association dataset threshold value standardized value IMPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71657 r8 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12709 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NANOG ENCODE Transcription Factor Targets 1.0 null PHLDA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59752 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRX-20693478-ADULT_RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.48872 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TE-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05563 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A113-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01588 E2A MotifMap Predicted Transcription Factor Targets 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.64994 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12466 GSE225901_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null MOSPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08974 UIMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63409 MLXIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41687 TMEM89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94709 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null GSE135514_2_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.827426 HCC1187 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9942993-pone.0281645.s002.xlsx-AR-as_adaptive_as_lost-ENSEMBL_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Aortic root TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.795 Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.56572 KLF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 97.4594 superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24271 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null limb grasping IMPC Knockout Mouse Phenotypes 1.0 null AMO1 CCLE Cell Line Gene CNV Profiles 1.0 1.5251 GSE124471,GSE124488_1_v_0_lats1_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsal part of m1A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27702 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00861 Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.132 WSCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88651 NKX3-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25469 GAL3ST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08425 endometriosis GWASdb SNP-Disease Associations 1.0 0.634147 GSE88819_1_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100310_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.14001 ZFHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39391 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GPR107 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25223 ADGRE5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74709 preweaning lethality, incomplete penetrance IMPC Knockout Mouse Phenotypes 1.0 null SMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1784 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2 Rummagene Transcription Factor Associations 2026 1.0 null USP2_KO_GSE43517_20_mouse_kidney GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MSS51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72621 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null presubiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01412 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.58528 MMACHC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42631 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SLC66A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18322 anteroventral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49057 496100305_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.28118 PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Entorhinal area, medial part, dorsal zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62713 H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GRIN3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8276 GSE190316,GSE190324_1_v_11_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null APBA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80241 RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.948037 LTBR_INHIBITION - 35 Day_GDS2005_732_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SCML1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50818 HOS COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 HCC202 DepMap CRISPR Gene Dependency 1.0 2.14746 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16844 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPATA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96548 HAUS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48106 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_14788_OE_Slit2_SRP267596 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.3553 BTBD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83057 SDR42E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28626 SNAP47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25281 mantle zone of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40156 Perturb_2233_KO_Irf8_SRP270893 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.81689 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.41326 MAN2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49433 LD-69-ZV56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221492 TUNAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52221 r7 part of the nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47062 ZNF735 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03014 KLRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9212 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LYSMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07034 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AKT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73399 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40985 ZDHHC23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32207 SW1271 CCLE Cell Line Gene CNV Profiles -1.0 -1.88091 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.74169 ZNF813 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41368 NMCG1 CCLE Cell Line Gene Expression Profiles -1.0 -1.53866 KLK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83768 DMS454 CCLE Cell Line Gene Expression Profiles 1.0 1.63946 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cortical amygdalar area, posterior part, medial zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39082 VZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.93262 Anteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49457 BEND5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60247 CEP170B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04892 UQCRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13407 SMURF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79293 H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22358 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SOX10_KO_GDS3480_257_rat_Schwannoma cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF611 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27981 TRA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34052 RWDD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33902 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CDKN1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73634 LEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35925 Usp22_DEPLETION_GDS4973_284_mouse_E14 embryonic stem cells (ESCs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null AKT2_knockdown_44_GSE12291 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.0795 GGA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13346 NEK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93589 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 53.7224 CXCL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90531 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4876-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.4231 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.948714 H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88773 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.31041 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.979444 PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.77837 GSE210101,GSE210114_4_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null CCDC85C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2567 NFIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63357 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of the VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85185 GSE122711_1_v_3_mpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.290078 inner SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.93993 DCTN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72191 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SMCR8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94769 RPS20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51368 ZBTB46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11342 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_15767_OE_Msi1_SRP218930 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.07832 Perturb_11575_OE_YAP_SRP273175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.85158 TBC1D10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92403 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AA-23-FM46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.42299 PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41344 inner SZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.908926 CAL120 CCLE Cell Line Gene CNV Profiles -1.0 -1.59336 SYNGR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42307 YMB1 CCLE Cell Line Gene CNV Profiles 1.0 1.54333 PDCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.0363 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 r1 part of vestibulocerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14388 GSE130383_2_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100586_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.105 spleen HPA Tissue Protein Expression Profiles -1.0 -1.74482 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU503 DepMap CRISPR Gene Dependency 1.0 2.28811 SHSY5Y DepMap CRISPR Gene Dependency 1.0 2.54939 LRP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90208 STX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84735 Ascites tumor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.861 KDM5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88617 H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null NRL_Deficiency_GDS1693_238_mouse_Photoreceptors cells of retinas at P10 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00081 POLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31819 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WASHC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53296 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP53 ChEA Transcription Factor Targets 1.0 null Nucleus of the solitary tract, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06803 Perturb_14919_KO_Polr2a_SRP181107 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.4497 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RTN4RL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36192 Wt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 89.2345 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34087 KELLY CCLE Cell Line Gene Expression Profiles 1.0 1.771 dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25903 ATP2A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5378 RORB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81535 salivary gland GTEx Tissue Gene Expression Profiles -1.0 -2.10011 PRKACB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76862 COLO668 CCLE Cell Line Gene Expression Profiles 1.0 2.13763 VZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.943787 Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.50942 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.829 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Subiculum, ventral part, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0382 Sarcoma_SARC_TCGA-DX-A1KW-01A-22R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31248 STC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49283 TIA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42744 LN443 CCLE Cell Line Gene CNV Profiles -1.0 -1.4646 MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3513 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50903 NR3C1 ENCODE Transcription Factor Targets 1.0 null NDUFS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09986 ISHIKAWAHERAKLIO02ER CCLE Cell Line Gene Expression Profiles -1.0 -1.82726 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23193 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35644 ZFP82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77802 intermediate stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14634 A253 DepMap CRISPR Gene Dependency 1.0 2.55676 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFATC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42591 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A-VN-1203-2004(H5N1)_Day4-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.04488 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00208 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J1-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBC1D23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12959 496100430_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05394 ZNF880 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38289 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.854662 GSE180185_4_v_1_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null NCIH226 DepMap CRISPR Gene Dependency 1.0 4.37306 IKBKB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.24152 Median preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15085 KIF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.234 APOBEC3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37142 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UACC812 CCLE Cell Line Gene CNV Profiles 1.0 2.63464 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3663-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.860871 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null abnormality of the genital system GWASdb SNP-Phenotype Associations 1.0 0.091528 TP53-23651856-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ATRIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58331 Subiculum, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32861 SOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74504 GABBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50826 ODAD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86476 Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10858 H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ENDOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5815 DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.975535 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLB1L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94682 RAB22A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07979 VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28465 TRMT10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84624 GSE214382,GSE214383_4_v_2_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UNCX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36594 H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27778 N4BP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29388 H3K27me3_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZDHHC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11158 Perturb_15117_KD_Rtn4_SRP278924 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.29268 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.87851 Perturb_6568_KO_Ywhaz_SRP056013 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.35007 placenta HPA Tissue Protein Expression Profiles 1.0 1.17801 USP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64226 SOWAHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42698 CHD2 ENCODE Transcription Factor Targets 1.0 null HCC1187 DepMap CRISPR Gene Dependency 1.0 6.07569 PLEKHM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52133 inner SZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.937076 496100471_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06958 p1 portion of the paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56345 TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 133.316 PNCK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68804 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58545 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NECTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15783 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Specific developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.131 lymph node HPA Tissue Protein Expression Profiles -1.0 -1.74482 TMEM106B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7075 KRBOX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66302 ZEB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4742 Allergic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11283 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.68031 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.16644 Perturb_13608_KD_Rbfox2_SRP136943 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.0191 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.16187 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.99242 GSE157960_0_v_1_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null BNIP3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42733 Primary somatosensory area, barrel field, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08183 BCPAP CCLE Cell Line Gene CNV Profiles -1.0 -2.14433 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-F2-A44H-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.851838 Posterior amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08854 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CYREN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89022 GSE65617_5_v_3_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null ABCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95509 WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06955 GABRA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5047 ALG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64845 PRRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82013 Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZR751 CCLE Cell Line Gene Expression Profiles 1.0 1.40739 GSE168587,GSE168752_3_v_1_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null PEX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77889 PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53 Rummagene Transcription Factor Associations 2026 1.0 null PTGER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70273 BCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60438 LGALS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47207 NCIH1105 CCLE Cell Line Gene Expression Profiles 1.0 1.38184 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZMAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05073 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HCC56 CCLE Cell Line Gene Expression Profiles 1.0 1.60619 ABL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20406 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.951091 FIGNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94237 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13847 Lung squamous cell carcinoma_LUSC_TCGA-43-7657-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.993926 TSKU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03604 PPIF_KO_GSE23028_45_mouse_heart (8 wk) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CREB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25618 Asthma GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.5 TNKS1BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67954 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of p2ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14634 POLR3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7805 Heart disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.714 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MSI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45606 Muscle myosin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.666 NOXO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89008 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16853 TIMM10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03412 hsa-miR-150 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain GTEx Tissue Gene Expression Profiles 1.0 0.967664 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2047 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IFT20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53266 voltage-gated potassium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.973 SIMA CCLE Cell Line Gene Expression Profiles 1.0 1.55835 HNF4 MotifMap Predicted Transcription Factor Targets 1.0 null PLEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44204 HCC1937 CCLE Cell Line Gene CNV Profiles -1.0 -2.42462 posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55201 Brain Lower Grade Glioma_LGG_TCGA-R8-A6MO-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.0699 SNRPB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25759 MEAK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67826 Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null Sperm fibrous sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.828 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intestinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.829 PBDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7422 H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TGIF2LX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0459 dorsal part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49128 HACD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83425 ADI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95899 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877555 Lung squamous cell carcinoma_LUSC_TCGA-22-4605-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NPEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53028 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.11762 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47511 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AGFG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37219 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00615 DSTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60181 GNPDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66227 H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AP1S2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95469 A2058 CCLE Cell Line Gene Expression Profiles -1.0 -2.49743 TBX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2704 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_S7A-GENE_LIST_UPLOADED_TO_ENRICHR_MLX_TESTES_855_GENES_MLX Rummagene Transcription Factor Associations 2026 1.0 null emx2_20962046_e10dot5_urogenital_epithelium_lof_mouse_gpl1261_gds3173 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.503794 AFF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46405 superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05439 APOA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81109 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.829 SOX2-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null TMEM47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14844 PPP6R3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28427 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71168 MAZ ENCODE Transcription Factor Targets 1.0 null CCM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16061 Lung adenocarcinoma_LUAD_TCGA-50-7109-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null SLC18B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78651 JcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.49216 SOX2 ChEA Transcription Factor Targets 1.0 null GSE149035_2_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PPM1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21869 RGS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71152 COL4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48606 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01898 ZBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94666 PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99301 SLC1A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10554 CAOV4 CCLE Cell Line Gene CNV Profiles -1.0 -1.4053 NR1D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08645 Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GOLGA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82395 NKX2-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12046 SELENOT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72902 PTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87933 Liver TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Cortical amygdalar area, posterior part, medial zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.359 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8303 NCIH929 CCLE Cell Line Gene CNV Profiles 1.0 1.49864 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Entorhinal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62713 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.0267 all GWASdb SNP-Phenotype Associations 1.0 0.028401 Intracellular cyclic nucleotide activated cation channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.695 H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21441 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null smarcc2_00000000_e12dot5_embryonic_cortex_lof_mouse_gpl6887_gse45629 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.301211 USP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69663 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_7_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null rectum HPA Tissue Protein Expression Profiles 1.0 1.17801 RAD23A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63294 H3K27me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54462 CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50598 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09307 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE191105_0_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4763_KO_DLG2_SRP315088 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BORCS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25803 JHU022 DepMap CRISPR Gene Dependency 1.0 4.83896 PcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.27654 Major island of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11865 GSE216043_11_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63193 TLCD3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18018 TEAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92766 Amylin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.268 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null SP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01998 Brain Lower Grade Glioma_LGG_TCGA-R8-A6ML-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PANC1005 DepMap CRISPR Gene Dependency 1.0 2.27053 COQ9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43007 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28463 female reproductive system disease GWASdb SNP-Disease Associations 1.0 0.235928 BT483 CCLE Cell Line Gene Expression Profiles 1.0 1.89571 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.910805 RLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55566 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.962521 GNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51573 Sarcoma_SARC_TCGA-MB-A5YA-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterodorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829058 PRMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12756 Perturb_14680_KO_P2Y14_SRP044222 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.35651 superficial stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49594 Perturb_18004_KO_Lrp1_SRP220333 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.96241 U2AF1L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06644 ESRRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.52486 ZNF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54858 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66306 NSUN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60705 LLPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64776 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HBQ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09713 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17012 Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7951 nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51981 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.936771 Perturb_4713_KO_Hnrnpu_SRP331236 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.57941 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6474 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.4607 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.917052 GSE191105_2_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PN-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29063 H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04543 posteromedial cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40156 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null CIART CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7545 SLC4A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03133 NACAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85549 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44035 TRERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.673 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.131 TIPARP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45461 Lung adenocarcinoma_LUAD_TCGA-49-6745-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.940226 SSU72 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8657 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organism form TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D2-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null S100A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42539 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.27464 GSE236280_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Mitral cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.541 Nose disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 RAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64315 H1-8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71125 septum (resp epith) BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 HELZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55233 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DCANP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13289 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.993558 RASL10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67902 TENT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32226 Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral posterior parvicellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40727 COLO680N DepMap CRISPR Gene Dependency 1.0 2.33399 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0202 H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RDH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59325 Perturb_4366_KO_Qki_SRP153187 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.56381 MED14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73641 TNPO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71068 TPCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99667 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Secondary motor area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54036 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KIF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27838 Rectum adenocarcinoma_READ_TCGA-CI-6622-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24689 STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01079 Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CALB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42463 TMEM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26186 SPIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33099 ATP6AP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9347 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2939-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0165 ZNF723 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55487 CAOV3 DepMap CRISPR Gene Dependency 1.0 5.74812 THNSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32999 Nuclear proteasome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.823 ZNF771 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8984 SERINC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59355 UBE4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6429 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SKNFI CCLE Cell Line Gene Expression Profiles 1.0 2.92799 NCIH526 CCLE Cell Line Gene CNV Profiles 1.0 1.36513 Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RWDD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92551 VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35185 Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SEMA4G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.67853 HMY1 DepMap CRISPR Gene Dependency 1.0 2.09951 CREB MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FF-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4375 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.33224 143B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.084 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06815 NB1 CCLE Cell Line Gene Expression Profiles 1.0 2.56022 Retrohippocampal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15085 ZFYVE26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.452 GYPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1876 H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45414 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.868511 Brain Lower Grade Glioma_LGG_TCGA-TM-A84M-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null HUPT4 CCLE Cell Line Gene CNV Profiles -1.0 -2.00169 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 99.2102 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine carcinosarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 CFP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69619 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormal internal genitalia GWASdb SNP-Phenotype Associations 1.0 0.150545 MATH1 MotifMap Predicted Transcription Factor Targets 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.871862 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91263 SAMHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9993 JHUEM2 CCLE Cell Line Gene Expression Profiles -1.0 -2.06686 BB30HNC DepMap CRISPR Gene Dependency 1.0 7.76249 REST ChEA Transcription Factor Targets 1.0 null GCNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01919 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26023 PITX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81416 FANCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32228 Perturb_9685_KD_SMARCB1_SRP279089 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.76541 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52683 doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-5784-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37721 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.01297 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02534 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HMGA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98031 Perturb_15608_KO_Dnmt1_SRP247926 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.56599 GSE140441_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Amylin receptor complex 1 COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.357 Cortical amygdalar area, posterior part, lateral zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.39489 Perturb_5089_KO_Sall4/Sall1_ERP014607 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.77758 GSE180185_9_v_5_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null CDC42SE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33897 BHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27678 LIF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73473 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null c-Ets-1 MotifMap Predicted Transcription Factor Targets 1.0 null PRPF38B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62085 DUSP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57228 dorsal terminal nucleus of the accessory optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08433 primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.87732 olivary pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18303 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of AStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03203 STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null HHIPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85888 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7056-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE136627_2_v_1_hdac4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE198683_1_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.063661 Brain Lower Grade Glioma_LGG_TCGA-S9-A7QZ-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DUSP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78949 NCI-H345 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 PCGF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99894 periventricular mantle of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08854 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JcP contribution to LTL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8905 intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97299 MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03854 primary somatosensory cortex (area S1, areas 3,1,2)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.844948 Perturb_9529_KO_Clock_SRP252642 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.07355 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Medial amygdalar nucleus, posterodorsal part, sublayer c Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85185 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3513 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.831144 Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Gastrointestinal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.829 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AAGAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77462 QA-07-KC40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.257901 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HTR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68669 PPM1K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10884 TBC1D24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55832 CAPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68257 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PPP5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29339 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.849024 TRIM41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89181 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KMS20 CCLE Cell Line Gene CNV Profiles 1.0 1.68483 YKT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61958 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.84876 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 ACSM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75336 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 1 of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20396 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04652 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTARC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78623 A-Vietnam-1203-2004(H5N1)_2day-wtC57BL-6J_None_GSE40792 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.10832 NCIH2227 CCLE Cell Line Gene Expression Profiles 1.0 1.70845 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16433 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 1.66734 GSE183271_4_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Synaptic vesicle, readily releasable pool COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.745 DMTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97516 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64253 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SFRP5_KO_GDS4988_27_mouse_gonadal white adipose tissue HFD GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ovary HPA Tissue Protein Expression Profiles -1.0 -1.74482 GSE245778_1_v_0_runx1_human RummaGEO Gene Perturbation Signatures -1.0 null EMX2_Deficiency_GDS3173_607_mouse_Embryonic urogenital epithelium - day 10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.7941 FNDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83312 ZSCAN25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17473 NCIH1623 CCLE Cell Line Gene CNV Profiles 1.0 1.97465 subiculum, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.98568 shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30585 tonsil HPA Tissue Protein Expression Profiles -1.0 -1.2208 reticular formation of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02608 VZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36334 Primary somatosensory area, lower limb, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4638 Nasal cavity disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 DCLRE1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81953 POGZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97315 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.61923 inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19236 ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.9505 Brain Lower Grade Glioma_LGG_TCGA-DU-5870-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Parasubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25447 Lung squamous cell carcinoma_LUSC_TCGA-22-5471-11A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SATB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5345 nucleus sagulum, deep part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43512 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2029 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KHM1B CCLE Cell Line Gene CNV Profiles 1.0 1.88167 H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null SKNDZ CCLE Cell Line Gene Expression Profiles 1.0 2.25278 CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26631 Declive (VI) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12547 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.38919 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null CCDC115 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20875 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56903 DU-145 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 Alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Embryonic structure TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885889 EBC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.74918 PTGR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03855 Artery disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.056 Cortical amygdalar area, posterior part, lateral zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.39489 ZNF263 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.499 NCOA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8971 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.883114 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854914 Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07233 CASP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86666 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.950343 ventral part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.1773 ABAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96371 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NR3C2-34362910-WISTARRAT-HIPPOCAMPUS ChEA Transcription Factor Targets 2022 1.0 null GSE114013,GSE114014_0_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37572 GSE102870_7_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EMB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44225 SP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07507 DCBLD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02665 H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RO-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP1R14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04314 PMC5354742__F3 PFOCR Pathway Figure Associations 2024 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RYBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83938 Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KATNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04134 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4640-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.8276 AKAP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98222 EMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62872 GSE211474,GSE212779_0_v_1_phf8_human RummaGEO Gene Perturbation Signatures -1.0 null FAM193B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34856 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.48225 DDX23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23791 PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.60038 GSE234289_4_v_0_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null UBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96804 ORMDL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99664 absent vibrissae IMPC Knockout Mouse Phenotypes 1.0 null SLC52A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49491 HOS CCLE Cell Line Gene CNV Profiles 1.0 1.62097 Myosin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.907 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.858265 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16698 DPEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54616 spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.18985 CEBPB ENCODE Transcription Factor Targets 1.0 null CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTAGE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42332 GATA3_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AFG3L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76821 SKLMS1 CCLE Cell Line Gene Expression Profiles -1.0 -1.49336 PTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62561 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6328 superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37534 GSE176093_0_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures 1.0 null DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220376 Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 5.21769 inner SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09114 GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22047 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18317 VZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10356 CNOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64595 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ATP1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96586 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.49041 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null ZNF281 ChEA Transcription Factor Targets 1.0 null TIA1_KO_GSE54418_265_mouse_midbrain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null disease GWASdb SNP-Disease Associations 1.0 0.024241 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.08727 H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Myocardial infarction DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.056 H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SCRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52449 GSE133691_2_v_0_lgr5_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CMTM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51888 PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38 Rummagene Transcription Factor Associations 2026 1.0 null ATG16L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66705 SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24198 body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03 SCC4 CCLE Cell Line Gene CNV Profiles -1.0 -1.88947 COMMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57829 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.56382 RING1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61569 GJC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3878 PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38 Rummagene Transcription Factor Associations 2026 1.0 null GSE166944_0_v_2_eif4b_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.937497 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05977 496100339_HIP_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16925 Motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.439 Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12347 bronchus HPA Tissue Protein Expression Profiles 1.0 1.17801 Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64541 ABHD16B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69046 Anterior cingulate area, dorsal part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0823 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.84678 GSE149096_4_v_3_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null rostromedial tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12347 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null QPCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41321 AFF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51668 hippocampus HPA Tissue Protein Expression Profiles -1.0 -1.03106 Perturb_16506_KD_HEPACAM2_SRP257754 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.08856 EHMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92291 caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.944309 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Inflammatory bowel disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.829 HCC2218 CCLE Cell Line Gene CNV Profiles 1.0 1.62442 Enteroendocrine cell_Small intestine_Mouse CellMarker Gene-Cell Type Associations 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE190316,GSE190324_6_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64841 SKLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.53333 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OXSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83604 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0815 periventricular stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34827 MCF7 CCLE Cell Line Gene CNV Profiles 1.0 1.3282 SP140 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46128 Brain Lower Grade Glioma_LGG_TCGA-W9-A837-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fields of Forel Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21705 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Medial amygdalar nucleus, posterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20396 SNX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56141 HELB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19827 GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null MEX3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67507 Bed nuclei of the stria terminalis, posterior division, interfascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25608 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53299 ARSI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42989 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9234 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33086 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 191.125 TIPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45584 GSE176008_7_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null LZIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39921 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.714 PRDM1 ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endothelin Pathways(Homo sapiens) WikiPathways Pathways 2014 1.0 null HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.12126 ChIP_SOX2_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03823 CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58459 SLC1A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9803 KMS11 CCLE Cell Line Gene CNV Profiles 1.0 1.46709 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.887677 GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures 1.0 null ventral linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47572 PRDM1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE219274,GSE219276_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null PNMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95078 Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9942993-pone.0281645.s002.xlsx-AR_as_all_as_lost-ENSEMBL_AR Rummagene Transcription Factor Associations 2026 1.0 null CARNMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70561 TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 138.407 NUDT16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57288 ventromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00708 MXI1 ENCODE Transcription Factor Targets 1.0 null NR1H3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.65388 LRAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39744 CREBBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30069 SUDHL5 DepMap CRISPR Gene Dependency 1.0 2.26932 inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.68918 CJM CCLE Cell Line Gene CNV Profiles -1.0 -1.66972 superficial stratum of ERCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31904 SHOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02157 STX1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34673 GSE135514_8_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20166 TBX21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55736 ATP6V1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56232 intermediate stratum of m2AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18057 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.02388 Respiratory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 NOS-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H6PD_KO_GDS3195_602_mouse_Skeletal muscle - Soleus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ARID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73508 Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_8_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null ATG16L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4651 subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67121 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null ZNF609 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52911 SJCRH30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11292 RBMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10183 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47285 Sarcoma_SARC_TCGA-DX-A3UD-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EDNRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1381 PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210655_3_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null TADA2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40553 CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01666 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TGF-beta_OE_GDS2974_137_mouse_corneas GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A430-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAPK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4306 CERK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13949 ZNF595 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98876 NOP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40077 TUFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51092 organelle LOCATE Predicted Protein Localization Annotations 1.0 null PHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94116 HCC95 CCLE Cell Line Gene CNV Profiles -1.0 -1.59754 hsa-miR-1245b-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.140752 CAL51 CCLE Cell Line Gene Expression Profiles -1.0 -2.13137 OR2B6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85325 FIGLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63014 H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94234 MAPKAPK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6722 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MEA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81546 VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.992547 hsa-miR-3140-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-K1-A42W-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Throat TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TMEM120A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11062 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92601 COLO684 CCLE Cell Line Gene Expression Profiles 1.0 1.49558 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.92929 ECHDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1269 GSE180185_7_v_1_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null COPS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18368 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.978079 AP2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82695 Endothelin pathways WikiPathways Pathways 2024 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NAMALWA DepMap CRISPR Gene Dependency 1.0 2.35985 Lyf-1 MotifMap Predicted Transcription Factor Targets 1.0 null Cortical amygdalar area, posterior part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.96801 Ovarian serous cystadenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 CSTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42776 central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18391 ATCAY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25933 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.66904 8505C CCLE Cell Line Gene CNV Profiles -1.0 -1.35446 GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Parasubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22105 intermediate stratum of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02608 HDAC2 ENCODE Transcription Factor Targets 1.0 null PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3297 GSE74490_0_v_1_triptolide_mouse RummaGEO Drug Perturbation Signatures 1.0 null PNMA6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48356 PMC10591879-NIHMS1933918-supplement-2.xlsx-Down_in_NMR_OPC_differentiation-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_13863_KD_TBX2/MYCN_ERP107244 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.44011 SUCO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82469 ZNF768 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.4222 PELI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58757 Lung adenocarcinoma_LUAD_TCGA-91-6849-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52265 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7278 NCIH82 CCLE Cell Line Gene Expression Profiles 1.0 1.50403 H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRX ChEA Transcription Factor Targets 1.0 null preweaning lethality, incomplete penetrance MGI Mouse Phenotype Associations 2023 1.0 null NCI-H3122 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 JURKAT CCLE Cell Line Gene Expression Profiles -1.0 -2.59415 orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.842693 WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.3418 HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26181 Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null medial pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.04615 PCBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39696 Subiculum, ventral part, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17315 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12543 SLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72397 SRM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5487 SAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5956 PTPN21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05964 TTLL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23845 POU4F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63321 DYNLL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19432 PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Symbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1891 ARHGAP35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27602 RAD50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16394 TGFB2_KD_GDS4483_351_mouse_Embryonic palatal tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H2AL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28258 H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.93874 GSE145323,GSE145324_1_v_0_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null UTP18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32623 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.50322 CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.05764 SGCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38853 MTERF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33149 anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.831329 Cecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 OXCT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67987 AB-97-BI36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.14166 Perturb_13885_KD_CDK4/CDK6_SRP258989 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.64127 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9999213-mmc3.xlsx-DEGs_CSc-DEA_NB_MSC_CSc_vs_NB_CSc_MSC Rummagene Transcription Factor Associations 2026 1.0 null COQ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73815 NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null ZDHHC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62019 SW1116 CCLE Cell Line Gene CNV Profiles -1.0 -1.41421 ACP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74467 496100621_TCx_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02315 Perturb_17806_KO_ZNF675_SRP304971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.70446 HCC1833 CCLE Cell Line Gene Expression Profiles 1.0 1.45885 LMX1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46887 ADAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93869 NCIH810 CCLE Cell Line Gene CNV Profiles 1.0 1.5756 TMEM267 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29147 SSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92718 GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CD200 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55404 TRAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70926 PRRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03932 GSE213153_1_v_0_ulixertinib_human RummaGEO Drug Perturbation Signatures 1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OE21 DepMap CRISPR Gene Dependency 1.0 3.1405 GSE144231_4_v_7_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null HTK CCLE Cell Line Gene Expression Profiles -1.0 -1.46346 PDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56251 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.71166 USP2_KO_GDS5079_25_mouse_kidney GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF574 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.6674 SECISBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04979 ZDHHC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47365 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18347 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VF-01A-31R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_11_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null STAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67922 OSTM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21357 ERCC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02729 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.97361 GOLT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59797 amygdaloid complex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.849597 abnormality of the genitourinary system GWASdb SNP-Phenotype Associations 1.0 0.05703 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15346 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ANKRD63 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87733 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.2573 anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32988 Neck TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55552 COG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63687 H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R1-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_16849_KO_Hnrnph1_SRP068520 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Primary visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02319 PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66205 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.879621 ICC12 DepMap CRISPR Gene Dependency 1.0 2.8569 ventrolateral prefrontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.84482 C3orf80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11113 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.905429 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 YY1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CGREF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92742 WDR82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56877 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5004 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE236262_2_v_1_trim28_mouse RummaGEO Gene Perturbation Signatures 1.0 null Folium-tuber vermis (VII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35858 cerebellar nuclei of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60354 orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37841 Perturb_4221_KO_Utx_SRP117662 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.2762 CTCF ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2917-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.00986 dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85417 Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAMTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47344 DCTD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89637 RAB3GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58578 PMC5575985-mp2016192x3.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null CRLF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68542 GSE165689_0_v_1_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF253 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75306 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4190_KO_Dnmt3a_SRP300442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.15901 NCIH1876 CCLE Cell Line Gene CNV Profiles 1.0 1.62856 microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34887 GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A197-06A-32R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Olfactory ensheathing cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.521 SIK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67083 RRN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88206 Bladder Urothelial Carcinoma_BLCA_TCGA-YF-AA3L-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF331 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.7112 Perturb_2273_KO_Mettl3_SRP110576 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.2274 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RDH11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67712 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.858325 CPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25566 GSE176008_4_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE131798,GSE131804_2_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, mouth, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03203 SLC27A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2516 H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03203 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02028 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NU-DUL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.945335 mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ZDHHC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74068 H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE210101,GSE210114_8_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16376 SAP30 ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LS-01A-22R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_2_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Anterior cingulate area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12668 abnormality of the uterus GWASdb SNP-Phenotype Associations 1.0 0.539082 Ovarian cystadenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02068 TREX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90668 CRAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57458 U138MG CCLE Cell Line Gene Expression Profiles -1.0 -1.54714 PMC3607232-mmc3.xlsx-b_RUNX1_SEM_MLLC_H3K4Me3-x_2_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null posteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1659 CAL148 CCLE Cell Line Gene Expression Profiles 1.0 1.86231 microbody LOCATE Predicted Protein Localization Annotations 1.0 null FAM76B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57997 absent vibrissae MGI Mouse Phenotype Associations 2023 1.0 null PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.818 NASP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28812 SHARPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61251 QPCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46157 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PBX3 ENCODE Transcription Factor Targets 1.0 null BHLHE41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14261 GSE142210_4_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null ST486 CCLE Cell Line Gene CNV Profiles 1.0 1.37168 Perturb_6127_KO_NEUROD1_SRP170936 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.60018 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0153 NUDT22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46131 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TMEM249 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78058 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null COL1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47188 Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.6356 HCC2157 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 ANKS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9295 Uterus-ciliated epithelial cell Tabula Sapiens Gene-Cell Associations 1.0 1.03562 STAMBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16019 dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.01742 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.6151 PROKR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1888 Anterior cingulate area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14592 WM2664 CCLE Cell Line Gene Expression Profiles -1.0 -1.79071 Rectum adenocarcinoma_READ_TCGA-F5-6813-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70969 NKX2-5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null RCM1 DepMap CRISPR Gene Dependency 1.0 2.90237 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39211 TSSC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21554 GSE113734_3_v_0_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null MLL3/4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.218 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Kidney TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NRL_Deficiency_GDS1693_237_mouse_Photoreceptors cells of retinas at P6 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB26 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5759 oval paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02652 ACER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3475 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.868032 parathyroid gland HPA Tissue Protein Expression Profiles 1.0 1.17801 TEX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40798 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20292 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.66733 NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -3.08251 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Prdm14 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8082 Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13843_KD_Fgfr1_SRP371980 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.83979 GSE157960_0_v_3_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null LZTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77038 IRF1 ChEA Transcription Factor Targets 1.0 null SENP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65743 Ependymocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.552 ANKRD13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59421 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.45151 APLN_KO_GDS3228_601_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Uterine body mixed cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 parvicellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81091 GSE131161_3_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCN channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.47 FSBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95183 MTHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11315 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PEBP1_KO_GSE31150_52_mouse_pancreas GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Gene_ID_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.01253 Crohn's disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.764 A1BG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81631 HEB MotifMap Predicted Transcription Factor Targets 1.0 null Tbx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.0252 JAGN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69426 SMAD4 ChEA Transcription Factor Targets 1.0 null ZNF213 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.0116 INA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.072 H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null TXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75591 NCIH1568 CCLE Cell Line Gene CNV Profiles 1.0 1.46963 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null FAM72A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86597 GSE178907_0_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null EZH2_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRKRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47547 NFE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38542 FNDC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13707 Ubiquinone biosynthesis complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.987 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.40142 ACADM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09221 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXA1 ENCODE Transcription Factor Targets 1.0 null Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65702 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.36356 EHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21695 UBE2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4632 HTATSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08915 PRKACG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56549 496100462_PCx_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01097 GSE146687_2_v_6_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null CNN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95195 ZNF66 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00305 CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97338 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03854 Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_12138_KD_OTX2_SRP347033 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.4834 Perturb_8587_KO_Adnp_SRP063269 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.28767 Mel-18_KD_GDS2724_103_human_DAOY medulloblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null plexiform layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46667 Irf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.2072 EPN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20435 inner SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.862412 SYS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42172 RAD21_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null C1orf116 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82576 NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5849 PTPRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8012 APH1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79192 PCCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44838 GATA3 ENCODE Transcription Factor Targets 1.0 null CDON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58217 CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163862_2_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null COA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04559 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07564 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.993926 EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RHOQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70372 SPIRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38714 TES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16584 NCIH1184 CCLE Cell Line Gene Expression Profiles 1.0 1.44517 CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null limb grasping MGI Mouse Phenotype Associations 2023 1.0 null H4C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54457 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05563 VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12739 GSE142210_11_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYTH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97257 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SW 527 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.948714 UBE2J1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12377 AP1G1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85879 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974038 SOX18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71726 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 FAM76A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73724 ventral part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40156 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPRTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15808 ZNF800 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92847 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MLX_TESTES_MLX Rummagene Transcription Factor Associations 2026 1.0 null TRAPPC2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3076 GSE165939_2_v_1_poldip2_mouse RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.890483 ABLIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01197 RAD21_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A6CZ-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3002-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAPZA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.75392 CLMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24788 RGS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03144 EID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66236 mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88844 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE210101,GSE210114_1_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null RWDD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58704 Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GCFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75866 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BHMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9015 CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12543 PKN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35072 PACS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40676 STPG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29764 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6262_KD_NDP_SRP188348 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Rhinitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 CLSTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41164 ventrolateral prefrontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.883177 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.77189 Calcitonin family receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.08 VZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13056 CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.6103 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5692-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-90-7767-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TMEM179B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0433 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45617 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29502 alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.876333 caudal subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.953279 ZNF184 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21935 ZNF384 ENCODE Transcription Factor Targets 1.0 null LARGE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92441 Perturb_17765_KO_Prdm16_SRP238935 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.90066 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885889 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF761 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22225 A-VN-1203-2004(H5N1)_Day2-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.75606 PEBP1_KO_GDS4334_617_mouse_Pancreatic beta cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Parathyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 mantle zone of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08854 ERI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.61342 MTRFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65947 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.24367 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Medial amygdalar nucleus, posterodorsal part, sublayer b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08854 Declive (VI), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21159 Oviduct TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Immune system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.821 mantle zone of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01412 Perturb_13862_KD_TBX2/MYCN_ERP107244 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.39673 NIPAL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90703 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0313 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GAPDHS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46245 LRRC75B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46845 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SCN5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42733 YY1 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_12750_KO_Per1/Per2_SRP315570 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.39518 XIAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23656 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.8726 PARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40971 HDAC2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45118 FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43833 KLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16502 anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11814 Suprageniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23758 SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24198 MEX3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29703 fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.63058 SF126 CCLE Cell Line Gene CNV Profiles -1.0 -2.92482 IRF1-21803131-MONOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-IRF1-HIT_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null FBLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79566 RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1741 NSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65129 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.900224 Kidney Chromophobe_KICH_TCGA-KM-8439-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28769 MEF2A ENCODE Transcription Factor Targets 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSNK1A1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80478 REST-18959480-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GLI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1964 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null CACNA1H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34027 PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1 Rummagene Transcription Factor Associations 2026 1.0 null GINM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.453 PcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34717 NCIH1437 CCLE Cell Line Gene CNV Profiles 1.0 2.74078 GSE198826,GSE198911_1_v_2_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null HNF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36517 shell of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33421 XRCC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31217 Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null HCC2218 CCLE Cell Line Gene Expression Profiles 1.0 1.78017 COLO-824 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 H3K4me1_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17715 AB-85-YK41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233814 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ING1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61736 PGLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55631 ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47788 CEND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14428 EAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4327 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0031 UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.993558 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13556 XPO7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58067 GSE131161_1_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.7288 DCAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56477 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CENPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1632 endopiriform nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00376 Brain Lower Grade Glioma_LGG_TCGA-E1-5311-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.993558 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4222_KO_Utx_SRP117662 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.09482 Medial cortex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.77 P2RX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83389 TMK1 DepMap CRISPR Gene Dependency 1.0 5.86593 TGFBRAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75663 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.74081 sublayer 6b of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05644 NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27907 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B1-01A-12R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ISCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36115 WNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53765 GNMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50999 FOXO3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10733 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6713 BHY CCLE Cell Line Gene CNV Profiles -1.0 -1.37055 MYBL1_KO_GDS4485_350_mouse_Testis from 17 day old GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.933395 Perturb_13380_KO_CTIP2_SRP150394 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.5578 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27545 OXLD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28609 PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06815 CCDC82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20412 FAM78A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6839 H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Set1C/COMPASS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.02 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846035 Sarcoma_SARC_TCGA-SG-A6Z4-01A-22R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFE2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44222 AMO1 DepMap CRISPR Gene Dependency 1.0 3.42402 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit InterPro Predicted Protein Domain Annotations 1.0 null RASA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81222 KLF5_KO_GDS3509_553_mouse_ES cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78903 LNZ308 DepMap CRISPR Gene Dependency 1.0 3.92799 SCC9 DepMap CRISPR Gene Dependency 1.0 2.39355 Primary somatosensory area, trunk, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31904 SPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26462 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TTLL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86828 caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.971846 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68199 RASSF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01859 MEF-2 MotifMap Predicted Transcription Factor Targets 1.0 null MYSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15671 FOXP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90057 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28049 Ventral medial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10652 fallopian tube GTEx Tissue Gene Expression Profiles 1.0 0.974578 Vascular disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.056 TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04796 RAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24311 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS-299 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HNF4A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2808 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.04769 NSUN5P2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68219 first (dorsal) preoptic domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09513 A-CA-04-2009(H1N1)_0Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.74836 Trunk TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE223008_5_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17802_KO_ZNF675_SRP305529 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.70446 SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04287 AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06264 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR3C1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71548 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.830613 Inferior colliculus, external nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48211 SNUC2A CCLE Cell Line Gene Expression Profiles -1.0 -1.51352 TE8 CCLE Cell Line Gene Expression Profiles -1.0 -2.17888 ZNF746 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15254 LYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74192 SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M2-01A-21R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU489 CCLE Cell Line Gene CNV Profiles -1.0 -1.36634 Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.1882 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TADA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68617 PRR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88194 III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.6929 layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33872 cuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18057 MAP3K1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04707 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.97722 SETD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75208 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null OSR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0466 interstitial nucleus of the zona limitans Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14673 r8 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07819 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PREB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51965 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ERMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91129 PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.849024 LNZTA3WT4 DepMap CRISPR Gene Dependency 1.0 11.3363 SH3BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59085 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.32906 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null STN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66008 roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.24225 BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.3998 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80321 fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.15895 DPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36374 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01826 HNF4G JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9746 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPS6KB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21915 PMC9942993-pone.0281645.s002.xlsx-AR_as_all_as_lost-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55118 MRPL45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95001 TBC1D17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44925 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null Ppara JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.3036 GET4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27982 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04919 Lung squamous cell carcinoma_LUSC_TCGA-43-3394-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13948_KD_CDK4/CDK6_SRP258989 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.33677 SNU719 CCLE Cell Line Gene Expression Profiles -1.0 -2.05152 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE210101,GSE210114_6_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GATAD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84167 496100405_TCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01621 NELFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18391 Ciliated epithelial cell_Esophagus_Human CellMarker Gene-Cell Type Associations 1.0 null DAPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43076 ETS1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Large intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ALOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85915 BDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98812 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE216043_11_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4512-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NB13 DepMap CRISPR Gene Dependency 1.0 5.92737 GSE131161_5_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAFG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74579 Perturb_14004_OE_Kcnj2_SRP309478 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.967 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 20300634-T2 GeneSigDB Published Gene Signatures 1.0 null Perturb_12570_KD_MSI1_SRP185353 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.82199 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.44891 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null RASSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04097 DICER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14569 Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42386 striatal amygdala Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03203 COX14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57156 DENND6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52152 GSE213410_2_v_3_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null TBC1D4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26818 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10054 GDAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38578 RINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90885 GPX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83119 Subiculum, ventral part, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22919 EMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2273 Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206870,GSE206872_3_v_2_ascl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12543 H3K27me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GTF2H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42045 LANCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17634 CEP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61051 NCI-H1395 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 SOX13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8559 MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16433 hsa-miR-411 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE109285_3_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null Rostral migratory stream TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.064 Brain Lower Grade Glioma_LGG_TCGA-DB-A64Q-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20987 Perturb_13949_KD_CDK4/CDK6_SRP258989 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.38997 GSE216043_11_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63804 GSE126345_7_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15085 hsa-miR-335-5p MiRTarBase microRNA Targets 1.0 null IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2983-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SEMA4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22196 cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19069 ERBB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02293 NAA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35186 Neurod2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.5236 Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null S1PR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66414 Multiple synapse bouton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.622 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MTCH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.3083 H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70X-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12669 PITPNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.887 CLTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61321 TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91576 medial habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38953 C75 DepMap CRISPR Gene Dependency 1.0 2.0939 ELAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13599 C8orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77473 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.8597 SORT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45217 TMEM221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31419 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cerebellar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39775 LXF289 DepMap CRISPR Gene Dependency 1.0 3.3881 primary auditory cortex (core)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17114 JcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63769 PMC9942993-pone.0281645.s002.xlsx-AR-as_adaptive-ENSEMBL_AR Rummagene Transcription Factor Associations 2026 1.0 null Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48211 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE174701_5_v_2_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null FARP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43595 APPBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13722 PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AQP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18579 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.95616 VZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52945 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12669 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17269_KO_Rfx2_SRP066176 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.46046 PLAGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0719 GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VANGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48183 Femoral muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.835 ALDH4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57167 Primary immunodeficiency disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.821 H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.368321 SARS-BatSRBD_12Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.40506 RNF225 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48202 STARD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29109 CHAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84205 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HOXA11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81098 CLPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58088 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3450-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Respiratory allergy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10097 H3K27me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16433 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6696 nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05201 Entorhinal area, medial part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28149 SOX4 MotifMap Predicted Transcription Factor Targets 1.0 null reproductive system disease GWASdb SNP-Disease Associations 1.0 0.15125 ZNF195 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61667 H3K27me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906672 GSE139455_7_v_6_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null HSPA12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69252 POU4F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38693 AXL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49863 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.938882 mantle zone of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15032 BICR18 CCLE Cell Line Gene CNV Profiles -1.0 -1.47676 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02 superficial stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12306 GMCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18852 RBM46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64875 Lung squamous cell carcinoma_LUSC_TCGA-56-7221-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LNZTA3WT4 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46344 TMEM183A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51833 MPZL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.388 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35253 BHLHE40 ENCODE Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.861277 ABHD17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77244 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44035 Ependymal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.466 NDUFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27036 SYNE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83122 Perturb_9698_KD_SMARCB1_SRP279089 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.49476 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ARHGDIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99349 G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3513 GSE62843,GSE64371_2_v_5_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null FYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25731 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLHDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33418 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GSE143782_7_v_11_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null EFNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24505 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73945 abnormal genital system morphology GWASdb SNP-Phenotype Associations 1.0 0.105255 COQ4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76364 BEST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97602 ANKIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07576 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HMG20B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91977 PMC9942993-pone.0281645.s002.xlsx-AR-as_adaptive_as_lost-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null ELL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40135 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RFX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.941 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59564 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Medial pretectal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.23903 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE136627_3_v_1_hdac4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100285_TCx_probable Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02185 RNASE6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47218 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.16901 MLEC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60826 HMGA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22656 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, barrel field, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14382 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GAL3ST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20009 intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97135 SIGMAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32873 superficial stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8905 ventral paracommissural tectal nucleus, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14511 SALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82052 inner SZ in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.892101 NDUFA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81253 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EIF2AK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71722 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.937281 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46533 LTBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28221 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EC-62-OE64_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.39191 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10656 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6287 orbital frontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.984905 ZCWPW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36283 adrenal gland HPA Tissue Protein Expression Profiles 1.0 1.17801 CIAO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87359 MMAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23527 SORD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76714 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.03321 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PNKP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59046 GSE109285_5_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Radial spoke COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.585 Entorhinal area, medial part, dorsal zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48211 periventricular stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12668 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null AGGF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74213 LIPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54963 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PNMA8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84107 RAB26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61188 TBKBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15091 MRPL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08904 EP300_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FRS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5715 BECKER CCLE Cell Line Gene Expression Profiles -1.0 -1.47425 UACC812 CCLE Cell Line Gene Expression Profiles 1.0 2.49729 Olfactory glomerulus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.91 NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07763 H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02384 hsa-miR-450a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 superficial stratum of PrS (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01995 496100384_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.18708 BBS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17851 H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF684 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.1975 SOX10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.38 MAP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05567 FAM217B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48737 Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43512 dorsal septopreoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06903 Colorectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27818 inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.865664 HBEGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55319 abnormality of female internal genitalia GWASdb SNP-Phenotype Associations 1.0 0.160766 OPM2 CCLE Cell Line Gene CNV Profiles 1.0 1.54777 Cortical amygdalar area, posterior part, lateral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.35918 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.5849 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCM6 CCLE Cell Line Gene Expression Profiles -1.0 -1.91353 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.70372 H3K27me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCKAP5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86744 cell part LOCATE Predicted Protein Localization Annotations 1.0 null ACTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18333 GSE109530,GSE109531_2_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null DTX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02021 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59564 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.48293 TJAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14099 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54671 ventral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12291 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4490_KO_Pantr2_SRP390021 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.09086 H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05981 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Superior colliculus, zonal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09202 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKLMS1 CCLE Cell Line Gene CNV Profiles -1.0 -2.19364 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SNRPD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69454 FOXO1_KD_GDS2720_477_mouse_LSK GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF420 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4481 Interposed nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68087 GNPTAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64582 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NBPF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75641 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null mantle zone of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31904 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.857896 PHGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1751 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2807-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TPMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49711 CGGBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66713 NOMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41362 Cervix carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 inner SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47973 paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.914068 G protein-coupled receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.919 CDH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.755 Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05118 NCIH1395 CCLE Cell Line Gene CNV Profiles 1.0 2.44781 POFUT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.994 ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.3841 Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01995 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.901385 PHF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65157 GSE246461,GSE246463_5_v_0_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null DIXDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55205 GATA2 ENCODE Transcription Factor Targets 1.0 null KMT2E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96052 Attention deficit hyperactivity disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.131 hsa-miR-4663 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 BLZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5888 HOXD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95467 GSE235234_2_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null SNU398 CCLE Cell Line Gene Expression Profiles -1.0 -1.47008 Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IQCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87015 DSP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6551 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0987 SULT4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11833 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2843-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZSWIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57121 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTAGE6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9923 NCI-H810 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 UMUC7 DepMap CRISPR Gene Dependency 1.0 2.93256 H3K4me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_8537_KO_Notch2_SRP152804 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.4495 VWCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84492 CHTOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24802 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.87699 496100491_HIP_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04163 MFE296 DepMap CRISPR Gene Dependency 1.0 6.54623 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_11_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null PCI15A DepMap CRISPR Gene Dependency 1.0 2.26629 Anterior cingulate area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36928 ME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83721 CORO1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32936 PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_15768_OE_Pcbp2_SRP218930 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.7957 Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.698 ALG13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06482 BCL11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63618 H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.918573 EP300 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9591 ASXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23051 Striatum-like amygdalar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00266 primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06774 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CMK86 CCLE Cell Line Gene Expression Profiles -1.0 -1.50207 GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19653 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.15867 Endometriosis_Endometrium_GSE6364 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.31484 GSE187006_0_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216043_7_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GOLGA6L9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26668 VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27119 Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MORF4L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34164 METTL25B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38949 PARP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58461 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RNF114 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11493 EGLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70663 Cortical amygdalar area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68587 NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35544 KLF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 71.7411 TMSB15A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01922 UQCRHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57763 NCIH810 CCLE Cell Line Gene Expression Profiles 1.0 1.38797 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.854662 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13344 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.78593 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COL9A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57669 RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.5043 CCDC61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90336 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26C-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DSCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.76809 Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.48326 PHF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19943 H2AFZ ENCODE Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A8OD-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.49378 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A8YO-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUP43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5868 fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.35582 VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.60024 TMOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11651 Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.131 pyramidal layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04779 TP63 ChEA Transcription Factor Targets 1.0 null VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.867849 NOMO1 CCLE Cell Line Gene Expression Profiles -1.0 -1.62209 Autoimmune disease of gastrointestinal tract DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.821 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27737 H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAGLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74889 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAP2K1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38778 ZNF552 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68176 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.67441 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_14017_KD_PGBD1_SRP398441 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.99016 GSE139455_4_v_6_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null CPXCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95052 PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.03634 PET100 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10244 IBA57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38436 lateral ventricle HPA Tissue Protein Expression Profiles -1.0 -1.03106 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4695334-mmc3.xls-MDA_SMAD3_DNA_Me-Unnamed_2_SMAD3 Rummagene Transcription Factor Associations 2026 1.0 null ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 164.41 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.01115 LTBR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51711 Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3219 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF726 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74721 CHAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63885 TBX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64093 RHNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33069 LITAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78608 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_Fetal Heart Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Superior colliculus, motor related, intermediate gray layer, sublayer c Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58928 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.93797 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF518A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01442 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.67244 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8582123-13073_2021_996_MOESM4_ESM.xlsx-SATB1-HIT_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null Declive (VI), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00999 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.00752 PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1 Rummagene Transcription Factor Associations 2026 1.0 null VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28893 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6508-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.948714 SNU685 CCLE Cell Line Gene Expression Profiles -1.0 -2.34996 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null SPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61849 H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CACYBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00997 DDX19B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27055 LB771HNC DepMap CRISPR Gene Dependency 1.0 10.3783 DMAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10289 hsa-miR-1273c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Ciliated cell_Trachea_Mouse CellMarker Gene-Cell Type Associations 1.0 null C11orf98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43586 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null ventropallial amygdalopiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29063 MEF2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Psoriasis vulgaris_Skin tissue_GSE14905 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.63315 SLC39A13_Deficiency_GDS3485_570_mouse_Chondrocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null C6orf136 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29831 intermediate stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57707 Bed nucleus of the accessory olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00266 NCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70518 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.125 Primary motor area, Layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12974 GSE176093_2_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZBTB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73625 GSTK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57886 YMB1 CCLE Cell Line Gene Expression Profiles 1.0 1.66173 Dorsal peduncular area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10868 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04674 TAB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5902 Excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC9942993-pone.0281645.s002.xlsx-AR-as_adaptive-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null CELF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29496 Brain Lower Grade Glioma_LGG_TCGA-QH-A86X-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Coronary artery disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.056 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Ileocecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20166 SLC7A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03833 KNTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27656 CASP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13087 TOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70828 RHBDD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52346 VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5425 PLBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27447 PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALR_KO_GDS3680_149_mouse_embryonic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SPATA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70325 GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NPAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21727 PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null IFI35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4339 SCN1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1155 PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR Rummagene Transcription Factor Associations 2026 1.0 null ICC108 DepMap CRISPR Gene Dependency 1.0 2.0585 GPATCH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32921 G415 DepMap CRISPR Gene Dependency 1.0 2.21382 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16433 Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.35814 Lung squamous cell carcinoma_LUSC_TCGA-22-5489-11A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67865 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07182 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0425 NTAQ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54537 Ventral posterolateral nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43327 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872304 HMX1_Deficiency_GDS4810_324_mouse_Retinas of C57BL/6J GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GPBP1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74624 Cortical amygdalar area, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.39489 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Vermiform appendix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12543 TMEM92 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7817 BAMBI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37152 YJEFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32478 H3K27me3_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CAPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11595 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TEAD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19585 anterior cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08183 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPRD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72365 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE210662_2_v_0_znf165_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.877497 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AF-2693-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DFFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7804 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP1LC3B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98488 TE15 CCLE Cell Line Gene CNV Profiles -1.0 -2.34111 RFX1 MotifMap Predicted Transcription Factor Targets 1.0 null liver GTEx Tissue Gene Expression Profiles -1.0 -0.832554 dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97177 GSE245390_2_v_1_acss2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PCDHB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76513 RNF2 ENCODE Transcription Factor Targets 1.0 null GGCX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84393 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_11_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null SERTAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28462 SCAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29522 NCI-H1623 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 UROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81978 SKBR3 CCLE Cell Line Gene Expression Profiles 1.0 1.47503 Prostate adenocarcinoma_PRAD_TCGA-CH-5766-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEF2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NB1 CCLE Cell Line Gene CNV Profiles 1.0 1.3849 AKT1_knockout_212_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.75615 Rad17 RFC-like complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.633 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null ANKRD61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09969 DNAJB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85699 Sarcoma_SARC_TCGA-HS-A5N7-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1076_KO_Mr1_ERP107271 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.68242 MT-CO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65857 Adrenocortical carcinoma_ACC_TCGA-OR-A5LN-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE190316,GSE190324_10_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null H3K36me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TVP23B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91215 TAL1 MotifMap Predicted Transcription Factor Targets 1.0 null HCC1171 CCLE Cell Line Gene CNV Profiles 1.0 1.7786 inner SZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.926475 CTSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67338 H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null dexamethasone_homo sapiens_gpl6244_gse20963 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CCNE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56578 H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21505 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE183271_2_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SH3PXD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45031 H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NDUFA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5554 Lung squamous cell carcinoma_LUSC_TCGA-98-A53H-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNFAIP8L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77234 Perturb_8539_KO_Notch2_SRP152804 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 1.04703 anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32459 RABGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66804 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TBX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6408 ADCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63871 HIV-1_LAI_12Hour-UV_treatment_None_GSE56484 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.4905 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.0941 superficial dorsofrontal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53711 LK2 CCLE Cell Line Gene CNV Profiles 1.0 2.15203 GSE151364,GSE151366_1_v_2_taf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null subiculum, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25777 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.743 primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.840543 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.821 SGF29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35997 subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05439 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01405 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARFGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4014 TDOTT DepMap CRISPR Gene Dependency 1.0 6.05728 Ventral posteromedial nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60496 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.33989 Allergic rhinitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 ZNF254 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48574 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19173 RIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06445 ZNF365 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67613 GSE146894_3_v_8_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF644 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46021 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NIF3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90755 REV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68429 H4C13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79487 SHSY5Y CCLE Cell Line Gene Expression Profiles 1.0 1.58827 SLC31A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70004 PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.883353 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NAGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52559 496100410_TCx_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02308 SRY ChEA Transcription Factor Targets 1.0 null Autoimmune disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.821 Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16692 TARBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77044 posterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8845 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_REST_18959480 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MLX_TESTES_MLX Rummagene Transcription Factor Associations 2026 1.0 null Superior colliculus, motor related, intermediate gray layer, sublayer a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07414 MTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57696 CBR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55192 layer 2 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4124 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null GSE182680,GSE182683_7_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44696 primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10908 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POMGNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91306 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67459 SLC3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98643 r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17207 NCI-H2110 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null UBE2E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53805 dorsal paracommissural tectal nucleus, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49772 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33209 9+2 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.032 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5422 CAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77648 TMBIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82525 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM120AOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75788 central part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2112 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70503 ANKFY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74456 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23521 KCMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9768 CSRNP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34949 cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07036 UACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15976 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.844948 BCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47916 superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88773 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE109530,GSE109531_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.956534 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.24102 NHERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2348 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12076 GB2 DepMap CRISPR Gene Dependency 1.0 3.4961 FOXE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18518 GSE133087_5_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null FBXO33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06775 KARPAS299 CCLE Cell Line Gene CNV Profiles 1.0 1.93535 UBXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66368 SH2B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6517 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE94011_0_v_3_pias3_mouse RummaGEO Gene Perturbation Signatures -1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.71968 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KMS11 DepMap CRISPR Gene Dependency 1.0 2.07175 Oogenesis phase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null ZNF318 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63888 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01723 PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2 Rummagene Transcription Factor Associations 2026 1.0 null dorsal spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25457 ZNF443 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67201 YTHDF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65009 Olfactory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01412 MTAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39876 FLO1 DepMap CRISPR Gene Dependency 1.0 2.84654 Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.8225 Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.289 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896925 SPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5917 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_562_KD_LMO1_SRP158473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.21685 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GID8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7728 USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3QU-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14037 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06815 TOLEDO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52134 USF2 ENCODE Transcription Factor Targets 1.0 null VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.83888 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.6011 EIF4H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66148 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fallopian tube HPA Tissue Protein Expression Profiles 1.0 1.17801 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.01981 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4173-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null APOBEC3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89653 SCRN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88138 EP300 ENCODE Transcription Factor Targets 1.0 null Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54625 GSE122215,GSE122217_0_v_1_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906672 FBLIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21975 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_15764_KD_Msi1_SRP218930 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.53674 orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.898953 HEY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75274 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null SEZ6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26533 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_15765_KD_Msi2_SRP218930 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.20736 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.52232 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21126 abnormality of the female genitalia GWASdb SNP-Phenotype Associations 1.0 0.160766 CL11 DepMap CRISPR Gene Dependency 1.0 2.72833 SPO11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12058 ACTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78616 THAP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66462 FKBP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65219 medial (fastigial) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06845 ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.4514 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAQR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41274 YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM129 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82161 ETS1 ENCODE Transcription Factor Targets 1.0 null dexamethasone_homo sapiens_gpl6480_gds3946 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29958 KYAE1 DepMap CRISPR Gene Dependency 1.0 2.85876 inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17004 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE179693,GSE179694_4_v_2_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null DRAXIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67487 HT55 CCLE Cell Line Gene Expression Profiles 1.0 2.0021 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70549 Prostate adenocarcinoma_PRAD_TCGA-EJ-7797-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57669 FABP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01692 TNRC6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22434 mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.97303 RNF181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36481 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null N4BP2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89074 LF-94-HB11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205664 Medial amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27215 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Vomeronasal organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.597 SACS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94904 chr1_151721765_C_T_b38 GTEx eQTL 2025 1.0 1.28242 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.991972 KCND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49919 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.82963 NRL_Deficiency_GDS1693_239_mouse_Photoreceptors cells of retinas at 4 weeks GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K27me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Interanterodorsal nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02485 NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974038 HDAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61598 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SFXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99654 HADH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36372 SOX2-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.08333 USP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85239 TP53BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82255 SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.8158 PARP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60573 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.283144 SPRED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90627 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE248935_1_v_0_cd14_human RummaGEO Gene Perturbation Signatures 1.0 null BEN CCLE Cell Line Gene Expression Profiles 1.0 2.00957 SRY-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2455 CFAP418 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62099 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.983223 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF391 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29373 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18494 PLS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99186 HNRNPUL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99017 YLPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75253 olfactory part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37281 ZNF664 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47219 VIPAS39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30656 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NR2F2_NR2F2 Rummagene Transcription Factor Associations 2026 1.0 null Septohippocampal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29063 DRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24981 mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.02176 PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.3344 UBE2W CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9113 TCEAL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00343 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84443 H3K4me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCC1187 CCLE Cell Line Gene CNV Profiles 1.0 1.67987 ELMO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99015 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84227 Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCH DepMap CRISPR Gene Dependency 1.0 3.19782 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null ChIP_SOX2_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55552 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 67.1462 MOV10L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36432 TOLLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19026 GSE95685_2_v_0_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null VSNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2851 septal organ BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39171 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04415 Perturb_17326_KO_Dis3_SRP328540 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ZNF80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60566 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19987 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16082 Perturb_4908_OE_SNCA_ERP129142 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 superficial stratum of PCPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53675 TCF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19773 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13135 CDK19_knockdown_148_GSE32108 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.53345 B3GNT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00777 SLC10A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87348 H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LRRC58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94224 ventral isthmic part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08854 Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22919 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30607 Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.0 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TPI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62999 ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.4207 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08633 H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36967 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day7-PFU-10^4_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.82452 L3MBTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2108 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null entorhinal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31904 DBTRG05MG CCLE Cell Line Gene CNV Profiles -1.0 -1.37324 RHOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97539 GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null PGBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28769 paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.921564 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RQ-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100459_PCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.50425 GSE172490_0_v_3_junb_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null BCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04989 WDCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45193 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.69175 Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.4226 Esrrg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.0655 RBBP5 ENCODE Transcription Factor Targets 1.0 null AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.753383 SLC4A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47843 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TIA1_KO_GSE54418_266_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mantle zone of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49164 TLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33306 OBSCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2021 PHRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15135 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64253 GNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86045 RNF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL1_KO_GDS4485_349_mouse_Testis from 14 day old GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null DGUOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49457 posteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30009 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7579-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LNZ308 CCLE Cell Line Gene CNV Profiles 1.0 2.14388 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15085 GSE171352_2_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null Ciliated cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null ZNF296 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59604 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01852 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897473 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028422 Perturb_9395_OE_SOX9_SRP201900 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.84998 PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LF-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.918461 H3K9ac_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Subcommissural organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.839 PMC9942993-pone.0281645.s002.xlsx-AR-as_all-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ulcerative colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.821 cerebellar nuclei of CbV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06925 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.52232 Perturb_16845_KO_Kcnj10_SRP241402 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.74956 C3orf52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66221 GSE190316,GSE190324_6_v_11_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null layer 3 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53339 TMEM245 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97223 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974038 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9942993-pone.0281645.s002.xlsx-AR-as_all-ENSEMBL_AR Rummagene Transcription Factor Associations 2026 1.0 null RAB33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11228 lateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22769 amygdalohippocampal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45863 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.49893 Perturb_1075_KO_Il17a_ERP107271 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.36354 TCF23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6617 FAM20C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87551 TSC22D4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27262 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MRPL23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18341 CAMK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57927 C2CD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10494 Stomach TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35255 MRPS33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93429 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rkip1_KO_GDS4331_15_mouse_C57BL/C pancreas GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.896916 MTHFSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1607 hsa-miR-493 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Upper respiratory tract disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.591 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2830-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13091 Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.8772 Nr2f6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 61.9413 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13813 Posterior parietal association areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40156 ZNF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7203 MAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78632