association	dataset	threshold value	standardized value
ESRRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0041471
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34541722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2873
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MIDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19829
8856_TFR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.561816
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.892056
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09611
BRD-K25905181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01892
CAKI1_KIDNEY	CCLE Cell Line Proteomics	1.0	2.13558
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	4.04795
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38487270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6604
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3157
UMUC6	DepMap CRISPR Gene Dependency	1.0	3.05694
HC-01-FD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226551
BRD-K59120074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46235
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4686057-pone.0145107.s001.xlsx-CAA-C-Unnamed_0_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
TOV21G	DepMap CRISPR Gene Dependency	1.0	4.57554
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38604123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54058
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RERFLCSQ1_LUNG	CCLE Cell Line Proteomics	1.0	3.8911
BRD-K04635516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47559
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60454544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43686
p1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.738
PMC4580636-pone.0138782.s005.xls-Sheet1-Table_S3_List_of_Genes_with_RUNX1_binding_sites_in_each_Cytogenetic_Group_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41202439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42633
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10354
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238799
SKMG1	DepMap CRISPR Gene Dependency	1.0	2.14267
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRSS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509662
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261609
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42244
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203165
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08643
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased physiological sensitivity to xenobiotic	MGI Mouse Phenotype Associations 2023	1.0	null
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74091626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22752
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477451
PMC4909395-elife-13964-supp1.xlsx-Sheet1-Supplementary_file_1_shRNA_screen_hits_selective_to_ERG-positive_prostate_cancer_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22216962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24418
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Glioblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.514
BRD-K89364982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39773
BRD-K30201819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06956
BRD-K01716842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70584
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38448
BRD-K55478267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4299
BRD-A48913311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01724
A549_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131294
GSE120612_4_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65597286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61726
BRD-K72773309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2313
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533993
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07343
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WM2664_SKIN	CCLE Cell Line Proteomics	1.0	2.82075
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.79107
BRD-K31796953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07948
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.698
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0913
ZEB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496852
GSE214382,GSE214383_0_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NEURL1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00863843
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
HCC2450	DepMap CRISPR Gene Dependency	1.0	2.75382
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
BRD-K95359959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02924
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.256
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SAOS2_BONE	CCLE Cell Line Proteomics	1.0	2.35887
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
UTP14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90313
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.591217
BRD-K83294522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65538
MTHFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18112
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GGPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15862
GSE186483_6_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84307
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264101
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Unnamed_3_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.5064
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05129
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536047
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95365728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31727
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85216
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98810653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18123
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531121
SLC38A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673551
HS695T	DepMap CRISPR Gene Dependency	1.0	2.90623
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
BRD-K97138361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15911
GSE130437_2_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
BRD-K84013239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4413
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.6995
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NUBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00056
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00773626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00579
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7384
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336685
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220323
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
ACSL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28415
BRD-K88988134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55271
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.60107
BRD-K97421379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0178
Protein hydroxylation	Reactome Pathways 2024	1.0	null
HL-60 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.296
BRD-K75325409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43608
PMC11295044-pnas.2403331121.sapp.pdf-33-ZMAT1_ZMAT1	Rummagene Transcription Factor Associations 2026	1.0	null
HEC265	DepMap CRISPR Gene Dependency	1.0	4.16618
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84094
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0417
BRD-K41033271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37374
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3012
GSE203308_9_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265927
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6964
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-KIM_MYC_AMPLIFICATION_TARGETS_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45959036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06375
Adult Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
MEL290	DepMap CRISPR Gene Dependency	1.0	2.76261
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37115
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4105
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352392
GSE198165,GSE198166_9_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLAMF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506282
GSE220520_5_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13110695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00351
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286905
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN008_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04612
BRD-K07706477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16723
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.05199
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4195
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.695009
decreased inflammatory response	MGI Mouse Phenotype Associations 2023	1.0	null
P-TEFb complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
SUSA	DepMap CRISPR Gene Dependency	1.0	2.06547
Glioblastoma multiforme cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.685
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44548010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11288
BRD-K74173779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48307
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71723
PMC2241646-1471-2105-8-386-S2.txt--XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10092312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5686
dolichol-phosphate-mannose synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.672
BRD-K88478877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00077
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00424888
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276762
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
FPGT-TNNI3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564415
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410981
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8187
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.712
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34274486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25887
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.54
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48020855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11783
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215062
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0154
ADAM28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546797
BRD-K68663367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21782
PEX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50668
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139872
histone H3K4 demethylase activity	GO Molecular Function Annotations 2023	1.0	null
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87865
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4249
CRCGN010_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31487
GSE214823,GSE214824_3_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6824
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62325456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57238
BRD-K01676126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10823
PMC7310287-12964_2020_604_MOESM3_ESM.xlsx-GSEA_official_gene_set-DANG_MYC_TARGETS_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359477
BRD-K77535986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04311
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7804
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.69954
SLX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47786
BRD-K22797212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09081
679_ATP6V1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.534933
GSE93156_1_v_0_idelalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70941721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01918
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269759
BRD-K72842159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05067
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135735
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7775
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27239
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
XC-88-ZM66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279053
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1301
BRD-K24494475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.354
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12566
WM115_SKIN	CCLE Cell Line Proteomics	1.0	3.43351
Gastric Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K30977850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14214
GSE153871_0_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.416
BRD-K81881801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07661
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12985
FGF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055219
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.643128
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MMS22L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25164
AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39275
Central Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nucleoli	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
BRD-K41102088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07898
NUSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02553
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36316
PMC11266089-Table3.XLSX-Fig1_Disease_targets-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38929751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08413
GPRASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10539
BRD-K35625946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43714
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265972
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94573433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71222
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-hgnc_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34425773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04916
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.8132
BRD-K44341877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42045
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Astrocytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.503
PDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627254
BRD-K64770897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.169
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20072174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4337
PGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564605
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20702
FURIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620575
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CYP11B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596318
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
HC-18-NB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201438
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614581
BRD-K66287173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96386
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00326
HSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83727
CATSPER2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632499
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
ANO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678536
GSE111102,GSE111105_8_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GABRA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516804
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59575
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.62
PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82765368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97202
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1951
BRD-K37872081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40982
BRD-K47443098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15878
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62977
IFIT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04913
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0586
PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265058
BRD-K84716908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74754
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4318
7493_RPP40_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51482
BRD-K68433511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12846
GSE138815,GSE138817_3_v_1_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1125
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.11657
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TUBB2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591989
BRD-K94697940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0949
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01564
BRD-K06367273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0026
BRD-K45723655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14872
BRD-K20542687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88013
GALNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654415
BRD-K79020643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49681
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.608385
KAT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535608
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.636
BRD-K99522349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38925
histone H3 demethylase activity	GO Molecular Function Annotations 2025	1.0	null
Asthma	DisGeNET Gene-Disease Associations	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3027
Adult Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.9924
HUPT4	DepMap CRISPR Gene Dependency	1.0	2.93773
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64665
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6814198-NIHMS1538462-supplement-2.xlsx-LateUp_162genes-MEOX1_MEOX1	Rummagene Transcription Factor Associations 2026	1.0	null
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6711
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07534805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24392
BRD-K14082333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13142
BRD-K17185909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04854
ROGDI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32348
FHAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564038
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11133462-41467_2024_47218_MOESM5_ESM.xlsx-IL-10_SBNO2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63667
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27485
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.607
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86192746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18871
BRD-K18621941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31847
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.196
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60850201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02207
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21433749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54819
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04119
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138449
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.16799
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14323
BRD-K36252987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09739
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231799_2_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64117
BRD-K75207324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85241
BRD-K03489727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37022
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17284
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
Lsd1/2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HEC1B	DepMap CRISPR Gene Dependency	1.0	2.04237
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HULC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.714
BRD-K39985369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60114
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31393518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03822
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509758
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0475
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2963
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
BRD-K03309398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15522
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
BRD-K02484256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01681
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1015
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
HHEX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00499591
5075_RIOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.532827
Esophageal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K96981233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04564
BRD-K88328128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84969
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FUT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052183
BRD-K92565319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66136
DD-49-YG96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28521
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_6_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05123945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57827
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.96828
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94866
BRD-K84874502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11217
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018381
RNASE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2368
BRD-K09295309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72445
BRD-K90526956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03879
BRD-K28926538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30409
BRD-K64763786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81591
CE-00-EK89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351607
BRD-K20361257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1937
GSE144484_2_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K40116023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04246
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bile duct disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
BRD-K12306640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35381
NCIH2052	DepMap CRISPR Gene Dependency	1.0	2.83476
PMC10635891-mmc2.docx-18-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal circulating interferon-gamma level	MGI Mouse Phenotype Associations 2023	1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2206
BRD-K56957303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30895
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	75.7497
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18459
BRD-K11251396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02423
TC71_BONE	CCLE Cell Line Proteomics	1.0	3.79639
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.647
RAB6D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64846
nuclear lumen	GO Cellular Component Annotations 2023	1.0	null
NUP214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82341
DAGLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483933
KNS42_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.21357
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67238
BRD-K03733288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00067
BRD-K98880643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33721
BRD-K00797068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46167
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TIE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579577
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38733
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29732
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17236
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE99112_0_v_1_upf3b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147943_4_v_6_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Esophageal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
BRD-K79678951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18058
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22919
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22177
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99452971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24549
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43975
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAGED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27239
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.83734
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.561918
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06398
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96440230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83591
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21152
RPE1SS51	DepMap CRISPR Gene Dependency	1.0	2.24285
XBP1P1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00873089
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50987
BRD-K96970199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61735
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.973958
BRD-K17231179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07397
SNU1544	DepMap CRISPR Gene Dependency	1.0	4.31697
WM3772F	DepMap CRISPR Gene Dependency	1.0	3.2111
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.93765
Thymoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59851511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60405
GSE94849_7_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53199675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10762
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24895
BRD-K53402320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08454
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188814,GSE188854_0_v_1_wtap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PCDH17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701958
BRD-K18978916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03038
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1217
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37402529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06794
BRD-K00423214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38744
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39809702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06726
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MM1-S cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80057
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256916
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08182
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_29_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.79639
WWTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482593
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276863
PSMA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571922
BRD-K92650579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81069
abnormal circulating interleukin-4 level	MGI Mouse Phenotype Associations 2023	1.0	null
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432716
1784_COPS7B_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528487
BRD-K46313713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63683
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51825
PMC12865287-fmj-12-040-s001.pdf-11-PCGF6_PCGF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79322550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40039
a2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.705
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38035271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06861
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435894
NUDT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29522
PPP1R16B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505296
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.9912
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12444
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626504
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.9662
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00857
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0218
SETD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68307
TARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11931
OCRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695458
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K14087001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08398
BRD-K72034681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80801
IL1R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501272
BRD-K64753899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06132
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32146
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.82218
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.28142
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319641
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57855
HPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573382
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.773
BRD-K24385654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55556
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227573
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.08086
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF790	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.271
GSE186440,GSE186443_3_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TTI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23491
BRD-K82021299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11859
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59535
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95648
CORL279	DepMap CRISPR Gene Dependency	1.0	2.6997
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.08548
BRD-K63809385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78979
GSE192689_0_v_3_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
TIMM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00454
NDUFC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045686
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.470243
Granular component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.399
BRD-K50260295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35659
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SYMPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75388
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08516
TPH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00508707
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.54
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34804325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88547
FACT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
BRD-K43570522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02433
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAWR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663264
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
ATP2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32947
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
BRD-K22672200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36955
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.68327
BRD-A68427178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17814
PMC4490555-ncomms8289-s8.xls-PRISM_Site_Overlap_Matrix-Gene_names_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63997411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2442
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.828373
PMC7833686-mmc5.xlsx-e_q1en30_v1-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
SCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0555
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6865
LYSMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00803433
BRD-K78615842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09568
RPE1SS6	DepMap CRISPR Gene Dependency	1.0	2.85377
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.724
CAV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655198
PMC7248321__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ER body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.752
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2-oxoglutarate-dependent dioxygenase activity	GO Molecular Function Annotations 2025	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308861
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3471
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43996
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36120694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3531
BRD-K62018188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12445
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45062933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64017
BRD-K13146924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20151
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Smad4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.75
GSE178340_7_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bile duct adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44042747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30246
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31546068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35283
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
BRD-K19573822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12651
BRD-K72685049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22168
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0964
BRD-K06264262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8011
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1286
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.30353
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288742
BRD-K63189715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08788
BRD-K60729758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38327
AAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00792194
BRD-K08359838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08723
BRD-K46924722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06743
GSE218960_0_v_1_nrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cyclin/CDK positive transcription elongation factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.074
BRD-K71514806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29101
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05635176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08926
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-ensembl_gene_id_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32378
BRD-K77324165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30878
WM88	DepMap CRISPR Gene Dependency	1.0	3.70282
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
BRD-K14233531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33327
NDFIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00409324
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.3387
BRD-K20142115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47341
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF396	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14292
BRD-K35108166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83867
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
IPCEF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00797326
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K83115645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25273
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2BC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49803
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3b_DirectGene_FOXA1-Data3b_Genes_directly_regulated_by_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
KDM3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497705
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K88200990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00163
BRD-K56283394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31155
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46149455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15873
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
MS4A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607396
BRD-K13119652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03583
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88128293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23346
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23617623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64964
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11873306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34197
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266331
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32217
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.772027
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91726436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01676
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154936_3_v_4_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115424
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07453
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386453
BRD-K97595801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19648
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25173
BRD-A71962374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08367
BRD-K56618252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64419
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80689
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00944
BRD-K40733000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57265
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36118
BRD-A19912945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09185
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47164766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23242
CDC42	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00396607
GSE135514_8_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.635
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28399883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37858
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1481
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24211
GSE147943_7_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MARK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614007
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70468140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23526
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214823,GSE214824_3_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bile duct cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
C11orf98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71748
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDMs demethylate histones	Reactome Pathways 2024	1.0	null
BRD-K45677957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02042
H3C13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12653
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.05083
Brain cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.484
T-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.11
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
BRD-K04181823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13556
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-8.06137
BRD-K77940693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53582
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K51502220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65309
GSE210101,GSE210114_1_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IDO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597658
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84693638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04408
ABT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54274
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325535
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77364
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13717
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.004809
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NZM42	DepMap CRISPR Gene Dependency	1.0	2.92548
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0464
BRD-K32854540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08115
PMC9306206-12915_2022_1367_MOESM6_ESM.xlsx-Table_S7_-_JIP-Gene_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00378498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25719
GSE186483_2_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8203
DMS273_LUNG	CCLE Cell Line Proteomics	1.0	2.28655
CLIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072875
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.54
palmatine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1187
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MERO14	DepMap CRISPR Gene Dependency	1.0	5.58384
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.58708
NAA50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10011
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98791
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52319351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06286
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.51148
BRD-K66831269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33859
BRD-K94411351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58074
TPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0043593
PROC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00493044
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7975
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13303
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501063
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27478
PTPN22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639711
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SEPTIN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27424
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5971
BRD-K77624847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22939
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.3922
RRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102612
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502813
ZSCAN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41389
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.69317
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
BRD-K33767223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83958
Childhood Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE96641_3_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OCIC4P	DepMap CRISPR Gene Dependency	1.0	2.03
Arteriovenous Fistula	DisGeNET Gene-Phenotype Associations	1.0	null
NUGGC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064595
HD-26-KX74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256413
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193624_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.42253
BRD-K25328765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23683
GCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063735
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Renal papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
HONE-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.30325
BRD-K64329997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21566
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
BRD-K51707293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02882
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305709
FCGR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569345
BRD-K33757887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05531
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WDR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20551
BRD-K80803211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82996
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.535886
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.7582
BRD-K79781106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60134
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21985
GSE215086_0_v_1_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73014869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3117
GSE210101,GSE210114_1_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51131
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69082321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48076
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K66470464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.793
BRD-K25649596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49803
A549	DepMap CRISPR Gene Dependency	1.0	5.58517
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86645
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486083
BRD-K87418665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28911
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86515
TASK1	DepMap CRISPR Gene Dependency	1.0	3.96566
496100445_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13316
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.53895
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
32D clone3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
CRCGN015_HEPG2_48H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11707
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-NR2F1_Ind_DN_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
ALOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00428915
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_MYC_TARGETS_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11698
Childhood Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17120673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.104
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95485901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22552
BRD-K83012560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13867
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21285
A427	DepMap CRISPR Gene Dependency	1.0	3.96993
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-CCRF-CEM_SCR_vs_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28021686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82564
BRD-K45076286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.701
KCNV2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561055
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73352
BRD-K39752756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17742
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16031
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47002
BRD-K25187028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25504
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	4.39717
PKDCC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540665
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178340_5_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23442578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27697
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44203030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11368
NP-69 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28848
BAIAP2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62168
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
DRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511359
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220942_2_v_1_galnt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10415
Childhood Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K56301498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29714
Astrocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.489
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.223
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57155690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01378
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.068
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214823,GSE214824_4_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72549552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15363
CELA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00757396
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1337
PRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00423576
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82284644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27883
RSC-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.957
BRD-K15882320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01678
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.650172
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63271
BRD-K15478481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05831
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94277689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01585
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02569
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
PANC0504	DepMap CRISPR Gene Dependency	1.0	3.34556
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SEPHS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681284
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3789
RFXAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00756808
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217529
Multiple Myeloma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K66030669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25335
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNRPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35623
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07398
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452659
KCNN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00723077
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8759131-advancesADV2021004469-suppl2.xlsx-Table_S1-Supplementary_Table_1_Differentially_expressed_genes_post_knockout_of_MEF2D_in_MOLM-13_AML_cells_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36271521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27528
AGS	DepMap CRISPR Gene Dependency	1.0	3.06037
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85905
GSE86021_0_v_1_crenolanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_BOUND_BY_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
5054_MICAL3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512601
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6045
GM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00694116
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75977
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14554
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.49565
BRD-K62372121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46861
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
BRD-A94740628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10097
Mpk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
MERO95	DepMap CRISPR Gene Dependency	1.0	4.97656
BRD-K20077349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47539
PMC10528072-NIHMS1928302-supplement-5.xlsx-NEUROD1-target_genes-AANAT_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05096562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09093
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10738
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE60367_2_v_1_cxcr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.739
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
BRD-K19009595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22283
BLOC1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1285
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.667
PMC12616242-can-24-3452_supplementary_table_s6_suppst6.xlsx-EWSR1FLI1-KDM6A-targets_down-EWSR1_FLI1-KDM6A_downregulated_targets_upon_KDM6A_knockout_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99446825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15409
GSE153189_1_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CFP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661566
DENND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46226
GSE138672_4_v_3_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159206_1_v_3_drd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.308
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15757
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01743
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.31967
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100635_HIP_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29267
PMC4728380-ncomms10153-s8.xlsx-High_affinity_MYC_Targets-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67464
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18085
RPL37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501477
BRD-K99728124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46308
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49992772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39263
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32853527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14805
BRD-K31021810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5031
BRD-K15300571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42954
nucleolus	GO Cellular Component Annotations 2025	1.0	null
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86748
FD-20-OG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216312
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0561
BRD-K38917645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6441
A375SKINCJ2	DepMap CRISPR Gene Dependency	1.0	2.09996
BRD-K86988191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23047
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74680333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6251
RT4_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.56463
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.49362
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20003
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.17862
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25470159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13132
BRD-K53095870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12591
CDKN1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0043759
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.432
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0343
GSE227137,GSE227139_0_v_1_themis2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12930517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11474
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232675
BRD-K67740871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17099
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2756
MEX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30529
CDK18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41256
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47303
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-EN2-sequence_name_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48717
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleolus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.686
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF774	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14587
RPS17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551873
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18296568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07277
BRD-K39534157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78967
TNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5894
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66941670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49846
BRD-K60751806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10491
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04654
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70533557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61619
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FCRL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505295
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SETD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522265
Abemaciclib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258645
MRPL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06927
AARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50495
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96102
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2048
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41329
Hepatitis B	DisGeNET Gene-Disease Associations	1.0	null
MRPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02727
Nonhomologous end joining complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.519
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334269
BRD-K25917968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10815
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.367
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.730862
BRD-K43205312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33176
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6324
GSE144484_0_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08940439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0362
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59875
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44007425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.666
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75967530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07552
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4119
Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
496100404_PCx_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.74657
BRD-K15282657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74149
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81107
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4489
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.03801
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
KCNE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00726192
MD-86-UW46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221986
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Allergic Asthma	DisGeNET Gene-Disease Associations	1.0	null
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43981353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35101
TIRAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503042
BRD-K58883090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34194
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.38392
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59913416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87623
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0394
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99300752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16863
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1878
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.14087
ASCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0202
BRD-K34475679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01069
histone H3K36 demethylase activity	GO Molecular Function Annotations 2025	1.0	null
KNS81_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.0215
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9545
BRD-K26631178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47465
NCKIPSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00351
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3273
n18	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.529
2-oxoglutarate-dependent dioxygenase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K44292107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03676
BRD-K96596828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59228
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.556526
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EW22	DepMap CRISPR Gene Dependency	1.0	2.78281
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2473
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
DNASE1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33262
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25408656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06328
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.365
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GRIN2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0044587
A549_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161699
BRD-K59507567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33719
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613946
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19714
Squamous Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
abamectin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68579
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
KP2	DepMap CRISPR Gene Dependency	1.0	3.24003
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
BRCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47068
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8225
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UPCISCC200	DepMap CRISPR Gene Dependency	1.0	4.93021
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235335
VPS45	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665356
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5387
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.559085
PMC4695334-mmc3.xls-HCC_SMAD3_DNA_Me-HCC-unique_genes_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PLK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00529689
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262028
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640292
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555384
NCI-H929 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.738
PMC2694838-1471-2164-10-241-S3.xls-Sheet1-Commonly_altered_genes_by_ZNF191_overexpression_and_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPPL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01322
BRD-K01266518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10637
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99131664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77182
GSE220520_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ACADM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675017
BRD-K72647169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68759
Hemophilia	DisGeNET Gene-Disease Associations	1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77547131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88627
EIF2S1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00962917
LSM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00498281
PMC3076323-pone.0018064.s016.xls-MYCN_targets_Marson_GSE6007-Unnamed_1_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56783915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14139
Silicosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.54
Glioblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.498
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6859
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1903
Cerebral Vasospasm	DisGeNET Gene-Disease Associations	1.0	null
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
AM38	DepMap CRISPR Gene Dependency	1.0	5.83628
BRD-K33453127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39818
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	2.72945
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.48
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4803
FPGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18136
BRD-K57972271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40605
GSE225141,GSE225143_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168076,GSE168080_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81982648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47107
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13358
COLO829_SKIN	CCLE Cell Line Proteomics	1.0	2.70506
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663979
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73942403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31904
GOLGA8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00414324
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217973
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229435
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52183
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6296
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IL1RAPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053877
JMURTK2	DepMap CRISPR Gene Dependency	1.0	3.38221
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57506
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29232
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348895
A3KAW	DepMap CRISPR Gene Dependency	1.0	4.30543
PMC4913876-NIHMS68258-supplement-Supplementary_Table_6.xlsx-ClinSIG_MYC_logFC_LIMMA_q-sig_o-Ensembl_Gene_ID_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K40548004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41596
PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nctcclone1469	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17793
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
BRD-K34839838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06385
ARHGAP31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496227
BRD-K52428486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53076
BRD-K59856141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04995
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0212
Intestinal Metaplasia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.87626
ADH1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00724459
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99125195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18546
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95738
DC-45-WU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239584
Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34602185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20283
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3305
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K51978501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34767
BRD-K35462157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1261
BRD-K44696459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29795
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7344
GPRC5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00431889
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
carboxy-terminal domain protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.068
BRD-K54769228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14854
Anastomosis	DisGeNET Gene-Disease Associations	1.0	null
2313287	DepMap CRISPR Gene Dependency	1.0	2.87739
BRD-K46561246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13288
BRD-K23857235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40089
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39017
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70154746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24289
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Alveolar macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.701
Sin3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7816
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502161
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62909
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.31789
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-GeneID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24133999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00624
BRD-K12841150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01581
CLEC4E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580286
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72863
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37971917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15056
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10061
BRD-K86454955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45168
BRD-K25193509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04414
PYCR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48626
BRD-K77320034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36512
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49135
BRD-K21327356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18406
PBMC cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FNTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00701352
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13542161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26125
BE-42-IC00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284977
Ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.004
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
histone demethylase activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K54141134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74551
BRD-K65440031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15838
PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
CRCGN012_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21433
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40760168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.064
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88786
BRD-K96280720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12784
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275671
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6396
BRD-K51608228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15554
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3116
histone demethylase activity	GO Molecular Function Annotations 2023	1.0	null
A549_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119112
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
BRD-K59606563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30251
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62418398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49333
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.54
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92974694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12233
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3506
BRD-K16330310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87834
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.1876
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.75885
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1525
KYSE30_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	3.57747
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRKN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00508158
BRD-K54593730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22712
BRD-K77354492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30927
ERN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558298
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.582716
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81619018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14544
BRD-K02321382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10138
HEC59	DepMap CRISPR Gene Dependency	1.0	3.6203
BRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506354
RDX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546478
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39803
BRD-K22229548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35293
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.586426
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70255
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3024
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33511
RCCFG2	DepMap CRISPR Gene Dependency	1.0	2.18189
BRD-K91423144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6413
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52285987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35886
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
Plasmacytoid dendritic cell_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03417
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_Targets-Unnamed_9_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.482982
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6849
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224463
BRD-K56893290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15568
PI4KA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503007
BRD-K77634878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79816
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
ACTR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00391703
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.442162
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1379
BRD-K45813167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15195
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1361
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
Advanced Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-A11130173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10067
RAI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590452
ITGB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508147
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
AOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00382569
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.793634
CSAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502576
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3067
Subarachnoid Hemorrhage	DisGeNET Gene-Disease Associations	1.0	null
WC-59-RG09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20537
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189359
mRNA cap methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
KCNK13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560715
BRD-K95788660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05267
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282511
BRD-K32925057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07889
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.77118
Pyrenoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
Cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
EVI2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585703
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3044
Rixosome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.631
CIB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555432
EEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22694
histone H3K4 demethylase activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4963
BRD-K37740343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46508
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86285108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22381
BRD-K20348534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14965
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19691332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56902
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28391526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08656
BRD-K48221699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72059
PMC11062920-41586_2024_7300_MOESM3_ESM.xlsx-Sheet1-FOXO1_regulon_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41396351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34031
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346115
PMC8790372-rsob.210305.pdf-45-selected_targets_for_assay_validation_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48836
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CLN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553284
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
BRD-K90358614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34966
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176939
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-HL-60-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_HL-60_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64692525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97904
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78647367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65841
GSE185953_2_v_3_tlr3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KIRREL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71859
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.15752
BRD-K27600134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25166
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222371
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37092508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09276
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50709
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNRF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14844
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1635
BRD-K77023196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43547
BRD-K29662589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72511
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143692_0_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
BRD-K89199943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5296
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98726
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
BRD-K18128277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16464
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534729
BRD-K38046923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03298
decreased eosinophil cell number	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59753
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29914
BRD-K11752384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0125
NFKB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.013331
BRD-K91039552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53565
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Periodontium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.375
QDPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563484
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66207462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3628
CPSF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39563
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.37696
PICALM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510098
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
CLK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641301
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17662
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.09305
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64268886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30052
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145915_0_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CFAP46	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00711858
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE94849_1_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04695993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7101
GSE215086_5_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0327
SLC35A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05296
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HSPA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0143681
decreased macrophage cell number	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8503
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bronchial epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.383
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0977
L3MBTL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1044
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BIRC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2288
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124014_0_v_1_nnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29148
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160817_0_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15258
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	3.40889
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23795
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07347
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298063
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244494
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49772
BRD-K98793503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32486
RSL1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27995
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3938679-pone.0090284.s007.pdf-22-ZBTB20_ZBTB20	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-CON_VS_LPS_252-Gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69706
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8776
KLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06705
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.801873
COLO-699 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6098
VAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557234
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19764912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6371
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3898
TMEM150A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40047
decreased neutrophil cell number	MGI Mouse Phenotype Associations 2023	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446354
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319059
GSE221742,GSE221743_1_v_2_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231720,GSE231724_3_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188171
NCIH1648	DepMap CRISPR Gene Dependency	1.0	2.53837
GSE231720,GSE231724_3_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K39328339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09303
A-549 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.455
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
K562_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151148
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71419092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67447
HLF	DepMap CRISPR Gene Dependency	1.0	3.10708
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FCGR3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604537
Bronchial epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.433
TTC642	DepMap CRISPR Gene Dependency	1.0	2.95472
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47275094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03004
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24503
MEOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00711251
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
NC-27-AD53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.550041
GSE216394_2_v_0_pfkp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SACM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15189
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07905
BRD-K30285881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60779
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.72
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Papillary Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S12-ZNF384_DiffExprGene-Unnamed_1_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00242
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47263
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
KPT-185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54039
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.7782
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GART	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00729816
SHPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00717783
BRD-K68301602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38656
HNRNPLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69861
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.13088
BRD-K97122937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0583
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569266
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Euchromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.281
ZNF70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09837
MMP20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00448501
BRD-K85909950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65129
BRD-K85456301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02305
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1901
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
CRCGN015_HEPG2_48H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08608
RPS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644043
BRD-K48408404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90006
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21826560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33771
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.68369
HLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31151
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64085
CRCGN016_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23514
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38632
Hurthle Cell Tumor	DisGeNET Gene-Disease Associations	1.0	null
histone H3K36 demethylase activity	GO Molecular Function Annotations 2023	1.0	null
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7514
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.637061
abnormal immunoglobulin level	MGI Mouse Phenotype Associations 2023	1.0	null
ZFAND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40174
CSK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00336879
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10248509-Data_Sheet_5.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_AND_GSE41177_DE-Genes_NOT_Autophagy_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SNU449_LIVER	CCLE Cell Line Proteomics	1.0	2.20182
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28269391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08155
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.793957
GSE149760_3_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37545
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
VNN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521816
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92079609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64321
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DU145_PROSTATE	CCLE Cell Line Proteomics	1.0	3.47924
TMEM120A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482309
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_NOT_Autophagy_NOT_GSE22255_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148647_4_v_2_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541104
CRCGN016_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16037
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27511
BRD-K09871160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0982
BRD-K84310612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36264
BRD-K91094364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15309
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27228
CRCGN008_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0303
Epididymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
BRD-K41603100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20967
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521485
BRD-K35587518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15591
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adult Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K63761383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29885
PRKAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97785
Metabolism of proteins	Reactome Pathways 2024	1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IL2RG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00850361
BRD-K28545166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10817
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-AA_DN_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	1.0	0.795857
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.14642
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91410469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49458
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
BRD-K92825272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21831
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CACUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33997
ADCY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005784
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43033
MZT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03826
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4228
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.14413
BRD-K11844860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92451
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32522654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09908
BRD-K19457629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44841
Chromatin modifying enzymes	Reactome Pathways 2024	1.0	null
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04575
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230799
SUNE-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.508
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1891
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.7074
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0858
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203308_15_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MHHNB11	DepMap CRISPR Gene Dependency	1.0	3.40347
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71460915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12052
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8723
LS180	DepMap CRISPR Gene Dependency	1.0	2.27615
BRD-K95410891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49638
BRD-K45819372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50889
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8181
BRD-K41888813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44363
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.13865
Preribosome	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
BRD-K54879095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68072
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76984291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5632
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203308_4_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DHX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77668
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3203
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70652938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09179
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54351451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30423
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235584
TGFB1I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31253
NCIH23	DepMap CRISPR Gene Dependency	1.0	2.01834
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPHK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657844
BRD-K96491664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04153
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72034944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20092
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229927
MAP3K12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45276
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2961
496100392_HIP_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20935
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
ULK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537619
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
KRR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20881
OE-78-XD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238985
MCF7	DepMap CRISPR Gene Dependency	1.0	3.15763
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73802986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8307
Recurrent Tumor	DisGeNET Gene-Phenotype Associations	1.0	null
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5827
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38028
BRD-K42506600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63893
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05269173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21594
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	Reactome Pathways 2024	1.0	null
PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-LPS_VS_LPS_PDLSC-CM_776-Gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BPH1	DepMap CRISPR Gene Dependency	1.0	2.11289
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.525272
SNU5	DepMap CRISPR Gene Dependency	1.0	2.57543
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1119
ETV4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647923
PMC7021759-41467_2020_14682_MOESM10_ESM.xlsx-upregulated_genes-Table_S7_Upregulated_genes_in_SKNMM_and_U2OS_cells_with_MYCN_induction_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
TLR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581674
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.601224
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.072
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.5298
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011994
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81599
Plastoglobule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
BRD-K85271599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06581
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.631148
BRD-K07414059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45239
CD2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44808
BRD-K92356505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09062
BRD-K99127896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93704
BRD-K21409337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02971
BRD-K65888165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93599
BRD-K51320582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51831
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K37625653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15144
MAP3K20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506114
BRD-K55896279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05476
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC7A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55618
GOLT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24781
BRD-K23204014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38018
Corpus epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.16
BRD-K21167361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31356
FDCP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.396
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.367
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73146
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2098
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39998
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.3407
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96417480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55194
BRD-K89305325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08027
nuc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.421
BRD-K81956993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24922
BRD-K67508052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10527
NDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56698
FOXQ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585348
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.916
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A47416464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05064
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.58247
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1013
BRD-K15460257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13874
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RPE1SS77	DepMap CRISPR Gene Dependency	1.0	2.77743
Stage, Endometrial Carcinoma	DisGeNET Gene-Phenotype Associations	1.0	null
MERO48A	DepMap CRISPR Gene Dependency	1.0	2.4644
BRD-K34519170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24161
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
ZC3HC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07557
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45398957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23034
BRD-K85656316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18685
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.607623
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cytosolic large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.26752
VANGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585231
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
EPX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601177
BRD-K16251850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11949
BRD-K96641838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20779
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
RSPO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552777
BRD-K54453373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90393
BRD-K65910757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33681
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A63503250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10453
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.355
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52119965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0192
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225447_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UPCISCC116	DepMap CRISPR Gene Dependency	1.0	2.79727
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90052868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2682
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210861
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.879329
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0899
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69269415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29808
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71566411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41827
GSE198165,GSE198166_5_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14653235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03107
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.556248
BRD-K00411149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63415
PAAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06726
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30019337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27834
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Esophageal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20528
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68939871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03212
Promyelocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59962
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2629
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gingiva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.464
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	208.568
BRD-K41305193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66675
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K79908599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00811
GSE164757,GSE164759_4_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31273080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05621
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HMGCS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00397261
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145215_2_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28505
AMMECR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10981
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235069
BRD-K30661365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05424
CRCGN008_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3829
Glucosidase II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.73333
BRD-K28746174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24546
BRD-K70158474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32359
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88467167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06432
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31826
Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
FHIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525642
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BMPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781782
BRD-K66909712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02973
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133516_5_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4147934-1755-8794-7-50-S3.xlsx-gene-set_table-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299443
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23194
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14383
CRCGN011_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01883
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K36944891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07929
BRD-K73027631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12783
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3371315-NIHMS350140-supplement-9.xls-MCF7-T47D-SK-453_Up_MCF7-T47D_x-Supplementary_Table_2_ER-positive_FOXA1_signature_Genes_increased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36134264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06273
SNUC1	DepMap CRISPR Gene Dependency	1.0	2.50987
BRD-K68056389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12461
GSE131377_4_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17183
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MMRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569005
EDEM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25915
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28421
GSE214823,GSE214824_4_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
non-small cell lung adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.452
nor10	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
A549_FLLL32_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012718
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62693
BRD-K95213130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86989
PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-gene_id_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11165361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57001
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pneumoconiosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
CMG complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
CDC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57379
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269672
lb4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.62
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8942
BRD-K11823863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18594
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69158240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37308
BRD-K98541397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38028
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17858048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05225
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2779
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Transcription factor TFIIIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
Respiratory epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.368
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.463974
Liver And Intrahepatic Biliary Tract Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65218
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76618080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91193
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3936
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIRT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5436
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SPIN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38419
AD-09-MD49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225068
ANKRD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52542
BRD-A81407814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0036
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94629607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78089
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28341
A549_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138168
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214823,GSE214824_5_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51897928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80685
PMC7248321__F5	PFOCR Pathway Figure Associations 2023	1.0	null
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256473
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC30A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54036
BRD-K45519638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00631
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3921
IGF2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00275622
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
T-98G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.714
BRD-K98601267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14193
BRD-K03057797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66725
CHD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56022
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19501
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00162
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228492
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-48-ZT65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294078
Pancreatic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.89134
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastritis, Atrophic	DisGeNET Gene-Disease Associations	1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548312
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.7381
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17910820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1834
Chromatin organization	Reactome Pathways 2024	1.0	null
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25138450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41506
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00444
5205_MRPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.678808
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18043
BRD-K30963311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05221
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.354
GSE86021_1_v_3_crenolanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58153
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K00744507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29023
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385018
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
OGT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640925
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95806
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRXL2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601227
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
ADRA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22093
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8033
Biliary tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
GSE218060_7_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94014790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97378
BRD-K53223020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13565
GSE203308_7_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Up_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE108500_1_v_0_foxp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322622
A549_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171578
CDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24726
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HSD17B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671818
KEAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0082385
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ANKIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0363
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.91
PSMA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072936
BRD-K87316858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52276
Myc-Max complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
preribosome, large subunit precursor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.664
GSE174498,GSE174500_2_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLDIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09599
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49889
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386878
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_7_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYO3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586239
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
IM95	DepMap CRISPR Gene Dependency	1.0	3.79828
BRD-K85823016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66432
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TXNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1304
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648108
Bile duct carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_29_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
lp1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.082
BRD-K72145393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1015
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-32-EI69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23244
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.76601
FAM86B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00184
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A54490075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57769
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31644794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16224
GSE215086_3_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A55408860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79616
BRD-K91937280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39089
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PDIA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13546
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73330516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23405
UBE2F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592262
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623761
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lb24	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.033
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47963
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.69742
PTTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44844
decreased airway responsiveness	MGI Mouse Phenotype Associations 2023	1.0	null
PNKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08632
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32071534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29901
Bronchial epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.476
NUDT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494493
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.1294
PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_ST-Gene_Symbol_DLX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNGM	DepMap CRISPR Gene Dependency	1.0	2.90027
WM88_SKIN	CCLE Cell Line Proteomics	1.0	2.21138
RELL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06768
MAX::MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6667
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-8.1159
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1596
YC-27-PB87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20568
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195568_1_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47294
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6052
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282435
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2832
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5057
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1137
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6354
BRD-A71880598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03015
CRCGN017_MCF10A.WT.HP_24H:H11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1281
GSE131377_4_v_2_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65552
BRD-K83667863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73148
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K36782804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13124
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K24333636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03406
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211016
BRD-K04701596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59145
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133516_0_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUPT5H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90338
BRD-K66282601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12922
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2455
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6765
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86065
Dmbx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8295
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203237
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27323347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33886
BRD-K92985620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38735
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93227
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1385
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_1_v_9_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
BRD-K22380421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27267
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227722
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3594231-pone.0057799.s001.docx-9-ENSG00000131408_NR1H2	Rummagene Transcription Factor Associations 2026	1.0	null
NUSAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00350315
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.40839
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1299_LUNG	CCLE Cell Line Proteomics	1.0	2.3017
Placental cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
G6PC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487322
BRD-K29242326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21081
K562_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194369
BRD-K83475223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04066
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235002
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217413
RPE1SS48	DepMap CRISPR Gene Dependency	1.0	3.40485
PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22	Rummagene Transcription Factor Associations 2026	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.749024
SMIM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42128
LAMTOR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479201
BRD-K58715359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0388
Trichome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GRIK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00714634
BRD-K55916310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69051
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
chr3_98015083_G_A_b38	GTEx eQTL 2025	1.0	3.99582
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10635555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35888
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE2G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97306
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04233
PRSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455475
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4728380-ncomms10153-s6.xlsx-Pre-ranked_gene_list_MYC_Target-Supplementary_Data_5_GSEA_analysis_of_c-MYC-bound_promoters_in_control_HFF_MYC-ER_cells_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6102
ZGPAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524814
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24766
BRD-K28122619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33763
BRD-K00765599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69364
BRD-K73858940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28821
BRD-K75495990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31111
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mb04	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.087
nucleolus	GO Cellular Component Annotations 2023	1.0	null
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316968
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26165
GSE100464,GSE100465_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206159
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63067
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Renal pyramid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
BRD-K13086002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84196
Taurine dioxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.055
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02683
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DF-84-RT50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209201
BRD-K80851151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7741
BRD-K86463534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38672
BRD-K04650671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0768
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.643
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.50487
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
BRD-K21470524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53879
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97578
BRD-K14673075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10153
BRD-K46701848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31127
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.83435
XA-82-BM12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222253
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95500860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45562
BRD-K19039785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09288
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
BACE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1423
PSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87012
RBMS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597041
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530984
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42412
Ige-Mediated Allergic Asthma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K23533429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94359
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null