association	dataset	threshold value	standardized value
MOLM-16	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
BRD-K97445906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.74381
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.866225
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.9873
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54069
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.30352
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31935
UNC119B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85074
tanespimycin-428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.699107
HNRNPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45877
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.11431
Leber congenital amaurosis 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
FLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40881
SRY	ChEA Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.870211
NCIH647	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59906
Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33034
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931187
496100465_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.3439
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
A-VN-1203-2004(H5N1)_Day4-10^2pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.85509
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00023
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08568
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.886
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3894
BRD-K95735171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65531
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.685
Prostate adenocarcinoma_PRAD_TCGA-HC-8262-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REEP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39916
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Syndromic microphthalmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.809
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5928-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C11orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98306
ZNF225	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39023
BRD-A90462498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01144
OCILY10	CCLE Cell Line Gene Expression Profiles	1.0	1.81956
19061838-TableS14	GeneSigDB Published Gene Signatures	1.0	null
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09239
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.12242
Y-shaped link	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.177
dichlorophen	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30912
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00137
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	2.0011
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
LRFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56189
TASOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39955
BRD-K98940411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55004
Age related macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.597
LS-1034	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K79148949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54961
H3K27me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4406
BRD-K99131664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64381
NR4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57559
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22031
Retinal macular dystrophy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8844
H3K27me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71839
LAN2	DepMap CRISPR Gene Dependency	1.0	4.21068
DNASE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29043
BRD-K95323755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51338
SCAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18779
H3K27me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31644794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29604
BRD-K91516693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05745
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.656648
estradiol 17-beta-dehydrogenase activity	GO Molecular Function Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A83L-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A82843133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05645
PMC7203425__F1	PFOCR Pathway Figure Associations 2024	1.0	null
NPAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45693
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH650	DepMap CRISPR Gene Dependency	1.0	2.04046
SARS-CoV MA15_Day1-PFU-10^2_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.0444
UNCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03863
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055966
ESRRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38978
BRD-K53889798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01656
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.22454
Bladder Urothelial Carcinoma_BLCA_TCGA-R3-A69X-01A-22R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35308744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22086
FSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95183
KHM1B	CCLE Cell Line Gene CNV Profiles	1.0	1.33842
KYSE270	CCLE Cell Line Gene CNV Profiles	1.0	1.63974
CAPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68257
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6989-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27797
hsa-miR-3688-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
MPP7-DLG1-LIN7 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.402
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SJSA1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.49111
intracellular part	GO Cellular Component Annotations 2015	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
OVSAHO	CCLE Cell Line Gene CNV Profiles	1.0	1.67729
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.29344
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.78386
Fundus albipunctatus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.257
Retinal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.145761
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Retinol metabolism(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42239
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.37341
496100312_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.49951
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28417
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66165
Nuclear exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.141
RRAGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36172
BRD-K60847609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26904
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4169
HCC827	CCLE Cell Line Gene CNV Profiles	1.0	1.38613
HIPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56382
BRD-K56939159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52293
DIFI	DepMap CRISPR Gene Dependency	1.0	3.97848
Vitelliform macular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.676
MEIS2_02_30	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.7866
ALG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58974
MTCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91853
imatinib-483	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bardet-Biedl syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
LNZ308	CCLE Cell Line Gene Expression Profiles	1.0	1.38853
JHH5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80126
fluvoxamine-3995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NADP	CTD Gene-Chemical Interactions	1.0	null
BRD-K88421348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25669
ICE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48102
LN382	Achilles Cell Line Gene Essentiality Profiles	1.0	1.86594
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06061
NCOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68926
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-3.0232
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864742
propofol-3048	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A69950438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85343
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTRH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43592
MDST8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74013
differential	GeneRIF Biological Term Annotations	1.0	null
OVTOKO	DepMap CRISPR Gene Dependency	1.0	3.21028
PCYT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25427
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00718
BRD-K29083370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44733
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	5.19055
Rhabdomere	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.626
Retinal rod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.987
non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.595
HIVEP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33027
THAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89102
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47496
terpenoid metabolic process	GO Biological Process Annotations 2015	1.0	null
CMTM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67707
pipemidic acid-6752	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ABL1_knockdown_100_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.52626
UBE2S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00151
UACC-257	GDSC Cell Line Gene Expression Profiles	1.0	3.46661
CBFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01655
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6918
alcohol dehydrogenase (nadp+) activity	GO Molecular Function Annotations 2015	1.0	null
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23166347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09292
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65849
NCIH1944	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9026
9+0 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.487
PMC7767764__F1	PFOCR Pathway Figure Associations 2024	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	2.49652
SP140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46128
SARS-CoV MA15_Day4-PFU-10^2_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.809886
HEMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0104
MC116	CCLE Cell Line Gene Expression Profiles	1.0	1.65476
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.861122
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TW-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.950168
Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76628
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21216
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ARHGEF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21672
pirinixic acid-481	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83604
BRD-K68985225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45448
SSH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38294
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
KYSE-450	GDSC Cell Line Gene Expression Profiles	-1.0	-1.66929
LOVO	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.22218
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12519
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14449
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15028515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86066
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05545
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.219969
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A1HR-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIGQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84171
RH-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.44232
NRF1_02_62	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.90046
response to external stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K25161864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30321
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03841
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ADRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63127
TLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54787
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7026
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
outer	GeneRIF Biological Term Annotations	1.0	null
BRD-K46620987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03889
HS683	Achilles Cell Line Gene Essentiality Profiles	1.0	1.20107
WDR82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56877
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CB-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K15434241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05103
Bestrophinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.97116
KHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22058
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849362
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7321-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
IOMMLEE	CCLE Cell Line Gene Expression Profiles	1.0	1.67929
photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.06195
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.56455
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38616
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.20189
myopia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.991487
BRD-K66032509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27158
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28812
Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7767764__F1	PFOCR Pathway Figure Associations 2023	1.0	null
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BZW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67921
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98411
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13241788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57813
BRD-A89038047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85842
BRD-K94790210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35482
STAT6_02_57	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.23266
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059783
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	1.87295
OV90	DepMap CRISPR Gene Dependency	1.0	4.58435
GATA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18698
JAGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69426
Axonemal microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
ZNF215	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18187
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.88922
IGFBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60842
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.0151
vulnerability	GeneRIF Biological Term Annotations	1.0	null
PEO1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
oxybenzone-6469	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20365
organic cyclic compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K40011635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17876
Meckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3404
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6909-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.32132
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5554
BRD-K26399271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13449
PEER	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69184
BRD-K98343273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82504
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057297
NCIH446	DepMap CRISPR Gene Dependency	1.0	2.55361
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073617
CCDC153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52988
TMEM198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99468
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19783
ASCL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03841
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.472604
Lung squamous cell carcinoma_LUSC_TCGA-60-2724-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Interphotoreceptor matrix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.738
SNU1076	DepMap CRISPR Gene Dependency	1.0	3.50713
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5625
BRD-K66189308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20618
TP63	ChEA Transcription Factor Targets	1.0	null
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10809
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	3.14855
BRD-K57468571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04158
BRD-K88934376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52517
BRD-K04725393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18926
BRD-K21713052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44326
Macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.59
ACADVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13444
BRD-K01225799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37847
HT29	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.09065
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47856
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K39267096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2095
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NADP	HMDB Metabolites of Enzymes	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9092
NCIH2405	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34614
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.55287
HEPG2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02572
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31229
BRD-K08000110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45539
BRD-K62708569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06111
PMC2882531__F1	PFOCR Pathway Figure Associations 2024	1.0	null
retinal pigment epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441042
BRD-K22789469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01722
SEH1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6626
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.919661
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HJ-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COV644	DepMap CRISPR Gene Dependency	1.0	2.02475
ADM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18578
PLEKHO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92628
SPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61849
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8057
SPI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12206
NCIH2126	DepMap CRISPR Gene Dependency	1.0	2.38927
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1886
primary alcohol metabolic process	GO Biological Process Annotations 2015	1.0	null
Coloboma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K25176380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95344
BRD-K50432649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03883
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K36002293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09385
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.08959
BRD-K07011015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70157
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55063
Bipolar Disorder_frontal cortex_GSE5388	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.46184
LASV_FML29_8hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.51707
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36761
A498	CCLE Cell Line Gene Expression Profiles	1.0	1.38702
BRD-K64147309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24381
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
DSCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76809
mRNA_NR0B1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Vitamin A	HMDB Metabolites of Enzymes	1.0	null
abca4deficient	GeneRIF Biological Term Annotations	1.0	null
BRD-K34252131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8431
BRD-K13472433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89061
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4857
TRAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32787
hsa-miR-3689d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2381
Ciliary tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.683
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7394
TKT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54736
NCIN87	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61105
cellular lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_5915_KD_HNRNPA2B1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.22302
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	5.31699
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7965
FOXJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30651
Melanophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.177439
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.721532
BRD-K71093375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07876
BRD-K87790666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15112
SMAD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74283
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2808
abnormal eye physiology	MPO Gene-Phenotype Associations	1.0	null
BRD-K64939364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13236
Photoreceptor disc membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.8
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72833
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.38597
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27732
MTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61078
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.294748
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1173
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00137
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.4065
SW780	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38787
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.84475
Rosette	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.166
H3K27me3_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCDHB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49937
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02610196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0743
BRD-K24025166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24762
Refractive error	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.587
UXS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47327
alcohol dehydrogenase (NAD+) activity	GO Molecular Function Annotations 2025	1.0	null
SLC4A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03133
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K30117087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38579
salivary gland	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58696904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90892
PACADD119	DepMap CRISPR Gene Dependency	1.0	5.85208
BRD-K00010082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14033
Retinol	MW Enzyme Metabolite Associations	1.0	null
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914813
BRD-K50045741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66493
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
Retinal detachment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7831-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB7_01_169	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58595
Prostate adenocarcinoma_PRAD_TCGA-M7-A723-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ICC106	DepMap CRISPR Gene Dependency	1.0	2.03577
IFIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31526
phototransduction, visible light	GO Biological Process Annotations 2015	1.0	null
Sclera	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
mIMCD-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.991
MCCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08087
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ASB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42224
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.383
AF-81-IV73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383682
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.128149
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0168
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
genistein-638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSQ89	DepMap CRISPR Gene Dependency	1.0	3.0913
ES8	DepMap CRISPR Gene Dependency	1.0	3.23012
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B2-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
Outer nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.2
Schizophrenia	HuGE Navigator Gene-Phenotype Associations	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65048
KLM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83957
GSE156923_2_v_1_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.7589
MKN1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.85113
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.94368
TMEM138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18894
mRNA_SALL4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K63624341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26322
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3909
BRD-K23956044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1114
BRD-K41141507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18851
DCLRE1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81953
CKAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06772
neurological system process	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALDH3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87913
the visual cycle I (vertebrates)	HumanCyc Pathways	1.0	null
VAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08002
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53133
PWWP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62611
HNRNPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16852
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
post-lysosomal vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.578
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21128
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
XPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09316
AU565	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68845
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871927
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7611
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9466
NAD(P)-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52015
RAB22A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07979
RBE	DepMap CRISPR Gene Dependency	1.0	2.69754
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17736
NRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03155
SREK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66371
night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.565666
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF626	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07412
BRD-K55939029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74267
HMCB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73467
YWHAQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1702
BRD-K95852319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40776
phototransduction	GO Biological Process Annotations 2015	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
retinal cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.255567
reduction	GeneRIF Biological Term Annotations	1.0	null
BRD-K04771555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52665
alfuzosin-5242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.24037
BRD-K92378241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03905
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.92549
BRD-K04667232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06606
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.0361
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0707
WDCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45193
risedronate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49086
RALB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53796
L428	DepMap CRISPR Gene Dependency	1.0	3.28924
ETFBKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87905
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30885
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.726
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21987
Visual phototransduction	Reactome Pathways 2014	1.0	null
BRD-K40116023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28393
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22971
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A253	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49329
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DUSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78949
chinese	GeneRIF Biological Term Annotations	1.0	null
ZNF354B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55048
BRD-K05509844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2289
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87889654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61094
Retinitis pigmentosa 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
BRD-K04336022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23865
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.93222
Prostate adenocarcinoma_PRAD_TCGA-CH-5790-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72833997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47131
WM2664	CCLE Cell Line Gene Expression Profiles	1.0	1.80536
myopia	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bardet-Biedl syndrome 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
Sympathetic ophthalmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055748
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
myopia	GAD Gene-Disease Associations	1.0	null
mice	GeneRIF Biological Term Annotations	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00023
BRD-K65054381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36738
BRD-K61704278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27506
496100666_HIP_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	8.81949
BRD-K94913508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33445
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.34462
delayed dark adaptation	MGI Mouse Phenotype Associations 2023	1.0	null
CHORDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.808
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994187
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.148264
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.421
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
BRD-K14211116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12318
BRD-K44287054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52861
VPS33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03458
EXOSC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40101
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33128056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1476
UBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66564
Bipolar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.445
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.24472
BRD-K40733000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12234
MAP6D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72398
Ciliary vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
CRCGN014_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01318
LIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29009
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.69775
Glucose/ribitol dehydrogenase	InterPro Predicted Protein Domain Annotations	1.0	null
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12819
CJM	DepMap CRISPR Gene Dependency	1.0	2.48683
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZSCAN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2354
SGSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57488
Photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.768
GAK	GDSC Cell Line Gene Expression Profiles	1.0	2.09556
enzyme	GeneRIF Biological Term Annotations	1.0	null
dorsolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22141
RBM15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19351
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122687
a11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
ATP2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50634
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056227
Photoreceptor cell cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.653
Hepatopancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
exisulind-314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05398
tolazoline-4262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.7444
ARF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83908
HCE4	DepMap CRISPR Gene Dependency	1.0	2.27628
BRD-K00263786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0263
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K92460921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28315
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9163
CHP-134	GDSC Cell Line Gene Expression Profiles	1.0	1.83373
KDM3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52728
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4662
BRD-K95895516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0371
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1815
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05695
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9191
KCNJ11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24272
SUN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48509
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.6667
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59776
BRD-K04969760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60323
BRD-K81884775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82312
refractive error	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.88475
hormone metabolic process	GO Biological Process Annotations 2015	1.0	null
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05825
rhein	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.88541
Stargardt'S Disease	DisGeNET Gene-Phenotype Associations	1.0	null
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7666
RPMI 8226	BioGPS Cell Line Gene Expression Profiles	1.0	0.984231
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
retinoid	GeneRIF Biological Term Annotations	1.0	null
BRD-K18657361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05175
BRD-K27458941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29218
Lung adenocarcinoma_LUAD_TCGA-49-6761-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.98664
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00567
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7504
CAKI2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6296
BRD-K57667228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10638
BRD-K47947160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77334
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0432
capsaicin-3034	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K97362312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31788
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.03794
metyrapone-4606	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.276304
TAPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29185
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
rosette	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.337072
BRD-K00401259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28159
amygdaloid complex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26565
BRD-K08835142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21907
BRD-K78323315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00245
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70568
retinal	GeneRIF Biological Term Annotations	1.0	null
BRD-K34456337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2397
HS819T	CCLE Cell Line Gene Expression Profiles	1.0	1.89001
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00469
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intraciliary transport particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.834
TDGF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65078
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
OVISE	CCLE Cell Line Gene CNV Profiles	1.0	1.33325
Short-chain dehydrogenase/reductase, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K12986105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37902
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00137
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.53814
ZSCAN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60759
SOX11	ChEA Transcription Factor Targets	1.0	null
epidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.861796
BRD-K90092568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31525
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49324
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.25
illumination	GeneRIF Biological Term Annotations	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
CHEK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88769
HS863T	CCLE Cell Line Gene Expression Profiles	1.0	2.50574
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36372
RMUGS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50303
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059872
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.68591
BRD-K29264158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03099
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A59009217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39176
KE97	CCLE Cell Line Gene Expression Profiles	1.0	1.85716
BRD-K93310782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0016
Solar retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1842
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8118
CAOV3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04468
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
MICALL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2718
BRD-K28983467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10073
MAN2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89868
ISYNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53232
levomepromazine-4723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MRPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77974
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2542
Leber congenital amaurosis 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K76985713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57203
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.182723
Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NN-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.838591
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4222
chrysophanic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51939
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.04
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLPSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61877
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.34993
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4689
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23471
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lung squamous cell carcinoma_LUSC_TCGA-98-8020-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
steroid metabolic process	GO Biological Process Annotations 2023	1.0	null
cone-rod dystrophy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
response to radiation	GO Biological Process Annotations 2015	1.0	null
GSE131649_4_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6863
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7J9-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6673-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.52708
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23159
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00023
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.637999
BRD-K91241684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12243
The canonical retinoid cycle in rods (twilight vision)	Reactome Pathways 2014	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.00041
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
KIAA0232	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.90482
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TMEM14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77881
Chylomicron	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.204
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116279
not applicable_Hypothermia_GSE54229_131_mouse_Embryonic fibroblas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K43240808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26168
BRD-K83108629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19425
GAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31537
BRD-K09977699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17079
populationbased	GeneRIF Biological Term Annotations	1.0	null
visual perception	GO Biological Process Annotations 2015	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2581
FOXP1	ChEA Transcription Factor Targets	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K93945680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59723
H2BC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51152
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6E9-06A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930352
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8161
PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Liver_GSE13440_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6871
BRD-K69387464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3561
hsa-miR-766	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
raloxifene-388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ANAPC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07755
OCIM1	CCLE Cell Line Gene CNV Profiles	1.0	1.49298
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55473
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96137
JHU022	DepMap CRISPR Gene Dependency	1.0	3.51524
PALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92898
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19473
KYM1	DepMap CRISPR Gene Dependency	1.0	2.07194
posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32211
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZBTB18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07276
cycle	GeneRIF Biological Term Annotations	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.837275
CHOP-C/EBP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.528
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.829304
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ASPC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54019
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1371
HCC1187	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33205
octopamine-6491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59253
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45104
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TSEN34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32855
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.2192
BRD-A35323217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0027
BRD-K03312699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55553
PMC3910540-725780.f1.xlsx-Table_S5-MYC_target_genes_in_human_ES_cells_Ji_Wu_et_al_2011_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
LRRC45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71063
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33384
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.883102
CCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52076
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42L-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4417-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NADP+	MW Enzyme Metabolite Associations	1.0	null
MBD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10047
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3116
Meckel syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2243
BRD-K89668690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36832
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.51899
PMC7064337-elife-51373-supp1.xlsx-SUZ12_targets_shPHF19-List_of_567_genes_marked_by_SUZ12_ChIPseq_iafter_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
UBR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15938
BRD-K19418944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6439
isoprenoid metabolic process	GO Biological Process Annotations 2015	1.0	null
ENOPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72579
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DGCR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51886
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94976
BRD-K50859531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09497
BRD-K69274755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19153
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45582
signal transduction	GO Biological Process Annotations 2015	1.0	null
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36894
A427	DepMap CRISPR Gene Dependency	1.0	2.09024
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.25
BRD-A80723361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34213
BRD-K66463856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17442
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
MTMR14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75913
RAPGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68867
FAM120AOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80984
BRD-K91361836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05353
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69825
BRD-K24929039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55819
Horizontal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.063
PMC9437808-mmc5.xlsx-Upstream_regulators-IPA_Upstream_regulator_analysis_genes_that_were_downregulated_in_the_cf-mRNA_of_AZD_treated_group_at_2-hour_post_LPS_time_point_were_used_as_inputs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.73626
MROH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79293
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1445
Bacterial Infection_Leukocyte - Monocyte - Macrophage (MMHCC)_GSE6435	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.820192
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
SLC2A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3858
BRD-K33221810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02632
NCIH292	DepMap CRISPR Gene Dependency	1.0	3.45115
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19473
Usher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
Ciliary transition zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.278
REST	ChEA Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DL-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8877
response to abiotic stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K62942008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0439
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67604
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12819
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.369
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12665145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94241
HUCCT1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VPS13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53843
STX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20375
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68087668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41332
rod	GeneRIF Biological Term Annotations	1.0	null
Neural retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.011
ZNF33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01079
Cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.28
SLC25A51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92592
H3K27me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.2807
UACC62	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6429
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0763
DUS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52379
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.08881
BRD-K13679727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05733
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
LUC7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01096
CTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44154
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849362
PKDCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03562
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930352
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27926
BRD-K08679933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19553
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.106525
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
leber congenital amaurosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.828639
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06281
BRD-K06355852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15889
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC10972542-NIHMS1953997-supplement-Supplementary_Material.pdf-6-RARG_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
ROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47017
RHOQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70372
C1orf109	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20626
MINPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15663
PMC9950457-mmc3.xlsx-GRHL2_overexpression_DOWN-gene_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
ZDHHC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42194
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42637
Prostate adenocarcinoma_PRAD_TCGA-HC-7736-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-28-TM43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282983
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055814
GSE169205_3_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-CI-6621-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XPNPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81745
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.05325
Perturb_5933_KD_MRTO4_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.14963
SLC4A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05895
PPARG	ChEA Transcription Factor Targets	1.0	null
PMC2882531__F1	PFOCR Pathway Figure Associations 2023	1.0	null
NCI 460	BioGPS Cell Line Gene Expression Profiles	1.0	0.908396
SESN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93288
Lung adenocarcinoma_LUAD_TCGA-55-8299-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinitis pigmentosa 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.613
BRD-K30264389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14207
BRD-K00883748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43187
SU8686	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25329
Choroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.029
UQCRQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78244
BRD-K81706364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17689
REC1	CCLE Cell Line Gene CNV Profiles	1.0	1.39637
hormone biosynthetic process	GO Biological Process Annotations 2015	1.0	null
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.956196
OE21	DepMap CRISPR Gene Dependency	1.0	2.12278
Interphotoreceptor matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.515
LRCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26642
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2647
Prostate adenocarcinoma_PRAD_TCGA-KK-A8I4-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93831
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.62806
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03937692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17163
Myopia	DisGeNET Gene-Disease Associations	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8425-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43295075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05633
Retina lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
Vitreous chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.016
BRD-K06091213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18783
KCNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00526
MLLT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09952
loracarbef-5073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UGT3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4249
OVSAHO	CCLE Cell Line Gene Expression Profiles	1.0	1.43776
FOXO1	ChEA Transcription Factor Targets	1.0	null
PGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54374
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.9078
vision/eye phenotype	MPO Gene-Phenotype Associations	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12819
Inner plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.486
PMC10290283-biol-2022-0622-sm3.pdf-481-SRY_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
USH2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.848
B4GALT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60826
Kidney Chromophobe_KICH_TCGA-KN-8436-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05471809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08731
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56435
Kidney Chromophobe_KICH_TCGA-KN-8424-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52854560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1485
PRKCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78487
MAP3K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00439
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.6707
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4683
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K92644013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15065
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-VB-A8QN-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypothalamus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.65393
chr19_10022061_AAG_A_b38	GTEx eQTL 2025	1.0	3.14766
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50772
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.4452
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.983922
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.92726
essential	GeneRIF Biological Term Annotations	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85813125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13776
TCEA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37284
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5403
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
HDHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64611
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2315
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1934
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68371
LGALS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90024
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.683
Ciliary rootlet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
PPP1R11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64414
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.36939
all-trans-retinol dehydrogenase (NAD+) activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K66559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64545
retinitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.499614
Cone photoreceptor disc membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.72
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18101782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20714
pravastatin-lactone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14445
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YJ-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinal	MW Enzyme Metabolite Associations	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.806
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
detection of stimulus	GO Biological Process Annotations 2015	1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9571
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875492
BRD-K24453679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31666
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A9DB-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	3.9189
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7648
BRD-K48615268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97118
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
CYP2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15219
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.738104
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.861147
Choroid disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
PMC7935918-41598_2021_84338_MOESM1_ESM.xlsx-ST12-Unnamed_0_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13411423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95387
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.05074
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
age related macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.10258
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41035
SMIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15981
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11027431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54586
BRD-K68303333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45714
Retinal drusen	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
MHHNB11	DepMap CRISPR Gene Dependency	1.0	2.30737
BRD-K64730761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56026
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
UMRC6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80019
EPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96055
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0273
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5557-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74758
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03725
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.005
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.085
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21319
retinol metabolic process	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4728-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87927290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47848
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7583
KCNC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67102
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.667
HEL9217	CCLE Cell Line Gene CNV Profiles	1.0	2.10767
CRCGN011_HEPG2_24H:E23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16175
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0656
ZNF571	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35478
ASNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11926
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862123
organic hydroxy compound metabolic process	GO Biological Process Annotations 2015	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8498
A549	DepMap CRISPR Gene Dependency	1.0	2.55981
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.718012
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052095
rofecoxib-251	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77023196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.0385
EXD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08678
cones	GeneRIF Biological Term Annotations	1.0	null
PMC7910522__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8414
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-3.06414
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7936
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ACSBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79752
BRD-K97263385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00556
NFKBIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50366
BRD-K72135530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90962
ARL6IP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37262
Microphthalmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35539
Perturb_12645_KD_SIRT5_SRP311327	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ATM_KD_GSE54268_662_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Venous blood cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.32815
Prostate adenocarcinoma_PRAD_TCGA-G9-6336-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92379545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43173
single-organism process	GO Biological Process Annotations 2015	1.0	null
Ribbon synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.142
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7133
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
aldo-keto reductase (nadp) activity	GO Molecular Function Annotations 2015	1.0	null
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
FGF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23691
BRD-K12384030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24472
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4169
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930352
CTTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33109
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840373
Degeneration of macula and posterior pole	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.584
H413	DepMap CRISPR Gene Dependency	1.0	2.32815
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71845
KNS-62	GDSC Cell Line Gene Expression Profiles	-1.0	-1.66539
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2696
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.990975
20436685-ST4-2	GeneSigDB Published Gene Signatures	1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42051
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053995
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061462
clomifene-6648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MEIOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14226
Pigment granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.531
FUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90987
BRD-K41192068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34473
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11054
Sulfate adenylyltransferase complex (ATP)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.066
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TSPAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18793
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84448
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.24775
MSS51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72621
MAC2A	DepMap CRISPR Gene Dependency	1.0	3.43417
BRD-K09078201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.25696
KLF4	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3Y-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3106
NU-1025-313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
aclarubicin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.17056
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23476
GGT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20646
BRD-K26852477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26754
mRNA_SMAD7_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RAB11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40808
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6119
UACC257	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
GSE174701_5_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Choroideremia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12751
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rods	GeneRIF Biological Term Annotations	1.0	null
HM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86811
BRD-K39206254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03602
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05686
OV7	Achilles Cell Line Gene Essentiality Profiles	1.0	1.0254
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54341
furazolidone-4098	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A204	GDSC Cell Line Gene Expression Profiles	1.0	1.47194
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05608
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052514
BRD-K01367715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12769
Ripoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7579
BRD-K26376097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.24709
LOU-NH91	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12881
WDR62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74021
BRD-K58534227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21172
BRD-K49584388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19097
BRD-K67817697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52194
SF1	MotifMap Predicted Transcription Factor Targets	1.0	null
PI4K2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70991
retinol biosynthesis	HumanCyc Pathways	1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PPME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61229
CORL51	CCLE Cell Line Gene Expression Profiles	-1.0	-2.1727
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173873_1_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF431	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41224
BRD-K50247051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28575
CLDN19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29956
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4178
SEC14L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69977
BRD-K39237487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07003
PMC5132409__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K23404017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14747
BRD-K69817695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29341
BRD-K32906083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36827
ALX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97056
cell part	GO Cellular Component Annotations 2015	1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4091
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P63-26484246-CHIP-SEQ-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4005
Hereditary spherocytosis type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
estriol-6140	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51972131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09351
Inner nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.872
hsa-miR-1273g	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59061
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374243
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Zonula adherens	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.72
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11301
NCIH1930	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71779
Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.2112
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9739
TBC1D23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12959
RPS6KA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.254
vision	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K93197397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05499
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.883102
SKMEL19	DepMap CRISPR Gene Dependency	1.0	8.37262
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.276304
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Age related macular degeneration 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
ZNF583	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74211
hsa-miR-3673	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.42437
ZSCAN5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66361
BRD-K36544054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42322
Sengers syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
ZMYND19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99101
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ANKRD49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84696
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32098
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.860375
PMC5132409__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K56987307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14602
retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.41052
GSE131377_4_v_2_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF300	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90116
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871927
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056745
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.940993
BRD-A95207036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51904
ADPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68432
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Vitamin A	DrugBank Drug Targets	1.0	null
system process	GO Biological Process Annotations 2015	1.0	null
estrogen biosynthetic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4657	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
HOXD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95467
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.90976
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78639
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K21450593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16247
lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SW1573	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55035
RANBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07114
BRD-K63864310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73439
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7303
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.0
BRD-K99690279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1396
DFCI024	CCLE Cell Line Gene Expression Profiles	1.0	2.08123
TUHR10TKB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35905
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_01_354	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58538
Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Age Related Macular Degeneration	DisGeNET Gene-Disease Associations	1.0	null
GPRC5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82693
phensuximide-5097	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sickle Cell Anemia_Endothelial cell_GSE9877	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.427711
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930352
Diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LN235	Achilles Cell Line Gene Essentiality Profiles	1.0	1.71975
MMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96343
TDRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86232
Prostate adenocarcinoma_PRAD_TCGA-EJ-5531-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.04828
AP1M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18684
GSE96991,GSE97117_5_v_2_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A64774838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41834
Lung squamous cell carcinoma_LUSC_TCGA-60-2708-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78088874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24809
TE9	Achilles Cell Line Gene Essentiality Profiles	1.0	1.234
BRD-K77108448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48736
TENM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30462
FU97	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45609
detection of light stimulus	GO Biological Process Annotations 2015	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE220	DepMap CRISPR Gene Dependency	1.0	2.46469
PRPF40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1541
BRD-K14166090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33899
ALPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75942
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12155
BRD-K59263278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.546
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
BRD-K03935681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80018
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00567
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.53133
SIX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48475
BRD-K89652482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25689
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6274
ENGASE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46454
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z6-06A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5752
KIAA2013	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22077
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95495
CFPAC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48897
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2227
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC49A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20887
LS-411N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53251
BRD-A24369193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12295
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QX-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25465939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52407
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05381
hsa-miR-3646	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ZNF716	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.12536
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00567
BRD-K01709173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51615
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
MYC	ChEA Transcription Factor Targets	1.0	null
Retinal pigment epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.672
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.866225
Prostate adenocarcinoma_PRAD_TCGA-G9-6498-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI8226	DepMap CRISPR Gene Dependency	1.0	2.377
BRD-K27265817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61332
ZBTB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33342
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.723
BRD-K74129999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02723
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B7-01A-31R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3YS-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93552
detection of external stimulus	GO Biological Process Annotations 2015	1.0	null
DOT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55636
MAP2K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69408
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74256
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.96523
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876429
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83364
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77Q-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27331198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97603
IER5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73072
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.5292
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6887
BRD-K79329532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02539
LIVF001-019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.65641
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56497
TF1	CCLE Cell Line Gene CNV Profiles	1.0	1.82888
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.9796
NPIPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79335
primary cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.788275
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03841
rdh8deficient	GeneRIF Biological Term Annotations	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.882309
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9868
BRD-K05704547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05172
BRD-K18136154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95336
cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.619255
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.951946
PANC-03-27	GDSC Cell Line Gene Expression Profiles	-1.0	-1.90514
PGR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65799
BRD-K80739863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26243
nadp-retinol dehydrogenase activity	GO Molecular Function Annotations 2015	1.0	null
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
steroid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
estrogen metabolic process	GO Biological Process Annotations 2015	1.0	null
steroid metabolic process	GO Biological Process Annotations 2015	1.0	null
LP1	DepMap CRISPR Gene Dependency	1.0	2.63317
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21216
Disease	Reactome Pathways 2014	1.0	null
GGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13938
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.60353
detection of abiotic stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K04366109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21506
FAM162A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3132
macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.29615
BRD-K49698948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15192
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49256
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80227
estrone-4993	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48746
BRD-K30372674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19354
Ciliary base	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.23733
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO205	DepMap CRISPR Gene Dependency	1.0	4.57267
BRD-K70992537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56496
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7601
Lung adenocarcinoma_LUAD_TCGA-50-8459-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.98148
BRD-K05753543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08992
RS5	CCLE Cell Line Gene Expression Profiles	1.0	1.45811
ARFRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13016
Fundus dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.289
SUGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46343
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25709
Ocular albinism 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinal cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.056
3-CPMT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60196
BRD-K33260002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0941
BRD-K68731395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32451
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54894
BRD-K22778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.138
photoreceptor inner segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.08933
Photoreceptor inner segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.349
YY1	ENCODE Transcription Factor Targets	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.473
X-linked atrophic macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55287
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23393
tiaprofenic acid-4091	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
SARS-CoV MA15_Day1-PFU-10^5_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.67171
paracetamol-3025	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MYPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69663
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.806
Outer plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.622
BRD-K03602135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.464
VSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25278
ISHIKAWAHERAKLIO02ER	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57408
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO Molecular Function Annotations 2023	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
BRD-K16229712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35902
Short-chain dehydrogenase/reductase SDR	InterPro Predicted Protein Domain Annotations	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
MRPL46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56171
LRF	MotifMap Predicted Transcription Factor Targets	1.0	null
Periciliary membrane compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
monorden-449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.4517
family	GeneRIF Biological Term Annotations	1.0	null
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5174
RASSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15223
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35539
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K52231520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35587
Nematocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
BRD-K64404450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06675
BRD-K56024445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92957
BRD-K46603043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37344
Lung adenocarcinoma_LUAD_TCGA-50-5930-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24307
ZFYVE27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62777
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46308
Cone photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.975
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.16679
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.452584
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.943514
NPHP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.894
Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_WHSC2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K34228325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22237
BRD-K52872067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13679
Synaptic ribbon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.095
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63943
HCC827	DepMap CRISPR Gene Dependency	1.0	3.03695
SLC25A22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72227
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.073146
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.276
SAMD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59913
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.88513
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.831775
A549	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.16057
Sarcoma_SARC_TCGA-HB-A2OT-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPRASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91158
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A2058	CCLE Cell Line Gene CNV Profiles	-1.0	-2.28907
adipose tissue	GTEx Tissue Gene Expression Profiles	1.0	0.896068
Perturb_15804_KO_Atf3_SRP350242	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ITM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31665
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3152
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.398
BRD-K32491833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30409
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-1236	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25711
BRD-K59683187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0322
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.971887
661W cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.21825
Menarche (age at onset)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2699
KMRC20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42249
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RDES	DepMap CRISPR Gene Dependency	1.0	2.45435
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11554
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2333
YKG1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.94266
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
buspirone-6743	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04989
hsa-miR-1915	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
NCIH1836	CCLE Cell Line Gene CNV Profiles	1.0	1.54131
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6488-01A-12R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intensities	GeneRIF Biological Term Annotations	1.0	null
NCIH1355	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92184
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FP-01A-21R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8063
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K92981306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45589
BRD-A90969585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.82334
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27797
Prostate adenocarcinoma_PRAD_TCGA-VP-A878-01A-31R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5149-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0178
FUNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83719
CRCGN013_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16726
NB4	CCLE Cell Line Gene CNV Profiles	1.0	2.16766
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78109
RAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2346
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.534522
GPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62564
Cone dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.064
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32961
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.833869
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50J-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6858
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2446
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35029
N4BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60056
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55194
optic cup	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19667
Severe Myopia	DisGeNET Gene-Disease Associations	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33049
DB	CCLE Cell Line Gene CNV Profiles	1.0	1.54018
dexamethasone-255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59492
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.8336
BICD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96779
hsa-miR-638	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K05616059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34143
DCAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72686
glycine-gated chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.705
BRD-K90316899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36487
organic cyclic compound biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Retinal pigment epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.386
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-N1-A6IA-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SC-58125-254	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXM1_02_37	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.51096
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07417
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05221385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64221
SSX2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97577
Amacrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.1
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8578
ZNF692	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96087
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64612
alcohol metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03905
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29971
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55194
BRD-K09373762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.98661
ARPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60528
Lung squamous cell carcinoma_LUSC_TCGA-58-8386-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1388
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6271
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54894
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A1JX-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NLGN4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90528
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9374
NRXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56113
BRD-K72083510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0244
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059872
BRD-K72717797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08347
Optic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.497
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1155
Visual phototransduction	Reactome Pathways 2024	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05292
PNRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09139
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57312
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.31975
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15641
BCL9L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66214
MAP2K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18392
RAB6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93003
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A55025683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.09482
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.253291
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Basal labyrinth	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25955619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0715
mRNA_STAT3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
sensory perception of light stimulus	GO Biological Process Annotations 2015	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
BUB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15915
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81516
BLMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68621
delayed dark adaptation	MPO Gene-Phenotype Associations	1.0	null
BRD-K98749544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01223
Mesothelioma_MESO_TCGA-MQ-A4LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59913416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76135
BRD-K74896637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95254
IER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59951
embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.21573
Kidney Chromophobe_KICH_TCGA-KO-8403-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Optic cup	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.923
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4444
degeneration	GeneRIF Biological Term Annotations	1.0	null
ERR2 (ESRRB)	MotifMap Predicted Transcription Factor Targets	1.0	null
Bardet-Biedl syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
BRD-K05444553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54226
TMEM140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27842
17beta-dehydrogenase	InterPro Predicted Protein Domain Annotations	1.0	null
IGROV1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.60291
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01589
BRD-K79355381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75172
BRD-A75607876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98679
SLVL	DepMap CRISPR Gene Dependency	1.0	4.54835
BRD-K71452126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68129
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3479
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14748
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00137
LHX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45208
olfactorybulb	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00424
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0384
Adrenocortical carcinoma_ACC_TCGA-OR-A5LE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19712167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01712
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27797
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.8683
globe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.24428
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
ADGRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47199
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6011
Scotoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
Hereditary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.747
Perturb_12629_KD_CYGB_SRP388176	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.05281
SIN3B	ChEA Transcription Factor Targets	1.0	null
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2559
most	GeneRIF Biological Term Annotations	1.0	null
SIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79896
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.897461
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83076
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05358
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10452
PMC5417597-pone.0176679.s008.xlsx-MLL-TINT_vs_control-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
TE-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K19862308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48896
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33189
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00567
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.930666
Mueller cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.774
HMGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14204
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1914
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
DOK	DepMap CRISPR Gene Dependency	1.0	2.39114
Pterygium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
AAAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9856
PMC11589140-41416_2024_2881_MOESM1_ESM.pdf-422-RAG1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.984493
Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Scolopidium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39417
BRD-K13849122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08904
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.614
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31989
NR2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32181
NAD-retinol dehydrogenase activity	GO Molecular Function Annotations 2023	1.0	null
ALAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41751
HEYA8	Achilles Cell Line Gene Essentiality Profiles	1.0	1.42361
CCNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7535
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.7832
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.6493
BRD-K94962942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22469
biological regulation	GO Biological Process Annotations 2015	1.0	null
HCC70	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.25292
Signal Transduction	Reactome Pathways 2014	1.0	null
retina	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K12612468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07302
BRD-K67715154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73638
steroid metabolic process	GO Biological Process Annotations 2025	1.0	null
0175029-0000-3691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4033
PMC8881251-18_2022_4183_MOESM3_ESM.xlsx-ERM_vs_P4-DEGs_ERM_versus_P4_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Autoimmune optic neuritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37415
BRD-K41350512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10235
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
diterpenoid metabolic process	GO Biological Process Annotations 2015	1.0	null
TF1	DepMap CRISPR Gene Dependency	1.0	6.09829
KLF5-20875108-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cnidoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.813
retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.568775
nonmotile primary cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.975166
hsa-miR-654-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.89551
Sensillum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.347
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71875
BRD-K42671829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30945
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.215063
CRCGN014_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55292
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BF-01B-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15885
BRD-K82409466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73996
USF2	ENCODE Transcription Factor Targets	1.0	null
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	3.95416
Smooth endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.869
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4162
LGMN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50079
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
sensory perception	GO Biological Process Annotations 2015	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.55812
mRNA_CTNNB1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.915986
minoxidil-4216	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOLT-16	GDSC Cell Line Gene Expression Profiles	1.0	1.79217
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06817
PPM1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7115
Retinal	HMDB Metabolites of Enzymes	1.0	null
HOXC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97333
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10991
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IA-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C6orf89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44367
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837349
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.707536
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32762
hsa-miR-3148	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
HUCCT1	DepMap CRISPR Gene Dependency	1.0	2.33565
BRD-K31393518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11298
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.105967
Ganglion cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.561
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00023
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.58092
CACHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8053
USF1	ENCODE Transcription Factor Targets	1.0	null
nerve	GTEx Tissue Gene Expression Profiles	1.0	1.20292
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Stargardt disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.989
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12718
Bardet-Biedl syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
BRD-K14732815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36894
non-myelinating Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
CD4+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16209
Bladder Urothelial Carcinoma_BLCA_TCGA-SY-A9G5-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35035851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68936
retinol metabolic process	GO Biological Process Annotations 2025	1.0	null
retinoid metabolic process	GO Biological Process Annotations 2025	1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87093
496100468_PCx_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	9.37434
Myosin VII complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.991
catalyzes	GeneRIF Biological Term Annotations	1.0	null
oxidoreductase activity, acting on ch-oh group of donors	GO Molecular Function Annotations 2015	1.0	null
PMC7825356-8844261.f3.docx-182-ZNF562_ZNF562	Rummagene Transcription Factor Associations 2026	1.0	null
NFU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46613
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10678
Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HAPSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53655
Eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.494
Photoreceptor outer segment membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
BRD-K59078001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82219
NCI-H23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TLE2_02_53	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.01792
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3304
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K34005205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25986
NCIH2291	DepMap CRISPR Gene Dependency	1.0	2.14908
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ANKIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07576
BRD-K75730049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54053
Posterior chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
BRD-K70969650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72545
MYC-18940864-HL60-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53352
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.201
GATA2	ChEA Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T8-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUMBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33373
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
COQ8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51311
DNAJC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02242
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46105
HCC2814	CCLE Cell Line Gene Expression Profiles	1.0	1.55432
STK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46622
BRD-K73689413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26906
BRD-K74688087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22828
2-iodomelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69547
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054188
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.96754
photoreceptor	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.78235
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08921
HSBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85116
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14541
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21927299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70906
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.00041
BRD-K03713632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1538
POGLUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26761
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7333
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinal pigment epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.529
BRD-K67591072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16675
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RDH14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31262
KLHL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54109
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37872
Macula lutea	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.037
Basal part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
BRD-K28108927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64644
BRD-K12513721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04126
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
SNU1076	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96278
canadine-4020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE167886_3_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11554
neuro2a	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.28431
NCI-H1944	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13335
Pancreatic adenocarcinoma_PAAD_TCGA-YH-A8SY-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38218737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0747
BRD-A61767497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78377
higher	GeneRIF Biological Term Annotations	1.0	null
HCC1395	GDSC Cell Line Gene Expression Profiles	-1.0	-1.84137
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.850741
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04627
REST-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
oa1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3678	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.25582
BRD-K17904341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73178
Acute Myeloid Leukemia_LAML_TCGA-AB-2934-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.107104
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Photoreceptor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.747
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29E-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48169
NCIH716	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09973
SLC12A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32761
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3486
FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BD-38-QC39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281503
PMAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90098
Intraciliary transport particle A	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.912
SW48	DepMap CRISPR Gene Dependency	1.0	2.93366
496100421_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03852
CLIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96647
BRD-K38935430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36087
KLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32364
PK59	CCLE Cell Line Gene CNV Profiles	1.0	1.71424
cellular hormone metabolic process	GO Biological Process Annotations 2015	1.0	null
Syndromic microphthalmia 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.239
mRNA_ETV3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TTYH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8048
BRD-K41324679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02133
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.1378
MAP3K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05967
CRCGN013_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03555
PMC8424139__F5	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K33865795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33981
ATP13A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12512
BRD-K35386584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28651
BRD-K12833024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01936
BRD-K58237252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15477
steroid dehydrogenase activity	GO Molecular Function Annotations 2015	1.0	null
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.945688
BV-173	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CORL95	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51215
BRD-K96778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92648
BRD-K46820725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05294
PK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34363
Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18142082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65105
BRD-K30615964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20373
SKMEL2	CCLE Cell Line Gene Expression Profiles	1.0	1.95209
WM115	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92722
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QA-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DCAF12L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12837
CLASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81809
HS698T	CCLE Cell Line Gene Expression Profiles	1.0	1.5555
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05207
affected	GeneRIF Biological Term Annotations	1.0	null
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2898
IM-9	GDSC Cell Line Gene Expression Profiles	1.0	1.56435
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CPEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78045
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.29639
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11587
Prestwick-860-3040	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26435104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08151
PARP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41533
UCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10632
OC-314	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6992
MALME 3M	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
RAPGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95265
NODAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71059
AMOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68714
OAZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98409
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.177439
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
NMRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62739
Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.09065
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05302
BRD-K69901388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10882
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11427
SLR25	Achilles Cell Line Gene Essentiality Profiles	1.0	1.46158
HGC27	CCLE Cell Line Gene CNV Profiles	1.0	1.74023
Pancreatic adenocarcinoma_PAAD_TCGA-US-A774-01A-21R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
PMC5417597-pone.0176679.s006.xlsx-Tumor_MLL_vs_Control-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
fundus albipunctatus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.02271
BRD-K74568359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62634
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16974
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00023
BRD-K60107240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37449
response to light stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K40432489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75005
Congenital stationary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.676
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4877
NKM-1	GDSC Cell Line Gene Expression Profiles	1.0	1.69872
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997209
MRPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04811
hydroxytoluic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70999
retinal pigment epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.24208
KMS34	DepMap CRISPR Gene Dependency	1.0	2.83245
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03542
BRD-K83276573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35511
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32054
ONS76	DepMap CRISPR Gene Dependency	1.0	4.14163
MYLA	DepMap CRISPR Gene Dependency	1.0	3.09101
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1331
GLO1_OE_GDS4991_546_mouse_anxiety disorders	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.84369
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.203361
NT5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22265
BRD-K25559116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11787
BRD-K47083242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15552
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.819774
BRD-A66025870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.26323
NUR77	MotifMap Predicted Transcription Factor Targets	1.0	null
C1orf226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44164
noticeably	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A3L1-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DV-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75712
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.20792
steroid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
BRD-K47391428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2555
MTFMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06997
HNF4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92538
Intraciliary transport particle B	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.96
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.582384
ACAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93467
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060936
BRD-K49932469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82013
CORL279	CCLE Cell Line Gene CNV Profiles	1.0	1.47872
SIK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52137
cone-rod dystrophy 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.159
C17orf75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48651
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.961104
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1179
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.856868
BRD-K78252315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17421
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
MIO-M1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
retinylamine	CTD Gene-Chemical Interactions	1.0	null
late-onset retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
BRD-A61864215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.42706
BRD-K11016405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56665
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46426
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SQ-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARPE-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.281
EDARADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95107
Mature chylomicron	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
COMMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05983
BRD-K85672685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41093
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.28639
hsa-miR-4709-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
regulation of hormone levels	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7726-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65392908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19076
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0747
BRD-K72066653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07111
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0359
TP53	ChEA Transcription Factor Targets	1.0	null
ELAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13599
GJB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81416
20436685-ST5-2	GeneSigDB Published Gene Signatures	1.0	null
CRCGN008_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16535
ACTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49671
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6312
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.6586
membrane part	GO Cellular Component Annotations 2015	1.0	null
Kinesin II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.262
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0545
CDCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2292
retinoid metabolic process	GO Biological Process Annotations 2015	1.0	null
HES6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33827
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.71561
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.37502
ECSCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59844
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
TNRC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84361
RIGI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11081
POLR2H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27915
Vitamin A and Carotenoid Metabolism(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
hsa-miR-122	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059985
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27895
Retinoids	CTD Gene-Chemical Interactions	1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Leber congenital amaurosis 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.714
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.651371
cyclopenthiazide-4229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ABRAXAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12141
mRNA_CBX8_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Rod photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.686
NANOGNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45501
BRD-K17405621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58912
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.65362
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37378
hsa-miR-4491	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35177
H3K27me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38314
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19638
HUG1N	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.49544
GUF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57822
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
JHOS-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00137
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.942022
KCTD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69071
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24127
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04533
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12819
choroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.472315
Sensory Perception	Reactome Pathways 2024	1.0	null
alltransretinal	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-02A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-8474-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90449
steroid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K08199068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51415
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78993
HUPT3	CCLE Cell Line Gene CNV Profiles	1.0	1.58581
E2F7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88793
ZMYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70065
BRD-K79184750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24965
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975127
BRD-K71575663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03152
NCIH1650	DepMap CRISPR Gene Dependency	1.0	2.04065
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00469
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor	GO Molecular Function Annotations 2015	1.0	null
BRD-K67862892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01403
neural retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.95384
Leber congenital amaurosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.465
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.921072
BRD-K93176491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17635
SNUC1	DepMap CRISPR Gene Dependency	1.0	2.58334
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A8OC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48113764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33271
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4712
TPGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13199
SON_KD_GDS4448_35_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
retinol dehydrogenase activity	GO Molecular Function Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Platelet dense granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
Liver hepatocellular carcinoma_LIHC_TCGA-BC-4072-01B-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.940993
BRD-K14449601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06947
mRNA_NR2F2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Ciliary membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.278
FBXO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67931
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.7233
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5504
BRD-K57639176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09523
Perturb_15805_KO_Atf4_SRP350242	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209072
CTCF	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4314	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1473
DDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67607
SMYD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30658
fulvestrant-367	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K13627844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84062
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.794
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8022
Vitamin A and carotenoid metabolism	WikiPathways Pathways 2024	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.95773
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.915157
C1orf174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60358
hek-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216325
HEL	CCLE Cell Line Gene CNV Profiles	1.0	1.86102
prolonged	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28112
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.21501
BRD-K89116076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41944
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF202	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47465
BRD-K91057865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09979
MARCHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38745
MRPL37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52868
hsa-miR-576-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
UFSP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35324
UACC257	CCLE Cell Line Gene Expression Profiles	1.0	2.51203
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.586578
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.791165
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.437181
SMARCA4	ChEA Transcription Factor Targets	1.0	null
BRD-K76350099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01806
SKRC31	CCLE Cell Line Gene Expression Profiles	1.0	1.74571
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.36109
BRD-K51697562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52518
NR4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07529
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7194
NADPH	HMDB Metabolites of Enzymes	1.0	null
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66833
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18074484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40499
BRD-K16605233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31208
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4367
AKIRIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46594
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K24443173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01529
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11554
Retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.587
IQGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46925
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.927845
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
cone-rod dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.642615
HIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13165
BRD-K20009653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14333
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fundus dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.09713
response to stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K29662535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21083
HEK-293H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.074
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.30649
BRD-K10513366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34762
BRD-K54007898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15212
PVRIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41553
BRD-K93601851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09183
BRD-K47143916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44593
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Smooth endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
BRD-K20199304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54145
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
MALME3M	CCLE Cell Line Gene Expression Profiles	1.0	3.40789
BRD-K34931072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23544
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2008
WDR18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90108
steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor	GO Molecular Function Annotations 2015	1.0	null
MOLM16	CCLE Cell Line Gene CNV Profiles	1.0	2.93884
Melanosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.444
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.114822
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19473
SDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36863
Viral cardiomyopathy_Myocardial tissue_GSE4172	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.50788
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54894
degeneration of macula and posterior pole	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.08915
SW837	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86388
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82628
flumethasone-pivalate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36747
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15453
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34258763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59861
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18535
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6474-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13515483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63007
MRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47498
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050294
BRD-K09367542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59358
GNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70501
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.10231
hsa-miR-541	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R8-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70696
Pseudopapilledema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
CTBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33791
H3K27me3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDMYZ	DepMap CRISPR Gene Dependency	1.0	3.20125
RES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.949
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56441027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35919
Hermansky-Pudlak syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.681
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4175
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	1.05494
TJP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95041
APEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68043
SARS-CoV MA15_Day4-PFU-10^3_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.44608
Retinal ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
BT483	CCLE Cell Line Gene CNV Profiles	-1.0	-1.378
hsa-miR-3650	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39171
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.929693
ASB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5895
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30471
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
MYL12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64777
Lateral plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.861
MELHO	CCLE Cell Line Gene Expression Profiles	1.0	2.25281
HEYA8	DepMap CRISPR Gene Dependency	1.0	2.4487
FAM47E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44114
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068135
HOXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5436
MEC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55511
guanadrel-2575	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BICR22	CCLE Cell Line Gene Expression Profiles	1.0	1.57685
spinalcordupper	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.03274
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.06196
The canonical retinoid cycle in rods (twilight vision)	Reactome Pathways 2024	1.0	null
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7614
BRD-K32208085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79949
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19829191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23866
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RNF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9765
NCIH727	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70027
BRD-K28905117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03522
blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.171785
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.825715
HMGN3_02_45	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	5.35755
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.13349
Vitreous humor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.032
OV90	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39822
moxonidine-4084	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45984211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17705
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF655	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68124
Chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.927
ZFYVE26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.452
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3486
Diseases associated with visual transduction	Reactome Pathways 2014	1.0	null
Retina	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K27599706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27219
primary alcohol metabolic process	GO Biological Process Annotations 2025	1.0	null
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4409
CRCGN010_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26308
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30951
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.33343
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16143
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.203
Prostate adenocarcinoma_PRAD_TCGA-EJ-5508-01A-02R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-378g	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.048
EZH2	ENCODE Transcription Factor Targets	1.0	null
BRD-K90040724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2629
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
BRD-K04257723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00622
ZFHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53867
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100419_TCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50112
GATA1-19941827-MEL86-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAN1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7068
QGP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052525
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.829949
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27732
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
segment	GeneRIF Biological Term Annotations	1.0	null
detection of visible light	GO Biological Process Annotations 2015	1.0	null
CCM2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74786
p3h3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
T98G	Achilles Cell Line Gene Essentiality Profiles	1.0	1.39099
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5929
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MM-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-138	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
SP100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27229
C15orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00018
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862209
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K88369626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1418
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	1.42353
HSC-2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.41322
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K39979171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06619
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
lipid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
TUBA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40287
AMMECR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60612
SENP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76378
hsa-miR-4534	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05543
LIVF001-015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59597
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.97058
MDAMB468	CCLE Cell Line Gene CNV Profiles	1.0	2.41926
kidney	GTEx Tissue Gene Expression Profiles	1.0	2.18987
bone marrow-derived macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377245
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088463
ZNF331	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86301
TSPAN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40616
ARHGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79696
BRD-K20171002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20697
BRD-K87176777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0298
cone-rod dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.408
Lung squamous cell carcinoma_LUSC_TCGA-77-8130-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.326067
FANCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32228
NZOV9	DepMap CRISPR Gene Dependency	1.0	5.01832
FMNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33753
hsa-miR-4691-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K24178822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00362
BRD-K79547691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46941
BRD-K69987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05026
BRD-K07981644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73003
Sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.405
LUZP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61949
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.511
Mueller cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
SH3GLB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69872
Bonemarrow	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31381
NCIH747	DepMap CRISPR Gene Dependency	1.0	2.95424
ECC10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49868
BRD-K48593237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36279
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1315
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9263
unlikely	GeneRIF Biological Term Annotations	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.41672
EVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8845
MG63	CCLE Cell Line Gene CNV Profiles	1.0	1.56003
CCDC113	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50246
KATOIII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60555
microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.563238
GSE234767,GSE234769_0_v_4_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retinol metabolism	KEGG Pathways 2026	1.0	null
light	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MT-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PNMA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48356
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84052780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29405
PURA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2762
novobiocin-342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69480055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55508
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060253
TMEM248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23288
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06251
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.55502
HCC1195	CCLE Cell Line Gene CNV Profiles	-1.0	-2.45102
HCT15	BioGPS Cell Line Gene Expression Profiles	1.0	0.857049
REST-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF139	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55035
LS123	DepMap CRISPR Gene Dependency	1.0	2.37082
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.931469
iloprost-427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K63758740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13547
Retinal ganglion cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.252
IGR-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BBSome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.988
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11554
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
IGLON5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44853
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3707
SELENOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72902
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65098
Photoreceptor Degeneration	DisGeNET Gene-Disease Associations	1.0	null
BRD-K12396271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.9276
iPS-18 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.20643
HEYL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0443
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050474
BRD-K20028734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01948
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2887	DepMap CRISPR Gene Dependency	1.0	4.37627
LNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35106
NCIH1975	CCLE Cell Line Gene CNV Profiles	1.0	1.43378
LRR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2517
FBXL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03132
NCO2	CCLE Cell Line Gene CNV Profiles	1.0	1.46439
MYC-18940864-HL60-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
isoetharine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29321
BRD-K34929471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81869
SLC9A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59097
Myopia	HuGE Navigator Gene-Phenotype Associations	1.0	null
TBCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72068
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050427
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201251_2_v_5_coumarin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37595074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48573
Bothnia retinal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.722
UT7	CCLE Cell Line Gene CNV Profiles	1.0	2.49643
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7390-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null