
negative regulation of metaphase/anaphase transition of cell cycle	GO Biological Process Annotations 2015	1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	214.628
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05516
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	1.0	1.32078
MCF7_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115772
BRD-K16403365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65066
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VAPA	Pathway Commons Protein-Protein Interactions	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4619
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SLC35F6	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354662
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Retinal vasculopathy with cerebral leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52053
BRD-K10221669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54313
hematologic cancer	GWASdb SNP-Disease Associations	1.0	0.165532
Proteasome assembly chaperone 2	InterPro Predicted Protein Domain Annotations	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05693
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
negative regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
AC-50-FR41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220137
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.847812
Perturb_9113_OE_FOXO1A3_SRP188991	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.42
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E6-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05826
BRD-K56424158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95631
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06035
KYSE-510	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.50237
MRPS6	Pathway Commons Protein-Protein Interactions	1.0	null
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
RAD51B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529173
ARID3A	ENCODE Transcription Factor Targets	1.0	null
DDX18	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95147720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12812
Lipodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.178
lymphoblastoid cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.854729
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08735
FASTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06803
regulation of cell cycle process	GO Biological Process Annotations 2015	1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927649
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH810	CCLE Cell Line Gene Expression Profiles	-1.0	-2.31656
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896117
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14446
E2F1	ChEA Transcription Factor Targets	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920537
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14847
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20981
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GRIPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0367
Perturb_2728_KD_NEK2_SRP231163	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.7092
FUNDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71533
KELLY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63447
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
EFM19	CCLE Cell Line Gene CNV Profiles	-1.0	-2.04143
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7285791__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.77124
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.42217
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04787
UHRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53169
ARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74575
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34612
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4648
periventricular stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20101
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.95384
mantle zone of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03064
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548ab	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
ventromedial hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26863
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451973
Posterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74285
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.88081
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61604
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4415
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RH-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0478
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K07196884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12716
bronchial disease	GWASdb SNP-Disease Associations	1.0	0.51563
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77764
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7572
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14603
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.34061
BRD-K26694226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61491
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.233
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20327
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.842611
palmatine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45201
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6435
Inflammation	CTD Gene-Disease Associations	1.0	1.1294
CLIC2	Pathway Commons Protein-Protein Interactions	1.0	null
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA3_01_163	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	9.19634
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.3036
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42650945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94078
DC-43-KF54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206984
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0833
PAICS	Pathway Commons Protein-Protein Interactions	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.578297
Acrosomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.365
Polyarteritis nodosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
Posterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91276
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SECISBP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30015
MYBPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616991
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	208.136
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23454
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.37567
BRD-K06772291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.82942
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Solitary median maxillary central incisor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.84963
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118411
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07853
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4T-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K22093970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9635
SYK_druginhibition_290_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.24201
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53199
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09443
Entorhinal area, medial part, dorsal zone, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32325
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A73909368_DACTINOMYCIN_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4566-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colorectal cancer cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.58612
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.70432
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
upper dorsal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20795
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.00916
Proteasome assembly and regulation	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Proteasome core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.396
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
P12-ICHIKAWA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PHOX2B-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
IF-87-AU84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229041
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.85025
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.847523
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Idiosyncratic drug effect_Hepatic Tissue_GSE2825	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.90296
FOXO3	ChEA Transcription Factor Targets	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92365
negative regulation of proteasomal protein catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926557
NHP2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOLLIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02365
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.38163
GSE144484_2_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21259
3331_GDI2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538625
KY821	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.54359
SEC24C	Pathway Commons Protein-Protein Interactions	1.0	null
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
Pulmonary alveolar proteinosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.90231
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989122
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976135
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72651085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5082
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.6475
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951653
BRD-K74039237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11016
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.9708
GM2493	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.0025
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ANP32B	Pathway Commons Protein-Protein Interactions	1.0	null
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.647
SW1573	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.12628
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.636177
NCI-H250	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45381
CRCGN015_MCF10A.TP53.M_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3667
u26684	HPA Cell Line Gene Expression Profiles	1.0	0.951679
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.542076
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74158
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33523
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03662
K562_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174535
BRD-K65933652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24955
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62441
OE19	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81005
NCIH522	CCLE Cell Line Gene CNV Profiles	1.0	1.44395
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.966414
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	1.68808
BRD-K14262397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60166
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622283
GTEX-PSDG-0326-SM-48TCP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976097
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50774
BRD-A13122391_16-HYDROXYTRIPTOLIDE_A375_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92365
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01899298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77498
BRD-K62007935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26768
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07866
inner SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52182
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31731
BRD-K31834149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92129
Lung adenocarcinoma_LUAD_TCGA-55-8089-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14817
ARPC3	Pathway Commons Protein-Protein Interactions	1.0	null
BAG2	Pathway Commons Protein-Protein Interactions	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
proteasome-associated autoinflammatory syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.553
BE-66-UB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265475
YY1	ENCODE Transcription Factor Targets	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SB-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.002
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.745565
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UF-14-LK87_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253137
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.21287
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03070790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05908
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.2124
STMN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00478171
GTEX-OOBJ-0226-SM-2YUMM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848959
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01489
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.26676
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.511999
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38235
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21189
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-PZ-A5RE-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79833963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73732
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41301
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5319
BRD-K91671568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00052
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE239436,GSE239441_0_v_1_keap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SF3A3	Pathway Commons Protein-Protein Interactions	1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40854
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCC1500	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.58734
inner SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.91207
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06439119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05405
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172044
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A67788537_Salermide_SNGM_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Erythema nodosum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7916
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50072
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053131
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-7769-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9234
Perturb_10078_KD_ZC3H8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.71519
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.11976
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.885699
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47108
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00896
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.457
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13390322_HY-50940_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IFI35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22964
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284936
GTEX-TSE9-1226-SM-4DXTM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15389
BRD-A13983189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07863
AF-16-IB77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200976
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.346
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927649
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.85177
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.917
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50117
EIF5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chronic obstructive pulmonary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.550911
GSE153907,GSE153908_0_v_1_azathioprine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833728
SET	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K24047785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06962
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q9-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERLIN2	Pathway Commons Protein-Protein Interactions	1.0	null
GE-58-RW27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22742
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.893756
GATA1_G1E-ER4_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMA2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41189799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09251
NSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16846
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05795
BRD-K04695993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29452
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K29130550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41661
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral medullary reticular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.832123
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16423883-Table2	GeneSigDB Published Gene Signatures	1.0	null
COMT	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1428	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83942
BRD-K67566344_KU-0063794_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRIP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28399
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62299
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE164884_2_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRKCB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24826
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7211-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K81082552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36601
EC-42-DO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222064
GTEX-QDVN-2226-SM-2S1PM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884867
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30002
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8069
VDR	ChEA Transcription Factor Targets	1.0	null
UA-39-TN76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207187
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.22077
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201582
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LTBR_INHIBITION - 2 Days_GDS2005_729_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.935976
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33872
BRD-K31616862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87492
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2237
CTCF	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TPR	Pathway Commons Protein-Protein Interactions	1.0	null
OE19	CCLE Cell Line Gene Expression Profiles	1.0	2.36135
ALDH1B1	Pathway Commons Protein-Protein Interactions	1.0	null
negative regulation of cell cycle process	GO Biological Process Annotations 2015	1.0	null
designated	GeneRIF Biological Term Annotations	1.0	null
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.071173
Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145455
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79771
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
paclitaxel_homo sapiens_gpl570_gse19136	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K40112492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08884
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
BRD-K40419401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33697
vincristine_homo sapiens_gpl570_gse7556	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.071
VMRCLCD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46383
SNU308	CCLE Cell Line Gene CNV Profiles	1.0	2.26448
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7454
Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Familial cold autoinflammatory syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
m1Lim part of the midbrain reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32325
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12724_KO_BRG1/BRM_SRP255094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63781
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of cell cycle phase transition	GO Biological Process Annotations 2015	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.805
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CELF2	Pathway Commons Protein-Protein Interactions	1.0	null
AA-46-GL76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292389
GTPBP4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOS_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of chromosome organization	GO Biological Process Annotations 2015	1.0	null
PDCD10	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.2436
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Retrosplenial area, dorsal part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19675
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35224
STOM	Pathway Commons Protein-Protein Interactions	1.0	null
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290747
Acute Myeloid Leukemia_LAML_TCGA-AB-2834-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143168
C14orf166	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TC-YIK	GDSC Cell Line Gene Expression Profiles	1.0	2.02996
BRD-K79090631_CGP-60474_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Familial cold autoinflammatory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.949437
AARS	Pathway Commons Protein-Protein Interactions	1.0	null
Entorhinal area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67783
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11754
Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48372
mantle zone of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19424
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943685
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.28337
GATA1_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI4KA	Pathway Commons Protein-Protein Interactions	1.0	null
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.647
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80290360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48499
QE-18-WG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260567
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2297
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00937
MYB	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-LC-A66R-01A-41R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SJXC-0126-SM-2XCFF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16688
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87702
BRD-K89260735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29084
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.53277
hsa-miR-1272	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Perturb_8339_OE_MSI1_SRP219036	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.11133
Hepatic venoocclusive disease with immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270205
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25575
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.4284
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45441
CFPAC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93257
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66733
BRD-A62182663_YK 4-279_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
16872506-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
SNRPB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KARPAS-45	GDSC Cell Line Gene Expression Profiles	1.0	1.52249
BZW2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07838
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.050702
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
maturation	GeneRIF Biological Term Annotations	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.11164
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
L755507	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13897
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26366
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.11475
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08025
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A685-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PUF60	Pathway Commons Protein-Protein Interactions	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.0497
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UD-09-TN01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236987
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
negative regulation of mitotic sister chromatid segregation	GO Biological Process Annotations 2015	1.0	null
PPID	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86271
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01935
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936323
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251242
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53605
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051726
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245167
GEMIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05384
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.87023
AKR1C1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41844
BRD-K29242326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55341
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH69	CCLE Cell Line Gene CNV Profiles	1.0	1.55759
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.029
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238317
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.09072
PICALM	Pathway Commons Protein-Protein Interactions	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04457
BRD-K77638937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60315
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963358
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
root nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.519647
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29223
BRD-K73692505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23824
BRD-K65005022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1502
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.21695
RA-49-ZB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289096
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EM-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.16109
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1933
KAT2A	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16156
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K01705159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61827
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17823238-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Perturb_7385_KO|KD_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
IPC-298	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pontine reticular nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1166
BRD-A25869984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15418
lateral habenular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849076
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.525839
rostral secondary prosencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00744
chaperone1	GeneRIF Biological Term Annotations	1.0	null
E2F1	Pathway Commons Protein-Protein Interactions	1.0	null
SNAP23	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87080934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21275
ETS1	ENCODE Transcription Factor Targets	1.0	null
BRD-K87909389_HY-10005_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84158675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19413
Spermatoproteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.383
POLR2A	ENCODE Transcription Factor Targets	1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.512967
BRD-K73479560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17059
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PSMA5	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A31946439_NCGC00241077-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60899
BRD-K12909905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36416
BRD-K69569958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33975
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4145
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.34745
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX2_NULL MUTATION_GDS2184_719_mouse_Embryonal bone (MG-U74A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96127
STING-associated vasculopathy with onset in infancy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.219
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NOP58	Pathway Commons Protein-Protein Interactions	1.0	null
PAFAH1B2	Pathway Commons Protein-Protein Interactions	1.0	null
DB-41-IH69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387244
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.79227
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0107359
BRD-K41714444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25373
SPPL2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0080701
Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF3B1	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.963508
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2404
CINCA Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-0944-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NDRG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56375
Alopecia areata	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.622185
WDR36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30986
BRD-K32839286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05052
Perturb_7537_KD_RREB1_SRP265233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.42793
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478262
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865933
Weight Loss	CTD Gene-Disease Associations	1.0	1.19014
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06507
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SEPT2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2-16153702-HESC-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
NECAP2	Pathway Commons Protein-Protein Interactions	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09576
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues	GeneRIF Biological Term Annotations	1.0	null
BRD-K06243138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15968
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitotic spindle checkpoint	GO Biological Process Annotations 2015	1.0	null
BRD-K77354700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49039
IE-38-FB31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228823
shell of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60774
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74721
Nuclear pore outer ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.94
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.632533
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58649
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inflammatory bowel disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.991
TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-1826-SM-3K2AL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866033
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9087
BRD-K27294633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77097
GT3TKB	GDSC Cell Line Gene Expression Profiles	1.0	2.21026
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98854
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7236
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	136.239
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48421
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977128
BRD-K17040651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63711
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893279
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.870835
BRD-K00542622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48279
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	172.424
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11982
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75058
BRD-K23835343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00886
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09655230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32794
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230161
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46115
BRD-K36099605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34017
negative regulation of cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-LK-A4NY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.917432
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45424
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01435
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08144
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01203
PMC12885947-44386_2025_32_MOESM1_ESM.pdf-20-ZNF442_ZNF442	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07693
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.3466
GSE133927_1_v_3_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 2 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26756
X-linked reticulate pigmentary disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.794
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37165
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275767
MCF7_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123986
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CA-48-SW47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236592
Bone inflammation disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08408
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07863
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126838
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.632168
EST1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K99277076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39399
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07428
JF-84-QZ64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205339
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07383
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.416
CMK	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46227
heterodimer	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06446
Prostate adenocarcinoma_PRAD_TCGA-HC-7821-01A-12R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K97395479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22046
BRD-A52530684_DOXORUBICIN_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MKN74	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81986
BRD-K56563758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18409
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.921
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24486
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22415
PDK1_knockout_265_GSE42187	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.7417
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106972
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902903
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839705
Lateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19748
TECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49788
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.05557
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13763
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6L9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2-22936984-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49733350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30767
BRD-K13196166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18669
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28913
layer 2 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74285
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32120119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23103
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923438
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.17659
MRTO4	Pathway Commons Protein-Protein Interactions	1.0	null
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.1991
BRD-K92241728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25801
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	2.79019
ELF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38743
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57163
MXI1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.47585
NAA15	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02837259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00557
PRDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32539
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12959
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29939
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827725
PSMD13	Pathway Commons Protein-Protein Interactions	1.0	null
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
zinc acetate_homo sapiens_gpl570_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAD21_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.162811
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.27471
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435431
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02516
BRD-K15977595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04105
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02607
GSE205070_1_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.542139
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.5
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CLEC11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08294
proteosome-associated autoinflammatory syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.533
BRD-K42732309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06154
BRD-K82362034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59041
MCF7_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137304
PARD6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64455
GTEX-T8EM-1126-SM-3DB7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829141
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADAM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00282
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23251
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.38555
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.870777
EC-01-PH79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254015
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27155
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SND1	Pathway Commons Protein-Protein Interactions	1.0	null
negative regulation of chromosome segregation	GO Biological Process Annotations 2015	1.0	null
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.828742
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.88028
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
BRD-K76353834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07173
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40865
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.07
STN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17036
MAPRE1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57621
eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.655248
BRD-K72379955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33162
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
GAR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90060707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35284
GSE190681_1_v_0_rtcb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158879
RAD21_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.82657
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.88084
STIP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26293
SARS-BatSRBD_0Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.0295
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24097
GTEX-T2IS-0226-SM-32QPH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899401
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3452
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.684667
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LA-44-KW22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326485
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64100337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03729
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1114
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.04352
MPP1	Pathway Commons Protein-Protein Interactions	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03008
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1134
Enterovirus 71_8Hour_None_GSE15323	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.0545
Fatty Liver	CTD Gene-Disease Associations	1.0	1.48402
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6984
BRD-K43911180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18743
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.40444
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05636
obstructive lung disease	GWASdb SNP-Disease Associations	1.0	0.32795
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB10	GDSC Cell Line Gene Expression Profiles	-1.0	-2.63623
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.857015
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4099-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09919985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32857
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.346
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.87121
DA-10-HD17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.49512
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
basolateral amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67783
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.9059
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7465-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
homatropine-methylbromide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24905
9454_TXNIP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.80405
ARHGEF1	Pathway Commons Protein-Protein Interactions	1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.981801
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7595-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856755
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
WD-62-UB45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451822
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40708
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-QV31-1326-SM-2S1QE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967021
NARS	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02317
abnormality of lymphocytes	GWASdb SNP-Phenotype Associations	1.0	0.439838
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13663
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SN8G-0226-SM-4DM6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5722
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991615
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0149
AA-56-JY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202808
KIF20A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35057
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Temporal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17763
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902761
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.50871
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Metabolism of proteins	Reactome Pathways 2024	1.0	null
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OE19	GDSC Cell Line Gene Expression Profiles	1.0	2.40875
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21864149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41631
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73466
BRD-A73909368_DACTINOMYCIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39121
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356317
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64342
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900657
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906481
BC-26-LE04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241389
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06463
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149644
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4949
6884_PSMG2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.836497
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.36168
BRD-K70289438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06054
prethalamic (p3) zona limitans domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03487
intermediate stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22589
BEN	CCLE Cell Line Gene Expression Profiles	-1.0	-3.11605
CRCGN016_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02005
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530001
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07971
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2L3	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
DG-75	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.02161
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.531986
Gill raker	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.887
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11062
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.429
BRCA1	ENCODE Transcription Factor Targets	1.0	null
BB-77-QQ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242453
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
20937356-TableS2	GeneSigDB Published Gene Signatures	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.1364
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874928
EB-67-WB79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333684
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310527
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40022
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of mitotic sister chromatid separation	GO Biological Process Annotations 2015	1.0	null
MCM6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9139
DA-40-HO94_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274577
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34724
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
CAL-12T	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46003
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.69077
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839583
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Epididymal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
TGBC1TKB	GDSC Cell Line Gene Expression Profiles	1.0	1.55209
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88222
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, medial part, dorsal zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16879
RPA1	Pathway Commons Protein-Protein Interactions	1.0	null
Sperm mitochondrial sheath	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
olfactorybulb	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.827098
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13785
EA-00-RN06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212135
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.51563
RAB1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13519
TestisLeydigCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.17073
BRD-A75144621_digoxin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
macrophage	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05126
BUB1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00402759
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14959
CRCGN010_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35568
Acute lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927649
CRCGN011_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30335
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.921561
STX1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515031
proteosome-associated autoinflammatory syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.73
regulation of mitotic metaphase/anaphase transition	GO Biological Process Annotations 2015	1.0	null
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376813
NUP205	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52389
CRCGN015_MCF10A.TP53.M_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1282
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SNU283	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40144
SLC25A39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75066
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.50329
superficial stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37387
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43828
BRD-K95218317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21343
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38652
BRD-K67661742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22042
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
c-MYC_KD_GDS2526_109_human_Hela cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71042
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPS2	Pathway Commons Protein-Protein Interactions	1.0	null
negative regulation of mitotic cell cycle phase transition	GO Biological Process Annotations 2015	1.0	null
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.34029
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242258
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.65021
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265188
MAFK_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GMPS	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Entorhinal area, medial part, dorsal zone, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31731
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92956
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
AC-91-ME22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229688
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92579151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78441
layer 1 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17763
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53807
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71009
SAP30	ENCODE Transcription Factor Targets	1.0	null
Outer acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.221
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23136
SNU-C5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
SRSF9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
a94p	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.054
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.15383
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.990892
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6965
BRD-K54224946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22652
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900579
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1435	CCLE Cell Line Gene Expression Profiles	-1.0	-1.99572
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056146
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K16695519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73053
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.842997
BRD-K51175229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35547
MYB_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K41604824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00111
BRD-K44027058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49444
Autoimmune disease of gastrointestinal tract	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.647
Squamous cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
BRD-K73695595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29774
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88559
EGR1	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.860977
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18089
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.81159
chr18_12664279_C_A_b38	GTEx eQTL 2025	1.0	1.24212
Retrohippocampal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23056
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12258
SOX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58214
PSMG3	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11113009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05814
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
NCIH1341	CCLE Cell Line Gene Expression Profiles	-1.0	-2.57598
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9002
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297459
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4309
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897978
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77564
Perturb_2752_KD_ADAM12_SRP077683	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.2454
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A38359809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3419
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38187
BRD-K53417444_OTSSP167_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12312
BRD-K68732617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04957
biological_process	GO Biological Process Annotations 2015	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882079
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.922637
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08377
TESPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576798
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61978712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14962
mantle zone of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06339
MM1-R cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of protein processing	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.35515
BRD-K20798215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21083
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.59317
BRD-K20984459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19145
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228678
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827102
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53963
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10716
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJHI-1626-SM-3DB9A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04779
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94225
ChIP_SOX17_20123909	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518175
MORCPR	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99699
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.05866
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
Autosomal dominant familial periodic fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
substantia nigra reticulata, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11108
BRD-K47926785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32066
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
negative regulation of apoptotic process	GO Biological Process Annotations 2015	1.0	null
BRD-K95251122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40937
KIF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59759
dactinomycin_mus musculus_gpl6246_gse21233	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.832844
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056702
parasubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41212
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Panniculitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.176
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35232
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.991
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1108
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309532
differentiated	GeneRIF Biological Term Annotations	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.28371
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07693
CAV3_KO_GDS3533_357_mouse_mammalian glands	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89935890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14531
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149075_8_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15848
kidney	HPA Tissue Protein Expression Profiles	1.0	0.864212
BRD-K47348275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14052
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10654
GTEX-WFJO-1926-SM-3GILA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01984
skeletal muscle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42426
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51526
CADOES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6377
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.991
CAPZB	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.845472
BRD-K53889798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33035
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8833
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPN1	Hub Proteins Protein-Protein Interactions	1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6907
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPE	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23648
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41498330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48501
Lung adenocarcinoma_LUAD_TCGA-95-7944-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
Systemic lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
outer CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.962959
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42465630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62412
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nb4	HPA Cell Line Gene Expression Profiles	1.0	2.48215
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.002
NELFE	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1378
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907805
DOHH-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.69887
cellular protein complex assembly	GO Biological Process Annotations 2015	1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ventral tegmental area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36501
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.843059
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7205
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13047
GATA1	ENCODE Transcription Factor Targets	1.0	null
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
Immunodeficiency 38	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292394
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5204
HC-18-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376081
BRD-K39962926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0511
regulation of organelle organization	GO Biological Process Annotations 2015	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CNN2	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A44S-01A-12R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
imatinib_homo sapiens_gpl571_gds3518	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	207.786
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49644
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.41018
BRD-K71817712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26801
CAL120	CCLE Cell Line Gene CNV Profiles	1.0	1.76481
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38967
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.963564
ATM_knockdown_18_GDS1852	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.90689
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.06106
ZB-16-BR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263172
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3145-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ZNF425	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16857
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14241686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66254
lateral periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37345
GTF2A1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23995
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.35915
negative regulation of cell division	GO Biological Process Annotations 2015	1.0	null
NUP155	Pathway Commons Protein-Protein Interactions	1.0	null
NCOA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00412364
FAM86B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10378
BRD-K03352392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42659
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56294
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25143
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.87314
SLC35E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28802
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF786	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41511
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
KIAA0368	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ITGA4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47650707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00418
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NAT10	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF408	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0697
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11011
Medial geniculate complex, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08194
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hl60	HPA Cell Line Gene Expression Profiles	1.0	1.46679
TAF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Decompression Sickness	DisGeNET Gene-Disease Associations	1.0	null
GSE157049,GSE157051_6_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.60987
hek293	HPA Cell Line Gene Expression Profiles	-1.0	-0.856535
IPO4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858165
BRD-K09137343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4498
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.883109
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08232
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292921
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5991
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58465
496100630_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03686
BRD-K31801624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48935
BRD-K93698227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16007
TE1	CCLE Cell Line Gene CNV Profiles	1.0	1.39349
QKI	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aseptic meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.41714
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360367
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00586
Subiculum, ventral part, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43336
GSE181589_2_v_0_spred1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BB-77-QQ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.768802
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.01025
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STX4	Pathway Commons Protein-Protein Interactions	1.0	null
leukemia	GWASdb SNP-Disease Associations	1.0	0.51563
Perturb_7913_KO_ZNF335_SRP367036	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.1391
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A84102390_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Celiac disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.536
HLE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17061
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27333
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245833
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01675
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24259
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857559
Acute Myeloid Leukemia_LAML_TCGA-AB-2833-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.891214
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.11693
lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060519
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885161
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.41859
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18765
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LD-14-PB06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284557
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11277
Prostate adenocarcinoma_PRAD_TCGA-HC-7736-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
layer 3 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74285
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01255
RPL28	Pathway Commons Protein-Protein Interactions	1.0	null
Zona pellucida receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
11032_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565279
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFV	Pathway Commons Protein-Protein Interactions	1.0	null
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.05045
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HSPG2	Pathway Commons Protein-Protein Interactions	1.0	null
layer 4 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62441
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84738
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39449566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07765
CEP76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53425
BRD-K66539236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54897
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11932
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3988
UBE2N	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.923662
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08334
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
medial geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08906
MAFK_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233638
hsa-miR-4699-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
peduncular nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05728
SF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S32W-1626-SM-4AD6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941412
BRD-K42644990_5122-2566_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRIK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505149
PMC7553775-elife-61287-supp1.xlsx-Muller_2014_DREAM_bound_genes-Genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72636697_QL-X-138_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BE-17-CS60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297432
pf382	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2653
urinarybladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.06283
BRD-U07805514_saracatinib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13851
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954291
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BA-69-TQ80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297731
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37336
RCOR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K05639803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14935
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5404
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20495487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77379
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857559
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.676
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1925
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMD11	Pathway Commons Protein-Protein Interactions	1.0	null
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382518
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
proteosome-associated autoinflammatory syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.313
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.119
CRCGN014_HEPG2_24H:B03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3991
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63972
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.12648
BRD-K56881825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44196
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.8523
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0376
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KRT2	Pathway Commons Protein-Protein Interactions	1.0	null
TE-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972573
HDQP1	CCLE Cell Line Gene Expression Profiles	1.0	2.78921
CTCF_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPF4	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28286
BRD-K85843964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46778
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.0827
BRD-K43896262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30789
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K16305571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17218
SKNBE2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34649
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14186
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38124
Perturb_2733_KD_BCKDK_SRP298085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.82129
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TU-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.663272
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92365
negative regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05837079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66397
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934797
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843687
NDUFA5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01311880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37336
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.8201
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13028
DA-58-LZ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373344
KM12	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55677
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.74698
Leukemia_promyelocytic-HL-60	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.11003
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67428
NCIH1963	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59083
BRD-K15008902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9282
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
proteasome assembly	GO Biological Process Annotations 2025	1.0	null
16651409-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00389
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15741
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3473
IL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17152
CTCF_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PrS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48372
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936973
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.79423
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31624501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63973
GD-51-SU60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23982
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20547
RAP2B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2611
SNU761	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91386
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.99033
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65423474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26003
CCNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7535
DIAPH1	Pathway Commons Protein-Protein Interactions	1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384228
GSE171401_1_v_0_adnp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11362964_5235244_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
nucleus	GO Cellular Component Annotations 2015	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pac1	GeneRIF Biological Term Annotations	1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.07573
Hypothalamic medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02033
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.977651
16715129-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.1081
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
TARDBP_02_116	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59714
GB-84-KP45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353657
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.592672
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830213
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.26015
Peroxisomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
CTCF_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99659
BRD-A35931254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96242
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03525
BRD-K73376409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4686
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HI-7171-01A-12R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936973
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41Q-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04680784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00127
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MORN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00788508
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53695
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.7765
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01687
mitotic cell cycle checkpoint	GO Biological Process Annotations 2015	1.0	null
BRD-K61522760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40689
Sarcoma_SARC_TCGA-DX-A6Z0-01A-13R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
ISGF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
Endopeptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.164
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
KLM1	CCLE Cell Line Gene Expression Profiles	1.0	1.62874
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57802
BRD-A68009927_Daunorubicin hydrochloride_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.899678
GSE215086_4_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
VPS26A	Pathway Commons Protein-Protein Interactions	1.0	null
VEXAS syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.83961
SNRPA	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
blast cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K58118393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37447
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	1.02613
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75386
HCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552714
Inner acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.267
RPRML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50076
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PELP1	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29255
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
HOP62	CCLE Cell Line Gene CNV Profiles	1.0	1.84165
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.60603
QARS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.99
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YAPC	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.7295
TP53	ChEA Transcription Factor Targets	1.0	null
BRD-K29850806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26689
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53624506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1938
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.621309
A101D	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42133
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75299
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90138084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01735
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19542
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288563
BRD-K57167256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3225
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.8888
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28586
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H810	GDSC Cell Line Gene Expression Profiles	-1.0	-2.32095
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51395
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.94448
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366788
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40767
HC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4968-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051115
PMC8047442-EMBJ-40-e105492-s003.xlsx-MR_plot_analysis-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220892
GTEX-P4PQ-0726-SM-3NMCR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858015
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
RFX5	ENCODE Transcription Factor Targets	1.0	null
ChIP_SOX2_19030024	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07957
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3456
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NB14	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57202
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.25279
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBM12	Pathway Commons Protein-Protein Interactions	1.0	null
Adenocarcinoma of lung_Lung Tissue_GSE11969	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.83552
BRD-K28950508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19564
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62935
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14121
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.568004
496100609_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09513
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467322
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67496
LIVF001-022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40447
FSCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07175
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79696
Actinic keratosis_Skin tissue_GSE2503	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-3.34198
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
immune system cancer	GWASdb SNP-Disease Associations	1.0	0.165532
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.883569
MCF7_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202707
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15802
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936989
BRD-A68631409_Evodiamine_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GATA1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993374
D341MED	CCLE Cell Line Gene Expression Profiles	1.0	1.6061
H3K36me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A02927672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08361
intermediate stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43872
TAF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ITGAV	Pathway Commons Protein-Protein Interactions	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
19286929-SuppTable2a	GeneSigDB Published Gene Signatures	1.0	null
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902903
GATA2	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41527
CTCF_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphopenia	GWASdb SNP-Disease Associations	1.0	0.51563
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.43905
NCIH747	CCLE Cell Line Gene CNV Profiles	-1.0	-2.77676
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6178
JB-89-SI60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200376
PRDX6	Pathway Commons Protein-Protein Interactions	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.621
CRCGN015_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81356
RBBP4	Pathway Commons Protein-Protein Interactions	1.0	null
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-54-JC89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414377
DOK	GDSC Cell Line Gene Expression Profiles	1.0	1.50682
NDUFS3	Pathway Commons Protein-Protein Interactions	1.0	null
LB-90-DC89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202262
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59254
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25437
QE-48-NG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209817
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05051
STK17A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515704
BRD-K73604422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23133
Perturb_8773_KO_ZNF410_SRP273250	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.77554
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03525
GTEX-OIZI-0226-SM-2XCEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32675
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48379
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76319
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF418	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89813
SNU869	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60401
BRD-A80502530_cinobufagin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050943
SEC23B	Pathway Commons Protein-Protein Interactions	1.0	null
MYL4	Pathway Commons Protein-Protein Interactions	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051631
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414119
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NC-06-IT89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22619
GTEX-SSA3-0226-SM-32QPN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42769
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94904
CRCGN015_MCF10A.TP53.M_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51265
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.284
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23988
BRD-K78297750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43912
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.058014
Pyoderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4897
NDUFA9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ubiquitin activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K77392050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36969
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.836237
POLR2C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828456
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.977673
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845662
BRD-K68608492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35353
Proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.193
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46545
Geniculate group, dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06339
BRD-K82126187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44531
GTEX-W5X1-2626-SM-4LMI8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978829
SCRIB	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6326
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37529
Subiculum, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35635
Neurosphere_Cultured_Cells_Cortex_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.43192
BRD-K91615044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31905
GTEX-TSE9-0326-SM-3DB82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24206
BRD-K25595086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02716
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498923
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11381
MYL12B	Pathway Commons Protein-Protein Interactions	1.0	null
MET_knockout_257_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.14521
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.4457
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACTN4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03383
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903452
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35918
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8304-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44894536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04583
TTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27374
Intergeniculate leaflet of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08906
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15930337-TableS4	GeneSigDB Published Gene Signatures	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-A14803952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06695
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAV3_KO_GDS3533_17_mouse_mammary glands	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
FB-32-TL51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302513
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27645251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42041
BRD-K69087429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0894
BRD-A95207036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55884
BRD-K79688948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42754
GNAI3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31731
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K52863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20023
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73775927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27994
S0-EE-XMXE_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213425
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-27-TF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201222
CE-15-YU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27002
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23248
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K14795621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04868
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07103
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
GSE151782_2_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32087
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
BRD-K63665694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11862
GSE203429_0_v_1_angptl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACTBL2	Pathway Commons Protein-Protein Interactions	1.0	null
CHD4	ENCODE Transcription Factor Targets	1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965735
BRD-K56942203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68741
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42897
KIDINS220	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A15086915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31312
BRD-K03147246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09292
SRI	Pathway Commons Protein-Protein Interactions	1.0	null
Nitrate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
MEIS1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perinuclear theca	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.326
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH146	CCLE Cell Line Gene Expression Profiles	1.0	1.36033
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24531
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015084
STAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621029
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11024
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41515
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPNE1	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4501
body of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957924
BRD-K79090631_CGP-60474_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EOMES	ChEA Transcription Factor Targets	1.0	null
GTEX-W5X1-0526-SM-3GILH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24435
COV644	CCLE Cell Line Gene CNV Profiles	1.0	1.72012
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.526702
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.1644
APOD_OE_GDS3913_489_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
negative regulation of organelle organization	GO Biological Process Annotations 2015	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15572
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61885
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43719900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16593
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.86499
THBS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35281
GTEX-WFG7-2426-SM-3GIL2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37443
ND-36-VC68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200808
COPG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01318
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328671
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skeletal muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58092
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286326
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59123
Lung adenocarcinoma_LUAD_TCGA-86-8585-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265557
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358668
GSE149359_3_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K10288935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49934
HE-84-SC79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229469
PTGES3	Pathway Commons Protein-Protein Interactions	1.0	null
Crohn's disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.991
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92525
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21177
KRT18	Pathway Commons Protein-Protein Interactions	1.0	null
Childhood type dermatomyositis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03127
regulation of cell division	GO Biological Process Annotations 2015	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41029
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44323
COX7A2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66071
G6PD	Pathway Commons Protein-Protein Interactions	1.0	null
JF-84-QZ64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286406
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35659
BRD-A93236127_DIGITOXIN_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151974
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050185
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K79090631_CGP-60474_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.873847
CFPAC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42348
Gastric	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.04892
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35818
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RN-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914684
BRD-K56525823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13767
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.921951
placenta	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.00994
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82478
BRD-A33119430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07252
Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.30155
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91034
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.933477
HB-24-GP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.818577
GTEX-RVPU-2326-SM-2TF6R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2755
Perturb_14199_KD_GATA6_ERP108557	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.84811
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15674
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.824502
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.961
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51779559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23876
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.88431
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206419
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.676
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_8_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.911474
BRD-K17171256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32266
Hypopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
ZNF263	ENCODE Transcription Factor Targets	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.659529
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.43984
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59226
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57114
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.969077
Lung adenocarcinoma_LUAD_TCGA-62-A46P-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165473
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25391
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDHB	Pathway Commons Protein-Protein Interactions	1.0	null
Autoimmune thyroiditis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.676
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Esophageal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14482
CASD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29688
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.685377
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24735
BRD-A54347351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01188
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
UA-39-TN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217234
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
TCF3/E2A-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRC_overexpression_276_GSE37428	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.73297
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.60219
Entorhinal area, medial part, dorsal zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74285
MYC_Activation - 4 hours_GDS2025_724_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
postcentral gyrus, left, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.944067
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.902315
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20492
CAND1	Pathway Commons Protein-Protein Interactions	1.0	null
Entorhinal area, medial part, dorsal zone, layer 6	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81701
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP63	ChEA Transcription Factor Targets	1.0	null
GSE152432_1_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHST15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3443
mantle zone of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43177
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.551
intermediate stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03428
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320448
BRD-K75745696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71921
CSNK2A1	Pathway Commons Protein-Protein Interactions	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16922
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.825387
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46382
TRIM28	ChEA Transcription Factor Targets	1.0	null
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12801_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.14144
BRD-K14719962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09596
BRD-K90325960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79248
TD-69-UA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226874
anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.89797
Lymphoblastoid cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
Leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20331
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
negative regulation of nuclear division	GO Biological Process Annotations 2015	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21519
chr18_12670957_C_T_b38	GTEx eQTL 2025	1.0	1.5503
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
negative regulation of programmed cell death	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98596
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2521
K562_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182928
EC-01-PH79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375083
BRD-K55965167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13961
SNU761	CCLE Cell Line Gene Expression Profiles	-1.0	-2.13203
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-510	GDSC Cell Line Gene Expression Profiles	-1.0	-1.566
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99415
intermediate stratum of m1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32325
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.475
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6117
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.830564
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV362	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38136
regulation of mitotic nuclear division	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20715
RPL10A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21584435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11535
PMC11947124-41419_2025_7562_MOESM1_ESM.docx-175-ENSG00000169016_E2F6	Rummagene Transcription Factor Associations 2026	1.0	null
HUH7	CCLE Cell Line Gene CNV Profiles	1.0	1.43193
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63102090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34704
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22049
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
ABCF1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	146.761
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133467
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59974
Fetal Brain Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.04204
BRD-K55852567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48312
CRCGN015_HEPG2_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83777
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
BRD-A46778020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49695
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cyclic hematopoiesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2794-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LCLC-97TM1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.9996
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10082046-41467_2023_37049_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_Genes_upregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07486
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07598
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.05361
GTEX-P4QT-0226-SM-3LK68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02902
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.843059
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39247583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11611
single-organism process	GO Biological Process Annotations 2015	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13539
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU601	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46887
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07863
HIST1H2BJ	Pathway Commons Protein-Protein Interactions	1.0	null
LSM12	Pathway Commons Protein-Protein Interactions	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.86104
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41337
RPLP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14756138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0675
HCV JFH-1_18Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58268
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.420424
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.346
BRD-K18149487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.93298
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.757889
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mammalian	GeneRIF Biological Term Annotations	1.0	null
TTC9C	Pathway Commons Protein-Protein Interactions	1.0	null
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48558
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09486
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8423
irf1_17409403_nih3t3_gof_mouse_gpl81_gds2752	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.348877
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39081
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14756
BRD-K74881104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41462
6884_PSMG2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.772413
negative regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9002
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918193
Axonemal central apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33174
CRCGN015_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1609
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.354
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
RC-K8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64619
PMC2866657-pone.0010547.s003.xls-ESE3_corr-Genes_correlated_anticorrelated_to_ESE3_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
RPL15	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16612
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.346
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49989
RERFLCAI	CCLE Cell Line Gene CNV Profiles	1.0	2.2063
TUBB6	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7313
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-11-RK51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21358
RNH1	Pathway Commons Protein-Protein Interactions	1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15684
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.915873
BRD-A89681034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12472
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118468
C16orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01454
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857559
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83318
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47724892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22732
BRD-K72467884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73934
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198013
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24698
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262233
leukopenia	GWASdb SNP-Disease Associations	1.0	0.32795
OC-21-IP52_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209798
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.86122
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6829
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.90811
IGF2R	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863766
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24648
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12907
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.843059
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21598
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11287
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26687
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-dORF6_24Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.04935
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Plasma cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
Uterine leiomyoma_Uterus - Myometrium (MMHCC)_GSE593	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.9152
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-61-QB73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372907
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70I-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254137
Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03308
BRD-K67390084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02554
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cutaneous lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04994
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autoimmune disease of musculoskeletal system	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
MCF7_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205321
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZL-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSNK2B	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8564-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37942
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13613
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611275
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34162
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of cell death	GO Biological Process Annotations 2015	1.0	null
negative regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13782363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.96378
U2OS	CCLE Cell Line Gene CNV Profiles	1.0	2.02494
RPL36	Pathway Commons Protein-Protein Interactions	1.0	null
Leukemia cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.824054
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10623
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13756
SMC3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08328
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09391
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14833
BRD-K79568363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25969
BRD-K31218318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36768
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10474
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
r9 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26045
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33154
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BEN	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.53841
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2969-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-LT-A5Z6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPM3	Pathway Commons Protein-Protein Interactions	1.0	null
DCP1A	ChEA Transcription Factor Targets	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TFRC	Pathway Commons Protein-Protein Interactions	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11932
BRD-K17850764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71445
EPB41	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACLY	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of sister chromatid segregation	GO Biological Process Annotations 2015	1.0	null
layer 4 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09819
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24331
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACACA	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578242
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860888
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.867008
Hypertrophy	CTD Gene-Disease Associations	1.0	1.67355
BRD-K48519079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04408
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4756-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548y	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.8546
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27133
regulation of mitotic sister chromatid separation	GO Biological Process Annotations 2015	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986111
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYBL2	ChEA Transcription Factor Targets	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43404
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977128
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.873912
monastrol-614	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25488
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27907
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1009
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75856
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJB1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
protein complex assembly	GO Biological Process Annotations 2015	1.0	null
Aphthous stomatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83312314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01127
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47Y-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936334
3869_HNRNPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.723314
JJ012	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39127
GR-ST	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.29668
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17676974-TableS1	GeneSigDB Published Gene Signatures	1.0	null
1544_CHAF1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.583132
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU466	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92573
PSMB1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6332-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BF-26-MB27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258762
BRD-K07589203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13344
K562_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149401
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A59985574_T542500_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.029614
GNA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19874
PSMA6	Pathway Commons Protein-Protein Interactions	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rheumatoid arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
Endocrine system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.255
Autoimmune disease of cardiovascular system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
IGF2BP3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838344
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.463541
H3K9me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48269
GART	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8839_KD_WDR5_SRP258987	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.37566
JUNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18057
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVCA420	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.42984
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897944
BRD-K84241565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15781
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
LOX-1_OE_GDS4262_434_human_HAECT - aortic endothelial cell line - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.035066
CTCF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01783
layer 3 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43336
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.891719
A549_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173639
WEE1_druginhibition_307_GSE38972	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.20676
FLOT2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23542
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.8233
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.955
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927649
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4901
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SKNMC_BONE	CCLE Cell Line Proteomics	1.0	17.0698
BRD-K75990394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60946
lung	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.6394
BRD-K54505405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4711
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37828
KPNSI9S	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8152
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.89863
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435617
HAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18029
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.048
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRPE	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.962028
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10986
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
18535662-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
EB-67-WB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302842
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88544
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.05164
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74217
ESYT1	Pathway Commons Protein-Protein Interactions	1.0	null
terminal hypothalamus (rostral hypothalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25377
CRCGN016_MCF10A.TP53.M_24H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08285
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4853
DCP1A-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
Perturb_5551_KO_FBXO11_SRP149805	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.65328
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6869-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451716
PE-68-QD35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2352
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.1697
MF-17-BD63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202207
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35206
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.744139
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86039224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40773
ASXL1-24218140-BMDM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15633
BRD-K11752384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84662
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1	JASPAR Predicted Transcription Factor Targets	1.0	null
ACTR3	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
BRD-K51697562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11813
CRCGN015_MCF10A_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85016
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.2249
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.873136
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994084
negative regulation of mitotic nuclear division	GO Biological Process Annotations 2015	1.0	null
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7923
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97146
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479774
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.940584
GATA1_G1E-ER4_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_8_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12907
hsa-miR-548j	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEIS1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
U-2-OS	GDSC Cell Line Gene Expression Profiles	1.0	2.02421
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06446
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07159
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26756
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90686617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79112
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DC-02-OP01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402003
Perinuclear region of cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04968
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95656
BRCA1	JASPAR Predicted Transcription Factor Targets	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.52827
heart	GTEx Tissue Gene Expression Profiles	-1.0	-1.04193
PMC12289921-41467_2025_62099_MOESM5_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400489
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.18534
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
lupus erythematosus, systemic; systemic lupus erythematosus	GAD Gene-Disease Associations	1.0	null
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59315
BRD-K70200818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06553
BRD-K60759770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05684
ITGB1	Pathway Commons Protein-Protein Interactions	1.0	null
FLOT1	Pathway Commons Protein-Protein Interactions	1.0	null
AD-28-GJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205702
BRD-K20501114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07973
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165296
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20804
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.2816
Acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
Perturb_12337_KD_TFEB_SRP226507	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.68715
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157225
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10679
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.1908
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16217
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.072
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5752
HIST1H1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K50961262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14249
MDN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31614544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.591
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.529571
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
PDLIM5	Pathway Commons Protein-Protein Interactions	1.0	null
hematopoietic stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
chr18_12717877_A_T_b38	GTEx eQTL 2025	1.0	1.14945
CNOT1	Pathway Commons Protein-Protein Interactions	1.0	null
THOP1	Pathway Commons Protein-Protein Interactions	1.0	null
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933405
BRD-K63864604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13479
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWSA-0226-SM-2XCBA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871685
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58148
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38743
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67149
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.1011
H3K4me1_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
BRD-K97562463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9692
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsomedial nucleus, terminal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57712
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H596	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.11146
EIF3F	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS23	Pathway Commons Protein-Protein Interactions	1.0	null
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23797
MDH2	Pathway Commons Protein-Protein Interactions	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.887646
MCF7_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014991
Retrosplenial area, ventral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03382
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.642269
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6984
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M8-01A-21R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7646
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12834
BRD-A39506880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.008
BRD-K00265832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66999
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.79438
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45168
STON2	Pathway Commons Protein-Protein Interactions	1.0	null
SYK_DEPLETION_GDS3609_36_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NTRK2_drugactivation_66_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.08509
SLC3A2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0327456
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42703
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPSB1	Hub Proteins Protein-Protein Interactions	1.0	null
ABTB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00634051
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977128
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29879
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38652
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72335238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0091
CRCGN015_MCF10A_48H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11674
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984784
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.998395
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
KLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05627
GTEX-XPVG-2726-SM-4B66W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851945
HDAC2	ENCODE Transcription Factor Targets	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04571
RPL14	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K12750296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7821
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36314
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.833681
Perturb_7245_KD_CNOT1_SRP285534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.17424
Thymus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.14
Pluripotent stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K63030320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58531
YES1	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFV2	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11636097_S1249_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K05902089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20714
BRD-K66179451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02373
Infertility, Female	CTD Gene-Disease Associations	1.0	1.08513
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
BRD-K60812542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28196
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2546
4758_MAGEA12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570334
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039571
A549_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122542
GSE165647_5_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BEN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.86481
SKMM2	CCLE Cell Line Gene CNV Profiles	1.0	1.92432
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18495
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bipolar Disorder_Cerebral cortex_GSE12649	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.60931
YWHAH	Pathway Commons Protein-Protein Interactions	1.0	null
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7626
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.521341
mantle zone of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4415
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RSV_4Hour_19459069_GSE3397	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.69795
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.864982
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7980-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.109
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05058
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45239
TFRC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460126
BRD-K41451401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85486
Otulipenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.5601
NEFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28205
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.61685
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33447
XRCC6	MSigDB Cancer Gene Co-expression Modules	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.926247
Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Familial Behcet-like autoinflammatory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
BRD-K77820762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19064
CCNT2	ENCODE Transcription Factor Targets	1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K24997610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49647
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891549
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.182239
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
MRPL13	Pathway Commons Protein-Protein Interactions	1.0	null
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RAP1B	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41057
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZD-43-CS43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277307
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31062
OBF-1_NULL MUTATION_GDS3473_571_mouse_Bone marrow pre-BII cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.984173
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cheek	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
BRD-K35035851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03648
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38111
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0779
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K72501910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27081
BRD-K87990170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53109
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.639527
BRD-K64958595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01789
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99152
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25762
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26602
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.950326
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5396-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287255
BRD-K02334683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31419
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
C3orf38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0909
E2F6	ENCODE Transcription Factor Targets	1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213937
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20699
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45584
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNASEK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64426
MAX	ENCODE Transcription Factor Targets	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.034289
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6475
EIF4H	Pathway Commons Protein-Protein Interactions	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58604
RPUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14332
BRD-K45936761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08902
ITGA5	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9273
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SHFM1	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-U00779237_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatal amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06339
MYC	ENCODE Transcription Factor Targets	1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485591
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202888
BRD-K13390322_HY-50940_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46253
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34278
Prostate adenocarcinoma_PRAD_TCGA-EJ-5519-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PECAPJ34CLONEC12	CCLE Cell Line Gene CNV Profiles	1.0	1.4075
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.66639
Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77173942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51867
Sperm head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
HCV JFH-1_12Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.30351
ASXL1	ChEA Transcription Factor Targets	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3003
CA-42-YI34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287703
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
UA-39-TN76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209063
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09487
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1387
MDA-MB-453 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.20217
PSMB3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85977570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81596
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TORCH syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
PMC8384902-mmc5.xlsx-H889_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
EIF3K	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56034970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19558
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.7333
BRD-K76487707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32236
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.657301
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4487-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Subiculum, ventral part, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21949
CPT1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00393803
BRD-K88960810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13719
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68069
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
negative regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
non-small cell lung cancer cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.6394
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16354
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cloned	GeneRIF Biological Term Annotations	1.0	null
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974175
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JX-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.158677
BRD-K27823380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09297
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	232.233
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	160.215
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395853
BRD-K76337122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51589
BRD-K18268126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50403
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88882
Microcytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.73156
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.114
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FS-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.61379
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896891
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32074
GTEx Brain 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	6.22969
FaDu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ntera2	HPA Cell Line Gene Expression Profiles	-1.0	-0.877584
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909452
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.23797
CE-20-VA70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213286
chaperones	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FDFT1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06023
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JMSU1	CCLE Cell Line Gene CNV Profiles	1.0	1.68252
T-lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55466
Prostate adenocarcinoma_PRAD_TCGA-G9-6498-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27824953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57716
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.7911
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LL-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.881329
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUPT5H	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0534
BRD-K64299311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83342
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01639
BRD-K54079231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68962
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91285
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.041833
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMK1-2226-SM-4B673	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904999
Prostate adenocarcinoma_PRAD_TCGA-M7-A723-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MACF1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.78296
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09806
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2341
YD15	CCLE Cell Line Gene CNV Profiles	1.0	2.51016
urinary bladder	HPA Tissue Gene Expression Profiles	1.0	1.16442
BRD-K11016405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03097
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983598
NC-35-BF58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24865
RNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40624
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14335
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPN1	Pathway Commons Protein-Protein Interactions	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
BST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540042
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.974674
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.26801
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16304302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00186
BRD-K02337960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60823
BRD-K55835264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35876
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.71765
MAP4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12455
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02926
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61733751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62281
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24139
GATA1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.59201
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.993069
BRD-K75135426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76534
Esophageal cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
GTEX-P78B-1026-SM-3NMC4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908071
A498	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.08795
BRD-K84052780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68128
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06855
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.26904
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.51191
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00908
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K47410882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17372
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.938171
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.8177
TFAP2C	ChEA Transcription Factor Targets	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31731
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KALS-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.20817
BRD-K11636097_S1249_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Myositis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
RPL13A	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.968328
BRD-K73044744_KUC104495 KUC104495N_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222119
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95591629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4328
BRD-K47658117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22018
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 2 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15105
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152711
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.11234
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
NHP2L1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.919103
Pigmentation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10298
SEC61B	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HF-00-QG19_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228536
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00895
HIST1H2AA	Pathway Commons Protein-Protein Interactions	1.0	null
SNCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25335
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
zinc acetate_homo sapiens_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19W-06A-41R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142873
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79666
BRD-A30437061_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08709
SIN3A	ENCODE Transcription Factor Targets	1.0	null
MET_knockout_260_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.4229
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	134.939
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.925651
BRD-K72872864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01356
BRD-K13697445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57516
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828989
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92365
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8154
PK1	CCLE Cell Line Gene Expression Profiles	1.0	1.46703
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
BRD-K16705729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45134
Rectum adenocarcinoma_READ_TCGA-AF-6672-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.41159
MYC_Activation - 8 hours_GDS2025_725_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Short Stature	DisGeNET Gene-Phenotype Associations	1.0	null
GSE186633_2_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.938365
BROX	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09143
CL11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33561
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22875
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307131
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344695
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36799
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.896274
ATG12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22416
BRD-K11227160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10532
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052532
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.951617
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50127
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POMP	Pathway Commons Protein-Protein Interactions	1.0	null
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.563
SKMEL24	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22787
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30592
CLTB	Pathway Commons Protein-Protein Interactions	1.0	null
IE-80-DC24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340915
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.322
BRD-K60030763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40179
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.878214
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999394
PPP6C	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875045
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17886576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11833
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USP15	Pathway Commons Protein-Protein Interactions	1.0	null
CMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64123
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.874522
Lung squamous cell carcinoma_LUSC_TCGA-85-8481-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ZFP41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28073
Secretory granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
BRD-K06166879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27015
BRD-K64418159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40895
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
icSARA deltaORF6_12Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.18108
BRD-K47314501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58285
BRD-K85853281_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21172
DB-01-BR68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257065
BRD-K55855103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37478
TCF12/HEB-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.01821
EMG1	Pathway Commons Protein-Protein Interactions	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.6687
ITCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42489
regulation of proteasomal protein catabolic process	GO Biological Process Annotations 2015	1.0	null
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449469
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IE-A6BZ-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
highly	GeneRIF Biological Term Annotations	1.0	null
GTEX-U412-0526-SM-3DB9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3611
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.72803
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22651517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27288
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9058
Dorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35352
brain_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.878428
JUN_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MSN	Pathway Commons Protein-Protein Interactions	1.0	null
RAI14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05213
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09453
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927136
LRRC59	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.589179
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAE1	Pathway Commons Protein-Protein Interactions	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Albedo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18945
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LIMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47321
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23379
Basolateral amygdalar nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39239
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321532
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0426-SM-48FE3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82879
BRD-K57027644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5129
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.921199
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.07482
TE-9	GDSC Cell Line Gene Expression Profiles	1.0	1.46775
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.990764
CTBP2	ENCODE Transcription Factor Targets	1.0	null
LRBA	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4693-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
U2OS	CCLE Cell Line Gene Expression Profiles	1.0	2.51876
BRD-K86073842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83817
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K96491664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81554
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95922469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04116
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.49229
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.6484
Prostate adenocarcinoma_PRAD_TCGA-G9-6329-01A-13R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24350933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53552
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48107
RAC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AC-97-KP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229465
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981653
BRD-K46413323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14889
BRD-K03383196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91451
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78K-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.431388
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.43968
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21004
BRD-K76351135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15496
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24672
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18619710_Digoxigenin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838384
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78232
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14512
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.28776
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-0226-SM-3NB1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04146
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942043
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-5304-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rabies CVS-11_7day-Brain_22116324_GSE30577	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.5821
TET1-21490601-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
spindle checkpoint	GO Biological Process Annotations 2015	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56174
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAF_01_165	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	9.37083
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.0149
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0419
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1155
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Polygenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.144
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78007953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34491
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855548
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ES-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75688032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12778
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18046
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20981
BRD-K60751806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37168
BRD-K25484053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01455
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RCC2	Pathway Commons Protein-Protein Interactions	1.0	null
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.694074
PMC7617804-EMS206527-supplement-Document_S2__Article_plus_supplemental_information__.pdf-28-KCMF1_KCMF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08134
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73672
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35731
BRD-K50977435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21122
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
SP1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51447
PRKAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13099
Gastrointestinal system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71061
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
estradiol_homo sapiens_gpl96_gse4668	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24596
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68909
obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.243995
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	107.785
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50596
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.53862
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.2846
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.457
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K55562948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04655
Trichohepatoenteric syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33847
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37942
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1049
BRD-K24946605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68342
BC-72-DZ30_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417216
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5139
Supramammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20717
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03791
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3209
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K79807180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4481
UBE2M	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80066561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82402
GT3TKB	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU182	CCLE Cell Line Gene CNV Profiles	1.0	1.44915
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316154
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.532955
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24262
Corpus epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37239
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33594
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44052748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15251
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01526
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40159
LS411N	CCLE Cell Line Gene Expression Profiles	1.0	1.62915
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
5955_OR4K1_ENST00000285600.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.511392
GATA3	ChEA Transcription Factor Targets	1.0	null
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28179
RAD21_02_190	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58951
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980026
S0-EE-Y7IR_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20171
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37974
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314455
BT483	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51635
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14261
NUP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24482
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NAPA	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137907
GOTO	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.43715
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0519
RPA2	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hacat	HPA Cell Line Gene Expression Profiles	-1.0	-1.1619
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862879
GSE172146_2_v_1_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
19096012-TableS2	GeneSigDB Published Gene Signatures	1.0	null
FOXM1-25889361-OE33-AND-U2OS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CB-32-EI69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27898
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
17616640-TableS3	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
U20S	BioGPS Cell Line Gene Expression Profiles	1.0	1.16103
leukocyte disease	GWASdb SNP-Disease Associations	1.0	0.274186
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.26904
proteasome assembly	GO Biological Process Annotations 2015	1.0	null
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26423
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250249
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
IDI1	Pathway Commons Protein-Protein Interactions	1.0	null
IGF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18485
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.58165
DoTc2-4510	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.69738
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268883
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57688676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04483
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850092
ESYT2	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38648
CRCGN017_MCF10A.WT.HP_24H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11223
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33775
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64451058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36753
ACHN	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.97525
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Esophageal carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.456
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
regulation of cell cycle phase transition	GO Biological Process Annotations 2015	1.0	null
CORO1B	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01216
NUP210	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sweet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.88431
liver	GeneRIF Biological Term Annotations	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29693
SKMEL28	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.83304
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91579
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399632
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.945206
Acute Myeloid Leukemia_LAML_TCGA-AB-2921-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258904
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865262
EIF2S3	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of cell death	GO Biological Process Annotations 2015	1.0	null
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.034
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02584
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57732605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28414
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2277
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.40045
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40285
KG1C	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6182
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cancer	GWASdb SNP-Disease Associations	1.0	0.051619
MAX	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51028
ERBB2_druginhibition_8_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77909
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.722
PMC8527296__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K91191855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09325
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86165
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82292504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33311
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K88274759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24548
presubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48372
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0819
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12099407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12189
U2AF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961708
PDCD5	Pathway Commons Protein-Protein Interactions	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857559
SUIT-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20981
METTL21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18163
perimammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19424
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.594355
Dopaminergic A13 group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08906
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279968
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34166
Ire1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.248
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.70014
basolateral nucleus (basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.858819
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49782
Severe combined immunodeficiency with sensitivity to ionizing radiation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
BRD-K16485616_mocetinostat_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS26	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02712
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.10604
NCKAP5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37783
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K41729242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19858
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76267
liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.266203
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.94834
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040028
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05146
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07861364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12154
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.56072
pac2	GeneRIF Biological Term Annotations	1.0	null
BRD-K52436508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05006
KPNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00819
root	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.371619
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51912
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350737
9+2 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.937
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26654
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A60245366_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.845067
GSK3B_KD_GDS4305_183_human_THP-1 acute myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A71459254_CYMARIN_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.979035
MOLT-13	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07646
ALPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506936
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26351062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09442
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.579612
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09169
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-54-JC89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25504
Cortical subplate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11754
liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.254536
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19081
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KJ-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21955
AB-17-WP43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228126
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863934
anthraquinone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43754
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040542
BRD-K79090631_CGP-60474_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.35419
BRD-K03344897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38337
PRMT5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K12593465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32969
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.137752
OLA1	Pathway Commons Protein-Protein Interactions	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-A35871558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10865
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32514
BRD-K74506898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01332
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40324
PGK1	Pathway Commons Protein-Protein Interactions	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38771
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9813_KD_CNOT3_SRP117693	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.0761
Basal ganglia calcification	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.822
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849058
BRD-K05950670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52054
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CJ-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HIV - Human immunodeficiency virus infection_T lymphocyte_GSE6740	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.2641
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.746875
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27121064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22384
MHH-CALL-2	GDSC Cell Line Gene Expression Profiles	1.0	3.29797
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52016
BRD-K36760124_Lanatoside C_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600437
BRD-K12640996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12802
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21955645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38994
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17621
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-24	GDSC Cell Line Gene Expression Profiles	-1.0	-1.99037
proteasome	GeneRIF Biological Term Annotations	1.0	null
ARL2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K27011412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61606
Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20795
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ML1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.96771
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05115
HMGN3	ENCODE Transcription Factor Targets	1.0	null
GRPEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15479
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.503174
submammillothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23708
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16754
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01237277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13931
LYSP100-associated nuclear domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.352598
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050185
BRD-K48145537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09658
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.05953
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22959
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40263
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03312
PF-382	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.71095
JHH1_LIVER	CCLE Cell Line Proteomics	1.0	4.70896
PFAPA syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
BRD-K13390322_HY-50940_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.24038
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
17682054-Table1	GeneSigDB Published Gene Signatures	1.0	null
lung disease	GWASdb SNP-Disease Associations	1.0	0.182239
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-let-7c-5p	MiRTarBase microRNA Targets	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.624409
S0-EE-YC7H_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259108
GTEX-W5X1-2526-SM-3GILC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926768
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
A549_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140608
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837575
BRD-K72255851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65975
RBBP5	ENCODE Transcription Factor Targets	1.0	null
BRD-K82571240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24172
BRD-K89175823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22057
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.137
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.37635
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58149231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58571
superficial stratum of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00486
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0192
ALL-PO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43078
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902926
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59701963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07292
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342691
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56908
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46395
external segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04861
Brucellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21774
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20223
adult stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NRL_Deficiency_GDS1693_237_mouse_Photoreceptors cells of retinas at P6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-S32W-2226-SM-2XCAY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29606
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19896
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38072
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-ChIP_and_HES4_UP_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18026
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.00731
GATA3-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.11229
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15867
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320316
Epirubicin (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00650099
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.24592
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205959
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882022
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASXL1-24218140-BMDM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SF-0426-SM-3K2B7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826458
lymphoma	GWASdb SNP-Phenotype Associations	1.0	0.439838
Entorhinal area, medial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54204
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.895105
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.33854
CCDC121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05777
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DF-84-RT50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302652
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
A-CA-04-2009(H1N1)_Day1_22532695_GSE36328	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52394
BRD-K98578493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15744
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92344227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1704
Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50140257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11619
DAB2	Pathway Commons Protein-Protein Interactions	1.0	null
troxerutin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22582
SKMEL31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46268
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A16827030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14096
ATP2C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00292203
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.773
BRD-A46747628_Ouabain_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGW	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45851
VASP	Pathway Commons Protein-Protein Interactions	1.0	null
CC-90-EX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325247
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154794
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40442
Prostate adenocarcinoma_PRAD_TCGA-G9-6364-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84815485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38398
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14745
BRD-K59272984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11744
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HADHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671293
BRD-A69786436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.116
BRD-K63856509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09072
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16403
MCF7_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191319
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51573654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.292
BRD-A76904477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48198
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927649
BRD-K43909206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79313
Viral cardiomyopathy_Myocardial tissue_GSE4172	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.53766
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04136
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1365
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
lymphoma	GWASdb SNP-Disease Associations	1.0	0.51563
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
AP2A1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-559	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20076
BRD-K08442552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44283
MLLT4	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.909561
medial intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02971
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_3567_KD_CA2_SRP336886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
DDX47	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1847
VPS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79437
BRD-K12492021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92325
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	HPA Tissue Gene Expression Profiles	-1.0	-0.870581
RAD21_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32363
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LK-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80122
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05916
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K25236390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26626
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88544
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ED-43-XF39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224765
regulation of metaphase/anaphase transition of cell cycle	GO Biological Process Annotations 2015	1.0	null
GALE	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77663497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26802
BRD-K79090631_CGP-60474_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33902
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934823
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.165532
CRCGN017_MCF10A.WT.HP_24H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.281
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26314
PMC9691391-7945884.f3.pdf-276-ENSG00000134954_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSTK1	Pathway Commons Protein-Protein Interactions	1.0	null
Parasubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12551
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14269
BRD-K53257307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36951
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	1.0	0.858581
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08428
BRD-K64111129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1888
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16744
HC-63-SV27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311556
C2BBe1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.86159
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25895
STAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0137458
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05247
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.42363
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36909
TGM2	Pathway Commons Protein-Protein Interactions	1.0	null
ME-54-JY76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317785
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67912
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SNU899	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60694
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.20719
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50248
BRD-K88662980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22481
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01197
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMB2	Pathway Commons Protein-Protein Interactions	1.0	null
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
CACYBP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K48266244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21749
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06947
GA-04-JM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272014
BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K57228212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50694
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475934
mantle zone of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26329
BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46235
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.6334
OSRC2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55135
CF-24-KQ98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293872
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83236
KB-78-BE93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385635
BRD-A84913188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44296
Perturb_3643_KO_DNMT1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.1765
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12674
FOXD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01972
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.63167
BRD-K69671285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14143
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37942
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93628
hsa-miR-100-5p	MiRTarBase microRNA Targets	1.0	null
PATU8988S	CCLE Cell Line Gene Expression Profiles	1.0	1.34722
YTHDF2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-1013-FOXK1_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.993069
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.893213
BRD-K08811598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02758
subcallosal cingulate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.932422
GSE141624_3_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24403
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
immune system disease	GWASdb SNP-Disease Associations	1.0	0.045862
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.894343
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276636
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33324
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM33_KD_GDS4071_449_human_HMEC-TR mammary epithelial cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6837
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF212	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516749
Mitochondrial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562077
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421661
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.676
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAB11B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.22512
FAU	Pathway Commons Protein-Protein Interactions	1.0	null
protein-containing complex assembly	GO Biological Process Annotations 2023	1.0	null
BRD-K00853706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6042
medial part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26396
mantle zone of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15105
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.56928
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14288
Liver And Intrahepatic Biliary Tract Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243084
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584607
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.081026
SARS-CoV_72Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.43737
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.26904
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Entrectinib_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00829785
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.647
ChIP_MYC_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TCCSUP_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	3.72841
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitotic cell cycle process	GO Biological Process Annotations 2015	1.0	null
BRD-K92849826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40848
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33596
Perturb_7494_KD_DICER1_SRP186271	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.74316
negative regulation of cell cycle	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04113
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
FARSB	Pathway Commons Protein-Protein Interactions	1.0	null
BF-29-LU75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261882
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88835
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12967
BRD-M16762496_S1205_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_6412_KO_TP53_SRP274402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.71564
MET_knockout_258_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.76745
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96724
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRN-0226-SM-2I5EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09124
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.903435
negative regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K34482448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38827
negative regulation of mitotic cell cycle	GO Biological Process Annotations 2015	1.0	null
USP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14654
BRCA1_DEPLETION_GDS2189_121_human_MCF10A mammary epithelial cells (MECs)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AF-12-IW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388173
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
Male pronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.07
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NAP1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54824
superficial stratum of PaS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41212
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
NTRK3_drugactivation_67_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.08509
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3308-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02558
Pyoderma gangrenosum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1387
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-2526-SM-3DB7V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876777
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAPA syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465403
NCIH1341	CCLE Cell Line Gene CNV Profiles	-1.0	-2.70283
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930852
EW-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46916
BRD-K22508525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20506
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9282
BRD-K19266588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.202
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A18497530_EI-293_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K88613983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15046
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.754977
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261885
KLM1	CCLE Cell Line Gene CNV Profiles	1.0	1.68615
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0154
HMGB1	Pathway Commons Protein-Protein Interactions	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.574724
proteasome assembly	GO Biological Process Annotations 2023	1.0	null
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51107
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36591
GSE157960_2_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65392756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3158
layer 5 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25391
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946844
BRD-K91585756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25379
IRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19187
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.826141
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89708
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44339278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7246
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7230-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.329
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.61203
Juvenile rheumatoid arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR5	BioGPS Cell Line Gene Expression Profiles	1.0	1.03692
bladder	GTEx Tissue Gene Expression Profiles	1.0	0.985567
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07843
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
chaperonin-containing T-complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.773
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28308
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.689873
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K47083242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81573
GTEX-TMMY-0726-SM-33HBE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19373
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03074
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.471274
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11959
chrysophanic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32553
AB-71-CI37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22396
ZW10	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08906
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2402
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33795
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.043026
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03525
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16061
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77931
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20845
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.991565
regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8854
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81701
BRD-K70357895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38994
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522579
Perturb_14896_KO_H13_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.19822
intermediate stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47524
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intercalated amygdaloid nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48372
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.907353
BRD-K16852474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4461
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6448
RPL7	Pathway Commons Protein-Protein Interactions	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2582
GTEX-TML8-2026-SM-32QOP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04781
assembling	GeneRIF Biological Term Annotations	1.0	null
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-1.26904
SEC22B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K94728263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0565
MTFMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62128
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
964_C12ORF45_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.554259
QGP-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.87163
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45071
Perturb_6414_KO_TP53_SRP274402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.74582
BRD-A45498368_HY-10044_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.1674
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.7931
baf8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K41993678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14497
Brain Lower Grade Glioma_LGG_TCGA-DU-7010-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.66849
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.942216
Brain Lower Grade Glioma_LGG_TCGA-VV-A829-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9237085-41467_2022_31238_MOESM4_ESM.xlsx-Table_4_MYC_BC_signature-HGNC_symbol_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X5EB-2426-SM-4E3HX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12881
Trichohepatoenteric syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.718
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.5241
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24394
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233297
Posterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54204
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36109
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	168.894
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40421
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69994
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917709
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17986
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alzheimer's Disease_Entorhinal cortex_GSE5281	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.32779
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128074
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.52382
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.52505
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388291
CRCGN015_MCF10A_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03637
layer 1 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62441
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834608
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.639
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01783
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr18_12722968_C_T_b38	GTEx eQTL 2025	1.0	1.63381
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31971
Combined oxidative phosphorylation deficiency 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
proteasome-associated autoinflammatory syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.915
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.935978
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial part of r3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03086
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68317
Lung adenocarcinoma_LUAD_TCGA-50-7109-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.0662
GB-96-WX99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24959
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12362
TD-69-UA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341066
BRD-K53127431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16364
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-19	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65371
1513_CEP76_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.750559
MED17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17638
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40228963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60839
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Proteasome-associated machinery	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
BRD-K45091989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21698
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11162
P30-OHK	GDSC Cell Line Gene Expression Profiles	1.0	1.46826
AP2A2	Pathway Commons Protein-Protein Interactions	1.0	null
PPM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22105
BRD-K47326075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31027
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-CoV_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.13486
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26093
GLUD1	Pathway Commons Protein-Protein Interactions	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IFIT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523439
COLO849	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85003
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chaperone-mediated protein complex assembly	GO Biological Process Annotations 2025	1.0	null
SNU-C4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
regulation of nuclear division	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12871
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02142
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72694472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21753
negative regulation of cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K19389825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27989
Presubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15105
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.79034
YWHAG	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891506
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28147
Digenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.217
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTV-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.47411
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3762
mantle zone of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41212
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23056
BRD-K86964464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81906
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
KRT31	Pathway Commons Protein-Protein Interactions	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.9507
Perturb_15645_KO_Tet2_SRP255385	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0014
BRD-K87044635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45051
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.763552
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77209
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89202
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49052
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A8O8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
decitabine_homo sapiens_gpl571_gse29077	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88955
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930014
BRD-K03606830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98485
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13716
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.44376
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FGFR2_activemutant_59_GSE17916	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.59628
dorsal subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03487
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-1326-SM-3GIJC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902228
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25911
GSE95685_2_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Aicardi-Goutieres syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.922
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10298
NDUFA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26636241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00374
BRD-K67689282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01521
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281628
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.922854
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1277
GATA2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tegmental reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17309
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920923
salicyl-alcohol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06021
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PIK3CA_activemutant_56_GSE17785	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.1145
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896738
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42545
BRD-K90749965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5099
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857559
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4159-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.722085
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94X-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456722
MCF7_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165763
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5332
Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.13414
SOX2	ChEA Transcription Factor Targets	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTBP1-25329375-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927649
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MEIS1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221401
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82193
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2521
BRD-K11474067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03444
BRD-K61973443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46171
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A2KB-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.61379
BRD-K53088255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45639
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MM-2	GDSC Cell Line Gene Expression Profiles	1.0	1.48874
BRD-K69074358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33734
TCF12	ENCODE Transcription Factor Targets	1.0	null
BRD-A93236127_DIGITOXIN_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34595206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05274
EP300	ENCODE Transcription Factor Targets	1.0	null
HC-01-FD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235428
BRD-K09100418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1476
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.816097
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.081026
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18841
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09854
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1136
Hypothyroidism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.255
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84996
Adult Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Hematopoietic cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
intermediate stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14186
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224071
BA-97-CI76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226779
intermediate stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32325
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8042-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eltanolone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83229
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99894
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77497
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88079
PEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07006
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870207
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16423883-Table1S	GeneSigDB Published Gene Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Muckle-Wells syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
PC-80-LV29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205098
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829426
Basolateral amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30815
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-72-DZ30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242215
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13204142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02261
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-Zhu_2016_-_MLL-AF4-Non-spreading_targets_gene_names_262_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515049
CRCGN009_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08764
AP5S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56059
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29779
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
Ooplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
form	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23796
PMC6412103-mmc1.docx-5-M00695_ETF_P_8_350E-5_N_428_31_5_1_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36731
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8662-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adult stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994084
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.992617
BRD-K40361885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70136
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80898
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32854540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48812
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23275
biological regulation	GO Biological Process Annotations 2015	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.476955
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0342
Retrosplenial area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0482
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58879
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42264
SMCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173793
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF224	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05531
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DE-99-OT37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342857
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10847
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305231
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GDI2	Pathway Commons Protein-Protein Interactions	1.0	null
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	188.477
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCEAL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10338
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12604
MHHCALL2	CCLE Cell Line Gene CNV Profiles	1.0	1.34701
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.992099
CAP1	Pathway Commons Protein-Protein Interactions	1.0	null
cingulate gyrus, frontal part, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06103
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81619
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56689
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455729
BRD-K60948317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74012
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18865369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04409
STMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10895
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K68618894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20212
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11271
ACOT13	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5441-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9111_OE_FOXO1A3_SRP188991	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.13091
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4524
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89222
BRD-K97263385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01733
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus of the brachium of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58006
BRD-K36764343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25307
ventral subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21949
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206198
Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LA-44-KW22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250681
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3823_HMG20B_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579741
KYSE450	CCLE Cell Line Gene Expression Profiles	1.0	1.37029
hela	HPA Cell Line Gene Expression Profiles	-1.0	-1.90944
LCP1	Pathway Commons Protein-Protein Interactions	1.0	null
TMEM89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06319
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235522
PMC3874167-supp_gkt849_Supplement_Table_S1.xls-DREAM_-_unclear_TSS_affiliation-Gene_name_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0426-SM-3NMCI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892413
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261109
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.907627
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.6807
CPSF7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04455
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20227
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38793
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48257
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322055
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28044
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60084
fulllength	GeneRIF Biological Term Annotations	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDAP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
dorsomedial tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09656
Lung squamous cell carcinoma_LUSC_TCGA-94-A5I4-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-8253-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58414
BRD-K69585439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03061
Perturb_9110_OE_FOXO1A3_SRP188991	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.2384
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65108634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60183
GTEX-SUCS-1826-SM-32PM1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997859
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
Ulcerative colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.647
EIF5B	Pathway Commons Protein-Protein Interactions	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13688
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91297952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12318
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91587
16622258-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25983
ARPC4	Pathway Commons Protein-Protein Interactions	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.8623
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564402
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02132
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.354
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.695681
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48499
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22886
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226928
BRD-A49544621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72955
DIMT1	Pathway Commons Protein-Protein Interactions	1.0	null
Combined oxidative phosphorylation deficiency 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883152
PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K76350099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69569
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200634
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05351
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZM-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971965
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02446
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.604414
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1303
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.993555
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18175
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053898
PA2G4	Pathway Commons Protein-Protein Interactions	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79887921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50902
BRD-K43820045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26329
Perturb_9085_KO_YAP_SRP297717	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32952
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918612
BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366116
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERFLCAI	CCLE Cell Line Gene Expression Profiles	1.0	2.12391
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperimmunoglobulinemia D periodic fever syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
BRD-K87176777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8253
H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
Mevalonic aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
RAD21_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.4966
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74772
medial part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43217
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AP2B1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sperm flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.036
Supramammillary nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20056
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3456
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99736408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05648
BRD-K72745710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62294
DB-41-IH69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27764
BRD-K02053819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61754
CRCGN008_HEPG2_24H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1983
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48288
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70578146_dactinomycin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30591
Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26935
BRD-K05549170_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5045-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ILK	Pathway Commons Protein-Protein Interactions	1.0	null
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.084401
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ACTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27246
vitamin c_homo sapiens_gpl6884_gse16590	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12548
BRD-K01240438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03883
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7473
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.84212
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72207
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17063694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22581
BRD-A73909368_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50128
Blau syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-0.832828
Type 2 diabetes mellitus_Hepatic Tissue_GSE2899	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.48544
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17794
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5170-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00031
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956717
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.668095
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5683
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052537
BRD-K64822626_KUC104135 KUC104135N_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K46085646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7954
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1649
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of mitotic metaphase/anaphase transition	GO Biological Process Annotations 2015	1.0	null
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47113
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12551
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCI-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S341-2026-SM-2XCAA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15695
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58375
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colon muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
BRD-K11636097_S1249_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95858622_NCGC00182609-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826658
substantia nigra reticulata, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21328
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295034
intermediate stratum of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00929
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28816
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.948305
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80296876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31225
Perturb_8450_KD_NPM1_SRP230777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.63407
BB-55-JH29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313127
GTEX-UPIC-1526-SM-4IHLU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829458
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55652
RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31585
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24621
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15067
neuro2a	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.35432
BRD-K05181466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30567
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26655
NAPG	Pathway Commons Protein-Protein Interactions	1.0	null
WB-82-EL69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282249
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26061
NACA	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33731
MYOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09683
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507383
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.845658
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856556
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09439
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215024
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14558
1910_CSRNP3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515916
GSE154069_2_v_4_satb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.97764
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.581149
Lymphocytic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
BC-72-DZ30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239027
ROCK_INHIBITION_GDS3944_462_mouse_Forebrain astrocytes - 6 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of mitotic sister chromatid segregation	GO Biological Process Annotations 2015	1.0	null
PSMB5	Pathway Commons Protein-Protein Interactions	1.0	null
inferior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888053
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00085
BRD-K36709933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32943
BRD-K01212001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30565
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.860123
posteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48372
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30995
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cell cycle	GO Biological Process Annotations 2015	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23056
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.18391
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257005
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17921
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18425
BRD-K89767945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49526
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09662
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051191
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.83454
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.911073
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09065
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03308
SCRIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19652
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-LI-A9QH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25516
Perturb_14627_KO_OGT_SRP146064	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.55133
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150081
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.356
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	3.19194
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828715
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07502
IRS4_KO_GDS1219_306_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SA-03-IQ14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208714
breast	GTEx Tissue Gene Expression Profiles	1.0	1.10902
BRD-K22481359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92387
Proteasome assembly	Reactome Pathways 2024	1.0	null
Blood cancer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
TET1-21490601-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K09232527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23742
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850003
BRD-A73909368_DACTINOMYCIN_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20908
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.866328
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65M-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SS-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-2126-SM-4JBJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09541
ZYX	Pathway Commons Protein-Protein Interactions	1.0	null
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.647
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94521090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01284
TET1	ChEA Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IA-27-CK10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339845
TCF3	ENCODE Transcription Factor Targets	1.0	null
MONO-MAC-6	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.14048
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.334
cdna	GeneRIF Biological Term Annotations	1.0	null
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC25A1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.698721
layer 5 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31731
BC-26-LE04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435108
BRD-K07836769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35462
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.07111
GSTO1	Pathway Commons Protein-Protein Interactions	1.0	null
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206115
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39042
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2569
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09353
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35854
binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08867
BRD-K87909389_HY-10005_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7M4-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38039
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
BRD-K46445956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64131
GATA1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K-562 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	2.06399
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.002
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231092
Fetal Death	CTD Gene-Disease Associations	1.0	1.29812
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.932581
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14144
MAX_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A57536034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35944
PMC11947124-41419_2025_7562_MOESM1_ESM.docx-175-E2F6_E2F6	Rummagene Transcription Factor Associations 2026	1.0	null
OV56	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45948
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.67627
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47903
BRD-K05777604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33058
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17763