association dataset threshold value standardized value H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUYS-0126-SM-47JWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.11871 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null regulation of organelle assembly GO Biological Process Annotations 2025 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86124 CRCGN016_MCF10A.TP53.M_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.89426 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.74441 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.870231 EPZ-6438 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 GSE205729,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null CD2AP Pathway Commons Protein-Protein Interactions 1.0 null BRD-K89931949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08537 TP53 ChEA Transcription Factor Targets 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054289 primary motor cortex (area M1, area 4)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.948659 PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568 Rummagene Transcription Factor Associations 2026 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20159 BRD-K64376499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36102 Perturb_16360_OE_Ppargc1a_SRP278337 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BRD-K13229082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02785 Dorsal peduncular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83448 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39192 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_9_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K77965546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06153 KDM5B ENCODE Transcription Factor Targets 1.0 null FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.537582 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35251 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042354 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null early endosome GO Cellular Component Annotations 2015 1.0 null superficial stratum of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06089 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gastric epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.853 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.94551 BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04104 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.979098 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5973-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gtpase regulator activity GO Molecular Function Annotations 2015 1.0 null ventrolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.907929 RPMI8226 DepMap CRISPR Gene Dependency 1.0 2.25079 BRD-K44582497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3211 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.7434 GTEX-WYVS-1626-SM-3NM9R GTEx Tissue Sample Gene Expression Profiles 1.0 0.975184 GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54927 BRD-K80779045 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88887 CEBPZ_02_05 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.64943 GSE210476_2_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE199255,GSE199356_3_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE228727_2_v_1_dapagliflozin_mouse RummaGEO Drug Perturbation Signatures 1.0 null C2orf81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04943 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SP600125 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14081852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11079 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09495 skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 KRAS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00676671 Other source TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.2 PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S4-Supplemental_Table_S4_Genes_commonly_upregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX Rummagene Transcription Factor Associations 2026 1.0 null Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.314 fluphenazine-4461 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DKMG CCLE Cell Line Gene Expression Profiles -1.0 -1.8145 Kidney Diseases CTD Gene-Disease Associations 1.0 1.44273 SR-786 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35731 Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2793-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE225218_8_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Weight Loss CTD Gene-Disease Associations 1.0 1.14438 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MEF2A-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU-DHL-10 COSMIC Cell Line Gene Mutation Profiles 1.0 null STYK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00909287 BRD-K22380647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5909 hsa-miR-4292 TargetScan Predicted Conserved microRNA Targets 1.0 0.241055 HCN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00538123 19286929-SuppTable2f GeneSigDB Published Gene Signatures 1.0 null positive regulation of catalytic activity GO Biological Process Annotations 2015 1.0 null GSE48812_11_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114992,GSE114993_8_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K95537020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2248 primary auditory cortex (core)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.238 GTEX-NPJ7-0011-R5a-SM-33HBK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889766 OC-10-FB51_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.705842 H3K36me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS-53 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.82306 K562_Decitabine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0117605 AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59541 K562_MK-0752_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149335 REEP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09662 KCNK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00834478 Primary somatosensory area, nose, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43095 naproxen-5457 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DHH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00398587 GSE57871_8_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54661 GSE169356_0_v_5_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-UJHI-0126-SM-4IHLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.18634 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.358933 CRCGN011_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94277 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153871_4_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K91243525_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K72843176 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.00962 GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles 1.0 0.836187 TRAF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00660975 BRD-K77273085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32742 Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7442 BICR31 CCLE Cell Line Gene CNV Profiles 1.0 1.62803 DKMG CCLE Cell Line Gene CNV Profiles -1.0 -2.5676 Adrenocortical carcinoma_ACC_TCGA-OR-A5L6-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A Rummagene Transcription Factor Associations 2026 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.94608 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Senior-Loken syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.583 protein transport GO Biological Process Annotations 2015 1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E5-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Np TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.733 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12267 BRD-A12230535_Nutlin-3_NCIH1694_6.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OCRL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00710049 PFDN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86065 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K63809385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51125 GSE157911_1_v_0_hnf4a_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.WT.HP_24H:G11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43012 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-0226-SM-48U1D GTEx Tissue Sample Gene Expression Profiles 1.0 0.896509 BRD-K34232791 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50001 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE160083,GSE160084_2_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null MASTL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544358 GSE218819_3_v_4_kdm5b_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K70533557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39762 A375 COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Tie2 kinase inhibitor_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187961 TIGD3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00785273 clone81 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.465 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GATA1_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K03341571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82921 BRD-K10423475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16082 NOLC1 Pathway Commons Protein-Protein Interactions 1.0 null GSE241108_1_v_0_sulfasalazine_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tonsil TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62255 MARCO LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00707813 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31948 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.09354 ACHN BioGPS Cell Line Gene Expression Profiles 1.0 0.83619 BRD-K52075040_-666_A375_24.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE131798,GSE131804_1_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE114690_1_v_3_tnfsf14_mouse RummaGEO Gene Perturbation Signatures 1.0 null RS4-11 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.32709 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CML - Chronic myeloid leukemia_Haematopoietic stem cell_GSE11889 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.48559 GSE186810,GSE186813_2_v_0_furin_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hs-578-T Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.20523 Lung squamous cell carcinoma_LUSC_TCGA-68-7757-01B-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRSF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00607346 CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Momelotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185316 CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null NIHOVCAR3_OVARY CCLE Cell Line Proteomics 1.0 2.17373 BRD-K33551950_R2146_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A19037878_trichostatin A_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_11594_OE_MYOD1_SRP106379 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.8368 GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 0.830098 GATA1_G1E-ER4_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null flufenamic acid-316 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SARS-CoV MA15_Day2_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.69579 MUC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00537833 LNZTA3WT4 DepMap CRISPR Gene Dependency 1.0 4.03612 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46822 KOPN-8 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.068 rhombomere 10 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29821 BRD-K51849151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28669 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48324 GSE130246_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19574 PCYT1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00633854 BRD-U24835547_GSK1059615_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28284 Perturb_16878_KO_Trrap_SRP198540 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.98821 k562 HPA Cell Line Gene Expression Profiles -1.0 -1.3224 RFC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71087 HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52388 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838745 small intestine HPA Tissue Protein Expression Profiles 1.0 1.42494 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UBLC1 DepMap CRISPR Gene Dependency 1.0 2.80297 Polycythemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.054 HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.01703 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03966 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17578 CRCGN009_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02246 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SA1-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE88819_0_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE201042_2_v_3_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Quercetin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154643 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VAMP5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00618531 Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148010,GSE148120_3_v_2_tet2_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-423 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.03751 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null RAB39A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00949775 known GeneRIF Biological Term Annotations 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.854127 GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977464 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01585 FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135514_2_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null MALME 3M BioGPS Cell Line Gene Expression Profiles -1.0 -0.938093 TAL1_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE74251_2_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A91461229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94612 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PF-3845_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150624 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03224 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050982 CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.64258 considered GeneRIF Biological Term Annotations 1.0 null CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00744507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06708 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.44001 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.918572 K562_Rucaparib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016559 GSE199660_1_v_3_secretin_mouse RummaGEO Drug Perturbation Signatures -1.0 null overnutrition GWASdb SNP-Disease Associations 1.0 0.691672 SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CHERP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.98168 BRD-K60107240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54151 Triclabendazole DeepCoverMOA Drug Mechanisms of Action 1.0 0.32 JAR COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K46985581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07013 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.982164 SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-WHWD-1826-SM-3LK6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.46844 PML ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PILRA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00543398 H3K27ac_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE172490_5_v_3_junb_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K81104218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04881 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null KHNYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33339 c-Fms-IN-3 DeepCoverMOA Drug Mechanisms of Action 1.0 0.32 NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832315 BRD-A58955223_L-sulforophane_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POU5F1-16518401-CHIP-PET-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CORVET complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.02 SP1 ENCODE Transcription Factor Targets 1.0 null BRD-K79347939 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69302 Human - Tonsil - L1 - Naive B HuBMAP Azimuth Cell Type Annotations 1.0 null GSE58724_3_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GATA1_G1E-ER4_mm9_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pinosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.767 posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.839715 POU5F1-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_PHA-680632_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153457 PIM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00716056 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83836 GSE169691_1_v_2_saha_mouse RummaGEO Drug Perturbation Signatures -1.0 null KARPAS-1106P Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.11323 BCL6-25482012-CML-JURL-MK1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40259 Lung adenocarcinoma_LUAD_TCGA-97-A4M1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.30893 CRCGN017_MCF10A.WT.HP_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15072 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24442 STAT3-19079543-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null epithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE150049_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE58724_1_v_4_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956372 Lateral habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12211 SLC24A4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00775684 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52459 GTEX-PWO3-0926-SM-2I5EY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862356 PMC11665559-jciinsight-9-183889-s131.xlsx-Fig2DiffBind_MYB_TR-PLEvsNTC-WT-Gene_Name_MYB Rummagene Transcription Factor Associations 2026 1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283924 SPP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0040085 SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.3152 TC-YIK COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K47052171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07024 BRD-K47349869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.602 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.958442 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16682693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63299 K562_MK-0752_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0193527 NCIH650 CCLE Cell Line Gene CNV Profiles -1.0 -1.33743 AC-05-MR83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341 Perturb_16567_KO_Tra1_SRP251500 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.43764 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13565_OE_Nfia_SRP077282 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 MAZ ENCODE Transcription Factor Targets 1.0 null CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251565 H3K36me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null BRD-K09993756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28549 Cannabis dependence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.86 H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K62511698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30714 ITGA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00596279 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46262 BRD-K33379087_tivantinib_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAB3A_Mutation - D77G point mutation_GDS2482_702_mouse_Cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC6356085__F6 PFOCR Pathway Figure Associations 2024 1.0 null GSE234340_9_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55335 GTEX-Q734-0126-SM-48U1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.16786 RBBP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21922 EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Lomustine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155121 Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUMO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0049673 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.76054 RPS13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16154 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29C-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K19962165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53991 K562_Gandotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141179 positive regulation of hydrolase activity GO Biological Process Annotations 2015 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_AC480_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0134291 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73866 skbr3 HPA Cell Line Gene Expression Profiles 1.0 1.25159 CD1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00656131 periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14133 GSE153871_1_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K74445272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46669 SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WQUQ-0426-SM-3MJFU GTEx Tissue Sample Gene Expression Profiles 1.0 1.08858 GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.875713 GSE206270_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NFK9-1726-SM-3TW8P GTEx Tissue Sample Gene Expression Profiles 1.0 0.983067 TBC1D20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05174 K562_PD173074_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0174805 MAFK_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB Rummagene Transcription Factor Associations 2026 1.0 null layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35468 GTEX-P4QR-0726-SM-2I5GO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69393 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCAM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00840865 naproxen-1706 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47632 TIGD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07124 Perturb_13564_OE_Nfia_SRP077282 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-PLZ6-1126-SM-3P5ZR GTEx Tissue Sample Gene Expression Profiles 1.0 1.47904 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.901352 GTEX-XQ3S-1426-SM-4BOPR GTEx Tissue Sample Gene Expression Profiles 1.0 1.50075 rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.879345 GSE182921_0_v_1_slit2_human RummaGEO Gene Perturbation Signatures -1.0 null ICAM5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00774893 intermediate stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49877 primary motor-sensory cortex (samples)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.920235 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREM JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.91 GSE109140_2_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC3435504-msb201237-s2.xls-Supp_Table_4b-SP1_SP1 Rummagene Transcription Factor Associations 2026 1.0 null nucleus of the stria terminalis, medial division, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04539 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35667 POU5F1-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Secondary motor area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52418 TCFCP2L1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.8962 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_17463_KO_Jun_ERP124420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.61709 GSE205163,GSE205164_5_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-A73965025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11424 TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67830713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28114 GSE140200_1_v_0_trim59_mouse RummaGEO Gene Perturbation Signatures -1.0 null harmol-2900 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null endocytosis GO Biological Process Annotations 2015 1.0 null EWSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07871 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04358 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null FOXA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior cingulate area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32549 ND-15-RC31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.303223 H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SU8686_PANCREAS CCLE Cell Line Proteomics 1.0 6.77553 TARM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00789345 DD-74-PJ26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240931 IFIH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00629752 GTEX-XQ3S-1726-SM-4BOOD GTEx Tissue Sample Gene Expression Profiles 1.0 1.82186 striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03367 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K12886565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49884 dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40167 REST-18959480-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K15099225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68826 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles 1.0 0.887872 BRD-K85909950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12321 K562_GSK-LSD1 2HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0238582 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null mRNA_NANOG_16767105 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null duodenum HPA Tissue Protein Expression Profiles 1.0 1.42494 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-S33H-1826-SM-4AD65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22771 TMEM199 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0087 K562_Alisertib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0210216 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68664 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-1526-SM-4KKZH GTEx Tissue Sample Gene Expression Profiles 1.0 1.23975 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.978967 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.3531 superficial stratum of PCPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42201 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SCC15 CCLE Cell Line Gene CNV Profiles -1.0 -1.39 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ALDH1A3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00454858 HUH6_LIVER CCLE Cell Line Proteomics 1.0 3.76791 PMC3435504-msb201237-s2.xls-Supp_Table_4a-SP1_SP1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7542 Perturb_4239_KO_Ddx5_SRP187042 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.95301 Perturb_16936_KO_Krt19_SRP353487 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.87724 NTERA-2-cl-D1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.55068 GSE77108_4_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Laropiprant DeepCoverMOA Drug Mechanisms of Action -1.0 -0.28 BRD-K30264389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08982 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-XUJ4-2426-SM-4BOO3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02826 Paraventricular hypothalamic nucleus, magnocellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90189 SLC2A4RG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0077087 CRCGN015_MCF10A.WT.HP_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1494 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56477 FAM47E-STBD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544222 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H810 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 GABRA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00464149 Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.16456 VPS72 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23743 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHH6 CCLE Cell Line Gene CNV Profiles -1.0 -1.3887 spiradoline-4553 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SF767 CCLE Cell Line Gene CNV Profiles -1.0 -2.40109 BRD-K89935890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.21727 FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283505 Dmbx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.6103 cellular_component GO Cellular Component Annotations 2015 1.0 null BRD-K53931904 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12491 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14847 hsa-miR-4732-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 FBXO25 Pathway Commons Protein-Protein Interactions 1.0 null IL36RN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00487148 ZNF384 ENCODE Transcription Factor Targets 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34564 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r6 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45571 Perturb_10829_KO_Xbp1_SRP262377 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.53729 MDAMB361 CCLE Cell Line Gene Expression Profiles 1.0 2.25491 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848223 BRD-K33379087_tivantinib_MCF7_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-NL3H-0011-R3a-SM-2I3GL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09479 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04221 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PX-01A-51R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79555018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.488 Nephronophthisis 13 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.715 HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.995341 GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMO2 ChEA Transcription Factor Targets 1.0 null BRD-K81418486_vorinostat_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null liver cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148252_5_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13647 ABCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11343 COLO-680N COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autism spectrum disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.246 guanfacine-2634 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04549 Paraventricular hypothalamic nucleus, descending division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2248 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 0.86895 GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03206 K562_Nilotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0119639 GTEX-PWO3-0011-R3A-SM-2I5EX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878491 regulation of cilium assembly GO Biological Process Annotations 2025 1.0 null DSG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00929169 BRD-K22510845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29093 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null P2RX4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00622795 8793_TCP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.578846 Combined oxidative phosphorylation deficiency 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.257 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-REY6-2126-SM-48FD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.689 H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K22045035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.38972 G361 CCLE Cell Line Gene Expression Profiles -1.0 -1.71419 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intestinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.273 K562_AG-490_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145242 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE252857_1_v_0_klf15_mouse RummaGEO Gene Perturbation Signatures 1.0 null Her2_OE_GSE43730_683_human_MCF10A cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-A51381734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19521 mIMCD-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.649 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.27928 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PSDG-1326-SM-48TD2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.913938 GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50797 Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXO11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00393821 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAGT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00700637 BRD-K43909206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67263 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K09721123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47361 BRD-K52685199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39604 BRD-M30523314_V2264_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7727-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Gastritis DisGeNET Gene-Disease Associations 1.0 null Perturb_10227_KO_Dmnt1_SRP305326 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.54031 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCF7_Resminostat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150904 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Pontocerebellar hypoplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8822 COLO-800 COSMIC Cell Line Gene Mutation Profiles 1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.64401 Sarcoma_SARC_TCGA-DX-A8BN-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null B-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.633 GSE76425_0_v_3_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_symbol_that_KD_acts_upon_AR Rummagene Transcription Factor Associations 2026 1.0 null TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8669-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00536229 regulation of molecular function GO Biological Process Annotations 2015 1.0 null QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346873 CRCGN016_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85869 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21416096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93149 TFF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00716153 10029_ZC3H8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.516493 HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902517 20203266-TableS1b GeneSigDB Published Gene Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K77354492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20827 IFNA17 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00912974 WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231089 MCF7_Resveratrol_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188796 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null disease of metabolism GWASdb SNP-Disease Associations 1.0 0.171149 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4838_OE_Gfi1_SRP220284 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 E2F4-21247883-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.10664 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RAGE_knockout_268_GDS3755 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.45066 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826874 SUM102PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.08066 NOD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00911397 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.280708 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.458 CCRF-SB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.88668 BRD-K72317601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.48979 Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0189 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13514 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041211 Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00042 pempidine-3832 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE142684_4_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE193258,GSE193259_9_v_0_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null NFATC1 ENCODE Transcription Factor Targets 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95688_1_v_0_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.916692 AR4-2J cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.894 CRCGN016_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.96853 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13578_KD_Fem1b_SRP274135 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.05124 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.62991 BRD-K60886324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82785 BRD-K97421379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3753 NFATC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00809781 BRD-K22564762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30551 TCF7L2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8739 TCF7L2_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null cisplatin_homo sapiens_gpl570_gse23553 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mantle zone of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25453 myricetin-4090 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08714 Perturb_3161_OE_Epac1/Pln_SRP053223 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.54521 PRPF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29125 HIVEP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00600294 Perturb_16566_KO_Tra1_SRP251500 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.79632 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 1.94576 FK866 DeepCoverMOA Drug Mechanisms of Action 1.0 0.5 Esophagus - Muscularis GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.7813 BRD-K88282877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.91087 BRD-K88362336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04026 MCF7_Tazemetostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130925 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33546 GPR119 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00564154 r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02228 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.262 intracellular part GO Cellular Component Annotations 2015 1.0 null CXCR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00538692 496100359_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.21008 YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.7076 Lung adenocarcinoma_LUAD_TCGA-55-7725-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE248045,GSE248046_6_v_1_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null macromolecule localization GO Biological Process Annotations 2015 1.0 null CMPK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00593499 BRD-K55187425_ON-01910_MCF7_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE180951_6_v_3_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CD300LD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0070689 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.06798 GSE48812_9_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02661 GTEX-U412-0426-SM-3DB9O GTEx Tissue Sample Gene Expression Profiles 1.0 1.5529 BRD-K03599607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12941 HNF4G_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1568 DepMap CRISPR Gene Dependency 1.0 2.37306 MCF7_Toremifene Citrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180838 CRCGN015_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.51018 GSE235390_4_v_0_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.79104 Brain infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.205 BRD-K12460566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19267 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.74404 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13559_KD_Kdm1a_SRP105108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.04835 KAP1-27257070-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null increased cerebral infarct size MGI Mouse Phenotype Associations 2023 1.0 null hsa-miR-4324 TargetScan Predicted Conserved microRNA Targets 1.0 0.293524 PLCPRF5 DepMap CRISPR Gene Dependency 1.0 2.38057 hsa-miR-3138 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 NB7 DepMap CRISPR Gene Dependency 1.0 2.15558 localization GO Biological Process Annotations 2015 1.0 null GSE135030_3_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null 17389037-Tab6 GeneSigDB Published Gene Signatures 1.0 null FGF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00733876 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.3732 BRD-K70537701 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.37098 BRD-K55465787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99018 BRD-K35964249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18363 GSE176008_0_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 1.35342 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE112763,GSE112767_0_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer CP in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971515 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.88387 USB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00633042 gabexate-7357 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.493 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0061958 DES_KO_GDS4804_171_mouse_young skeletal muscles GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null KNS-62 GDSC Cell Line Gene Expression Profiles -1.0 -1.43086 BRD-K98251998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63583 GTEX-XQ3S-2526-SM-4BOOG GTEx Tissue Sample Gene Expression Profiles 1.0 2.07336 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null IRF4_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22643 GTEX-T6MN-0011-R4A-SM-32QPG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02306 Cervical Cancer DisGeNET Gene-Disease Associations 1.0 null GSE148252_7_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U3ZN-2126-SM-4DXU1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.990651 BRD-K11457257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83747 NSL complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.71 BRD-K39016838 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0144 BRD-K20069402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.25677 H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K09900382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57509 SLC12A6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00554912 MECP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0045299 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K70511574_sunitinib_MCF7_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A15086915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53156 BRD-K91866516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04981 SMARCB1 ENCODE Transcription Factor Targets 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225798 vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 RGL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21804 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.62512 HNF4A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MEF2A-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null GSE233679_6_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null 17676974-TableS2 GeneSigDB Published Gene Signatures 1.0 null MSGN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18361 BRD-K76401790_JNK-IN-5A_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Anterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21004 PANK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0069186 EGLN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00628344 NB-80-IM48_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271631 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25451 Kidney-b cell Tabula Sapiens Gene-Cell Associations 1.0 0.0405488 GAS7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00528401 GSE148695,GSE167281_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null thiocolchicoside-2875 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE135350_3_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.995852 ezetimibe_mus musculus_gpl2995_gse39813 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11791_KO_Crbn_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.53186 obesity GWASdb SNP-Disease Associations 1.0 1.44134 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ca-Ski Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.77914 DOK COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K50941200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48076 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04342 hsa-miR-4487 TargetScan Predicted Conserved microRNA Targets 1.0 0.31417 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CYP2A6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00436476 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.839858 r9 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65453 BRD-K53893978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06315 NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.898381 9478_UBA1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.549522 MS4A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00730328 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37088 9424_TUBG1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.557133 lymphnode BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.45345 CD300LG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0104467 r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13225 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STK155799 DeepCoverMOA Drug Mechanisms of Action 1.0 0.44 OAS3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00766583 H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hydralazine-3724 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.789 mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02001 REST-18959480-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039404 GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23047 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.5866 EMD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00780704 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.50885 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63599 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IPC-298 COSMIC Cell Line Gene Mutation Profiles 1.0 null Anorexia CTD Gene-Disease Associations 1.0 1.02708 MOLM-16 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRIX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00553042 PDE6A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00590154 CRCGN015_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.41897 Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.462954 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPVG-0626-SM-4B65B GTEx Tissue Sample Gene Expression Profiles 1.0 1.08551 HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248344 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Body mass index GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.75229 calycanthine-5744 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MYC-27129775-CHIP-SEQ-CORNEA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21499 Bcl11b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.4632 H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K45734531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.58018 NT5E LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00541051 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4683 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5943 TNFSF14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00788245 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.99641 PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_UPREGULATED_IN_ERGhigh_ERG Rummagene Transcription Factor Associations 2026 1.0 null K562_Carmofur_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.021251 RFXANK NURSA Protein-Protein Interactions 1.0 0.081964 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53627 BRD-K68174511_torin-2_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BST2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00469606 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.24546 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21682 cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null hsa-miR-659 TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 GTEX-S3XE-1726-SM-3K2AM GTEx Tissue Sample Gene Expression Profiles 1.0 1.14654 IL1RAPL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00844811 HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles -1.0 -0.827877 nifuroxazide-2850 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K46439376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17005 Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6097700-pgen.1007515.s008.xlsx-S2_Table-S2_Table_SATB2_Cort_gene-set_list_SATB2 Rummagene Transcription Factor Associations 2026 1.0 null AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.640743 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A5B5-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44567 KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956372 REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Anacetrapib DeepCoverMOA Drug Mechanisms of Action -1.0 -0.3 Roxatidine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 BRD-K52428486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47546 GTEX-OIZI-0426-SM-2XCEF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883181 BRD-K07794261 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46567 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-0126-SM-4DXUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.21913 YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM793B COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36177 MEF2A ChEA Transcription Factor Targets 1.0 null endosomal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.696905 GTEX-OIZH-0126-SM-2HMIS GTEx Tissue Sample Gene Expression Profiles 1.0 1.49503 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045557 RCOR3 ChEA Transcription Factor Targets 1.0 null SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.850822 MOLP8 CCLE Cell Line Gene Expression Profiles -1.0 -1.7262 GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32119 IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17258 SIN3A ENCODE Transcription Factor Targets 1.0 null protein1 GeneRIF Biological Term Annotations 1.0 null CRCGN016_MCF10A.TP53.M_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52493 Perturb_16616_KO_Stra8_SRP274001 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.34834 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05169 RUNX3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00720574 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44055 SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22044 hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50353 r7 part of the basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25016 ZBTB24 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00563965 Acquired metabolic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.202 SW872 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.62283 GSE58724_3_v_4_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null ABCC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556857 DGKD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00490239 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Daphnetin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.012876 Occlusion precerebral artery DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.332 Tonsil BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.18126 AQP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00741359 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ8I-0426-SM-4BOPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.12302 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATP6V1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00696778 BRD-K90571714 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47876 H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_3_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_MC1568_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140854 BRD-K95768123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90811 breast GeneRIF Biological Term Annotations 1.0 null GSE106170_1_v_0_nap1l3_human RummaGEO Gene Perturbation Signatures 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K46001734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12994 CRCGN015_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06972 H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE57871_11_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K27265817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49864 Perturb_10846_KO_Xbp1_SRP197108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.61261 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K19381111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72021 BRD-K35935439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59037 H3K9me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null frontal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13299 BL1797 (BCL11A) NURSA Protein Complexes 1.0 null MDA-MB-330 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.05954 MESOV DepMap CRISPR Gene Dependency 1.0 2.67167 GSE139016_0_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.030606 Orbital area, lateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1235 laminin-4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.647 BRD-K30053194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52977 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22393 GTEX-UTHO-1026-SM-3GAF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.998287 Perturb_13653_KD_CELSR2_SRP149837 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.5745 hsa-miR-3176 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 TSPAN14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0063105 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS620 CCLE Cell Line Gene Expression Profiles 1.0 1.68792 GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 2.14011 BRD-K44760023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.29027 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71666 NELFE ENCODE Transcription Factor Targets 1.0 null BRD-K28339544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27098 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lithocholic acid-4373 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null E2F4 ChEA Transcription Factor Targets 1.0 null GSE193258,GSE193259_9_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null enzalutamide_homo sapiens_gpl570_gse44905 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K32082369 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0862 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K99521908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27063 CRCGN017_MCF10A.TP53.M_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.80396 PDE11A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.011802 STS-0421 COSMIC Cell Line Gene Mutation Profiles 1.0 null SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.050254 KIF5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00504694 subthalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.961531 MCF7_Tucidinostat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175546 BRD-K39979171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03187 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Roxadustat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0214856 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54708 PK1 CCLE Cell Line Gene CNV Profiles -1.0 -1.71919 Perturb_16931_KO_Tmem120a_SRP252965 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.66986 GSE186810,GSE186813_2_v_0_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_Tacedinaline_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016231 BRD-K84792324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.74722 BRD-K06403738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50882 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null rh30 HPA Cell Line Gene Expression Profiles -1.0 -1.91265 GSE174498,GSE174500_5_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180277_0_v_1_bach2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RPL37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33401 OTUD6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7163 MPP-89 GDSC Cell Line Gene Expression Profiles -1.0 -1.73133 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16529 GSE205316,GSE205317_2_v_3_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PRMT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00582682 TCF7L2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17285234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07264 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90047 PMC9290241-13058_2022_1547_MOESM2_ESM.xlsx-Foglio1-Supplementary_Table_S1_Differentially_expressed_transcripts_in_common_between_EPZ-_and_MI-2-treated_MCF-7_cells_MITF Rummagene Transcription Factor Associations 2026 1.0 null GSE137914_0_v_3_tet3_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118794_5_v_1_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Valproic acid sodium salt_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156258 OPRK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00603425 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.3191 GSE114883_0_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null CFH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00694947 Perturb_11781_KO_Apom_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.47675 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.46437 BRD-K64800655_PHA-793887_HCC515_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null transcription GeneRIF Biological Term Annotations 1.0 null BRD-K72060858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11133 Lung adenocarcinoma_LUAD_TCGA-55-8510-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_CEP-33779_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146751 MCF7_SGI-1776 free base_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0119712 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01107 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.886036 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Household income (MTAG) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.869897 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34549 POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20215 TLR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00734037 GTEX-XOTO-0726-SM-4B659 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32751 BICR 10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06213 Asphyxiating thoracic dystrophy 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 BRD-K48459037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79974 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.290316 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08193 GSE187006_3_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Cediranib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0280079 fulvestrant-5598 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13647 RELA_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4271336-13041_2014_88_MOESM6_ESM.xlsx-Genes_in_GENE_CARD_MR_or_ID-Gene_Cards_MR_and_ID_genes_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null COR-L23 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.67347 REST_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.444115 Perturb_13597_KD_Ash1l_SRP133244 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.15694 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43884 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hallucinogen dependence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.859 SNRPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31644 GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41394 CRCGN015_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.07012 Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null a-CCND1 (Ab3) (CCND1) NURSA Protein Complexes 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.421 BRD-K60053695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18468 NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Periciliary membrane compartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.743 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K54507743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02777 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14986 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ING4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556935 GSE178714_6_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null MAMSTR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00581075 GTEX-XGQ4-0126-SM-4AT4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.99703 GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29402 Perturb_4843_OE_Gfi1/Pou4f3/Atoh1_SRP220284 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 14.7617 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06234 ChIP_STAT3_19079543 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562 BioGPS Cell Line Gene Expression Profiles -1.0 -0.838074 Perturb_1348_KD_RAC3_SRP368300 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.98224 BRD-K21671578 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.05052 STAT4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0051796 BRD-K60937893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48098 BRD-K77634326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46991 GSE178714_6_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.47084 BRD-A36630025_-666_MCF7_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.675776 intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 UNC5C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00704584 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MS4A10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00485148 GSE129370_0_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30978 VWA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52803 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03134 CD177 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00586991 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE173394_1_v_0_nfatc2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34184 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K92349794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04904 Taenia tecta, dorsal part, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.347 DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.667982 r6 part of spinal trigeminal nucleus, pars oralis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28339 Perturb_10826_KO_Xbp1_SRP197108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Ciliopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.459 Epithelial Ovarian Cancer DisGeNET Gene-Disease Associations 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916578 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03897 FRAT1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-TML8-1326-SM-4DXTO GTEx Tissue Sample Gene Expression Profiles 1.0 1.13721 Perturb_10799_KO_Xbp1_SRP197108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.80882 Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29218 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94406 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13871 GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures -1.0 null BCLAF1 ENCODE Transcription Factor Targets 1.0 null K562_Disulfiram_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0198714 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null MCM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0543 Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prdm4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.5165 Anterior cingulate area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02275 GATA2 ChEA Transcription Factor Targets 1.0 null GTEX-SNOS-0526-SM-4DM54 GTEx Tissue Sample Gene Expression Profiles 1.0 0.825573 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0226-SM-3NB2G GTEx Tissue Sample Gene Expression Profiles 1.0 0.936831 GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6447 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRAG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00865235 P2RY2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00871662 MCF7_Meprednisone_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131618 Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-O5YW-0126-SM-3LK6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.844672 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 Triple Negative Breast Neoplasms DisGeNET Gene-Disease Associations 1.0 null Perturb_16405_OE_Ppargc1a_SRP173477 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.00688 GSE184892_7_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES Rummagene Transcription Factor Associations 2026 1.0 null LYVE1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0103605 BMF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00693474 GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.30638 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27806 DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.347937 r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47961 KDM5B_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.67934 TAB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00610104 Perturb_16366_OE_DUX4_SRP225205 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.06903 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00894699 Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20274 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HTRA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00561538 GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT DepMap CRISPR Gene Dependency 1.0 7.77089 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null In situ melanoma of skin_Epidermis_GSE4587 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.7234 BRD-K82805160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12396 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K92812209 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21709 LEPR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00689404 GSE209938_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null VPS4A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00506386 Perturb_16925_KO_Hete_SRP220444 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.81614 GTEX-QDVJ-1126-SM-48U1U GTEx Tissue Sample Gene Expression Profiles 1.0 0.859496 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null spleen HPA Tissue Gene Expression Profiles 1.0 1.03968 TKFC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00694941 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.02735 FOXA1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44228 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K12918607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59129 CDON LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00607719 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.837312 EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ7-mel GDSC Cell Line Gene Expression Profiles -1.0 -1.42899 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53476 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.939576 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.89231 BRD-K80700417_SGI-1776_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SMG7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00520302 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25453 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13088 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.95959 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null AKR1C3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00481427 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.7627 EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.937033 RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72646819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.38947 mantle zone of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31031 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null D-247MG COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_2day-MOI-10^4_None_GSE37572 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.63452 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 88.4498 LY-294002-6198 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SRF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5919_STN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.671749 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null conessine-4777 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE77108_8_v_2_saha_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00507 20460173-ImmPortComprehensiveListofImmune-RelatedGenes GeneSigDB Published Gene Signatures 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEF2A ENCODE Transcription Factor Targets 1.0 null GSE173232_4_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Protein quality control and ubiquitin-proteasome system regulation CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null soft tissue HPA Tissue Protein Expression Profiles -1.0 -1.12523 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04122 amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0843 hsa-miR-1915 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957582 H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IFI44 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00707217 DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08109 Meloxicam DeepCoverMOA Drug Mechanisms of Action -1.0 -0.25 GSE208254_3_v_2_irf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240032 CASR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00615636 SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CKM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00856413 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.359545 GSE206502_2_v_1_igf2bp1_human RummaGEO Gene Perturbation Signatures 1.0 null K562_XAV-939_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146521 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140607_0_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-P4PP-1626-SM-2HMJF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23162 H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K82056353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71546 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13673722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04893 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null CMK115 DepMap CRISPR Gene Dependency 1.0 2.34717 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26013 A549_ABT-737_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0135738 dentate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01539 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 0.838008 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54505 BTN2A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544006 BRD-K64640769 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24507 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tofacitinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0120572 Perturb_4379_KD_MALT1_SRP127318 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.04538 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A5KE-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4935 CORL23 DepMap CRISPR Gene Dependency 1.0 2.78034 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE234043_3_v_1_abcb1_human RummaGEO Gene Perturbation Signatures 1.0 null NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRTN3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00703758 GSE121866_0_v_3_six4_human RummaGEO Gene Perturbation Signatures -1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCKIPSD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00644767 H3K4me1_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE130620_1_v_0_kdm4b_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37448 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A6XC-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF168 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00638445 MCF7_MK-5108_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0126613 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PAX5 ENCODE Transcription Factor Targets 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.97603 BRD-K03654379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08281 MDM4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00710965 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-0926-SM-4DXSW GTEx Tissue Sample Gene Expression Profiles 1.0 1.68205 BRD-K50177531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65478 GSE161170,GSE161268_1_v_3_med1_human RummaGEO Gene Perturbation Signatures -1.0 null binding GO Molecular Function Annotations 2015 1.0 null dorsolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.848842 ELF1 ENCODE Transcription Factor Targets 1.0 null H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00719953 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dorsal peduncular area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.09914 GSE102675_3_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Barrett Esophagus DisGeNET Gene-Disease Associations 1.0 null bounding membrane of organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.056889 Perturb_4375_KD_CREBBP_SRP072506 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.23008 SLR20 CCLE Cell Line Gene CNV Profiles 1.0 1.84919 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27178 MCF7_Trametinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0102206 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86244 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55859 Amygdala BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -3.16384 NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.509319 CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.397713 NXPE4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0102197 BRD-K23430114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06224 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152432_1_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NPJ7-0011-R6a-SM-2I3G7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909793 PURA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83251 Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.66696 hsa-miR-558 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 LRF MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K21713052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6332 Perturb_12102_KO_Esr1_SRP132407 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.41833 organic substance transport GO Biological Process Annotations 2015 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null gtpase activator activity GO Molecular Function Annotations 2015 1.0 null NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20472 BRD-K95839423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13639 GSE111138,GSE111149_1_v_0_runx3_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAP4K5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00584699 Femoral artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.026 MTA2 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K68575551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09843 outer CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.918252 RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Perturb_10828_KO_Xbp1_SRP197108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.9558 BRD-K32191695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42482 GSE214212_2_v_1_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07346 BRD-K39484304_triptolide_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SOS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03045 AN3-CA Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.99762 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217552_3_v_4_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02822062_CT-200783_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844375 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_315_OE_Cd4_SRP375640 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HG-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61247793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.62997 epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRKAR2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00588284 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null wortmannin-5603 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null endocrine-cerebro-osteodysplasia syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.205 abnormality of body weight GWASdb SNP-Phenotype Associations 1.0 0.408855 K562_Daphnetin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156766 NOZ DepMap CRISPR Gene Dependency 1.0 4.64921 GSE140651,GSE140653_2_v_0_med1_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_4840_OE_Gfi1/Atoh1_SRP220284 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 A549_Ruxolitinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151867 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K01774461 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49447 GSE231720,GSE231724_3_v_0_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null AM095 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.24 Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84425 Middle cerebral artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.468 RPS6KA3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00506561 posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.88851 GTEX-WH7G-1726-SM-4LVKY GTEx Tissue Sample Gene Expression Profiles 1.0 1.87093 GSE171292_5_v_2_ehhadh_mouse RummaGEO Gene Perturbation Signatures 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_18007_Mut_Card14_SRP260070 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.0116 cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.960798 HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null colchicine-4614 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Thorax TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE207914_5_v_6_nudt7_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MALME3M CCLE Cell Line Gene CNV Profiles -1.0 -1.90883 H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15907 lomustine-7050 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_16938_OE_Prkag1_SRP162537 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.84681 EPB41L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46672 muscle GTEx Tissue Gene Expression Profiles -1.0 -2.03007 BRD-K54622858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16745 CRCGN016_MCF10A.WT.HP_24H:A19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.13818 GTEX-XAJ8-0626-SM-47JY4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.84326 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AKR1B10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00517452 BRD-K24640918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99402 GALNTL5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685936 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04985 Lung adenocarcinoma_LUAD_TCGA-97-A4M7-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fluphenazine-6996 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCHR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00716433 Body fat distribution (trunk fat ratio) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.1 RAB4A Pathway Commons Protein-Protein Interactions 1.0 null NCIH1437_LUNG CCLE Cell Line Proteomics 1.0 2.72032 inner CP in (rostral) midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17317 Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.187 intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38163 GULP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00449871 OVCAR8 CCLE Cell Line Gene Expression Profiles -1.0 -2.00817 GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.929202 GSE153484_2_v_0_foxp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENTPD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0107137 GTEX-P4QS-0926-SM-48TBS GTEx Tissue Sample Gene Expression Profiles 1.0 1.37751 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null basomedial nucleus (accessory basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01491 INPPL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00501105 t56-vastus-lateralis_consensus MoTrPAC Rat Endurance Exercise Training 1.0 3.01758 GSE203362_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Ciliary pocket COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.088 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.06131 PCID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1996 KDM5A ENCODE Transcription Factor Targets 1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.287 K562_Costunolide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0214873 pentetrazol-1408 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles 1.0 0.91243 BRD-K26122955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41757 HDL cholesterol levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AADAT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00632144 outer CP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51763 SAP130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.045 Chagas Disease DisGeNET Gene-Disease Associations 1.0 null r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17047 ondansetron-5796 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45732 male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14662 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-2426-SM-2S1Q4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36921 H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC202 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.13177 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.260802 GSE195743_1_v_4_lhx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Atrophic muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.16 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles 1.0 1.10267 Plasma membrane bounded cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-RM2N-0926-SM-48FD1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.90712 GSE236280_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE213650_3_v_1_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14182 Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95356 Mural cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.948 Perturb_5534_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 18.585 RXRA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE144115_2_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K04363234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15004 NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36771 BRD-K70949282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44338 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050865 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149621_3_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null Breast TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 methoxsalen-3302 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K73969016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11441 ERBB2_druginhibition_8_GDS2139 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.04818 1792_COQ3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.657704 BRD-A68739437_NPK76-II-72-1_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K29745629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6051 HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE118794_0_v_1_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null imipenem-2873 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ACSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08514 GEMIN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43431 bed nucleus of the stria terminalis, medioseptal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06152 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22566 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SNU-16 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.30895 HCC33 CCLE Cell Line Gene Expression Profiles -1.0 -1.93288 GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.906641 YAP1-20516196-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K04257723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.93305 Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84643 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7682 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles 1.0 0.902123 HDAC2_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null C32_SKIN CCLE Cell Line Proteomics 1.0 2.20501 SPI1 ENCODE Transcription Factor Targets 1.0 null Perturb_16486_KO_Thy1_SRP394143 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.25663 CRCGN015_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.70582 HDAC1 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_11_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44588 CD300E LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00545988 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null REST-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZEB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1426-SM-4DXTX GTEx Tissue Sample Gene Expression Profiles 1.0 2.03896 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JVM-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE195568_3_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Autistic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 HUH7 CCLE Cell Line Gene Expression Profiles -1.0 -1.48146 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.36557 CERS6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00560698 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02766 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13929 GCSAML LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0047968 K562_Celecoxib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0255469 posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.89495 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null outer CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08662 K562_Divalproex Sodium_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0208467 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K47508820 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84959 A549_MLN8054_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143308 dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.81417 496100324_FWM_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.52713 IL4R LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00504811 GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55588 KYSE-150 GDSC Cell Line Gene Expression Profiles -1.0 -1.53856 NOBOX LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0052384 K562_AG-490_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167325 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null BRD-K70978931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86915 BRD-A98203122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51722 GSE154464_1_v_2_cdk6_mouse RummaGEO Gene Perturbation Signatures 1.0 null APOL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35958 SAP30 ENCODE Transcription Factor Targets 1.0 null BRD-K92565319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46417 Anterior cingulate area, dorsal part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39497 superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11694 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00205 Psychotic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.121 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71542 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42555 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null prostate_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.936037 BRD-K28601178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22529 DMB DeepCoverMOA Drug Mechanisms of Action -1.0 -0.35 BRD-K84939696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20755 Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 BRD-K11782435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46665 TM31 CCLE Cell Line Gene Expression Profiles -1.0 -1.54648 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null Nr1h3::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.6036 GSE106661,GSE106665_0_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null 639-V COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE109530,GSE109531_2_v_3_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null YA-78-MS95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252624 Intraciliary transport particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.151 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SDHA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0060886 SIRPA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0077069 KAT2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TNP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04713 nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SU-DHL-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null butacaine-5748 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SEMA4F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47582 organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null BAG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15176 mRNA_TCF3_20139965 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null SK-GT-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.22672 interleukin-27 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.348 A549_Capecitabine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0117998 YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K11566857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43705 PSRC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00363437 GTEX-R55D-1826-SM-48FEF GTEx Tissue Sample Gene Expression Profiles 1.0 1.01817 GSE101537_1_v_3_neurog3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE220942_2_v_1_galnt7_human RummaGEO Gene Perturbation Signatures -1.0 null primary auditory cortex (core)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.968338 SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02297 caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.840784 A172 BioGPS Cell Line Gene Expression Profiles 1.0 0.831366 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null Internal carotid artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.015 INO80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5371 PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XOTO-0126-SM-4B66N GTEx Tissue Sample Gene Expression Profiles 1.0 1.29968 USP19 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00381262 BRD-K78647367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11579 Membranous Glomerulonephritis DisGeNET Gene-Disease Associations 1.0 null KYM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.66698 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.054 GTEX-S3XE-0626-SM-4AD6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.78682 RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_3_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null Taenia tecta, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93104 GA-87-BR97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.325385 KYSE-50 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.35683 1941_CTPS1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.579767 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 inner SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34288 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IL-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null intermediate stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08316 TE4 CCLE Cell Line Gene CNV Profiles 1.0 2.22155 TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18835 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33231 GTEX-NL3H-0011-R6a-SM-2I3G8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4759 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ERG_ERG Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02432 H3K4me1_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.44355 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE150895,GSE150896_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1015 periventricular stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06152 MDAPCA2B CCLE Cell Line Gene Expression Profiles 1.0 2.03606 GSE135400_1_v_0_kdm1b_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF684 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.9525 GATA1_G1E-ER4_mm9_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.984815 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04342 BEN GDSC Cell Line Gene Expression Profiles 1.0 1.77218 tonzonium bromide-6457 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-NPJ7-0011-R10A-SM-2I3E5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941476 BRD-K98276754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28035 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EFE184 CCLE Cell Line Gene CNV Profiles 1.0 1.75519 RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CD1E LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00741073 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.421655 GSE193624_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null fluoxetine_mus musculus_gpl1261_gse35761 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09688 mcf7 HPA Cell Line Gene Expression Profiles 1.0 1.23495 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.85133 BRD-K10317744 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46214 r3 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23873 STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinoma Of Lung DisGeNET Gene-Disease Associations 1.0 null Cardiomyoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.676 ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01083 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZEB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18059 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03193 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79592 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETS1_ETS1 Rummagene Transcription Factor Associations 2026 1.0 null GSE168401_2_v_0_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null 16728581-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.89537 LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null marker GeneRIF Biological Term Annotations 1.0 null BMX LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00836318 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09741 spleen_3a HPA Tissue Sample Gene Expression Profiles 1.0 0.891539 CRCGN016_MCF10A.WT.HP_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0079 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null denatonium benzoate-5480 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_16837_KO_Sufu/Spop_SRP145845 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 HDAC2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE106661,GSE106665_2_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE151829,GSE151831_7_v_8_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null GSE57871_8_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null M059J Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18248 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K36me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-670 TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 B cell_Kidney_Human CellMarker Gene-Cell Type Associations 1.0 null H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DUOXA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00881561 HCC202 COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Aurora A Inhibitor I_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141833 GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18004 H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF665 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58943 H3K18ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CACNA1S LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0107483 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A39996500_radicicol_SKBR3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ELF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null suloctidil-6675 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39367 regulation of gtpase activity GO Biological Process Annotations 2015 1.0 null Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.9609 CCND1 ChEA Transcription Factor Targets 1.0 null GSE213588_8_v_6_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4652-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 ML365 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.3 TCS 1102 DeepCoverMOA Drug Mechanisms of Action 1.0 0.34 SDHD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00791474 habenula (old epithalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43014 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K11558771_-666_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74O-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE252857_1_v_0_prednisone_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_0_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SKHEP1 DepMap CRISPR Gene Dependency 1.0 2.54209 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null methylphenidate_mus musculus_gpl11180_gse33619 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Antibody Deficiency Due To Defect In Cd19 DisGeNET Gene-Disease Associations 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.898965 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.55946 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.0903 Centriolar satellite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.579 MCF7_Prednisone_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159567 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.987556 BRD-K43901257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13353 SMC3 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_16482_KO_Irf6_SRP173804 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.83226 MET_knockout_247_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.17303 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13345_KD_Sp1_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.26955 GSE109140_0_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QVUS-0626-SM-447CC GTEx Tissue Sample Gene Expression Profiles 1.0 0.85527 BRD-K03624299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08115 BACH1 ENCODE Transcription Factor Targets 1.0 null GTEX-PW2O-0226-SM-48TC7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06704 KDM6B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00611459 Postpiriform transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09055 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67616 GTEX-OXRN-1326-SM-3LK5V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975635 intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244486 BRD-A99445203 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81981 GSE227698_5_v_0_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null lateral hemisphere of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28334 NCIH650 DepMap CRISPR Gene Dependency 1.0 2.05725 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K76450502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3882 IMR32 DepMap CRISPR Gene Dependency 1.0 2.58929 LTN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00559791 FOXM1 ENCODE Transcription Factor Targets 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_UNC1999_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180739 lateral group of nuclei, left, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.94484 periventricular stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33016 Endocytic regulation via ubiquitination 1 CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null BRD-K91191855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68771 IRF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31248 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13225 3948_HSD17B10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.532397 PRKAA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00592745 superficial stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11694 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2307 GSE189653,GSE203344_2_v_1_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12539 anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13871 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.165 GSE97352_3_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null neostigmine bromide-2432 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Centrosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 FOXM1_01_223 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.63875 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.3 Perturb_10406_KO_Ifnar1_SRP291997 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.94851 GUCA1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11486 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of organelle assembly GO Biological Process Annotations 2023 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4SW-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K23430405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44662 Perturb_10832_KO_Xbp1_SRP197108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 BRD-A77181042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31059 GTEX-WXYG-2326-SM-4E3I6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18894 GSE48812_9_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2745 15897907-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null KYSE-270 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66452 CRCGN015_MCF10A.TP53.M_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12928 CP-944629-7502 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE223334_1_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.842 BRD-K73027631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09485 DCSTAMP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00800477 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brody myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.201 Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE147876,GSE147877_4_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Microtubule cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 cerebellar cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06722 BRD-K72519622 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61075 MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.10322 establishment of protein localization GO Biological Process Annotations 2015 1.0 null amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20672 CRCGN016_MCF10A.WT.HP_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00332 Perturb_5876_OE_Six1_SRP141174 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.00737 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.82157 sirolimus-4431 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94141 GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879674 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28399 GTEX-XMK1-1026-SM-4B65H GTEx Tissue Sample Gene Expression Profiles 1.0 1.96694 BRD-K29420358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88607 NR3C2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00450124 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R1a-SM-33HCB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28504 GSE193351_1_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45406 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.07616 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.18906 organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.053204 LIMK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00418264 CRCGN015_MCF10A.WT.HP_24H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21362 SH2B3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0045135 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RXRA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR3-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38736 ERG ChEA Transcription Factor Targets 1.0 null CCDC77 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00729872 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63046 ACHN CCLE Cell Line Gene CNV Profiles 1.0 1.39964 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73680186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.43392 GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tretinoin-5767 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Overnutrition DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.202 disorders GeneRIF Biological Term Annotations 1.0 null Mental Retardation DisGeNET Gene-Disease Associations 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL2_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null Ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.219 core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.830361 PPP2R5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00537945 BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20284960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08848 JVM-2 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.30883 BRD-A19766589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63823 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K92803674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03986 FOXA2 ENCODE Transcription Factor Targets 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_1127_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.60214 GNA15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00454634 Primary motor area, Layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10468 RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25825 HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.884388 DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.492271 HNF4A ChEA Transcription Factor Targets 1.0 null medial habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.891171 metixene-3313 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NUP153 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7736 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04718 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.50971 diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null spleen_3c HPA Tissue Sample Gene Expression Profiles 1.0 0.964174 adult testis HPM Cell Type and Tissue Protein Expression Profiles -1.0 -0.879958 BRD-K96733881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25407 BRD-K51927648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75929 PMC6986448__F3 PFOCR Pathway Figure Associations 2024 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1 ChEA Transcription Factor Targets 1.0 null GSE129389_0_v_6_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null Mammary gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.050061 BRD-K24965236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.04492 H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K45746021_CC-401_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_16484_KO_Ikk2_SRP131881 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.75624 UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252971 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855815 CRCGN015_MCF10A.WT.HP_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01909 CRCGN014_HEPG2_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00447 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymph node HPA Tissue Protein Expression Profiles 1.0 0.804578 GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28138 H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-3186-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 JMJD8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00585452 BRD-K82397896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07285 NTRK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00663607 DLG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0049957 smooth muscle HPA Tissue Protein Expression Profiles -1.0 -1.12523 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K70468140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25369 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16037 GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83524 TMEM39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19539 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 EJM CCLE Cell Line Gene CNV Profiles 1.0 1.60782 496100336_TCx_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.01391 CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.32521 K562_S-Ruxolitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.031515 BRD-K56708236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47594 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SERPINE2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00725215 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LGLL - Large granular lymphocytic leukemia_Peripheral blood mononuclear cell_GSE10631 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.74913 GSE114883_1_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null EPHA4_drugactivation_229_GSE26523 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.16486 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TGBC1TKB Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.64368 BRD-K76543697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32674 CCN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00609551 BAG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00599071 dorsolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.931578 GSE146074_10_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08466 GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null pyramidal layer of IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06152 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903314 GSE126776_2_v_1_pelp1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K26435104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0308 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85424 Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2367 GSE57871_11_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HT1376 CCLE Cell Line Gene CNV Profiles 1.0 2.26686 cytoplasmic part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.437208 COR-L26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27552 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.89248 CNTN4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00579293 Perturb_14832_KD_Scr_SRP017110 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.46542 MYL9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00414626 BV173 CCLE Cell Line Gene Expression Profiles 1.0 1.48717 SLC9B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00667776 KDM5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40401 superficial stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67306 REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4873-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32402344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.31187 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11629 Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GFI1B-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE189653,GSE203344_5_v_3_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMCD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0065292 ovary_8a HPA Tissue Sample Gene Expression Profiles -1.0 -1.19578 BRD-K09078201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14767 large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.321909 NPHP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.658 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAST1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00528432 Perturb_1154_KO_USP29_SRP329795 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.37488 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045705 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.38312 periventricular stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44889 Phosphomannomutase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.867 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05627 GTEX-XQ3S-1526-SM-4BOOC GTEx Tissue Sample Gene Expression Profiles 1.0 1.13813 IGROV-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GMPPB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00622377 BRD-K06926365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21511 A549_Ellagic acid_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0114213 GSE142210_3_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A63503250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00815 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841647 CF-50-QK79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.293972 Ethynyl Estradiol DeepCoverMOA Drug Mechanisms of Action 1.0 0.35 Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A6I9-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K53388755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.72697 ChIP_REST_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null USF MotifMap Predicted Transcription Factor Targets 1.0 null LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.918572 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE181431_0_v_1_calr_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00222 RCBTB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0059043 Lung adenocarcinoma_LUAD_TCGA-75-7025-01A-12R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Medial habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46483 BRD-K54007898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17687 JMSU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.53711 REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67309 KP3 CCLE Cell Line Gene CNV Profiles 1.0 1.37789 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null JPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05505 K562_Aminoglutethimide_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182111 K562_Ruxolitinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177012 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08217 dilazep-3665 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_13151_KO_Atxn7l3_SRP269420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.81713 K562_PF-573228_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0268262 procarbazine-5452 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K25423143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18574 medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13225 GATA3 ENCODE Transcription Factor Targets 1.0 null GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68966 FOSL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00500533 GSE234043_0_v_1_abcb1_human RummaGEO Gene Perturbation Signatures 1.0 null XPOT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31733 alprenolol-7141 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917714 BRD-K01754917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65028 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05503 YY1-33199912-293T-HUMAN-KIDNEYEMBRYO ChEA Transcription Factor Targets 2022 1.0 null MS4A13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00525819 PTPRC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00550132 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HI-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RUSQ-0126-SM-47JWV GTEx Tissue Sample Gene Expression Profiles 1.0 1.12471 TEX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00532769 Lung adenocarcinoma_LUAD_TCGA-78-7149-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IFNA10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00586287 GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE210885_5_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null ARHGAP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3451 BRD-K07881437_S1107_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CXCL10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00848707 KLF6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00634201 BRD-K57323824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.85431 Rabaptin, GTPase-Rab5 binding domain InterPro Predicted Protein Domain Annotations 1.0 null BRD-K29328556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01928 H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null sulfamethizole-5798 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02548 vesicle-mediated transport GO Biological Process Annotations 2015 1.0 null PPP1R16B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00612494 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152441,GSE152442_0_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE236504,GSE236505_0_v_1_atmin_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AI-1126-SM-48U19 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58503 piriform cortex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.52429 TSSK1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.005382 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.32653 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRIN2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00698711 periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7682 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.879407 CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-2026-SM-2S1O4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.972687 paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39307 POU2F2 ENCODE Transcription Factor Targets 1.0 null GSE153064,GSE153065_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.089 Obesity GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.81549 RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79807180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.04104 EGR1 ENCODE Transcription Factor Targets 1.0 null PGR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0462 BRD-K45289917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09412 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PF-573228_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0203943 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CLPP NURSA Protein-Protein Interactions 1.0 0.228297 TNNI3K LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00485196 GSE214823,GSE214824_6_v_7_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K85708426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52165 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HTR1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00732618 Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CTV1DM DepMap CRISPR Gene Dependency 1.0 3.24127 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MBD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41639 K562_TG101209_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0217212 GSE246911,GSE246913_4_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TD-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00467106 RIPOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04008 K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.927091 ELF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K62372121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2238 PKN3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00591327 BRD-K68060538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.25277 KMS26 CCLE Cell Line Gene CNV Profiles 1.0 1.58308 MCF7_Thiotepa_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.018042 496100556_TCx_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.42478 NR2F2 ENCODE Transcription Factor Targets 1.0 null GAB3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00544706 LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null Tadalafil DeepCoverMOA Drug Mechanisms of Action 1.0 0.27 Progesterone DeepCoverMOA Drug Mechanisms of Action -1.0 -0.33 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K91511557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01097 growth factor activity GO Molecular Function Annotations 2015 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAL1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE94849_1_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-TKQ1-1026-SM-4GICL GTEx Tissue Sample Gene Expression Profiles 1.0 0.961214 CLEC10A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00919406 TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146074_6_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24273 BRD-A48478073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23518 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Taenia tecta, dorsal part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90745 CRCGN015_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.13728 BRD-K02630367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24588 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832315 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130246_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BICR78 COSMIC Cell Line Gene Mutation Profiles 1.0 null TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K90049800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.55087 ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.7536 A549_Fulvestrant_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188915 FD-15-HD09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306688 GSE148692,GSE148695_2_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null periventricular stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01317 BRD-K43918778 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0515 FOXP2 ENCODE Transcription Factor Targets 1.0 null left colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.22648 DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.442846 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K92356505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5211 Body fat distribution (leg fat ratio) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 MCF7_Ki8751_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166196 skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -1.12523 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hyperplastic GeneRIF Biological Term Annotations 1.0 null GSK3B_knockdown_208_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 3.29559 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.066 GSE114690_1_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE165548_2_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null SLC5A6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00321379 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX1 ChEA Transcription Factor Targets 1.0 null PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null BRD-K76415727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.36947 STAT1 ENCODE Transcription Factor Targets 1.0 null Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.426 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38302 BRD-K78119702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28291 Perturb_6997_KO_Cap2_SRP182037 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.47844 Bed nucleus of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59494 BRD-K86467057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35622 HCC2998 BioGPS Cell Line Gene Expression Profiles 1.0 0.908803 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.87809 Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62256869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88927 r10 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31186 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.831217 BRD-A05456882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00591 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0686 CRCGN014_HEPG2_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07236 RIOK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00647137 layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.77555 MOB3A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00733521 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06308228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41871 Aorta thoracica TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.995 RHOD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06881 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10797_KO_Xbp1_SRP262377 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.4398 8305C COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956372 GTEX-NFK9-2226-SM-3MJGP GTEx Tissue Sample Gene Expression Profiles 1.0 2.8568 Carotid artery occlusion DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.23 BRD-K45134469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47476 BRD-K41323747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78851 GSE193258,GSE193259_5_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null NB1 DepMap CRISPR Gene Dependency 1.0 2.38279 BRD-K12115687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2408 hsa-miR-125a-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null FOXA1-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053532 TCF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2926 GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 1.28067 GSE207302,GSE207303_0_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null meclofenoxate-3405 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48356 GSE150669_0_v_1_roxadustat_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_15620_KO_Net39_SRP273304 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.1018 PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null K562_GSK-LSD1 2HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0413458 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null flecainide-3761 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ADK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00601977 GCDH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00605458 Anterior cingulate area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15212 K562_Cimetidine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0195151 Microtubule organizing center COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Triple-Negative Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null beta-escin-2194 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.555 GSE145430_0_v_1_zmat3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRY ChEA Transcription Factor Targets 1.0 null GSE107956,GSE107957_0_v_1_ythdf2_human RummaGEO Gene Perturbation Signatures -1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEACAM7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00632764 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885217 ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_180_MITF Rummagene Transcription Factor Associations 2026 1.0 null HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.54029 H3K9me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-IS-A3K7-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05181 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.22371 BRD-K86232198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22888 NRROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21051 GSE232786_1_v_0_otud1_human RummaGEO Gene Perturbation Signatures 1.0 null positive regulation of metabolic process GO Biological Process Annotations 2015 1.0 null ZNF280B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01816 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88494268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18971 BRD-K55187425_ON-01910_MCF7_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null valdecoxib-6378 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 18310505-TableS7 GeneSigDB Published Gene Signatures 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE225900_1_v_0_hsdl2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures 1.0 null VCAP CCLE Cell Line Gene CNV Profiles -1.0 -1.74604 Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42797038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53139 COQ6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00620192 obesity GWASdb SNP-Phenotype Associations 1.0 1.26545 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null No annotation - 1 CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null superficial stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16635 HMB-Val-Ser-Leu-VE DeepCoverMOA Drug Mechanisms of Action 1.0 0.34 STAT1::STAT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.4726 NCIH2141 CCLE Cell Line Gene Expression Profiles -1.0 -1.45765 BRD-K83270526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44668 BRD-K51972131 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.70732 Pervasive developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.226 SNUC4 CCLE Cell Line Gene Expression Profiles 1.0 1.3867 PMC12311696-ao5c02807_si_001.pdf-18-SAFB2_SAFB2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFG8-1826-SM-4LVM4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.63176 6768_PRKDC_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.526677 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDAMB361 DepMap CRISPR Gene Dependency 1.0 2.91577 GSE176008_7_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78712486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15266 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Pirarubicin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161594 AF-41-QY60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25483 BRD-A39996500_radicicol_MCF10A_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PROM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00621264 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.9398 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_ENMD-2076 L-Tartaric acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155053 LIG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0099334 GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92011 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21021 GTEX-PWO3-0011-R1A-SM-2I5EW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912844 MCF7_Lomustine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145054 lateral part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67601 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147240_3_v_1_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832315 GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21827 Hereditary mixed polyposis syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.325 6793_PRPF31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.530025 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995061 Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.743073 Cholestasis CTD Gene-Disease Associations 1.0 1.08726 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prelimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04475 orphenadrine-2318 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null acepromazine-2769 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67058 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A68631409_Evodiamine_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50478 LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.66204 BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6445 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29849 GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles 1.0 2.01307 TAL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SIN3A ChEA Transcription Factor Targets 1.0 null NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null TRIM28_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null including GeneRIF Biological Term Annotations 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.865306 NCIH1184 CCLE Cell Line Gene Expression Profiles -1.0 -1.89924 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NDUFV1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00639842 ketoprofen-3729 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_10703_KO_LRP1_SRP154940 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74325 Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.2373 H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE197555_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-S4Q7-1026-SM-4AD75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28053 REEP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96021 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PBX3 ENCODE Transcription Factor Targets 1.0 null SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4QR-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Raltitrexed_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205621 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.979098 REST ENCODE Transcription Factor Targets 1.0 null RFX5 NURSA Protein-Protein Interactions 1.0 0.081964 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10976 BRD-K84745303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20942 GSE158834_11_v_5_palm_human RummaGEO Gene Perturbation Signatures 1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCL5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00558934 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -3.26782 Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.637936 GTEX-PLZ6-0126-SM-48TC6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28879 hsa-miR-378a-3p MiRTarBase microRNA Targets 1.0 null TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.944509 SLAMF7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0074629 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942195 MCF7_RG108_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146614 A549_EED226_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0123675 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU685 DepMap CRISPR Gene Dependency 1.0 2.39305 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8047-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:I03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37093 CARD14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00708359 BRD-K47271260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07342 PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V_2-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC Rummagene Transcription Factor Associations 2026 1.0 null FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65780164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01293 BRD-K51897928 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03768 Morbid obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.228 prostate_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.7568 451LU COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K51322795 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25783 GSE148692,GSE148695_2_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Rucaparib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0237067 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Arteriole TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.517 CP-690334-01-3826 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WDR87 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00452717 CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10281 Infralimbic area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10403 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of metabolic process GO Biological Process Annotations 2015 1.0 null epithelial cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hematopoietic system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CLCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13129 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.29473 USF1 ENCODE Transcription Factor Targets 1.0 null Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.9953 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00594816 K562_Roxadustat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187192 PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56283394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82447 PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF Rummagene Transcription Factor Associations 2026 1.0 null MARS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00654186 hsa-miR-1266 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 SYNM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00689188 SYPL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00596844 lymphnode_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.15203 PANK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29036 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1625 BRD-K20501114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75757 GTEX-UTHO-0011-R5A-SM-3GIJD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18635 Perturb_13211_OE_Sall4a|Sall4a_ERP122254 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.91636 RHO LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00577632 GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62055 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERA-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null dexibuprofen-6712 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2A MotifMap Predicted Transcription Factor Targets 1.0 null Stalk cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.169 PMC8528285-pbio.3001085.s010.xlsx-Fig_S8A-MLX_3T3_MLX Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24829 PC14 CCLE Cell Line Gene CNV Profiles 1.0 1.42579 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.91306 Perturb_10827_KO_Xbp1_SRP262377 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49974 PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_22-Supplementary_Table_22_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_Beat-AML_cohort_TET2 Rummagene Transcription Factor Associations 2026 1.0 null MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HELA Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.00913 TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null thorax TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.04522 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075098 Brain - Frontal Cortex (BA9) GTEx Tissue Gene Expression Profiles 2023 1.0 3.73117 RCOR3-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CDK8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00483248 HT-1197 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE151782_1_v_5_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37219 PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null CEBPD_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Orbital area, ventrolateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49718 hexamethonium bromide-1482 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCF7_Meprednisone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149784 UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208807 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.80529 GSE171837_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null A549_Quercetin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136301 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02473 OV90 DepMap CRISPR Gene Dependency 1.0 2.32289 MZ2-MEL GDSC Cell Line Gene Expression Profiles -1.0 -1.64311 molecular_function GO Molecular Function Annotations 2015 1.0 null GSE68155_3_v_2_gpr3_mouse RummaGEO Gene Perturbation Signatures -1.0 null ALAD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00554825 GSE143643,GSE143644_3_v_5_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null REV3L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00818578 isoconazole-7211 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null BRD-K49409924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27401 GTEX-XAJ8-1426-SM-47JYM GTEx Tissue Sample Gene Expression Profiles 1.0 1.1885 regulation of cilium assembly GO Biological Process Annotations 2023 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.55253 Perturb_7025_KO_Mtfp1_ERP132295 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.1422 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.995236 breast TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GATA1_G1E-ER4_mm9_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sirolimus-2667 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K42960858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.9058 disease of metabolism DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.544585 BRD-K85851814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30352 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01866 BRD-A52794651 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03604 BRD-K22812176 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10973 A549_Divalproex Sodium_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147788 CTSC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0059601 GSE178714_5_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K12867546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.78199 Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-1226-SM-4IHL8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.835318 retrohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01444 SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.4604 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16199 GTEX-SNOS-1026-SM-4DM4Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.19387 BRD-K20451745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17865 H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MSS51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72621 POLR2E Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PFKFB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00664398 MAX ENCODE Transcription Factor Targets 1.0 null BRD-K99944747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45038 AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27843 GTEX-OIZG-0726-SM-33HBL GTEx Tissue Sample Gene Expression Profiles 1.0 0.992319 GSE207135_1_v_0_sod2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K09250647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34404 Perturb_2955_KD_Mef2a_SRP046331 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.85021 dehydrocholic acid-1523 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null imatinib_homo sapiens_gpl96_gds3042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_17819_KO_Bmal1_SRP260650 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-V1D1-0226-SM-4JBHG GTEx Tissue Sample Gene Expression Profiles 1.0 0.882844 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18083 ATF3_02_54 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59121 BRD-K39120595_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PSMB5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00573596 NACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60064 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206025 3291_GATA1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.638932 r10 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20966 GGT7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00510243 GSE187006_0_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FFAR4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00591198 DPRX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1109 GTEX-NPJ8-0011-R5a-SM-2HMJY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.926552 KLF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22151 Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00995 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67309 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39939 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28579 BRD-K83139520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3604 CRIP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0061898 PSRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48982 CYP24A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00691816 SUSD4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00749698 ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null MCF7_Sodium Phenylbutyrate_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143113 GSE74528_0_v_1_trex2_mouse RummaGEO Gene Perturbation Signatures -1.0 null endosome membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.725705 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14878 GSE242647_2_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKDC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00604558 SR786 CCLE Cell Line Gene CNV Profiles 1.0 1.69002 Perturb_11593_OE_MYOD1_SRP105281 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.9857 GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.978384 CTCF ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72933250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31218 CRCGN017_MCF10A.WT.HP_24H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94983 Inflammation CTD Gene-Disease Associations 1.0 1.35328 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AdrenalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.917136 GSE129725_1_v_5_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC6097700-pgen.1007515.s012.xlsx-S6_Table-S6_Table_Full_gene_names_their_known_biology_and_associated_phenotypes_for_associated_genes_from_the_SATB2_NuRD_and_SATB2_Cort_gene-sets_SATB2 Rummagene Transcription Factor Associations 2026 1.0 null EOMES-20176728-TSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A.WT.HP_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25737 BRD-K34425773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29997 BRD-K71194915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09663 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZH-0926-SM-4DXU4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.61349 GATA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10926 HCC95_LUNG CCLE Cell Line Proteomics 1.0 2.34381 Asphyxiating thoracic dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.276 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E6-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A549_UNC0379_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106628 C2orf49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87209 GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 3.6428 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.81173 GTEX-QDT8-0011-R5A-SM-32PKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840625 PMC6986448__F3 PFOCR Pathway Figure Associations 2023 1.0 null SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01898 central medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.953496 JR DepMap CRISPR Gene Dependency 1.0 2.06746 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4011 nucleus subputaminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854439 NREP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00846825 K562_Mocetinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0133023 BRD-K96164740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77396 GSE234340_10_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53957 GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52247 Hypertrophy CTD Gene-Disease Associations 1.0 1.32547 MYOD1 ENCODE Transcription Factor Targets 1.0 null K562_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137235 SPPL2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0073423 SNAPC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0051781 MBD4 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K33379087_tivantinib_MCF7_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE168798_0_v_1_isg15_human RummaGEO Gene Perturbation Signatures 1.0 null PCDHB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39827 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056936 H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2149 MCF7_Capecitabine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0193784 MCF7_CYC116_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0111254 MCF7_Thiotepa_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0131365 K562_AMG-900_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157274 CTNNB1-20460455-HCT116-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.811425 LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.430626 GTEX-T2IS-0826-SM-4DM6L GTEx Tissue Sample Gene Expression Profiles 1.0 0.827513 BRD-K76174882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19885 BRD-K19672435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54995 RPMI-6666 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.17932 PRKCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28218 NCOR1 ENCODE Transcription Factor Targets 1.0 null TNFSF12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0046534 FOXA1 ENCODE Transcription Factor Targets 1.0 null CD84 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00733124 GTEX-OXRN-0126-SM-48TDM GTEx Tissue Sample Gene Expression Profiles 1.0 0.830521 CAMK2G LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0058688 MIR34_OE_GDS2755_645_human_HCT116 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null cytoplasm GO Cellular Component Annotations 2015 1.0 null GSE245134_2_v_3_atg5_mouse RummaGEO Gene Perturbation Signatures -1.0 null pipemidic acid-6470 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cytosol COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47217 RNF207 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79708 Perturb_1683_KO_Nox4_SRP356837 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.12951 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K22447639 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43871 K562 DepMap CRISPR Gene Dependency 1.0 3.12367 H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -3.07514 BRD-K86070914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02022 growth abnormality GWASdb SNP-Phenotype Associations 1.0 0.353738 BRD-K87092114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28701 MCF7_Ki16425_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155406 localization GeneRIF Biological Term Annotations 1.0 null COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1214 BRD-K47292239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2204 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DGKG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00558792 BRD-K62833556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02273 posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13736 intracellular GeneRIF Biological Term Annotations 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Pelitinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140872 TC-N 22A DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 ZBTB7A ENCODE Transcription Factor Targets 1.0 null PMC12480102-41525_2025_515_MOESM2_ESM.xlsx-ST12-Unnamed_2_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-1626-SM-4LVMY GTEx Tissue Sample Gene Expression Profiles 1.0 2.04062 Prostate adenocarcinoma_PRAD_TCGA-V1-A8MF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114883_0_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.07171 Tiplaxtinin DeepCoverMOA Drug Mechanisms of Action 1.0 0.32 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Fasudil_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156658 Perturb_15888_Mut_Tbx5_SRP306874 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.26691 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C Rummagene Transcription Factor Associations 2026 1.0 null pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.975015 NCI-H1155 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_10200_KD_HNRNPUL1_ERP118119 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Lung squamous cell carcinoma_LUSC_TCGA-77-8154-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Inflammatory bowel disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.273 GSE138945,GSE138947_0_v_1_mboat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null KLF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.9262 CBX3 ENCODE Transcription Factor Targets 1.0 null BRD-K30252238 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75641 K562_Linifanib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146737 GTEX-OHPL-0126-SM-2HMJ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12948 BRD-K42809349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52872 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.635025 POLH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00470345 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null efo21 HPA Cell Line Gene Expression Profiles 1.0 0.999042 KDM2B-26808549-CHIP-SEQ-SUP-B15-HUMAN ChEA Transcription Factor Targets 2022 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957582 Perturb_13568_KD_Kctd10_SRP292969 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.5686 intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.318999 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EE-98-PF86_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203462 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsal part of alar p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43176 Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.9613 Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91189 CRCGN017_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37321 SP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46018 skeletal muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-W5WG-1826-SM-4KL2Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.17036 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null S-propranolol-2961 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K83459401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34281 GTEX-OHPM-0126-SM-2YUN9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12217 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-0126-SM-4DXSN GTEx Tissue Sample Gene Expression Profiles 1.0 1.04925 BRD-K04399953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01388 Perturb_16464_OE_Zfp36_SRP255505 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.42902 GTEX-TKQ2-1326-SM-4DXT9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0128 Ciliary transition fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.895 Perturb_2151_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.3659 BRD-K70969650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.76106 prostate_4c HPA Tissue Sample Gene Expression Profiles 1.0 0.910783 DDC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00459784 IZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.837873 Rectum adenocarcinoma_READ_TCGA-DC-6154-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K64055457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12619 PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_Ensembl_that_KD_acts_upon_AR Rummagene Transcription Factor Associations 2026 1.0 null 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.52818 H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE216043_10_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 1.33121 TE8 DepMap CRISPR Gene Dependency 1.0 2.23548 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.0235 CRCGN015_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.05948 GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34465 20460173-ImmPortCytokines GeneSigDB Published Gene Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52175660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.29297 BRD-K10684867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40404 NDUFA7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00377191 GSE100316_0_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null CDKN2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00476255 NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.879786 superficial stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60586 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_UNC0379_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151675 isradipine-5447 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleoside-triphosphatase regulator activity GO Molecular Function Annotations 2015 1.0 null CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12942 MCF7_JNJ-7706621_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168101 MCTP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00621106 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HNF4A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL4W-0011-R4a-SM-2I5GZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93621 HCFC1 ENCODE Transcription Factor Targets 1.0 null MCF7 BioGPS Cell Line Gene Expression Profiles 1.0 2.20408 Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 58.4734 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE160001,GSE160670_3_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null BRD-K79732056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15095 K562_S3I-201_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157373 BRD-K74506898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43069 BRD-K70511574_sunitinib_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WFG7-1826-SM-3GIL1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24904 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rectum_8c HPA Tissue Sample Gene Expression Profiles -1.0 -0.915135 BRD-K42126155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57037 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42177 NFYA ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIVEP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00767391 GTEX-XPVG-2126-SM-4B667 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28503 GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890102 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05035 BRD-K66985689 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51252 Thiamet G DeepCoverMOA Drug Mechanisms of Action 1.0 0.45 KP-N-YN GDSC Cell Line Gene Expression Profiles -1.0 -1.6479 STK066844 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.45 Perturb_16679_KO_SiglecE_SRP350344 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.7952 19429869-TableS1 GeneSigDB Published Gene Signatures 1.0 null NUDT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15301 GFI1B-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31844308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2905 HCC1569 COSMIC Cell Line Gene Mutation Profiles 1.0 null PFDN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00425158 CD3G LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.007329 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.949063 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-A47A-01A-21R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bone marrow cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05203 WM3211 DepMap CRISPR Gene Dependency 1.0 2.93906 GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70678 INSM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00600561 BRD-K44520987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09934 ALEXANDERCELLS CCLE Cell Line Gene Expression Profiles -1.0 -1.45982 GTEX-S3XE-0126-SM-4AD4R GTEx Tissue Sample Gene Expression Profiles 1.0 1.03297 YY1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158431_2_v_0_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K25470159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49123 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.831217 CISD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00619232 SNU182 CCLE Cell Line Gene CNV Profiles -1.0 -1.34328 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.47867 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-0126-SM-4BOP7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.933872 AB-33-EM56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.421518 bromopride-3719 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PKIB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00546564 BRD-K53127464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49638 FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC Rummagene Transcription Factor Associations 2026 1.0 null NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.873603 GSE207301,GSE207303_1_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE165579_3_v_2_opa1_mouse RummaGEO Gene Perturbation Signatures 1.0 null r5 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26885 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8841 SLC22A23 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00716203 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.870711 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K45762887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46914 K562_Anacardic Acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.021316 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABRQ LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00733041 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.77254 MFE-296 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K37049577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32032 Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.050027 GTEX-WFJO-0926-SM-4LVM2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.72389 SPAG9 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-VJYA-0126-SM-4KL1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.46808 H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00765 CRCGN016_MCF10A.WT.HP_24H:G10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81547 CDKN1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00463817 SA-32-CC58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.443381 ESS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75457 BRD-K47599758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21991 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37903 FOXO3-22982991-MACROPHAGES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null regulation of biological process GO Biological Process Annotations 2015 1.0 null TRIM54 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0118464 CTCF_epithelial cell of esophagus_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.87451 BL2255 (PRKRIR) NURSA Protein Complexes 1.0 null CD96 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00758358 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-1626-SM-2S1QW GTEx Tissue Sample Gene Expression Profiles 1.0 0.971213 BRD-K45172622 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07997 t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.41155 dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49974 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45293 BRD-K06863921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05824 Anterior cingulate area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11274 REST-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-UPK5-2026-SM-4JBIM GTEx Tissue Sample Gene Expression Profiles 1.0 2.32144 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGBC1TKB GDSC Cell Line Gene Expression Profiles -1.0 -2.23213 GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles 1.0 1.11675 NCIH1793 CCLE Cell Line Gene CNV Profiles -1.0 -1.68076 CCL21 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00637284 hsa-miR-3922-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 H4K20me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RH30 DepMap CRISPR Gene Dependency 1.0 5.55704 HEC251_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.21057 Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03106 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.96581 GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66663 sulfasalazine-2882 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU324 CCLE Cell Line Gene CNV Profiles -1.0 -2.80501 GSE94849_6_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_10798_KO_Xbp1_SRP262377 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.79026 RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.3221 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957582 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE147876,GSE147877_4_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S341-1726-SM-3K2AK GTEx Tissue Sample Gene Expression Profiles 1.0 1.54675 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834099 LAMP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00773056 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.72359 CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_GSK-LSD1 2HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0412398 GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69017 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22854 GSE149621_0_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE132694,GSE132717_0_v_2_meis1_human RummaGEO Gene Perturbation Signatures -1.0 null GUCY2F LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0046848 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.833181 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fh4 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.775 JHH6 CCLE Cell Line Gene Expression Profiles -1.0 -2.81697 RHOU LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00722422 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.861617 TXNRD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00409304 PES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30078 BRD-K60780031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.023 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.700718 A549_Tazemetostat_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0185524 CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K60456515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00792 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null BRD-K03953354 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03354 mantle zone of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43257 BE2-M17 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.83777 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21148 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K91500340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33953 NCIH2347 CCLE Cell Line Gene CNV Profiles -1.0 -1.91411 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_4_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-1326-SM-3NB1H GTEx Tissue Sample Gene Expression Profiles 1.0 1.26535 BRD-K40610042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.47293 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.003 HCC1937 DepMap CRISPR Gene Dependency 1.0 4.63693 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NALM-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.856282 Perturb_4837_OE_Atoh1_SRP220284 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.06695 Siponimod DeepCoverMOA Drug Mechanisms of Action -1.0 -0.43 GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11926 GSE193351_1_v_2_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null trunk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IRF4 ENCODE Transcription Factor Targets 1.0 null MCF7_Thalidomide_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184597 GTEX-SUCS-1926-SM-32PM3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.59486 TFCP2L1 ChEA Transcription Factor Targets 1.0 null PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01266518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30933 citiolone-3836 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 BRD-K88200581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19418 A549_Fasudil_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0156351 REEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30648 CYP27B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00769807 FLI1 ChEA Transcription Factor Targets 1.0 null haloperidol-6203 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UMUC1 CCLE Cell Line Gene CNV Profiles 1.0 2.44662 GSE184892_0_v_1_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null 19218430-TableS3 GeneSigDB Published Gene Signatures 1.0 null KD DepMap CRISPR Gene Dependency 1.0 4.40712 HAPLN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00521117 Perturb_13324_KD_Junb_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.06591 MAP2K7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00428731 BRD-K79684522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61212 GSE248045,GSE248046_6_v_5_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null letrozole_homo sapiens_gpl3921_gse33366 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-97-A4M3-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSD17B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00645922 BRD-K05402890_17757146_HT29_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K91516693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77391 THPO LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00756938 ECT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57213 H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K50168500_canertinib_SKBR3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYD88 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00845245 naproxen-7146 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.09887 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223092 CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7166 BRD-K62017257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03318 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.873998 DHRS11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11346 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.985927 Fatty Liver CTD Gene-Disease Associations 1.0 1.28703 GSE111247_2_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29763 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.4396 Knight'S Move In Thought DisGeNET Gene-Disease Associations 1.0 null Isoproterenol DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 GSE153871_5_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.3752 GSE184892_0_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33231 Cerebral infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.236 BRD-K19580273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32658 EBF1 ENCODE Transcription Factor Targets 1.0 null GSE208254_3_v_1_irf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Epithalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32775 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42369 Lung BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.04383 BRD-K87803080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14555 BRD-K14394756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85572 SYK_knockdown_189_GSE54065 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.9446 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12077 ID4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00830748 Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00931 irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.907913 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5548 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.825278 Body mass index variance GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.12218 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20476 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null MOLM13 DepMap CRISPR Gene Dependency 1.0 5.45477 Type IV secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.783 membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 CRCGN013_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.70354 BRD-K31300534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23968 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null BRD-K90625171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7772 BRD-K47988839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19317 VAMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32358 GSE240344_1_v_0_uxs1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15992 BRD-K96779993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57184 NCIH196 CCLE Cell Line Gene CNV Profiles -1.0 -1.44955 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13647 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33665 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562_AR-42_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155391 ATF2 ENCODE Transcription Factor Targets 1.0 null TE10_OESOPHAGUS CCLE Cell Line Proteomics 1.0 7.41336 IFNA5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0073007 GSE158834_11_v_8_palm_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CAL148 CCLE Cell Line Gene Expression Profiles 1.0 1.45303 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73494324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26475 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-0126-SM-447BK GTEx Tissue Sample Gene Expression Profiles 1.0 1.71305 PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1419 CCLE Cell Line Gene Expression Profiles 1.0 2.98388 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENPEP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00641416 BRD-K05253426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49937 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SACM1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56617 BRD-K83603369 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16287 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parataenial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10337 colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.322273 BRD-K22322324_5120-0434_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WY7C-2326-SM-3NB2U GTEx Tissue Sample Gene Expression Profiles 1.0 0.8999 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17699775-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null mammarygland.lact. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.857181 hsa-miR-4518 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15556 RAD21 ENCODE Transcription Factor Targets 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.18812 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K70511574_sunitinib_MCF7_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZD-85-ND87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253136 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.06918 GTEX-SJXC-2026-SM-4DM6N GTEx Tissue Sample Gene Expression Profiles 1.0 2.30237 K562_Zileuton_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.034644 POU5F1 ChEA Transcription Factor Targets 1.0 null intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.07428 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33231 reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.825682 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.31706 Adenocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GZMA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00581701 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4960-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNFRSF10D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0074765 BRD-K55538850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42466 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40533 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.968374 acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.263997 GTEX-V955-1826-SM-4JBIL GTEx Tissue Sample Gene Expression Profiles 1.0 1.27884 GSE180951_6_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.379712 Perturb_15392_KD_CHD6_SRP399677 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.63914 EPLC-272H GDSC Cell Line Gene Expression Profiles -1.0 -1.47139 BE-68-PM13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.345453 Glomerular Filtration Rate DisGeNET Gene-Phenotype Associations 1.0 null CRCGN016_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.94752 Thymus-memory b cell Tabula Sapiens Gene-Cell Associations 1.0 2.8995 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67309 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35263 mediodorsal nucleus of thalamus_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.39012 Perturb_13350_KD_Tead2_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.20323 IGROV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.87309 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02637850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62285 GATA1_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3329 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null OCUBM DepMap CRISPR Gene Dependency 1.0 6.7687 6868_PSMD14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.745125 Early endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.582 BRD-K48255349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6264 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20721 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67309 NTERA2CLD1 DepMap CRISPR Gene Dependency 1.0 3.01251 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.961216 SR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46607 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QCQG-0226-SM-48U28 GTEx Tissue Sample Gene Expression Profiles 1.0 0.880065 BRD-K76985713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74409 H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Extremely high intelligence GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.769897 anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07506 LIPF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00582166 GTPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32942 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GATA2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Pontocerebellar hypoplasia type 1B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.199 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.82668 GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15308 GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06416 MAFK ENCODE Transcription Factor Targets 1.0 null AZD1152 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.48 BRD-K63960902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30174 GSE246184,GSE246195_0_v_1_sin3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K92428232_HY-50877_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EPHX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00874375 CRCGN015_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5158 MS (Multiple Sclerosis)_B Cell Lymphocyte_GSE10064 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.28658 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HD-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05055 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34981 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_11_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287962 LEP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00898389 intermediate part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15183 BRD-K08353229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1795 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BL8796 (DAB2IP) NURSA Protein Complexes 1.0 null GTEX-NPJ7-0011-R4a-SM-2I3GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02052 K562_Tofacitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0181026 Perturb_14909_KO_Peg10_SRP167954 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.01442 PIGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23847 LYL1 ChEA Transcription Factor Targets 1.0 null IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.488782 XEN 103 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.46 GTEX-P4QT-0126-SM-2I3FL GTEx Tissue Sample Gene Expression Profiles 1.0 0.916912 FXR MotifMap Predicted Transcription Factor Targets 1.0 null jund GeneRIF Biological Term Annotations 1.0 null Perturb_10584_KO_Tbx5_SRP191501 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.61898 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_11103_KO_Depdc5_SRP219943 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.81029 SETD7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00500043 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MK-1775 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.78 Rabaptin coiled-coil domain InterPro Predicted Protein Domain Annotations 1.0 null GSE140607_5_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Daphnetin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157008 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03382 Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.6676 COLO 849 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50276 GTEX-XBED-2226-SM-47JYQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.826721 GSE188458_2_v_4_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null Hepatomegaly CTD Gene-Disease Associations 1.0 1.16799 TCF3 ENCODE Transcription Factor Targets 1.0 null Schizophrenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.126 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pizotifen-5491 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 6889_PSPH_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.64558 FOXA1_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205729,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47865 UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22396 GTEX-OHPN-2726-SM-2I5H4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902188 GSE152441,GSE152442_0_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null Photoreceptor outer segment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.912 GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825259 AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01957 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37398853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76826 BRD-K67522096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6691 GATA2_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Timapiprant DeepCoverMOA Drug Mechanisms of Action 1.0 0.33 BRD-K92712225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33904 ZNF263 ENCODE Transcription Factor Targets 1.0 null mantle zone of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06217 Perturb_13590_KD_Crebl2_SRP214575 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.48634 H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18968 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19193 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27521 BRD-K82446079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76669 Acamprosate DeepCoverMOA Drug Mechanisms of Action 1.0 0.31 IL12A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00746842 GSE147876,GSE147877_4_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null LTF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00935731 FOXA1-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K38040305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46068 Parkinson Disease DisGeNET Gene-Disease Associations 1.0 null endometrium_8a HPA Tissue Sample Gene Expression Profiles -1.0 -0.971 SPATA2L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00646166 FASTK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00858418 receptor binding GO Molecular Function Annotations 2015 1.0 null TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null transport GO Biological Process Annotations 2015 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Obesity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.202 UO31 BioGPS Cell Line Gene Expression Profiles 1.0 0.879303 RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 146.818 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214442_0_v_1_pak4_mouse RummaGEO Gene Perturbation Signatures -1.0 null HPRT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00696147 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEPG2 BioGPS Cell Line Gene Expression Profiles 1.0 1.48558 PAX5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GNE-9605 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041881 CEBPE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00654881 meglumine-6445 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 18537972-TableS2 GeneSigDB Published Gene Signatures 1.0 null Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.303 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.99269 PSG5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00737924 NEUROD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00765471 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25553 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r7 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09428 BRD-K31437957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30704 K562_Momelotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0191462 CRCGN015_HEPG2_48H:B21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25518 SNX17 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00609769 valproic acid-4438 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNRF3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00643355 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.65335 FOXJ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22995 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GATA2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null monastrol-311 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inner CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27912 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PLPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2071 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 0.991279 LRRTM4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00591468 GSE223334_3_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null hepatoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02392 RGS13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00594837 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.945298 BRD-K37601439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58683 Perturb_2899_KO_Elavl1_SRP174217 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.42293 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17491 inner SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16335 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896062 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96505704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45055 Brain morphology (MOSTest) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.852288 22RV1 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K09168812 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29691 Taenia tecta, dorsal part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42769 AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.378205 GM97 BioGPS Cell Line Gene Expression Profiles -1.0 -0.937893 Perturb_4374_Mut_FOXO1_SRP242185 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.18704 LIME1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00602777 GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02151 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE169152_5_v_4_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null B3GNT5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685959 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8405_SRFBP1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.11923 CRCGN016_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40652 U118 BioGPS Cell Line Gene Expression Profiles 1.0 1.10411 BRD-K54604127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05852 CDC42 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0048833 H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100652_PCx_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.99374 MYBL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2186 SKNEP1 DepMap CRISPR Gene Dependency 1.0 3.96081 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE112761,GSE112767_2_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null BRD-K67399222 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11883 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4319 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.32994 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74628 YY1 ENCODE Transcription Factor Targets 1.0 null K562_Zileuton_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0196375 LC1F CCLE Cell Line Gene CNV Profiles 1.0 1.40859 BCB000038-7542 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ADGRA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0070259 GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07464 DCLK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00517738 GSE95688_7_v_5_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWO3-1526-SM-48TCM GTEx Tissue Sample Gene Expression Profiles 1.0 1.16743 skin HPA Tissue Protein Expression Profiles -1.0 -0.838866 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null SPI1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mesothelioma_MESO_TCGA-MQ-A4LI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null BRD-K49282125 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24204 CHI3L2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00856897 LZTS3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00651123 GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25449 Major island of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27773 Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KASUMI1 CCLE Cell Line Gene CNV Profiles -1.0 -2.03304 SP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 85.0275 fluocinonide-3839 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_8016_KD_MIDN_SRP361845 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.98295 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234340_9_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PDSS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00696522 troleandomycin-1465 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Body fat distribution (arm fat ratio) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.839794 GSE155305_3_v_0_ifitm3_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_16467_KO_Ncstn_SRP149348 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.44432 UBTF ENCODE Transcription Factor Targets 1.0 null activator GeneRIF Biological Term Annotations 1.0 null GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53553 OVISE Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.97113 vincamine-2327 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_PJ34_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146172 RASGEF1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00737792 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35308744 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29862 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.838529 TAGAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00564414 Perturb_4436_KO_Cbs1_SRP331019 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.64523 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11344 17699775-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01003 NCIH2081 CCLE Cell Line Gene CNV Profiles -1.0 -1.3887 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.4227 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989524 TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG8-0126-SM-4LVMH GTEx Tissue Sample Gene Expression Profiles 1.0 0.945082 Malignant tumor of pancreas_saliva_GSE14245 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.55448 BRD-K99609051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23113 BRD-K47098496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20192 GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13051 KDM6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76547 Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18 Rummagene Transcription Factor Associations 2026 1.0 null disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.544585 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040964 TIMP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00911441 PMC3728595-srep02327-s1.pdf-1622-ZBTB7B_ZBTB7B Rummagene Transcription Factor Associations 2026 1.0 null r3 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44889 K562_Sirtinol_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0295464 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GPX4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00436619 Perturb_15235_KO_Scl/Tal1_SRP179031 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.99582 TAF1 ENCODE Transcription Factor Targets 1.0 null AFD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00715218 TACR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00670007 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KYSE-410 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.1531 A549_PD98059_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016596 GSE218819_2_v_1_kdm5b_human RummaGEO Gene Perturbation Signatures 1.0 null BB-86-BE39_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215273 anabasine-6774 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.59778 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null enzyme activator activity GO Molecular Function Annotations 2015 1.0 null 17616640-TableS3 GeneSigDB Published Gene Signatures 1.0 null PHYKPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38466 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06629 MCF7_BMS-911543_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014098 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830245 SIPA1L1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00534235 APEH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00687792 ELK4 JASPAR Predicted Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95035301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31178 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76197651 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84753 H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.75164 GSE200352_10_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null ADCY1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00528888 intermediate stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46079 TBX18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28284 inner CP in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11782 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10495 ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU5F1-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null K562_Valproic acid sodium salt_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0193716 GSE151829,GSE151831_7_v_0_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-QDVN-0526-SM-48TZ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44068 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RL-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG ChEA Transcription Factor Targets 1.0 null regulation of hydrolase activity GO Biological Process Annotations 2015 1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.9621 GTEX-S95S-1226-SM-4GICG GTEx Tissue Sample Gene Expression Profiles 1.0 1.1539 GTEX-NL3H-0011-R2a-SM-2I3GG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979067 Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.96501 CRCGN015_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.38571 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null t47d HPA Cell Line Gene Expression Profiles 1.0 1.4308 skin_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.01385 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PCDHB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15049 WDR12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18842 SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null SIHA CCLE Cell Line Gene CNV Profiles -1.0 -1.66413 GATA1_G1E-ER4_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null colforsin-7059 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45009 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NEK10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00484882 CRCGN015_HEPG2_48H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07241 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.945298 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13964 Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BEN CCLE Cell Line Gene CNV Profiles 1.0 2.146 SYT11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00629376 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_1685_KO_Nox4_SRP356837 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.20273 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null parahippocampal gyrus, left, bank of the cos Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.972819 MOSMO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49173 E2F4-21247883-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KPNYN CCLE Cell Line Gene Expression Profiles -1.0 -2.03028 BRD-K70511574_S1485_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K21433749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09102 BRD-K33775409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09493 Intramolecular phosphotransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.867 GET4 Pathway Commons Protein-Protein Interactions 1.0 null NFE2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HER2_OE_GDS4763_331_human_MCF10A - immortalized breast epithelial cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null DNASE1L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00580195 BRD-K13792178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51666 IKZF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null doxycycline-7195 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.28297 lymphoid tissue TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BRD-K52319351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67119 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Alosetron DeepCoverMOA Drug Mechanisms of Action -1.0 -0.42 GSE146074_1_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81954791 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59212 r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30726 GATA1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40911 ALPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12423 BRD-A39996500_radicicol_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.16104 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07284 Bile canaliculus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.704 GTEX-OXRK-1726-SM-3NB16 GTEx Tissue Sample Gene Expression Profiles 1.0 0.974053 POU3F1-26484290-ESCSS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MCF7_Cimetidine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139695 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.433 betamethasone-valerate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61242 NCIH1092 CCLE Cell Line Gene Expression Profiles -1.0 -2.3231 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIRREL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00832972 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13328_KD_Mnt_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.3242 BRD-K93942001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20903 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.75211 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01003 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.964462 PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-BRCA1_448_TCF7_rep1_sorted_peak-Gene_Name_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Disulfiram_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0241199 EZH2 ENCODE Transcription Factor Targets 1.0 null BRD-K24681473_S1130_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MDA-MB-361 GDSC Cell Line Gene Expression Profiles 1.0 1.82207 NLRC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00577197 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.883143 hydrastine hydrochloride-2889 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null difenidol-7406 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K05789358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13013 GSE199255,GSE199356_6_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null tyloxapol-5672 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA Rummagene Transcription Factor Associations 2026 1.0 null APBB1IP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00576872 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03382 r8 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28638 IL2_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null MCF7_Alendronate sodium trihydrate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174916 periventricular stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21653 regulation of plasma membrane bounded cell projection assembly GO Biological Process Annotations 2025 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25453 rab9 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.311 posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.868311 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.797828 EBI3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00564454 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.29914 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.86338 karakoline-3741 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A36630025_-666_NCIH1836_6.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21108 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEPACAM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00824861 DOK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0083793 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5O9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null liver HPA Tissue Protein Expression Profiles -1.0 -1.12523 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00538806 BRD-K35646839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39341 GTEX-OXRN-0011-R10A-SM-2I5GC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04229 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33231 BRISC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.507 Anterior cingulate area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62479 RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4716 NRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68308 b220.bcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 POLR2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04244 BRD-K33461572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2039 SPI1 ChEA Transcription Factor Targets 1.0 null r9 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2275 liver HPA Tissue Gene Expression Profiles -1.0 -1.55697 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 0.912491 K562_Quercetin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166641 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08789 BRD-K71561082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.72273 K562_Tozasertib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0119563 MCF7_Epothilone A_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0189961 Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08532 BRD-K21680192_mitoxantrone_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rectum HPA Tissue Protein Expression Profiles 1.0 1.42494 cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8328-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.3664 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE125782_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null EIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28901 BRD-K38558166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.65071 ELF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7097 TE6_OESOPHAGUS CCLE Cell Line Proteomics 1.0 2.36876 TRIM28_knockout_301_GSE32224 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.45934 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05569 GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22596 BRD-K74834319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19945 PHA-00767505E-6550 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN010_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14434 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.983636 SOCS5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00703005 Thap11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0394 GSE140651,GSE140653_2_v_7_med1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918773 amygdalostriatal transition area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22507 FOS ENCODE Transcription Factor Targets 1.0 null IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.983184 EGR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.5996 BRD-K90382497_-666_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCF7_Meprednisone_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155939 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K38131403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31308 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K21680192_mitoxantrone_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r4 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40398 K562_IOX2_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162712 BRD-K35404627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45256 SK-MEL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.87914 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD51C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00381192 Disease Models, Animal CTD Gene-Disease Associations 1.0 1.08904 QKI LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00618208 MAFF ENCODE Transcription Factor Targets 1.0 null VCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5716 SKMM2 CCLE Cell Line Gene CNV Profiles 1.0 1.45935 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE225218_0_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K90382497_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066842 cd4.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.863529 hsa-miR-3647-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.265648 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.67466 BRD-K75576005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.72137 SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58428 K562_Pirarubicin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176381 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Common variable immunodeficiency 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.439 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.47932 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56947 GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19511 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null CADM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00529735 H3K36me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34533 GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.15289 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 SIN3A-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HPS6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00517268 SERPINB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00551714 nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.176434 Nr2f6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 48.7598 KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE210885_3_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K40738002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52795 pentamidine-2834 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20539 GTEX-X4EO-2926-SM-4E3JH GTEx Tissue Sample Gene Expression Profiles 1.0 0.875362 CRCGN017_MCF10A.WT.HP_24H:K24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7222 GSE142588_2_v_0_cinobufagin_human RummaGEO Drug Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.69001 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_Selisistat_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0153054 SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66831269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01813 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K27638063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.328 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04473 PDCD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.71534 Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K99387963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06418 BRD-K86988191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89668 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRR14L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00489577 GTEX-XAJ8-0126-SM-47JYG GTEx Tissue Sample Gene Expression Profiles 1.0 2.0147 CXXC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00645467 BRD-K19435356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04398 IWR-1 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.22 PMVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14946 abducens motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33168 BRD-K99038919 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44159 BRD-K79833963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08011 Saracatinib DeepCoverMOA Drug Mechanisms of Action 1.0 0.87 CRCGN015_HEPG2_48H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.46465 GTEX-WHPG-2626-SM-3NMBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.04963 Perturb_16466_KO_Tnfsf12_SRP102352 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.83807 proliferative GeneRIF Biological Term Annotations 1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.577106 MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03382 TCF12_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859371 Inflammatory bowel disease GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.1699 BRD-K22485581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25152 CMTM7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0056173 BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_EFO27_6.0_h_0.63_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13133 MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.904677 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.30788 K562_GSK-LSD1 2HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0497806 DOHH2 CCLE Cell Line Gene Expression Profiles 1.0 1.51357 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null clorsulon-7025 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X3Y1-2026-SM-3P5YM GTEx Tissue Sample Gene Expression Profiles 1.0 0.936236 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 6862_PSMC5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.593741 protein localization GO Biological Process Annotations 2015 1.0 null HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25553 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null M14 BioGPS Cell Line Gene Expression Profiles 1.0 1.27226 GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles 1.0 2.73815 Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.7931 MEC1 DepMap CRISPR Gene Dependency 1.0 2.8636 CRCGN015_MCF10A.TP53.M_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.11355 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superior periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01772 Epithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K52202153 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06566 BRD-K57476199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16364 H3K27ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.867144 H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_5_CXCL10-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null piperine-3263 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE176008_4_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0591 GTEX-XAJ8-0826-SM-47JY6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09438 GATA6-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 2419_DXO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514482 BCL11A ENCODE Transcription Factor Targets 1.0 null 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10476 PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null meclocycline-3277 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NLRP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00591888 EFM-19 COSMIC Cell Line Gene Mutation Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-Q3-A5QY-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE247862,GSE247863_0_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K57972271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6594 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24273 basolateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.48963 GM2493 BioGPS Cell Line Gene Expression Profiles -1.0 -2.85251 GTEX-S33H-1326-SM-4AD6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.11782 RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.9687 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04909 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null induseum griseum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05767 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCDC134 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00510936 Perturb_205_KD_Robo1/Id1/ld3_SRP193147 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.71155 Dopaminergic A13 group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03302 TAL1_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null ASAP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.623 Taenia tecta, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71385 MAP3K5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00493612 PMC4113144-1476-4598-13-64-S5.xls-IRF1_exon_good-Unnamed_1_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null CORL23_LUNG CCLE Cell Line Proteomics 1.0 2.17373 Palonosetron DeepCoverMOA Drug Mechanisms of Action -1.0 -0.44 benfluorex-2621 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08561 GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 2.21401 MAX::MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1429 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prestwick-1100-4356 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nalidixic acid-2297 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.998747 hESC_Derived_CD184+_Endoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.83417 RFX7 NURSA Protein-Protein Interactions 1.0 0.081964 cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17449 Substance dependence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 GSE201309_1_v_6_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845008 ZNF768 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2371 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02942 KYSE520 DepMap CRISPR Gene Dependency 1.0 5.2115 ZPBP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00642123 mammary gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYP11A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00623636 PPP6C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00724424 GSE146074_10_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.030562 BRD-K52017042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22368 Perturb_13556_OE_Smyd3_SRP223218 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 19.3979 WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null 16p11 2 distal deletion syndrome WikiPathways Pathways 2024 1.0 null NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36202 RABEP1 Pathway Commons Protein-Protein Interactions 1.0 null SRF ENCODE Transcription Factor Targets 1.0 null GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K71007902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09384 hsa-miR-3591-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.140752 GSE226584,GSE226589_2_v_0_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042545 PPIH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28299 digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.361527 Perturb_284_KD_GABPA_SRP303690 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K39962926 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20859 HC-01-FD24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.383591 GTEX-U3ZN-2326-SM-3DB7W GTEx Tissue Sample Gene Expression Profiles 1.0 1.31473 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.308 ANKRD13D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33042 BRD-K25177502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83398 K562_Raltitrexed_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.027622 CRCGN016_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1019 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K41102088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11472 MCF7_Iniparib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0239416 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4JB-01A-51R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171837_0_v_3_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20148 Idiopathic Membranous Glomerulonephritis DisGeNET Gene-Disease Associations 1.0 null antazoline-6775 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE173262_2_v_0_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null BL9456 (CRY2) NURSA Protein Complexes 1.0 null USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BL1074 (AURKB) NURSA Protein Complexes 1.0 null BRD-K37062347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.54241 BRD-M30523314_V2264_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.7338 intermediate stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13566 RAB5A Pathway Commons Protein-Protein Interactions 1.0 null ticarcillin-7185 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.831188 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K53561341_KIN001-220_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE86507,GSE86509_3_v_2_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZGLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09025 BRD-K73775927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37698 Obesity DisGeNET Gene-Disease Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4375 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_AMG-900_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0107136 r10 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73675 GP5D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NANOG-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null outer CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1941 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLXNA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00752803 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74545 BRD-K92317137_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CAPN15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00842106 K562_Motesanib Diphosphate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162962 Edema CTD Gene-Disease Associations 1.0 1.2772 GSE158834_11_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.273 BRD-K69569958 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21707 hsa-miR-125b TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 GTEX-QDT8-0011-R6A-SM-32PKI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858052 BRD-K16154498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89924 Lung adenocarcinoma_LUAD_TCGA-73-4675-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21683 CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CACNG3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00911778 UACC812 CCLE Cell Line Gene Expression Profiles 1.0 1.89568 GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.45177 SCN9A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0060334 PLEKHA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17456 Blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.43233 GSE142210_2_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 CRCGN015_MCF10A.WT.HP_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.02103 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGI-6780 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1831 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9088 LASV_FML29 _4hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.91106 GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30791 GSE158834_11_v_3_palm_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K81651477_Parthenolide_CORL23_6.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE147876,GSE147877_4_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Busulfan_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149555 BRD-K99380757 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36129 primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23865 GSE171292_6_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.025388 TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-0126-SM-4DM6K GTEx Tissue Sample Gene Expression Profiles 1.0 1.34724 PHA-00745360-4559 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null TAL1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null cisplatin_homo sapiens_gpl570_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K12260399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11949 Perturb_8015_KD_Crebl2_SRP214573 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.34774 MCF7_Thiotepa_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153993 BACH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0054954 molecular function regulator GO Molecular Function Annotations 2015 1.0 null GSE139992_1_v_0_mboat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null MS4A15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0076035 H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K79908599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56288 pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.393473 RFX5 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6988-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A07944983 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41538 ZNF24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.993 AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BACH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.1591 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06765193_5663823_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bosentan DeepCoverMOA Drug Mechanisms of Action -1.0 -0.63 GSE224877_2_v_1_pctp_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_11772_KO_18O10Rik_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.65739 MET_knockout_261_GSE8747 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.05762 GTEX-XMK1-1726-SM-4B64Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.841677 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953715 BRD-K33897007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28315 GSE201110_0_v_1_sirt4_human RummaGEO Gene Perturbation Signatures 1.0 null r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87677 H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40282027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0587 SW948 COSMIC Cell Line Gene Mutation Profiles 1.0 null H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Septohippocampal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01894 WM1799_SKIN CCLE Cell Line Proteomics 1.0 3.19065 KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.354816 tremorine-1579 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K64268886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55933 SP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.885155 GTEX-XUW1-0926-SM-4BONX GTEx Tissue Sample Gene Expression Profiles 1.0 1.07467 CRCGN015_MCF10A_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3012 FBXL19 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0053052 AMY2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00661238 TMUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46346 paraventricular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02534 TBP ENCODE Transcription Factor Targets 1.0 null H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null STAC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00818625 GTEX-NFK9-0226-SM-2HMKQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.63214 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PSG7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00997758 PMC7884075__F4 PFOCR Pathway Figure Associations 2024 1.0 null RAJI CCLE Cell Line Gene Expression Profiles 1.0 1.35289 AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203792 LNCAPCLONEFGC CCLE Cell Line Gene Expression Profiles 1.0 1.63223 GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890395 GSE222598_1_v_0_sf3b4_human RummaGEO Gene Perturbation Signatures 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919392 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null TAL1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NKX2-5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00752753 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54695 GSE147876,GSE147877_4_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K06685815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64067 VSTM2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00668314 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TSC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00811082 GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06441 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17307 ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.4505 HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11344 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SETD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00426231 BRD-K30269093 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24034 COPS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45468 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K4-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4EP-0126-SM-3P5YV GTEx Tissue Sample Gene Expression Profiles 1.0 0.902725 outer CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26925 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37294 Perturb_9504_KO_Il33_SRP076391 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -17.567 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91056 GTEX-OIZH-0926-SM-48TBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.58921 cingulate gyrus, parietal part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.67894 Perturb_11053_Mut_Lmna_SRP309326 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.96856 GTEX-XUW1-0426-SM-4BOOT GTEx Tissue Sample Gene Expression Profiles 1.0 1.1195 GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K92134254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19653 BRD-A39996500_radicicol_HME1_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superficial stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2849 Perireunensis nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27556 NCIH838 DepMap CRISPR Gene Dependency 1.0 2.55312 PFEIFFER CCLE Cell Line Gene CNV Profiles 1.0 1.42902 Carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sildenafil DeepCoverMOA Drug Mechanisms of Action 1.0 0.42 PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8 Rummagene Transcription Factor Associations 2026 1.0 null GRM3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00615312 NRF1 ENCODE Transcription Factor Targets 1.0 null BRD-K71139459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33452 CES1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00869291 GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07432 A549_Prednisone_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164888 ABCB9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00532393 LCP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00479193 GSE77108_0_v_2_saha_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40185 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Secondary motor area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27628 GSE242521,GSE242522_0_v_1_mettl3_human RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40398 NTRK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00576655 3871_HNRNPL_P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.632714 NCS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00952471 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149943_2_v_0_cd8a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE207914_0_v_6_nudt7_mouse RummaGEO Gene Perturbation Signatures -1.0 null ChIP_SIN3A_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null AKR1C2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00608304 IGFBP4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00697705 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.30574 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.95677 MAX_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-A4SU-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33231 GSE158834_11_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K76023734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2489 GSE144231_4_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC12480102-41525_2025_515_MOESM2_ESM.xlsx-ST12-Unnamed_3_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null PMC3728595-srep02327-s1.pdf-25-SPIB_SPIB Rummagene Transcription Factor Associations 2026 1.0 null BRD-K69229416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30554 GSE193258,GSE193259_9_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null STAT3-19079543-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K75074041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72009 RELA ENCODE Transcription Factor Targets 1.0 null gramine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54715 BRD-K10027041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21158 GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63676 NCI-H2009 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HNF4 MotifMap Predicted Transcription Factor Targets 1.0 null Perturb_2891_KO_Pgrmc2_SRP175165 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.79706 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6472-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHMP1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0057951 Perturb_16316_KD_POU2AF1_SRP336261 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE57871_8_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18456 BRD-A79465854_auranofin_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11694 NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218827 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MF-01A-12R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K70712582 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05024 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41822 GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928062 EW8 DepMap CRISPR Gene Dependency 1.0 2.75579 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00401 PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911482 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ciliary base COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.834 GSE158834_11_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_12523_KD_Linc00673_SRP212104 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 vagina HPA Tissue Protein Expression Profiles -1.0 -1.12523 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.759469 K562_Fasudil_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153711 LCP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00706101 GATA1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17593 NR2F2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95648552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3703 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CORL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.55248 E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34706 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.69576 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GM2313 BioGPS Cell Line Gene Expression Profiles -1.0 -1.01021 TMEM175 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00643182 LY-294002-5576 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2 JASPAR Predicted Transcription Factor Targets 1.0 null NIHOVCAR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.7529 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21638 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03382 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTNNB1 ChEA Transcription Factor Targets 1.0 null BRD-K64404450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02782 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1153 HCC364 CCLE Cell Line Gene CNV Profiles -1.0 -1.96285 Perturb_4368_KO_Peg10_SRP167954 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.2561 Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02339 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.918136 BL436 (NCOA2) NURSA Protein Complexes 1.0 null EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08482 VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE ChEA Transcription Factor Targets 2022 1.0 null SAA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00719505 ALK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00449482 FE-64-KC49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.575045 GTEX-WHSB-1326-SM-3LK6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.42534 MERCK544 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 A549_Streptozotocin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175657 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38943 Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3081 Guanosine triphosphate HMDB Metabolites of Enzymes 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE224004,GSE224005_0_v_8_chd4_human RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:K24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66389 XRN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00925311 GSE98964_1_v_4_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UJMC-1326-SM-4IHLS GTEx Tissue Sample Gene Expression Profiles 1.0 0.911708 Minocycline DeepCoverMOA Drug Mechanisms of Action 1.0 0.32 GSE169356_2_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.245 GSE242647_2_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OHPN-0011-R1A-SM-2I5GB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892268 GATA2-19941826-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE186647,GSE217287_1_v_3_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.51073 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DYNC1LI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12234 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A55594068_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Leukemia, Chronic T-Cell_T lymphocyte_GSE5788 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.03993 BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K20755323_-666_CORL23_6.0_h_40.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.615325 hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28366 GSE174498,GSE174500_5_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPS19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27729 GSE183413_1_v_2_ash1l_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K82126187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81595 Perturb_18008_Mut_Card14_SRP260070 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.749 JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.847375 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A27056524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0251 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG-16518401-CHIP-PET-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null WC-33-YP46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202929 sulfametoxydiazine-3453 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null B2M LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00519068 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SMG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00639565 Moyamoya disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.273 RHJT DepMap CRISPR Gene Dependency 1.0 3.24032 BRD-K80467627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8186 TMX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70805 EPHB2_drugactivation_228_GSE26523 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.70623 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFE2 ENCODE Transcription Factor Targets 1.0 null CDC42BPG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00552171 excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null intermediate part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02001 CRCGN017_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.76541 Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 R3HDM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35021 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20764 HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00382 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.98742 GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00823 AURKA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00639861 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.98151 superficial dorsofrontal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4244 Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FASN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34861 Tanomastat DeepCoverMOA Drug Mechanisms of Action -1.0 -0.42 Bardet-Biedl syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 GSE211128_3_v_5_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8479-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSMD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00695634 FOXA1-25552417-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null increased body weight GWASdb SNP-Phenotype Associations 1.0 1.26545 GSE60691_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GFI1B ChEA Transcription Factor Targets 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null KIFC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60945 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.86394 GTEX-XPVG-2526-SM-4B66D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09054 NCCIT Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.7554 GSE196117_6_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null RAB1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60875 GTEX-S4Z8-0126-SM-4GICC GTEx Tissue Sample Gene Expression Profiles 1.0 0.898196 propylthiouracil-2837 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null Lymphnode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.2683 CRCGN015_MCF10A.TP53.M_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88345 MCF7_Tozasertib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157347 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Bisindolylmaleimide IX_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140692 MCF7_Tofacitinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0185154 muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ENTREP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5585 CRYBG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00492 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DFFA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0036143 CRCGN014_HEPG2_3H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.10592 BRD-K94082609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34445 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205976,GSE205978_1_v_4_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null econazole-2396 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38359 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3337 Perturb_7505_OE_ADARB1/ILF3_SRP195616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.14431 GSE60837_2_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYLK4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00745012 Perturb_13551_OE_Smyd3_SRP223218 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.0492 BRD-K26233698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20042 PDE1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00829376 r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44055 SOX11_DEPLETION_GDS4801_326_human_Z138 mantle cell lymphoma (MCL) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE234340_10_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBR7_KD_significant-Unnamed_23_AR Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null X31(H3N2)_12hour_None_GSE37245 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.28726 RAD17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24303 Perturb_13575_KO_lnc31_SRP114676 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.75898 substance-related disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 AU565 CCLE Cell Line Gene Expression Profiles 1.0 1.67994 CDCA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23171 progesterone-3287 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null zaprinast-3226 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_Valproic acid sodium salt_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146057 Lung squamous cell carcinoma_LUSC_TCGA-60-2721-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K71262871 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22787 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.465103 NUTM2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00908786 BRD-K87404495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.39595 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12137_OE_Wdr11_SRP113332 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.1584 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null endosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.69058 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84127 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13647 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.827194 Cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11341 Cerebral artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.534 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null KCNK10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00539232 GSE199874_4_v_5_gabpb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Macropinosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.809 GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46526 BRD-K90003650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08826 BRD-K05269173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.95216 Taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43176 EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTNNBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10245 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Resveratrol_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015263 Perturb_3202_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.91913 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3537_KD_HNRNPK_SRP355083 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.51226 BBSome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.969 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA2_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUPT7L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00585729 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55483 MCF7_Alvespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0122871 brownfat BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.08366 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.828267 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00825748 SkeletalMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.886634 CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSK3A_knockdown_207_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.48038 r6 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08561 Non-Small Cell Lung Carcinoma DisGeNET Gene-Disease Associations 1.0 null HS294T DepMap CRISPR Gene Dependency 1.0 5.69638 H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47W-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24273 LY-294002-5596 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H810 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K95485901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09037 H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948269 OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16123 KIAA2013 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16293 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44011 GSE193751_1_v_3_oridonin_human RummaGEO Drug Perturbation Signatures -1.0 null Ciliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.429 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRY-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_17465_KO_Jun_ERP124420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.49688 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0043 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40259 MCF7_ENMD-2076 L-Tartaric acid_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0118486 K562_KW-2449_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140656 Perturb_12542_KO_ADAR_SRP194087 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.2765 K562_Alisertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189266 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE152441,GSE152442_6_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55F-0126-SM-48FCK GTEx Tissue Sample Gene Expression Profiles 1.0 1.05754 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null BC-3 GDSC Cell Line Gene Expression Profiles 1.0 1.68326 GTEX-XMK1-0226-SM-4B65D GTEx Tissue Sample Gene Expression Profiles 1.0 1.35737 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 IFIT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00965126 Sorting endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.784 BRD-K51858914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48411 KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K88378636_withaferin-a_LNCAP_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K23363278_CYT997_MCF7_24.0_h_1.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K95501793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.54742 Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50942 GTEX-SNMC-0926-SM-4DM5U GTEx Tissue Sample Gene Expression Profiles 1.0 3.42071 GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02709 KAT2B ENCODE Transcription Factor Targets 1.0 null BRD-K50168500_canertinib_SKBR3_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_1382_KO_Sdc1_SRP286584 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.27698 Vagina GTEx Tissue Gene Expression Profiles 2023 1.0 2.27325 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles 1.0 1.89871 GSE198982,GSE198986_1_v_2_daunorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2416 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X88G-0126-SM-47JZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44053 GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 0.938613 Anterior cingulate area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15006 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Carbamazepine DeepCoverMOA Drug Mechanisms of Action 1.0 0.33 NCIH1581 CCLE Cell Line Gene CNV Profiles -1.0 -1.46419 YY1_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_YM155_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0217017 YMB1 CCLE Cell Line Gene Expression Profiles 1.0 1.46873 GTEX-XUZC-1426-SM-4BRV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.882874 YAP1 ChEA Transcription Factor Targets 1.0 null KNG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00601601 BICR16 DepMap CRISPR Gene Dependency 1.0 2.84389 BRD-K99728124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00494 K562_Zileuton_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0249115 H3K9me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K90526956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20289 Primary motor area, Layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46565 Perturb_12074_OE_Carm1_SRP134253 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.56922 MCF7_XAV-939_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168686 CRCGN015_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.11937 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null KYSE510_OESOPHAGUS CCLE Cell Line Proteomics 1.0 2.17373 H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.865275 GTEX-XV7Q-2926-SM-4BRUL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06643 PMC7884075__F4 PFOCR Pathway Figure Associations 2023 1.0 null BRD-K27008344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13741 CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42373 positive regulation of biological process GO Biological Process Annotations 2015 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44716 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82088 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54834 Undecanoic acid DeepCoverMOA Drug Mechanisms of Action -1.0 -0.37 6-azathymine-2827 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.17246 liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.59627 ABHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38168 Nephronophthisis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.104 CD247 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00773448 KDM2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00547716 BRD-K34590335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17624 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54235 BRD-K91784140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06131 GSE147876,GSE147877_4_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null NINJ1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00578456 BRD-K63111122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13624 USF2 ENCODE Transcription Factor Targets 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.27445 19074828-TableS4 GeneSigDB Published Gene Signatures 1.0 null ZR751 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.699439 BRD-K15387690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05883 SPIB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00804914 H3K79me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dapiprazole DeepCoverMOA Drug Mechanisms of Action -1.0 -0.21 BRD-K54837058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00456 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.90235 BRD-K29838935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46516 GSE202933_1_v_0_ugt2b28_human RummaGEO Gene Perturbation Signatures 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.71774 Perturb_16359_OE_Ppargc1a_SRP278337 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.2924 positive regulation of molecular function GO Biological Process Annotations 2015 1.0 null MEOX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0071549 RNASEH2C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00707159 UE-02-UW61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266423 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null JAK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00604498 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.885157 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K87742870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37349 acquired metabolic disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.544585 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.70124 LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.53083 flucloxacillin-5102 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K64890080_BI-2536_HCC515_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CLEC1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0103145 BRD-K35727000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08908 Perturb_17358_KO_Tcf7l2_ERP119729 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.3047 demecarium bromide-2773 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SW1990 COSMIC Cell Line Gene Mutation Profiles 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null Prelimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1939 Lung adenocarcinoma_LUAD_TCGA-62-A46P-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null early endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.561358 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ATG4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28472 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4443 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K92359570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00618 MHHCALL4 CCLE Cell Line Gene Expression Profiles 1.0 1.5601 PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC Rummagene Transcription Factor Associations 2026 1.0 null MEF2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R6A-SM-3DB7L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02199 TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100626_FWM_no dementia_TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03285 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.992189 GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.885888 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21818 GTEX-XPVG-2626-SM-4B669 GTEx Tissue Sample Gene Expression Profiles 1.0 0.930023 GSE102675_2_v_1_atf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null organelle GO Cellular Component Annotations 2015 1.0 null Perturb_15859_KD_EHMT2_SRP267073 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.7884 Perturb_17721_KO_Mbnl1_SRP014709 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046273 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K33379087_tivantinib_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17565 Lung adenocarcinoma_LUAD_TCGA-50-8460-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-0226-SM-4AD5K GTEx Tissue Sample Gene Expression Profiles 1.0 1.34338 BRD-K22308901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46765 GSE171572_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null FOXO3 ChEA Transcription Factor Targets 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chromosome 16p11.2 deletion syndrome, 593-kb DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.072 theobromine-4958 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STING1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00563736 PK8 DepMap CRISPR Gene Dependency 1.0 2.91841 WDHD1 Pathway Commons Protein-Protein Interactions 1.0 null GSE103297_1_v_0_glis3_mouse RummaGEO Gene Perturbation Signatures 1.0 null SELE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00773284 GTEX-WFG8-1326-SM-4LVN3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05891 GSE164463_2_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T8EM-1826-SM-4DM7F GTEx Tissue Sample Gene Expression Profiles 1.0 1.66521 TOP2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00740532 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65182930_NVP-AUY922_HEPG2_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KASUMI1 DepMap CRISPR Gene Dependency 1.0 2.04719 3447_GNL3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.11618 GSE76425_0_v_10_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 4.33401 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5462_NAPA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.563865 JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_SRT2104_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148412 periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27334 H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94378 LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07046 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 BRD-K96258717 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23106 factors GeneRIF Biological Term Annotations 1.0 null SYK_druginhibition_285_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.29636 SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.867597 BRD-K62659610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07025 Perturb_2896_KO_Ghrh_SRP241951 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.19091 ritodrine-2635 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CYP3A7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00724372 GTEX-SN8G-0526-SM-32PLE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838126 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 1.55246 Sarcoma_SARC_TCGA-K1-A6RU-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Azacitidine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0225545 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.4338 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null 11823860-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null GSE135030_3_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null TE6 DepMap CRISPR Gene Dependency 1.0 2.22446 ChIP_POU5F1_16518401 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11214 GTEX-WRHU-0926-SM-4E3IG GTEx Tissue Sample Gene Expression Profiles 1.0 0.853932 H4K91ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autism DisGeNET Gene-Disease Associations 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RASAL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00714379 K562_Azacitidine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149389 GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.48719 BRD-A19500257_geldanamycin_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCF7_Andarine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143975 HS 895.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.55012 LARP7 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K22839533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15938 MCF7_BRD4770_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171146 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DLL4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00812205 CTNNB1-20460455-HCT116-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Orofaciodigital syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.271 BRD-K13044705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23614 Perturb_16403_KO_Grpel1_SRP363877 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.9004 ZNF143 ENCODE Transcription Factor Targets 1.0 null GRANTA519 CCLE Cell Line Gene Expression Profiles 1.0 1.8031 BRD-K63188051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8369 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16886 POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K07160586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59011 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862598 BRD-A55484088_BNTX maleate_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE77108_0_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null MAX LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0100825 BRD-K30772101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43223 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040489 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12393 BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.906117 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879124 GTEX-WRHU-2826-SM-3MJG8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00954 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7631-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC16A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00393442 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.9228 GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5459 BRD-A94420133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22674 NR2C1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00501923 GSE203017_0_v_1_irs2_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3728595-srep02327-s1.pdf-1624-ARID3A_ARID3A Rummagene Transcription Factor Associations 2026 1.0 null ABCA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00702792 HEB MotifMap Predicted Transcription Factor Targets 1.0 null H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXO3-22982991-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K9me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null spironolactone-5781 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNASEH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6517 tiapride-3663 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null Infralimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40924 GTEX-R55G-2526-SM-2TC6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.890976 BRD-K94476572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01697 GSE189653,GSE203344_4_v_3_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_13046_KO_Gprc5a_SRP115526 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.30147 liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.38437 GTEX-OXRN-0011-R5A-SM-2I5EF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21717 BRD-K72533381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34402 NP8 DepMap CRISPR Gene Dependency 1.0 4.35555 FPGS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00391219 liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.76806 GSE234340_1_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NHP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00572548 PRKCE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00691475 NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52452 BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null t99-vena-cava_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.59534 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.843633 BRD-K47951859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90469 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QVJO-0126-SM-3GIK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40408 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1839 GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08605 K029AX DepMap CRISPR Gene Dependency 1.0 2.42213 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE220520_3_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K61315077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15554 BRD-K35724671 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12865 CRCGN016_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.48163 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K86623758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59721 Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88639 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.440246 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null adrenalgland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.10661 GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 0.918695 GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null A549_INO-1001_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177777 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K38650960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8305 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.32093 POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOXIMVI_SKIN CCLE Cell Line Proteomics 1.0 2.09145 supramarginal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.900057 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.869621 CAL-148 COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902517 BRD-K21327356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12251 PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P44H-0011-R4A-SM-2XCEW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01269 ambroxol-3238 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44224 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08201 GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.08589 Rabaptin-5beta InterPro Predicted Protein Domain Annotations 1.0 null etomidate-2958 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SRF_SRF Rummagene Transcription Factor Associations 2026 1.0 null SPTA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00990037 H3K9me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Cervix - Ectocervix GTEx Tissue Gene Expression Profiles 2023 1.0 1.63357 BRD-K26461918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14606 Perturb_4678_KO_Dppa2/Dppa4_SRP218369 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.87329 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.89634 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1467 Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LBX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29018 GSE149264,GSE149267_2_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Avagacestat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169592 GTEX-XAJ8-0526-SM-47JYK GTEx Tissue Sample Gene Expression Profiles 1.0 1.32262 SNU668 CCLE Cell Line Gene Expression Profiles -1.0 -1.52237 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K66838902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67612 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10677 ETS1 ENCODE Transcription Factor Targets 1.0 null spleen GTEx Tissue Gene Expression Profiles 1.0 1.33576 UBE2L6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05209 Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RFX5 (RFX5) NURSA Protein Complexes 1.0 null BRD-K79204912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47087 BRD-K29756429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20726 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE244233_1_v_0_quercetin_human RummaGEO Drug Perturbation Signatures -1.0 null 3916_HOXC6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.505175 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.440425 PDE8A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00711027 BRD-K47821225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93103 Sox17 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.2446 plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K60543885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50054 GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01615 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40218 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23179 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.204 posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.936374 KARPAS-620 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.42649 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11214 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Deficiency Of Glucose-6-Phosphate Dehydrogenase DisGeNET Gene-Disease Associations 1.0 null TIPIN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00792714 NLRC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00486649 ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-1826-SM-4B64X GTEx Tissue Sample Gene Expression Profiles 1.0 1.0546 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28011 H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12393 BRD-K80359388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1524 CRCGN015_MCF10A_48H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20065 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.836957 BRD-K56536691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25782 GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7966 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K99964838_S1014_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW1710 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.58909 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61353 SF539 BioGPS Cell Line Gene Expression Profiles 1.0 1.59694 Disease of metabolism DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.202 Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.845602 hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.22412 Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null proglumide-2363 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.38552 FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.596094 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.67049 Gastrointestinal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.273 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMK1-0126-SM-4B65F GTEx Tissue Sample Gene Expression Profiles 1.0 2.08056 BRD-K44497547 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4378 BRD-K76175734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01931 BE-38-UW72_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201096 CKMT1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.011738 HEC50B CCLE Cell Line Gene CNV Profiles 1.0 1.7923 a-Mip1 () NURSA Protein Complexes 1.0 null orbital frontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.825852 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_15871_KO_PAX3/FOXO1_SRP293781 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 18.041 Liver cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27041 estradiol-4432 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DPP9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00523553 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null sulfathiazole-1463 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.07215 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUTU-80 COSMIC Cell Line Gene Mutation Profiles 1.0 null cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19125 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.54206 Crohn's disease GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.952288 H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61466 BRD-K70511574_sunitinib_MCF7_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29143 H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Spleen Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.92156 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.817 layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.882017 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE203308_14_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 20436685-ST4-2 GeneSigDB Published Gene Signatures 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13932 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null valproic acid_homo sapiens_gpl570_gse14973 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11926 Primary Malignant Neoplasm Of Lung DisGeNET Gene-Disease Associations 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K36468214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3605 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.33052 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null PMC3443648-1752-0509-6-89-S1.xls-Sheet1-NFYA_NFYA Rummagene Transcription Factor Associations 2026 1.0 null doxorubicin-5671 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A549_Divalproex Sodium_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0173516 PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521 Rummagene Transcription Factor Associations 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42966 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE141143_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OIZI-0526-SM-2XCEG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860639 GTEX-UPJH-0226-SM-3GADV GTEx Tissue Sample Gene Expression Profiles 1.0 0.992818 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.273 MDAMB453 CCLE Cell Line Gene Expression Profiles 1.0 2.0751 Perturb_13532_KO_Mbnl3_SRP103934 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.67365 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null biological regulation GO Biological Process Annotations 2015 1.0 null BRD-K41172555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2261 DD-74-PJ26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210506 Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22759 Dorsal peduncular area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66045 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7723 PIK3R6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.006687 Perturb_15613_Mut_Dmd_SRP329695 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.00924 Hepatoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 LS123 CCLE Cell Line Gene CNV Profiles 1.0 1.94132 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.848251 lateral orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.864495 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02881 ETS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0069971 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.15245 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Orbital area, medial part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66242 K562_Cediranib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177721 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.29867 K562_G007-LK_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158425 CD34 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00591677 SNU398 CCLE Cell Line Gene CNV Profiles 1.0 1.58747 BRD-K73523821 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12712 methazolamide-5794 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K73182084 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89438 Pyogenic Arthritis, Pyoderma Gangrenosum And Acne DisGeNET Gene-Disease Associations 1.0 null GSE112174_5_v_7_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 9909_XRCC6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.560521 Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.910448 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-0126-SM-4DM6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.971343 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.45073 BRD-K98145661 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81663 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BL8118 (HTATSF1) NURSA Protein Complexes 1.0 null BRD-K58643762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26527 WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209571 GTEX-POMQ-0126-SM-48TD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45382 CD105+_Endothelial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.899924 Waist circumference adjusted for body mass index GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.769897 Body Mass Index DisGeNET Gene-Phenotype Associations 1.0 null CD274 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00703988 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4663 TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 GTEX-XBEW-0126-SM-4AT66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.980046 pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.985125 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null adenocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K53971345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31482 NUGGC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00721571 GSE130401_4_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88382 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00439669 BRD-K17649115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36453 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866799 SIN3B ChEA Transcription Factor Targets 1.0 null K562_Tubastatin A HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.03467 SLAMF9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00625094 BRD-K15322427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.73832 K562_Costunolide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153279 CRCGN008_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.92247 Lung adenocarcinoma_LUAD_TCGA-49-4490-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.831217 GTEX-PWN1-0126-SM-2I3FK GTEx Tissue Sample Gene Expression Profiles 1.0 0.846287 BRD-K75451592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30706 TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231720,GSE231724_2_v_0_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null positive regulation of gtpase activity GO Biological Process Annotations 2015 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Idiosyncratic drug effect_Hepatic Tissue_GSE2825 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.35407 G28T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01015 H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XUZC-0226-SM-4BOO7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.897138 GW 3965 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.56 sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_16084_KO_Nfya_SRP270915 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 tamoxifen_homo sapiens_gpl3921_gse33366 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XOT4-0626-SM-4B66L GTEx Tissue Sample Gene Expression Profiles 1.0 1.37714 H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 86.7595 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.831217 nes HPA Cell Line Gene Expression Profiles -1.0 -1.09195 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.898853 GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles 1.0 2.61143 RELA_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MIA-PaCa-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.73203 fra1 GeneRIF Biological Term Annotations 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WXYG-2026-SM-4E3IY GTEx Tissue Sample Gene Expression Profiles 1.0 0.988402 hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.889963 RCOR1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF274 ENCODE Transcription Factor Targets 1.0 null posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.871417 Ciliary basal body COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null BRD-K08233096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22056 ethotoin-3809 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A549_Nilotinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130326 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRN-2426-SM-2I5EQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07305 Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTPN14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00588446 Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21556 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BL4172 (NCRNA00153) NURSA Protein Complexes 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.4926 BRD-K09721867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11839 r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14261 GSE151829,GSE151831_1_v_0_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null Finding Of Body Mass Index DisGeNET Gene-Phenotype Associations 1.0 null Perturb_14134_KO|OE_Dnmt3a/Dnmt3b|Kdm4b|Kdm5b_SRP151021 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.6742 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.995613 fulvestrant-5202 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4433 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 prostate HPA Tissue Gene Expression Profiles 1.0 1.08728 496100347_PCx_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.86659 K562_UNC0379_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161498 GTEX-V955-0126-SM-4JBH5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12749 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE234340_1_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null LS-180 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38123 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_10845_KO_Xbp1_SRP197108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.75536 nutrition disease GWASdb SNP-Disease Associations 1.0 0.47932 BRD-K81318113 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69908 BRD-K39087168 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47514 WHSC1 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829074 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K29178949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09894 GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 0.923904 BRD-K00509345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.003 KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.4698 RXRA ENCODE Transcription Factor Targets 1.0 null WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.95122 UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K68605096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15813 MAK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00541882 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ENTHD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00477401 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 7038_RAB6A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.527237 CORO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16864 Lung squamous cell carcinoma_LUSC_TCGA-90-7964-01A-21R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tafluprost DeepCoverMOA Drug Mechanisms of Action -1.0 -0.27 CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08194 methyldopate-4986 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE202434,GSE202438_4_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null OCILY18 DepMap CRISPR Gene Dependency 1.0 4.29723 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K11674021 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09562 ethotoin-2196 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF274_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114013,GSE114014_0_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null BCL7C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00564408 GSE169356_2_v_4_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 HT-144 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03135 PECAPJ41CLONED2 DepMap CRISPR Gene Dependency 1.0 3.83033 BRD-K42392619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06743 GSE207787_3_v_2_pdha1_human RummaGEO Gene Perturbation Signatures -1.0 null GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21804 Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hip index GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.809691 L-Mimosine DeepCoverMOA Drug Mechanisms of Action 1.0 0.25 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80829 GTEX-P4QT-1426-SM-3NMCX GTEx Tissue Sample Gene Expression Profiles 1.0 0.870266 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K11846531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28755 KLF12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00575696 HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.270298 MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05374764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43658 Prostate BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.54233 ChIP_REST_18959480 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null K562_Ruxolitinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162163 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.79638 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.260904 BL3434 (CRTC1) NURSA Protein Complexes 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null NR3C1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K88590066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43173 Ciliary landscape WikiPathways Pathways 2024 1.0 null BRD-A43330902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.24027 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.92425 CHP126 CCLE Cell Line Gene Expression Profiles -1.0 -1.88492 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null TE4 DepMap CRISPR Gene Dependency 1.0 3.99159 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.7957 SW620_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 2.42175 FB-49-NW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.381075 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76401790_JNK-IN-5A_PC3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16743 Cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Perturb_15612_KO_Net39_SRP273304 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.6809 LUDLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.54849 GTEX-XXEK-0126-SM-4BRVU GTEx Tissue Sample Gene Expression Profiles 1.0 2.62848 TEAD4 ENCODE Transcription Factor Targets 1.0 null BRD-K39695412 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00666 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DVL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00718753 4129_INO80E_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.05215 TRPC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00618453 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123836_2_v_3_myf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE185519_1_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cefaclor-2843 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U4B1-0526-SM-4DXTK GTEx Tissue Sample Gene Expression Profiles 1.0 1.35097 Perturb_1126_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.33286 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88148 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4G ENCODE Transcription Factor Targets 1.0 null PROC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00526056 Indomethacin DeepCoverMOA Drug Mechanisms of Action -1.0 -0.28 K562_BMS-911543_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154273 ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_3536_KD_HNRNPK_SRP355083 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.62331 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_9_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Baricitinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155497 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0526-SM-3NMD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1619 BRD-K47409867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88321 Perturb_10587_Mut_Tbx5_SRP306874 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.48768 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-0126-SM-48TBW GTEx Tissue Sample Gene Expression Profiles 1.0 1.08781 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53601 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2B Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64952 BRD-K30214140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06025 BRD-K61363662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.39408 NEPRO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1491 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.177029 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89062 pentoxyverine-2623 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09069 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21867 GSE151494_8_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NB-61-FT12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.226671 Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46565 SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55692 GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33389 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymph_Node-b cell Tabula Sapiens Gene-Cell Associations 1.0 11.817 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RHOV LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00591686 cinoxacin-5783 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-3160-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.404082 AD-86-ES28_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278427 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.62716 GTF2F1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.44798 PAPSS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00516104 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMZS-0126-SM-3DB9Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.07634 GTEX-QEG4-0226-SM-2S1PY GTEx Tissue Sample Gene Expression Profiles 1.0 1.09023 BRD-K43375231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34625 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41823 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM126A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05339 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874172 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.964291 suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.80938 CRCGN016_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.80556 Trunk TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29557 GSE178714_3_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null CLCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07412 cell part GO Cellular Component Annotations 2015 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05835 GSE261177_0_v_1_tnfrsf12a_human RummaGEO Gene Perturbation Signatures 1.0 null UCN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00432378 WRNIP1 ENCODE Transcription Factor Targets 1.0 null SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66316 INS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00598145 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DP-agonist13 DeepCoverMOA Drug Mechanisms of Action 1.0 0.25 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5-R-Rivaroxaban DeepCoverMOA Drug Mechanisms of Action -1.0 -0.4 layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66045 BRD-K61092554 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84971 GSE225218_9_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19312 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148252_1_v_6_npas4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5010-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE77108_4_v_9_saha_human RummaGEO Drug Perturbation Signatures 1.0 null BCAS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00723261 spleen_3d HPA Tissue Sample Gene Expression Profiles 1.0 1.05729 lymphnode_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.01819 outer CP in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.850323 mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84971 GTEX-T5JW-1626-SM-3GADZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.15986 BRD-K87640319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46461 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04412 BRD-A52749901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13741 H4K20me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.643091 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35923751 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11709 TCP10L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28792 BRD-K21937603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00801 BRD-K46121327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30628 hsa-miR-4497 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE60837_6_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2192 SU-DHL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25871 BRD-K47883435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25556 GSE210885_5_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K26503698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07366 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null fulvestrant-6965 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11344 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.85564 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.871357 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-1826-SM-4AT6F GTEx Tissue Sample Gene Expression Profiles 1.0 0.919007 IRF1 ENCODE Transcription Factor Targets 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.428418 BRD-K75981085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52305 endosome GO Cellular Component Annotations 2015 1.0 null TNFRSF8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00619983 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946132 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27333 CBL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00531568 RFXAP NURSA Protein-Protein Interactions 1.0 0.081964 harpagoside-6636 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCF7_Ivosidenib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014375 BRD-K06279388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55353 orbital frontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0276 Perturb_11265_KO_Bmal1_SRP260650 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BRD-K49635910 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67278 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08078 H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null PRRG4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0111799 Perturb_13049_KD_H19_SRP063608 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.47307 CCDC62 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00778342 THP1 DepMap CRISPR Gene Dependency 1.0 2.76221 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23788 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941978 Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.8098 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78751 raubasine-2898 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.865924 Lung adenocarcinoma_LUAD_TCGA-69-7980-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA Rummagene Transcription Factor Associations 2026 1.0 null GAMT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00590856 BRD-K97348029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12335 CRCGN015_MCF10A.WT.HP_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.67418 KYSE520 CCLE Cell Line Gene CNV Profiles 1.0 1.98801 GSE63048_11_v_8_morc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null AREB6 MotifMap Predicted Transcription Factor Targets 1.0 null RA-25-VV91_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202831 aceclofenac-7029 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-P4PP-0926-SM-48TBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.18719 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.70298 regulation of plasma membrane bounded cell projection assembly GO Biological Process Annotations 2023 1.0 null NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.88387 PMC3518872__F3 PFOCR Pathway Figure Associations 2024 1.0 null EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.21887 EWSR1_KD_GDS4962_466_human_Ewing sarcoma and prostate cancer GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17008 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TCFCP2L1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-A61304759_tanespimycin_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CISH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00962016 BRD-K82187446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.9141 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41037 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCIH810 CCLE Cell Line Gene CNV Profiles 1.0 2.88532 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null CRCGN017_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.70465 A549 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.996902 HCC202 CCLE Cell Line Gene Expression Profiles 1.0 2.6434 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AGMAT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00807233 nilutamide-6763 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K43271856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27271 neoplastic GeneRIF Biological Term Annotations 1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.957804 FOS_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Baricitinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143986 431_AQR_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.757891 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19301 Perturb_6645_OE_LL37_SRP282532 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.07097 GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20798 PMC3518872__F3 PFOCR Pathway Figure Associations 2023 1.0 null Koolen de Vries syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.314 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cisplatin_homo sapiens_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K56799639 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48861 CRCGN013_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11979 BRD-K55891520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00254 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-WFON-1426-SM-4LVMT GTEx Tissue Sample Gene Expression Profiles 1.0 0.911812 EGR1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16677 GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07261 TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.66495 FOXA2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BL2262 (DOCK9) NURSA Protein Complexes 1.0 null SRSF9_02_90 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60261 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59541 SLPI LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606908 PMC12678582-41698_2025_1153_MOESM5_ESM.xlsx-Sheet1-Common_genes_between_OVCA420-ZNF217_and_MCF7_157_965_1122_ZNF217 Rummagene Transcription Factor Associations 2026 1.0 null ZFP36L1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00683909 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147613_1_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K13087600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10682 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06273 ABCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37159 ESRRA ENCODE Transcription Factor Targets 1.0 null H3K4me1_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE147943_2_v_3_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BB-62-SZ35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333184 alpha-estradiol-4434 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21729 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NF1 NURSA Protein-Protein Interactions 1.0 0.081964 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15556 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 8870_THADA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.612346 NR2F1 JASPAR Predicted Transcription Factor Targets 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.027897 Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.834984 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null H3K9me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7389 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null DCLK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00482394 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3922 H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lymph_Node-memory b cell Tabula Sapiens Gene-Cell Associations 1.0 5.38555 GRANTA-519 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.75902 paraventricular nucleus, cap part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32249 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138468_3_v_6_dyrk1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE148692,GSE148695_7_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE146074_9_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.3268 HCC1833 CCLE Cell Line Gene Expression Profiles 1.0 2.12383 GSE227127_1_v_0_diclofenac_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPP6R3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0091457 GRPEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06831 GTEX-XUJ4-0226-SM-4BOP8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51834 Perturb_7075_KO_OGT_SRP252759 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.47022 PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null Cerebrovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.558 GTEX-XOTO-2826-SM-4B65I GTEx Tissue Sample Gene Expression Profiles 1.0 2.36632 CRCGN009_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2272 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K71755682 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20933 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BL1296 (IRS1) NURSA Protein Complexes 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lung HPA Tissue Protein Expression Profiles -1.0 -1.12523 BRD-K67007076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89906 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BEN CCLE Cell Line Gene Expression Profiles 1.0 2.18676 THTPA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00527038 r4 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16773 BRD-K35687265_S1362_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.918323 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.00539 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE58724_1_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XUJ4-2026-SM-4BOOW GTEx Tissue Sample Gene Expression Profiles 1.0 1.32087 NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.992268 BRD-K13696195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27827 ZC3H11A ENCODE Transcription Factor Targets 1.0 null MCF7_AC480_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0122585 BRD-K53797069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2407 HCC202 CCLE Cell Line Gene CNV Profiles 1.0 1.64209 COBLL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00647572 ATF1 ENCODE Transcription Factor Targets 1.0 null endometrium_8b HPA Tissue Sample Gene Expression Profiles -1.0 -2.53446 Perturb_5028_KO_Oct1_SRP080768 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.15615 H3K36me3_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-1526-SM-4LVMG GTEx Tissue Sample Gene Expression Profiles 1.0 0.971345 BRD-K75243062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32623 Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85110576 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31243 FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.7736 Perturb_18563_KO_Tal1_SRP117185 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.99582 BRD-A21168039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44303 SNU475 CCLE Cell Line Gene CNV Profiles -1.0 -1.34932 involucrin GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IL7R LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00866309 GM133 BioGPS Cell Line Gene Expression Profiles -1.0 -1.32707 PMC6356085__F6 PFOCR Pathway Figure Associations 2023 1.0 null IRAK4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00577667 CRCGN016_MCF10A.WT.HP_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.71978 Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0626 CHRNE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0046837 PANC0327 CCLE Cell Line Gene CNV Profiles -1.0 -1.50246 ARCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37559 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SERPINI1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00572994 H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63098 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45293 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24128 Liver Diseases CTD Gene-Disease Associations 1.0 1.24812 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null A549_PD173074_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.015066 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_AG-14361_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0314625 BRD-K65182930_NVP-AUY922_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PRR5L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00777033 TASOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21282 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RI1 CCLE Cell Line Gene Expression Profiles 1.0 1.35835 BRD-A29734477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14587 gut TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.13263 ginkgolide A-3260 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00689495 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.30007 ADM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22679 BRD-K23617623 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24441 KAT2A ENCODE Transcription Factor Targets 1.0 null RPL37A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0073193 medial subhabenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26309 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Dorsal peduncular area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45969 GSE174498,GSE174500_3_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null KASUMI1 CCLE Cell Line Gene Expression Profiles -1.0 -1.74934 Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of catalytic activity GO Biological Process Annotations 2015 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null GSE202744_1_v_3_toyocamycin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles 1.0 1.24181 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.33554 GSE230329_0_v_3_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0972 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.17265 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 2.30194 urinary bladder HPA Tissue Protein Expression Profiles 1.0 1.42494 H3K4me1_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957582 BRD-K21841771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58238 BRD-K69496360_7831785_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GEM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00549831 A2058 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.78172 GSE148252_5_v_4_npas4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE89729_0_v_1_ppard_human RummaGEO Gene Perturbation Signatures 1.0 null TRIM28 ENCODE Transcription Factor Targets 1.0 null streptozocin-5836 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ACKR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00715296 B3GNT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20364 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null OB-06-WW76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.679738 primary auditory cortex (core)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23993 GTEX-OIZI-0226-SM-2XCEE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935259 Perturb_4841_OE_Gfi1/Pou4f3_SRP220284 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Prostatic Diseases CTD Gene-Disease Associations 1.0 1.06952 GSE210770_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22093970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07383 K562_Thalidomide_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0234826 A549_Barasertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0129596 TMEM39B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01871 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMMY-0126-SM-4DXTP GTEx Tissue Sample Gene Expression Profiles 1.0 0.973597 OB olfactory fiber layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00857 TRIM28_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23434564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24081 LUDLU1_LUNG CCLE Cell Line Proteomics 1.0 2.14286 CRCGN016_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.89383 Posterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43337 SKRC20 DepMap CRISPR Gene Dependency 1.0 2.89601 biological_process GO Biological Process Annotations 2015 1.0 null ARHGAP24 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00547055 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null CASP7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00626684 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null useful GeneRIF Biological Term Annotations 1.0 null H3K36me3_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-0126-SM-4DM6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.06376 BRD-K31483891 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05186 phenindione-7289 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HS611T CCLE Cell Line Gene Expression Profiles 1.0 1.35094 endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.229888 endosome LOCATE Curated Protein Localization Annotations 1.0 null GSE104508_2_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_6340_KO_Nrtn_SRP273435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.1389 GTEX-S95S-1026-SM-4B64M GTEx Tissue Sample Gene Expression Profiles 1.0 1.24104 TAL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Perturb_17490_KO_Krt13_SRP248501 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.23496 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K48113764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29418 CRCGN017_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18642 GTEX-WYJK-0526-SM-3NM8Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.889964 H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IZUMO4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00704158 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.854996 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34236 BRD-K59030325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.9774 Perturb_7509_OE_ILF3_SRP195616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.14626 K562_ITSA-1_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177098 GSE84148,GSE96938_0_v_1_nrros_mouse RummaGEO Gene Perturbation Signatures 1.0 null BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 IL33 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00993939 TUBG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39878 NSD3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00452953 BRD-K07501194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14633 GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE197571_3_v_1_foxm1_human RummaGEO Gene Perturbation Signatures 1.0 null periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30654 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19797726-SuppTable1a GeneSigDB Published Gene Signatures 1.0 null GSE215086_0_v_1_batf_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE148066,GSE157787_3_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lateral septal nucleus, rostral (rostroventral) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03171 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ST14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.173 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050982 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13569_KD_Crebl2_SRP214575 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.585 spleen_3b HPA Tissue Sample Gene Expression Profiles 1.0 1.0377 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.13555 Perturb_17216_KO_Dcaf1_SRP194105 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.30114 PMC7388612-vdaa078_suppl_supplementary_table_6.xlsx-MRs_PN_Rim-vs-MRs_PN_C-MR_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPN-0011-R3A-SM-2I5FC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12864 MS4A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00520028 GTEX-QV31-0126-SM-447BP GTEx Tissue Sample Gene Expression Profiles 1.0 2.14424 UM-UC-3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.89015 primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.838271 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.424 GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null salsolinol-2791 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null outer SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.844478 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-150 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100666_HIP_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.57854 TAP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00716593 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null NCIH2882 DepMap CRISPR Gene Dependency 1.0 2.99147 BRD-K43981353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28702 BRD-K34414758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.49122 Longissimus lumborum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.571 Carcinoma, Ovarian Epithelial DisGeNET Gene-Disease Associations 1.0 null CE-18-AP15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.476898 PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.36791 H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null K562_Raltitrexed_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0230681 CRCGN017_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.92235 BRD-U22633929_XMD11-85H_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.36554 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971111 MCF7_Disulfiram_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136047 SIGLEC11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00696986 SDS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00693773 PIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37183 GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.03519 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19201 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875904 Intraciliary transport particle A COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.098 KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.5462 GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0008 CHD2 ENCODE Transcription Factor Targets 1.0 null SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29889 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null BRD-K36149853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70335 EP300_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLTM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61151 hsa-miR-296-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CD160 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00578081 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.03232 BRD-K21680192_mitoxantrone_SKBR3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hESC_Derived_CD56+_Ectoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.07335 EVI2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00608227 amygdaloid complex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03611 GSE213588_8_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null ACOT13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65004 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.64601 SEPHS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00752117 POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ESRRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.91053 ELK4 ENCODE Transcription Factor Targets 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56618252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23036 pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1612 GSE171572_5_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H128 COSMIC Cell Line Gene Mutation Profiles 1.0 null PHF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82727 NCI-H1944 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17769 IKZF1 ENCODE Transcription Factor Targets 1.0 null Perturb_9496_KO_Bscl2_SRP345421 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.51525 r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20148 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5WG-1126-SM-4LMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06606 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1838 CCLE Cell Line Gene Expression Profiles -1.0 -2.06485 GSE178714_6_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE171175,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZN-2226-SM-3DB88 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98776 BRD-K38904629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02203 GTEX-P4PP-0126-SM-3LK69 GTEx Tissue Sample Gene Expression Profiles 1.0 0.958472 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE171837_0_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47533 BRD-K67898193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35995 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13915 GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null BRD-K97487406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14533 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE129725_4_v_0_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901199 H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC56 CCLE Cell Line Gene Expression Profiles 1.0 1.79943 BRD-K93519076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34847 heart muscle HPA Tissue Protein Expression Profiles -1.0 -1.12523 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66902379_MLS-0435526.0001_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K73290515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42774 GTEX-PWCY-0226-SM-48TD8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.885869 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35731 PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1 Rummagene Transcription Factor Associations 2026 1.0 null EBF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00502309 paclitaxel_homo sapiens_gpl570_gse39042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K12578029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09475 GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles 1.0 1.28702 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KOSC-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.17982 M059J Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.57372 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKBR3 CCLE Cell Line Gene Expression Profiles 1.0 1.68968 CCL4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00626014 Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.02522 BRD-K51643438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81707 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.994898 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -4.15763 RBBP6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00776442 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.65271 TE-11 GDSC Cell Line Gene Expression Profiles 1.0 2.15357 Perturb_15615_Mut_Dmd_SRP329695 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.78724 mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13095 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Erythroleukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K78818514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04524 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56987307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25318 ALB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.010045 MCF7_EED226_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176606 MAP2K3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18831 Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_PD98059_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177039 BRD-K61366105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68331 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K52522949_-666_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE187006_0_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Lapatinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155321 MCF7_Belinostat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0126268 FU-OV-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.67052 HNRNPR Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Cyclocytidine HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0215506 layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23974 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TFRC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00582814 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G-401 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.64173 DAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00571417 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04221 BRD-K92176613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07794 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRCC3 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN009_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01109 MCF7_Glesatinib(MGCD265)_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0122852 orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.879789 AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null HCC4006 CCLE Cell Line Gene CNV Profiles 1.0 1.51321 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16284 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832315 H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1785 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Quercetin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014128 CRCGN016_MCF10A.TP53.M_24H:A19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80809 BRD-K56119660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87841 WAOSEL DepMap CRISPR Gene Dependency 1.0 4.25325 BRD-K74988798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06572 BRCA1 ENCODE Transcription Factor Targets 1.0 null ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.3068 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.22166 Perturb_13563_KD_Brd4_SRP235584 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.52686 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.785 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06517 pyk2 GeneRIF Biological Term Annotations 1.0 null HSPA1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00774601 Filanesib DeepCoverMOA Drug Mechanisms of Action 1.0 1.11 genistein-4459 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null S100A8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0054524 BRD-K24585433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5841 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lixivaptan DeepCoverMOA Drug Mechanisms of Action 1.0 0.49 GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25025 TXNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07911 BRD-K13526564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03511 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-1926-SM-4E3IW GTEx Tissue Sample Gene Expression Profiles 1.0 0.959526 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GATA2-19941826-K562-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0226-SM-4DM6V GTEx Tissue Sample Gene Expression Profiles 1.0 0.978687 CEP83 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00945171 COPS9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43731 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null REST ChEA Transcription Factor Targets 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ALDH3A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00693556 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38703 STAT3 ChEA Transcription Factor Targets 1.0 null Paraventricular hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08195 KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.07 r5 part of the oral Sp5 subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11571 HUH-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.1387 RGL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0065191 SIMA CCLE Cell Line Gene Expression Profiles -1.0 -1.53017 Perturb_16939_OE_Prkag1_SRP162537 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.11531 Rabaptin InterPro Predicted Protein Domain Annotations 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.68701 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymph node HPA Tissue Gene Expression Profiles 1.0 1.08678 TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 2.62391 HPS4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497857 Perturb_10833_KO_Xbp1_SRP262377 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-WZTO-0126-SM-3NM95 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26668 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COGAR359 DepMap CRISPR Gene Dependency 1.0 2.93853 BRD-K58140298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74572 LAMB3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00564125 HNF4A ENCODE Transcription Factor Targets 1.0 null NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A4BK-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DSCAM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00794159 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_203_KD_Id1/ld3_SRP193147 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.57402 19658189-TableS3 GeneSigDB Published Gene Signatures 1.0 null H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K06489778 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01202 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K06577881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36079 BRD-A39996500_radicicol_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37616496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13844 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CHD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Ruxolitinib_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0121841 CX3CL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00955674 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07225 BRD-K05639803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36112 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SLC1A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00520135 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33437 TAL1_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832123 H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE178714_6_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333285 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13782 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15012 GSE109140_0_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RN64-1626-SM-48FD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04955 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839154 BRD-K18179332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40145 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18310505-TableS1 GeneSigDB Published Gene Signatures 1.0 null CORL24 CCLE Cell Line Gene Expression Profiles -1.0 -2.3258 GSE90552_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WYJK-0126-SM-3NMAB GTEx Tissue Sample Gene Expression Profiles 1.0 1.46171 BRD-K43594798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.769 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.76185 PMC11651170-pt4c00533_si_002.pdf-70-ZNF490_ZNF490 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K09975619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02656 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977841 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84287 mantle zone of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15183 BL326 (RFX5) NURSA Protein Complexes 1.0 null BRD-K86002795 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00495 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041539 hmc1 HPA Cell Line Gene Expression Profiles 1.0 1.01235 GABPA ENCODE Transcription Factor Targets 1.0 null BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16209 propoxycaine-6161 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81623965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45958 ARID4A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00681489 HIF1AN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00778044 BRD-K81916372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73871 K562_Roscovitine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186498 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 bone marrow HPA Tissue Protein Expression Profiles -1.0 -1.12523 Obesity GWAS Catalog SNP-Phenotype Associations 1.0 0.449549 BRD-K82538319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78432 H3K9me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Rigosertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170428 16288205-GeneTable2 GeneSigDB Published Gene Signatures 1.0 null GTEX-RM2N-1426-SM-2TF4H GTEx Tissue Sample Gene Expression Profiles 1.0 0.836356 outer CP in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05056 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV2-25802403-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE166004_3_v_2_pld1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K24369860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92634 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IL18RAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00948281 ASH2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02403 GATA1 ENCODE Transcription Factor Targets 1.0 null medial part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53839 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5A ChEA Transcription Factor Targets 1.0 null ZNRD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00473516 GSE199204,GSE211619_4_v_1_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19327 MITF ChEA Transcription Factor Targets 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MO-1726-SM-33HB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00953 CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.97172 15(S)-15-methylprostaglandin E2-7521 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K51791049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59819 GSE223334_1_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIGMAR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0061235 Squamous Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null Orbital area, medial part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05254 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042556 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.90228 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997643 BRD-K45683404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14669 Hip circumference adjusted for BMI GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.10458 GSE199660_1_v_0_secretin_mouse RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.58489 hindgut TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.26185 BRD-K34095226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80648 Drug dependence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.505 SCNN1G LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00495803 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Estimated glomerular filtration rate GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.02218 intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.230931 IL10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00639739 NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_TCFCP2L1_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-NPJ8-0011-R4a-SM-2HML3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03591 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null fulvestrant-1146 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DYNLT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99567 K562_PFI-1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0181267 FU97 CCLE Cell Line Gene CNV Profiles 1.0 1.33346 Photoreceptor cell cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.074 Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21887 Multimerin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.918 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.985927 Intraciliary transport particle B COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.17 GTEX-X261-0126-SM-3NMD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04665 MCF7_Entacapone_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147405 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K91623615_ABT-751_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GRAP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00720948 ECC12 CCLE Cell Line Gene Expression Profiles -1.0 -1.64961 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056198 GSE214823,GSE214824_5_v_7_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDKN2AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.036 BCL11A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.51604 BRD-K34508425_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K79635719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19451 Intelligence DisGeNET Gene-Phenotype Associations 1.0 null SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 2.16568 GSE160083,GSE160084_2_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PSMA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00917619 GALM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10116 Prostate adenocarcinoma_PRAD_TCGA-G9-6343-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95500860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35661 K562_Danusertib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151064 GTEX-X4XX-0126-SM-3NMC2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.61231 GTEX-PWO3-0011-R5A-SM-2I5EZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.837341 GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.29852 PMC10534007-Table_2.xlsx-S4_unique_down_MSC_V-745_elements_included_exclusively_in_VM-CUB1_MSC_down_MSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRK-0126-SM-3NB1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.06344 Perturb_1680_KO_Nox4_SRP356837 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.34981 NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 harmalol-2892 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NOL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2754 GTEX-P4PQ-1626-SM-2HMKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14622 HUWE1 Pathway Commons Protein-Protein Interactions 1.0 null THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.8077 GSE169356_2_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Body Mass Index Procedure DisGeNET Gene-Phenotype Associations 1.0 null BRD-K24271020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16937 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13332_KD_Nrip2_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.72845 E2F4 ENCODE Transcription Factor Targets 1.0 null GSE171712_0_v_1_scgb1a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15876 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null RBMS3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00593799 EIF2S3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35991 Clorgiline DeepCoverMOA Drug Mechanisms of Action 1.0 0.44 Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A6GE-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HAVCR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00706461 r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22406 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23458 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25553 BRD-K04725393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24169 Polycystic Ovary Syndrome_Skeletal muscle_GSE6798 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.85025 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.966979 GSE214725_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE226584,GSE226589_3_v_0_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K77535986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52534 EP300_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K23956364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34707 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SIN3A-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CD300C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0074192 CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERFLCSQ1_LUNG CCLE Cell Line Proteomics 1.0 3.62758 PLSCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23923 enzyme regulator activity GO Molecular Function Annotations 2015 1.0 null HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.69386 Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05006 H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32679 BRD-K73275682 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20037 BRD-K89952634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03444 Metolazone DeepCoverMOA Drug Mechanisms of Action -1.0 -0.37 EOMES ChEA Transcription Factor Targets 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CYP27B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05711 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null K562_JNJ-7706621_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0199613 BCL2L1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00359939 zidovudine-3211 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K89650689 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40305 GSE129370_2_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71E-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K12531686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52639 CRCGN016_MCF10A.WT.HP_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98501 RBBP5 ENCODE Transcription Factor Targets 1.0 null GSAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0057086 BRD-K12866026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21521 TEAD4 ChEA Transcription Factor Targets 1.0 null H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-UPIC-1626-SM-4IHKT GTEx Tissue Sample Gene Expression Profiles 1.0 1.43312 BRD-K26866198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15644 GTEX-SSA3-0002-SM-3P61R GTEx Tissue Sample Gene Expression Profiles 1.0 1.02903 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles 1.0 1.45371 GSE158834_11_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CHD4 ENCODE Transcription Factor Targets 1.0 null BRD-K26306512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05245 Mosaic variegated aneuploidy syndrome 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.626 BRD-K35491869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09062 16288205-GeneTable3 GeneSigDB Published Gene Signatures 1.0 null carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE77108_8_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927323 GSE77178_1_v_3_ccnd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.63571 Microglial cell_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WY7C-2126-SM-3NB2R GTEx Tissue Sample Gene Expression Profiles 1.0 0.941086 H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.013 GTEX-WFON-1626-SM-4LVMV GTEx Tissue Sample Gene Expression Profiles 1.0 0.973071 Perturb_13567_OE_Pparg_SRP108250 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.87362 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null Cannabis use GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.9 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21412 Uterus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.25939 required GeneRIF Biological Term Annotations 1.0 null POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-8021-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKNO1 CCLE Cell Line Gene CNV Profiles -1.0 -2.17151 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0909 BRD-A03121430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48428 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.74411 PMC8872993-41380_2021_1274_MOESM5_ESM.xlsx-Table_S7-Supplementary_Table_S7_TCF7L2_Target_Genes_Identified_by_Integration_of_RNA-seq_and_ChIP-seq_Data_TCF7L2 Rummagene Transcription Factor Associations 2026 1.0 null TBRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06975 latamoxef-5609 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null CARD8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0106472 9210_TPP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.507278 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CXCL6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00668847 Anterior hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17353 moxisylyte-1682 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null terconazole-2844 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K43316594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74899 MDAMB453 CCLE Cell Line Gene CNV Profiles 1.0 1.50167 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K21119095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73659 BRD-K78297750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24326 BRD-K69048559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50082 RIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16517 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null prostate GTEx Tissue Gene Expression Profiles 1.0 1.18958 GSE113221,GSE113968_6_v_1_prdm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1349 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-1526-SM-3DB9D GTEx Tissue Sample Gene Expression Profiles 1.0 0.990048 GTEX-XXEK-2226-SM-4BRUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.01631 GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905027 BRD-A39996500_radicicol_A549_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYP11B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00655079 GSE144115_4_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP3K20 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606733 CRCGN017_MCF10A.TP53.M_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69515 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VPS45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75907 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85572169 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53391 r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39594 GSE150055_0_v_1_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K99125195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1853 RDH14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00584616 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adventurousness GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.822185 PMC8528285-pbio.3001085.s010.xlsx-Fig_8C-MLX_3T3_MLX Rummagene Transcription Factor Associations 2026 1.0 null Perturb_16317_KD_POU2F2_SRP336261 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.13471 retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.8672 PMC11665559-jciinsight-9-183889-s131.xlsx-Fig2DiffBind_MYB_TR-PLEvsNTC-WT-Nearest_Ensembl_MYB Rummagene Transcription Factor Associations 2026 1.0 null gallbladder HPA Tissue Protein Expression Profiles 1.0 1.42494 t99-vena-cava_male_1w MoTrPAC Rat Endurance Exercise Training 1.0 1.70471 ribostamycin-7123 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_PD173074_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139531 ARG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00643432 Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXD4L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00512524 Gastric Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.05598 lovastatin-6633 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959823 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null r9 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19064 Nutrition disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.202 Anterior cingulate area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77029 inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17717 YEATS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38212 BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261643 BRD-K83115645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70836 NRG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0126728 MXI1 ENCODE Transcription Factor Targets 1.0 null BRD-K64317863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.67834 BRD-K20525312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02929 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833482 ALPK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00572913 EFO-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF Rummagene Transcription Factor Associations 2026 1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_GSK-LSD1 2HCl_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184135 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99089 GSE132759_4_v_2_fgfr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CISD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00540268 Cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K43684831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22981 H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39623 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46069 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE236486_1_v_2_arnt_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_8_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54777 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.02749 Cranioectodermal dysplasia 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.66 brain GTEx Tissue Gene Expression Profiles -1.0 -0.857106 BRD-K36566880 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29463 BRD-A62182663_YK 4-279_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Immunodeficiency 52 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.841 YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SH10TC DepMap CRISPR Gene Dependency 1.0 3.51638 CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Fragile X Syndrome DisGeNET Gene-Disease Associations 1.0 null SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE129389_0_v_5_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRDX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00583376 HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18502 REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.999796 IFT172 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00682422 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Fetal Kidney Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.53279 MCF7_Roxadustat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147675