association	dataset	threshold value	standardized value
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DDX25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74553
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
HDLM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84714
precuneus, left, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1614
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.826
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258927
Perturb_13976_KO_H3f3a/H3f3b_ERP109384	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.56523
kidney	HPA Tissue Gene Expression Profiles	1.0	1.87419
Lung squamous cell carcinoma_LUSC_TCGA-22-5483-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06557
GSE178532_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.73863
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36106
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999348
HSPB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628681
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.37242
PYCR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.05096
BRD-K92767663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06326
parathyroid hormone receptor activity	GO Molecular Function Annotations 2023	1.0	null
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-ID_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40559
each	GeneRIF Biological Term Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02869
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83337
PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
TMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70805
Lung squamous cell carcinoma_LUSC_TCGA-22-5477-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9794
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07805
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064235
K562_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0333865
BRD-K62795540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1089
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46418
ESR1_KD_GDS4061_453_human_MCF7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRCA1_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
N6-methyladenosine-1271	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
S100Z	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622734
cerebrovascular disease	GWASdb SNP-Disease Associations	1.0	0.573738
IRAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598994
K562_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0673613
PXMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1449
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06324
Pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
[Ile<sup>5</sup> Trp<sup>23</sup>]PTHrP-(5-36)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172249
within	GeneRIF Biological Term Annotations	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92229
BRD-K97373334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68434
BRD-K86946907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44615
hsa-miR-524-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.41595
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-7848-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04361
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08234
class	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASH-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74814
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.43184
Mouselcells	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
SKES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47105
Nephrolithiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.51086
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06037
SF3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47493
ST6GAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57628
Brain_CT2_Thex 372	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
ADAM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34279
Perturb_14982_KO_Setd1a_SRP330236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.72175
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31673
CELF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611455
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.514
K562_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139506
BNIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3401
MYO3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639298
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8643
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
D-566MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.82076
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21028
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40982
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39401
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K27476515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23887
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parathyroid hormone secreting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.236
HS695T	DepMap CRISPR Gene Dependency	1.0	6.7955
BMI1-23680149-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.038591
LONP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35749
BRD-K80381603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24931
EZH2	ENCODE Transcription Factor Targets	1.0	null
Hmgn1_KO_GDS5010_406_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
TIP39-(7-39) (mouse)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
C80	DepMap CRISPR Gene Dependency	1.0	6.77612
CRCGN015_MCF10A_48H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2439
BRD-K96280720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88256
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7741
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52876
provide	GeneRIF Biological Term Annotations	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88188
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	116.705
Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71982936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0514
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976311
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21469
hydralazine-2349	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237902
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169001
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8600817-12951_2021_1120_MOESM2_ESM.xlsx-Table_S4-Table_S4_Pan_PPAR-iMSC-EV-induced_differentially_expressed_genes_in_fatty_acid-treated_HepG2_cells_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258067
SPTY2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11277
BRD-K10048365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06169
trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.784388
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.7265
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307562
hsa-miR-4764-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VU-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040522
signal transduction	GO Biological Process Annotations 2015	1.0	null
Bone resorption disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.969
ischemic bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.653671
ML-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K64055457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55927
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.883602
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143203
PMC8554124-DataSheet2.XLSX-23-TBX18_TBX18	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77465015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86633
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04802
TLNRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28538
kidney_b	HPA Tissue Sample Gene Expression Profiles	1.0	1.97313
COLO201	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46186
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.40842
H2804	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.938944
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26062
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.20031
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829465
Exine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.615
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0732
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0281
VASH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57152
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830939
LN235	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.46742
BRD-K76492619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09394
lung cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
hsa-miR-124-3p	MiRTarBase microRNA Targets	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876486
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.5191
Class B/2 (Secretin family receptors)	Reactome Pathways 2024	1.0	null
Superior colliculus, zonal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16633
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7086-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNASEH2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632706
BRD-K36368568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.05991
GPCR, family 2, secretin-like	InterPro Predicted Protein Domain Annotations	1.0	null
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163677
DDX42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24594
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52803
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	Reactome Pathways 2014	1.0	null
BRD-K44494409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35663
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
r5 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14876
CEBPB	ENCODE Transcription Factor Targets	1.0	null
regions	GeneRIF Biological Term Annotations	1.0	null
NTPCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07919
K562_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286411
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.566828
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200029
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.94846
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48232
NCOA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064529
GTEX-XQ3S-1326-SM-4BOPQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12777
BRD-A28970875_PUROMYCIN HYDROCHLORIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86273
CSNK1G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56305
CRCGN015_HEPG2_48H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1244
intermediate stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09923
BRD-K72034944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98914
ARHGEF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41676
IKBKG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575959
JEG3	DepMap CRISPR Gene Dependency	1.0	2.21157
Saethre-Chotzen syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.061655
BMI1	ChEA Transcription Factor Targets	1.0	null
BRD-K70843862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75814
PMC9035581-HEP4-6-1157-s002.docx-3-Supplementary_Table_S5_Gene_expression_signature_of_endogenous_FOXS1_silencing_in_SNU-449_cells_FOXS1	Rummagene Transcription Factor Associations 2026	1.0	null
Amylin receptor complex 3	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.237
BNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07189
hsa-miR-103a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.266
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.072935
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVTOKO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44423
retina	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prestwick-967-2925	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64567246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66788
pth1r	GeneRIF Biological Term Annotations	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_A-GeneName_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
EIF5AL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47392
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00752
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.742338
Class B/2 (Secretin family receptors)	Reactome Pathways 2014	1.0	null
U87MG	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04559
neuroactive ligand receptor interaction	KEGG Pathways	1.0	null
Outer mantle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A56427952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08226
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.417685
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.089973
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Zona incerta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.648
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.84862
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Nearest_Ensembl_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IL26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623046
TUBA1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35473
anxiety	GeneRIF Biological Term Annotations	1.0	null
BRD-K53026281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2708
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM242	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52712
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-EGR2-Unnamed_0_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-NI-A8LF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A115-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241787
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235097
SIRT4_KO_GDS4823_22_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RHOV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533339
UACC893	CCLE Cell Line Gene Expression Profiles	1.0	1.94931
Lung squamous cell carcinoma_LUSC_TCGA-94-A5I4-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07185
BRD-K77634878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71006
K562_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020696
BRD-K13673722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33346
Lateral amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.216
[Ile<sup>5</sup> Trp<sup>23</sup>]PTHrP-(4-36) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K08702524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35936
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTNNB1_OE_GDS4449_352_mouse_Embryonic kidney from E12.5 embryos (-catGOF-UB mutant)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ALDH7A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04224
BE2-M17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IGFBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00428503
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCC4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38036
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14971
KMH-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PTH2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r1 part of superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17606
ventrolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.861806
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19384
BRD-A96791331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19335
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874039
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20131
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Ebolavirus(EBOV)_1day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.73703
PRSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00464639
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18847
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0570292
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lenalidomide (hemihydrate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0246329
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
teriparatide	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Parafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25129
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.30505
BRD-K86584551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67164
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201378
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939117
Uropygial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
Fetal Death	CTD Gene-Disease Associations	1.0	1.11877
BRD-K15478481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19496
RHOBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68236
Brain_CT2_EMSN 229	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22493
PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1599	CCLE Cell Line Gene Expression Profiles	1.0	2.5174
RD	CCLE Cell Line Gene CNV Profiles	1.0	2.84562
Lateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48984
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5059470-ncomms12992-s6.xlsx-CRS-NOCRS-Supplementary_Data_5_Integration_Frequency_in_cirrhotic_CRS_and_non-cirrhotic_no-CRS_Tumor_Samples_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	1.68898
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ebolavirus(EBOV)_7day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.4604
BRD-K87082948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40651
K562_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0384811
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85J-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024926
BRD-K96288607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20613
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43562
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65472
Anterior commissure	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.805
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2651
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.54424
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
RGS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651515
mantle zone of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05092
lateral amygdaloid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44177
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.863
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889827
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1599	GDSC Cell Line Gene Expression Profiles	1.0	1.76356
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.82736
BMPR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554413
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.865
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NUF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43648
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.95854
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	1.22407
BRD-K34804325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14346
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5332-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.071796
icSARS-Cov_Day1_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.86932
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.728182
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1014
[<sup>125</sup>I][Nle<sup>8 21</sup> Tyr<sup>34</sup>]PTH-(1-34)-NH<sub>2</sub> (rat)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00408891
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.924516
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.841608
K562_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0850995
GTEX-WEY5-0726-SM-4LMID	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855509
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LETM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03235
Liver hepatocellular carcinoma_LIHC_TCGA-BD-A2L6-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18557
YY1AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11286
anterodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83001
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2662
BRD-K78972225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21303
ZNF367	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55612
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00510018
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77504251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43391
Thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.839
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPRD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33586
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16985
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4901-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0355462
K562_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02258
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23904
Prostate adenocarcinoma_PRAD_TCGA-VP-A876-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162662
Rutin (trihydrate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0191721
ANXA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22282
GSE139966_4_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM86A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31676
BRD-A28219573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63505
GSE147366_3_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5571
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999348
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
intermediate (interpositus) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87289
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C18orf21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0916
DICER1_KO_GDS4504_585_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Calcitonin family receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.63
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.996012
hsa-miR-4680-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
overexpression	GeneRIF Biological Term Annotations	1.0	null
BRD-K04092807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57196
inner SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44156
extracellular region part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044453
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56021
Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0551659
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73858940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10623
MCRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31524
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.961183
rat	GeneRIF Biological Term Annotations	1.0	null
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-TML8-1226-SM-32QON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28471
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KY821	GDSC Cell Line Gene Expression Profiles	1.0	2.15365
VMRCLCD	CCLE Cell Line Gene Expression Profiles	1.0	1.66918
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29897
infundibulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.682287
BRD-K57650037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80095
BRD-K53617314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2659
RHBDD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40313
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02775
UBE2D3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060216
auditory vesicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.518465
BRD-K55508908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66117
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39273
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02339
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.621428
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08467
supramarginal gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.96465
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37136
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.92268
Entorhinal area, medial part, dorsal zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90332
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36155
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25896
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K74216068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14596
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56021
Median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.609
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06281
collagen type ii trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.209169
DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.863786
[Ile<sup>5</sup> Trp<sup>23</sup>]PTHrP-(3-36) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43586
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.646505
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01078
hsa-miR-3123	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GSE128730_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6992-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.084
superficial stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4054
ESPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00622
PRSS36	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00638279
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
RCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78495
GPCR, family 2, extracellular hormone receptor domain	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K19930413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10713
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.950742
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.72715
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03376
respiratory system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
Anorexia	CTD Gene-Disease Associations	1.0	1.10069
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01847
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4124
C32	CCLE Cell Line Gene CNV Profiles	1.0	1.5681
HERPUD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60822
primary somatosensory cortex (area S1, areas 3,1,2)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00494
BRD-K09875820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03413
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0608409
Entorhinal area, medial part, dorsal zone, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20474
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499241
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8918
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.292897
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83293
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.78554
UBE2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46632
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ovarian epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.963231
BRD-K20745677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18579
amygdaloid complex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.9166
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_EA-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.684692
H3K4me1_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ER_ZNF_GATA3-Gene_Name_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
RNF214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82647
K562_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252657
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53631
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06323
[ILE5,TRP23]PTHRP-(2-36) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.922744
[Trp<sup>23</sup>]PTHrP-(1-36) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K24864035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46946
CHD2	ENCODE Transcription Factor Targets	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055934
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.82673
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	1.0	1.03005
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-EGR2-ID_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
ALAS2_OE_GDS2118_74_human_Blood	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.00407
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.084045
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00984
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0738
Rimonabant_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258533
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HNT34	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.45898
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0S7-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59751
SMC3	ENCODE Transcription Factor Targets	1.0	null
Calcium metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.817
PDLIM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59669
BRD-A55408860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01812
PMC9130782-Table_3.xlsx-downregulated-ZNF366_ZNF366	Rummagene Transcription Factor Associations 2026	1.0	null
K562_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225909
stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01637
ATP5MGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33349
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81204
TIP39-(7-39) (MOUSE)	DGIdb Drug Targets 2026	1.0	1.7644
Osteochondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
g-protein coupled receptor activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32544
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939082
BRD-K62572662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28088
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.29209
NCI-H520	GDSC Cell Line Gene Expression Profiles	1.0	1.52315
SIRT4_KO_GSE56321_391_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27857
Neurohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.493
Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
internal granular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55536
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K54478142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66331
EXOSC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46223
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTHrP-(1-34)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36106
biological_process	GO Biological Process Annotations 2015	1.0	null
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064536
BRD-K95927760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12477
BRD-K94744294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11042
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.36338
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37596331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24804
OLIG2	ChEA Transcription Factor Targets	1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTHRP-(1-21)/PTH-(22-34) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
BRD-K77706833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30802
KDM5B	ENCODE Transcription Factor Targets	1.0	null
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MDA-MB-468	GDSC Cell Line Gene Expression Profiles	1.0	1.85356
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-188-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K69791255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17629
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0437484
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4427_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.17413
BRD-K25842662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44247
Age At Menarche	DisGeNET Gene-Phenotype Associations	1.0	null
RPLP0	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05561
LLC-PK1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.198
PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
DCUN1D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.54025
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.02993
Moderate Intellectual Disability	DisGeNET Gene-Disease Associations	1.0	null
BRD-K40018788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.157
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8846
JL1	CCLE Cell Line Gene CNV Profiles	1.0	1.56055
K-562	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1813
K562_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169775
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206484
[125I][NLE8,21,TYR34]PTH-(1-34)-NH2 (RAT)	DGIdb Drug Targets 2026	1.0	0.8822
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
parathyroid hormone receptor activity	GO Molecular Function Annotations 2015	1.0	null
K562_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237988
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A496-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GUCY1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632088
GTEX-S4UY-1226-SM-4AD51	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873757
PELP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00360001
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.880358
peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214765
K562_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271183
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43363
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K35240878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.55952
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.7105
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A10417568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25433
HDAC1	ENCODE Transcription Factor Targets	1.0	null
MX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10214
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9591
transgenic	GeneRIF Biological Term Annotations	1.0	null
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0304
Nucleus of the lateral lemniscus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50697
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934786
NCI-H510A	GDSC Cell Line Gene Expression Profiles	1.0	1.95741
BRD-K68202226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04387
cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0326-SM-32QOK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3822
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34735
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68377
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXB7-26014856-BT474-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6208
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88873
CTCF-21964334-BJAB-B-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230044
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548x	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9825
Hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.635
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02339
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Parathyroid carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
PTHLH	Guide to Pharmacology Protein Ligands of Receptors	1.0	null
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903266
SLC38A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00416519
RNF125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14727
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168959
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPCR, family 2-like	InterPro Predicted Protein Domain Annotations	1.0	null
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FUCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26567
CHD7	ENCODE Transcription Factor Targets	1.0	null
GTEX-S33H-1326-SM-4AD6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90421
TOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463504
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24946
Edema	CTD Gene-Disease Associations	1.0	1.22916
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186036
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64353
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190666
CRCGN011_HEPG2_24H:M05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26775
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05791
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.89489
when	GeneRIF Biological Term Annotations	1.0	null
Nephronophthisis 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90142
K562_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018585
ADAM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11634
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.41373
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.596862
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4509
BRD-K37544873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46304
colon_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
BRD-K87821938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30599
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09276
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10588
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061701
positive regulation of multicellular organismal process	GO Biological Process Annotations 2023	1.0	null
CBL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496802
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17242
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56532
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22802
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4957
brain	GTEx Tissue Gene Expression Profiles	1.0	0.834448
DHRS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68864
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83615
BRD-K57517066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05979
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
D425	DepMap CRISPR Gene Dependency	1.0	2.4046
CER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04528
BRD-K53988836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13757
CRCGN011_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09825
BRD-K78809123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23607
UMUC16	DepMap CRISPR Gene Dependency	1.0	11.648
Perturb_5711_KO_Dgcr8_SRP043436	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.5988
Spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.079
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10718
Lung squamous cell carcinoma_LUSC_TCGA-77-8009-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00905
TIMM8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55384
pyridoxine-1759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20477
Habenular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.215
KYO1	DepMap CRISPR Gene Dependency	1.0	3.50307
DUOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601648
SGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32608
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06005
RUNX2	ChEA Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A74Q-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03359
TAF1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DENND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0771
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38441
BRD-K78222058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05916
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.948228
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDRGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00456103
CUL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1404
BRD-K51843685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46779
Entorhinal area, medial part, dorsal zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75394
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fear	GeneRIF Biological Term Annotations	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
BRD-K89432538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79943
COV362	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.69672
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03594
BRD-A29371732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14673
BRD-K13564884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31564
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LB-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.931524
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.725685
RPUSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20603
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.7542
BRD-K14795621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20556
CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-7766-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071502
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3632
K562_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214431
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56844
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11477
pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.689492
[ILE5]PTHRP-(1-36)	DGIdb Drug Targets 2026	1.0	1.7644
fluvoxamine-2913	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10876822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11894
cerebellar nuclei of CbV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5798
K562_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0718191
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-7502-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09523238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80235
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3536
PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE85880,GSE85881_4_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247118
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41852
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0364619
PC14	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46054
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAS2R60	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057885
Signaling by GPCR	Reactome Pathways 2024	1.0	null
Thyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.761
CD58	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00456339
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.5338
embryoday7.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.21225
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20349
JAK2_druginhibition_168_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.08611
cortex of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50917
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54159
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.616586
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.901382
pancreas	HPA Tissue Protein Expression Profiles	1.0	1.66978
BRD-A20256229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38266
RPS6KA3	Hub Proteins Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Osteocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.337
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207795
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23821
ZNF143	ENCODE Transcription Factor Targets	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.825384
POLR2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04244
K562_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0315751
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.986326
tobramycin-2841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Frontonasal dysplasia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.902
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86521
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13036
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54265757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8239
BRD-K45076286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15825
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32941
LS411N	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04962
locus ceruleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.718703
Jansen's metaphyseal chondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.162
ISG15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16338
MAP3K21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31398
PTH	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0226-SM-2TF5E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85556
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873644
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
SNUPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727215
rodents	GeneRIF Biological Term Annotations	1.0	null
GTEX-WYVS-1726-SM-3NMAY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897884
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11477
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
brain	GeneRIF Biological Term Annotations	1.0	null
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01971
frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.143326
K562_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0311775
Brain_CT2_Amex 419	HuBMAP ASCT+B Annotations	1.0	null
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1929
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76422
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
olfactory tubercle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.990006
KIAA1958	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10464
BRD-K06997715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42131
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.379997
NCIH82	DepMap CRISPR Gene Dependency	1.0	2.09324
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
UMR-106 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.268
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16561
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10916124-12864_2024_10174_MOESM1_ESM.xlsx-Supplementary_Table_6-The_downstream_genes_targeted_by_FLI1_The_ligand_vs_receptor_pairs_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CRLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81708
r3 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05092
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51807
Nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59178
positive regulation of metabolic process	GO Biological Process Annotations 2025	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30852
DGKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055028
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28438
K562_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219718
ZGLP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605499
Nucleus of the lateral lemniscus, horizontal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03303
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8114
Periventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.575
COL16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62378
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MORN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.581
Lung squamous cell carcinoma_LUSC_TCGA-34-5929-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKACB	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K84062787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16527
median eminence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.701489
Optic lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
Lobule II	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03493
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17107214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60546
distribution	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
positive regulation of multicellular organismal process	GO Biological Process Annotations 2025	1.0	null
K562_YM155_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159397
BRD-K29466595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06224
K562_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0338524
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210961
L428	CCLE Cell Line Gene CNV Profiles	1.0	1.40398
interneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307167
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-Unnamed_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85475457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26177
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
distinct	GeneRIF Biological Term Annotations	1.0	null
Osteoporosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
TSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17382
BRD-K99412981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48171
Posterior amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
oxantel-1277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ERG_01_216	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59498
acquisition	GeneRIF Biological Term Annotations	1.0	null
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.987767
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.031415
hsa-miR-4776-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PRDM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26183
BTBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13756
BRD-K69389910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61987
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5064
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
CBX2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.223926
QGP1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.1678
GTEX-WRHU-0326-SM-3MJFY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24653
BRD-K44643967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79654
GPCR downstream signaling	Reactome Pathways 2014	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05999
increased heart weight	MGI Mouse Phenotype Associations 2023	1.0	null
inferior frontal gyrus, opercular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.918011
periventricular stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63977
CBX2	ENCODE Transcription Factor Targets	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.685551
BRD-K10011427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43958
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57321
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33164
bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049005
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829465
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cyclosporin A_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0212076
FOXM1-26456572-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Unnamed_0_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MANBAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26918
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6126
BRD-K83300227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02043
BRD-K26195700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09905
heart muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.84442
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.42499
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9062
superficial stratum of r1BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17896
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of isLim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34649
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A641-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPCRs, Class B Secretin-like(Mus musculus)	WikiPathways Pathways 2014	1.0	null
BRD-K40367360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10921
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0660332
CRCGN012_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0609
SERPINB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19324
post-traumatic stress disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
PHF8	ENCODE Transcription Factor Targets	1.0	null
MAPK1_knockdown_112_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.43007
LCLC-103H	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67292
BRD-K92172862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34991
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4444
PCGF2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-539	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
KNS-62	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COV318	CCLE Cell Line Gene CNV Profiles	1.0	1.51112
BRD-A04231641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29304
r9 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4054
ME1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.10417
GSE169617_1_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12735
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4852_KD_ZNF503_SRP059197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.46226
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79735667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17595
NCIH2227	CCLE Cell Line Gene CNV Profiles	1.0	2.46187
NMRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01054
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21664
MED24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30333
CAMSAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07204
KYSE510	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01137
Intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
BRD-K37634338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96185
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870108
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62302
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A78125048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36116
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	1.0	null
layer 2 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3625
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
APOE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00364846
GTEX-NPJ8-0011-R4a-SM-2HML3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03979
mice	GeneRIF Biological Term Annotations	1.0	null
CHK1_KD_GSE54268_666_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8239
GSE198165,GSE198166_6_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basolateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.968574
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ANTXR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692829
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11321
KNS-81-FD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K52414345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95914
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.63796
BRD-K94196749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14239
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIG-M5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29994
K562_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0266549
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-342-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
USP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39637
BRD-K88447092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06387
MEL-JUSO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.886784
Ventilator-associated lung injury_Lung Tissue_GSE2411	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.14625
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250175
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850449
ZC3H11A_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6956-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07565511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22076
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
BRD-K31187110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43138
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3187
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56021
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15592
CHK2_KD_GSE54268_667_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Rheaume et al.Nat Commun.32_Retina_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00886
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08335
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K58865204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61953
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0526-SM-4B65N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18264
hsa-miR-371-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ERI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05667
BMPR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71505
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PTHRP-(1-36)	DGIdb Drug Targets 2026	1.0	0.8822
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BL-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06324
PCGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582767
BRD-K30491662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33713
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14012
SKMEL5	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.97804
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45022
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29371
SLC39A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42142
SPHK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536941
Inner chondrogenic layer of perichondrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.567
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4541
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238389
BRD-K20016759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46149
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057175
BRD-K65633211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08104
superficial stratum of Ist	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19031
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0309844
Corpus albicans	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.24
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57878
Hexylresorcinol_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0171856
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	1.0	2.17388
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GBA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644788
BRD-K82446079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19319
SKN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38231
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.461
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K22701871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00967
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0252
HMV-II	GDSC Cell Line Gene Expression Profiles	-1.0	-2.13805
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA2	ChEA Transcription Factor Targets	1.0	null
plate	GeneRIF Biological Term Annotations	1.0	null
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02368
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
K562_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225626
FAAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20576
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.858333
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05067
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Bexarotene_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0241101
BRD-K82364958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50851
H3K27me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57830670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10998
Hailey-Hailey disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
WARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03859
BRD-K32881384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05591
NCI-H1623	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554655
Oxaprozin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0258959
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62878
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224457
hsa-miR-4659a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K39159284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33404
Central lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06298
TMEM39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13215
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
(+)-chelidonine-1786	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148804
NANOG	ChEA Transcription Factor Targets	1.0	null
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45029
SUZ12	ENCODE Transcription Factor Targets	1.0	null
Rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25129
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bergenin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268803
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144261
BRD-K61354849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99736
Preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.75
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16925
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A23V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.004246
OC315	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59617
ALAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00891
Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32386
CDK5RAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71417
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.89446
locations	GeneRIF Biological Term Annotations	1.0	null
DSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24388
periventricular stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18275
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.430845
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
intermediate stratum of m1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8768
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.2088
BRD-K72580121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12335
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.0954
Ventral striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sildenafil_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0181796
GTEX-R53T-1526-SM-48FEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91604
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999348
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828938
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46702
K562_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303298
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903266
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0346857
CPT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548867
Auditory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
BRD-K75130046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02905
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07234
GOLGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82395
OK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.383
Signal Transduction	Reactome Pathways 2014	1.0	null
BRD-K78397696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10466
K562_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286399
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08039
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.55549
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2544
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
specific	GeneRIF Biological Term Annotations	1.0	null
CTCF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04998
properties	GeneRIF Biological Term Annotations	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0334678
Mouse - Motor Cortex - Cluster - Pvalb+ Gabrg1+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73656
BRD-K16911140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72565
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TE14	CCLE Cell Line Gene Expression Profiles	1.0	1.41108
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25438
Purkinje cell layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48301
Gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RMUGS	DepMap CRISPR Gene Dependency	1.0	3.61947
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04777
PrPC_KO_GDS4352_358_mouse_Developing hippocampus from FVB newborns (4.5-day-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BL2764 (HNRNPU)	NURSA Protein Complexes	1.0	null
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87080069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46692
Heart endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.446
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medial amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.779
binding	GO Molecular Function Annotations 2015	1.0	null
SUM149PT	DepMap CRISPR Gene Dependency	1.0	3.96181
BRD-K08715020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5543
accommodate	GeneRIF Biological Term Annotations	1.0	null
K562_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0559303
[TRP23,TYR36]PTHRP-(1-36)-NH2 (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
BRD-K76966915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37072
ZNF317	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52852
RPS6KA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61451
BOLA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05357
GRWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41109
CTNNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45041
lateral terminal nucleus of the accessory optic tract, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63528
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.506672
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61407677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28479
MCAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ETV1-20927104-GIST48-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4644-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HEC6	DepMap CRISPR Gene Dependency	1.0	4.8807
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.351382
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194009
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RASD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54341
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.603
NCIH211	CCLE Cell Line Gene CNV Profiles	1.0	2.19269
layer 1 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09177
MECOM_KO_GDS3343_554_mouse_Hematopoietic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
interactions	GeneRIF Biological Term Annotations	1.0	null
SIRT1_KO_GDS4895_410_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855207
Circumventricular organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.465
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.037888
G protein-coupled receptor heterodimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.978
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175023
ESRRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00396238
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.930628
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0407204
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
PANC0504	CCLE Cell Line Gene Expression Profiles	-1.0	-2.10275
BRD-K93126086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35291
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0349709
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Parasubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36301
tip39	GeneRIF Biological Term Annotations	1.0	null
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243273
TCFL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57005
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-AB2J-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178067
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5896
GPI-PLD_OE_GDS2049_176_human_Hepatoma HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2318
kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.129563
DDX56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31996
GTEX-UPIC-1126-SM-4IHLO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.69407
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291287
C9orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66567
CBX8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217022
BRD-A68797623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0287
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.55022
Ischemic bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
K562_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190184
GAPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5108
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colon	HPA Tissue Protein Expression Profiles	1.0	0.877505
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.8244
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.964354
Myosin IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
BRD-K98625375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24393
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24625
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0408017
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28538
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18735
[TRP23]PTHRP-(1-36) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87815
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74676765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34486
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1937	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AP2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39062
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
SKN3	DepMap CRISPR Gene Dependency	1.0	2.03241
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02339
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.6528
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPK5-0426-SM-3GAEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13719
NCI-H1092	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834918
Uvula (IX)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6005
hsa-miR-323-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Superior colliculus, sensory related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16285
periventricular stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02161
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18079
cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.476831
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JAK1_druginhibition_166_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.08611
hyperparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.212608
Acute Myeloid Leukemia_LAML_TCGA-AB-2814-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal depression-related behavior	MGI Mouse Phenotype Associations 2023	1.0	null
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.97077
Prostate adenocarcinoma_PRAD_TCGA-EJ-5519-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
[Ile<sup>5</sup> Trp<sup>23</sup> Tyr<sup>36</sup>]PTHrP-(1-36)-NH<sub>2</sub> (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K95792127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10672
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28141
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7398-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43435656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11364
PCGF4-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
[Ile<sup>5</sup> Trp<sup>23</sup>]PTHrP-(5-36) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
K562_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172667
Osteomalacia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
BRD-K32269272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11324
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6142
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60063
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0362
BRD-K61753872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93001
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38525
K562_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330844
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835288
Dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZF-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.899228
K562_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167191
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262306
PNU-0230031-4757	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Degenerative Polyarthritis	DisGeNET Gene-Disease Associations	1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	3.38363
BRD-K65503129_CCT 018159_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.47448
angular gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.878786
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SA-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
grl101	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
Nucleus of the brachium of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67741
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HLA-DPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604318
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Imiquimod (maleate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0236626
positive regulation of cold-induced thermogenesis	GO Biological Process Annotations 2025	1.0	null
Sexine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
Prostate adenocarcinoma_PRAD_TCGA-G9-6378-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	3.94791
into	GeneRIF Biological Term Annotations	1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.206
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01669
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59283
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.82355
CTCF	ChEA Transcription Factor Targets	1.0	null
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09083
K562_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139788
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180602
Lung squamous cell carcinoma_LUSC_TCGA-77-7140-01A-41R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65183353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10936
SPAST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.86996
BRD-K97343426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03351
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218874
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K31204557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75676
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.65689
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5882
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75407
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-548am	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K95153427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43779
K562_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175706
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01587
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.981084
mantle zone of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0898
Craniosynostosis	DisGeNET Gene-Disease Associations	1.0	null
Sarcoma_SARC_TCGA-DX-A6B9-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180408
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28018
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
12687021-Table2	GeneSigDB Published Gene Signatures	1.0	null
layer 3 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66489
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199339
superficial stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51063
Rubrospinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.371
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01066
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67299
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.351002
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAPOLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6044
ADK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522518
Infundibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Roxadustat_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0202872
CMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
G protein-coupled peptide receptor activity	GO Molecular Function Annotations 2025	1.0	null
H3K27me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HEKTE	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0687
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017181
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932222
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1882
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31407
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65257143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67629
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0635772
RPS6KA3	KEA Substrates of Kinases	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0626-SM-48TYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01234
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87485
Dorsal raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67107
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chondrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.591
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34082
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4IJ-01A-31R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.790212
PU-27001747-CHIP-SEQ-BMDM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SIRT1_Deficiency_GDS4895_316_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.940241
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02213
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71V-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07034
BRD-K94833531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01913
NOMO1	DepMap CRISPR Gene Dependency	1.0	3.45963
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05809
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11638
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72337
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ANKRD28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31679
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.439119
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tubulin inhibitor 6_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0198235
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Infralimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.285
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212146
Central amygdalar nucleus, capsular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16434
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46215
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3916	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CRCGN015_MCF10A.TP53.M_24H:M18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01825
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22058
BRD-K23868551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3657
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.385051
NCI-H345	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Matrilin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.114
CDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29072
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12278
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypercalcemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.848
LXF-289	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Retina	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
decreased grooming behavior	MGI Mouse Phenotype Associations 2023	1.0	null
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.47206
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7017
Weight Loss	CTD Gene-Disease Associations	1.0	1.22566
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.610943
GSE152246_0_v_1_dihydrotestosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus preopticus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.72
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.838072
occipito-temporal gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.834023
hsa-miR-4712-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2037
Anastrozole_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260107
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCC-MF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
[D-TRP12,TYR34]PTH-(7-34) (BOVINE)	DGIdb Drug Targets 2026	1.0	0.8822
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
CRCGN014_HEPG2_3H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28475
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Decitabine_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0194424
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24224
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052198
methazolamide-2733	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thiostrepton-2462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUZ12-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47425
central amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.696989
NFE2-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SLC1A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30756
Raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0697328
MHHNB11	DepMap CRISPR Gene Dependency	1.0	3.03348
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8808
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20F-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDQP1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24638
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.611346
D423MG	DepMap CRISPR Gene Dependency	1.0	5.91545
Medial geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941571
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834918
Anterior hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.323
Mitotic cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28431
TAF1	ENCODE Transcription Factor Targets	1.0	null
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
K562_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.039101
GSTO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04302
GTEX-RN64-1626-SM-48FD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25595
Metabolic disorders of biological oxidation enzymes	Reactome Pathways 2014	1.0	null
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.328
MEK_OE_GDS1925_165_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K80877725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61278
NKX2-6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559143
EHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.015
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-107	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05776
OGFOD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577636
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28122619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10874
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FCGRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16318
GIMEN	DepMap CRISPR Gene Dependency	1.0	2.86631
BRD-K62547690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40212
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.14598
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3754
SLR23	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67552
PAQR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16319
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07271
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5768_KO_Sip1/Nkx21_SRP010804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.9277
ventral part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0619
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9384
AGS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB5	GDSC Cell Line Gene Expression Profiles	1.0	1.97074
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A6MB-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222652
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.946095
IMR32	DepMap CRISPR Gene Dependency	1.0	2.9805
18537972-TableS3	GeneSigDB Published Gene Signatures	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.6665
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.10098
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TT-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46751
reproductive	GeneRIF Biological Term Annotations	1.0	null
TMC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778977
Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DU4475	DepMap CRISPR Gene Dependency	1.0	8.9569
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53527
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.661
Pseudohypoparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
hsa-miR-4705	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
residue	GeneRIF Biological Term Annotations	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95675
BRD-K13817284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06515
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.963
Isolated growth hormone deficiency type IB	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.779
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.44443
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
nefopam-2355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RDH11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395971
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.911806
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-e-Classification_of_camel_SON_basal_genes_-_G_protein_coupled_receptors_SON	Rummagene Transcription Factor Associations 2026	1.0	null
CALM1	Hub Proteins Protein-Protein Interactions	1.0	null
Integrin alpha10-beta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
avian pallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.829034
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223419
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
caudate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.264011
BRD-K30433551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09623
BRD-K88282877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08643
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perihypoglossal nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59353
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93854
MYCN_01_160	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.50159
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94109423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73163
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60059
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Epithalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
RCM1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.11876
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03184
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YY2_KD_GDS3788_490_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66649343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63621
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04197
G protein-coupled receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.502
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ALPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484404
BRD-K16093370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69077
HAGHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48327
CNEP1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6736
LCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40299
BL2296 (EDC4)	NURSA Protein Complexes	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2813-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BAZ1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489184
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	6.11144
PRKAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558851
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Motor trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
Relugolix_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245365
Thyroid cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.314
MOLM16	CCLE Cell Line Gene Expression Profiles	1.0	1.94663
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7862
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCC2935	DepMap CRISPR Gene Dependency	1.0	2.21824
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922295
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18003
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51906
BRD-K55884477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07308
Lateral habenular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.535
abnormal locomotor behavior	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K03549232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.55712
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6721
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ventromedial hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Penfluridol_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0428415
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21	ChEA Transcription Factor Targets	1.0	null
K562_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210987
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293734
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.86826
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50065
BRD-K39534157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41417
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.8748
BRD-K73969016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43839
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-562	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
RCOR1	ENCODE Transcription Factor Targets	1.0	null
17597811-SuppTable5	GeneSigDB Published Gene Signatures	1.0	null
BRD-K28467941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67745
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18395
Laryngeal cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.261
K562_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220653
Sarcoma_SARC_TCGA-Z4-A9VC-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.275444
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.00055
BRD-K98935620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24845
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239049
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844449
PDCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054362
extracellular matrix part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049697
BCP1	CCLE Cell Line Gene CNV Profiles	1.0	1.57647
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076164
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PCGF2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
fibers	GeneRIF Biological Term Annotations	1.0	null
BRD-K64732418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81252
osteochondrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.06942
Secondary hyperparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.526
BRD-K07361992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11715
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0368
TCF12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76910883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18351
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180265
regulate	GeneRIF Biological Term Annotations	1.0	null
Familial gestational hyperthyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
superior occipital gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888101
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.044682
GCT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8086
K562_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0356098
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0833831
layer 3 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27428
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HENMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39744
BRD-K37592272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39714
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63789
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary hyperparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.778
outer CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868915
norepinephrine	GeneRIF Biological Term Annotations	1.0	null
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63839
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Gene_Name_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22045035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29272
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78273
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.08439
KLF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78611
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VK-01A-21R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superior temporal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.895232
periventricular stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21555
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.039856
[ILE5,TRP23]PTHRP-(3-36) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
K562_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0406713
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.949318
SMC1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.830127
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78P-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G alpha (s) signalling events	Reactome Pathways 2014	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4712
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20368
DPPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67047
Fibre tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.976
KMCH1	DepMap CRISPR Gene Dependency	1.0	2.3775
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02996
ZWINT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71003
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08005
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840071
MTMR12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11554
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
Prostate adenocarcinoma_PRAD_TCGA-EJ-5521-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00955
BRD-K79521948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05347
BRD-K17910820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3003
K562_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0321233
SETDB1	ChEA Transcription Factor Targets	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26078
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DEDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31078
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.933932
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829465
Vinblastine (sulfate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240587
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7015
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11688
BRD-K93295557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7785
heart	GeneRIF Biological Term Annotations	1.0	null
BRD-K44652223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2674
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19074
hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.322779
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4528	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0499927
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13202
TIP39-(7-39) (human/bovine)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
NMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
phe	GeneRIF Biological Term Annotations	1.0	null
BRD-K51342021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93689
PTHrP-(7-34) (human  rat  mouse)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
posteroventral (inferior) parietal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.122
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159616
superior parietal lobule, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1283
Locus ceruleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.421
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
[Ile<sup>5</sup> Trp<sup>23</sup>]PTHrP-(2-36) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00137579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17281
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K00231307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3896
NCIH2171	Achilles Cell Line Gene Essentiality Profiles	1.0	1.33653
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.14797
GTEX-UJHI-1426-SM-3DB9C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19101
K562_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025029
Subiculum, ventral part, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10869
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29444
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28456
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92927161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15602
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paragigantocellular reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34142
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
either	GeneRIF Biological Term Annotations	1.0	null
UACC257	DepMap CRISPR Gene Dependency	1.0	2.16532
abnormal behavior	MGI Mouse Phenotype Associations 2023	1.0	null
DPY-21335234-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Superior colliculus, superficial gray layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18225
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXD3_02_83	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61334
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6114
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.385051
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87954
intermediate stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17606
BRD-K66807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63023
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28456
GTEX-XOT4-0008-SM-4B664	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892314
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K58743752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23278
Generalized Osteoarthritis	DisGeNET Gene-Disease Associations	1.0	null
K562_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256408
GTEX-VUSG-2726-SM-4KKZJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01294
K562_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170161
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4677-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
POLR3F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25646
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0352272
BRD-K10505056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52926
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MC-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CUTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00453
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	4.02397
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.40328
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.7708
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42686
LSM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26695
BRD-A19615705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30243
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06561
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.64845
PHYH	Pathway Commons Protein-Protein Interactions	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.86347
KCNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597801
Lung adenocarcinoma_LUAD_TCGA-55-7995-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13859368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02382
DICER1_KO_GDS4504_583_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
IDI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497741
K562_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.039389
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8575
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36031198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09317
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3BZ-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181065
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01078
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0365429
KYSE-270	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1398
PATU8988T	DepMap CRISPR Gene Dependency	1.0	2.04467
Endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
K562_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0335972
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
position	GeneRIF Biological Term Annotations	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831208
BRD-K10178088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34147
BRD-K07662722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28565
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Precommissural nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81339
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKCB	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K77519898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03116
CBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31877
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PD-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44Q-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4727-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Osteochondrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
r7 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2321
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11226
Central amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.813
TBP	ENCODE Transcription Factor Targets	1.0	null
HCC1806	CCLE Cell Line Gene Expression Profiles	1.0	1.97612
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21189
POLQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3396
pthlh	GeneRIF Biological Term Annotations	1.0	null
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intercalated amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42155
IFIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15877
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
CCNK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42244
SIRT4_KO_GDS4823_30_mouse_hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-M34385771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97419
IKBIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601505
BRD-K59120074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43147
BLVRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23234
SPART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71784
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4388
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719051
K562_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236913
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.896959
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4382-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Abnormality Of Pain Sensation	DisGeNET Gene-Phenotype Associations	1.0	null
K562_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263964
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.683486
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46778
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0339766
H3K27me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90217
CD80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542877
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22524
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
PEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43654
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00477
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62435
Cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.728
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12819
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A894-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0011-R10A-SM-4AT4A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970835
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8321
Osteitis fibrosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088392
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8185471-mmc6.xlsx-up-_and_downregulated_genes-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_shared_FO_and_FC_regions_respectively_Related_to_Figure_6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-EGR2-Symbol_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6027-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT1_KO_GSE28790_47_mouse_brain (3 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aminophylline-3374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ractopamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62432
BRD-K54233340_Dorsomorphin dihydrochloride_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227434
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25295
ChIP_H3K27me3_18600261_mouseWholeBrain	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6814
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26036
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885459
mediate	GeneRIF Biological Term Annotations	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983754
TERIPARATIDE	DGIdb Drug Targets 2026	1.0	0.588133
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17738
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ES-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTHRP-(1-34) (HUMAN)	DGIdb Drug Targets 2026	1.0	1.7644
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-1926-SM-4DXSG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48147
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63874
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IX-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58469385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30435
inferior frontal gyrus, triangular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09926
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.0983
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15052
BRD-K12107215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08343
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.933032
CGTHW1	CCLE Cell Line Gene Expression Profiles	1.0	1.45484
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61156
snps	GeneRIF Biological Term Annotations	1.0	null
CACHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480804
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
RPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87616
stroke	GWASdb SNP-Phenotype Associations	1.0	0.488666
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRAK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620632
PMC8616957-41467_2021_27270_MOESM4_ESM.xlsx-Sheet1-Supplementary_Data_1_Differentially_expressed_genes_FDR_0_05_edgeR_exact_test_in_MLL-AF4_infant-ALL_vs_MLL-AF4_childhood-ALL_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
LDLRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13211
pth	GeneRIF Biological Term Annotations	1.0	null
BRD-K48069820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01428
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857239
MAP3K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629132
FOXO1_KD_GDS2720_477_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K05357297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13506
IL5RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00473905
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72959
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51942
neurohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.599675
Amylin receptor complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.017
SETDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51794
UQCR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57224
GTEX-X5EB-1726-SM-4E3J7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96295
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982416
K562_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192425
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0346385
RERFLCAI	CCLE Cell Line Gene CNV Profiles	1.0	1.67496
[Trp<sup>23</sup> Tyr<sup>36</sup>]PTHrP-(1-36)-NH<sub>2</sub> (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51368
BRD-K30795375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63851
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K62182950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74216
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0366651
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907661
BRD-K92613860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32525
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71622
BRD-A03898562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22425
Frontonasal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76376
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3476
NRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66308
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13404
hsa-miR-802	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
JAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00453699
Cerebral peduncle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2009	GDSC Cell Line Gene Expression Profiles	1.0	1.9436
WDR45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38766
CABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38815
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88188
icSARS CoV_24Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.39603
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EN-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL-39	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K04559718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06374
SIDT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654265
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151144
H3K27me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0308078
COV318	CCLE Cell Line Gene Expression Profiles	1.0	1.78351
ZNF302	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24739
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47489
Nucleus preopticus medianus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
VWA5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35859
chlorpromazine-1864	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08634
CBX8	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vascular disease	GWASdb SNP-Disease Associations	1.0	0.120409
BRD-A08363225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92058
ZNF281	ChEA Transcription Factor Targets	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6651
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897624
SPEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51311
thyroid gland	HPA Tissue Gene Expression Profiles	-1.0	-1.26798
IGF1R_knockout_151_GSE32936	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	4.03911
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43864
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16577
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7370-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830392
BRD-K70254692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14882
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181786
precuneus, left, inferior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.913194
SEH1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6626
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.019
OVKATE	CCLE Cell Line Gene Expression Profiles	1.0	1.79536
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29613
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A6QX-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-6842-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221257
hsa-miR-877	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Entorhinal area, medial part, dorsal zone, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52949
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9864
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.19955
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZIC3	ChEA Transcription Factor Targets	1.0	null
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22826
alcuronium chloride-4409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90065
SET2	CCLE Cell Line Gene Expression Profiles	1.0	1.68588
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-1126-SM-4LMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839215
HEPG2	CCLE Cell Line Gene CNV Profiles	1.0	1.41739
Aprepitant_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0246512
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09018
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.080878
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ADAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69398
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.84442
LCLC-97TM1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48867
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
consequences	GeneRIF Biological Term Annotations	1.0	null
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14051
Superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38215
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10538
Skin tag	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.10354
Metaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.878
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277752
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.237216
BRD-K81619018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03097
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SCA1_Knock-in_GDS3544_562_mouse_Cerebellum - 12 Weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1229
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0062
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3897
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900724
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.88543
reticular formation of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7028
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0522
regulation of cold-induced thermogenesis	GO Biological Process Annotations 2023	1.0	null
RB1_KD_GSE50532_641_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RFXAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534299
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31497
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96642
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.21955
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.37826
Signaling by GPCR	Reactome Pathways 2014	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_114_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
culture medium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.435672
K562_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0410611
PMC2742312-1479-7364-3-3-221-S3.PDF-64-ALS2CR8_CARF	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HQ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99564685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21833
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.97077
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229658
JPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21551
hsa-miR-603	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5877-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hsa-miR-3941	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ventrolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.904883
posterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56667
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24574
K562_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193638
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
K562_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025243
URB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065127
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	0.932012
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.933792
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25992
HSC-39	COSMIC Cell Line Gene Mutation Profiles	1.0	null
responses	GeneRIF Biological Term Annotations	1.0	null
K562_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.038474
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K20278539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77316
SMARCA4	ChEA Transcription Factor Targets	1.0	null
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS-299	GDSC Cell Line Gene Expression Profiles	-1.0	-2.07489
BRD-K94790210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2314
LJI308_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0147011
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06747
Olfactory tubercle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
abnormality of brain morphology	GWASdb SNP-Phenotype Associations	1.0	0.120877
MCM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40915
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0386535
DHRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45432
MTHFSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04872
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70471
GTEX-T2IS-1526-SM-32QPR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90622
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.661116
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TCF4-32651957-PLC/PRF/5-HUMAN-LIVER-HEPTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K17152303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23801
ALL-PO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0323781
CHD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608069
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7578
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21615
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01163
BRD-K38084509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31739
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02339
Cortical amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.47
IFNA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00690378
CTHRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50821
Retrohippocampal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12592
GSE202434,GSE202438_2_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.984571
lymecycline-2953	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
BRD-K17743313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26832
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11103
RPS6KA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00483862
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.831457
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34636
Amyotrophic lateral sclerosis (sporadic)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SFPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16728
BRD-K64860662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40206
ATP5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03247
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37745
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WI4N-1426-SM-3LK7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00414
BRD-K05939258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36356
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21022
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K27me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
native	GeneRIF Biological Term Annotations	1.0	null
BRD-K47001624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35504
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.223853
Hyperparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.978
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Vitamin K4_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231548
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03094
CTCF	ENCODE Transcription Factor Targets	1.0	null
EMX2_Deficiency_GDS3173_607_mouse_Embryonic urogenital epithelium - day 10.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
mouse	GeneRIF Biological Term Annotations	1.0	null
COS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.451
K562_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232607
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88188
GPCRs, Other(Mus musculus)	WikiPathways Pathways 2014	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4989
PPARD	ChEA Transcription Factor Targets	1.0	null
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894366
K562_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369063
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.776909
BRD-K34974135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83406
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.93515
MAGED4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17571
K562_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228243
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
K562_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224221
RAD21_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
mass	GeneRIF Biological Term Annotations	1.0	null
BRD-K69594935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.82253
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-2q37_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05474024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64023
Fatty Liver	CTD Gene-Disease Associations	1.0	1.03308
GSE89154_1_v_2_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr2_208372902_T_C_b38	GTEx eQTL 2025	1.0	4.07912
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8467
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
PRSS22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95192
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Vestibular nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10465
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174851
butyrylcholine-cl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52097
Medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03886
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831208
CLDND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20334
hsa-miR-2116	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
ZNF256	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60856
r1 part of intermediate nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17811
FLI1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DE-01A-22R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
[D-TRP12]PTH-(7-34) (BOVINE)	DGIdb Drug Targets 2026	1.0	1.7644
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5858
K562_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188782
F5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.82107
CRCGN010_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03479
MHHES1	CCLE Cell Line Gene CNV Profiles	1.0	1.38618
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10590495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00235
ARID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53849
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.45456
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944028
physiological	GeneRIF Biological Term Annotations	1.0	null
Hypercalcemia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K96295480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61307
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.8697
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7837
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUP-B15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
[ILE5,TRP23]PTHRP-(5-36) (HUMAN)	DGIdb Drug Targets 2026	1.0	1.7644
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166006
CRCGN015_HEPG2_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04003
BRD-A95239561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48485
K562_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154199
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6349
lycorine-2195	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lumbar spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
Substantia innominata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226411
hsa-miR-4477a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K92748025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50525
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00276
GPCR ligand binding	Reactome Pathways 2024	1.0	null
MVK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37213
Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
paralemniscal isthmic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29305
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47694
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15935
Supplemental somatosensory area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15975
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.55182
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18224
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.6295
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K80880605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54459
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.404039
hsa-miR-3166	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW948	CCLE Cell Line Gene CNV Profiles	1.0	1.42642
CREB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61872
SOX7_OE_GDS3300_123_human_HESC (CA1 and CA2)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
IZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.927629
Fostamatinib (disodium hexahydrate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.021647
chondrocytes	GeneRIF Biological Term Annotations	1.0	null
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03377
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeleton	GeneRIF Biological Term Annotations	1.0	null
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016052
Adrenomedullin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.602
Laterodorsal thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197212
primates	GeneRIF Biological Term Annotations	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT55	DepMap CRISPR Gene Dependency	1.0	3.60576
K562_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0509398
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.933032
STRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35223
osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.158778
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.7785
BRD-K77935284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36861
BRD-K37616496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56832
BRD-K15980298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02313
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5469
cell part	GO Cellular Component Annotations 2015	1.0	null
fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.989335
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20982
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06867
ioxaglic acid-2966	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957791
Prostate adenocarcinoma_PRAD_TCGA-H9-7775-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26876
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191
ZFP281-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919528
CHP126	CCLE Cell Line Gene CNV Profiles	1.0	2.10516
Lung squamous cell carcinoma_LUSC_TCGA-52-7809-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26659
K562_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026361
GTEX-S4UY-0726-SM-4AD6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01917
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Salicylic acid_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222335
hsa-miR-4690-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
bone	GeneRIF Biological Term Annotations	1.0	null
BRD-K63887881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.67657
ZNF217-24962896-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
f11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
K562	BioGPS Cell Line Gene Expression Profiles	1.0	0.883627
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BL3967 (USP3)	NURSA Protein Complexes	1.0	null
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12473
NCIH2009	CCLE Cell Line Gene Expression Profiles	1.0	2.14719
Columella	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
BRD-K57251296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49953
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32177
Brain_CT2_Thex 372	HuBMAP ASCT+B Annotations	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypb_Deficiency_GDS3641_523_mouse_Yolk sac from E10.5 embryos	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0611493
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.281
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49344
intermediate stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20015
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44736
8305C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Tegmentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.515
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24371
Craniosynostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24371
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.861186
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28094
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14605
Neural lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
GTEX-XGQ4-2626-SM-4AT6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54458
GSE189653,GSE203344_2_v_0_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152454
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0745
Idiosyncratic drug effect_Hepatic Tissue_GSE2825	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.60385
BRD-K87920761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38898
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57797
BRD-K76984291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40041
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64234
DVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11516
ARID3A	ENCODE Transcription Factor Targets	1.0	null
MDAMB468	CCLE Cell Line Gene Expression Profiles	1.0	1.6159
ZNF391	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00835086
OVCAR8	CCLE Cell Line Gene CNV Profiles	-1.0	-2.27489
Prostate adenocarcinoma_PRAD_TCGA-EJ-5507-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-AAVH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50008138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05391
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13064
diprophylline-1853	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DMRTA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3961
PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999348
NSUN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26386
K562_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0387341
INSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.63333
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE195743_3_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone development disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8061
Non-odorant GPCRs(Mus musculus)	WikiPathways Pathways 2014	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5657
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.459145
K562_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182679
C2BBE1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K47854067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53683
Paraventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.662
Lung squamous cell carcinoma_LUSC_TCGA-56-7582-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHACTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645733
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928786
Bladder Urothelial Carcinoma_BLCA_TCGA-S5-AA26-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.9414
KYSE-510	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.450271
ZNF217	ChEA Transcription Factor Targets	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7677
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192202
OPRL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522348
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ER_ZNF_GATA3-Nearest_Ensembl_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21678546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22921
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887269
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
K562_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0610119
Elagolix sodium_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162296
MYOC_OE_GDS1640_269_mouse_retina	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
COX6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02392
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26305
COS-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.442
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
CORL88	CCLE Cell Line Gene Expression Profiles	1.0	1.60558
KNS60	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.50734
NCI-H1693	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548469
G402	CCLE Cell Line Gene CNV Profiles	1.0	1.68691
K562_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254836
hip	GAD Gene-Disease Associations	1.0	null
Bed nucleus of stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pthr2	GeneRIF Biological Term Annotations	1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862628
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872023
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62386
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
artery disease	GWASdb SNP-Disease Associations	1.0	0.16406
FOSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005861
CCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09141
PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Unnamed_3_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
TNFRSF21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00340039
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041557
K562_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171089
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17823238-TableS5	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebral gray matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.701489
K562_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286931
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-2426-SM-48FF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87228
LRPPRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13046
SNU-449	GDSC Cell Line Gene Expression Profiles	1.0	1.42334
BRD-K84199148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24077
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58832
PRKACB	KEA Substrates of Kinases	1.0	null
MCCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26925
cdx2_20696899_caco2_lof_human_gpl570_gse22572	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.67343
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185703
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
External cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05411
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0434143
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0282827
pituitary	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
pthr1	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-1026-SM-46MUR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12358
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parathyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.053
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91060460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01136
KCTD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24553
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-1926-SM-4BOOV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15534
K562_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224628
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5505
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.08512
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18539
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829465
K562_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0399002
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
Ouabain (Octahydrate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0197513
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney	GeneRIF Biological Term Annotations	1.0	null
BRD-K42671829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30971
Lung squamous cell carcinoma_LUSC_TCGA-34-5231-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41Q-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
BRD-K89230185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61941
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22994
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYK_knockdown_279_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.67976
Cerebellar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52722
BRD-K60839995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71798
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bimolecular	GeneRIF Biological Term Annotations	1.0	null
RPH3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48985
Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Suicide Attempt	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K37637965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59992
BRD-A05422420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17038
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5735
cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57321
hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.23182
Cholestasis	CTD Gene-Disease Associations	1.0	1.17168
BRD-K04969760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21027
superficial stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03795
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
VAV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00714263
KYSE-220	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07451
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.248216
endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068269
SNU478	DepMap CRISPR Gene Dependency	1.0	2.45458
TIG3TD	CCLE Cell Line Gene Expression Profiles	-1.0	-2.91587
Digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Phosphorus metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.29534
K562_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185099
GAPVD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42448
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.98131
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46778
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18192
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.726
K562_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181105
SUZ12	ChEA Transcription Factor Targets	1.0	null
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00953
Bortezomib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.012837
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IMR-5	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56761
Sarcoma_SARC_TCGA-IF-A3RQ-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14383477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15532
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29492
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3236
FOXP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90057
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260689
GSE103003_1_v_0_zeb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46031
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238311
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215429
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.7621
Psoriasis vulgaris_Skin tissue_GSE14905	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.62029
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
[Ile<sup>5</sup>]PTHrP-(1-36)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
SOX11-22085726-ESNS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
PPARA_agonist activation_GSE17250_475_mouse_Isolated hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-3154	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.97823
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.887981
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167712
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2314
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46778
GSE195559_0_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05002
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Lacquer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
postactivation	GeneRIF Biological Term Annotations	1.0	null
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00338
KLF2_01_226	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.64462
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PRKAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61714
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22046
GTEX-S4Z8-0126-SM-4GICC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850161
K562_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274882
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
olfactory tubercle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16683
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.930595
NFI-21473784-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237066
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Adolescent Idiopathic Scoliosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K34524418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02428
K562_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184575
RAD21	ENCODE Transcription Factor Targets	1.0	null
BRD-K73768826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21514
CGRP receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.681
GSE189653,GSE203344_2_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0555238
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEMA4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00707542
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63436213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1735
medial geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00458
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09525
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-684-PTF1A_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
FFAR4_KO_GDS4811_507_mouse_adipose	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853269
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022483
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1227
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_EA-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32794
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.2305
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0686
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173942
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0412086
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03034
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5197
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.21402
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0428087
K562_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188964
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05542
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AKT1_knockout_215_GSE39699	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.63316
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71719
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cleft palate, cardiac defects, and intellectual disabillity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
K562_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217812
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57732605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08004
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.63617
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_69_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10199
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OSTABOLIN-C	DGIdb Drug Targets 2026	1.0	0.588133
RPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57556
mitochondrial part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050924
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5006
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29132
NCIH2452	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.02038
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189307
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
medial (fastigial) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57819
[D-Trp<sup>12</sup>]PTH-(7-34) (bovine)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
Lhx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2137
hsa-miR-4643	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Subiculum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.148
BRD-K23162004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83365
CRCGN014_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82478
K562_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162206
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.892955
BRD-A01403444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.211
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.79545
GSE164494_1_v_2_rab22a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64315
K562_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021601
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169117
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Duodenum Mucosa	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.6603
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19786
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5556
CEBPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0141333
BRD-K86903429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47599
SCML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24614
m1Lim part of the midbrain reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87889
20371479-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE164505,GSE164506_3_v_1_indisulam_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XOT4-0726-SM-4GIAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03981
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6826-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148653
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00658
MAPKAPK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00304271
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97767
molecular_function	GO Molecular Function Annotations 2015	1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K59657378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51707
Parathyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.087
periventricular stratum of r8Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00672
inferior frontal gyrus, orbital part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.96031
RAD21_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intermediate pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03649
BL2388 (CUL4A)	NURSA Protein Complexes	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005154
PFDN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46146
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.863015
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01163
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96429
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14528
BRD-K99856384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62168
DRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24981
relation	GeneRIF Biological Term Annotations	1.0	null
CCDC122	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541823
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0934096
parathyroid hormone receptor activity	GO Molecular Function Annotations 2025	1.0	null
K562_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0480134
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0692472
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
CAOV4	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.20781
DoTc2-4510	GDSC Cell Line Gene Expression Profiles	1.0	1.83335
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04472
A253	CCLE Cell Line Gene Expression Profiles	1.0	1.4489
Interposed nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40424
BRD-K45811188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90501
BRD-K74663731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00857
K562_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015066
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW22	DepMap CRISPR Gene Dependency	1.0	6.41273
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K05635176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0979
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936221
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70921
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMSB4Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36384
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02964
ligand	GeneRIF Biological Term Annotations	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39063
similar	GeneRIF Biological Term Annotations	1.0	null
K562_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256445
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ASIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53069
UBOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505361
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.5902
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051894
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182577
KLF15_Deficiency_GDS2687_649_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48533326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08005
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF217-24962896-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.04866
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24906
USP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26617
K562_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0311701
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213349
NCI-H1568	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K82105033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57499
BRD-K73402542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40934
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00167
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10798676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45069
BRD-K21680192_mitoxantrone_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
hsa-miR-3064-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
TRPV6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00600687
GSE147366_3_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JHOM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35658
LIMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68881
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancytopenia	CTD Gene-Disease Associations	1.0	1.08442
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Entorhinal area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55254
GATA2_01_61	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.78374
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2106
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10198_KD_FIP1L1_SRP251753	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12337
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
UBE2E2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593126
RAD21_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206331
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
0225151-0000-6384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K23405268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08116
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.799
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r1 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05493
TNFAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31252
BRD-K96243955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17483
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3904
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189627
TEAD4_01_151	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61285
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62714
ZNF341	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23428
SETD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472287
BRD-K37280550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02226
ovary_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38334
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41O-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ile	GeneRIF Biological Term Annotations	1.0	null
BRD-K08829593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32482
CLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530538
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178184
MLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11846
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03753
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSG	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.34059
mitochondrial membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.063897
BRD-K60898929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8343
PRKCB	KEA Substrates of Kinases	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ES6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.943023
PROCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01424
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KYSE520	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
liminal alar domain of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08941
release	GeneRIF Biological Term Annotations	1.0	null
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03557
dorsolateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36406
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06324
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A896-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168043
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Cestode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4889
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169246
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
[ILE5,TRP23,TYR36]PTHRP-(1-36)-NH2 (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
Learning Disorders	CTD Gene-Disease Associations	1.0	1.24244
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5268
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74402
EX229_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0190831
BRD-K78816149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08095
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Copula pyramidis, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08824
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61645
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43244
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5085
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210724
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40458
BRD-K61370861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35669
PMC11732233-mmc1.pdf-142-NANOG_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
SK-MES-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.29209
Nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
K562_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270296
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_Ref_Can-ZNF205_ZNF205	Rummagene Transcription Factor Associations 2026	1.0	null
K562_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163314
EZH2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840424
endochondral	GeneRIF Biological Term Annotations	1.0	null
TNFSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5092
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of isLim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23394
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330606
median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.705173
NRAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475032
CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_766_mouse_Skin - 0 Day	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ADH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00247972
UT7	CCLE Cell Line Gene Expression Profiles	1.0	1.68044
K562_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279077
DDX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5935
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.04562
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30929
K562_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291614
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome Pathways 2014	1.0	null
r8 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00672
BRD-K39030761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08385
S-Adenosyl-L-methionine (disulfate tosylate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0138957
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4985-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RSV-A2_24Hour-KO_RSV_None_GSE18170	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.96115
BRD-K47175449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76913
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
BRD-K58232861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62045
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01333
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060307
A498	BioGPS Cell Line Gene Expression Profiles	1.0	1.42483
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57863
Hypoparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.648
BRD-K18031793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91307
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990036
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10535
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.68215
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060216
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977342
BRD-K07020302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06571
SLR26	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04185
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BL4625 (RBMX2)	NURSA Protein Complexes	1.0	null
BRD-K57464717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05489
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59204
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.76327
CA5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550217
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16839
disease	GWASdb SNP-Disease Associations	1.0	0.031099
BRD-K82882121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27942
TM-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.094
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAMHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407787
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.883742
NDUFA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81253
Entorhinal area, medial part, dorsal zone, layer 6	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10909
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K13559806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00428
K562_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169753
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6057
ERLIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42523
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.717
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280193
BRD-K30863464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14077
Avian pallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.617
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929659
CGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36184
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06324
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0540996
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12159
GTEX-XUZC-0926-SM-4BOQF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0793
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.1957
intercalated amygdaloid nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08282
CFPAC1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.19859
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.26825
BRD-K22875065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19709
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
GTEX-R3RS-0626-SM-48FE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03569
r6 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63977
abnormal locomotor circadian rhythm	MGI Mouse Phenotype Associations 2023	1.0	null
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6126
Lung squamous cell carcinoma_LUSC_TCGA-85-7844-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63468
Amylin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
K562_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0495292
increased heart weight	IMPC Knockout Mouse Phenotypes	1.0	null
MPP89	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52842
Mineral metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.723
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29698
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
[His<sup>4</sup>  Tyr<sup>5</sup>  Trp<sup>6</sup>  His<sup>7</sup>]TIP39 (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MT-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AQP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25054
ARL5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20505
CORL47	DepMap CRISPR Gene Dependency	1.0	4.62986
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.033989
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27103
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.897
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28188
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900711
hydroxytoluic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3127
Monocrotaline_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0191691
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.605709
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82158
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.949437
Pollen wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
BRD-K13873561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61075
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7171
BRD-K07762753_Aminopurvalanol A_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVK-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE201042_2_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inner SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.843155
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41141507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35198
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830392
IFT80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61639
BRD-K24565713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31388
parasubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43104
Signal Transduction	Reactome Pathways 2024	1.0	null
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3032
BRD-K49584663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18917
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040752
Goserelin (acetate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268055
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-RNA-Seq_analysis_of_genes_associated_with_a_DHS_that_has_a_CEBPAx2_specific_Hi-C_interaction_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0578015
Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
serotonin-activated cation-selective channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.753
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
subiculum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.793543
BRD-K11506071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84808
Idoxuridine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0193469
Anthropometric traits	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959503
[ILE5,TRP23]PTHRP-(4-36) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11662217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17007
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4178
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06577
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Basis pedunculi cerebri	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
RUSC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00736473
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028842
Vertebra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.234
clemizole-3672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55392
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19147
Brain_CT2_Amex 419	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
Hypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.615
MAD2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25634
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9291
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17257
[His<sup>5</sup>]PTH-(1-34) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831032
BRD-K58614056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25842
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73443280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04692
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22541
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.22601
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.041807
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSC2	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.875457
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830887
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2318
Idiopathic Osteoarthritis	DisGeNET Gene-Disease Associations	1.0	null
U2904	DepMap CRISPR Gene Dependency	1.0	2.44523
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78085
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25663
[HIS5]PTH-(1-34) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
SNU449	CCLE Cell Line Gene Expression Profiles	1.0	1.35263
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29785
Endochondral bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.302
BRD-K60484506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43783
Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16322
SLC25A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00634026
hypoparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.565277
Brivudine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169133
intermediate stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00364
H3K27me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67329
TDOTT	DepMap CRISPR Gene Dependency	1.0	3.99714
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
K562_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190555
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1877
UBTF	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.844791
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07638
RHOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41502
ZNF382	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0916
LN464	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81014
Prostate adenocarcinoma_PRAD_TCGA-CH-5754-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59429
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270843
K562_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019431
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71572
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9508
BRD-K15157905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17317
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05692
19621087-Table1c	GeneSigDB Published Gene Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8441-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274628
mineral	GeneRIF Biological Term Annotations	1.0	null
POLR1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81553
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.81881
K562_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252009
KE39	CCLE Cell Line Gene CNV Profiles	1.0	1.64177
met	GeneRIF Biological Term Annotations	1.0	null
BRD-A41916216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78786
Diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.945
LJI308_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0109684
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lateral spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00937
BRD-K86050213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2767
GSE182680,GSE182683_0_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0356134
A7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.044
skin_5e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
dorsolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08185
CCK81	DepMap CRISPR Gene Dependency	1.0	3.03954
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0418765
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.973336
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.421765
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33371292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01531
H3K27me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipito-temporal gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.849183
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01384
Ropivacaine (hydrochloride monohydrate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0159894
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fractures, Bone	HuGE Navigator Gene-Phenotype Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-02A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF2	ENCODE Transcription Factor Targets	1.0	null
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84964
GTEX-T5JW-2026-SM-4DM63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21238
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935043
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9167
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPCR ligand binding	Reactome Pathways 2014	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288387
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TGM2_KD_GSE23702_716_human_NB4 cells, 72h ATRA-induced differentiation	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K63757821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.26273
K562_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0336333
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.044
CLEC4G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755749
H3K27me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRDM16_DEPLETION_GDS4021_460_mouse_WAT - white adipose tissue (stromal-vascular cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.042811
supragenual nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13998
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7409-01A-31R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05333
K562_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187756
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47399
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219643
Uvula (IX), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55062
Pontine nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.028
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236615
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.933032
Lung squamous cell carcinoma_LUSC_TCGA-85-8071-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FN3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05334
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
K562_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236878
r7 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01928
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31523
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mebendazole_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0241729
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.901602
C3A	CCLE Cell Line Gene CNV Profiles	1.0	1.42642
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318166
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.15293
20460173-ImmPortCD40LvsControl	GeneSigDB Published Gene Signatures	1.0	null
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	1.15952
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_2day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	3.01338
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07969
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207957
PCI-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.889448
BRD-K54455139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36483
BRD-K58644442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17957
CDK5_knockdown_99_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.72812
BRD-K88836117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00152
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
KHK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38032
TCF12	ENCODE Transcription Factor Targets	1.0	null
Amylin receptor complex 1	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.332
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166247
Medial longitudinal fasciculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50538
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7833
GPCR downstream signalling	Reactome Pathways 2024	1.0	null
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83174
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.897086
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
interstitial nucleus of the posterior limb of the anterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40765
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
RGMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27614
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.913041
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K41241300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25028
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
key	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-586	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
K562_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324651
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11984
Acute Myeloid Leukemia_LAML_TCGA-AB-2914-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171793
BRD-K68300789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72292
Anethole trithione_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0248113
GATA2	ENCODE Transcription Factor Targets	1.0	null
K562_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181558
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954642
BRD-K18783332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35655
PCDHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17527
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5654
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934425
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43645
BRD-K56272400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29395
Basal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.657
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177367
NCI-H250	GDSC Cell Line Gene Expression Profiles	1.0	1.52675
SF172	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.26092
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63129
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21115
CRCGN015_MCF10A_48H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36079
NMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39559
BRD-K73792260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58993
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K15128331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30881
Stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.73
Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15251
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.870217
BRD-K96054771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83236
paraventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.527139
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.367
substituted	GeneRIF Biological Term Annotations	1.0	null
VMRCRCW	CCLE Cell Line Gene CNV Profiles	1.0	1.79409
BRD-K85513337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45574
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834435
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07082
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179446
PTHRP-(7-34) (HUMAN, RAT, MOUSE)	DGIdb Drug Targets 2026	1.0	0.8822
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A6GG-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00022
PTH2	Guide to Pharmacology Protein Ligands of Receptors	1.0	null
[ILE5,TRP23]PTHRP-(5-36)	DGIdb Drug Targets 2026	1.0	0.8822
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SB-423562	DGIdb Drug Targets 2026	1.0	1.7644
ABALOPARATIDE	DGIdb Drug Targets 2026	1.0	1.7644
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.926946
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TSPAN9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588139
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8638-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84074
K562_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0414848
Sarcoma_SARC_TCGA-PC-A5DK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0296279
SOX2	ChEA Transcription Factor Targets	1.0	null
YPEL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95307
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.10962
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.61613
receptors	GeneRIF Biological Term Annotations	1.0	null
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187686
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.757
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999348
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1689
prefrontal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.368998
Nucleus sagulum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14802
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040577
Neurosecretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8354
PTH-(1-34) (rat)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Perturb_4425_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.73546
POM121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27664
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.01019
pyramidal layer of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00276
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98064
Nephrocalcinosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
BRD-K46561246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2352
H3K9me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZIC3-20872845-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.6689
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0915
Stroke	dbGAP Gene-Trait Associations	1.0	0.01628
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Liver hepatocellular carcinoma_LIHC_TCGA-UB-AA0U-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27055
K562_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.031378
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83267
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A5ND-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01506
BRD-K02329600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68676
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25696
SW1783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CAOV4	CCLE Cell Line Gene Expression Profiles	1.0	1.44736
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.451
17671232-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
hypersensitivity reaction type ii disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056975
H3K27me3_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88188
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00471
G alpha (s) signalling events	Reactome Pathways 2024	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IS-01A-21R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2043
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.84893
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-544b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ZFP57-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33538
PTH-(1-34) (RAT)	DGIdb Drug Targets 2026	1.0	0.8822
MAP3K19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489213
Paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.612
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990591
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06867
BRD-K90231936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1404
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52885
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOP-62	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CPSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36246
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2939-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89778
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022644
NCI-H2170	GDSC Cell Line Gene Expression Profiles	1.0	1.52156
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
EXTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34479
TCEA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11254
stroke	GAD Gene-Disease Associations	1.0	null
A172	DepMap CRISPR Gene Dependency	1.0	3.08902
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8688
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORL23	Achilles Cell Line Gene Essentiality Profiles	1.0	1.31722
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.227
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03594
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.93922
SNU8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.38789
LENG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4806
el2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.014
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975556
SP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944581
BRD-K57977694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68043
K562_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0370838
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34245
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
intermediate stratum of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7034
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	1.0	1.47424
OE19	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81888
TIP39	DGIdb Drug Targets 2026	1.0	1.3233
JHH4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56346
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042259
BRD-K53757555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48229
BRD-K70856965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20012
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34442
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32136
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11321
Tucidinostat_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0137581
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261581
NB13	DepMap CRISPR Gene Dependency	1.0	7.43123
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23714
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98541397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04602
Meloxicam_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0148336
NCI-H322M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26802
SLAMF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607176
Habenular trigone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.215
Lung adenocarcinoma_LUAD_TCGA-78-7536-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01424
K562_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0361294
intermediate stratum of Ist	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30488
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28329
ROPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057154
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
CTCF_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_ZIC3_20872845	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48733
H3K27me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
infralimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.915215
CNR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572856
H3K27me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-514	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.688817
BRD-K82064887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10801
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18155
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09103
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.939735
K562_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190645
CENPX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22374
GTEX-RU72-0626-SM-46MUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16651
HCC1395	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9017
BRD-K19958830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35485
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6N0-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PISD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17435
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO741	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56413
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.30367
BRD-K99660943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71454
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.964689
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6949
RVH-421	GDSC Cell Line Gene Expression Profiles	-1.0	-1.74857
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184677
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92479346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47543
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3071
Obsessive-compulsive disorder or autism spectrum disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51270604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14472
BRD-K44007425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18809
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191427
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41676
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75062
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0879484
behaviors	GeneRIF Biological Term Annotations	1.0	null
RXF393	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42637
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0632182
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146373
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Celecoxib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0241196
Pinealocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.004
Nodulus (X), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80563
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899619
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5441-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81277520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08706
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.91
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.8525
SOWAHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38725
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7Q0-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
investigated	GeneRIF Biological Term Annotations	1.0	null
HSC-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46906
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904438
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0855973
K562_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0447059
BRD-K00590556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15512
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.7265
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154115
corpus striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09762
parathyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.524974
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MIAPACA2	Achilles Cell Line Gene Essentiality Profiles	1.0	1.37004
GSE254770_0_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
salivarygland_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.03832
TTC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20676
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14371
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A02799884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15174
HT1197	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51341
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8608
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hypophosphatemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.97849
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22596
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
auditory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.535438
K562_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290332
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0604509
POLR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17547
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888675
hsa-miR-548aj	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
LP1	DepMap CRISPR Gene Dependency	1.0	2.1549
tocainide-2931	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Leukemia, Adult T Cell_Blood monocyte_GSE10789	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.87136
16527891-Table1	GeneSigDB Published Gene Signatures	1.0	null
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
pth2r	GeneRIF Biological Term Annotations	1.0	null
BRD-K06049932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10969
spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.986728
oxaliplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74682
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0412615
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59096
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Subthalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
Premature Menopause	DisGeNET Gene-Disease Associations	1.0	null
r9 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26694
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WDR89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19429
end stage renal failure	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.210925
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ligandreceptor	GeneRIF Biological Term Annotations	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
subsequent	GeneRIF Biological Term Annotations	1.0	null
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acetazolamide_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271634
SOD2_KO_GDS1080_128_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
pons	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08766
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.038933
TRNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88178
ChIP_ZFP281_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J7-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.581
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90402
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
leukemic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.504318
[D-Trp<sup>12</sup> Tyr<sup>34</sup>]PTH-(7-34) (bovine)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC251	CCLE Cell Line Gene Expression Profiles	1.0	1.75791
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
Nucleus of the optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18675
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33977
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02138
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08467
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
GTEX-P4QT-2026-SM-3NMCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06411
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226382
LB-100_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0125843
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25968
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51101
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.587228
Median eminence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.702
Subiculum, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00386
dorsolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.896136
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
involvement	GeneRIF Biological Term Annotations	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCA1_Knock-in_GDS1756_232_mouse_Cerebellum tissue - 12 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150619
GPCRs, Class B Secretin-like(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-Q2AG-0326-SM-48U1O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17399
NANOG-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08636
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EK-01A-22R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8403
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194335
Loperamide (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.018699
anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.581217
BRD-K22875057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23989
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30541
K562_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175567
RTEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54546
mantle zone of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43158
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47756
intermediate stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05734
cancer stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.18788
Sarcoma_SARC_TCGA-DX-A23Z-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
levocabastine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42859
BRD-K08109215_I-BET_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16118844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18536
RAPA_EARLY_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
NANOG-21062744-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PTHrP-(1-21)/PTH-(22-34) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP2	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.16044
hypertension	GWASdb SNP-Disease Associations	1.0	0.514703
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00444
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.123
GTEX-NPJ7-0011-R1a-SM-3GACT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90569
UXT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546968
BRD-K67090705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02951
NCIH2887	DepMap CRISPR Gene Dependency	1.0	3.57239
salivary gland	GTEx Tissue Gene Expression Profiles	1.0	0.836372
BRD-K89264608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27671
NVP-BHG712_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00920835
Gemcitabine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.024659
kidney disease	GWASdb SNP-Disease Associations	1.0	1.06224
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61884
Lung squamous cell carcinoma_LUSC_TCGA-85-8070-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NHLRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3088
perilemniscal isthmic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24369
BRD-K10211218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23791
GSE149075_8_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101112_0_v_2_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r4 part of descending trigeminal sensory nucleus, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02861
STAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32101
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.05573
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14527
BRD-K41287744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4632
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.34311
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.287352
CRCGN014_HEPG2_3H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24049
LCLC-97TM1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.856626
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8224-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NB7	DepMap CRISPR Gene Dependency	1.0	5.09503
GSE153443_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26857
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55778
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.23452
GSE133927_1_v_3_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEL4-2126-SM-447AE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2332
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28329
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94121
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056209
BRD-K37872081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33333
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06324
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.2461
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831208
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237137
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K86938753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17596
Preotact	DrugBank Drug Targets	1.0	null
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01696
NH12	DepMap CRISPR Gene Dependency	1.0	3.39958
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1647
BRD-K13798725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22708
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02937
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2307
HUH1	CCLE Cell Line Gene CNV Profiles	1.0	2.15402
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496335
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hexylresorcinol_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182545
abnormality of the cerebral vasculature	GWASdb SNP-Phenotype Associations	1.0	0.235255
SERTAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81155
NCIH510	CCLE Cell Line Gene Expression Profiles	1.0	2.54148
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus preopticus medialis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.784
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.824641
BRD-K05057860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1491
MOTN1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67325
chronic kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.160574
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93719
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00123
RAD21_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844231
BRD-A04258855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02878
fractures, bone; osteoporosis	GAD Gene-Disease Associations	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PARATHYROID HORMONE	DGIdb Drug Targets 2026	1.0	0.735167
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
BRD-A02214146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72217
K562_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192708
GAMG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6673
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88542817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64014
FTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45981
BCAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39934
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.36073
Torkinib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0350508
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3889
BRD-K86855109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26607
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.947
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Encorafenib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156422
SK-MEL-24	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16936
BRD-K15028515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10135
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2759-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275425
PDXP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12148
epitiostanol-4204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0297121
BRD-K03063480_PF-477736_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.71393
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56176
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202967
BRD-K18979455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33168
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048465
K562_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179143
kidney	HPA Tissue Protein Expression Profiles	1.0	0.762688
hsa-miR-3125	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TIP39-(7-39) (HUMAN/BOVINE)	DGIdb Drug Targets 2026	1.0	0.8822
density	GeneRIF Biological Term Annotations	1.0	null
BRD-K10635555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41225
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11223
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.873427
LMAN2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22462
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54791
cerebellar nuclei of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20457
YPEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42359
BRD-K34274486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22385
anterior pretectal nucleus, ventral core part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09846
GTEX-WXYG-2226-SM-4E3IM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40312
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38318
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.353282
SDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04308
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233946
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73707
SA1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ROBO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528625
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28108927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43835
BRD-K88080911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28093
K562_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0316776
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89679
communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.656441
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27767
K562_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226898
TOM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92548
Hip	dbGAP Gene-Trait Associations	1.0	0.08422
Disseminated Intravascular Coagulation	CTD Gene-Disease Associations	1.0	1.0637
BRD-K60389305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89882
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177158
postnatal	GeneRIF Biological Term Annotations	1.0	null
BRD-K82877426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11356
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LY2090314_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0102908
reported	GeneRIF Biological Term Annotations	1.0	null
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CALB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587235
GTEX-XV7Q-2326-SM-4BRVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58292
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.20024
MJ	DepMap CRISPR Gene Dependency	1.0	4.32782
K562_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0574248
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3079
PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-SYMBOL_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31711
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56899
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11975
BRD-K84401063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38646
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216062
BRD-K11004561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29714
Pons	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08542
GTEX-TMMY-0726-SM-33HBE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25532
different	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUPHD1	CCLE Cell Line Gene Expression Profiles	1.0	2.23937
nociception	GeneRIF Biological Term Annotations	1.0	null
BRD-K46897949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14397
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196853
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027983
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84708
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58305
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017604
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.12627
IOMMLEE	Achilles Cell Line Gene Essentiality Profiles	1.0	1.46869
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24522
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OC-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0307019
BRD-K46805838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54495
subcuneiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48984
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
OCIM1	CCLE Cell Line Gene Expression Profiles	1.0	1.46719
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3509
Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245689
reticular formation of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02782
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0976
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.848967
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18447
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CR-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.702308
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5379
G protein-coupled receptor activity	GO Molecular Function Annotations 2023	1.0	null
K562_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025437
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95823
IL11RA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52129
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0545828
BRD-A57174914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01265
BRD-A97198094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03012
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08179
Ectorhinal area/Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0863
coupled	GeneRIF Biological Term Annotations	1.0	null
HEYA8	Achilles Cell Line Gene Essentiality Profiles	1.0	1.5741
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QO-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7849
GSE198165,GSE198166_5_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.531
BRD-K09366011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13719
BOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19253
MDA-MB-231	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02339
BRD-K07482874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94015
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AML193	Achilles Cell Line Gene Essentiality Profiles	1.0	1.03133
hsa-miR-548ae	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
K562_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0540263
Sarcoma_SARC_TCGA-DX-A3U5-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior occipital gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15012
Lactate (calcium)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.015727
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77293
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929659
positive regulation of metabolic process	GO Biological Process Annotations 2023	1.0	null
K562_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0356028
20103679-ST3-C	GeneSigDB Published Gene Signatures	1.0	null
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0445277
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.869022
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.918574
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nipple	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.287
EIF3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56231
BRD-K32170456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32477
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92266
20460173-ImmPortCytokineReceptors	GeneSigDB Published Gene Signatures	1.0	null
superficial stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13914
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022692
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09804899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0036
End stage renal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
BRD-K60743396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47292
BRD-K40452322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18572
[ILE5,TRP23]PTHRP-(1-36) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
middle frontal gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.869204
Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14527
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05970499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14651
BRD-K10459843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37674
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2958
molecular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4443
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0723682
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34662
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6259
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SCC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50742
Fastigial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41838
isthmic part of the intermediate lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40301
pthreceptors	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071042
K562_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178125
GPCRs class B secretin like	WikiPathways Pathways 2024	1.0	null
K562_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193102
G protein-coupled receptor activity	GO Molecular Function Annotations 2025	1.0	null
NCIH2066	CCLE Cell Line Gene CNV Profiles	1.0	1.49714
BRD-K39813155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57695
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4749
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.269701
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hormones	GeneRIF Biological Term Annotations	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040305
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29392
SJSA1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.02988
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50145
MDAMB231	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73269
ARG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601353
GDM1	CCLE Cell Line Gene Expression Profiles	1.0	1.53847
CRCGN015_MCF10A.TP53.M_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2076
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ixazomib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251398
K562_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.03414
[Ile<sup>5</sup> Trp<sup>23</sup>]PTHrP-(1-36) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
TRAPPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08752
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01235
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
meglumine-3068	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73444
superior parietal lobule, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.889979
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72609226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17136
hsa-miR-3692	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
K562_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150489
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02129
PRPF40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90535
SMC3-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hypersensitivity reaction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05073
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.26863
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88188
chr2_208369969_G_T_b38	GTEx eQTL 2025	1.0	2.59367
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845405
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04278
CTBP2	ENCODE Transcription Factor Targets	1.0	null
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162301
Synostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
KINGS1	DepMap CRISPR Gene Dependency	1.0	2.74349
[PHE23]PTH-(1-34) (HUMAN)	DGIdb Drug Targets 2026	1.0	0.8822
K562_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139543
lateral orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27516
K562_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163157
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59648
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18359
(R)-Verapamil (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208437
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGF2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00385462
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09919
Hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.957
LN215	CCLE Cell Line Gene Expression Profiles	-1.0	-2.11099
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015475
ATP5F1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00449586
BRD-K00882360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58889
PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
ATP5F1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.88918
Nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29817
BRD-K62370517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26872
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11787
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7421-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of cold-induced thermogenesis	GO Biological Process Annotations 2025	1.0	null
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240714
BRD-K73357010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38748
Clofarabine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0335326
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, medial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54157
A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_1day-MOI-10^4_None_GSE37572	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.8007
DNAJC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52166
Muscle Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
SALL4	ChEA Transcription Factor Targets	1.0	null
ABC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MEK_INHIBITION_GDS5029_278_human_SW480 KRAS-mutant colorectal cancer cell line - 4hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Methotrexate_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0190052
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Artemether_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0274314
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05104
BRD-K23499378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00898
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9081
BRD-K38111331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1865
Scoliosis, Isolated, Susceptibility To, 3	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pulvinar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
BRD-K96925976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22256
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.16497
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
Orofacial cleft 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
insights	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022541
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0281428
WB-4101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30239
Area postrema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00608
GPCR, family 2, secretin-like, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
CCNJL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38707
K562_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169278
LPCAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6228
ARRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39004
BRD-K79355381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00054
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19834
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.55617
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.716075
GTEX-RWS6-1326-SM-47JXB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945675
CTBP2-25329375-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Penfluridol_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0249464
RNF169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44182
BRD-K47804666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65261
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4934
ACTR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03729
BRD-K87541124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06532
decreased core body temperature	MGI Mouse Phenotype Associations 2023	1.0	null
Retinoic acid_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.019955
BRD-K66479240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02921
BRD-K46839342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39924
PMC9618568-41467_2022_34255_MOESM5_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.863166
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2596
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^3_None_GSE43302	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.62685
PMC9950457-mmc3.xlsx-GRHL2_overexpression_DOWN-gene_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BL7341 (WDFY3)	NURSA Protein Complexes	1.0	null
K562_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303998
kidney	GTEx Tissue Gene Expression Profiles	1.0	1.64877
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040379
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.04389
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0324087
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0418641
superior temporal gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.844619
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44431
SUV39H2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00458973
K562_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200984
CP67-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987961
demonstrate	GeneRIF Biological Term Annotations	1.0	null
receptor activity	GO Molecular Function Annotations 2015	1.0	null
Endopiriform nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17393
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83645749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19443
GATA3	ENCODE Transcription Factor Targets	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.24206
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-514b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
fibrillar collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.106318
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CH-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18155
Lateral geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.85523
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.15568
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6972
Chondrodysplasia Blomstrand type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.812
MAX	ENCODE Transcription Factor Targets	1.0	null
Brain_CT2_EMSN 229	HuBMAP ASCT+B Annotations	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239436,GSE239441_0_v_1_keap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.870508
GTEX-QVJO-1826-SM-447C9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0033
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lobule II, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24043
LRRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28007
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14839
BRD-K75900952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00052
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37132
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08272
BRD-K19387722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08693
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188822
SIRT4_KO_GDS4823_505_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
K562_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221712
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16976
BRD-K64811593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52601
isthmic vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22834
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
ICAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00385461
GRHPR	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.868112
EZH2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32051
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.04042
HEC108	CCLE Cell Line Gene Expression Profiles	1.0	2.91797
Thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.809
GSE164494_1_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Prelimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
used	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K90311252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06369
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.856631
Hip bone mineral density and total body fat mass (bivariate analysis)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
Entorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45674
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.55491
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0401876
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.959217
Medial septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
Pasireotide (acetate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199283
hsa-miR-4659b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.038992
MCAD_KO_GDS4546_423_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K76628294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18557
Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75G-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0620943
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08043
C-fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.328
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1151
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.14797
H3K27me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6862
BRD-K45185240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0437
paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.705993
Tirabrutinib (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0117397
anterior digastric muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28731
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
CRCGN011_HEPG2_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0513
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K91588908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12924
EVSAT	CCLE Cell Line Gene CNV Profiles	1.0	1.54386
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21438
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.91391
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20743
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CX-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0333473
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VPS36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14611
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.899025
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.916069
K562_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01885
BMI1-23680149-NPCS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RNF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15428
HT1376	CCLE Cell Line Gene Expression Profiles	1.0	1.38369
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903266
OAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536818
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97547
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NDUFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20536
K562_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191462
spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215341
Amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.63
SEL1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23035
hsa-miR-4742-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
lateropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1996
BRD-K81450614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95249
SPRED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68446
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38334
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0481097
RRP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649454
Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57937572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.70243
superficial stratum of PaS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43104
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lateral geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.986
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
suggesting	GeneRIF Biological Term Annotations	1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93257
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Internal capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
BRD-K10540354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24752
BRD-A05956997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43905
BRD-K54939987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02336
[Phe<sup>23</sup>]PTH-(1-34) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Niclosamide (olamine)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0142614
MTURN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08132
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12226
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968909
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.753256
K562_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.030516
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
leu	GeneRIF Biological Term Annotations	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06784595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08537
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.10292
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CLDN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67134
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.54969
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98890753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37374
MSI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45606
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216739
MAFK_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10346
COR-L23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4067
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165975
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
MCC26	DepMap CRISPR Gene Dependency	1.0	2.55542
SLC12A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692218
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208211
Salivarygland	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.874979
CRCGN010_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17486
BRD-K81608755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13197
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00945
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11163
neostriatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.154841
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90982
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14431
PMC9927941-jci-133-163612-s045.xlsx-Sheet1-Table_S11_DEGs_with_a_PAX5_binding_motif_as_identified_by_Pscan_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
NOP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5078
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.792293
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7422-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29563
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188293
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.925479
OVSAHO	CCLE Cell Line Gene Expression Profiles	1.0	1.43458
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
K562_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144109
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3
PMC8700745__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CAS1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.20257
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920183
Perirhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
LPIN1_OE_GDS2291_587_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.554
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinarybladder_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Brain Lower Grade Glioma_LGG_TCGA-DB-A64W-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.82179
lateral ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248683
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.96778
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.96775
BV-173	COSMIC Cell Line Gene Mutation Profiles	1.0	null
J82	DepMap CRISPR Gene Dependency	1.0	2.01679
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.595255
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.846283
Adrenocortical carcinoma_ACC_TCGA-OR-A5K5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158744
collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.060838
Proglumide_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0216407
Lobule III, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13247
K562_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306056
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eiken syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
Testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.223
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18508
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06838
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926126
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7242-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202832
KLF4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K48406740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51328
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06124
Dorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07771
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6997-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053721
BRD-K32862383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52288
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173285
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3741
Lung cancer (asbestos exposure interaction)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3199
CRCGN015_MCF10A.TP53.M_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2485
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K54604127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82175
ZNF771	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8984
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2849
r5 part of the oral Sp5 subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13662
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3244
BRD-K73539077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19929
lomefloxacin-2348	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subtype	GeneRIF Biological Term Annotations	1.0	null
yohimbine-1763	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929659
BRD-A40504327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0383
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.875
SNRNP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69059
kidney_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.5579
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Anterior olfactory nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.83951
CHD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68981
OVCAR4	BioGPS Cell Line Gene Expression Profiles	1.0	0.962208
Caudate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
K562_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183062
PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60886324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64413
superior occipital gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18689
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00909
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831032
Chondrogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.567
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tofacitinib (citrate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0223421
CASS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590242
BRD-K73995655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17392
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01078
Brain Lower Grade Glioma_LGG_TCGA-HT-7881-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.87177
PMC10973470-41698_2024_570_MOESM1_ESM.pdf-353-NR2F1_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNG1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61644
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.835954
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH226	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82607
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1298
BRD-K39037393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03608
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IFNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531464
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A39506880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12523
K562_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190885
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36787
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831032
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68605096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21604
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.87476
CL-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K80921954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1831
K562_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0578751
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CT-01A-31R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21724
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ISOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99007
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4958
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
lateral tuberal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04233
Nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10716
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.913959
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155302
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23265
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0317471
PFKFB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21053
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.173832
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.065287
K562_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0314913
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1878
SP in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.920562
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24427
Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Radial glial cell_Embryo_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Reactive cutaneous fibrous lesion	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226692
MAFK	ENCODE Transcription Factor Targets	1.0	null
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.37966
trp	GeneRIF Biological Term Annotations	1.0	null
GTEX-S32W-2026-SM-4AD6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51458
XPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94129
Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165821
BRD-K44799944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08937
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00752
CFAP126	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45392
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015803
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00418
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.913959
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRCA1_DEPLETION_GDS2189_121_human_MCF10A mammary epithelial cells (MECs)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K82050323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64817
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.869882
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.925269
BRD-K91290917_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4687-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10113
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317799
tegmentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.687592
BRD-K86746660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30072
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88188
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-520d-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09192
Bardet-Biedl syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2664
Lung squamous cell carcinoma_LUSC_TCGA-39-5027-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.997068
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42158
LACTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29081
G protein-coupled peptide receptor activity	GO Molecular Function Annotations 2023	1.0	null
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0802381
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MACROH2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55974
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10531
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54666
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62624148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23471
CCKBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48358
Infundibulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.627
Perichondrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.072236
BRD-K88658905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32789
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.5507
positive regulation of cold-induced thermogenesis	GO Biological Process Annotations 2023	1.0	null
anterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16837
K562_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194374
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.609332
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
K562_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210866
SLC20A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22807
ACADS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68401
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29E-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
smallintestine_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
HS940T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63805
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37427
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02938
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31065
15869706-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K97763545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24713
Arcuate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.171
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36027
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.265