association	dataset	threshold value	standardized value
BRD-K97921950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03252
midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.90924
PIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66409
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.186
BRD-K51974360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50335
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86854
HDAC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86667
DCBLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02665
T-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.221
Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39113
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.5851
GTPase activator activity	GO Molecular Function Annotations 2025	1.0	null
paraventricular nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20475
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13202_KO_Hdac3_ERP123505	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.65433
MTF2	ChEA Transcription Factor Targets	1.0	null
HS944T	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.40891
NCIH1651	CCLE Cell Line Gene CNV Profiles	1.0	1.39275
NARF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4741
cancer	GAD High Level Gene-Disease Associations	1.0	0.295739
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.80469
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10128
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.989
NOTCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.191
furafylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89287
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ovary_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14701
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02449
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.59166
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074078
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10671144__F7	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K31716785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20702
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826501
GNA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70579
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65962
HCC1428	CCLE Cell Line Gene Expression Profiles	1.0	1.37038
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.178
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13519
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846068
SULT1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22215
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Table_S5C_Downregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
SETD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.58792
POU3F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43402
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r7bp	GeneRIF Biological Term Annotations	1.0	null
periventricular stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42335
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7202
FCHO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15277
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
LRF	MotifMap Predicted Transcription Factor Targets	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCCPAN2	CCLE Cell Line Gene CNV Profiles	1.0	1.45452
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03234
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z3-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35017
C18orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51912
BRINP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23236
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.965487
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15173
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
rod spherule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.809359
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Cell cortex region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.406
Midline group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34011
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49275
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6234
lovo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.316224
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19747
ARHGEF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54809
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.279
arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.093875
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09968
Medial group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31721
regulation of signal transduction	GO Biological Process Annotations 2023	1.0	null
BRD-K11502669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07225
ABCA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12008
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45249
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33851
C-81 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KYM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.08325
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928492
DNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18047
internal granular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08651
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5522
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29122
interact	GeneRIF Biological Term Annotations	1.0	null
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.18708
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66991
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09191
UMR-106 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
FTCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71641
FAM50B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73755
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K39962926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44786
BRD-K33768761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51473
GARIN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0548
HES6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33827
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03165
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87035
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65961
TSPAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18793
ZNF124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75582
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38357
citiolone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17912
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995006
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951839
Esophageal Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.865577
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
sclc21h	HPA Cell Line Gene Expression Profiles	1.0	1.09624
Postsynaptic specialization	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.633
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Synaptic cleft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.211
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976949
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Umbilical smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
LU-134-A	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53752
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.51545
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878744
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
RELCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2816
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46039
CHP-100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
POMGNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91306
KLF4-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.22152
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.977782
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
BCL7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17247
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.64144
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_H3K27me3-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.26136
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32688
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.562863
Measles Chicago-1_24Hour_16492729_GSE980	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.55527
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75474
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03098
SDHAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76864
neuron part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Phospholamban complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.209
GTEX-XBED-2526-SM-47JYD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17318
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QXCU-0126-SM-2TC5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20596
PAK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97385
BRD-K36882679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2061
EML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3767
CCDC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35793
LRP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0923
FOXK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7147
cSARS Bat SRBD_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.81375
HOXD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52224
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.879977
DEP domain	InterPro Predicted Protein Domain Annotations	1.0	null
MED21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80863
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.160387
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-2526-SM-4BRUR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10147
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GNAI1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIRT1_KO_GDS4895_43_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05949
GTEX-Q2AG-1226-SM-4GICA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904237
NB10	DepMap CRISPR Gene Dependency	1.0	5.93368
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49918
pancreatic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.107602
p190	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.158
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90697693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17193
DCAF12L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05593
GTEX-S4P3-0926-SM-4AD54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03307
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
OVKATE	CCLE Cell Line Gene Expression Profiles	1.0	1.39334
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Opiate dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36099605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29591
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.7926
CBF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.937
P12-ICHIKAWA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26436
RNF26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.21284
GTPase activator activity	GO Molecular Function Annotations 2023	1.0	null
PMC10107781-NAN-49-0-s002.xlsx-NGS68_MBNL2_KO-vs-WT_log2FC0-4-GRCh37_87_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sublayer 6b of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44763
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20363
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.488923
BRD-K55434198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13687
NACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64353
Dorsal peduncular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07653
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.920639
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41302
Primary somatosensory area, trunk, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07504
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36386
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.342971
Photoreceptor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.091
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30212
YIPF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42726
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863304
BRD-K23669327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07335
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.292079
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
GSE209598_1_v_2_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.254902
A-Netherlands-602-2009(H1N1)_12Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.61432
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neoplasm Recurrence, Local	HuGE Navigator Gene-Phenotype Associations	1.0	null
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11077
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.06408
C-75-6399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HE-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEx Lung 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	4.45093
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.872562
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7421
G protein-coupled receptor heterodimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
GSE234647_1_v_2_regorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94978
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.996057
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.246448
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26892
GATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08335
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17610834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00245
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B4-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endometrium_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.867339
Myometrial Relaxation and Contraction Pathways(Mus musculus)	WikiPathways Pathways 2014	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03978
Perturb_13844_KD_Hs6st1_SRP371980	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.99109
Late endosome lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.51
NIPBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70421
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21477
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
CLN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61648
BRD-K47878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21572
SHISA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07408
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
Lung adenocarcinoma_LUAD_TCGA-05-4405-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21914
brl1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.021
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.850964
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14539_KO_Kras_SRP311976	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.31721
VAX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70224
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0524
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
IRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32762
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PNPLA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9134
SMURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80486
BRD-K85697068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77955
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1743
BRD-K48171978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47077
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856373
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11952327-media-1.pdf-26-ENSG00000130751_NPAS1	Rummagene Transcription Factor Associations 2026	1.0	null
GABRA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5047
corpus striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.6182
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
CFPAC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.41674
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2466_KD_NDP52_SRP345458	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.90337
PEMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72622
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.843
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913515
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE220	DepMap CRISPR Gene Dependency	1.0	3.05337
cerebellar white matter	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42386
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11909
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.09646
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE9375	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.13557
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIRT1_KO_GSE28790_47_mouse_brain (3 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83103
GSE98579_0_v_1_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FANCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32228
MACIR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04738
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38478
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.930959
JARID2	ChEA Transcription Factor Targets	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49019
UPCISCC116	DepMap CRISPR Gene Dependency	1.0	2.22537
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4575_OE_Haspin_SRP271373	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.45467
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4792
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29427
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44696
benzonatate-5435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4764-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
outer plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.2238
Piriform-amygdalar area, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27619
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16678
OSGEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43253
JRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72508
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04882
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1513
Infralimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47271
BRD-K72234025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33477
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896816
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22119
HCC2218	CCLE Cell Line Gene Expression Profiles	1.0	1.50002
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.072
CTAGE15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43132
GSE129241_1_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68375
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.117
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35833
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859739
BRD-K90697690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08956
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95656
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65285
hsa-miR-3187-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K50746465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75418
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893902
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00214
hsa-miR-1182	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
abnormal cone electrophysiology	MGI Mouse Phenotype Associations 2023	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08289
BRD-K88758204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04167
GTEX-TML8-1626-SM-32QOO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861344
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08047
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16223
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22071
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3166
SARS-CoV NSP16_Day2_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.00461
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061644
FAM78A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6839
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.05129
TMEM132A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.01305
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.855422
Perturb_1084_OE_IRF1_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.50533
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64728664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51639
BRD-K61651560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4828
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880529
G-protein gamma-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.407
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SMCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95653
ZNF329	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25489
BRD-K72843176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95823
iodoquinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8611
BRD-K45077605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21429
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31483891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5237
GSE166004_3_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6658
FASTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20835
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.838789
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29215
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10638173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21401
PMC7687904-41598_2020_75770_MOESM1_ESM.xlsx-SP2-Gene_SP2	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2928-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985957
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63384
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980902
GTEX-V955-2526-SM-4JBJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08578
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051265
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.0438
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23874
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22937
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5875-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEC23IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47641
GSE207471_2_v_0_btla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13485
GTEX-P4QS-2026-SM-3NMCG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.181
SW-1573/S1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.887979
CTSV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35538
LRRC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65158
calu-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.48223
Perturb_13912_KD_TARDBP_SRP169127	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.8665
USP51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.585
16166195-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
JHOS-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54711
ENTREP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44102
Perturb_5308_KO_Tet1/Tet2/Tet3_SRP101434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.69111
MMS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09281
Cerebellum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18621
NMCG1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46824
Side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.922
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14961381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09536
Orbital area, ventrolateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30408
BRD-K83952475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13624
UACC257	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.80353
colonic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081285
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46601
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57332
U2-type catalytic step 2 spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
NFU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46613
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.438
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.721
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046598
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982417
TAL1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL33	CCLE Cell Line Gene CNV Profiles	1.0	1.54256
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
NCI H226	BioGPS Cell Line Gene Expression Profiles	1.0	0.835201
BRD-K20895937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04933
SNU182	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73144
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
DUSP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48641
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854442
ovarian cumulus cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.282837
Perturb_4521_KO_Mapk1/Mapk3_SRP281895	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.09429
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.77072
TP53INP2_OE_GDS5054_387_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K09275191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17184
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.95076
MZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.951609
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78003637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28798
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.997766
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RORC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21168
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15979
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
colonic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121177
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48234
NAXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30545
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
capan-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.497657
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	151.536
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.006
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4368
RAB3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89972
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08905
DPPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67047
GET4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27982
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08303
hsa-miR-637	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Arbuscule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1857
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55258
NEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.52002
superficial stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03099
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864745
PMC7593556-mmc5.xlsx-high_ShearStress-YBX2_YBX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17395
SELENOI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41635
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3061
TCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78903
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-8195-01A-31R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VJ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF488	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80461
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K51641263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70131
GTEX-NFK9-0426-SM-2YUNK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927205
KLHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13088
Lobule III, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.22381
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.10208
TSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30993
Rkip1_KO_GDS4331_15_mouse_C57BL/C pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_ESRRB_19136965	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NIPSNAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22408
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308251
UACC893	DepMap CRISPR Gene Dependency	1.0	2.78091
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09345
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53421673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10756
beta-catenin destruction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.688486
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80933
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04544
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62608
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4XJ-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GAS2L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81719
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4149
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-1.11222
EPHB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45914
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22548
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.848979
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.05646
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62552
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31565
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Postsynaptic density	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.626
BRD-K62957665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45982
CDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48134
DICER1_KO_GDS4504_582_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77752
ZNF721	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89135
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WDR77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57201
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.10441
hsa-miR-4291	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859568
rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.178682
ARL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05959
SLC33A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57832
Perturb_13188_KO_Rbfox2_SRP216887	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.51234
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864745
UNC13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10042
YARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09631
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112761,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03234
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CEP164	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.93729
MPV17L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68554
Tapetum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
TXNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36776
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876948
FAM124A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82174
GTEX-SUCS-1726-SM-32PM8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866787
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2279	CCLE Cell Line Gene CNV Profiles	1.0	1.7597
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	2.56578
LRRC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45431
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H520	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65757
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OPTN_KD_GDS2892_268_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NH12	DepMap CRISPR Gene Dependency	1.0	2.02843
Culmen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2723
regulation of gtpase activity	GO Biological Process Annotations 2015	1.0	null
inner SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.894869
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.924058
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60695
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.544
articaine-3138	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951394
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vegetative cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.787
Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.025
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04251837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22494
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
NG-108-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.196
cell projection part	GO Cellular Component Annotations 2015	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
PTMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26185
MLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86597
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.903796
hsa-miR-711	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37441
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920796
NDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47326
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	1.4487
NUDCD3	Pathway Commons Protein-Protein Interactions	1.0	null
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040711
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73613
BRD-K98251998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66565
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09696
PEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30401
SNUC1	CCLE Cell Line Gene Expression Profiles	1.0	1.35727
Dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.033
Mitotic septin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
TINF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09194
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054685
HO1U1	DepMap CRISPR Gene Dependency	1.0	2.98611
Brain Lower Grade Glioma_LGG_TCGA-S9-A7J2-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.842368
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S341-0726-SM-4AD5R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35018
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1072
dendrite terminus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.941052
5666823-609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
negative regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-C9-A480-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Asymmetric synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.621
SEC61A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81406
Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ribonucleoside triphosphate phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.601686
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-up-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
POMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42073
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33725
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16444
heterotrimeric g-protein complex	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7911-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19L-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17797
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934952
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.80644
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053624
LOUNH91	CCLE Cell Line Gene Expression Profiles	1.0	1.38359
LYRM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.95925
KIF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4704
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060707
cell periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.533309
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GP2D	Achilles Cell Line Gene Essentiality Profiles	1.0	1.32647
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961864
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_35_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.892561
colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094084
NUP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60224
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60009
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16237
Prostate adenocarcinoma_PRAD_TCGA-M7-A71Z-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	243.649
BRD-A30962679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80858
BRD-K69569958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29463
PAPLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35972
Perturb_13648_OE_miR24_SRP067253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
TFB1M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98331
HAPLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96248
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23107
GSE186223,GSE186224_6_v_2_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17656
TSNAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8543
outer SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8298
Neostriatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.43
Leaf disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.026
sublayer 6a of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45098
bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049915
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02565
pancreatic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103183
posteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23357
COS-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.373
LMNTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29219
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72718
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866692
H2BW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51563
retinal rod	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.56005
BRD-K27600134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02213
PMC4783780__F8	PFOCR Pathway Figure Associations 2024	1.0	null
PMC3368389-fphys-03-00095.nxml--RGS_protein_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4292	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78987
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nerve	GTEx Tissue Gene Expression Profiles	1.0	0.961226
HSC-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57883
Extrinsic component of cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.002
Endocytic patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.749
BRD-K11404512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71788
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09241
Presynaptic active zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.401
Lung squamous cell carcinoma_LUSC_TCGA-58-A46M-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JMJD1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.01058
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Refractive error	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19743
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.898455
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
PCDHB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78783
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34989
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965853
ovary	HPA Tissue Gene Expression Profiles	-1.0	-0.928254
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69062
VPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28196
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53752
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
negative regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
G alpha (i) signalling events	Reactome Pathways 2014	1.0	null
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF146	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71855
Perturb_14674_Mut_GCK_SRP089943	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.17346
ZNF460	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81345
GTEX-QV44-1026-SM-447CG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854305
levallorphan-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04991
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45774
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EMSY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7316
nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.404418
CLPTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39108
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TSPAN17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60282
SUZ12	ENCODE Transcription Factor Targets	1.0	null
TMEM63B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6275
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07064
TJP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02454
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24353
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844459
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75731
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829033
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067543
Osteoporosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
TOMM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61215
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Hoxc13_OE_GDS1890_174_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
suramin sodium-7524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_8646_KO_Fndc5_SRP319261	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.3455
CTNNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84713
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
ATF2_S_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.687
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24479
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU869	CCLE Cell Line Gene CNV Profiles	-1.0	-2.08527
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
Phellogen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9146
Autosomal recessive spinocerebellar ataxia 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20247
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0849
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3909
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.70481
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	261.524
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6325
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6883365__F2	PFOCR Pathway Figure Associations 2023	1.0	null
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24478
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	342.992
ChIP_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CKMT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88018
lateral ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.267791
GSE166004_1_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.14945
Uveal melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.99586
Pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.975
BRD-K44521151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76113
H3K4me1_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A05422420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29695
BRD-K59392325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64794
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0111
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TSSK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16493
dbtrg.05mg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.582
VCAP	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00039
STAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60235
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62403
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60518
SARS-CoV MA15_Day7-PFU-10^3_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89807
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
scale	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.55249
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48986
PKBalpha_KO_GDS1784_196_mouse_Embryonic fibroblasts (MEFs) - 24h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36585
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15224
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.85415
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
LTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19775
Calcium regulation in cardiac cells	WikiPathways Pathways 2024	1.0	null
STAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16191
BRD-K79658624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32345
Prelimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.71208
Pleated septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.1999
GTEX-XAJ8-1126-SM-47JYA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883725
NELFE	ENCODE Transcription Factor Targets	1.0	null
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IL-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
ZNF114	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59162
BRD-K85908443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42873
Contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
GTEX-XQ3S-1226-SM-4BOPP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07379
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of hydrolase activity	GO Biological Process Annotations 2023	1.0	null
BRD-K56525823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86565
Cerebellar granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.046
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00257
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.91492
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91868
BRD-K51234905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2438
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZBED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26123
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	359.245
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARID3A_02_50	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61005
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17033
laryngeal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.265038
MOLT16	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56329
BRD-K97562463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43773
GIPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77349
dorsal part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14915
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68751
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.79
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K27me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99284
BRD-A59995060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63923
Amacrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.27
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77962
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23368
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_InDel-F5-Thygro-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
termination of signal transduction	GO Biological Process Annotations 2015	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.369628
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5ML-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.78924
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964379
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31881
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.427
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.3474
PLEKHA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23718
RH28	DepMap CRISPR Gene Dependency	1.0	2.1438
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
DKMG	DepMap CRISPR Gene Dependency	1.0	2.35075
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40514
BRD-K56881825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6716
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8062-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.151196
Perforation plate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92957
Perturb_13649_OE_miR27_SRP067253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.32217
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33809
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	4.54821
NAA50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28522
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.38215
RCOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47088
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.199681
SNU1327	DepMap CRISPR Gene Dependency	1.0	3.49045
colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.162109
MFSD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75952
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	1.46504
Lung adenocarcinoma_LUAD_TCGA-69-7974-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior cingulate area, ventral part, 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20858
CORL23	CCLE Cell Line Gene CNV Profiles	1.0	1.90176
gtpase regulator activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28264
GSE178255_5_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GCIY	CCLE Cell Line Gene CNV Profiles	1.0	2.42473
KMS26	CCLE Cell Line Gene CNV Profiles	1.0	1.34906
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916771
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.289938
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.073758
cefalexin-4654	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937974
SPTY2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78526
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989781
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8422_KO_DGAT2_ERP114849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PIERCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16973
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HUH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43242
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1048	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42391
Congenital stationary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.184
ZMYM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.479
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.853678
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24061
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4355-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF295	DepMap CRISPR Gene Dependency	1.0	2.9369
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C8-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23728544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39215
HNRNPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41982
CELSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58066
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.253291
HUH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.25793
BRD-K85659077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07552
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.5398
KYSE-140	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09124
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81565
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42794
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27909
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLR25	CCLE Cell Line Gene CNV Profiles	1.0	2.45694
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28157
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53176
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850749
Chromaffin cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
BRD-K48408404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16059
STRA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8907
CALM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98828
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51805
LRP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07486
BRD-K45762887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18049
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.762922
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04861
Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974801
SRPRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51216
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
BRD-K39397248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59886
Striatal neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.754
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52247
ribbon synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.463997
COPS7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43988
CFTR_Deficiency_GDS1843_191_mouse_Lungs - Animals examined at 3 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
larynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.155025
HCT116	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34406
ACHN	CCLE Cell Line Gene CNV Profiles	1.0	1.83826
GTEX-XOT4-0826-SM-4B66Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917351
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1060_Mut_Esr1_SRP087718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.31693
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05025
Usher syndrome type 2C	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SIKE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73937
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE264621_1_v_3_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06545
Perturb_14524_KO_LRHt_SRP009598	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.17294
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.789
TIMM17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88712
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04286
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF518B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66288
diflunisal-4210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18466
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15516
MBOAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36822
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PDE6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48694
personality disorder	GWASdb SNP-Disease Associations	1.0	0.687069
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95296
BRD-K43624274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05916
ATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67878
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22755
EWSR1	ChEA Transcription Factor Targets	1.0	null
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08883
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4734
ASH2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58569
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33212
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952906
GSE80098,GSE80366_0_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
METRNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11368
CCK81	DepMap CRISPR Gene Dependency	1.0	4.46815
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13285_KO_Mettl14_SRP182641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.5902
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19831
testosterone-2649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8328-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19347
Mesolimbic dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
B4GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83391
ZR75_1	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847923
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
PMC2981398__F1	PFOCR Pathway Figure Associations 2023	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
Infertility, Male	CTD Gene-Disease Associations	1.0	1.24056
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67893
cortical cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.209513
BRD-K30795375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39988
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09318
layer 6b of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03051
Spitzenkorper	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.892
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23295
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.229839
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.362
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03125
Prelimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45267
BRD-K05639803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71402
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDC42EP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20028
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05386
PTGES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83307
SLC16A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6463
ZNF561	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99818
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTPase activity	GO Molecular Function Annotations 2023	1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
HTRA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28086
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845629
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
psychotic disorder	GWASdb SNP-Disease Associations	1.0	0.295275
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18094
Cardiofibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.152
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.616
FGF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71699
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33739
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.851378
BRD-K39068840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43642
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17046
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
BRD-K24984327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07238
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3816
TMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75865
ALG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4666
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24486
Perturb_8560_KO_Kpna1_SRP124160	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.04847
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35295
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Gustatory areas, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36305
PSMB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62805
PODXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08513
KLF4	ChEA Transcription Factor Targets	1.0	null
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16083
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
BRD-K10317744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03754
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8127
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80379
photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.272633
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
697 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.684
CTCF	ENCODE Transcription Factor Targets	1.0	null
SNU668	CCLE Cell Line Gene Expression Profiles	1.0	1.67688
Piriform-amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43783
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908969
VMRCRCW	CCLE Cell Line Gene CNV Profiles	1.0	1.58171
ECGI10	CCLE Cell Line Gene Expression Profiles	1.0	1.88748
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071409
KAT2A	ENCODE Transcription Factor Targets	1.0	null
successful	GeneRIF Biological Term Annotations	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03234
MIN-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K74506898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05169
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.70731
velnacrine-6651	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898959
Primary visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03791
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEP_3B2_1-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
immature ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25259
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
APBB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98765
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3206
C2orf49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87266
pirinixic acid-495	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.485693
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13541
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.953738
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.72283
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89857
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TXNDC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78441
Taste bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
PUS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83635
LY-294002-501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53918
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09706
Mediodorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27503
4-hydroxyphenazone-1915	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.973615
TGFB_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K14442101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15922
Ocular hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
LbetaT2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
MFE296	CCLE Cell Line Gene Expression Profiles	1.0	1.65796
RPMI 8226	BioGPS Cell Line Gene Expression Profiles	1.0	0.870365
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.902046
Metabolism of proteins	Reactome Pathways 2024	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.030745
GTEX-X4EO-0126-SM-3P5YN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1979
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960851
carcinoma, squamous cell; head and neck neoplasms; neoplasm recurrence, local; neoplasms, second primary; squamous cell carcinoma	GAD Gene-Disease Associations	1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPVG-2826-SM-4B66J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14675
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inner SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54284
SP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77759
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14621
Taenia tecta, dorsal part, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3928
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41512
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09682
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88833
TRAFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4646
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GT-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8659
ARHGAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89471
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07138
Perturb_13198_KO_Dax1_ERP123502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.16471
496100296_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26504
ENTREP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67309
BRD-K17339982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02188
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02236
PMC11732233-mmc1.pdf-195-MYNN_MYNN	Rummagene Transcription Factor Associations 2026	1.0	null
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37319
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DUS4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59294
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07565
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58480962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73893
ZNF704	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09562
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53777
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.991006
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.9343
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.54217
axon terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.142291
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-612	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1184	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83764
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22033
KLK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77914
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18578
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847923
COX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57156
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46886
PMC5522997__F9	PFOCR Pathway Figure Associations 2023	1.0	null
CHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24583
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of hydrolase activity	GO Biological Process Annotations 2015	1.0	null
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.855673
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.301758
Perturb_10236_KD_Kat7_SRP174052	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.57774
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50977435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65293
RER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58459
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67023
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sensillum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.217
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE153124_4_v_3_dsg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-A47B-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cebpa_22442349_pbmc_lof_human_gpl570_gds4407	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.820652
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85966
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057115
BRD-K87386611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14713
DUSP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83114
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Striatonigral neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.269
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
c1195	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46905
Polyketide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.205
PHF8	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34147
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2068
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.508
FBH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97042
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58903
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.856198
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Chaperonin-mediated protein folding	Reactome Pathways 2024	1.0	null
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.37
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3001-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01864
Central amygdalar nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08104
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA41-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07075
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.392
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257358
[Ni-Fe] hydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.56
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05858
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TIMM17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19948
retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.093303
H4C8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99858
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08409
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73302
Agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59303
PMC11799275-Table1.docx-5-GLI1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01875
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14085
hsa-miR-3138	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.1115
photoreceptor	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.857995
ACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32837
RNF167	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47629
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64417
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HX-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6914
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, upper limb, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33186
Inner plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.462
Huelle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.535
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067288
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MFE296	DepMap CRISPR Gene Dependency	1.0	4.50736
SKPNDW	DepMap CRISPR Gene Dependency	1.0	4.68761
Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-02A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5319
extrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.941162
cell projection part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.241132
extrinsic component of cytoplasmic side of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEx Colon 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	17.629
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065694
PRRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13279
pancreatic duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.1939
Postsynapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.634
A-CA-04-2009(H1N1)_18Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.43727
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82846
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	3.37612
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35556
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892737
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
ASCL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82826
Cell cortex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.628
bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.115956
GTEX-T5JC-1226-SM-4DM7C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00933
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
GTEX-Q2AG-0626-SM-2S1PV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22627
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.739
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.837268
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4756-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59194147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31822
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1263
MTOR_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
RTBDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41829
CBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00168
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.219
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31534
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05668
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5417
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7657
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cytoplasmic side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.06144
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
catalytic complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.001651
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926537
Morphine dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_2-up-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
Lobule III, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47843
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213410_0_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5631
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ASCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84396
ECHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1269
BRD-K32862383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17369
Fatty Liver	CTD Gene-Disease Associations	1.0	1.06552
side of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.007697
BT483	CCLE Cell Line Gene Expression Profiles	1.0	1.56498
Perturb_17260_KO_Gja1_SRP247546	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Lobules IV-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2736
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DUS3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20478
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior cingulate area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.33797
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	0.933238
COX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29694
ADAM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11634
GSE179868,GSE180330_1_v_2_ddx21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868511
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1066
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9666
HOS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GABPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82939
tanespimycin-521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078466
NARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86605
MSI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45606
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25289
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
duodenum_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.864895
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00126
Perturb_15641_KO_Shh_ERP023558	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.90499
PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-KLF4_correlates_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
ERGIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75805
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4924
Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spermatheca	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
peripheral nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.23227
NKX2-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80208
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.51919
GTPase activity	GO Molecular Function Annotations 2025	1.0	null
MAML3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24835
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29447
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1304
PRR14L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91647
IARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73886
BRD-K50127933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30676
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06194
PMC6459557-pbio.3000201.s012.xlsx-Sheet1-FOXD1_FOXD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V955-1726-SM-4JBHF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836374
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
GALNT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97123
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56988
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01219
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94433
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20335
SKN3	DepMap CRISPR Gene Dependency	1.0	5.03395
Perturb_9246_KO_Lin28b_SRP300815	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03709
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10727
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0507
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ELOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8271
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075201
Woronin body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06363
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43869
HS821T	CCLE Cell Line Gene CNV Profiles	1.0	1.43042
HEC50B	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
LN18	CCLE Cell Line Gene CNV Profiles	1.0	1.95469
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13447_OE_PAX8_SRP189244	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.64309
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bone remodeling disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66007
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56873
CACYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00997
Ventral striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
TEKTIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02369
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895664
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.31179
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7929
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1121
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2908
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.029
cellular_component	GO Cellular Component Annotations 2015	1.0	null
PMC6883365__F1	PFOCR Pathway Figure Associations 2023	1.0	null
abnormal rod electrophysiology	MGI Mouse Phenotype Associations 2023	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dendritic knob	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.275444
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62267
BRD-K95501793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14035
TMEM9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28271
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Rif1_KD_GDS4943_243_mouse_F1 embryonic stem cell (ESCs) line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K45936761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79411
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.212182
Perturb_9695_KO_GPNMB_SRP382180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.89891
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25015
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15994
ABHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80006
BRD-K37506332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23041
personality disorder	GWASdb SNP-Phenotype Associations	1.0	0.588907
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K82292504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60926
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.39166
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01034
lung adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19934
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.10523
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.18654
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.906915
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
18234966-Table2	GeneSigDB Published Gene Signatures	1.0	null
ZNF503	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98105
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298165
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66833
EAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37889
anterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06184
Contractile actin filament bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.352
SLC17A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45532
FBXO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4544
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEx Stomach 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	5.16175
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862447
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.878666
Intermediodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73654
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SELENON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60743
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.84441
BRD-K85110576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31344
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51478
intact	GeneRIF Biological Term Annotations	1.0	null
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981136
CRACR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02303
MYOG	ENCODE Transcription Factor Targets	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-7.82121
ID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40117
Anterior hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.34331
BRD-K72770355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6227
SIRT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69338
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-1326-SM-48FDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12482
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16946
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.41182
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Spore wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
TCF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81716
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07566
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	PANTHER Pathways	1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03258
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
UBE2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63733
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31812
Amylin receptor complex 3	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
GTEX-NPJ7-0011-R9a-SM-2TC5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830341
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81711
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19103580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03379
IRF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22513
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63517
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02878
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.79474
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YJU2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65728
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52564
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
SCH	DepMap CRISPR Gene Dependency	1.0	5.1987
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09376
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7927886-2019_239970_BOUSSAID_SUPPL_TABS2.xlsx-GATA1_targets_-_genesets-Unnamed_1_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TTC30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27043
dorsalrootganglion	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959423
Actin filament bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.386
PRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66904
BRD-K13265046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03997
MEL-JUSO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53554
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18735
MDAMB134VI	CCLE Cell Line Gene Expression Profiles	1.0	1.97319
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842842
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.998
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fg86	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.387
putamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15792
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	4.2786
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22125
TRMT9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65783
LRRC75A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52331
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6344081-elife-40364-supp8.xlsx-PLZF-kd_2d_Diff_Vs_Ctrl_2d-diff-Symbol_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17060750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56955
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856362
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF764	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26413
DISP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28511
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.842027
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19117
Lung adenocarcinoma_LUAD_TCGA-99-8025-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
CRCGN010_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05419
TBX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12984
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
TMEM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15158
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00063
TCCSUP	DepMap CRISPR Gene Dependency	1.0	4.88848
G3BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33874
TAL1	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.84938
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.087
GSE237040_6_v_3_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07133
THAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54927
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
USP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78711
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
GOLGA8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27963
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21031
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.3354
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832379
communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.221793
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24592
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.18439
Myometrial relaxation and contraction pathways	WikiPathways Pathways 2024	1.0	null
Locus ceruleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.216
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.59691
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3792
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
TAL1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBRG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47612
NACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56753
HCC-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SSBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71114
BRD-K28774883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87716
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65392756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61818
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00172
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18042
MMAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23527
ARPC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14833
Perturb_12910_KD_FOXA1_SRP313175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.45427
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	8.41243
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mesocorticolimbic dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.99586
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1833
Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ECC12	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73427
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06223
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GOLPH3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25121
BRD-K59765110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01128
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XRCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12926
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MY-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FMNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14481
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.1617
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
functionally	GeneRIF Biological Term Annotations	1.0	null
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55664
NCIH2066	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6421
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00632
Rod spherule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.758
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	214.84
large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.161912
BRD-K89805341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2022
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Table_S4C_Downregulated_genes_in_lesions_and_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_the_mammary_duct_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
inner SZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.862768
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE184087_4_v_5_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
RTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48882
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48859
g-protein beta-subunit binding	GO Molecular Function Annotations 2015	1.0	null
lobelanidine-5080	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41651
lung adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.184602
CDK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03474
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K84391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49
Anteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14845
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01335
brain	GTEx Tissue Gene Expression Profiles	1.0	1.18674
TRIP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76107
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.40656
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Puncta adhaerentia	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.515
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.905567
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	251.003
EGR1-19032775-M12-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.910722
Proteinuria	CTD Gene-Disease Associations	1.0	1.03084
GTEX-R55F-0226-SM-48FCI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4314
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2039
CAPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30982
pralidoxime-6443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOXB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90726
Prostate adenocarcinoma_PRAD_TCGA-KK-A8I9-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50593511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83137
TRAF3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79478
SVIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17533
GTEX-XQ3S-1026-SM-4BOPJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922761
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02647
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80775
Zona glomerulosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX2	JASPAR Predicted Transcription Factor Targets	1.0	null
acacetin-3942	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00649
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NHE3_Deficiency_GDS3323_599_mouse_Colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Heterotrimeric G-protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.004
Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.3061
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89072
GTEX-RM2N-1126-SM-48FCY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987448
pancreatic ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.393819
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30845
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67065
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.906626
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44432
BRD-K55606442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76975
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50357
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.876537
MAST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4084
X-linked juvenile retinoschisis 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
throat	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073795
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.889636
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16078
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.252564
laterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30086
layer 6 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1671
TET3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37345
BRD-K76342376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62823
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.425726
BRD-K89931949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75025
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49022
Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3467	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.8775
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.65657
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.326067
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13782363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04727
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962244
CRCGN017_MCF10A.TP53.M_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00117
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32804
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11264
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65799
Mean corpuscular hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04853
LU-65	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-VUSG-1026-SM-4KKZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877935
Septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
Serotonin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Presynaptic active zone cytoplasmic component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.391
HSPBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23845
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
KCMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9768
TCF3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.740915
MAFK_02_183	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.80735
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26559
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10432
Elaioplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3042
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superior colliculus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.875073
NEIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14452
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978158
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13922
Stoma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.173
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20403
Perturb_13244_KO_Mettl14_SRP182641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.30948
bretylium tosilate-5020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11191
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53822
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00357
Anterior cingulate area, dorsal part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60689
neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56684
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911777
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	1.40332
membrane	GO Cellular Component Annotations 2015	1.0	null
Ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.905
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.923287
NCIH446	DepMap CRISPR Gene Dependency	1.0	2.71995
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.985299
Perturb_14089_KO_SMARCA2_SRP295674	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A42Z-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDQP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64592
disease	GWASdb SNP-Disease Associations	1.0	0.028129
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32312
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33851
BRD-K42968051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11901
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053507
ANKRD27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80227
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	1.0	0.890443
BRD-K15997423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17702
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.850255
kinetin-2511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cone photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
UTP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25922
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05478
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.893024
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Site of polarized growth	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.328
POLR2A	ENCODE Transcription Factor Targets	1.0	null
USP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09168
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88661
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72236
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RQ-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
JARID2-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27272
BRD-K90877053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32801
Lip epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09461
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77377
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
reticular formation of CoPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07191
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM72D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87484
positive regulation of GTPase activity	GO Biological Process Annotations 2023	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.029
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27865
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sublayer 6a of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09617
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04086
Apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.194
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pravadoline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21003
BRD-K64257929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.6089
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15053
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
NFYA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68629
H3K27me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEx Thyroid 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	5.52185
SLC25A37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69879
DEAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5434
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15558
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44307
MIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76034
LOUCY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55418
GTEX-T8EM-1826-SM-4DM7F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930901
Leaf sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
inner SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12995
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03143
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
HENMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39744
Perturb_821_OE_Rspo1_SRP325709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.86317
NAA80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68067
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16441
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77996
IGR39	CCLE Cell Line Gene CNV Profiles	1.0	1.36893
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91775
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.90966
ACSM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44604
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.180937
Adenocarcinoma	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE218500_0_v_3_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10128
adrenalgland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967276
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31134
SU8686	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.68546
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.982549
basophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191338
MARK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04578
Neurosecretory vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.526
ZFP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50094
NEUROG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85637
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.034
CMAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9379
CRTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60389
KYSE510	DepMap CRISPR Gene Dependency	1.0	2.56808
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1235
Midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.306
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71261
Tongue-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	0.099366
BRD-K48634117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05655
nucleoside-triphosphatase regulator activity	GO Molecular Function Annotations 2015	1.0	null
Stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
Cone cell pedicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.872
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.856894
dendrite	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Lung adenocarcinoma_LUAD_TCGA-78-7539-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7407
SREBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15328
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.77535
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.971984
Leaf epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.464
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35605
GTEX-SIU8-0326-SM-2XCDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0883
Perturb_6702_KD_PLAGL2_SRP164912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ATG4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94866
BRD-K25583354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02707
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
METTL21EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6985
SPG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73123
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828848
RPL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92319
CHST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51241
Perturb_5228_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP194961	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.03278
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49277
Perturb_3146_KO_Mrfta/Mrtfb/Myocd_SRP388810	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.3775
intracellular part	GO Cellular Component Annotations 2015	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22929
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76505
KM12	BioGPS Cell Line Gene Expression Profiles	1.0	1.16962
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03289
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36157
STAT1	ChEA Transcription Factor Targets	1.0	null
KLHDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32471
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59842
rectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090804
ZCCHC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16834
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.899837
Perturb_17679_KO_l2LsL_SRP228817	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cortical cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.516
Retinitis pigmentosa 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.991307
BRD-K74789550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90376
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04713
TIFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24654
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5085
cortex of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03099
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26785
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.794
HdhQ111/111_Knock-in_GDS4534_744_mouse_Striatum and cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Fragile X syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27652
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03285
TMEM127	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75062
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.82221
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11275
DBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99375
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HAUS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77891
WDFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31885
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	3.15147
Peeling skin syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51217
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0326-SM-2TF6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02629
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.3811
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
CYTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.67639
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
RGS, subdomain 1	InterPro Predicted Protein Domain Annotations	1.0	null
PSMD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57071
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.853788
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.57758
BRD-K05868476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25189
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.964575
Cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.329
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
SOD2_KO_GDS1080_128_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_EZH2-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A26583774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34275
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51304
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854562
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7332
ARL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79443
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.5582
IGSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9006
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4665-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50465
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF573	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02291
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58028
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875344
MAX	ENCODE Transcription Factor Targets	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.7493
MAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05567
granulosa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.252919
horizontal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391931
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67779
GLIPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69777
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33848
negative regulation of signaling	GO Biological Process Annotations 2015	1.0	null
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IL11RA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52129
SLC48A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17293
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.764
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61876
COLO320	DepMap CRISPR Gene Dependency	1.0	2.8534
PMC10247733-41408_2023_863_MOESM2_ESM.pdf-424-RFX8_RFX8	Rummagene Transcription Factor Associations 2026	1.0	null
promazine-3927	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K70712582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08647
KTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91101
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.918
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56825
AEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82601
GLUL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22583
KCTD19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10601
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.5928
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.983755
maprotiline-6676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CENPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27972
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.59262
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.295
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.96416
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CYBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64775
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TMEM92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7817
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84433
SBDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86424
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYK_druginhibition_287_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.49978
Hyperplasia	CTD Gene-Disease Associations	1.0	1.25214
LS123	DepMap CRISPR Gene Dependency	1.0	2.06344
PHOSPHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9306
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50609
GTEX-NPJ8-1426-SM-3MJHR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16655
abnormal rod electrophysiology	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-4796-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.562863
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838268
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75662
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53264
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.346777
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6331
CAOV3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.36135
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10807
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973248
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Presynaptic cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.39
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
Field CA3, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0572
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.1465
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05139
Perturb_3958_KO_GSDMB_SRP350967	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.64871
GSE178255_3_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39573478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2203
TMEM248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09638
Actin cortical patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315861
BRD-K11517399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31737
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.33934
septal organ	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.22593
PMC4431731-pgen.1005211.s002.xlsx-ERG_TRISOMY-Unnamed_2_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
NUP133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35876
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212936
POR_KO_GDS1678_761_mouse_ILEUM	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14711
MRGBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17353
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.67445
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27914
KLHL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54109
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44807762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58146
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34656
Hi-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
RACK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92807
Congenital stationary night blindness 1B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.168
ZBTB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31552
retinoschisis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.02397
GTEX-RTLS-1226-SM-46MUP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22887
DCHS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45654
Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ribonucleoside triphosphate phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
LN235	Achilles Cell Line Gene Essentiality Profiles	1.0	1.06625
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58077750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09761
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927574
BRD-A39521712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91785
BRD-K13069055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04786
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892165
SIN3B	ChEA Transcription Factor Targets	1.0	null
lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.597961
MIER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35569
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterior midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	271.383
JRA - Juvenile rheumatoid arthritis_Peripheral blood mononuclear cell_GSE7753	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.92053
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
SNU449	CCLE Cell Line Gene CNV Profiles	-1.0	-1.592
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54744
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26361
hsa-miR-4525	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10217
colorectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095286
SKMEL2	DepMap CRISPR Gene Dependency	1.0	2.55308
peripeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20002
BRD-K91490997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16947
RAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17238
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TU-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068949
GTEX-UPJH-0626-SM-4IHJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988833
CCDC102A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49627
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07614
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3902-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66324291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2554
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71668
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.133014
intermediate stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09014
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85863
UMUC7	DepMap CRISPR Gene Dependency	1.0	2.37248
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07881
negative regulation of g-protein coupled receptor protein signaling pathway	GO Biological Process Annotations 2015	1.0	null
sensory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.36268
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Essential hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31977946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24702
Night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.144
CUL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72991
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33597
HIBADH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86132
COPS7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49322
MAP4K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58107
PSMB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64333
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07526
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066716
BTRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44794
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.894048
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.99757
SK-MEL-30	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43005
dorsal terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03319
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.69171
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.806
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.30801
Mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.953
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.979922
Red Blood Cell Count Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40143134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81141
Weight Loss	CTD Gene-Disease Associations	1.0	1.08231
BRD-K44292107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35828
GSE245405,GSE245406_0_v_1_sox9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-2426-SM-3MJHL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931647
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19772
BRD-K39561340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17074
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3131
PMC6883365__F2	PFOCR Pathway Figure Associations 2024	1.0	null
CALU1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.43413
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.85308
DLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04089
SCC4	CCLE Cell Line Gene CNV Profiles	1.0	1.87159
purification	GeneRIF Biological Term Annotations	1.0	null
BRD-K75429775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43538
UTP14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49516
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSL1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43208
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CW-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ileum smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050359
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86065
Brain Lower Grade Glioma_LGG_TCGA-WY-A858-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fat_x1.V2	HPA Tissue Sample Gene Expression Profiles	1.0	0.903048
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847923
PEBP1_KO_GDS4334_617_mouse_Pancreatic beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03061
GTEX-RU72-1126-SM-2TF6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07805
THAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71039
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20791
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97494
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.12184
BRD-K91615044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43434
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.986933
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
midbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.45567
NOMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35034
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03305572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22648
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AtT-20 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.04
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54515
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_12_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
UQCRQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78244
BRD-K30548577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29061
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060097
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-XUJ4-2726-SM-4BOQ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24596
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94102
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.84198
TARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06046
hsa-miR-4425	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CD59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84623
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91491
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828274
Primary somatosensory area, mouth, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56988
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KIAA1549	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26678
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98558
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Signal Transduction	Reactome Pathways 2014	1.0	null
cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.111977
GTPase regulator activity	GO Molecular Function Annotations 2023	1.0	null
Olfactory tubercle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K56520129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18866
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
r1 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26844
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Epithalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.073
PAICS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1694
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
la96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
BCL11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63618
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.53267
PLXND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50865
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46769
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.373899
PMC7572916-mmc5.xlsx-1000_Genomes-RGS_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
gbeta5free	GeneRIF Biological Term Annotations	1.0	null
prochlorperazine-5575	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4954
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896092
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.262025
neuron part	GO Cellular Component Annotations 2015	1.0	null
20436685-ST4-2	GeneSigDB Published Gene Signatures	1.0	null
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.96134
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12206
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.32861
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21
Winged helix-turn-helix DNA-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
REM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14913
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44466
BRD-K94476572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38857
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96991,GSE97117_5_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LUC7L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92546
H3K27me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
genistein-638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16355
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
Cortical actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.103
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-558	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K68305833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5249
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78518
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064559
Signal Transduction	Reactome Pathways 2024	1.0	null
SARS-CoV MA15_Day2_None_GSE49262	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.45717
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19935
BRD-K81175414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33119
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.85259
SSC4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29846
KASUMI1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.24368
DB	DepMap CRISPR Gene Dependency	1.0	4.79591
laminin-8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.541
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16295
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.962205
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05485
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1048
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10388
HCC1954	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13292
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77692
anterior paraventricular nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63475
GTEX-RWS6-1026-SM-47JXD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66856
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MKN45	COSMIC Cell Line Gene CNV Profiles	-1.0	-5.12655
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41681
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4703-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04426746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24449
GTEX-T2IS-0926-SM-4DM5B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928741
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PACADD188	DepMap CRISPR Gene Dependency	1.0	3.8303
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10742
PLXNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37045
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60886
BRD-K14925361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33592
cSARS Bat SRBD_60Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.2967
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heterotrimeric g-protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CL1-0 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.115
Septin ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39943
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36527
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14785
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44391
U2OS	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61613
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34752
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.51545
SIAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47984
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.0766
KYAE1	DepMap CRISPR Gene Dependency	1.0	2.02049
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.05138
DGCR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51886
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE60837_2_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4202
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.29673
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.65054
extrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
SPIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37488
SPRR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57296
ZNF662	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54819
Myometrial Relaxation and Contraction Pathways(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36917
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
BRD-K22338979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23293
PRDM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57811
cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.124182
GTEX-XV7Q-2226-SM-4BRVY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863774
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847923
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829056
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34077
MYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41047
MFE-296	GDSC Cell Line Gene Expression Profiles	1.0	1.91442
Calu-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.0394
SCLC21H	CCLE Cell Line Gene Expression Profiles	1.0	1.57218
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83278
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7304
ZNF454	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23142
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15824
BRD-K21747676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10845
negative regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
Perturb_11920_OE_IRF3_SRP114539	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
AMBRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73803
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.551425
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HF-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.54927
Telodendria	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
TRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9685
CDPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67608
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
SUPB15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36007
CRCGN016_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2629
PMC7927886-2019_239970_BOUSSAID_SUPPL_TABS2.xlsx-GATA1_targets_-_genesets-Unnamed_3_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A894-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AKTIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22066
OTUD7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61852
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.328834
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
DNAJC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71075
Root tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.272
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF451	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63515
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83679
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.118005
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
BRD-K32759631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20524
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.938614
COLO684	DepMap CRISPR Gene Dependency	1.0	6.13155
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02881
ALDH3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73839
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01223
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78912
TFDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59695
PRELID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11171
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IKZF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09307
PLB985	Achilles Cell Line Gene Essentiality Profiles	1.0	1.84918
IGF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12623
BRD-K43111300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18708
Myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
wc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
Retinal cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.986
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.09065
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.51545
BRD-K79435297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01931
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.47108
Orbital area, lateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20156
vision/eye phenotype	MPO Gene-Phenotype Associations	1.0	null
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10249
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03003
Lung adenocarcinoma_LUAD_TCGA-97-A4M1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.292436
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.72
GNAI3	Pathway Commons Protein-Protein Interactions	1.0	null
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19001
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043218
MEL270	DepMap CRISPR Gene Dependency	1.0	2.49483
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.8634
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UT-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.962858
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_18Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.16166
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.51365
FTH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01361
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-193a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38424
PMC7572916-mmc5.xlsx-1_Prevalence-RGS_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3853
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
TRIR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33316
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Photoreceptor disc membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.248
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
Coleoptile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
ACOT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46338
ADAMTS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01367
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00738
MM253	DepMap CRISPR Gene Dependency	1.0	3.40846
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81801
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.826496
Perturb_9219_KO_Mecp2_SRP056141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22926
BRD-K98170574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05445
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985352
Lung adenocarcinoma_LUAD_TCGA-55-A4DG-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05204
C21orf91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.399
BRD-K26263099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52413
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30737
Suprachiasmatic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
Scolopidium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.33
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12545
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.14665
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Field CA3, stratum oriens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01454
SAFB2_02_150	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.45943
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZFHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7075
rgs11	GeneRIF Biological Term Annotations	1.0	null
RHBDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5291
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.36
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03884263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64416
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.42074
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
AARSD1	Pathway Commons Protein-Protein Interactions	1.0	null
MAGOHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26018
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88218
biological regulation	GO Biological Process Annotations 2015	1.0	null
BRD-K24369860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25843
PHACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51943
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913217
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997386
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71574
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4341
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096833
mantle zone of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14886
ACAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23863
HAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52291
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.947435
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45433
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12928
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38848
outer SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15654
MMAC-SF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49472569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58931
Posterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16996
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16306
CHD2	ENCODE Transcription Factor Targets	1.0	null
LSM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15465
Lung adenocarcinoma_LUAD_TCGA-99-8028-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53352
MTARC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92453
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.823914
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81885
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70215
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.849052
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.99971
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29512
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32817
Caryopsis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.985
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RALGDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29013
PMC10148553-12935_2023_Article_2932.nxml--Role_of_RGS_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
ATP5MC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56087
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RHBDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.481
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85314
NR4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98694
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	128.665
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_14475_KO_Trim28_SRP305340	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.86194
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.961863
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51243
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11939
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995006
Perturb_12095_KD_Pten_SRP169507	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.2977
STX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34673
PEBP1_KO_GSE31150_52_mouse_pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94477
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
Perturb_1076_KO_Mr1_ERP107271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.56273
PMC10107781-NAN-49-0-s002.xlsx-NGS68_MBNL2_KO-vs-WT_log2FC0-4-symbol_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25084
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32775
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19779
Perturb_11912_KD_Arntl2_SRP063609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.87291
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08899
DOK	DepMap CRISPR Gene Dependency	1.0	4.21838
SNU1033	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59446
RT4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34462
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
Calcium Regulation in the Cardiac Cell(Mus musculus)	WikiPathways Pathways 2014	1.0	null
BRMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74475
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052534
NCIH716	CCLE Cell Line Gene CNV Profiles	1.0	1.46362
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848443
BRD-K11596967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31193
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	158.368
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.5529
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.945514
AURKA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28113
Pontine nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
ZNF770	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29315
SKRC20	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05782
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971954
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45318
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04874
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13484
MDAPCA2B	CCLE Cell Line Gene Expression Profiles	1.0	1.52973
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7945
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
ERG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23452
g-protein beta/gamma-subunit complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.549773
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2559
NXPE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30472
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
KIF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.234
Shoot apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
GLUD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77879
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.80644
Primary motor area, Layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00578
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19052
RNF31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09561
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46308
A-CA-04-2009(H1N1)_3Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.26711
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GL-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33826
hsa-miR-1275	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8098-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BECKER	CCLE Cell Line Gene CNV Profiles	1.0	1.4189
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-1826-SM-4JBIL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07674
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4971-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE135309_0_v_1_tcf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21079
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64775
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HLA-E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50257
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12685
SDHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17371
BRD-K19418944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21423
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921337
EC-GI-10	GDSC Cell Line Gene Expression Profiles	1.0	1.50915
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43318
BRD-K36726853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30433
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.71929
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049924
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78946
fat_e	HPA Tissue Sample Gene Expression Profiles	1.0	0.975003
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31216
PPIH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89792
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21645
GTEX-XUW1-0626-SM-4BOP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00287
signal transduction	GO Biological Process Annotations 2015	1.0	null
termination of g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_13250_KO_Mettl14_SRP182641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.05442
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976733
BRD-K47821225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00604
TMEM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86836
CAND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5071
STAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32101
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.258917
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.711
MARK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19005
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1-19032775-M12-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K61560971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41878
Phellem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
16651409-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A0XA-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1285	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K61209548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18917
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	227.944
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.61689
UCHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4165
ARMCX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1461
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37728
BRD-K15008902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49676
BRD-K35213218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11631
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_SUZ12-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30408
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HUH6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76421
CEBPB	ENCODE Transcription Factor Targets	1.0	null
P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72194
sf-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.206299
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226091,GSE226092_3_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.918121
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.86801
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19217
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15534
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86232
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84721
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ENDOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40128
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43693
BRD-K22983069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20663
Peripheral nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.993
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CYB5D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44657
icSARS CoV_7Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.73069
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12832
bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051641
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964752
GNAQ	Pathway Commons Protein-Protein Interactions	1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	1.40471
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04034
pRb_Deficiency_GDS3176_605_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.66017
TULP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00643
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.254239
LMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06828
BRD-K65081680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58146
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70W-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96764878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14002
Perturb_15119_KD_DNMT3B_SRP054246	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.30822
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0493
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68578
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47562
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19099
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059992
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
flutamide-4539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DYRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15694
Cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
Dorsal peduncular area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43594
MAP3K21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64453
H3K27me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.40676
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00106
Lung adenocarcinoma_LUAD_TCGA-62-A46U-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GCNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29361
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18402
FBXO21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62149
Mesophyll cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
BRD-K77922263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1576
CHD1	ENCODE Transcription Factor Targets	1.0	null
colonic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07899
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NUMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63121
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894537
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GPCR downstream signalling	Reactome Pathways 2024	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3940_KD_IRGM_ERP122050	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.58502
Guanylate cyclase complex, soluble	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIVF001-028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12512
Infralimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19209
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358174
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046841
CCC5	DepMap CRISPR Gene Dependency	1.0	2.11678
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4255
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868601
BRD-K90697691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13362
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.69619
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal cone electrophysiology	MPO Gene-Phenotype Associations	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24052
EGR1	ChEA Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNARE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.287
PMC7450273-mmc2.xlsx-ST12-Unnamed_4_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07313
SUZ12	ChEA Transcription Factor Targets	1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67797
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12474
SCA1_Knock-in_GDS3544_561_mouse_Cerebellum - 4 Weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076493
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.837
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86141
microbody	LOCATE Predicted Protein Localization Annotations	1.0	null
GIMEN	DepMap CRISPR Gene Dependency	1.0	3.74118
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28018
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
Lobules IV-V, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23551
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8181
ZIC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12611
BRD-K55105453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33885
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.906454
NDUFV3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85668
BRD-K65196043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40229
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Claustrum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00284
sf-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.537812
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
pertussis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.524588
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978276
HOXB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5948
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70196
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.91239
cell part	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.5364
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.675
BRD-K59093791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2759
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14321
heterotrimeric g-protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.06144
CRCGN016_MCF10A.WT.HP_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10235
GORAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04719
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.529
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33856
mediodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0498
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.05555
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16415
MAP1LC3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98488
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28008
khellin-1922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02285
LBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42309
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835458
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864745
Prelimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
SW780	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99141
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.845551
ORC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77766
Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Caudate putamen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.096
molecular function regulator	GO Molecular Function Annotations 2015	1.0	null
GSE213228_1_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21987
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.950083
SLC37A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82539
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2257
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EWS-ERG-20517297-CADO-ES1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.50635
iloprost-496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	4.68746
pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.250663
18787207-TableS2	GeneSigDB Published Gene Signatures	1.0	null
AMFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93165
BRD-K81782447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11073
PMC8481886-Table_1.xlsx-A_subsets-UC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
differentially	GeneRIF Biological Term Annotations	1.0	null
NRBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37288
NCI-H23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE235234_2_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12815
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232631_0_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62170825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66452
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47784
TMEM179B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98841
ZMYND19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99101
Neoplasms, Second Primary	HuGE Navigator Gene-Phenotype Associations	1.0	null
ZHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.04641
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38726
Head and Neck Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
OVK18	CCLE Cell Line Gene Expression Profiles	1.0	2.40869
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31134
hsa-miR-4740-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
ZNF768	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17939
duodenum	HPA Tissue Protein Expression Profiles	1.0	2.2243
SNU878	CCLE Cell Line Gene CNV Profiles	-1.0	-2.35138
schizophrenia	GWASdb SNP-Phenotype Associations	1.0	0.681679
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3146
Cytoplasmic side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.992
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pollen tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
RHOU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91677
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30503
ZNF395	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31617
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07238
SAP30BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33334
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11394
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90797
BRD-K88321606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14262
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50708
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Outer nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.31
GNA11	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892325
Perturb_5306_KO_Tet1/Tet2/Tet3_SRP101434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.01997
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	171.462
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20078
Sinoatrial node disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15138
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25383
ORAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33011
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29762
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26306
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
PMC10175786-Table4.XLSX-Sheet_1-GSE9750_AND_GSE7410_NOT_GSE63514_NOT_Ferrotosis_genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Posterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18434
mevalolactone-2718	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
ETFBKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00912
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DICER1_KO_GDS4504_584_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051149
SP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.96589
GNB5	Pathway Commons Protein-Protein Interactions	1.0	null
PARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56103
SIRT6	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72908
TCTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04191
Pituitary gland tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.815
BRD-K80972048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2416
LY-294002-2687	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bipolar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.331
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79465
SNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.10632
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.92044
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09188
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72646819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07954
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25012
GSE239436,GSE239441_0_v_1_keap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06989
GNAO1	Pathway Commons Protein-Protein Interactions	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15264
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.7742
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.94026
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06663
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869925
Flocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07164
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.51
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
RIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47495
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38169
SK-N-SH	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.908176
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.2111
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-2.46948
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-3.35613
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88833
cerebral gray matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.531879
GSE152055_2_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFC3H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77217
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.999613
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111011
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM94	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05046
N-acetyl-L-leucine-6462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Extrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.677
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73431
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43796
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
granulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.138514
SWI5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3412
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19405
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91371
bipolar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.88373
EPS8L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55221
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10227
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864745
MELHO	DepMap CRISPR Gene Dependency	1.0	2.26481
BRD-K29771129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24242
496100641_PCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13057
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00039
inferior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07058
BCAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62999
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50609
KRTCAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.416
Barrett Esophagus_Esophageal Tissue_GSE1420	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.6106
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.104
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948046
PMC6883365__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18601
regulation of g-protein coupled receptor protein signaling pathway	GO Biological Process Annotations 2015	1.0	null
Photoreceptor cell cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.453
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68333644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57537
BRD-K18737347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09034
TMEM191C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71508
TMEM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52091
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06776
NRBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36633
mRNA_MYOD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048139
HCV_8week+IFN-a_None_GSE37715	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.71006
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27414
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.746
GSE143643,GSE143644_2_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSS	CCLE Cell Line Gene Expression Profiles	-1.0	-2.1705
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.0971
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13837
Tegmentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.239
NALM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88962
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.386
MESSA	CCLE Cell Line Gene Expression Profiles	-1.0	-2.80425
FAM169A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18502
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29106
hsa-miR-4721	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58835
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18151
BRD-K48739735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68714
BRD-K11577431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35993
NCI-H28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.88555
BRD-K40061857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02785
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4681
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PEX11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57445
BRD-K74314059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42435
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.87631
neck	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068597
MYL6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53356
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50684
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06343
PPP2R5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08814
SLC16A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31552
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979993
Perturb_1665_KO_Rigi/Mda5_SRP119759	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.38984
DNAJB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54798
THTPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6788
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GSE128333_4_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3290552-pone.0032232.s005.xls-ErbB2-KD_vs_NT-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SOX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63008
GFAP_OE_GDS1488_254_mouse_Olfactory bulb of 23 day old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05097
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Apoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.309
catalytic complex	GO Cellular Component Annotations 2015	1.0	null
Mesothelioma_MESO_TCGA-MQ-A4LI-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46042
TGFBR2_knockout_292_GSE46150	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.84713
GCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20759
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
GRM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79193
BRD-K23405293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19393
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21893
LN443	CCLE Cell Line Gene CNV Profiles	1.0	1.33491
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.6696
16484322-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K10775155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12963
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0389
BRD-K34258713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04705
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29965
THY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06086
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
THRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72324
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.50456
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.080751
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC4783780__F8	PFOCR Pathway Figure Associations 2023	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH23	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53851
MED12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1988
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T8-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial (magnocellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81373
Lung adenocarcinoma_LUAD_TCGA-05-4244-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.7761
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13545
GSE143643,GSE143644_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52728
ARG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7088
ABHD17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77244
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
schizophrenia	GWASdb SNP-Disease Associations	1.0	0.78442
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	PANTHER Pathways	1.0	null
GSE245390_2_v_1_acss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CELSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90182
tyloxapol-5672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048297
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.867847
VCAP	DepMap CRISPR Gene Dependency	1.0	3.79319
Lung transplant rejection_Trachea_GSE3418	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.14184
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.901315
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5341
PMC7687904-41598_2020_75770_MOESM1_ESM.xlsx-SP2-ENSGID_SP2	Rummagene Transcription Factor Associations 2026	1.0	null
FOXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89058
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K24321898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4569
Perturb_11488_KO_Foxp1_SRP158103	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.95561
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932728
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
H2AC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26536
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.751
Phloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.435775
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.23369
BRD-K88449712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00531
peroxisome	LOCATE Predicted Protein Localization Annotations	1.0	null
CHAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96183
COGN305	DepMap CRISPR Gene Dependency	1.0	2.84892
BRD-K61039403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73073
TMEM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61246
Perturb_4305_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44043
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.8048
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.722886
rectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089811
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.339
THBS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17429
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.986953
NCIH1048	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50896
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8326-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948888
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93745
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17617
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40775
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0177
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19203549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50184
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0463
BRD-K45037973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15086
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72602
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83055
Perturb_13644_KD_Trim28_SRP126388	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.14937
EIF3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12489
CORL279	CCLE Cell Line Gene Expression Profiles	1.0	2.18103
APPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35992
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02446
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64922
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Field CA2, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1328
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
neuron projection	GO Cellular Component Annotations 2025	1.0	null
COLO201	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20304
A3-KAW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K35128023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45718
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Panicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.072
IFNLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61181
CRCGN016_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29585
PAPOLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07098
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.82762
Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.705
MYOD1	ENCODE Transcription Factor Targets	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.284
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.247
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
enzyme regulator activity	GO Molecular Function Annotations 2015	1.0	null
HAUS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.563
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04719
BRD-K18561719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12884
BRD-K77663497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01474
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.1557
BRD-K87803080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44944
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854802
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Root quiescent center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
PMC11216188-peerj-12-17616-s013.pdf-258-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
SNUC4	CCLE Cell Line Gene Expression Profiles	1.0	2.05084
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.866356
Radicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
Lung adenocarcinoma_LUAD_TCGA-J2-A4AG-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00361
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4744
synapse part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.110914
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XMD1-0526-SM-4AT4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2517
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC113	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50246
XRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40648
hexestrol-5776	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.45839
NCIH1618	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54514
CDK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56723
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of GTPase activity	GO Biological Process Annotations 2023	1.0	null
Central medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12826
all	GWASdb SNP-Phenotype Associations	1.0	0.030699
ZC3H7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87995
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05086
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31851
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	1.0	1.87456
Cone matrix sheath	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
MRPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18341
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46357
GTEX-XOT4-0326-SM-4B66S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46681
Perturb_4779_KD_Trim24/Trp53_ERP016337	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.45735
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36387
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62905
Lung adenocarcinoma_LUAD_TCGA-73-4658-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YAPC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8646
GSE126402_1_v_0_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.606
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067566
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.836331
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5328
Perturb_8423_KO_DGAT2_ERP114849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Axillary bud meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32705
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ZFAND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57956
Pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.09
Sick sinus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
SIRT1_Deficiency_GDS4895_316_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ZBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94666
Perturb_12803_KD_Mtnr1a_SRP314803	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.25571
MLH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72213
H3K27me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBNA1BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64546
HOOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67357
UMUC16	DepMap CRISPR Gene Dependency	1.0	2.92177
brain	HPA Tissue Gene Expression Profiles	1.0	1.06218
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86045
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear MIS12/MIND complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
GRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62026
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969253
Photoreceptor outer segment membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.950887
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.135
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RGS domain	InterPro Predicted Protein Domain Annotations	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11588066-pnas.2410331121.sapp.pdf-63-BPTF_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13567
Prelimbic area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78897
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09309
MED29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14503
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
rhombomere 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12049
TEKT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92586
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68416
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948978
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-2.01006
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56467
BRD-K52796804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78116
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34899
DMBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00705
negative regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056751
gtpase activator activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831343
BRD-K66793411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14893
prostate_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.936876
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40608
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.00082
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ls-174t cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.388912
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.947537
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TROAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08497
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.209
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.914557
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A6K9-06A-41R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.829
9+0 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.362
APH1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93395
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77385
BRD-K99078335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21971
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22075
FOXD4L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53311
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
C1orf226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39627
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.965533
LN229	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
MOB3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75314
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0911
CAOV-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
GLYCTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8059
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9353
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53868
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
Heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
ARRDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01839
NRK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	233.022
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066798
PANC-03-27	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47262
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15433
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10633
NCIH854	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74528
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14492
WWTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06132
RAB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21832
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07959
ILRUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15494
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.853312
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC37	Pathway Commons Protein-Protein Interactions	1.0	null
Germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.551
PERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23623
SLC5A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68375
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55634
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03032
BRD-A21168039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04434
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99452
MDK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86016
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-2526-SM-4AT57	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861627
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.903975
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33495825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38927
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31306
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186124,GSE186128_1_v_0_dnmt3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74537
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.50788
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TP53INP2_OE_GDS5053_312_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13194_KO_Dax1_ERP127280	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.83219
21152935-TableS1	GeneSigDB Published Gene Signatures	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.94917
BRD-K43414987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39916
PABPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93199
DU-4475	GDSC Cell Line Gene Expression Profiles	1.0	1.90905
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer SZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40172
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8404
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31706
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42912
GSE100217_1_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82734
Perturb_13196_KO_Dax1_ERP127280	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dystroglycan complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985352
CerebellumPeduncles	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.960379
Brain Lower Grade Glioma_LGG_TCGA-TM-A84L-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84878
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66886
G alpha (i) signalling events	Reactome Pathways 2024	1.0	null
Root hair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.056
ATG9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60037
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26944
SLC9A3_KO_GDS3323_495_mouse_colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.41182
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-939	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95759
BRD-K55662526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02091
Extrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.815
TERF2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61352
BRSK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90723
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9589
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
496100384_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50729
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
certolizumab pegol_homo sapiens_gpl570_gse33585	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Taurine dioxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
rara_21911359_f9_teratocarcinoma_lof_mouse_gpl1261_gds4294	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.317316
Heroin dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
extrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
sublayer 6b of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61031
JHOM2B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41707
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JHH-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89072
CLCN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44025
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18578
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
ZSCAN30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48889
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
GTEX-T2YK-0326-SM-4DM7D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15149
BRD-K58643762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65527
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42391
Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17162
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2171	COSMIC Cell Line Gene Mutation Profiles	1.0	null
20436685-ST5-2	GeneSigDB Published Gene Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45869
Intracellular canaliculus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.518
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845162
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997122
NCIH2172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80923
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833343
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.78015
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058604
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IPO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82304
cell cortex part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.163641
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11077
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61018
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982258
CDIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78014
SLC26A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65616
estradiol_homo sapiens_gpl14550_gse35034	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glycated hemoglobin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.830103
Simple lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12912
JUP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68334
blood	GTEx Tissue Gene Expression Profiles	-1.0	-2.09862
GTEX-WRHU-0626-SM-3MJFI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836599
Substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
HS3ST3B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93463
GTEX-S4Q7-1426-SM-3K2B9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851532
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828061
MEIS2_02_30	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61005
Autosomal dominant hypocalcemia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
UBLC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7203
E2F6	ENCODE Transcription Factor Targets	1.0	null
mRNA_OTX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_4471_KO_Prdm12_SRP334439	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.30849
Septin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06001
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8442-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Malignant Transformation	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.172
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitotic spindle pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.931
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
reticular formation of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35149
Dorsal peduncular area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29271
GATA1-19941827-MEL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34459
Inflammation	CTD Gene-Disease Associations	1.0	1.39338
FLII	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16954
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.895195
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3131
DVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11516
furegrelate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14703
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39319
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57254
LPCAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95875
CCHCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19446
oa1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08633
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894537
GTEX-U3ZH-1626-SM-3DB74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880985
SLC35E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3758
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30503
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00235
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
Yersinia enterocolitica food poisoning_Peyer's patch_GSE4764	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.48793
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6022
AFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80874
YY1	ENCODE Transcription Factor Targets	1.0	null
NCKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98288
GSE189356_5_v_6_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00387
Perturb_7083_KO_Jmjd4_SRP393926	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.10847
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15112
KCNG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58748
Perturb_13197_KO_HDAC3_ERP127280	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.20478
dh14	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78109
SW403	CCLE Cell Line Gene CNV Profiles	1.0	1.42622
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38169
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5378
SLC35F5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29728
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50624
mRNA_T_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40234
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SW684	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46643
GTEX-XPT6-2126-SM-4B66P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914777
Fungal infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21334
Sarcoma_SARC_TCGA-K1-A42X-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0395
substantia nigra, pars compacta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.941769
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33842
Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
Immunodeficiency 51	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
NHBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10091
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.956089
BRD-K11506071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12556
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074078
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18039
Mating projection tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.993
Sarcoma_SARC_TCGA-WK-A8XY-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10114496-mmc3.xlsx-DAXX_WT_vs_SIM_vs_control-Unnamed_13_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.02344
Perturb_6836_KO_METTL3_SRP193002	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.05125
TE5	CCLE Cell Line Gene CNV Profiles	1.0	1.69961
BACH1	ENCODE Transcription Factor Targets	1.0	null
LN319	Achilles Cell Line Gene Essentiality Profiles	1.0	1.51955
Submedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2575
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57476199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38973
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0242
MAZ	ENCODE Transcription Factor Targets	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.63294
GSE86507,GSE86509_3_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03224
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894402
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17338_KO_Mageb4_SRP259999	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.75475
ABCG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39236
LIVF001-002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25606
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTIP_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Opportunistic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5264
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
COMMD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25444
Microtubule plus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.815
Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62564
Cerebrovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62229
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32465
BRD-K45612428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70199
RB_Deficiency_GDS2757_644_mouse_Embryonic livers (day 12.5)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
USP6NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31602
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16615
Finding Of Mean Corpuscular Hemoglobin	DisGeNET Gene-Phenotype Associations	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.746
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.92488
TP53INP2_OE_GDS5054_276_mouse_SKM-Tg - Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.857716
GSE173169,GSE173170_0_v_1_epc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30355
monobenzone-3054	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dorsal striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.358
regulation of G protein-coupled receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
mantle zone of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00073
PANC1	BioGPS Cell Line Gene Expression Profiles	1.0	1.19523
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912152
GSE120336_1_v_2_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DMWD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50404
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.858358
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.234302
GTEX-XYKS-2526-SM-4BOPX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825176
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00481
RPMI7951	DepMap CRISPR Gene Dependency	1.0	2.36526
RHBDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50831
Sendai virus infection_Tracheal epithelium_GSE10211	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.64012
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.269867
TBRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5025
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19066553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0067
SNU886	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58568
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FAM241B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33715
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IA-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of hydrolase activity	GO Biological Process Annotations 2015	1.0	null
FKBP5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6285
GSE166004_5_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LARP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94568
SP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07507
Type 1 diabetes mellitus_pancreatic islet_GSE2254	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.74645
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925026
ZNF654	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16625
ABHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2788
BRD-K79347939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36128
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0428
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
PIK3CD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24736
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.960289
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.135942
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041479
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11355
Cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.997
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5664
PRDM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39232
A_CA_04_2009_4dayMOI-10^6_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.54334
Perturb_7080_KO_Hif1a_SRP300902	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.74415
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.967745
BRD-K85977570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05446
GTEX-S32W-1226-SM-4AD67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01213
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20019
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840283
GTPBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07183
Retinal rod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.578
Horizontal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.521
pregnenolone-4218	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K33539506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35286
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26176
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18786
Lung adenocarcinoma_LUAD_TCGA-55-8090-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5305_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP101434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.18654
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54348
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01343
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.90839
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041535
GTEX-XV7Q-0526-SM-4BRWR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906339
PNKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53877
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03538
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCAPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38134
GTEX-XOTO-0326-SM-4B66K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14769
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1497
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24385
POU6F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18139
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K00526921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25516
BV173 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
Leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.468
Peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.974
SIRT1_KO_GDS4895_410_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40643
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07414059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5282
Jansen's metaphyseal chondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
POLR2H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27915
ACTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78616
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01395
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01365
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13978_OE_RNU11_SRP178463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.48373
DUSP26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56904
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843818
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971853
terguride-3096	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.360324
EP300_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223008_0_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
Vermal regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03161
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41188
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2626
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.825731
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1857
Perturb_4782_KD_Trim24/Trp53_ERP019861	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.45735
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FUT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66544
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925586
SRRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68092
RMND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51445
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20905
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.439
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067256
POP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18524
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42744
cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.06144
TMEM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19596
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tonsil	HPA Tissue Gene Expression Profiles	-1.0	-0.864582
BRD-K38688128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22414
Anterior cingulate area, ventral part, 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70562
BRD-K21660570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06147
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
Synaptic ribbon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.669
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.08637
PMVK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92211
HS578T	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.908902
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922596
COR-L279	GDSC Cell Line Gene Expression Profiles	1.0	2.18087
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.43803
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02546
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intercellular bridge	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
abnormal eye electrophysiology	MPO Gene-Phenotype Associations	1.0	null
Lobules IV-V, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32603
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCYT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38653
HMV-II	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80541
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K12226398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13217
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17539
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39055
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.670064
BRD-A25883214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20434
GSE205070_1_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
ARMCX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59088
GTEX-RWS6-1326-SM-47JXB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66369
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.841747
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15815
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BACH1_02_188	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.58496
FGF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02616
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.975984
BRD-K15485967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85113
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BECKER	DepMap CRISPR Gene Dependency	1.0	2.10098
nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.152987
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.66064
INF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22436
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836741
VPS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98919
cone cell pedicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.692078
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.07917
BRD-K73475697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37515
positive regulation of gtpase activity	GO Biological Process Annotations 2015	1.0	null
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069467
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00829
MIS12/MIND type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MV411	Achilles Cell Line Gene Essentiality Profiles	1.0	1.13631
ERAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14922
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Calcium Regulation in the Cardiac Cell(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42857
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.9147
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ESR1-20056654-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE131903_0_v_2_abca12_human	RummaGEO Gene Perturbation Signatures	1.0	null
hereditary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.17335
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88589
Perturb_3351_KO_Tsc2_SRP227934	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.3723
IER5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73072
JURKAT	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48756
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2981398__F1	PFOCR Pathway Figure Associations 2024	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.92331
PUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60386
PQBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39178
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Aspergillosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.316588
USF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74356
NCIH226	DepMap CRISPR Gene Dependency	1.0	2.97428
SNRPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56577
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858114
GTEX-UPIC-0626-SM-4IHK2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82759
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43651
BRD-K12015168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12356
FBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62591
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.16555
EPB41L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97883
membrane part	GO Cellular Component Annotations 2015	1.0	null
Perturb_17281_KO_Gja1_SRP247546	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.35227
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z4-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEKHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61111
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842674
BT474	Achilles Cell Line Gene Essentiality Profiles	1.0	1.63817
hsa-miR-296-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Perturb_17210_KD_JUN_SRP188712	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.8925
RSAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56885
Cerebellar cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2323
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53679
CLDN19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29956
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31202
BRD-K85456301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12501
DARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59513
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
MAP3K1_knockout_245_GSE39240	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.31264
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061603
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16467
GSE211744_8_v_5_gdf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90806964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64153
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MOB1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90009
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HS729	DepMap CRISPR Gene Dependency	1.0	2.89098
MRGPRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47895
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.836497
MYOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98166
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17742
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11405_KD_RB1_SRP099582	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.0043
RASA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81222
BRD-K41025232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10531
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.185426
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-484	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2066	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51598
H3K27me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mpk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
MON1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24841
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.297291
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.2014
IFRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9965
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79504
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1517
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal peduncular cortex, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08553
presynaptic active zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.464397
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Septin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5505
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893817
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.563
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.51545
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43624
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
vero cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268828
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
697	DepMap CRISPR Gene Dependency	1.0	2.53184
NCIH727	CCLE Cell Line Gene CNV Profiles	1.0	1.53824
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-Overlap-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83409
nonmotile primary cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.209858
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Reactome Pathways 2024	1.0	null
GTEX-Q734-1026-SM-48U16	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831853
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.4952
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942614
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828206
GAP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81913
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.998132
INO80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02775
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.0915
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841517
GSE166004_7_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
INO80C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44033
BRD-K22435870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05814
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900975
G protein-coupled receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
18537972-TableS4	GeneSigDB Published Gene Signatures	1.0	null
HTRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64328
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34298
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.82356
Endosperm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.926
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
Outer plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.856
Perturb_3389_KO_Tcf7_SRP217200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.36646
PTSD - Post-traumatic stress disorder_Peripheral blood mononuclear cell_GSE860	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.65179
peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08236
ZR7530	CCLE Cell Line Gene Expression Profiles	1.0	2.65491
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77537
UQCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.401
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.083769
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13403
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
OR2A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19321
BE2-M17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882126
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DY-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
DIMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88683
icSARS CoV_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.50614
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870206
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31475
stomach_3a	HPA Tissue Sample Gene Expression Profiles	1.0	0.878121
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.97373
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24475
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RORB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81535
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33507
macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.238752
ELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.76532
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978776
NSC-625987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34442
PMC5522997__F9	PFOCR Pathway Figure Associations 2024	1.0	null
intermediate stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11205
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17851
GSE179775,GSE198264_0_v_2_ctcf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31332
Rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89731
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93903
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37545
LRRC75B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46845
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Multiple synapse bouton, contacting multiple dendrites	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.537
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.921216
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CBX2_KO_GDS4445_354_mouse_E11.5 XY embryonic gonads	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
AFDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46391
KARPAS299	CCLE Cell Line Gene CNV Profiles	1.0	2.23359
DHRS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10115
SEC61G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31311
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07412
RGMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10718
regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
sublayer 6a of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14689
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7635
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DHFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99564
BRD-K47577519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12252
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044129
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05069
Perturb_9778_KD_Gas41_SRP110498	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.65254
GNA14	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15851_KO_RbpJ_SRP165224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.40327
KMS27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55619
gonadotrophic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230656
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
Basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.886
CAPN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48688
Subapical complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
ZNF492	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43989
GTEX-SNMC-1626-SM-4DM52	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19777
Autosomal recessive spinocerebellar ataxia 20	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.6
MAP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92043
synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.118361
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
cytoplasmic side of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.00975
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34826
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Polarisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64555
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.703
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05766
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.14205
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H2BC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08968
BRD-K41172555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52035
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.841301
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073784
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLFN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41334
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47466
Olfactory receptor neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
HIRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19264
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52129
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K52197325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61422
ITGA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31226
PPME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61229
RELA_01_30	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.33198
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Xylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.952
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32922
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908969
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17321
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A4ZW-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
GPCR downstream signaling	Reactome Pathways 2014	1.0	null
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7472
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10288935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14326
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061816
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.195183
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTF2A1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25113
A704	CCLE Cell Line Gene CNV Profiles	1.0	1.61192
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67783
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
Familial adult myoclonic epilepsy 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
Perturb_17564_KO_Runx3_SRP074412	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.08456
Lung adenocarcinoma_LUAD_TCGA-55-A48Z-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00522
SMARCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80689
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08286
Bone resorption disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
Perturb_4306_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.18449
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.29821
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08414
Invasive aspergillosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	200.095
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863304
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56181
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22548
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832518
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56305
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ECC10	CCLE Cell Line Gene Expression Profiles	1.0	1.73497
ADRA2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34595
WDR18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90108
NDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18948
SLC9A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0468
ERRFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33874
Lung adenocarcinoma_LUAD_TCGA-71-6725-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.633
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	240.568
dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.644001
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25617
hsa-miR-4710	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CTSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52113
GTEX-XQ8I-0726-SM-4BOPU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00209
GABPA	ENCODE Transcription Factor Targets	1.0	null
GAK	GDSC Cell Line Gene Expression Profiles	1.0	1.48321
Intellectual developmental disorder with cardiac arrhythmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40817
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07812
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CYB5D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96507
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40474
PCI30	DepMap CRISPR Gene Dependency	1.0	2.19999
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09968
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mediodorsal nucleus of the thalamus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06018
Perturb_9696_KO_GPNMB_SRP382180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.79243
LLPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64776
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54228
CHAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84205
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18262
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21927
BRD-K48266244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65623
layer 6 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14056
Secondary motor area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42583
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.762
CALU6	DepMap CRISPR Gene Dependency	1.0	2.4396
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Signaling by GPCR	Reactome Pathways 2014	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07101
pancreatic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103183
Systemic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
16141321-Table2	GeneSigDB Published Gene Signatures	1.0	null
Signaling by GPCR	Reactome Pathways 2024	1.0	null
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25759
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Neuron to neuron synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.617
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0895
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0812
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
colorectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096553
Optic cup	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.427
NOCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07674
BRD-K30563122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10022
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	236.604
SESN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.99718
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04544
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.910065
ZNF365	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67613
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36309
Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56595246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04502
ZNF296	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59604
OCUG1	DepMap CRISPR Gene Dependency	1.0	3.32437
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
ramipril-6792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50421
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10765
Perturb_16897_KI_Htt_SRP250656	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.15029
ARF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48558
CD151	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07706
BRD-K52868251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36443
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.4993
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.367
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
RPMI-2650	GDSC Cell Line Gene Expression Profiles	1.0	2.08293
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_37_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00966
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906593
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP6V0E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02748
PRKAR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20408
BRD-K31851055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54935
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CACYBP	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R0-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4603_KO_Mst_SRP246200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.99646
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.30815
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
RNF144A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65072
BRD-K75135426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03419
BRD-K85572169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03038
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.893047
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
GBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53496
Mating projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.942
H2BC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77795
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01142
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.889458
Infralimbic area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.96737
NCI-H1688	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_17409_KO_Kat7_SRP346204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.33718
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
MARCHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38745
Subfornical organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
GTEX-XMK1-2426-SM-4B66I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31882
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
extrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.912977
Nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.525
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34508
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RHBDL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89598
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35549
sublayer 6b of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3994
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A67254212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86811
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.70708
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T84	DepMap CRISPR Gene Dependency	1.0	4.2935
Hyphal tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.319
STARD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61864
BRD-K97938633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10252
stomach	HPA Tissue Protein Expression Profiles	1.0	1.20661
LIMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63797
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0387
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
YD8	DepMap CRISPR Gene Dependency	1.0	2.16633
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07881
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Pain	CTD Gene-Disease Associations	1.0	1.10665
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.62552
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042347
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00881
Pancreatic acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.85
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.80426
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02155
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75059
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.92331
ZNF384	ENCODE Transcription Factor Targets	1.0	null
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.815
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211955_1_v_0_jmjd4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7576-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10841
CRCGN016_MCF10A.TP53.M_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49293
NUDT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27309
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QK-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.074
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	2.61431
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26775
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64463
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889086
CCDC28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02859
Mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
BRD-A73635700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64428
Dorsal nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01884
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sensory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.071
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8325
extrinsic component of cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.06144
Photoreceptor ribbon synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
olivary pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22015
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31344
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-A46V-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91297952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00345
RASL11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06532
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.798
GSE179974_3_v_2_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89956
RHOQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70372
UACC812	CCLE Cell Line Gene Expression Profiles	1.0	3.40791
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3135b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57082
basomedial amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10868
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.87987
GSE137818_5_v_0_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TYSND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63663
BRD-K24284160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03986
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.963572
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
KARPAS299	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53183
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17443
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08283
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37969
H3K27me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.828791
JAGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69426
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02326
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8660-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13147
HAPLN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54551
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9788
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47241
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02325
ADRB2	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.96346
LBHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06122
Retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10021
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16791
KRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40218
GSE100217_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2404
KLF4-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-2026-SM-3P61N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828696
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71979
MT-ND4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28111
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15436
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TSA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
BRD-K47854067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20537
SLC39A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18174
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83924
hsa-miR-4804-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
JARID2-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K00542622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12941
Orbital area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10069
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Corpus striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.899
BRD-K95435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31547
CENPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16549
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900419
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
neuron projection	GO Cellular Component Annotations 2023	1.0	null
JP-4-043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07656
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21031
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
EPS15L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85218
Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27021
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cryptococcosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
fungal-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.757
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12552
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RC-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13629
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Drug dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09588
Retrosplenial area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22711
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.52793
GSE109285_5_v_4_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4939
BRD-K49866472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06011
SCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93853
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28487
MXI1	ENCODE Transcription Factor Targets	1.0	null
BRD-K06784595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08824
HL60	Achilles Cell Line Gene Essentiality Profiles	1.0	2.12013
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.195183
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.6553
HLTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24041
CAL148	CCLE Cell Line Gene CNV Profiles	1.0	1.43985
mature ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.136385
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF709	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50795
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AKAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98222
Perturb_13038_KO_Brca1_SRP170547	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.16425
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23207
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48242
hep-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.265381
GNA15	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DNAJB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21101
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.882007
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51233
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BL7536 (EEA1)	NURSA Protein Complexes	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.84
COLO684	CCLE Cell Line Gene Expression Profiles	1.0	2.18584
GTPase regulator activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896469
RARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41922
RBBP5	ENCODE Transcription Factor Targets	1.0	null
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PGAM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7623
BRD-K23342427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14957
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-2526-SM-4E3HY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866587
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
PRSS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2806
BRD-K97330035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47217
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888468
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09213
MRPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40652
BRD-K92202681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42277
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_12_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VCAP	CCLE Cell Line Gene Expression Profiles	1.0	1.57104
BRD-K39438085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11299
Perturb_7921_OE_HLAG_SRP386250	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TRIM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14136
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11871
COLO-678	GDSC Cell Line Gene Expression Profiles	1.0	1.66891
reported	GeneRIF Biological Term Annotations	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045824
GSE100217_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3064-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
EFO21	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18389
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.52737
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
Prelimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17808
NOXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89008
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PRR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4966
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33418
ZR-75-30	GDSC Cell Line Gene Expression Profiles	1.0	1.56568
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.2901
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982271
Perturb_8687_KD_FAT1_SRP358313	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.44592
GTEX-WY7C-2626-SM-3NB2P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01206
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912405
Sarcoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.196
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Actomyosin contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.938
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.7421
PCSK1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92717
TOE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45118
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
enzyme activator activity	GO Molecular Function Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK2AP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69369
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
NFIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16389
TNFRSF12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19199
Stress fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.394
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.7742
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.98953
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytoskeleton of presynaptic active zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.391
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82578220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01127
TP53INP2_OE_GDS5054_385_mouse_Muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1337
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06592
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.978809
BRD-K56520977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0943
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POTEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60589
ZNF84	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56812
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054746
LBH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77006
GTEX-TKQ1-1326-SM-4DXU7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06888
H103	DepMap CRISPR Gene Dependency	1.0	2.93754
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0878
Paraventricular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42083
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40507
GATA1-19941827-MEL-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Ribbon synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.6
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.71523
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03759
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853878
SNTA1	Pathway Commons Protein-Protein Interactions	1.0	null
FSCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83757
BRD-K08146255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27141
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
PNRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09139
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TT	GDSC Cell Line Gene Expression Profiles	1.0	2.12193
496100319_HIP_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24041
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48453
Rod photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.632
Superior cervical ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83556
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94301203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10927
Lobule III	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73675
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91639
superficial stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1705
MJ	DepMap CRISPR Gene Dependency	1.0	3.28237
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.4863
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971812
Parallel fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
Perturb_12078_KO_Ezh1_SRP060232	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.34974
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08411
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30452
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cotyledon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
CD55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31747
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE147056_3_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96435
BRD-A29371732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1099
galphaoa	GeneRIF Biological Term Annotations	1.0	null
Perturb_8424_KO_DGAT2_ERP114849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
THUMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46398
Sarcoma_SARC_TCGA-K1-A42X-02A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31393518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34858
Protein folding	Reactome Pathways 2024	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Root apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5769
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01918
reuniens nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1018
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20085
BRD-K86192746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81811
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28452
TRIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26298
DU4475	CCLE Cell Line Gene Expression Profiles	1.0	1.80074
BRD-K67104687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18172
ac2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
rectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.082566
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.138279
H3K27me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21031
GTEX-NPJ8-1326-SM-3LK6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32157
TPD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09988
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00073
Sclera	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
CTTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33109
Barrington's nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47104
CAKI2	CCLE Cell Line Gene CNV Profiles	1.0	1.5127
Ankylosing Spondylitis	DisGeNET Gene-Disease Associations	1.0	null
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	219.804
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4746
AFG3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76821
BRD-K68470956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26248
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14357
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855014
PCDHB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55891
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.106446
ABHD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40333
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.00727
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.066954
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09744
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal eye physiology	MPO Gene-Phenotype Associations	1.0	null
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-1.51545
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874187
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.53334
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STRN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87622
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	1.87052
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.417685
Carcinoma, Squamous Cell	HuGE Navigator Gene-Phenotype Associations	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
BRD-K96164740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23118
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94999
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03311
gallbladder	HPA Tissue Protein Expression Profiles	1.0	2.2243
BRD-K39379715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42124
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50924
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.60172
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877621
HDDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84623
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HD-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RERFLCSQ1	CCLE Cell Line Gene Expression Profiles	1.0	1.48014
SLC41A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33273
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	0.921373
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	328.741
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28939
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_KLF4_19030024	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.957331
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78847404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17003
HCC1897	CCLE Cell Line Gene Expression Profiles	1.0	1.70904
UACC-812	GDSC Cell Line Gene Expression Profiles	1.0	1.75645
GSE211286_4_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3767_KD_lincDUSP_SRP111736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.78608
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057496
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09308
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11846
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	187.97
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86328
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03888
TSC1_Deficiency_GDS4572_346_mouse_Naive CD4  T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cytoplasmic side of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
NKX6-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01011
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884137
KAT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90626
GTEX-WOFM-1626-SM-3MJFX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06218
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.306672
Perturb_13643_KD_Tasor_SRP126388	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.22731
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53004
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04684
NDUFA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89741
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.882007
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46759
RBM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18577
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06678
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29184
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.57945
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55483
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, nose, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17964
emx2_20962046_e10dot5_urogenital_epithelium_lof_mouse_gpl1261_gds3173	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.853562
GNL3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60619
H2AC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07428
Pons	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60721
LU-135	GDSC Cell Line Gene Expression Profiles	1.0	1.45704
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963186
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31551
BRD-K18316646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48083
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131798,GSE131804_5_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13944
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55237592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97085
GOLIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5978
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NDRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8666
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04556
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055239
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3131
BRD-K51654114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25823
MED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58361
recombinant	GeneRIF Biological Term Annotations	1.0	null
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.58431
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08261
ZFHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59123
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0468
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45318
TSC1_Deficiency_GDS4572_347_mouse_Naive CD8 T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K69585439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08192
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36837
Dendritic spine neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.825
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25394
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.829418
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92896
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61837
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01001
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28029
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968139
NIHOVCAR3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.50982
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.94563
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	221.769
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inner nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.349
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
orbital frontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.88013
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.08091
colorectal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.10755
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1101
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Medium spiny neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.169
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48299
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34761198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07058
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.863334
Perturb_3358_KO_Xbp1_SRP157113	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.05589
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10977
LIN7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22085
dendrite terminus	GO Cellular Component Annotations 2015	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11952327-media-1.pdf-26-NPAS1_NPAS1	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
TRIM61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52862
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Xylanosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.606
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.392775
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.24453
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.93698
BRD-K57724549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56217
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
exocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.1856
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
Np	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
inner SZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16416
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.913693
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15723
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.05193
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1748
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72471
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4319
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67623
GTEX-NPJ8-1726-SM-2YUNB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974069
BRD-K55518911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08126
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33324
LMTK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.55859
pancreatic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.163427
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16265
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.850005
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18402
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54903703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11671
Mesothelioma_MESO_TCGA-MQ-A4LJ-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995671
FBXO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49506
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.827356
dystrophin-associated glycoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.004
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63276
TMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2984
ROCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28775
DDX60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98238
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.849592
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14505_KO_Tgfb3_SRP020224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.11228
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.056754
GNAI2	Pathway Commons Protein-Protein Interactions	1.0	null
Nucleus of reunions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42752
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16471
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8483
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.248
GSE129241_3_v_6_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP3K20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34614
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847923
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EA-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SENP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65743
Pinealocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
Varicosity	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.673
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96616
GTEx SmallIntestine 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	5.41493
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40514
Perturb_13646_OE_miR23/miR24/miR27_SRP067253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.847923
GSE157904_0_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63988
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARHGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3577
GTEX-XYKS-1726-SM-4E3IO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964986
Capitate projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.568
HOXB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76823
EWS-ERG-20517297-CADO-ES1-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.726694
Retinoschisis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00058
PURB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30323
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48557872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25485
HPBALL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45773
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.93855
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATCAY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25933
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30471
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLFN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98406
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH441	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18937
Septin collar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.145
BRD-K52261313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15355
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24359
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.998576
neuron projection terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.138642
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19331
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.8654
QGP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTF3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27904
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.888453
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34586
MFH-ino	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54145
SCRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52449
BRD-K16279128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32879
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04277
Bradyopsia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.343
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEx Thyroid 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	6.26762
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01943
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26402
Orbital area, medial part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80419
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885005
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15538
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0375
GTEX-OHPN-2926-SM-3LK65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951559
LRCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55599
Field CA3, stratum lucidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11296
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.638
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.1435
RFXANK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37208
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIKESHI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24025
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
presynaptic cytoskeletal matrix assembled at active zones	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.491348
GTEX-X3Y1-2426-SM-3P5Z7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07963