association	dataset	threshold value	standardized value
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K57977694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14571
RORB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629035
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305859
BRD-K43989220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49916
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226706
BRD-K35975002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11149
BRD-K54948591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99447
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pleopod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.862
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.569457
LC-03-KY64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218237
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4047
BRD-K97985992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14698
KCNQ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75175
BRD-K17705111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04111
CRCGN017_MCF10A.WT.HP_24H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07775
PWWP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18053
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110708_0_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38692266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73948
GSE114992,GSE114993_9_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.996
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.813657
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57388326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.65716
GSE128333_4_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
UPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16272
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40448
BRD-K22610244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86195
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LSM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461357
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4109
BRD-K59028365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1902
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
PHC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513317
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42143
IL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00447882
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A77941182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65407
GSE169155_6_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	9.21192
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_0_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
DCP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07854
BRD-K83949633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03152
BRD-K63462027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07393
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100607_TCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26031
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear telomere cap complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
BRD-K97081185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37655
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110708_2_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOLM-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7445
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MED29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0529
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9215
NDOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11918
K562_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134539
EPPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74502
BRD-K10398797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32573
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.105
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6459
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD-26-MB82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224599
BRD-K56973599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99066
DNA replication factor A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.783
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03168
BRD-K36176998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26553
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220078
BRD-K14166654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1212
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4157
H2BC11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060882
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4122
7389_RNF34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663413
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_4_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157049,GSE157051_6_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PRKN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544802
GSE226249_5_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K58892587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0606
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5837
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84443
BRD-K99036206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69327
BRD-K63487554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24995
CRCGN008_HEPG2_24H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48165
NID1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480578
THNSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512947
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-42-US78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295668
SATB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28004
GSE196540,GSE196542_4_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-95-BX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260633
BRD-K73608149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83369
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44598
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77281
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294961
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.75387
A549	DepMap CRISPR Gene Dependency	1.0	2.23706
BRD-K44664883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30755
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_5_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62377
EW22	DepMap CRISPR Gene Dependency	1.0	2.76396
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.82367
BRD-K87580376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06204
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.593536
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02892
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.515171
BRD-K47980183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12008
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.021
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57565
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.004
RPE1SS119	DepMap CRISPR Gene Dependency	1.0	6.84441
6-phosphofructokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.728
GSE210667_3_v_2_rfx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71772
BD-49-MD69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250123
RPL28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70385
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28748
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE128076_2_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00325
ZSCAN31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11572
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3664
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K48389907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33963
GSE128076_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3547
BEND3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677345
BRD-A57457448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37244
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA repair	GO Biological Process Annotations 2023	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22988
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUDT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515896
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4211
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3774
MTNR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694599
GSE216538_0_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352858
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.743
BRD-K20030272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59086
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_0_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A22089150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22896
496100456_TCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04799
Peripheral nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
BRD-K28488100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47153
Splenic marginal zone lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
CRCGN014_HEPG2_3H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14105
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60123410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8288
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144500_7_v_6_ventx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.531214
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539044
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154936_3_v_4_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K35188988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57349
LHCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00815735
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.57348
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	183.105
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
thrombocytosis	MGI Mouse Phenotype Associations 2023	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.711689
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cockayne syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	3.63495
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51490301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2449
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ku70:Ku80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.097
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184087_2_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144443_5_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNU2535	DepMap CRISPR Gene Dependency	1.0	2.75289
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17582293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31536
Sweat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.033
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24763
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61416
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130962
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250247
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-D_HEP3_DN_NR2F1_Ind_DN_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128076_2_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Creb5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5037
NE-29-VB58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334853
RPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08084
BRD-K31521981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80653
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF324	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05507
BRD-K13301506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68052
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97682096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04571
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5351_PWWP3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.659611
CCC5	DepMap CRISPR Gene Dependency	1.0	2.89277
BRD-K71644199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41306
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03073
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95656102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4924
ZCCHC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00474366
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84271229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43689
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1
ZBTB48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25284
BRD-K72591075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59885
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC6A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606658
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259311
ROCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673322
BRD-K41026056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05336
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11095
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Subdural space	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49126
DFFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00354659
BRD-K60092199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01203
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF823	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02514
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.242
BRD-K12260863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37546
BRD-K02778241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07645
GSE168076,GSE168080_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_6_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FGFR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050263
5470_NAT10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.4796
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25002
LRWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43089
Ro 48-8071	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
BRD-K95508535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13749
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Diffuse large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.995
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25066
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spleen cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.767019
GSE188774_1_v_0_hkdc1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8236
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65326
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4609
Collagen beaded filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39057
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270596
ACY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3909
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNF207	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09188
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1076
BRD-A52794651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67037
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A68913459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92854
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.69305
STAB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00459438
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BLM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00851095
ARHGAP24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534834
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.671853
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
protein-DNA complex organization	GO Biological Process Annotations 2023	1.0	null
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM209	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28729
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10163
BRD-A95480808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0997
BRD-K13401825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9735
BRD-K62497619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04518
BICR10	DepMap CRISPR Gene Dependency	1.0	3.50329
CEMIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06595
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.3621
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IGSF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591369
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPE1SS48	DepMap CRISPR Gene Dependency	1.0	2.6024
496100332_HIP_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00791
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324774
JF-84-QZ64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206107
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173282_1_v_0_marchf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40862705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39361
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300578
GSE158834_1_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60587793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28599
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ino80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.973
BRD-K96893659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2658
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369322
BRD-A97759891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00403
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7696
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155193
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC1A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00454454
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
ES4	DepMap CRISPR Gene Dependency	1.0	2.90103
BRD-K40057256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22907
LIVF001-029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0466
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39621
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.76275
Meninges sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
BRD-K85474153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25885
BRD-K80439500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08816
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC22A18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657343
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.869
5770_NPM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533364
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59612
VSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47533
BRD-K13792178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12106
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABRQ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677281
increased blood urea nitrogen level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2316
CPT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556461
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25709301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83095
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.977
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624776
Central nervous system hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A38359809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4213
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0033
BRD-K73539077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20797
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505291
Swr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.848
CCDC142	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27462
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dilazep-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05698
BRD-K64055724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01888
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2786
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2093
ATP5F1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37342
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
BRD-K63984483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05707
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE238018_3_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8771
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8508
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42214389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32589
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.69
AA-85-LB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420314
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13074426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40939
BRD-K57516590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07636
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21537
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06333
BRD-A06578049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12652
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Leukocyte disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1572
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Birabresib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.0
BRD-K75807882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31865
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.30963
GSE221577_1_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85311003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07263
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0324
GSE145430_0_v_1_zmat3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72386335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01195
BRD-K21927299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12251
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.488
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K51743001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52669
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.67
BRD-K47349976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54281
BRD-K19752998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13862
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.574546
CST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16879
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320634
GSE116433_1_v_0_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28448768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20995
K562_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165721
GSE231720,GSE231724_3_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
increased vertical activity	MGI Mouse Phenotype Associations 2023	1.0	null
MTMR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42642
EDNRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84278
BRD-K11493601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94619
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70515
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.0427
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.055
BRD-K07276022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14378
BRD-K53717076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14999
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9006
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.588259
GRK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00467344
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-80-GK24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423896
GSE160817_5_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6994
BRD-K23241743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87055
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STEEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31272
BRD-K20497425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19597
GSE199874_3_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76329
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	2.62397
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.6746
MTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14811
DNA-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.96606
BRD-K98841583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15022
BRD-K07460436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90697
DNER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06235
BRD-K35828963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48838
EOLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09728
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59859
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PANC0504	DepMap CRISPR Gene Dependency	1.0	2.70966
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70899
BRD-K49328983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06669
RIC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27195
BRD-A46317335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27594
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.211
Thyroid gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K47285393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06394
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45245
SSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65482
EJM	DepMap CRISPR Gene Dependency	1.0	3.13409
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.64734
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13987
BB-28-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455166
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10245467-mmc3.pdf-250-ZNF888_ZNF888	Rummagene Transcription Factor Associations 2026	1.0	null
Lamin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.511
BRD-K23957028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31063
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NEUROD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3063
GSE173394_1_v_0_nfatc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Myeloblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
BRD-K01371603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12108
BRD-K45665532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93375
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NTRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044162
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257251
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
CCNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22089
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.719536
CITED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25147
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103372_0_v_3_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95148987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65394
CST complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3433
BRD-K26094217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15697
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374314
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74618
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237426
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.641634
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26449
Seckel syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
JHU011	DepMap CRISPR Gene Dependency	1.0	3.4855
BRD-K91773518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03056
LSM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524805
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25229
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26636241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16798
BRD-K59445060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34824
BRD-K29711480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8427
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04443
BRD-K93148720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08994
BRD-K18958510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06877
GSE223008_0_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42575
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2827
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dapagliflozin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
BRD-K53110645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02417
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04765
BRD-K66675422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46176
PRIMPOL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07527
Disease of cellular proliferation	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K69901388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5417
LGR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08517
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.512193
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06786
BB-44-CQ48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200635
BRD-K71501826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11146
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12866026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53695
BRD-K76551930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43951
CRCGN015_HEPG2_48H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03386
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.113
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6809
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29159
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4154
CRCGN017_MCF10A.WT.HP_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2064
nucleosome binding	GO Molecular Function Annotations 2023	1.0	null
hyperactivity	IMPC Knockout Mouse Phenotypes	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7269
NCOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.317
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7584
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K86155400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11006
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4291
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYBPHL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544907
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213219_2_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97495
PLA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549195
BRD-K36095954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85692
increased vertical activity	IMPC Knockout Mouse Phenotypes	1.0	null
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.0357
BRD-K95588139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03405
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28434
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55453160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87345
Trunk	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DNA metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_1_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39223685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45174
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.46513
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03345
BRD-K85275903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16688
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74665927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17493
GSE153757,GSE153758_0_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515463
RSC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42688
HT55	DepMap CRISPR Gene Dependency	1.0	2.93507
BRD-K11987248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09258
BRD-K71493640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5826
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_HA-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
PLXND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34336
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6365
BRD-K73929798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50804
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.5132
CCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27567
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRAME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09836
BRD-K48987279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56344
TBC1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39499
GSE196540,GSE196542_2_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.40793
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.659388
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.735668
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93981
BRD-K49981566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23413
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20102
NFE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2527
Telomere cap complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65465
BRD-K61223323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1227
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28526
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677685
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
RIDDLE syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.5821
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
NTSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521947
507_ARL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532927
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434297
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUDHL4	DepMap CRISPR Gene Dependency	1.0	2.16999
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30545
BRD-K22683888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11775
BRD-K87126326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82473
BRD-K92444813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35935
ZSCAN5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46218
TONSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40024
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K45013233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12507
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEIOSIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22952
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-32-EI69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288361
BRD-K17209411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62908
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	61.4691
BRD-K56065989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45388
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1846
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.6581
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16439
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE238018_1_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
GADD45B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00371928
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23435841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4896
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.694578
BRD-K22481359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62246
BRD-K47338154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95042
BRD-K88670720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05568
BRD-K98161738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24732
BRD-K11419664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14631
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32101
chromatin organization	GO Biological Process Annotations 2023	1.0	null
4107_IMP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635535
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Balicatib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K16694974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17462
BRD-K34741587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0944
BRD-K60631127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66493
SYNE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50858
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341284
BRD-K24020784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52017
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39938
PHLDB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051992
nucleus	GO Cellular Component Annotations 2023	1.0	null
BRD-K54384984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47288
BRD-K09693670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0774
GSE133516_5_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45893504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30436
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27889081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41269
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CCLP1	DepMap CRISPR Gene Dependency	1.0	5.16933
RAB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4282
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216538_5_v_6_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCT241533	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.4535
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327293
Central nervous system lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
BRD-A50287893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32162
BRD-K78245984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73678
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSTM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660288
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37685
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44069
GSE110708_1_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0238
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
GSE113817_2_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU1327	DepMap CRISPR Gene Dependency	1.0	2.10519
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE250534_4_v_1_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25877330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25283
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100641_PCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.64215
Throat	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47482563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05061
ZNF492	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43989
hyperactivity	MGI Mouse Phenotype Associations 2023	1.0	null
ANKRD33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85598
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ULK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595768
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4296
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15961
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H4C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5046
INKA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680651
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23355
GSE67266_5_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A57353172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20732
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40724407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20549
BRD-K25600773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55597
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09756
PMC3729906__F1	PFOCR Pathway Figure Associations 2023	1.0	null
HG3	DepMap CRISPR Gene Dependency	1.0	8.3892
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased circulating alkaline phosphatase level	MGI Mouse Phenotype Associations 2023	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.779652
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.37357
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.565888
ZDHHC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05448
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62256869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95945
JVE015	DepMap CRISPR Gene Dependency	1.0	2.25408
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2212
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3689
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.46665
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.504202
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6722
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.601
BRD-K73391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65775
KCNMB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596736
BRD-K46623934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22593
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8693
ZNF280B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481021
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30411
BRD-A15454510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21554
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHST14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14762
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.0534
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40271
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.54036
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.839638
FGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0050651
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSG5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582024
GSE223008_4_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278798
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44969
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.2566
DNA ligase IV deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
Gliclazide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
K562_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014702
PMC11342215-mmc2.xlsx-Protein_list-Table_S1_Protein_information_of_LC-MS_MS_data_from_one_analysis_between_FXN_KD_and_Ctrl_of_Ovcar5_spheroids_related_to_Figure_4_and_STAR_methods_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0246
ASH1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00442808
Vatalanib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
Palatine tonsil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
BRD-K00505499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52004
ASNS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00334339
GSE96544_1_v_0_mebendazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146074_6_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70305913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67775
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10525
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25452
GSE200352_10_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18199
BRD-K64353470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36835
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
BRD-K03861440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50075
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01452910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14361
BRD-K36474885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63487
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKNFI	DepMap CRISPR Gene Dependency	1.0	2.09055
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA1-B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.856
BRD-K71139459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11301
BRD-K45095313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74493
GSE138818_1_v_3_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04397
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598298
BRD-K85887470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27002
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.69
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ALG10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04415
CEACAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606581
BRD-K87530935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2941
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
I3C	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
BRD-K44360367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0929
BRD-K00083518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95809
BRD-K71881549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34299
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189941_1_v_0_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neck	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558155
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.13984
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215646
B4GALNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448325
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2495
CF-97-KZ12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287908
5205_MRPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.768775
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21784579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11702
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.05641
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37588779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0772
BRD-K93339508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20867
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6226
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0199
TTPAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00981
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521701
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53293966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06621
BRD-K80761625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63303
DEFB4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532503
RAB23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060522
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424545
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0806
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4317
Myeloid neoplasm	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.4538
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF709	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50795
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162384_1_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252452
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Isw1b complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.837
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477933
KB-78-BE93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267334
BRD-K95499061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34646
BRD-K96069147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56967
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17054
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9335
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14054
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411818
RERFLCSQ1	DepMap CRISPR Gene Dependency	1.0	3.73567
GSE196540,GSE196542_4_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLEKHJ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00435261
BRD-K36815183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17771
BRD-K31269097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09976
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757376
Leupeptin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.37295
BRD-K30103771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20598
GSE82104,GSE82299_1_v_2_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169155_3_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07420629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95965
BRD-K14961381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56697
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40542
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.502241
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW1463	DepMap CRISPR Gene Dependency	1.0	2.5362
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AK-54059	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0059
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.49772
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_11_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49159670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12038
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22689
BRD-K65823297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20328
BRD-K20435953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52208
BRD-K67403750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09651
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13187
AMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48222
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.82986
BRD-K50171760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05593
496100593_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18254
BRD-K52210941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82027
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83902026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3927
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.598909
BRL 54443	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2698
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97247086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51094
SNAI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00710085
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1177
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19387722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27337
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373191
SNAPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03339
BRD-K64451677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59495
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4797
BRD-K44692299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21894
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EBI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623198
PDE10A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527423
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325632
BRD-K52017042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9849
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.65787
SMC loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.009
SLCO6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632081
BRD-K23844489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71717
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11242872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84999
NONO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29085
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10569
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51835
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5
Bone marrow disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.34
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156257
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.82583
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256533
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.575885
ANO8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01539
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05719
BRD-K56588599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23064
BRD-K36778976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14901
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73277
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92795
BRD-K07614312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47085
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06313
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49744
BRD-A84816049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86169
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100319_HIP_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01271
BRD-K61494613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66558
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56605
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NURF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201381_0_v_1_bhlhe22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.802141
BRD-A24714998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67241
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060157
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.84744
BRD-K19776718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4025
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40715
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.744358
SLC4A1AP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487191
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone marrow cancer	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
RAB1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0235
FADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3035
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2462
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SULT1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11071
CEP120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62864
BRD-K10010414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33781
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43795
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70537701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05566
MMACHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625034
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3825
CLC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544282
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K35923751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30143
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chromatin organization	GO Biological Process Annotations 2025	1.0	null
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GD-82-CS38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215631
BRD-K63856509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74548
BRD-K54934070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21805
B3GAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02768
GSE202434,GSE202438_2_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2532
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.47376
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Genital pore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.988
BRD-A77181042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05322
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.326
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450811
g2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
GSE128076_1_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epipodite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.38
KLF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01809
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-03-XC62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221563
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01601
APMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06388
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.975
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEPACAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503945
CB-62-TB77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332885
BRD-K00209945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9009
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558882
RAPGEF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061075
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GMCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98052
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPE1SS6	DepMap CRISPR Gene Dependency	1.0	2.37201
BRD-K75206048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91152
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166315_2_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.786333
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.959411
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cancer	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Guanethidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384036
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72224143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20377
SLC19A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49035
PMC5303304-13073_2017_407_MOESM3_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S2_Genes_differentially_expressed_by_24h_RA_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585023
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47865
PGM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538832
BRD-K29628221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82557
GSE138468_3_v_6_dyrk1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Germinal center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.512
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNA damage response	GO Biological Process Annotations 2023	1.0	null
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34282646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30693
KARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75323
BRD-K50036850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06232
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
BRD-K37680172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33364
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.51385
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TUBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36463
BRD-K69872823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2637
GSE137818_3_v_7_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QPRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00330178
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83877780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16266
Hematologic cancer	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18958
XEN445	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
CRCGN015_MCF10A_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0491
GSE214212_3_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68955
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_7_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31602464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02411
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PJ34	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
BRD-K22510845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33938
BRD-K34026318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22039
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.628217
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Isw1a complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.813
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11282060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47317
BRD-K08715918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19201
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.4623
PMC12224833-12967_2025_6787_MOESM3_ESM.xlsx-DEGs_PDX1-GeneSymbol_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.982104
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2346
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50761
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68953461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15298
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74908937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06021
BRD-K56126872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27505
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92012390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00479
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1834
BRD-K02078984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53099
ae3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01449
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.810029
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.552
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mycophenolic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.28
BRD-K62621376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27377
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A56909893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6094
BRAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00842131
BRD-K91980109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45945
SMYD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17071
BRD-K87722624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12341
BRD-K96945247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01489
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GF-03-HI41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20771
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16823
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8978
CYP2C19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786551
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE109111_2_v_0_stim1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4938
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32275
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11716
DCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.459
BRD-K79199168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.149
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
WBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68844
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.699
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MMAC	DepMap CRISPR Gene Dependency	1.0	2.89446
BRD-K32491833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5458
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45245
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07300437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60813
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77101974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34153
GE-53-SM76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213426
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3634
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHLA90	DepMap CRISPR Gene Dependency	1.0	2.37169
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252197
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9569
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01224
BRD-K36352298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61756
GSE102675_2_v_1_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384026
CRCGN011_HEPG2_24H:N06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3427
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.935491
Imiquimod	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6202
BRD-K82793574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13997
Shelterin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.008
CENPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53043
GRIK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525824
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288242
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06582
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20426211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19157
BRD-K65265098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46808
Intravascular large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
GSE136627_7_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.377
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EXOC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29307
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327163
BRD-K30013099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29186
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06310280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2316
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6673
PMC6300607-41467_2018_7620_MOESM9_ESM.xlsx-common_BRD4-S_KO_MLL-AF9_loci-Unnamed_12_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36581
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75648723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25653
Spindle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
BRD-K76755209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28245
PSMD14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37615
GSE114992,GSE114993_8_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JHUEM7	DepMap CRISPR Gene Dependency	1.0	2.96081
SRSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47695
BRD-K93491540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.496
CRCGN015_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8691
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22280519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67747
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-D-HEP3_DN_AA_DN_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A18825024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35222
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.646069
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23101
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6863
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54025526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0982
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216608
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.29407
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.407813
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365928
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41475
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00832
BRD-K28184331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11439
BRD-K07390518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00664
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40210962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71336
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EPSTI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602756
BRD-K43543979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17648
BRD-K70090544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3699
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.408489
CRCGN015_MCF10A_48H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54871
BRD-K06219419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68928
Organ system cancer	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.93706
GSE103124_1_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91944762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73955
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4153
BRD-K39649774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45779
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79574
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DRD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00396432
NB1	DepMap CRISPR Gene Dependency	1.0	4.88288
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CNTN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616471
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86777
NDUFS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528338
BASAN syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
SIRT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403082
thrombocytosis	IMPC Knockout Mouse Phenotypes	1.0	null
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340447
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438404
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56126
KCNC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534293
BRD-K22778942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18615
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8903
LYSMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691461
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.898061
JA-23-QE71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213844
BRD-K24166534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08629
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K43684831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31563
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K83708628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5654
PHOSPHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70975
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_4_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4741
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8956
CRCGN011_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0619
GSE158834_1_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.910624
increased blood urea nitrogen level	MGI Mouse Phenotype Associations 2023	1.0	null
IRF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20029
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04513994	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13994
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PCSK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656193
BRD-K04695511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31661
INPP5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544536
BRD-K64425085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77452
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21714
TLDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37913
2,4-Dichlorophenol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-toNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PC-18-VX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237939
NA-30-EF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357602
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315128
CF-48-QD87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202307
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	2.59175
BRD-K45091989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.19343
BRD-A53381587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20028
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7761
3-Benzyloxyaniline	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.592
HRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00063
BRD-K69453385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26715
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211541
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38853406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07077
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43796
GSE151782_3_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4643
BRD-K82394273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40227
Hematopoietic system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02376
ZRANB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22816
GSE126127_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44415466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27442
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13526564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29715
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382721
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7677
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.763979
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515408
NPEPPS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647564
BRD-K92632379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43428
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4254
BRD-K57202089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98869
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342821
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.22695
AEBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050956
BRD-A05456882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31995
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Posterior lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61004
BRD-K72452130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53496
CASKIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31778
BE-17-CS60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256248
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.963637
GSE87144_3_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87615_1_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63359
WASF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07706
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4117
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7896
BRD-K20625691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07509
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6704
BRD-K95709431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12998
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224298
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.90217
FDX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478195
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233871
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207914_3_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2J2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16809
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PP2	DeepCoverMOA Drug Mechanisms of Action	1.0	0.54
PCI30	DepMap CRISPR Gene Dependency	1.0	2.03675
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06549
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC123	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75528
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.11335
ATP13A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579358
BRD-K66735566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74579
BRD-K97526959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81333
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.903
BRD-K23366960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16664
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30996
GSE231799_2_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
1910_CSRNP3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613059
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36265
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A29734477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33389
BRD-K39498165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33868
BRD-K90157100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28578
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.53061
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611326
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26582498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33093
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4558
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274369
SMCO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63169
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.484
496100610_TCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35161
CRCGN009_HEPG2_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05692
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111354
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395618
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3364
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55629
BRD-K90092568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01838
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74300740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59621
BC3C	DepMap CRISPR Gene Dependency	1.0	2.66452
BRD-K24047785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05899
BRD-K18984088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22313
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7867
BRD-K48092898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05811
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04866
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K48294384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50758
BRD-K45342423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50827
BRD-K36099605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2702
BRD-K69348766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77173
BRD-K86158100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51685
BRD-K53499221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23827
BRD-K66659401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10007
GSE71385_1_v_2_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41891
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AKAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12972
XY body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.22
BRD-K20398543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.336
CRCGN017_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03786
GSE103372_1_v_2_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A06471483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11337
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473884
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018498
DOCK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28607
BRD-K75672292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01921
S0-EE-Y79N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200077
BRD-K36796440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39986
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.897393
GSE112860_5_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98944347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26162
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K69184209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01087
BRD-K05902089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01561
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K29547381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72236
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44221
RBM10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531403
BRD-K57200567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28328
GABRE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487694
PLEKHG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81575
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6978
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154767_2_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196117_1_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11089039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15791
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73027631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01497
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
5205_MRPL21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621773
GSE216538_1_v_6_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00924
GSE100316_3_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STK066844	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481543
Subapical complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.834
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75806288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06295
BRD-K01329192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05226
BRD-A64985224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61835
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K57497543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31132
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351151
GSE199204,GSE211619_4_v_5_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K26079895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58124
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5925
BRD-K90238417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04786
KD-31-TU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270742
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37251
BRD-K34258713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15482
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52281
GSE180185_9_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K35296094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49999
BRD-K36196444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0472
BRD-K32373560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64381
BRD-A50837272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43498
BRD-K83875224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72177
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6652
BRD-K10157835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48868
GSE216538_0_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34486
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0597
Multiple myeloma	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
9424_TUBG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.726145
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24377650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28969
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313424
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1156
786O	DepMap CRISPR Gene Dependency	1.0	3.56897
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313959
MCIXC	DepMap CRISPR Gene Dependency	1.0	2.4232
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU1079	DepMap CRISPR Gene Dependency	1.0	2.71107
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04609
PSS131R	DepMap CRISPR Gene Dependency	1.0	2.21438
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61533770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02028
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.658263
SCAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31125
BRD-K20069402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51444
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322157
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HS729	DepMap CRISPR Gene Dependency	1.0	2.0048
BRD-K05745188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67552
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59484021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0831
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486957
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542246
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SGI-1776	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
BRD-K05118861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40891
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.516641
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226647
PRDX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00700889
BRD-K67835515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15918
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71293
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2975
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.52839
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A15330900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09141
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23947
BRD-K90316899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00596
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100384_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06723
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27902176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17078
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184087_4_v_5_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207963
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01686
GSE153757,GSE153758_1_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95798946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07943
BRD-A59683007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3823
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0971
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190950_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317606
ECC2	DepMap CRISPR Gene Dependency	1.0	3.98505
CYP3A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545569
BRD-K42814713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47272
USP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00687319
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20737
DNMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00366146
NCOA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00458585
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468765
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22955
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05119275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15685
BRD-K32403948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73386
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69528787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04218
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62224
RVH421	DepMap CRISPR Gene Dependency	1.0	2.6459
BRD-K90151990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18208
NB10	DepMap CRISPR Gene Dependency	1.0	10.283
OCI-AML2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K06152379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2852
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506345
GSE209582_1_v_0_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7332_RNASEK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534108
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Rix1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.075
BRD-K18856772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20914
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14197
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DONSON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04752
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87049
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5636
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100503_HIP_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08658
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.819432
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23291
decreased circulating alkaline phosphatase level	IMPC Knockout Mouse Phenotypes	1.0	null
Thoracic leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24386
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37592272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21439
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203158_5_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78074905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17746
GSE114992,GSE114993_0_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70935154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44149
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.567
BRD-K25649458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60312
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27962
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71605668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11922
BRD-K31546068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17966
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.944294
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25295
GSE136627_3_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	1.0	null
INO80-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00943
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75259
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
chromosome, telomeric repeat region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6356
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Colon ascendens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.22
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
WDR12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11697
BRD-K61271364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17716
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.83991
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245579
Pericentric heterochromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.358
DA-40-HO94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527606
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28132
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.35126
BRD-K75506133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53471
BRD-K42757676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19946
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43545
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.84685
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5695
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.577064
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A33119430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30961
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	4.02173
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	5.41545
BRD-K84246050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57276
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.66895
DNA repair	GO Biological Process Annotations 2025	1.0	null
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06111
RBM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12607
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159074
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20447569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75164
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75065750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04097
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04159
BRD-K12879624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68235
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA metabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K17065706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83385
GSE202434,GSE202438_2_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNA damage response	GO Biological Process Annotations 2025	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258272
GSE223334_3_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBAK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65488
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13267677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00213
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27642
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7929
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Seckel syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240092
BRD-K59560948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24262
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC17A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25854
PANK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489727
GB2	DepMap CRISPR Gene Dependency	1.0	9.50412
BRD-K90918886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09816
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.10129
BRD-K77465015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3367
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FECH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525218
PITX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42503