association	dataset	threshold value	standardized value
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00939421
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_6_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
harmine-5855	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91548
Perturb_16822_KD_Miat_SRP379156	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-A18328003_GDC-0980_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NEURL1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00740614
PMC8283158-mmc2.xlsx-TCF4_Glut-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4029
iopromide-6842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00851221
BRD-K13110695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18476
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33227
JUN	ChEA Transcription Factor Targets	1.0	null
GTEX-XV7Q-0526-SM-4BRWR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52673
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MED27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70863
Perturb_7824_KD_EWSR1_SRP106906	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.138
TMEM158	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00865997
monorden-6979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.925991
HF-91-IU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.509896
BRD-A80775386_GR-237_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79090631_CGP-60474_HME1_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF275	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83552
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13801
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36473494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86537
GSE152246_0_v_1_dihydrotestosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04691
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22101
CL34	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52575
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889654
HLCS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560151
BRD-K95858622_NCGC00182609-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4569
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE241875_1_v_0_huwe1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.956534
GRIA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606187
CBX8	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNMC-0226-SM-4DM6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833736
PRKCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5802
GSE164529_0_v_2_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
crotamiton-3050	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
colchicine-630	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ELOF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583925
Lung adenocarcinoma_LUAD_TCGA-78-8662-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2889-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PUS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41601
SW620	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.974089
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.54699
BRD-K11307720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23191
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6410_KD_GLUD1_SRP166295	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYCP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35389
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.375
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PB-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49669041_BX-912_SKBR3_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43281
LY-294002-318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Plasma membrane	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
RNF168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59497
HS616T	CCLE Cell Line Gene Expression Profiles	1.0	1.36366
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4714
Perturb_15539_Mut_Ezh2_SRP220248	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.82123
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.841628
CACNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00912526
BCORL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65478
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8352_KO_ADCY9_SRP320358	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.98489
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17530_KO_TET1_SRP150212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.35883
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46127
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00959
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.9981
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A113-11A-12R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686578
BRD-K05610303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17857
CYP11B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573336
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843812
BRD-K60429174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13102
KCNQ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40428
BRD-K03406345_5-azacytidine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.940036
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PRSS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28828
GSE196407_1_v_0_fluorouracil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.36133
Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45839
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1387
CA5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579912
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLDND1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563843
BRD-K31297909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04592
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
TCF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069205
RDH12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626108
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17040651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06145
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
zona incerta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.898595
GSE84148,GSE96938_0_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.50833
PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15588
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11730256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20838
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551215
ZNF579	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60098
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66855
GSE246195,GSE246305_4_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.517
GTEX-XV7Q-0626-SM-4BRV5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09651
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13491
NPR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546469
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
KAT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16125
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
RELB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00929185
SIPA1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73039
NB10	DepMap CRISPR Gene Dependency	1.0	2.45002
BRD-K13461720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57236
EB2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43171
HS822T	CCLE Cell Line Gene Expression Profiles	1.0	2.4649
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8521
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DUOXA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0074865
PGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00945215
hsa-miR-4766-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
QSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70651
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39539
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16485616_S1122_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11474
vinblastine-7517	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46169
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12357
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33998
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IGFN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00889851
KYAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526759
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30924
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11153
CRCGN015_MCF10A_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03938
pipenzolate bromide-3460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	225.439
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-486-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Perturb_5751_KO_Apoe_SRP115310	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.22319
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14858
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879505
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.925649
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.54279
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INSRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657137
precentral gyrus, right, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925824
GSE248883_0_v_1_shmt2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60968
ASH2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683921
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3871
ncih1650	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34287
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7834-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40045
SDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2366
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00113
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS27A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00869742
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17576
Fat-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	10.0225
BNC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4093
gallbladder	HPA Tissue Gene Expression Profiles	1.0	0.845086
NEK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00740178
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.968848
RAPH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00819781
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10W-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CMK115	DepMap CRISPR Gene Dependency	1.0	4.38904
HOXC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28692
Perturb_2635_KD_TRIM46_SRP323434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.41891
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43538
HS940T	CCLE Cell Line Gene Expression Profiles	1.0	1.41685
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471359
TSEN34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32855
flavoxate-7405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN010_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27823
MAP4K5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563541
GTEX-WRHU-1126-SM-4E3I1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26149
DCUN1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0074909
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880691
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.28342
BRD-K40175214_torin-1_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ERI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.56965
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10640729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31077
PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DGKQ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571395
valproic acid-347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.9149
Melanophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00815
MTF2	ChEA Transcription Factor Targets	1.0	null
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE65617_2_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32191695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25186
MCIDAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48644
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.90607
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59343
CC-70-BD07_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371485
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196699_7_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889654
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81926
phensuximide-3521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTGER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62514
BRD-K88378636_withaferin-a_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	0.9781
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03709
NKAIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48367
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.47047
PIK3R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05113
DYRK1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48869
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC5287225-supp_gr.209163.116_Supplemental_Table_S4.xlsx-Table_S4-Supplemental_Table_S4_Differentially_expressed_genes_related_to_ZNF384-rearranged_ALL_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-520a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38417
Edema	CTD Gene-Disease Associations	1.0	1.11606
CD53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0076752
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97298761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21337
NBN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661896
NLGN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65895
BRD-K76885311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54393
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3348545-NIHMS263168-supplement-3.pdf-149-FOXC1_FOXC1	Rummagene Transcription Factor Associations 2026	1.0	null
DCLRE1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81953
roxarsone-3511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2564
CRCGN012_HEPG2_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69986
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
CSGALNACT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25121
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGFB_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577108
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303801
MDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633846
BRD-K12702054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89104
MDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19672
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15946
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NOX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063985
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64800655_HY-11001_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SDHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00786792
MS4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609722
SLC9A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59097
PRPS1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648353
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCNDBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42455
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HS742T	CCLE Cell Line Gene Expression Profiles	1.0	2.14637
ERBB3_drugactivation_31_GDS4361	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.86109
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_17_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908978
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834711
BRD-K62541003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23716
pimethixene	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24757
JAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16874
IPPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744798
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295462
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5002
FBXO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39741
meclofenamic acid-7038	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280941
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6
PSME3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73374
hsa-miR-4655-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chlortalidone-3198	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIP4K2B	Pathway Commons Protein-Protein Interactions	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58943
AH-23848-6903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TMOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11651
SLC15A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801427
LS 174T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.877995
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30101
TNFAIP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0080197
GSE48812_11_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49925
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918365
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282035
PMC8384902-mmc6.xlsx-DEG_3TF_KD_unique-GeneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T8EM-0426-SM-4DM7E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67737
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831842
GZMK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00695155
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.831891
ARHGAP25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554907
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10761
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82719
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40725
SUZ12-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HTR-8/SVneo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
SERPINF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633792
BRD-K81281620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81134
SPI1	ENCODE Transcription Factor Targets	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38669
HBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34311
GTEX-X4EP-0826-SM-3P5YK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835029
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904872
GTEX-WY7C-2826-SM-3NB3Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09414
PCDHB16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50949
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.2778
ELK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612908
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00604
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.892545
BRD-K09450441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11286
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11531
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.888495
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
increased red blood cell distribution width	MGI Mouse Phenotype Associations 2023	1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LARP4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00715787
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.889108
BRD-A80213327_NSC 23766_HT29_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K91654198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11112
PLA2G4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23469
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A31946439_NCGC00241077-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4349-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14606
CCNT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00879745
SYNGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642053
BRD-K49294207_BIBU 1361 dihydrochloride_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHCHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40937
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL18R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066897
BRD-K21680192_mitoxantrone_BT20_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68199
E2F4	ENCODE Transcription Factor Targets	1.0	null
C8166	DepMap CRISPR Gene Dependency	1.0	4.88317
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XYKS-0426-SM-4BRW4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24559
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22129
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SH2D3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25159
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48955
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.43766
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.8784
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997348
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67096
GTEX-XUJ4-2826-SM-4BOQ2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918524
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3088
Perturb_15282_KD_Kdm4a_SRP223217	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.57682
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.434898
PMC3435504-msb201237-s2.xls-Supp_Table_4a-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
withaferin A-4554	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871311
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2909
PBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66666
bromopride-3617	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GPR143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07136
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35877
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49086
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SM-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A77697958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31169
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66616
KAT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05578
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3665
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3202
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CLDN19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14417
GTEX-UJHI-0226-SM-4IHJL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93409
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00871359
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4153-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19797726-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
IDO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607761
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0323
CDC14A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623275
cuneiform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05732
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.060396
PMC7825356-8844261.f3.docx-13-PROP1_PROP1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964631
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270135
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58472
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68891
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF2-20460467-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12619
Perturb_12861_KO_Clec4d_SRP282597	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.05527
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39093
YD15	DepMap CRISPR Gene Dependency	1.0	2.09226
KIRREL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065411
GSE61117_0_v_1_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363212
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IFNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641881
MXD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0076613
GSE139966_4_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_SOX15_CUT_Tag_top_10k_peaks_Related_to_Figure6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
SUPT7L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572748
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55431
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888298
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	135.285
PMC7833686-mmc5.xlsx-e_q1en30_v1-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29604
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92919
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21778
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0584
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949991
BRD-K48805623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02363
ZNF614	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21334
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_5_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3141
TALDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.86495
BRD-K21025364_NVP-TAE226_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00796915
hsa-miR-4795-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF786	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48806
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE243491_1_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16304302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00479
LNZ308	DepMap CRISPR Gene Dependency	1.0	2.42659
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RN-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40175214_torin-1_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09209
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
EHBP1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725793
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7243-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LCT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497146
liver	HPA Tissue Gene Expression Profiles	1.0	1.82933
PIP4K2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0083573
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07952
WTIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56599
NDUFS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00414805
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.625261
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200392
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.92968
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ANKLE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02011
OCI-LY-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42869
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847291
UBTF	ENCODE Transcription Factor Targets	1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18857
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2238
Perturb_12770_KO_Bin1_SRP201679	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.17905
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
AXIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518668
GTEX-QEG5-1226-SM-447AR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.002
Necrosis	CTD Gene-Disease Associations	1.0	1.73577
SKMM2	DepMap CRISPR Gene Dependency	1.0	2.01413
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2582
CUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50503
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FICD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52566
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824001
MAGEH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85672
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PARP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00380201
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43161
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03867
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A690-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD4-25478319-HGPS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RNF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37225
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17124
quinethazone-4351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.62485
KCNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525182
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85684
Perturb_11764_KO_Irgm1_ERP020504	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76642
DOK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00913741
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18786
Lung squamous cell carcinoma_LUSC_TCGA-56-A4ZJ-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23338
Perturb_15357_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.01906
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29391
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60965
LILRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567032
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.64283
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42599
PHF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41536
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MS4A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00851501
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
RPMI8226	CCLE Cell Line Gene CNV Profiles	1.0	1.39187
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524067
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303422
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960337
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDKN2AIPNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27139
MPP6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCAI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84631
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83603369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15674
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.4461
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02728
GTEX-XQ8I-1326-SM-4BOPV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00886
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10211_KD_TP63_SRP353945	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.16974
ZNF618	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.264
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11529
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSNK2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12549
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
NR2F6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514292
GSE129244_0_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02130563_S1030_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K40260328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17911
GBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22331
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34679
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.936483
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.993409
BRD-K06543683_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ovarian surface epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30777
GTEX-O5YV-1626-SM-2YUNJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877456
B3GAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514561
GSE213219_2_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210580_5_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.7981
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90655
TP53	ChEA Transcription Factor Targets	1.0	null
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SYO1	DepMap CRISPR Gene Dependency	1.0	6.72769
NMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648699
BRD-K50398167_MECLOFENAMATE SODIUM_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	140.11
GTEX-OOBJ-1826-SM-3NB1C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72628
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Conceptus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32156
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_7_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CLPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58101
GTEX-PLZ6-0326-SM-3P61J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19424
NOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00752467
2105_DDX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18615
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.913278
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3444
BRD-A40022950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67123
H3K27me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QESD-1526-SM-2S1QT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04441
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14517
GSE141328_1_v_0_rock2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARHGEF25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576023
RSL1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00439965
MLPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530497
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.972709
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0216
RPS4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60627
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57252
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204006
GTEX-VUSG-0526-SM-4KL22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64949
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967605
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.54877
Perturb_286_KD_GLUD1_SRP308178	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K68548958_C646_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14665
WDR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33564
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.41218
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66665
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60849
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EIF2AK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061966
Perturb_17514_KO_Sh3gl1_SRP315284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.75022
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.68677
BRD-K99749624_S1003_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15026_KD_KLF11_SRP267336	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.30596
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.9781
orlistat-6905	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPCN	CCLE Cell Line Gene CNV Profiles	1.0	1.81169
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T5-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE229698_1_v_2_traf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42184
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07872
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.9781
PRSS53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00956099
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30434
BRD-K92317137_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SEC14L4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00846007
Perturb_6536_KO_Cldn5_SRP305395	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.75137
AGPAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16335
MPP5	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.936143
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
BRD-K27909962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07681
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.227081
BRD-K68143200_-666_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97448
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50139
ARID1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627664
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98189856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54347
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904835
RHOH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503873
SEC31B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25044
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01659
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4600_KO_Mettl3_SRP048598	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10433
BRD-K83783925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51489
BRD-K89107430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13062
GLRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592094
GTEX-QV31-0326-SM-447BM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38463
BRD-K30361950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20225
ornidazole-5483	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DUSP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58673
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MTFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65547
CIITA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85308
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.10284
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B2-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP8B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07823
BRD-K68968009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35416
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.066342
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ODF3L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00903171
SDCCAG8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479814
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02328
MM383	DepMap CRISPR Gene Dependency	1.0	2.21757
BRD-K11008696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73028
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0766
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52332
RNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63489
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.84671
MYLK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00957609
BRD-K01716842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66807
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49122
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8073-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRD5A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00760125
VPS18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633636
GRIN2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774794
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.06225
decitabine_homo sapiens_gpl571_gse29077	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OHPL-0426-SM-3TW8X	GTEx Tissue Sample Gene Expression Profiles	1.0	4.66188
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96053
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.074823
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.69637
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VAX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70224
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ZNF217_ER-Nearest_Ensembl_ZNF217	Rummagene Transcription Factor Associations 2026	1.0	null
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
etodolac-7246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90956468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02859
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80174
PTHLH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00856721
withaferin A-4376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
paclitaxel_homo sapiens_gpl570_gse11550	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
phenyl biguanide-22	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X4XY-0326-SM-46MVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57874
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DD-74-PJ26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.1386
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29235
UBE2NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6385
FOXJ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0075
NCIH2110	DepMap CRISPR Gene Dependency	1.0	4.73294
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2909-03A-01T-0744-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05265
RNF112	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654681
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80865
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CYLD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532282
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265855
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48351
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4885
BRD-K87161673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11465
BRD-K99545815_PF-562271_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE157233_1_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
INADL	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.976039
BACH1	ENCODE Transcription Factor Targets	1.0	null
BRD-K64517075_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	4.45487
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.868
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.19762
ITPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00727363
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
C2orf69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97829
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIX-Logfold_change_threshold_1_0_1_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
PHC1	ChEA Transcription Factor Targets	1.0	null
BRD-K52361779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3006
Activated langerhans cell_Skin_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38539
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC9822887-41598_2022_27261_MOESM10_ESM.xlsx-HCT116_overlap_TCF7L2_CTNNB1_lo-Unnamed_1_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
SNUC5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59906
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.468164
BRD-K74148702_curcumin_HA1E_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K72336314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57516
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superior parietal lobule, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.924069
Frank-Ter Haar syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
BRD-K35128023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58222
BRD-K57282030_JW-7-24-1_MCF7_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MME	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511968
BRD-K49328571_dasatinib_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86488
ATP6V1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16424
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0506
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CD37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512379
DUSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605156
TIMELESS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12313
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF398	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22118
GTEX-S4Z8-0626-SM-4AD6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16272
HCMV_24Hour-anti_EGFR_treatment_20173022_GSE17948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52179
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478935
TRIM32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13128
ATP13A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72391
etilefrine-4590	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.74835
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
D458	DepMap CRISPR Gene Dependency	1.0	2.54663
NIPAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86076
BRD-K76703230_YM-155_VCAP_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876113
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12162
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRSS16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00894583
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3603
KDM5B	ChEA Transcription Factor Targets	1.0	null
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07148
GNG12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00377609
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-85-JR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.889131
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.243
Perturb_9144_KD_METTL3_SRP280216	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.301
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.72354
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
increased red blood cell distribution width	IMPC Knockout Mouse Phenotypes	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268703
CRCGN009_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77587
BRD-K78513633_Lonidamine_A375_24.0_h_177.6_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858167
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUW1-1126-SM-4BONZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933202
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27771
ZNF391	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0088825
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16505
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38701
BRD-K64577478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06898
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.317
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00902002
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.6309
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25805580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11193
pyridoxine-5813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BCL2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565899
MRTFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556972
BRD-A01528713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50396
KCNT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556129
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00131
CCL23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0078805
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ZNF217_ER-Gene_Name_ZNF217	Rummagene Transcription Factor Associations 2026	1.0	null
aminophenazone-6818	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WFON-2526-SM-3LK7P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00919
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84616
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15688_KO_Rel_SRP075924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.45983
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A79768653_sirolimus_HME1_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600242
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MMP23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66683
CADM1	Pathway Commons Protein-Protein Interactions	1.0	null
SREBF1	ChEA Transcription Factor Targets	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74710236_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60316
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AUTS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00930583
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00765999
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30541
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.971024
NAT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606623
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SOCS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460676
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	190.972
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37719063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27377
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68174511_torin-2_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45385
BRD-K03733288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12832
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7539-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LGI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39423
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43523
HLA-E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57875
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11516
HOPX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528672
PMC11071458-media-3.xlsx-literature_genelists-STAT3_targets_brain_Tan_2019_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05393
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49325
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40175214_torin-1_PC3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JAML	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611528
MAST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37231
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	107.203
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8190596-mmc2.xlsx-ETV6_mut-ETV6_mut_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
Ovarian surface epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
ORC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00452099
TRPC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526426
BRD-K93716900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24051
GSE148692,GSE148695_1_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_5_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVJO-0526-SM-447CE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71126
GSE222829,GSE223009_0_v_1_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54914
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.900445
NEK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00423656
BRD-A81879813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02004
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38026
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06706
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3088
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340442
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
LAIR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00857055
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.886758
GTEX-XUYS-0426-SM-47JX3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903123
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873826
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58205
hymecromone-3045	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148692,GSE148695_7_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BSDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99994
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.84166
Perturb_3289_KD_RORC_SRP117629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11251
GSE131161_5_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894944
inferior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23065
BRD-K07035171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4363
BRD-K19139070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5123
Hemorrhage	CTD Gene-Disease Associations	1.0	1.31
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.58112
GTEX-PW2O-0426-SM-48TCC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61704
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858329
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06576
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00882632
PMC11568154-41698_2024_752_MOESM1_ESM.pdf-122-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26838
BRD-K68174511_torin-2_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921316
ATG2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26478
IMMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52515
16498405-TableS10	GeneSigDB Published Gene Signatures	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03054
BRD-K40175214_torin-1_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.79145
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAMK2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87096
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6394-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CASP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681512
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YPEL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95307
TBK1.DF	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882815
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DV-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF767	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70797
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83517
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54144
NR4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801105
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.0791
NB69	DepMap CRISPR Gene Dependency	1.0	3.67536
CARMIL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062657
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.9781
BRD-A33119430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41058
BRD-K57080016_selumetinib_MDAMB231_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-514b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTF3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45707
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCL21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00757971
GTEX-UJMC-0626-SM-4IHJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.67385
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36916
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61972
hsa-miR-1247	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98451611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21779
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336595
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.96224
hsa-miR-4728-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920035
Perturb_17264_KD_Pnldc1_ERP117333	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.60646
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599906
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.92637
SUSD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00835858
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20805
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36295
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_797_KO_Tnfaip3_SRP332632	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
middle frontal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.840103
GSE261563_2_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4703
GSE228181_0_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97081185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01418
TMEM60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89422
LAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00651947
OB-20-LP90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285898
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13475
BRD-K75036062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03686
CFHR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575679
UNC119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536267
SETD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0042376
BRD-K45717258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04059
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.55698
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-V1D1-2626-SM-4JBJH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904193
MMP13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00339354
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.07388
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837399
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
TRIM24_knockout_300_GSE19675	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.75589
BRD-K65932559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4372
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244406
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27205
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	191.558
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129244_0_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-FB60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01621
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00815
NR4A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00860623
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hair-cell stereocilium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.658
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5141
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7914
CBL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530637
CEBPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47669
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08164
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.893598
KM12	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38918
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60558
oxedrine-3578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67868012_PI-103_MDAMB231_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_MYOD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0134
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.570744
BRD-A52530684_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DLST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69802
lithocholic acid-4373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68336408_Tyrphostin AG 1478_HT29_24.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42522
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00226
BRD-K77221872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0778
DLD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43591
BRD-K61717269_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NTMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97162
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A48228341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10495
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.956395
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.5699
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16128
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6325-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
15257931-SuppTableD	GeneSigDB Published Gene Signatures	1.0	null
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54489
BRD-K39692099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45251
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
PLAU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00833608
PANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36006
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.4619
BRD-A19037878_trichostatin A_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GRM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00387202
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01298
BRD-K04930806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33695
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54946
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207787_3_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64483
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889654
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRYBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552773
GSE130081,GSE130082_0_v_10_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Proventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914133
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Phox homologous domain	InterPro Predicted Protein Domain Annotations	1.0	null
CTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44154
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32886
ZBTB42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23663
SP1	JASPAR Predicted Transcription Factor Targets	1.0	null
ChIP_JARID2_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-S341-2026-SM-2XCAA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19756
Perturb_11747_KO_Mek2_SRP321493	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.38296
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
B4GALT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552933
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17678
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
BIRC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.69657
Adrenocortical carcinoma_ACC_TCGA-OR-A5JO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.8465
GRIN2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00498116
inferior temporal gyrus, right, bank of mts	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907117
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29036
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26127
BRD-K55696337_topotecan hcl_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	162.561
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-3_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.825119
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WRHK-1726-SM-3MJFK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915324
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RO-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96735
19843711-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NOP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40077
FAM43B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.451
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HUNS1	DepMap CRISPR Gene Dependency	1.0	14.7485
MPP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04132
CBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00398494
VWA5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81596
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217363_6_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.897032
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452035
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50478
NUAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668611
BRD-K96440230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09222
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73279
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15017
NAPRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67408
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.916144
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
NQO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781676
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYLIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00738795
BRD-A45498368_HY-10044_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89697
LAMTOR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04416
CRCGN012_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00456
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30994
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04682
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880837
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059482
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18155
PMC12486367-Supplementary_Data2.pdf-488-ZNF445_ZNF445	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96688
AGPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52159
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5104-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941919
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23004
GCHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23079
GSE181966_0_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNTB2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78315404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08268
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5973-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP2K4_knockdown_62_GSE19091	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63344
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12323
PCCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41822
BRD-A19248578_L5288-1MG_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A80968824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48838
trichostatin A-6546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03812
RD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6842
BRD-K44012257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25863
GSE228181_0_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPT6-0426-SM-4B672	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961036
BRD-K69932463_AZD8055_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
647V	DepMap CRISPR Gene Dependency	1.0	2.8497
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64890080_BI-2536_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52735829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23401
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.84918
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
U2AF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00737702
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_824_KD_REST_SRP093671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.41205
BRD-K64836560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73986
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
18631401-TableS3	GeneSigDB Published Gene Signatures	1.0	null
MMP28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055733
vestibular nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899448
EZH2	ChEA Transcription Factor Targets	1.0	null
MNDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778873
BRD-A45498368_WYE-125132_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57274378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26102
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
NSUN5P2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68219
TGBC11TKB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58374
Fibrosis	CTD Gene-Disease Associations	1.0	1.18026
ANLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58428
Lung adenocarcinoma_LUAD_TCGA-55-6972-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AP1AR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92057
TEAD4_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6145-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153010_1_v_0_sprr2f_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
nordihydroguaiaretic acid-6182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2355
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
S100A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00800539
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05943
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7421-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFO21	CCLE Cell Line Gene CNV Profiles	1.0	1.92566
PRKAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561535
SLC22A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610027
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07409
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17577
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6862
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13271
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33234
GSE174383_4_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC25A34	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652384
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29257
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.831339
BRD-K77445233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39716
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6976
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851304
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.727629
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C2CD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10494
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.868
lymph node	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A06837695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49825
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15186
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48443
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40891
BRD-K25504083_C8273_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZAP70	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00879923
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TP53-20018659-R1E-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-0.900101
LCMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00906823
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	2.67636
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.03688
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855333
CD34	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059707
GFPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44816
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03164
CBX2	ENCODE Transcription Factor Targets	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661995
BRD-K63500288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2991
RRP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21255
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95759
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49946
GSE161295_2_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1269
GSE185881,GSE185884_2_v_3_ctcf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7268
PRDM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39232
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.85482
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27158
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	14.7429
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12216
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296781
WT1-20215353-NEPHRON PROGENITOR-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SOCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92837
KAT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528951
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449209
AIFM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00683495
Perturb_4583_KO_Socs3_SRP074146	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.3937
ANKRD13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23432
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67918
HSF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25904
GSE114258_3_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174383_2_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20312
GTEX-S4P3-0326-SM-4AD6P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19264
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.020883
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18479
ARF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00441472
LRRN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00718128
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.88386
BRD-K92991072_PAC 1_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00368
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JARID2	ChEA Transcription Factor Targets	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06593056_-666_A375_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.906742
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.937568
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09844
ChIP_SUZ12_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26781
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
SMC1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0112554
hsa-miR-3173-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MMADHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.86918
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
GTEX-X5EB-0008-SM-46MU3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888359
GSE212486,GSE212488_0_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-0426-SM-48U1C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08272
BRD-K02471501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15868
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13423
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941761
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916403
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94623
CLK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00562112
GSE53538_1_v_0_cd2bp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.41589
t62-spleen_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.45777
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26167
CLN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27907
Hepm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98647
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59515
GUCY1A2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02100640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19649
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26453
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QDVN-0226-SM-48TZ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21163
GSE110341_1_v_0_lmna_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COL16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72263
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17863
PDXDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518271
GTEX-WL46-0526-SM-3LK7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12986
Perturb_16419_Mut_Gli2_SRP154383	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.0242
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901502
BRD-K82068522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24606
GSE229973_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARFGAP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658861
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86614
hsa-miR-3180-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.042319
IL2RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051957
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45273
SNUPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00735506
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72379
binding	GO Molecular Function Annotations 2015	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
MAP3K12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567567
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WERIRB1	DepMap CRISPR Gene Dependency	1.0	3.30992
BRD-K30581008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58587
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE210476_9_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.898
hsa-miR-892a	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
PUS7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00817276
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.285462
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.98099
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5460-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
CASP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576209
GSE167404_1_v_0_lama4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.707015
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-LEUTX_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_LEUTX	Rummagene Transcription Factor Associations 2026	1.0	null
ATIC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721879
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58363
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.81396
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6771-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06569345_HG-5-88-01_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08879
CEACAM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00841585
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18187
GTEX-XPT6-0326-SM-4B66V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52716
fenbendazole-3888	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RNF24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532119
TLR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529817
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.950796
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.942808
WNT7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706546
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WASHC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2585
NECTIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706786
PMC3435504-msb201237-s2.xls-Supp_Table_4c-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979312
PPP1R15A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596888
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888805
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98237
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
TRIM69	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533298
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44Q-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84505
doxorubicin_homo sapiens_gpl550_gds846	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52459
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01944
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.10472
PTP4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00941421
CDC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601095
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385534
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14815
Perturb_1137_KO_Tcf3/Tcf4_SRP063508	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.45914
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38779
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-3B-A9HO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1434
Prostate adenocarcinoma_PRAD_TCGA-G9-6498-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52C-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIPC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00835174
BRD-K04546974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03877
PRKAA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00471065
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.656979
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
FGF14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685842
22RV1	DepMap CRISPR Gene Dependency	1.0	6.06325
BRD-K28952606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00248
PCDHB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49937
PDE7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00920095
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8874_OE_TCF21_SRP081577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CCK81	DepMap CRISPR Gene Dependency	1.0	2.35962
BRD-K35625946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0026
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4212256-mmc5.xlsx-FLI1_log2_results-MIR622_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
levocabastine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19692
COLO741	CCLE Cell Line Gene CNV Profiles	1.0	2.74123
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A953-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUGT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00909849
JRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59812
GTEX-P4QS-0426-SM-3NMCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836299
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38931
HAGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81742
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17678
PAX5	ENCODE Transcription Factor Targets	1.0	null
CDK8_knockdown_128_GSE30815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.5926
ARL5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.10822
BBS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690162
canadine-4138	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM45A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538118
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
ALX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43293
PRKAR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00787594
MMP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41682
BRD-K23674935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18585
IRGQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62273
BRD-A17065207_Brefeldin A_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01919
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DUOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065572
ZNF461	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42581
GTEX-OHPK-0426-SM-3MJH3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93656
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0426-SM-3DB91	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901527
PARG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101929
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.09662
ALDH6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678182
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0374
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44203030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23262
MXI1	ENCODE Transcription Factor Targets	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22695
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13637
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894944
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45586
BRD-A31107743_89671_VCAP_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QDVJ-0626-SM-48U1T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85736
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
KDM4D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554452
KRAS.DF.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
LRRC25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608278
BRD-A31107743_89671_OV7_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ALG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32366
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AR	ChEA Transcription Factor Targets	1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904348
hsa-miR-591	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00373476
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APOBEC3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0086545
BRD-K85275903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0937
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	150.517
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82758569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30906
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.426397
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACSL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56063
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97384
BRD-A62025033_temsirolimus [CI779]_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67528
SNX20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546183
Perturb_13829_OE_SETD4_SRP367523	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SF3A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522173
BRD-K20026212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16825
hsa-miR-548p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
Perturb_11576_KO_Zip8_SRP344283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.91064
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21463
UCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17615
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.30583
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904295
Perturb_13492_KD_Ncor1_ERP132013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.775
PSG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103794
BRD-A76941896_Doxorubicin hydrochloride_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AC11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510115
PLOD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00241882
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.60553
sulfamethoxypyridazine-3609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3022822-1471-2164-12-11-S11.XLS-Sheet1-Additional_File_11_SOX2_binding_and_changed_in_gene_expression_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76015448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94213
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26671
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93944
SDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655294
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
TTLL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47942
TTLL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39699
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23077
IFNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470311
FN3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64767
LIMS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492206
CRCGN015_MCF10A_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00695
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEIL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646291
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ANKRD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61263
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0385
IRF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0081777
TNFRSF17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565931
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_26_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4469	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE165579_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hMPV_48Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.53071
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BARHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90133
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31205
SMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32979
blood vessel	GTEx Tissue Gene Expression Profiles	1.0	1.51447
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31332
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G6PC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00951575
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851868
BRD-K45974539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13321
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NPTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33350866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19829
TUBB4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604361
CCDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48782
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36978
ChIP_RNF2_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CD84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00820069
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928459
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE5370	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.16566
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695586
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
BBS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17851
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50205
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98877
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr6_3761906_C_T_b38	GTEx eQTL 2025	1.0	2.62246
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.846985
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS6KB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00421015
PMC8851354-Table_6.xlsx-Ruxolitinib_reg_STAT3-bound-Supplementary_Table_6_Genes_regulated_by_ruxolitinib_that_are_STAT3_targets_in_at_least_two_cell_lines_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7297
Sarcoma_SARC_TCGA-MJ-A68J-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171572_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE152432_1_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6249_KO_Chrna7_SRP338769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ZFP62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46573
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-UC-A7PD-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.14426
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61277
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20675
GTEX-P4PP-1826-SM-2S1NT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864981
BRD-K40175214_torin-1_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CL34	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53068
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
J82	CCLE Cell Line Gene CNV Profiles	1.0	1.45739
BRD-K71808107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16119
GSE218727_2_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.65249
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17551
DFFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00447883
RBPMS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00695352
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.79915
SP140	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650199
nifuroxazide-4835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.56648
CILP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00988784
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50272743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15067
BRD-K26758344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31795
IGF2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00259555
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31515
MATK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28158
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1568
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07435
BRD-K12184916_NVP-BEZ235_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ciprofloxacin-6700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AC-31-PL89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222181
hsa-miR-3690	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE157894_2_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.832653
SPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00374628
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02183
Lung squamous cell carcinoma_LUSC_TCGA-90-7767-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CASP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00411797
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4608010-srep15184-s1.xls-geneSets_HAN_SATB1_TARGETS-HAN_SATB1_TARGETS_UP_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5971
XRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40648
GTEX-WH7G-0626-SM-4LVMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76847
Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21025364_NVP-TAE226_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FAM120A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0513
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_18Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.35263
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165647_5_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	5.25691
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10961
A172	BioGPS Cell Line Gene Expression Profiles	1.0	1.01317
BRD-K61278167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42386
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.741881
ITGB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00886191
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.84079
Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SDK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048164
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K49910674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.84537
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23408
pempidine-2172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39504
SLC47A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0071512
BRD-A79768653_sirolimus_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25912
placenta_6c	HPA Tissue Sample Gene Expression Profiles	1.0	0.859065
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50841342_PAC 1_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11386
RNF138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96814
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97188
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A31107743_89671_SW948_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RRM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00921453
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515221
b220.bcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71405
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
SIGMAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00828733
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80909
SOX2	ChEA Transcription Factor Targets	1.0	null
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF551	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81965
Lung squamous cell carcinoma_LUSC_TCGA-56-7731-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07445
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242002
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7267
Brain Lower Grade Glioma_LGG_TCGA-TM-A84J-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ChIP_RNF2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5O9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anion binding	GO Molecular Function Annotations 2015	1.0	null
PTP4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26814
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43702
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_SMC_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22273
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230018
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.22
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31256
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82483257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03247
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356436
VPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47307
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K40175214_torin-1_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92722247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61295
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80805
BRD-K67561376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01185
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56668
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TDRD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57512
TLNRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37838
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.923823
BRD-K38519585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59353
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RIDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054643
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13505
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.954444
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.879273
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262943
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3973	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04704
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46362
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.0692
RHOQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13042
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AG-0926-SM-48U1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16707
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7832
SKMEL30	DepMap CRISPR Gene Dependency	1.0	3.17275
NRF1	ENCODE Transcription Factor Targets	1.0	null
IL17D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0109006
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9788_KO_Hif1a_ERP133576	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.17417
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFYVE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6671
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LT-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896397
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_13186_Mut_Cry2_SRP303502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.0044
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18047
BRD-K50140147_NVP-TAE684_MCF7_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K85554193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5787
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0113
H2AC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.77508
levocabastine-3509	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HD-19-IW09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327481
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
PAIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71823
Perturb_13103_KO_Immt_SRP404364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE164529_0_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41687
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396911
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64052750_gefitinib_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859531
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0734
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214823,GSE214824_4_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC13138062-mmc7.xlsx-DUGs_E2F1_targets-DUGs_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
COA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0397
BL976 (PLK1)	NURSA Protein Complexes	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OGDHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80116
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85493
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARRDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69579
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K58532728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56928
HDAC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81461
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30682979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33479
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48854
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.4891
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16406336_METHYLENE BLUE_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NB13	DepMap CRISPR Gene Dependency	1.0	3.20365
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVUS-0426-SM-48FE3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976861
OXLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29344
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44100512_KIN001-043_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCNYL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34824
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:I04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4517
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19487
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
PYGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15984
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7547
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25745
MCC13	DepMap CRISPR Gene Dependency	1.0	2.04057
BRD-K40255344_EI-215_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300391
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_2_TBRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885594
GSE242199_6_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954085
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00862
Perturb_4916_KO_TFAP2A_SRP303667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.0259
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GINS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.055
CDC37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45273
Gonadal endothelial cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.87159
RIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581347
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05015
LRP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722406
GSE234334,GSE234336_1_v_0_zhx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PQ-0426-SM-3NMCI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71118
Perturb_3524_KD_TASOR/CNOT1_SRP337789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.61841
TRAF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774165
ASXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23051
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522527
MBD4	ENCODE Transcription Factor Targets	1.0	null
TFPI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047614
CRCGN015_MCF10A.TP53.M_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02754
BRD-A22783572_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QDPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522875
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272898
Hair follicle bulge stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
IRF2BPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09493
epitiostanol-7342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH82	DepMap CRISPR Gene Dependency	1.0	2.7136
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86776
BRD-K08554278_Hoechst  33342 (cell permeable) (BisBenzimide)_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3150a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Super elongation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.083
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38109
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3348
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99127896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00154
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_12195_KD_ERCC4_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LINGO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0077327
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231842
MAP3K10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651652
ASH1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.98871
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931322
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PJ-01A-21R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04798
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A43B-01A-81R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07673
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889654
trichostatin A-1793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02994
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_3_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37786
BRD-K42754852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73233
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SNU175	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80659
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-74-RX30_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205085
trichostatin A-4184	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.848535
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
RYR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615632
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25319
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.850885
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.905524
6533_POLR1A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.64275
GSE172016_2_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.183
deferoxamine-3842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LNCAP	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.970396
GTEX-NFK9-1326-SM-3LK5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68549
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81101
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUDHL6	CCLE Cell Line Gene CNV Profiles	1.0	2.1776
NUDCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17696
C11orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98306
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85245
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.925303
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08388
Lung squamous cell carcinoma_LUSC_TCGA-85-8582-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43992612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12809
HMGCR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602503
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06611347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08712
ITCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31202
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21077
DOCK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681975
BRD-A96536816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64217
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00815
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77024507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9468
Lung adenocarcinoma_LUAD_TCGA-50-5931-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31233830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11211
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891294
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06044
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4W0-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16017
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCIH522	CCLE Cell Line Gene CNV Profiles	1.0	1.59944
antimycin A-2261	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42661
Type 2 diabetes mellitus_Muscle tissue_GSE12643	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.56087
CCL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470176
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68174511_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11906
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04634
inferior frontal gyrus, orbital part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.879849
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21077
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.952333
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06933
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PA-09-IB98_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302637
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.8229
ORAI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609354
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DUSP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79056
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
HS578T	CCLE Cell Line Gene Expression Profiles	1.0	1.38375
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZSWIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49085
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56893290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44952
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CYB5D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96507
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEP43	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528839
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424162
TMC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588596
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991628
CHKA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74909
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03255
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.25525
PMC7397849-supp_gad.338681.120_Supplemental_Table_S1.xlsx-S1L_Shared_genes_3way_overlap-Suppl_Table_S1L_Shared_genes_between_YAP1-MAMLD1_YAP1-FAM118B_YAP1-TFE3_in_vitro_human_samples_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27097
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16123
BRD-A68797623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09613
MPP7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148066,GSE157787_3_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VWDE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81369
GSE188458_2_v_3_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.923545
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1041
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01368
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.947108
COLO320	CCLE Cell Line Gene CNV Profiles	1.0	1.51503
CHD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563949
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11327
GSE155031_6_v_4_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63145939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26289
TAB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558543
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEx Nerve 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-4.23014
MAPK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63748
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU840	DepMap CRISPR Gene Dependency	1.0	3.97238
IHO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575757
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1538
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55542
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22368
SU8686	CCLE Cell Line Gene CNV Profiles	-1.0	-2.01063
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30804
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.46968
SEC24B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76127
SGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80324
BRD-K43389698_BMS-387032_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.893
CRCGN015_MCF10A_48H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04523
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.6338
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06705
GATA2	ChEA Transcription Factor Targets	1.0	null
LIVF001-005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.046
LILRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00793463
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843451
CD248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83733
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8616
Perturb_958_KO_Abca3_SRP116949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.72978
HSPG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626591
KANK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585462
cisplatin_homo sapiens_gpl570_gse23553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE208435_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A764-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-0526-SM-4DXTH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21957
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50478
CD68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95111
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.34295
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98529522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24682
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09655
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
FRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88601
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42794
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE101239_5_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938069
ACTR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57518
KANSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01482
SUZ12	ChEA Transcription Factor Targets	1.0	null
hsa-miR-513c	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB	JASPAR Predicted Transcription Factor Targets	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865595
MMAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526012
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMMY-1026-SM-4DXTI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4559
GRIN3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733651
FLT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433749
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47156
NFE2L2	ChEA Transcription Factor Targets	1.0	null
GSE186124,GSE186128_1_v_0_dnmt3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5805
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
nadolol-4139	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K53281329_SYK-inhibitor_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LAX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504592
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88134
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01739
GTEX-S7SE-0526-SM-2XCD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15495
CSNK2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00367803
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP5PB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568396
GTEX-VUSG-0626-SM-4KL1Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947761
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.658127
PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92632379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5084
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05451
BRD-K07588901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50544
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10158
SART1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00933309
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7579
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12255818-41467_2025_61448_MOESM1_ESM.pdf-51-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
furazolidone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12881
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69692
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60087
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.135
NCIH2066	CCLE Cell Line Gene CNV Profiles	1.0	1.64658
TRAF3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79478
BRD-K89532826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03161
TDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66024
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP1R12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11342
BRD-A76941896_Doxorubicin hydrochloride_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
ORAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14238
RCAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95717
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZM-0326-SM-4DXUJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84087
IARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0002
BRD-K94277689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1732
BRD-K35960502_NICLOSAMIDE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
DPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00857
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23699
GSE138019_1_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95111937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60579
GTEX-PSDG-0826-SM-48TCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12743
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-525-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
torasemide-3517	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72764
TRMT61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00914
PSG8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572694
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288519
GABRA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5047
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCDHB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61382
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04472
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.837374
BRD-A95442017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18215
PIKFYVE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18713
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RZ-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZUMO4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00789267
LRATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82559
BRD-K74879991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06599
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.7053
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OE-78-XD40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30224
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87995
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.50953
BRD-K69350688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2447
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
15604209-Table1a	GeneSigDB Published Gene Signatures	1.0	null
GSE218580_1_v_2_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58341
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_ATF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EJM	CCLE Cell Line Gene CNV Profiles	1.0	1.44421
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24176
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNFRSF11A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505525
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2508
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492903
BRD-K12184916_NVP-BEZ235_MCF10A_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88573743_A443654_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.20492
Brain Lower Grade Glioma_LGG_TCGA-DU-6392-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941761
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE219274,GSE219276_3_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IGFBPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10422
SND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65202
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13732
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AGER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2585
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12476
RETSAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00709912
BRD-K35004659_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K18515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23792
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13137
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.92432
Prostate adenocarcinoma_PRAD_TCGA-KK-A6DY-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
RRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00823838
LRP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92531
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20352
ADRA2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644655
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.965
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
OST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3755
A-Netherlands-602-2009(H1N1)_7Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.60082
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
PLEKHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.94414
DRD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403873
NPTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69603
BW-5147 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.708
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01436
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38171
Lung adenocarcinoma_LUAD_TCGA-93-A4JP-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.22079
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908913
AOC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00781506
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PEMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89616
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419708
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88347
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54895
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381254
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5323
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.923413
Perturb_11723_KO_Eomes_SRP187979	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-A95970093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05528
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7493
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.878046
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K87500884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22042
Lung adenocarcinoma_LUAD_TCGA-44-8120-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNFRSF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585049
OXCT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00325033
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYO9B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522065
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44855
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73562
DOCK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00814201
Perturb_16506_KD_HEPACAM2_SRP257754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.52286
PMC10592962-media-4.xlsx-OC2_genes-gene_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58835676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.291
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52728
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0654
ZFP91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64534
GSE200099_3_v_1_honokiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21939
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27363
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.793
GTEX-S7PM-0426-SM-3NM91	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21232
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24557107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.06515
Perturb_12296_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.48783
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE243491_3_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12525
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.90271
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12927
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23932
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7A-GENE_LIST_UPLOADED_TO_ENRICHR_MLX_TESTES_855_GENES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IL6ST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81258
EZH2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
VAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620412
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07052
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.833613
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PTPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00730396
GTEX-XMK1-2526-SM-4B666	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978642
HS863T	CCLE Cell Line Gene Expression Profiles	1.0	1.54076
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29788
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477005
HCC1806	CCLE Cell Line Gene CNV Profiles	1.0	1.72568
Podocyte_Kidney_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38514
H1_Cell_Line	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.871468
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25434
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4878-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BBS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71638
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946394
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872549
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27342
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MON	DepMap CRISPR Gene Dependency	1.0	5.78588
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus recessus posterioris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.732
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98812
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24378
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K34363599_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9781
CRBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40974
HVCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578024
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00354
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
LE-60-VC29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238525
Perturb_7916_KD_TOP3A/TOP1MT_SRP372079	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.6576
ZCCHC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12693
Fatty Liver	CTD Gene-Disease Associations	1.0	1.41829
OXSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676707
MTHFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512664
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52377
PIGW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83176
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EG-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0417
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.962566
RPUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10643
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931322
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02096
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5979-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.11497
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23841
Perturb_6218_KO_H3f3b_SRP151535	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.96845
ATCAY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25933
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2392
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43403
PDE1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619318
GSE100316_3_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CBY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93607
ChIP_EED_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
IF-31-RN78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340886
ZNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89956
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.26578
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FRS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5715
GTEX-RTLS-0426-SM-2TF5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998182
GSE202434,GSE202438_7_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77834935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42557
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.0451
Lung adenocarcinoma_LUAD_TCGA-91-6849-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82088
AICDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0075844
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-RWSA-0926-SM-47JXW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43445
znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.18172
Lung squamous cell carcinoma_LUSC_TCGA-56-8082-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOMM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40986
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29821
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09304381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19335
MAP3K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00439
CCNF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95201
BRD-K49865102_PD-0325901_MDAMB231_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_5036_KD_Smarcc1_SRP221174	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.29287
Perturb_13216_KO_Dnmt3b_SRP063529	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
chlorcyclizine-3893	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-1237	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54158
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4816-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6454
16574658-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
BE2M17	DepMap CRISPR Gene Dependency	1.0	2.01591
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.25247
hsa-miR-4717-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
PACSIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745115
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19072
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-MV-A51V-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A52510783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26641
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33786
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.848093
Poisoning	CTD Gene-Disease Associations	1.0	1.35328
LPAR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674134
Perturb_10228_KO_Nfat5_SRP337224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.21028
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3552
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.857056
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01459
ALDH5A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684408
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RHOU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633523
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE100316_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM54	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00770851
Perturb_6498_KD_DPY30_SRP341550	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.05931
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974439
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00815
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RAF_UP_V1_UP-Gene_name_ZHX2	Rummagene Transcription Factor Associations 2026	1.0	null
TPCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.185
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06335310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11542
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.45238
SNU1033	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
BRD-K14055576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48533
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14081852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49069
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17242
PMC3022822-1471-2164-12-11-S10.XLS-Suppl_7_newLN229_SOX2_KO_MOCK_2-Unnamed_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137914_0_v_5_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85551
Bladder-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	4.08149
PRADC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35701
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54J-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606458
PKP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00968269
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29656
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895244
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12398
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.915018
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
u266	HPA Cell Line Gene Expression Profiles	-1.0	-1.28527
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.89884
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2575
GATA4-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ULK1_knockout_197_GSE60778	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.12048
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00439968
DGKI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00517013
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13251
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882698
LY-294002-6976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL1RAPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00833069
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74305673_IMD 0354_OV7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.70076
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33221
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43048
CD247	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716969
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LTC4S	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0077042
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82976
MKKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25097
GSE114284_4_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NO10	DepMap CRISPR Gene Dependency	1.0	9.39538
FPGS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480068
SLC25A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538485
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10243
SLC20A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15825
EED-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
WT1	ChEA Transcription Factor Targets	1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.880132
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57821544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.099
SW982	DepMap CRISPR Gene Dependency	1.0	2.53015
PADI4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626559
SUDS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31329
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.612025
DSG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00919013
NDRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63336
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ALCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.662
BRD-K94409042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37687
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55874
19843711-TableS2	GeneSigDB Published Gene Signatures	1.0	null
TREML2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00997501
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872381
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fusiform gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10297
BRD-K32040515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36724
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12589632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12211
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
MARK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425596
BRD-K37331547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33665
VCAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070176
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INKA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643267
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-YB-A89D-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_7_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RHPN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00476777
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.357108
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63436783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1687
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.12416
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K62072978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45851
BRD-K23984367_sorafenib_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN009_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59455
RPL22L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77984
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05831
BRD-K75806288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28267
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.878046
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AAMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84187
ZNF717	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52355
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE226091,GSE226092_3_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3774
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1622
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369015
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.30385
RPP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44798
K562	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.984026
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-06-KB32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.574251
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATG16L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635735
D502MG	DepMap CRISPR Gene Dependency	1.0	2.16369
BRD-K65182930_NVP-AUY922_MCF10A_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
PCNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74889
TEC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00424392
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379708
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30782
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939365
TTC24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630303
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044246
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.1198
GSE176305_0_v_1_rotenone_human	RummaGEO Drug Perturbation Signatures	1.0	null
trichostatin A-5065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DOLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31791
RNF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ5-0426-SM-3P612	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13752
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0734
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.925027
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02519
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42918627_GSK-2126458_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A55594068_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32223
USF1	ENCODE Transcription Factor Targets	1.0	null
macelignan	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0087
CRCGN015_MCF10A_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21659
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894944
STXBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673308
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376728
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18118
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_5_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
INHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63332
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02382
KIF26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1466
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
ABCD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649497
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
VPREB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552348
GSE94849_1_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
M059J	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825565
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9651_KO_TREX1_SRP355094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61661
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
647V	CCLE Cell Line Gene CNV Profiles	1.0	2.10202
RNF2-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20177
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290308
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82577285_DIPROPYLDOPAMINE_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCFD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828083
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.968848
Lung squamous cell carcinoma_LUSC_TCGA-98-A53D-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17549032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76729
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39166
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF283	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91539
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
C84	DepMap CRISPR Gene Dependency	1.0	2.63645
SMCO4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692727
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MM-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
F36P	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46034
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A38030642_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3088
bewo	HPA Cell Line Gene Expression Profiles	1.0	0.945931
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0072
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.20306
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HE-84-SC79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358921
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18793
GTEX-WCDI-0426-SM-4GIAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14493
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20099
medial group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.836171
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NHP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621682
CECR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.925
Perturb_1136_KO_Id3_SRP063508	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.63996
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ITPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00732026
PHACTR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11409
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48403
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.63184
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60325
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68160857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14776
SLC1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00752342
CDKN2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18954
BRD-K17025677_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3572
AATK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713863
Perturb_6605_KO_STK11|KEAP1_ERP124775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.66687
DPEP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517163
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MPZL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466794
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42869
Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE474	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.53662
PRPF38B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62085
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20726
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20197
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.622
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14694
GOLGA6L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68182
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.974075
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91911
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492214
BRD-K32862555_NCGC00183412-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50000283_PHA-767491_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.581482
BRD-K07486034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55606
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29236
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_VCAP_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF655	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68124
Perturb_11494_OE_Tnfsf15_SRP106312	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.39902
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4493	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE161184_0_v_1_tlr7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16189898_CHIR-99021_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYP2C8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00728434
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830085
PDE7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603304
blood	GTEx Tissue Gene Expression Profiles	-1.0	-2.10011
Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_14_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.5994
PRRX2	JASPAR Predicted Transcription Factor Targets	1.0	null
SLC50A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772825
hsa-miR-34c-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207679
PMC7518873-abb0205_Table_S1.xls-TFEB_targets-symbol_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_20_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K35852282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31149
BRD-K80210288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03526
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10909
DDX47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02299
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13787
BRD-K52911425_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL17F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00811588
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44813
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.31244
ATP5F1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48916
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.853574
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48205
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54065
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.122637
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.984136
PROM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90418
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.65273
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.991911
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11864_KO|KD|OE_Trp53/Rb1|Kmt2c|Myc_SRP292755	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RS11846	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.961232
BRD-K73999723_Telmisartan_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.897
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0664
CREM	ChEA Transcription Factor Targets	1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09529
BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19222
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06898
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.17596
GSE149124,GSE149128_3_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72746
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88378636_withaferin-a_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99755021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66923
Perturb_10326_KO_Shp1_SRP370028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.16571
MAPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656829
Bladder Urothelial Carcinoma_BLCA_TCGA-YF-AA3L-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNASE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33372
orciprenaline-4248	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fat_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.91253
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAF_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28351
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41761
Lung squamous cell carcinoma_LUSC_TCGA-77-8130-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8XE-0826-SM-4E3J1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2243
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29604
L3MBTL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578446
hsa-miR-4660	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3447
outer CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2079
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIK3C2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00812078
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22656
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21994
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE85880,GSE85881_4_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SH2D1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488479
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00093
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.950658
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.68185
GSE252958_1_v_0_znf469_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60337657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79138
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
NCIH1568	CCLE Cell Line Gene Expression Profiles	1.0	1.68366
C8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065096
MRPL50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5621
BRD-K14768034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02564
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
CEP55	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00718901
Perturb_7740_KO_Yap_SRP281854	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.7155
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933281
AGK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103198
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.011607
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0875
IDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88101
FXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68729
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SAMHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9993
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YK-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MRPL49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16078
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F3-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154767_2_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10515843-media-1.xlsx-Table_7_Diff_loop_genes_E_v_S-Supplementary_Table_7_Genes_that_involve_significant_differential_looping_in_pediatric_primary_B_cell_CTCF_peaks_compared_to_GM12878_CTCF_peaks_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CA5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561273
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14034
GSE144346_0_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A45498368_WYE-125132_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SFMBT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630735
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.942808
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A110-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZI-1126-SM-3NB1F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49214
ZNF528	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74946
BRD-K44432556_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
17683608-TableS3	GeneSigDB Published Gene Signatures	1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395973
SCD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670691
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537997
IFI44	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.010409
BRD-K99252563_QL-XII-47_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
APOBEC3D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0115547
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19227646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35299
ROBO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514896
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04891
Crohn's disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.317
PHF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13066
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40143
NPW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53963
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215086_0_v_1_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAP2K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18392
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
KNS42	DepMap CRISPR Gene Dependency	1.0	2.08584
Perturb_8046_KD_MCRS1_SRP103083	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.92823
CL11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37562
CYP27B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00970888
PDE6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42972
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45496
ABCC9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0045353
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12541
CAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77648
EP300_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A49447682_DESOXYMETASONE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.599643
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887499
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38035
BRD-K23984367_sorafenib_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325198
PMC10679662-mmc3.xlsx-NC-D3-ZEB2-Mutant-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
15273739-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TK-01A-42R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5417601-pone.0176879.s001.xlsx-Ctrl_vs_UCHL1_KD_result_DEseq_f-id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
VCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88274
SMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98382
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3151
GTEX-OHPL-3026-SM-3MJGS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31666
TRIM28	ChEA Transcription Factor Targets	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02007
APEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68043
NEUROD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00844574
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5148
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GLUD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574363
sulfadoxine-7205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nialamide-3871	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EPB41L2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18000429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00287
GTEX-NFK9-0526-SM-2YUNL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09734
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981698
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08917
BRD-A51777634_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
C9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100098
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.891635
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5524_KO_Trpm7_SRP409200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SUCLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71339
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RI1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47812
molecular_function	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.449
BRAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0085236
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22486
SP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33118
SKRC20	CCLE Cell Line Gene Expression Profiles	1.0	1.49852
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MLX_TESTES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48699175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19842
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PROSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86572
macrophage	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.930236
BRD-K88378636_withaferin-a_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADGRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675168
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9221
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26958
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63912037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86323
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-449a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
reticular nucleus of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11727
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
TE125T	CCLE Cell Line Gene Expression Profiles	1.0	2.23519
PHF8	ChEA Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.79498
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33034
PRDM5	ChEA Transcription Factor Targets	1.0	null
GSE168076,GSE168080_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.90574
bufexamac-5090	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WRHU-1326-SM-4E3K7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88058
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
UGT1A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489657
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95208
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15684
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54463
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.861692
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K87385385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02156
SETD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574645
AP3S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87622
HSDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34264
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-2026-SM-3GADR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20127
PMC11563688-jci-134-173448-s017.xlsx-EC2-gene_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
SUZ12-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
chlorogenic acid-4142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532805
BRD-K47962810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24356
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A43331270_niguldipine hydrochloride_LOVO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ITGAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627905
BRD-K98720112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09607
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	1.42145
FAM76A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73724
C7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00789855
NARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60528
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92569554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87641
BRD-K38350115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5159
IGFBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01027
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70603
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE196699_7_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05913
NECTIN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00974857
COQ10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01904
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0656
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
estradiol_homo sapiens_gpl571_gds4052	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47983010_BX-795_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE139239_3_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295769
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.825609
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNFRSF10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.98354
BRD-K55815187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2379
TUB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55289
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32546
BRD-K12184916_NVP-BEZ235_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26087
Perturb_16953_KO_MLX_SRP183152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.66972
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	146.561
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39571490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63922
ABAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615405
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.616
FSHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581791
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0558
NDC80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607472
TRPV4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0077011
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11532
TAPBPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50104
SUZ12-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45143
Perturb_12771_KO_Bin1_SRP201679	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.82312
PMC7304190-13229_2020_355_MOESM18_ESM.xlsx-Supplemental_Table_5-hNSCs_SATB2_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SO-01B-31R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_JK_LPS-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10187
hsa-miR-3135b	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01731
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78425
DGUOK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645437
IL17RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479332
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11848
monorden-4443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EXOSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90244
trichostatin A-3746	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A464-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A43076080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21619
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.831987
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201264
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SOX6_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429746
VNN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554206
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSC39	DepMap CRISPR Gene Dependency	1.0	2.37529
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62545
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49H-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807475
ZNF772	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53409
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MICAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.03298
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38255
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.03547
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MUC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00462909
BRD-K48545167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02819
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00914921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16662
Perturb_10305_KO_Cxcl12_SRP114370	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.24511
EGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18371
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210744
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63904
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AP3M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34183
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01567962_pyrazolanthrone_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49641
Perineuronal net	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
CCDC85B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18586
Acute Myeloid Leukemia_LAML_TCGA-AB-2887-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.440677
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADSL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00917223
VU-0418942-1	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34786
Perturb_13491_KD_Ncor1_ERP132013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.1774
KCTD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38638
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ODC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664134
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K35978846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89189
procarbazine-3533	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CUL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04219
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69881
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.50874
AXIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.40158
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24792
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12317
SYCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19797
Lung squamous cell carcinoma_LUSC_TCGA-56-8622-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metformin-61	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
red nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0004
Perturb_5013_KO_Sall4_ERP122174	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65994
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01157
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06587
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232713
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.03
Perturb_16609_KO_Larp7_SRP189392	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.11741
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17588
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14237
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52551495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17743
GPBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64898
PMC7529806-41467_2020_18638_MOESM7_ESM.xlsx-Supplementary_Data_4-Supplementary_Data_4_TG_of_EPAS1_EPAS1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
METTL7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95019
BRD-K60870698_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
A2058	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955922
BRD-K16406336_METHYLENE BLUE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
15220918-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-SIU7-0526-SM-3NM8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39535
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292759
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59053
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874819
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SO-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45515
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71006
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GNAO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42551
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PFKFB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636158
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231899
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX10	JASPAR Predicted Transcription Factor Targets	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
DNAAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32494
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A822-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02295
GTEX-XQ3S-0126-SM-4BOO9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988958
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3287_KD_RORA_SRP117629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MRPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11983
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08967
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11033585-BLOOD_BLD-2023-021752-mmc2.xlsx-S10_DGEA_IKZF1-Supplemental_Table_10_Differentially_expressed_genes_between_IKZF1_and_all_other_subcluster_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF667	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9755
PMC8744330-13024_2021_507_MOESM2_ESM.xlsx-Table_S5-Supplementary_Table_5_The_conserved_3-layer_neighborhood_of_TP53_in_the_co-expression_networks_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NHS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573166
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6147-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sulmazole-4127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-4676-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.957214
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47474
IFNA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613598
GTEX-PSDG-1026-SM-48TCV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10787
ZDHHC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74068
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16915
LYZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520929
mRNA_TCF7L2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
buflomedil-4840	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
fluphenazine-3194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11925
hsa-miR-4505	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71062
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.931762
BRCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44454
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.93192
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17597
CCNT2	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955615
GTEX-RTLS-0726-SM-46MV4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876744
GSE134375_0_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JC-0326-SM-4DM5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30851
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92736140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92803
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5176
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00815
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAP1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04074
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	2.49295
BRD-K33997327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3616
BRD-K65361030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24285
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1914
CA14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053248
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14782
MAP2K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30775
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15977
APP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469663
GSE225900_1_v_0_hsdl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDKN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76932
BRD-A27407220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64823
PRRG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00948946
SLC26A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470615
GTEX-S4Z8-0926-SM-4AD6Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14944
hsa-miR-4519	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BT20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87281
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PGK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00749164
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPOCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064917
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLDN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93902
GSU	DepMap CRISPR Gene Dependency	1.0	2.08177
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPRED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00458454
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11362
MVK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488533
CRCGN013_HEPG2_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11115
NCIH1755	DepMap CRISPR Gene Dependency	1.0	3.64466
Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FURIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648125
PXDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13174
GTEX-TMMY-0626-SM-33HBD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863731
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prestwick-967-4833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P78B-0826-SM-3NMCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3183
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50735
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210580_5_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ampyrone-6845	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228472
ACSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16653
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LIN7A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00510912
BRD-K69624346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20431
NME8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00748821
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.798
Perturb_9131_KD_PPP2R2A_ERP121420	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.1549
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73567619_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE203655_0_v_1_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
16288205-GeneTable2	GeneSigDB Published Gene Signatures	1.0	null
TKFC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00747557
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926458
BRD-K41684304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07147
todralazine-5512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15825
CRCGN013_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.59402
PMC10831540-supplementary_table_1.xlsx-DEG_pc-S-EC2-Unnamed_40_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01281780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09647
CYYR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28541
ALYREF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30908
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85658
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629047
BRD-K30214140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51935
GSE200099_2_v_0_honokiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF304	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74218
Lung adenocarcinoma_LUAD_TCGA-44-2665-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_PHC1_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.84269
SLCO6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640734
GTEX-S3XE-0326-SM-4AD6L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14927
NGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0073291
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GB-31-HY20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245146
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01314
NMRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629409
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12362
GBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00692078
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10124
PPP2R5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06812
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A26222320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86869
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM229A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63719
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALG13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646743
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1392
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29211776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01014
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246578
TINF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09194
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49689
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878943
GSE186483_6_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15541
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
F36P	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41951
VLX-600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49468
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8511-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668365
CRCGN015_MCF10A_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58783
Perturb_16739_KO_Gcn5_SRP271119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.83629
GTEX-XUZC-0626-SM-4BOPG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6644
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CBX8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88395026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04819
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.938442
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BPNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47671
JEKO1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67439
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K01039605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1033
BRD-K51295743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17997
BRD-K72501910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75714
ADAM30	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668594
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4885-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96137
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SEMA7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067872
IGDCC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554838
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRSS36	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00891138
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943715
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LK-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52119965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09794
BRD-K45471346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02713
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59267
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DRAXIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67953
ATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51082
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43607
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77703
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.41804
PANX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10941
H3K9me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.317
Lung squamous cell carcinoma_LUSC_TCGA-90-6837-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
tanespimycin-5586	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.853282
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52399
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06419
RICTOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52878
CRCGN016_MCF10A.WT.HP_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15116
Perturb_3563_KD_HMGA1_SRP299065	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.01059
GSTZ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532424
PANX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540809
cloperastine-4271	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05548
EB2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58267
UA-39-TN76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272402
IRF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4221
GSE164874_5_v_1_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.940269
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225383
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SMAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87791
Anemia	CTD Gene-Disease Associations	1.0	1.08868
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646795
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22552
CHD2	ENCODE Transcription Factor Targets	1.0	null
TBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28329
scriptaid-6919	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_11_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B3GNT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61033
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.972285
PERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20447
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.9024
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7329
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78691
BRI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44594
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10831540-supplementary_table_1.xlsx-DEG_pc-S-EC2-pc-S-EC2_Compare_erectile_dysfunction_ECs_vs_normal_ECs_using_either_combined_ED_ED_DM_and_ED_nDM_or_ED_DM_and_ED_nDM_seperately_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
inner CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.876547
CD1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574444
BRD-A89441445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65124
NO-10	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
WT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00456611
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5698-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF220	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57733
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987521
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8413
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99077411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51649
GTEX-XOT4-0426-SM-4B66T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10306
MMP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00765585
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17359
BRD-K70875838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.82096
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83446
LIG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661975
PPARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83096
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EED	ChEA Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.893143
trazodone-7410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_17349_KO_Rora_SRP298165	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.92811
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TTLL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10914
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98441254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46864
CALM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98828
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04641
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86545
Perturb_12860_KO_Clec4d_SRP282597	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.83211
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93335
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206870,GSE206872_4_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07125
Lung squamous cell carcinoma_LUSC_TCGA-56-7822-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYNE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11839
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70J-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7018
BRD-K71758378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35597
TFAP2E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6281
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15482
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.994344
Weight Loss	CTD Gene-Disease Associations	1.0	1.28858
RL7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.956682
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2093
BRD-A99750020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31669
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26871
BRD-K54606188_(+)-JQ1_PC3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42344
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
QPRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00375865
BRD-K00507184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17414
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24373
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3561
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17481
PMC13138062-mmc7.xlsx-DUGs_ESR1_targets-DUGs_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93159873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0487
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6963
GRHL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00760709
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22381
GTEX-RVPV-0226-SM-2TF6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05601
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935123
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70596
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZCCHC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6668
19168792-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830766
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05441
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182180_1_v_2_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UT7	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46648
ZHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04641
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7281-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMPCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00381092
GTEX-OIZH-3026-SM-3NB1G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2763
methotrexate_homo sapiens_gpl570_gse11440	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.801756
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16935435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52134
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96321
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.34009
GPR50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73701
BRD-A03898562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11262
BRD-K32259584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56844
GTF3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38136
KRT17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641345
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.901974
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55691
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887061
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBE	DepMap CRISPR Gene Dependency	1.0	5.18406
BRD-A19633847_PERHEXILINE MALEATE_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4838
ABCC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00876173
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44307
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28665
BRD-K99498722_S1176_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLEC4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0076091
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08291
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TIMM29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48042
Perturb_13104_KO_Opa1_SRP404364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
NCI-H1304	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.248526
BRD-K08109215_I-BET_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.5394
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.125255
Perturb_9099_KD_SSX_SRP128693	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.45317
GTEX-XPT6-0008-SM-4B64Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12034
MCCC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538672
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35936
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44465
levomepromazine-3701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_4425_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.0629
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-A14484404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59436
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7237
proxyphylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34792
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01873
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYL9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496836
SKMM2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.14291
CRCGN014_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54151
HS600T	CCLE Cell Line Gene Expression Profiles	1.0	1.9248
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39796
GSTA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591222
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CFD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598301
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23725
GTEX-XPVG-2926-SM-4B66G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32
ZNF35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95296
17906199-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
TIGD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622881
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885779
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JARID2-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ELF5	ChEA Transcription Factor Targets	1.0	null
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SCN4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584535
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15936
benfluorex-2621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6011-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951773
TCF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2484
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.747908
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
preweaning lethality, incomplete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K78659596_MLN2238_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
placenta_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.26243
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
pontine raphe nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44459
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	0.9781
SLC6A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00462836
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4494	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
MOCOS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054715
MFAP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631175
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943151
BRD-A33711280_Metixene hydrochloride_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896637
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10234
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	0.9781
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ATAD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45877
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.13568
S1PR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006003
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50735
GTEX-OOBK-0425-SM-3LK5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03493
BRD-K28640166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30643
15604209-Table2a	GeneSigDB Published Gene Signatures	1.0	null
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.26843
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VJYA-0226-SM-4KL1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1082
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19357
Perturb_10771_KO_Jnk2_SRP038635	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.64439
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56945
BRD-K92317137_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56861
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
LPXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00990687
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217694_3_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MF-11-EW49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204178
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305719
ATR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561609
BRD-K65182930_NVP-AUY922_MCF10A_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Alzheimer's Disease_CNS - Brain - Hippocampus (MMHCC)_GSE1297	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.61941
BRD-K46015322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10984
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.66463
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.227081
Perturb_15034_KD_WDR5_SRP024294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.50862
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.64136
CRCGN016_MCF10A.TP53.M_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30158
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522918
ZNF226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40627
EVSAT	CCLE Cell Line Gene CNV Profiles	1.0	2.00975
Perturb_15098_KD_PDHA1_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.38797
BRD-K13044802_Ciclopirox ethanolamine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SB-228357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0335
GSE199034_1_v_0_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2817
GORAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04719
GSE228413_4_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hecogenin-7175	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	2.4787
COLO205	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.958434
CEBPD	ENCODE Transcription Factor Targets	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A0TN-01A-21R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28193
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128730_3_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7518873-abb0205_Table_S1.xls-TFEB_targets-ensembl_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A12830281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10251
RIOK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668403
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833321
BRD-K49865102_PD-0325901_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A20477000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76577
BRD-K91197462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95898
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5852-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CNTFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615633
LMAN2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20448
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3853
Perturb_11725_KO_Ikka_SRP229998	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Perturb_2047_KO_Abro1_SRP275730	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.47733
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11767
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63030320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39704
JAZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705646
FBXL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04517
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SCCPDH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641083
DGAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538745
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904101
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15127
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0734
GSE174383_2_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33919
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8569
dacarbazine-6816	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dropropizine-7429	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HSPA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44193
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14993
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KNS62	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9111
Perturb_12529_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
UMPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74739
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.74844
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EIF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00764483
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SAMD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00449542
hydrocortisone_homo sapiens_keloid scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12154
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78K-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01332
Perturb_14365_KD_TIPARP_SRP269034	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.95777
HCC95	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63738
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21361
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71281
BRD-K39503511_MK-0591_A375_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K80482221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08515
DOK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05161
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12461
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	1.0	1.33581
BRD-K44061011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05416
GSE185865_0_v_1_celf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A76941896_Doxorubicin hydrochloride_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.14885
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2176
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49785
POU4F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62541
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832567
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FBXO32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565607
TMEM88	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76724
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65321
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3663-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
fludroxycortide-6039	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC16A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425298
BRD-K31530457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70557
MKRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15339
Perturb_3585_OE_CBFBMYH11_SRP312248	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC3A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571726
CRCGN012_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22008
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF883	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34536
NANOG	ChEA Transcription Factor Targets	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.833613
NTHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19508
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18384
GLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610663
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10792109-NIHMS1929238-supplement-Supplemental_Table_6.xlsx-intersection_genes_up-FOXJ1_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264877
Lung adenocarcinoma_LUAD_TCGA-44-2662-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67435
PDE3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582362
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.402
QE-48-NG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227356
BRD-K12862541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77589
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07753
GSE174383_2_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-42-IC00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257199
BRD-K93875187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07477
NR1H4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61581
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LILRA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00676849
Perturb_3286_KO_E8I_SRP144318	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.27125
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.9847
hsa-miR-376a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K06729289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48557
GSE136233,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1104
SELENOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23882
ESRRG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563309
BRD-K95147502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59987
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.0793
guanethidine-3171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7052_KO_Grk2/Grk5/Grk6_SRP090395	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.62602
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.13582
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49835
BRD-K61934967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72199
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_14655_KD_TCF7L2_SRP050497	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K96459367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1006
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24045
SmoothMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.886016
NUP210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03647
TRPV2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0089918
NRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07055
MRPL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00766743
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.47786
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.175461
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RUNX3	ENCODE Transcription Factor Targets	1.0	null
PTTG1IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.952
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922228
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71005143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35666
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LB-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05378
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00652
Perturb_11197_KD_Pten_SRP311091	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.2681
TMTC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68082
DLG1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917929
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
ENTPD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00716363
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.72443
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17822_KO_Stat1_SRP277338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39206
ISTMES1	CCLE Cell Line Gene CNV Profiles	1.0	1.34851
EXT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00443664
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LH-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41091
NFIC	ENCODE Transcription Factor Targets	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05487
BRD-K53456628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16334
BRD-A15454510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59325
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209533_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516298
ZNF143	ENCODE Transcription Factor Targets	1.0	null
BRD-K55742134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08717
16293578-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.877474
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RUNX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540681
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1737
GAL3ST2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590191
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00269
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05012
BRD-A17448384_beclomethasone_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MTA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551146
GSE101112_0_v_2_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AH-1726-SM-3NB2B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0467
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65291
BRD-K59671190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11057
TRIM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77031
KHM1B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61323
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80415
Liver hepatocellular carcinoma_LIHC_TCGA-BD-A3EP-11A-12R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A8BX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5703-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64746
PMC4608010-srep15184-s1.xls-uniqGenes_UP_DN_Targets-HAN_SATB1_TARGETS_UP_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0734
VPS37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35111
BRD-K94346447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63518
PHC1-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4384
PMC5819186-13040_2018_163_MOESM3_ESM.xlsx-Lung-TCF21_TCF21	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63068307_ZSTK-474_HME1_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TIE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00937571
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXL2NB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20458
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62866
NPFFR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00779129
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46265
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3879
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965362
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RGL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74888
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03567
BRD-K30697463_desoximetasone_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SYNJ2BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35357
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.0692
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF780A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01381
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42184
GATA1-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K02630367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05665
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.147
hsa-miR-455-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCL3L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577431
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487703
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCNM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067447
ZC3H7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72091
primary visual cortex (striate cortex, area V1/17)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0568
RNF2	ChEA Transcription Factor Targets	1.0	null
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-1.28527
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
16093247-Table2	GeneSigDB Published Gene Signatures	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13216
XD-18-IF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205862
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
2-iodomelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32123
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.02802
BRD-K99545815_PF-562271_HME1_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49742819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11136
eldeline-3831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03074
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0426-SM-4IHJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08007
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15825
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.755079
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.886368
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rent1_15448691_hela_lof_human_gpl8300_gds705	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.02743
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17140735_-666_HT29_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
haloperidol-4427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIKE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67664
BRD-K96510191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63485
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03895
BRD-K78965436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65918
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08495
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZK-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZGLP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683417
GTEX-VJWN-0626-SM-3NMAN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890704
M059K	CCLE Cell Line Gene Expression Profiles	1.0	1.51395
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19800225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27083
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.743
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28656917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32392
CCDC74A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67881
BRD-K33951208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99012
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.835648
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CC-20-ZO24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214791
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52763
BRD-K95196255_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCIRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588141
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_468_KD_ADAR2_SRP253895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.64859
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257746
18024211-Webtable1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17104
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56751
PMC10831540-supplementary_table_1.xlsx-DEG_pc-S-EC2-Unnamed_16_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.114
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0581
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901325
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768749
iopanoic acid-3527	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.975504
NCOA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587355
GSE137914_2_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GD-73-ZF64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429975
BRD-K98109987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03085
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.71124
LRP12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673374
SLC20A1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73025859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04747
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834981
PHA-00745360-3907	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDUFC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00698776
prazosin-6315	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86119
BIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05589
PRKCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665428
clotrimazole-3166	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC2814	CCLE Cell Line Gene CNV Profiles	1.0	1.62968
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.88231
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32718
APOC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594152
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MAP3K8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00729333
ACAD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69093
GPR18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00759747
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21422
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.844114
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-BRCA2_156_TCF7_rep1_sorted_peak-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745679
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36529613_P0030_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142588_2_v_3_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2817-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.900892
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80079
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.0433
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.74981
IFITM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44654
lipid binding	GO Molecular Function Annotations 2015	1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNFAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31696
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.850521
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.932436
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6872-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211906
Perturb_7896_KO_NEURL4_SRP336645	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.42083
ZNF723	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18552
PMC3435504-msb201237-s2.xls-Supp_Table_4b-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
SPATA19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00714151
PMC3807112-srep03041-s6.xls-SP1-Gene_Symbol_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76455
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
JARID2-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14828
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10242
GTEX-O5YT-0426-SM-3MJHD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15722
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01561
GTEX-O5YW-0426-SM-3MJHJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26599
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352218
NFATC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00439256
GTEX-UPK5-1526-SM-4JBJA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08368
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98388
VAV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0106436
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
19061838-TableS3	GeneSigDB Published Gene Signatures	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.896492
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRKAR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00688961
EIF2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59208
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55846
Harderian gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
Perturb_17408_KO_Rag2_SRP092590	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.9931
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.1726
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200607
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U412-0526-SM-3DB9I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938701
GTEX-OOBJ-0426-SM-3NB1S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25771
PMC7079160-GCC-59-295-s002.xlsx-15-Supplementary_Table_15_Conserved_IKZF1_target_genes_implicated_in_BCR-ABL1_pre-B_ALL_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
CLTC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36805
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570511
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26534
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
TICAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476008
RANBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04076
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H5-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARD	ChEA Transcription Factor Targets	1.0	null
GSE195743_3_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0113112
BRD-A07407288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44048
BRD-K71935468_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39379715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10054
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2928-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKR1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00416674
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646754
GPRC6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512671
BRD-A06840811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00026
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.3038
SCN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42733
BRD-K68336408_Tyrphostin AG 1478_VCAP_24.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22325
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94999
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877692
BRD-K38227596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75016
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-D1-D3_643_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
vitamin c_mus musculus_gpl1261_gse37676	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SQSTM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00819802
CYB5R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00813593
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91161
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.44984
chlorzoxazone-7456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56891
THADA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00734906
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49108064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01665
NR4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98694
NRBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20808
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DOV13	DepMap CRISPR Gene Dependency	1.0	3.26337
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FOXF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47277
SLAMF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653219
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45R-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCNE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00390149
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.10899
GSE264010_0_v_1_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OCRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630675
HDAC2	ENCODE Transcription Factor Targets	1.0	null
CR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653385
EE-98-PF86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361982
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thymus lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08582
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0938
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZSCAN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31775
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215959
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44633
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4776-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52154207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20332
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15006
IKZF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64067
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	192.958
GSE175787_8_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65813214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22876
RPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.074
Prespliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.638
REG1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647121
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA4	ChEA Transcription Factor Targets	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500586
GTEX-S32W-0526-SM-4AD6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841726
DSCAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762078
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.317
CRCGN015_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05752
GTEX-WHPG-2326-SM-3NMBP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17884
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.6772
BRD-K94243450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40318
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PEX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12123
DTHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00453292
BRD-K09598619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36289
UCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10632
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52316
MRPL47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4514
ZMPSTE24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0245
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39403
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32825
adipose tissue	HPA Tissue Gene Expression Profiles	1.0	0.910649
GUK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00964168
DPPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54405
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NUPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57271
ramifenazone-7233	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40425
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02837
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23803
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RI-11A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1287
CRCGN010_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02345
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13182_Mut_Cry2_SRP303502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.5192
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transverse gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08019
PMC4498179-srep11671-s1.pdf-191-TAL1_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40255344_EI-215_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.023571
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00880522
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NMRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0382
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-1326-SM-2S1O7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885733
BRD-U51024685_HG-6-64-01_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ISL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3227
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16576
WASHC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93155
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33539506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9344
SESN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56921
KCNE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00816145
LAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5308
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE138863_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20585111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06563
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139948_3_v_6_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
WDHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762495
Perturb_1363_KO_NAT10_SRP367833	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.5951
Perturb_16416_Mut_Gli2_SRP154383	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.07669
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-1.28527
BRD-K41717398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13998
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC41A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058188
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.15627
tropine-6147	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OGFOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472829
GPR17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00731323
BRD-K96263742_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Inflammatory bowel disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.317
Hyperplasia	CTD Gene-Disease Associations	1.0	1.30299
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3396-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.03586
LAMP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0112865
P2RX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654831
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
trichostatin A-5882	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TBC1D17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44925
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36443
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905975
TJAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14099
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27334
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86376
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25504083_C8273_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.873745
CRLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81708
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00259
MBIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1744
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18310505-TableS8	GeneSigDB Published Gene Signatures	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86816
Perturb_826_KD_REST_SRP093671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.46412
KLHL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86324
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.054
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.7904
BEX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25916
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29036
TNFRSF18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0126658
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417258
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.074711
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GT-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27481
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.73872
GTEX-U3ZH-0626-SM-4DXT3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44961
GAK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744319
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
middle frontal gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907912
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35429561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04582
BRD-K03816923_Rottlerin_A375_24.0_h_9.68_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51437
RUFY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35245
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MFE280	CCLE Cell Line Gene CNV Profiles	1.0	1.50375
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82868
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-Y737_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225112
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00834203
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28824
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.856778
BAZ1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55682
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17942
AHCTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72601
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83609
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76025
PROK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613334
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
pirenperone-3316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LIFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680085
GSE198165,GSE198166_7_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550432
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02728
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.939513
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.01637
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4612
HMGA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22656
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SPTLC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00450993
Brain Lower Grade Glioma_LGG_TCGA-FG-8191-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5018
HEXIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00861976
PDCD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577368
BRD-K64800655_PHA-793887_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96022
hsa-miR-411	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03292
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QXCU-0226-SM-2TC5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41162
BRD-K72936860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19155
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00634
ROCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606309
BRD-K43389675_DAUNORUBICIN_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NAGLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24471
MON2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66044
FOXO1	ChEA Transcription Factor Targets	1.0	null
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.56616
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225869_1_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982835
Perturb_15251_KO_Ldha_SRP302050	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.1977
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79445
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GPX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496101
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.826685
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904285
MRPL54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30052
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10943
GSE225869_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67473
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830877
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840744
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC32A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655067
BRD-K00877314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74263
IPPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22585
TP53-18474530-U2OS-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
4star	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.09798
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AGXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39581
KYSE410	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38778
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.47132
CRCGN011_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9405
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.267724
IRAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534051
GSE88819_5_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JAK2_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918773
BUB1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540641
KRAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00661885
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chrysin-5505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
caudal group of intralaminar nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18518
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48385
PALS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679005
AG-013608-6395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DNMT3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618885
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K70408591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9736
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39682
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37945
GTEX-R55E-1126-SM-48FDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57523
ChIP_SUZ12_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65182930_NVP-AUY922_A549_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
LS1034	DepMap CRISPR Gene Dependency	1.0	2.9662
BRD-K82662168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26429
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272106
IL7R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00948097
DNAJC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.25803
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K40175214_torin-1_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDFIP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691663
Perturb_7915_KD_TOP3A_SRP372079	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.3687
BRD-K49371609_528116.cdx_HA1E_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGFR_drugactivation_30_GDS4361	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.48293
MLH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45295
Pancreatic adenocarcinoma_PAAD_TCGA-US-A77J-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.1965
TUT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.15192
hsa-miR-376b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Lung squamous cell carcinoma_LUSC_TCGA-98-8020-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12802643-mmc10.xlsx-EC2-EC2_Endothelial_subcluster_2_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5762
chlorambucil-3869	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.88328
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883256
PCGF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03756
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24411
BRD-K06537903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20473
MBOAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20033
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221823
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01009153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44687
STOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64437
SLC5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10898
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07182
UBASH3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00826161
PBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61513
PDXK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589671
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SEMA4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00873077
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1142
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69471644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32226
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15624
OE-78-XD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302584
BRD-K30264389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32819
BJHTERT	CCLE Cell Line Gene Expression Profiles	1.0	1.95892
GGTLC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63979
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GULP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512578
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875778
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17248
LILRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00825705
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RAF_UP_V1_UP-Ensemble_gene_ID_ZHX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56041
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50586
STK17A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587231
placenta	HPA Tissue Protein Expression Profiles	1.0	0.9781
BRD-A31107743_89671_HT29_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LYST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601841
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16426_KD_APP_SRP187586	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.40991
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92018859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01373
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R5-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC39A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00743265
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GARIN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33132
hsa-miR-3919	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-WFON-0526-SM-4LVLY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02396
POLA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575888
MET_knockout_249_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.08643
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dactinomycin_mus musculus_gpl6246_gse21233	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.275
TCF12	ENCODE Transcription Factor Targets	1.0	null
AMIGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07751
ARMCX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59088
BRD-A76528577_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0092
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU869	CCLE Cell Line Gene CNV Profiles	-1.0	-2.64871
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06511
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GOLGA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38285
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
olfactorybulb	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.044
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5417
GTEX-QMRM-0626-SM-447BQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3771
hsa-miR-34a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82485
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8459
MRPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93638
BL7341 (WDFY3)	NURSA Protein Complexes	1.0	null
GSE232631_0_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0275
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.547802
Perturb_16915_KD_Brf1_SRP375944	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.55413
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23363278_CYT997_VCAP_24.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0726-SM-4AD6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894006
CYC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06955
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.57873
RPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00707839
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RNF2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77516
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE146747_0_v_1_nr4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54251
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.858
GTEX-WFG7-0926-SM-4LMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41117
chr6_3919160_T_C_b38	GTEx eQTL 2025	1.0	4.13823
phospholipid binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27276
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5565-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00793226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0531
BRD-K74305673_IMD 0354_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3938_KD_GMDSAS1_SRP378936	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE146070_1_v_0_edem3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864671
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30368
JAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0042368
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35143
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6489
RUNX2	ChEA Transcription Factor Targets	1.0	null
BCS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97164
PTPRZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48038
BRD-K33956247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44243
BRD-K69269694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.01296
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4774-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A36630025_-666_U937_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.0006
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00815
PLA2G2E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542731
Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.996169
Perturb_16766_KO_H1_SRP234772	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210459
MYLK_knockdown_49_GSE14525	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.08347
BRD-K28296557_Akt inhibitor IV_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-1286	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PKNOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01818
MCM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483041
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057463
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.763509
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CFAP126	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90657
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-485-NFE2_NFE2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
bleomycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18349
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphnode	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.871972
SDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486645
preweaning lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
FAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00379526
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_17821_KO_Stat1_SRP277338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K05649647_-666_U937_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NIBAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11975
NSMCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74991
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72612
Perturb_5676_KD_Kdm5b_SRP362502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.10878
Prestwick-1100-3880	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93219845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02427
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.028004
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54850621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36744
GTEX-POMQ-0426-SM-3P61G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03586
ALKBH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593705
Gastric pit	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
GTEX-WFG7-0626-SM-4LMK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09815
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893592
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31995
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5568-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52911425_GDC-0941_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778191
CD274	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639421
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Familial combined hyperlipidaemia_Blood monocyte_GSE11393	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-3.00407
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.887601
Lung adenocarcinoma_LUAD_TCGA-44-6776-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25746333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76298
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40196
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCM6	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19778
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14169
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t70-white-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.56715
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02186
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04697
GSE200099_3_v_0_honokiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-84-CJ21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261048
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.999603
HCC1395	DepMap CRISPR Gene Dependency	1.0	2.02153
PBX1	ChEA Transcription Factor Targets	1.0	null
TRAPPC2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3076
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920447
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30145193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15443
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.832653
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.317
BRD-K37369665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08669
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02159
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
DCLK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514977
Infertility, Male	CTD Gene-Disease Associations	1.0	1.28395
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10124
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989023
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FHL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578081
TNFAIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40982
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.90793
CB-24-FA25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365495
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K24418561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34783
BRD-K05417183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48008
BRD-K53725468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30497
SLC35B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91801
hsa-miR-4297	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5676-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REEP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05389
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE245390_2_v_1_acss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-BRCA1_448_TCF7_rep1_sorted_peak-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
ALG10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44918
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.880739
Perturb_16736_KO_Tug1_SRP176442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.09093
CRCGN016_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56218
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06946
BRD-K49810818_S-8599_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.23296
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51667
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K06166879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21042
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50140147_NVP-TAE684_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894944
BRD-K64509231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20112
BRD-K26863838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25497
ADAMTS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25943
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24933
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GZMH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571252
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Perturb_15311_KD_NFE2L2_SRP339580	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60865
DBNDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73797
BRD-K50946180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04731
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49865102_PD-0325901_MDAMB231_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.12541
Prostate adenocarcinoma_PRAD_TCGA-HC-8262-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
UBOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706868
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.08075
BRD-K85888199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07233
BRD-A81552806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80648
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TE-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15615
SUCLA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652007
HSD17B6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104904
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CXCL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4035
ID4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00834147
BRD-K19894101_MST- 312_PC3_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0426-SM-32PMF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870456
PBX3	ENCODE Transcription Factor Targets	1.0	null
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.890297
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876113
GIMAP8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666201
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.879993
BRD-K24271020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88404
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37044
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202495
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38802
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.975741
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CALU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02228
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.86609
BRD-K30865566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67091
lasalocid-3021	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87909389_F3055_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
placenta_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.00872
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VCP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783927
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26452
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.993634
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18181
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.831202
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0426-SM-4B66A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06673
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3006
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36242
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48555
BRD-K38477985_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4584_KO_Socs3_SRP099234	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.3937
DF-95-CY55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20956
CD-16-KY17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468688
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83957
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.795954
Perturb_3291_KD_RORC_SRP117629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NCIH650	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54757
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.533645
GPATCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533865
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-XAJ8-1226-SM-47JYS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866427
phosphatidylinositol binding	GO Molecular Function Annotations 2015	1.0	null
USP39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44717
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS819T	CCLE Cell Line Gene Expression Profiles	1.0	1.39607
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.9781
RNF181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2071
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARHGEF10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9888
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hsa-miR-3121-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
ZEB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805113
REST	ENCODE Transcription Factor Targets	1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T6MN-1126-SM-4DM71	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27983
BRD-K45498945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49956
CFP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633584
IER5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73072
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
trichostatin A-4458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09525
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Photophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
BRD-K62620616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31771
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83218047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07118
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889654
FOS	ENCODE Transcription Factor Targets	1.0	null
BRD-K20755323_-666_VCAP_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GM1600	BioGPS Cell Line Gene Expression Profiles	1.0	1.2017
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
carteolol-3276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFATC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03076
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379821
SUPM2	CCLE Cell Line Gene CNV Profiles	1.0	1.38872
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053599
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PARD6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94278
GTEX-PWCY-0426-SM-48TCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0206
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V955-0926-SM-4JBJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50271
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837399
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.18118
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996723
MAGED1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622445
GSE87412,GSE92423_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58469385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07743
C11orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37109
CRCGN015_MCF10A.TP53.M_24H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.047
POLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531567
BRD-K71944937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03574
PMC9992472-41467_2023_36735_MOESM5_ESM.xlsx-SOX11_OE_9h_in_SH-EP-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3037
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_baboon_DRSG_lowerRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86027709_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.33464
CRCGN008_HEPG2_24H:I05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3264
NFE2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01562
RABEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46545
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17678
H3K27me3_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.80718
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	0.898278
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31146
BRD-K72636697_QL-X-138_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPFIA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42905
MAP3K6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00793984
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38872
Lymph node	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K80348542_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92144896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48256
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LACTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99515
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A110-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.4317
Placenta	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.01041
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338935
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.749632
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.01739
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.893143
DNA replication preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUIT2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32266
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61154
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01361
BRD-K54118345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0783
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5201
BRD-A28105619_curcubitacin I_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
placenta	HPA Tissue Gene Expression Profiles	1.0	1.06733
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ELF4_ELF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67835515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85959
Brain Lower Grade Glioma_LGG_TCGA-HT-7691-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12197_KD_ERCC6_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.6782
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5405
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5149-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JVM3	DepMap CRISPR Gene Dependency	1.0	2.85807
BRD-K42001678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10172
Perturb_17685_KO_Pgr_SRP365149	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD4	ENCODE Transcription Factor Targets	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931322
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45445
HS571T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7818
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MREG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509563
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41073
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DDAH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663354
OPRD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616699
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MTTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570284
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54471
ATP6V0D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23053
Perturb_5312_KD_PPP3CC_SRP275579	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.43652
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SRM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00858905
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99598
IGSF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00884932
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3835
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.828471
RNASEH2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00960747
H3K27me3_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A69196860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11623
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21031
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ASXL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621242
HDAC11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461815
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
placenta_3a	HPA Tissue Sample Gene Expression Profiles	1.0	0.851778
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TDRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86232
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.16137
TT1TKB	DepMap CRISPR Gene Dependency	1.0	2.68479
CUX1	ChEA Transcription Factor Targets	1.0	null
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01617
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8361
hsa-miR-210	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TOV112D	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74312
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAMKK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575656
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14091
CENPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73286
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648885
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.59742
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222005
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.835648
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18043221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75311
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JK-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NPTN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477311
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223221
RAB3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05566
Perturb_3290_KD_RORC_SRP117629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
liver_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.59609
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206275
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11542
GTEX-OIZG-0426-SM-3LK5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03973
LACC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00789075
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.33116
SP140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35356
GTEX-WZTO-1126-SM-3NM93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07785
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-A76490030_K784-3131_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IFNA14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516439
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.23077
ADGRG5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00795768
PCNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34011
CMPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17269
YH13	CCLE Cell Line Gene CNV Profiles	1.0	1.57785
GTEX-RU72-0008-SM-46MV8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974291
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87494
PBX3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
B2M	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0081016
Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52911425_GDC-0941_LNCAP_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138001_0_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nordihydroguaiaretic acid-1223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
acetylsalicylsalicylic acid-2061	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05653692_DL-PDMP_LOVO_6.0_h_64.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STK26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807405
SNRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501373
BRD-K70978931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13854
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.866354
Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCEAL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589723
FFAR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00848627
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE188870,GSE188871_1_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214823,GSE214824_3_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7613740-EMS124720-supplement-Suppplementary_Tables.xlsx-S6_Immune_evasion_signature-Table_S6_Genes_comprising_IES_displayed_as_RTT_vs_NTT_up_and_downregualted_seperately_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGEF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05506
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211655
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25794
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDCD6IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36578
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.81459
APEH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00748272
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
D425	DepMap CRISPR Gene Dependency	1.0	3.18484
HN	CCLE Cell Line Gene CNV Profiles	-1.0	-2.08447
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88875
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KRT23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054287
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.824347
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5128
BRD-K46056750_AZD-7762_HME1_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-XN-A8T5-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYAT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00784119
BRD-K32522654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55955
MAML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20531
Perturb_7900_KO_FOXM1_SRP345649	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.32666
NDUFB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0071
L33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44427
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3136
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24128
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FZD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0049753
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
AURKAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65028
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IC-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832197
RSBN1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00954541
BRD-K49184477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7612
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834698
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
exisulind-314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K96663576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29213
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.582747
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15581
PIGV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052922
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07445
BRD-A18328003_GDC-0980_MCF10A_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S2.xlsx-S2B_in_vivo_shared-Suppl_Table_S2B_shared_genes_between_RCAS-YAP1-MAMLD1-dR3R1_RCAS-YAP1-FAM118B_RCAS-YAP1-TFE3_in_vivo_tumors_RCAS_mouse_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23992
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5682-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF354C	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12579_KD_SMO_SRP254554	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZNF85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19892
MPDZ	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0826-SM-48FCP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06863
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00861
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858579
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INO80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739266
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247649
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603228
BRD-K58586013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22666
THTPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609117
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02409
BRD-K92991072_PAC 1_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79329532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27865
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17032
PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
CBX2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16419
GTEX-S3XE-0226-SM-4AD6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66548
PSG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0109958
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01558
FOXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09267
BRD-A87137733_GSK-690693_MCF10A_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SEC14L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83054
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Syndromic X-linked intellectual disability Snyder type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28373
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-5745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927516
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
CETP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0127355
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24378
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10521
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.958052
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02287
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04099
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-2826-SM-4KKZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00561
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66895
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54755
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18094
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FNBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47569
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K89744662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40761
IPO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78759
CGAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64727
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K9me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.851379
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54736
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_baboon_DRSG_lowerRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45976
NIPSNAP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85007
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0526-SM-3MJHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10413
GSE115395_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POGLUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35776
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83623
ABHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5093
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QXCU-0926-SM-48FEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40549
Perturb_8480_KD_CSDE1_SRP117243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57916
EM2	CCLE Cell Line Gene CNV Profiles	1.0	2.25454
CCDC97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19469
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-E20_624_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2661-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18149
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TET1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00425668
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32045
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ILF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21798
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.888127
SLAMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575998
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A57474391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14049
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263159
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61628
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54063
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98517
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GUCY1B3	Pathway Commons Protein-Protein Interactions	1.0	null
MME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75507
SH10TC	CCLE Cell Line Gene CNV Profiles	1.0	1.72917
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13653
APPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20511
NCIN87	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3564
GTEX-S95S-0226-SM-4B656	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90815
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4417-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18966
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09790412_EI-195_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9786
GSE152432_6_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-323-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67655
BRD-K21682170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10874
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66541472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73695
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0294
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94015
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.004805
GSE160373_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YBEY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6745
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18774
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54841
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4157
SPG21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05892
spiramycin-3844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_15250_KO_Dnmt3a_SRP386956	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
inner CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994377
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403815
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06378
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PHF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97368
ERP27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514693
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246195,GSE246305_1_v_3_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957062
GSE135514_8_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40175214_torin-1_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RRP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641893
496100421_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14413
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.943062
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32296
Perturb_17425_OE_Gli2a_SRP141427	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39359
Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58153
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15615178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24427
NCIH1092	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44337
Perturb_17348_KO_Rora_SRP298165	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.83792
PLEKHG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06449
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911499
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U4B1-0226-SM-4DXU8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09231
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.72517
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875074
ES-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4487-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06866
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02747732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02976
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.7474
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00994681
SELE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668858
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.864
CRCGN014_HEPG2_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18513
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41814
TAF1	ENCODE Transcription Factor Targets	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305367
EYA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72288
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A4BR-01A-32R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70428675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29278
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19829092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22378
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.286
CHUK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93528
PANX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52951
fat_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.931682
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25082
DOCK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00721097
Heschl's gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02076
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61319
PTOV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46725
PRDM5-23873026-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A5-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58023
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506412
BRD-K81447429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13735
BRD-K27616520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01349
TMEM18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2337
Perturb_3523_KD_TASOR_SRP337789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.54478
gallbladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.03407
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376716
SLC19A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007168
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.41754
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EFNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26796
BRD-A67552019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13934
skmel30	HPA Cell Line Gene Expression Profiles	1.0	0.99207
HSD17B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639406
MS4A6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554807
H2BC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49386
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKBR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52699
BRD-K29415052_NVP-BGT226_A549_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.501702
Perturb_1709_KO_Tox_SRP054249	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.30527
BRD-K18294143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47501
HSPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91325
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1434
BRD-K74148702_curcumin_MCF7_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K41809155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39083
BRD-K72561299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33068
BRD-K42191735_buparlisib_MCF7_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01025
CSNK1G3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046942
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260453
BRD-K79712504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1656
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03363
hsa-miR-186	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
TANK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518011
OVCAR4	CCLE Cell Line Gene Expression Profiles	1.0	1.60645
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LPIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102809
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40175214_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PTAFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518792
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374886
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO201	CCLE Cell Line Gene CNV Profiles	-1.0	-2.85981
Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72636697_QL-X-138_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6870-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NACA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00779961
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52340217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34075
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KM12	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.19297
BRD-K21025364_NVP-TAE226_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53303
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79441
NCIH2029	CCLE Cell Line Gene CNV Profiles	1.0	1.54274
BRD-K50271780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35553
ZFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93053
CHD7	ENCODE Transcription Factor Targets	1.0	null
SIPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09612
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.00325
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98342
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.832653
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10993
ZBTB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88537
SLC30A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636213
BRD-K81463178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90585
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_PanFib_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
PDK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609074
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74762
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.499722
GSE241036_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Intracellular signaling and cell migration supercomplex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37294
GPATCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62383
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4514
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53954
BRD-K86978618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44061
ZDHHC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29469
LIG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68769
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.06179
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08058
SMARCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66486
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S12-ZNF384_DiffExprGene-Unnamed_1_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
16574750-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4892
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.7836
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A57M-01A-51R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	1.0	0.9781
DD-43-WW40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291097
GTEX-VUSG-2426-SM-4KKZG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892831
TRAPPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52696
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897395
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3648
MLLT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09952
BRD-K64665523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17197
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPL53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50691
Prostate adenocarcinoma_PRAD_TCGA-G9-6348-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228785
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65651
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K75985122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05526
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58945
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.55574
BRD-K68174511_torin-2_MCF10A_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL21R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649517
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.01966
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
phenformin-21	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS6KB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00845547
SIAH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460782
MYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42898
496100513_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11659
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45282766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6575
BRD-K59870481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12158
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UE-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69082
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pyramidal layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.92834
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941761
ASRGL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518458
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CADM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00706607
GTEX-XXEK-2426-SM-4BRUS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828953
BRD-K13566078_HY-10518_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8653_KD_DIAPH1_SRP399521	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.24316
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.95569
STAT3	ENCODE Transcription Factor Targets	1.0	null
BRD-K49669041_BX-912_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92434
GTEX-P4PP-0426-SM-3NM9H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55644
GSE210580_0_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76252
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.958052
MACROH2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47862
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326103
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54518
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882127
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58027
TIGD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01599
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
CRCGN008_HEPG2_24H:I03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72685
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C10orf105	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30867
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20147
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARL14EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81153
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K80212510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75489
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83284
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955922
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KCNJ6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00884494
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09523
BRD-K52397688_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
15486232-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
CASK	Pathway Commons Protein-Protein Interactions	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRR19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75418
GTEX-XBED-0726-SM-4GIAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14575
FOS_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.61698
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60891
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22774
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13175
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965317
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4605
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-0426-SM-4AD6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79597
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29178949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19787
BRD-K56928281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19626
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20055
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.58658
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SLC45A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00378295
Perturb_15686_KO_Stat1_SRP277338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30711
VTCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101046
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7025
GTEX-X4XY-0008-SM-46MVL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852907
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2731
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725334
MYOG	ENCODE Transcription Factor Targets	1.0	null
ZNF322	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42377
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RELL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662474
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	1.0	3.17556
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.6181
superficial layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824036
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.872988
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE100102_4_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
VPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04699
OVCAR4	CCLE Cell Line Gene CNV Profiles	1.0	1.69118
GTEX-RUSQ-0326-SM-47JWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46794
BRD-A62184259_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
NFE2L2-20460467-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39580048_arg-a1-2 BRD-K39580048_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12918607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17076
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC2A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82094
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	153.913
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159678_4_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LYSET	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15934
SIN3A	ENCODE Transcription Factor Targets	1.0	null
PMC12358259-Image1.pdf-0-ZNF160_ZNF160	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4520a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SARS-dORF6_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.3042
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC6A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84205
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59335
Acute Myeloid Leukemia_LAML_TCGA-AB-2865-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOLT4	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.964626
BRD-K65438558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54766
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
19139136-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Perturb_16954_KO_MLX_SRP183152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.25451
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
ESPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00622
RAD21	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IL-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09528868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15493
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383325
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.89822
ARNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66439
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224508
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879719
GTEX-OHPM-0426-SM-3TW8V	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0093
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-449b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD4+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.96546
ADH1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631788
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17729
CRCGN014_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07746
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.5821
Perturb_14853_KD_TEAD4_SRP247403	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.09291
SCAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07453
BRD-K73523821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16031
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12406
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.322
Lung squamous cell carcinoma_LUSC_TCGA-22-5491-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.90831
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2697
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.643683
GRB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63242
PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
AADAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23603
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
valproic acid-23	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839102
WNK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00750434
DENR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535286
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.95252
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
15505275-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K31834149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57466
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50252
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.49974
H3K9me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67514
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.85198
HSP90AA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00429999
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
20003503-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4627-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14916_KO_Cd2bp2_SRP034660	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.9631
STK33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613511
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6926
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8185471-mmc6.xlsx-up-_and_downregulated_genes-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_shared_FO_and_FC_regions_respectively_Related_to_Figure_6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
KIF21A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00878819
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4876-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTSH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542659
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965451
SREBP1-19666523-LIVER-FROM-C57BL-MICE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC16A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15034
GNB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00804705
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42869
CCNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668978
BRD-K82585779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34323
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60609
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
t62-spleen_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-2.61688
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1143
SECISBP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37195
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70381
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B1-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46E-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pempidine-3832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.931051
GSE202434,GSE202438_12_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24389
ZNF195	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76544
MACF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53115
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
OXGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617694
NUP50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85684
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2122
CCNQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80697
PMC10055287-media-6.xlsx-intersection_genes_up-FOXJ1_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
NAA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37955
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-192-5p	MiRTarBase microRNA Targets	1.0	null
hydrocortisone_homo sapiens_gpl570_normal scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.06918
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0326-SM-4JBIY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20551
ChIP_SUZ12_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
cingulate gyrus, parietal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26185
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96149826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08505
RTKN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02338
BRD-K07275374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06627
CRCGN014_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3518
GSE193993_4_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3QU-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28652
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.912469
Sarcoma_SARC_TCGA-X6-A8C6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FSTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69918
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMPRSS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00445196
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.896075
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0243
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07997
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PELI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58757
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.90934
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01409
theobromine-2995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIP5KL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643437
GSE174701_5_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.858431
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75005
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56857
RB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561309
ZNF585B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69488
BRD-K14821540_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRIM29	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783745
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NRIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00850276
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.159548
PIFO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66907
GSE188774_1_v_0_hkdc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF168	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00807574
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
USP9X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49979
Perturb_12366_KD_SLC39A7_SRP274341	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12856
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PCSK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09343
Adipocyte	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.08248
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93869
PXYLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07376
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235271
BRD-K76713298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96173
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
ENTPD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22295
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_23_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44964
iPS-20b Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.73305
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5241_KO_Trp53_SRP255362	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
mRNA_ESRRB_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-A11702965_230752_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
15548776-Figure3b	GeneSigDB Published Gene Signatures	1.0	null
tetracaine-7473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4468	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE48812_11_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XXEK-0726-SM-4BRWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77156
HSPB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39826
BRD-K00317371_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K66511507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19778
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73497584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6898
SW954	DepMap CRISPR Gene Dependency	1.0	2.82949
PPP4R3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69155
IDI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663824
Prostate adenocarcinoma_PRAD_TCGA-X4-A8KQ-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68092
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91269812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11918
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MLX_TESTES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77181307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10583
GTEX-Q2AH-0326-SM-48U1K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961579
HES6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24879
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06051
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADAM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24819
INSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30059
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15981
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0734
GTEX-P44H-1026-SM-3NM96	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852962
PMC7217064-IJC-146-3354-s005.xlsx-Table_S6-Supplementary_Table_S6_Genes_significantly_upregulated_in_OC2-transfected_MKN74_cell_compared_to_control_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
PLXNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0076078
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YW-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37335
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201151
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35411
GABPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554741
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28001
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MS4A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637944
BRD-K77281588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90864
KARPAS422	DepMap CRISPR Gene Dependency	1.0	2.9705
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56057
KSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644029
liver	GTEx Tissue Gene Expression Profiles	1.0	1.22092
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02482
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-1.28527
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MANBA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510419
GTEX-SNOS-0326-SM-4DM6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20506
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44006
DPP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057404
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899226
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.236
ZNF525	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39707
PRKAR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433197
RPS6KL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636357
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879385
DMPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23707
BRD-K01371603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44229
postcentral gyrus, right, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0142
GSE211151_2_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61768
Brain Lower Grade Glioma_LGG_TCGA-FG-A70Z-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
mRNA_SOX2_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K85606544_neratinib_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.2605
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36506
LRRC4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575917
EGFR_druginhibition_83_GSE27640	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.93231
AURKA_druginhibition_196_GSE57810	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.13173
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37865854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73274
GSE169205_0_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22729
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-2.06112
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34227
JDP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00638475
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A7U6-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314505
BRD-K59356638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13446
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
doxepin-7415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5451
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.12634
TRAF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619055
SLC22A18AS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00817093
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD4_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LNPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585059
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64246525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14729
JAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549451
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58023
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
fulvestrant-6165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K74116035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78475
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE145430_0_v_1_zmat3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MOB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1121
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10616
CYTH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582819
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43279
GSE174383_1_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TNFRSF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0092945
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4151-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SOX9	ChEA Transcription Factor Targets	1.0	null
SLC6A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00738408
MECP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451756
TRIR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33316
CRCGN008_HEPG2_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7161
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07544
CRCGN015_MCF10A.TP53.M_24H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1675
TSPYL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59389
trichostatin A-2084	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.54189
Perturb_12654_KD_FBXO4_SRP358982	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.0269
MADCAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781602
DALRD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.76292