association	dataset	threshold value	standardized value
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38081
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Retinal pigment epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.724
CRCGN015_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27955
BRD-K90879242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2536
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.36439
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.0596
BRD-K04087396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12093
BRD-K66655211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61447
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36613
Body Weight	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K14436020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27906
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Retinal ganglion cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.854
SPCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17464
BRD-K78363521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5623
GSE160017,GSE160022_1_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hip Circumference	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K36289678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16294
BRD-A41199690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10672
Autophagosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.666
BRD-K12145385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29929
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2206
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4519778-srep12524-s2.xls-Table_S5-Supplementary_Table_S5_List_of_all_identifed_alternative_transcription_events_betweeb_MDMs_and_IPSDMs_and_in_LPS_response_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.499
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74656131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26041
ha88	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.594
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.17255
Retinal detachment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.655
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.723
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
BRD-K34595206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25321
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2169
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82292
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367088
Endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K12077693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78151
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65124
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64992851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28191
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62007935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17884
chr18_23506161_C_T_b38	GTEx eQTL 2025	1.0	3.25102
CORVET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.517
Diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.449
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.57745
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.153
BRD-K03608799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06204
BRD-K21533599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19621
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_4_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKBR3	DepMap CRISPR Gene Dependency	1.0	4.94135
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225659
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neural retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.644
BRD-K36042673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06123
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65784
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58553
BRD-K79438478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60428
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Proteasome activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.832
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.193
BRD-K31660953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33742
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Impaired Glucose Tolerance	DisGeNET Gene-Phenotype Associations	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Amphisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
BRD-K94344234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01757
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477045
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.4988
BORC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.054
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2342
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7387
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
Secondary Malignant Neoplasm Of Liver	DisGeNET Gene-Disease Associations	1.0	null
GSE149903_0_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A30962679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23109
FBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47585
BRD-K60296400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09376
BRD-A80723361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50061
Adenomatous Polyps	DisGeNET Gene-Disease Associations	1.0	null
Vitreous chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.567
BRD-K05471809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30294
BRD-K78015078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33845
GSE151782_2_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69175109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15809
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34363290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07623
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K26161397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36516
BRD-K74879991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13266
PMC9091241-41598_2022_11720_MOESM2_ESM.docx-89-CREB1_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
CRISPLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6576
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04437
BRD-K97339945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96722
TRAPP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.077
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K26376097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79214
PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296674
Photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.962
BRD-K17293545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58493
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39399
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97921950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33814
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63970901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43124
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03512
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.14565
BRD-K23610423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.297
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16496140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14465
Vacuolar HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.226
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.30027
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9413
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BLOC-3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.335
CRCGN015_MCF10A_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46074
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-14.71
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.35612
BRD-K80888333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23211
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Microglial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
RNPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02499
rab9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4221
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20672
Central Nervous System Lesion	DisGeNET Gene-Disease Associations	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8736
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344235
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.5557
BRD-K19662956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41025
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
Late endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.703
Embryonic brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4184
HCC1954	DepMap CRISPR Gene Dependency	1.0	3.17868
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176093_0_v_1_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8442
POMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26422
BRD-K56881825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6702
BRD-K89687419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54665
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00165
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221726
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.674
GSE157050,GSE157051_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Embryonic hippocampal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.03
BRD-K87193132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64194
PSMA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0112002
BRD-K44224150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26536
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K29614616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27463
Multiple Myeloma	DisGeNET Gene-Disease Associations	1.0	null
SKRC20	DepMap CRISPR Gene Dependency	1.0	4.16417
BRD-K49573242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08221
BRD-K98018160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63186
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUSA	DepMap CRISPR Gene Dependency	1.0	2.71758
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37
GSE100102_4_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Metastatic Melanoma	DisGeNET Gene-Disease Associations	1.0	null
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K01334037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65298
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12784616-12711_2025_1028_MOESM2_ESM.xlsx-TableS7-Table_S7_Summary_of_significant_MR_associations_in_milk_cells_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87654551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03449
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H103	DepMap CRISPR Gene Dependency	1.0	2.37107
PMC3729750-NIHMS493477-supplement-1.doc-9-Supplementary_Table_10a_Comparison_of_gene_expression_profiles_between_cases_with_activated_SETBP1_high_expression_and_mutation_and_SETBP1_lower_expression_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21565
BRD-K16109630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26768
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55367
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71755
BRD-K68009914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91697
ERCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1559
Mueller cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.688
BRD-K57155690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20982
Syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
K562_SRT2104_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163789
SNU1033	DepMap CRISPR Gene Dependency	1.0	3.52239
Photoreceptor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.773
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6864
GSE168676_0_v_1_dach1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34370545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21311
Macular retinal edema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
endosome membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K08416880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56936
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06974027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26102
SUPV3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77346
MYLA	DepMap CRISPR Gene Dependency	1.0	7.45489
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8363
CRCGN013_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30811
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94580242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28097
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46757
BRD-K72694472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62506
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMRTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0689
BRD-K54814515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02126
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_6_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03775
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254821
U118MG	DepMap CRISPR Gene Dependency	1.0	2.09711
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02106
WDR55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30537
SNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06882
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9958
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2887
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
Tendon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.662221
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89937
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.718
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1133
BRD-K99074976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31037
BRD-K13289658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57962
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
BRD-K70158474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12975
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.718
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.72457
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
LPAR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02179
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTF3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63242
BRD-K40300525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20075
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6207
BRD-K19579217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08819
UMUC11	DepMap CRISPR Gene Dependency	1.0	2.29155
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ML-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
Pancreatic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
RGC-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
BRD-K19575490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1083
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2016
H4C7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14757
RPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28041
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130690,GSE130692_2_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95740363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12737
Colonic cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K59847773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05653
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279287
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K14359942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10813
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FEV1	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09919
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68925
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.546935
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.471
KMS-11/TKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
BRD-K17886576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29164
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53127431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52443
HCC38	DepMap CRISPR Gene Dependency	1.0	2.19271
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69089961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68647
BRD-K69751974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03069
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.732
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433659
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Myelin sheath	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.0257
Childhood Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retinal pigment epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.482
TGFBRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02532
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Waist-Hip Ratio	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K97470305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.535
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24545
BRD-K57778236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0667
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A43575461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71186
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58565
BRD-K42496940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53113
BRD-K79352289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74216
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46089
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.535
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.60962
BT12	DepMap CRISPR Gene Dependency	1.0	2.08178
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05639
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3962
BRD-K26291134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06387
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.759931
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57128
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2151
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical layer of collagen and cuticulin-based cuticle extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
BRD-K77181307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29364
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98631
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01875
CRCGN012_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58905
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.901
BRD-K50593511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78683
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63937112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24519
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.39512
GSE112995,GSE132079_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Retinal edema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.526
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.93808
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52657580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66179
GSE247862,GSE247863_0_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.32266
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1064
BRD-A28219573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1351
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3532
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.614
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.1804
BRD-K98437821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34519
BRD-A80968824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66213
BRD-K78625574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0557
Atherosclerosis	DisGeNET Gene-Disease Associations	1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Atherothrombosis	DisGeNET Gene-Disease Associations	1.0	null
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48634117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37281
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333986
FTH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06857
HUH6_LIVER	CCLE Cell Line Proteomics	1.0	2.75669
BRD-K51956957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27928
GSE178560_0_v_1_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.15364
HLCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56258
BRD-A39193201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05356
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
MAGOHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21117
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Horizontal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.224
Obesity	DisGeNET Gene-Disease Associations	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01148617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21195
GSE57871_8_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K18768055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55671
BRD-K02881560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16977
FAM124B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29935
BRD-K58219783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47703
GSE100102_4_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20454972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33319
CRCGN014_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78255
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_upregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08416835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55688
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.66
GSE200352_5_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SYNGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76218
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Procambium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.551
ABC1_LUNG	CCLE Cell Line Proteomics	1.0	2.78445
Pancreatitis	DisGeNET Gene-Disease Associations	1.0	null
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04491
BRD-K10704442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03452
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99485242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05808
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13373
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0517
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25295
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31801624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17328
Myocardial Infarction, Stroke	DisGeNET Gene-Disease Associations	1.0	null
BMI (adjusted for smoking behaviour)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
R3HCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23995
GSE189772,GSE189773_0_v_5_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tendon sheath	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17063694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1415
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retinal ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.592
Waist circumference	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
BRD-K09366011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01461
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6952
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7177
BRD-K84794783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59006
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07028
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.824653
BRD-K67348226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71694
Lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PANC0203	DepMap CRISPR Gene Dependency	1.0	3.50623
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28668
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6801
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.5511
BRD-K80895505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12164
BRD-K61287439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58511
PELI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01531
BRD-K18087940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55667
BRD-K61491580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49266
BV-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.137
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Erosion	DisGeNET Gene-Disease Associations	1.0	null
BRD-K37848780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31954
CRCGN016_MCF10A.WT.HP_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31916
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66222602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25464
ACAD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03574
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.26483
BRD-K46085646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00152
Vitreous humor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.584
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1303
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.52203
Metastatic Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.37699
BRD-K48113109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57518
GSE179974_3_v_2_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Annuli extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02371
KLHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24773
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86399
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39571490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21743
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3261
BRD-K17885598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20491
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44003352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54263
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PEDS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18433
BRD-K18527484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9634
PSPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64266
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77808555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06977
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401964
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1648
BRD-K93752373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70504
Inner nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.699
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.74965
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BLOC-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.738
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93304
BRD-K46445956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16398
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uveal Melanoma	DisGeNET Gene-Disease Associations	1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Alcohol consumption (drinks per week)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
BRD-K81314458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51591
CH157MN	DepMap CRISPR Gene Dependency	1.0	2.94512
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	47.6034
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52838
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3534
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35961
BRD-K02691653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67957
Bile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00583
Pancreatic Ductal Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7028
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.614
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64229
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K97377031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20216
BRD-K08389897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00794
Retinal microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.622
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38119
BRD-K36941678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0175
BRD-K27121064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44927
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75252192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28087
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81322049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26729
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260073
chr18_23529286_T_C_b38	GTEx eQTL 2025	1.0	1.79617
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TR-146 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
KMRC1_KIDNEY	CCLE Cell Line Proteomics	1.0	3.12126
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67209
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4519
GCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92297
Mon1-Ccz1 complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K08075712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15914
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K23533429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09732
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223609,GSE223610_0_v_2_kdm6a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.501
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59658487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28895
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56417082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27928
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01614
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.407
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5129
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.771
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intraductal Papillary Mucinous Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53953065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61442
BRD-K58743752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28691
SNU840	DepMap CRISPR Gene Dependency	1.0	5.10022
GSE211286_4_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cloned cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.595
BRD-K44401972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01731
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91513229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50216
BRD-K99022424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25858
SLC25A29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0959
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2523
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54931539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09855
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01185
Proliferative diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.466
GSE70883,GSE71179_0_v_1_pbx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTDNEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23412
Aloof	DisGeNET Gene-Disease Associations	1.0	null
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00365
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328914
PHF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0416
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Optic cup	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.112
BRD-K92140823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83952
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.10822
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr18_23544981_C_G_b38	GTEx eQTL 2025	1.0	1.8669
BRD-K76543697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81301
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
MKN45_STOMACH	CCLE Cell Line Proteomics	1.0	6.21743
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92849826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48944
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08115
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90756713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32097
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4288
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_5_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01624
BRD-A52729710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2908
BRD-K21955896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18878
BRD-K63093217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27051
BRD-K26026745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09471
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0336
LEMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15377
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.408
GPR143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00168
BRD-K52339742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04231
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41694
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.92019
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_7_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0788
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275473
496100444_HIP_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40092
BRD-K77890526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50894
BRD-K01463939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2669
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.88843
GSE191015_1_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05501176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35978
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.077
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Protein levels in obesity	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26591929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.419
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K91503401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30912
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
CRCGN015_HEPG2_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1714
BRD-K24585433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09864
TTC549	DepMap CRISPR Gene Dependency	1.0	2.43169
BRD-K21535473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13225
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76755163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2308
BRD-K03923461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21396
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16469
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04047
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280147
Scolopidium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.087
CRCGN014_HEPG2_3H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94253
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280466
ANGPTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22031
BRD-K86966177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10866
GSE228619_0_v_1_cdh11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98772859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31141
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
BRD-K49681465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35057
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vesicle tethering complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.514
regulation of autophagy	GO Biological Process Annotations 2023	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269144
BRD-K96834095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28232
BRD-K87159315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76841
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32019201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62057
BRD-K70042405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46743
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09085
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.799625
BRD-K68364310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45192
BRD-K08036779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32033
BRD-K74267000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04362
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2023	1.0	null
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03668
BRD-K07557785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32721
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukostasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.796
PSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14956
BRD-K57075511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51543
BRD-K92372829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03475
GSE250518_0_v_2_trpm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15038
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.03725
Carcinoma Of Bladder	DisGeNET Gene-Disease Associations	1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	61.4678
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45693
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32731
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75845970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10146
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.486633
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36075
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	63.9933
BRD-K29549246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14055
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229965
BRD-K77221872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12046
Hand grip strength	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A08820802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00741
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2607
GSE149903_3_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HBS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22837
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.49148
BRD-K96510191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11851
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mon1-Ccz1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.52
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lysosomal membrane	GO Cellular Component Annotations 2023	1.0	null
late endosome membrane	GO Cellular Component Annotations 2023	1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3808
BRD-K27911943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32473
GSE114272_0_v_1_clk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49875
BRD-A43409498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30979
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K56183302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63068
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278291
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49558
ST14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28739
BRD-K22564762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68637
BRD-K01899298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55317
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82648
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BLOC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.066
CRCGN013_HEPG2_24H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06651
MRTO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0827
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K18828858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05861
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2854
Bipolar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
BRD-K53647637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75589
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50113
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Weight	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
T3M3	DepMap CRISPR Gene Dependency	1.0	4.37016
BRD-K70237115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26063
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Progression Of Prostate Cancer	DisGeNET Gene-Disease Associations	1.0	null
BRD-K75853175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20148
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80443236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68721
BRD-K18763924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27386
MSTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12651
MAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57907
RTN4IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68233
BRD-A43076080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40093
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5169
BRD-A46631350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00271
PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93148720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22148
BRD-K90264208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9951
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.941
Anophthalmia And Pulmonary Hypoplasia	DisGeNET Gene-Disease Associations	1.0	null
Cerebral Palsy	DisGeNET Gene-Disease Associations	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRABP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09159
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
Benign Prostatic Hyperplasia	DisGeNET Gene-Disease Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58415
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31034
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Capillary pericyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDC42EP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19952
HS695T	DepMap CRISPR Gene Dependency	1.0	4.64338
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12480102-41525_2025_515_MOESM2_ESM.xlsx-ST12-Unnamed_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56224420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45294
BRD-K98595604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09146
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73523821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01074
C2BBE1	DepMap CRISPR Gene Dependency	1.0	2.0773
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAKI1	DepMap CRISPR Gene Dependency	1.0	2.60794
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99078335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28847
ARHGEF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31657
K562_Cerdulatinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016306
Abdominal obesity-metabolic syndrome 1	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27525139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72368
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.762232
GSE205788_0_v_1_gfap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126219_0_v_1_haloperidol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
MON	DepMap CRISPR Gene Dependency	1.0	9.13752
CRCGN015_MCF10A.TP53.M_24H:F07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08365
BRD-K63984483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18006
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3244
BRD-K88812688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0584
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.0562
NDRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38972
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06315
BRD-K87666020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22705
BRD-K97013733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21141
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.503
BRD-K93624320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09534
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19852577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43483
GSE149903_6_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PNLDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04912
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63908
PKHD1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677443
BRD-K93283197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15822
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8297
BRD-K31407552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21476
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MM160113	DepMap CRISPR Gene Dependency	1.0	2.94711
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79631534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04849
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Adult Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K82683018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32193
Choroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100545_HIP_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26552
BRD-K60744874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5544
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.0
ARPE-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.175
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	238.72
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDC25B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66565
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13927
GSE200673,GSE200691_2_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20184768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09669
RAB6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35972
BRD-K48557872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42421
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30781
BRD-K38791044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2615
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51955
Optic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
Glioma	DisGeNET Gene-Disease Associations	1.0	null
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE238018_3_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.717
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158438_4_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18352607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4454
GSE193624_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lens epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410903
LI7	DepMap CRISPR Gene Dependency	1.0	2.19681
Smoking	DisGeNET Gene-Phenotype Associations	1.0	null
CCDC152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61193
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.891
Sphingolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
BRD-K40252598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28156
BRD-A70167453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05435
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1863
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90331
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9253
BRD-K98169006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05155
Inner plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoproteome_AKT2_KD_vs_SCR-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13007223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43279
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5346
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Esophageal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
GSE127790_11_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74611044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85427
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301342
IVNS1ABP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28959
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.59852
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46048
BRD-K72770355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20897
Thyroid	GTEx Tissue Gene Expression Profiles 2023	1.0	5.04589
GSE142210_11_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7083
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
LN229_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.15295
BRD-K66993610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26439
BRD-K67734449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18108
GSE190186,GSE190188_8_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67638302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16759
BRD-K93884191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08704
BRD-K08311368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41706
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PTPN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21274
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr18_23502353_T_C_b38	GTEx eQTL 2025	1.0	1.7363
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86253
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96566
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19164
Mueller cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	3.031
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.14245
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Amacrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.271
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81139344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06719
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92927161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48972
SS18L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51135
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.732
COQ8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23713
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-E2F1_UP_V1_DN-Gene_name_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of autophagy	GO Biological Process Annotations 2025	1.0	null
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61621900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27227
BRD-K28694162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01346
ZYG11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2885
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HUNS1	DepMap CRISPR Gene Dependency	1.0	3.18107
BRD-K40809590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3553
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2972
GARP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.178
CRCGN012_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40704
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.19446
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62942
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07011015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2972
BRD-K63716942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42145
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54023716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77056
COV434	DepMap CRISPR Gene Dependency	1.0	2.35912
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174383_2_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68401280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06808
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39692099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42302
BRD-K28299335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3487
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MMS22L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02277
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06981
Vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.15265
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
496100619_HIP_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.044
BRD-K27011412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49281
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54374
Retinopathy of prematurity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344856
Degeneration of macula and posterior pole	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
Skin Carcinogenesis	DisGeNET Gene-Disease Associations	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90956468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05352
FAM199X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23568
chr18_23507567_C_T_b38	GTEx eQTL 2025	1.0	1.10933
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1645
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08885
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9279
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124410_3_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86942117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42933
RPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38307
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98318
CRCGN015_HEPG2_48H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44371
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39449072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85044
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAFAH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50214
BRD-K78192025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90545
BRD-K33272704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68574
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFATC2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58713
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05005
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8163
CRCGN014_HEPG2_3H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03022
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
BRD-K08927194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10613
BRD-K34498495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17754
BRD-K56739005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1762
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
8505C_THYROID	CCLE Cell Line Proteomics	1.0	4.48314
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_8_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_6_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.4375
BRD-A89983325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53269
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3774
BRD-K76487707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49268
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-toNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32943057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12351
Biliary Tract Cancer	DisGeNET Gene-Disease Associations	1.0	null
Abdominal obesity-metabolic syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
BRD-K17285268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53748
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.422
PMC11225427-13058_2024_1861_MOESM2_ESM.xlsx-Supplemental_Table_S4-Supp_Table_S4_AR_mediated_PGx-eQTL_genes_and_associated_with_all_GWAS_traits_from_GWAS_catalog_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
Sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.306
BRD-K73574487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43201
BRD-K85044233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03079
BRD-K68758594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15065
LDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58831
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16727544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3573
Synovial tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.45181
GSE247862,GSE247863_2_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65135171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45047
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.129
TPX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29725
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
BRD-K14166090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05193
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2607
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4956
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.788
GSE146074_9_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48671
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
RRAGD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18177
HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.603
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10857
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DGKI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00474132
Monocyte percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4842
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5583
BRD-K84362145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65652
CRCGN015_MCF10A_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14808
ACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62961
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02865
BRD-K38120474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82811
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.28195
BRD-K25540102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12076
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02006
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3084
Optic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.452
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
Liver Cirrhosis	DisGeNET Gene-Disease Associations	1.0	null
HCC1395	DepMap CRISPR Gene Dependency	1.0	6.78932
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8977
HUPT3_PANCREAS	CCLE Cell Line Proteomics	1.0	2.69232
Secondary Malignant Neoplasm Of Bone	DisGeNET Gene-Disease Associations	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A45349889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15412
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95218317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09074
BRD-K41999717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56092
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58303
PMC11912599-13059_2025_3531_MOESM4_ESM.xlsx-SREBF2_KO_vs_vector-symbol_SREBF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443287
Ulcerative Colitis	DisGeNET Gene-Disease Associations	1.0	null
Posterior amorphous corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
Childhood Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.19351
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33503286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1826
BRD-K85232515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58295
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.3225
BRD-K15499806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22764
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.56868
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70198986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01655
BRD-K74963702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43048
DCP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19754
GSE240027,GSE240030_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50342
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51955
CCDC74A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52627
BRD-K37919122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09505
BRD-K98271666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83575
BRD-K86298765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56484
BRD-K45400577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68653
BRD-K09160804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45225
BRD-K16518464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01999
Metastasis From Malignant Tumor Of Prostate	DisGeNET Gene-Disease Associations	1.0	null
BRD-K49039223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77638
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6626
BRD-K58277621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12516
Cancer Cachexia	DisGeNET Gene-Disease Associations	1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0845
PANC0203_PANCREAS	CCLE Cell Line Proteomics	1.0	3.61075
BRD-K90951880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23748
BRD-K88836117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52412
Intelligence	DisGeNET Gene-Phenotype Associations	1.0	null
GSE158738_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.09907
SUDHL8	DepMap CRISPR Gene Dependency	1.0	3.5286
Ganglion cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.868
MIO-M1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.356
BRD-K70940767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50989
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70169
BRD-K88996418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20914
BRD-K65423474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93572
BRD-K97569931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72207
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Coinfection	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.46835
Lung function (FVC)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.11549
Mental Deterioration	DisGeNET Gene-Phenotype Associations	1.0	null
Body Mass Index	DisGeNET Gene-Phenotype Associations	1.0	null
Barrett Esophagus	DisGeNET Gene-Disease Associations	1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2025	1.0	null
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394736
BRD-K93561942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16213
CRCGN015_HEPG2_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48147
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16536
BRD-K39858575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.055
lysosomal membrane	GO Cellular Component Annotations 2025	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Blood 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	3.09313
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69131
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56256
BRD-K28349636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39391
STAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27243
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.460322
Autosomal dominant disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
661W cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.14
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.7301
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60627
Phosphatidylinositol 3-kinase complex, class III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.726
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.88411
BRD-K88670720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06707
Bitter alcoholic beverage consumption	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neovascular inflammatory vitreoretinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15879
BRD-K13572796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32984
BRD-K98682310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32893
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.21974
BRD-K94018786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36495
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.51339
TE6_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	4.79151
lysosome	GO Cellular Component Annotations 2023	1.0	null
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1007
BRD-K87808996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50864
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08035
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
endosome membrane	GO Cellular Component Annotations 2023	1.0	null
chr18_23582324_C_T_b38	GTEx eQTL 2025	1.0	1.33943
BRD-K06091213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82115
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostatic Adenoma	DisGeNET Gene-Disease Associations	1.0	null
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01311880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19185
Mild Cognitive Disorder	DisGeNET Gene-Disease Associations	1.0	null
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23374
CRCGN015_HEPG2_48H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12137
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3398
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7634
HCC1395_BREAST	CCLE Cell Line Proteomics	1.0	3.87861
b19	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
GTEx Blood 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	13.813
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GOLGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09915
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37727
BRD-K97731768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0426
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175496
CRCGN016_MCF10A.TP53.M_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.89513
MRPL40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03227
Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
GSE169155_3_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
late endosome membrane	GO Cellular Component Annotations 2025	1.0	null
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56394
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.14612
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14405
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99736408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81695
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30625
OLIG2-29049317-MOUSE-SPINALCORD	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K24191730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14135
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.727
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12429
BRD-K93488589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04662
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ciliary body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6235
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06480376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51617
GSE179693,GSE179694_4_v_2_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.55032
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16364953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18616
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP5MJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0947
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402312
BRD-K40318276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1392
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Recurrent Tumor	DisGeNET Gene-Phenotype Associations	1.0	null
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25788
BRD-K33752391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92185
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98312
BRD-K41311678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22553
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.614
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0573
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9675
BRD-K47063692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35648
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13269
Proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K79877849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40665
lysosome	GO Cellular Component Annotations 2025	1.0	null
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE241792_3_v_1_elf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Late endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K76193544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77316
GINS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00358852
BRD-K04143779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41226
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94301203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82062
BRD-K84974041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42689
GSE185519_6_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.42632
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6486
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.849
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27298
BRD-K75857911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24912
BRD-K97688756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47228
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35991
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8851
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37285
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47886441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09564
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Early endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.777
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
APTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03628
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5244
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
Phagocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.30979
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_24-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.83185
NDUFA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71321
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
BRD-K14681218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28562
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1252
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487678
BRD-K13279882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42328
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
BRD-A19829191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3107
BRD-K28785305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13046
Retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.425
BRD-K79370456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50386
HCC1143	DepMap CRISPR Gene Dependency	1.0	2.71143
BRD-K84401063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08832
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23793049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06305
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4859
COLO800	DepMap CRISPR Gene Dependency	1.0	2.16734
BRD-K52924481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23383
Tuberculosis	DisGeNET Gene-Disease Associations	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	4.91019
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60018
PMC12480102-41525_2025_515_MOESM2_ESM.xlsx-ST12-Unnamed_3_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59865704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54295
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
Walking pace	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.05229
BRD-K46121327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96638
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.72125
BRD-A07861932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00472
BRD-K47536398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03256
BRD-K19608864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26413
BRD-K11577431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17895
Solitary Pulmonary Nodule	DisGeNET Gene-Disease Associations	1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Posterior chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
BRD-K43909206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07081
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.498
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6109
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0698
Endolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.668
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3016
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.599055
Dsl1/NZR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
BRD-K51342021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47412
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61557
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154464_0_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232812
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02530287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2487
GSE114992,GSE114993_0_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0722
Lewy Body Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hormone Refractory Prostate Cancer	DisGeNET Gene-Disease Associations	1.0	null
UTP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25922
M040416	DepMap CRISPR Gene Dependency	1.0	5.85767
BRD-K69109808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44456
BRD-K54332480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76633
CDC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10878
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19542
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52218
BRD-K52492854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0937
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.3485
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100653_PCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37193
MB1	DepMap CRISPR Gene Dependency	1.0	2.65986
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
Y-79 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
Cardiomyoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94744294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43378
Sto	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.8886
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0485
CCK81	DepMap CRISPR Gene Dependency	1.0	5.78697
BRD-K65860773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17461
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S100A16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13646
BRD-K58696904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56378
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17372597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0296
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40893
aklomide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21914
Lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K84118789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10957
BRD-K47572485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09054
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21759602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01495
Retinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.574
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28043
Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4897
GSE149366_1_v_0_sulconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF778	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43964
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0634
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Superficial Ulcer	DisGeNET Gene-Disease Associations	1.0	null
GULP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06851
BRD-A36938160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41708
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
GSE77795_0_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36397874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58878
BRD-K11741103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61477
Mon1-Ccz1 complex	GO Cellular Component Annotations 2025	1.0	null
Toxoplasmosis	DisGeNET Gene-Disease Associations	1.0	null
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMGB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47523
PHTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41712
BRD-K05041765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36694
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70118
GSE228106_0_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06808
PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoprot_AKT1_AKT2_KD_vs_SCR-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67941637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31532
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290002
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09526
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233548_3_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4373
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329883
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8368
Intelligence (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
BRD-K12226398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37435
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.37281
Lytic vacuole membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Bile Duct Proliferation	DisGeNET Gene-Disease Associations	1.0	null
High-Grade Prostatic Intraepithelial Neoplasia	DisGeNET Gene-Disease Associations	1.0	null
Early Gastric Cancer	DisGeNET Gene-Disease Associations	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.7588
BRD-A19962819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08333
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31001397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9364
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.451213
JP-4-043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44708
BRD-K08212599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72588
BRD-K58971526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13687
BRD-K62682892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58301
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85843964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63429
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2361
Gastrointestinal cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K24984327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31821
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6249
RAB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17893
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80602847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08352
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37404
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2079
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0626
CRCGN015_MCF10A.TP53.M_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0761
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309995
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
BRD-K54510565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01827
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9962
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248858_1_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100629_HIP_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6638
BAMBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75267
BRD-K86923998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37707
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00601
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
BRD-K38017028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01241
GSE217685_0_v_1_ddx20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.90434
WBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19769
Retinal cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209249
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68858233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40915
regulation of cellular catabolic process	GO Biological Process Annotations 2023	1.0	null
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
BRD-K17893805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46587
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132759_4_v_2_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29011844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05325
BRD-K20072174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37334
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.17987
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.29
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GUF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24455
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90313630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3473
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adrenal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.248
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.54612
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08046
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Outer plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.41
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.057
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363726
BRD-K44133102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39805
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21285405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41907
BRD-K30019337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46572
BRD-K72872864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6959
Hip circumference	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
M1 melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
NETO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15377
CCK81_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.0845
BRD-K81592842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81124
BRD-K02053819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28126
BRD-K11554989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14708
GSE189683_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUDHL5	DepMap CRISPR Gene Dependency	1.0	4.30244
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Mlg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
NCIH1792_LUNG	CCLE Cell Line Proteomics	1.0	7.48982
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69453
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.420482
BRD-K41009039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06774
regulation of catabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K73678117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43532
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50894381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19515
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87175
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1312
GSE160442,GSE160444_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.11552
MUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03447
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27776
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.05664
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398964
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57331
BRD-K95105171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28385
Cachexia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K47865468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04273
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23098
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.114
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1422
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.422
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.85693
ZNF248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41437
BRD-K12517207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47556
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08826
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDCA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39502
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1731
BRD-K13265046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20943
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24572
PMC8190596-mmc2.xlsx-ETV6_mut-ETV6_mut_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.66492
HNRNPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04014
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5095
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.14035
BRD-K15775306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43792
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02946901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34873
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49664555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16371
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5097
BRD-K71876816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50533
CRCGN016_MCF10A.WT.HP_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20095
Niemann-Pick disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
BRD-K56884305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26459
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68757
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11859767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22345
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HT55	DepMap CRISPR Gene Dependency	1.0	5.43242
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8076
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.73306
BRD-K38189984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09136
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-IRF1-HIT_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mrsa - Methicillin Resistant Staphylococcus Aureus Infection	DisGeNET Gene-Disease Associations	1.0	null
KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.71418
Poultry consumption	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
GSE190076_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93777
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08745
Background diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23748
SMARCB1-deficient renal medullary carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.191
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288346
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05220907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31078
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02065805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11232
BRD-K22701871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40566
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0153
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
late endosome	GO Cellular Component Annotations 2025	1.0	null
Age related macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
BRD-K48780709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21809
BRD-K68328788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34907
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.628
GSE190235_3_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25200031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07983
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-E2F1_UP_V1_DN-Ensemble_gene_ID_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53643174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14471
BRD-K50599016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05501
rMC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.952
Retinal ganglion cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.036
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1706
BRD-K30462643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12389
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66575
CHAF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46192
RBM48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34538
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSMB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00758881
Anorexia	DisGeNET Gene-Disease Associations	1.0	null
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0834
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93990956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01378
BRD-K95385525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24114
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9282
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63909265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43724
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HCC2218_BREAST	CCLE Cell Line Proteomics	1.0	2.43198
Retinal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66577743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18058
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8851354-Table_6.xlsx-Ruxolitinib_reg_STAT3-bound-Supplementary_Table_6_Genes_regulated_by_ruxolitinib_that_are_STAT3_targets_in_at_least_two_cell_lines_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09295
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241854
BRD-K33497830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35469
BRD-A90289676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51532
BRD-K28399883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40088
BRD-K12473406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86327
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12750296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26235
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12164972-FSB2-39-e70689-s001.pdf-47-TEAD1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Retinal pigment epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.885
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76225
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233448
BRD-K12492021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4465
BRD-K77519898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25934
BRD-K15188108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11039
BRD-K63375777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79582
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.30115
BRD-K23749313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02498
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lysosomal HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.36
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K15098674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21701
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Crown gall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
Endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.24
BRD-K25423143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38919
Extensively Drug-Resistant Tuberculosis	DisGeNET Gene-Phenotype Associations	1.0	null
TTC709	DepMap CRISPR Gene Dependency	1.0	3.50829
Impaired Cognition	DisGeNET Gene-Disease Associations	1.0	null
BRD-K18117162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85111
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.75476
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.58921
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50936
BRD-K58944125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5934
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24345
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78218
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.23446
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.78195
GSE240896,GSE240899_10_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0263
BRD-K26709432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29379
CRCGN009_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15002
BRD-K68333644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27109
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22651517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25641
PMC7806814-41598_2020_80145_MOESM3_ESM.xlsx-CombinedResults_TreatbySexMainE-Supplementary_Table_S2_Genes_with_significant_FDR_0_05_sex_by_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5771
BRD-K85055578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17704
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Collagen and cuticulin-based cuticle extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
GSE157594_5_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86448296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17641
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3021
CRCGN015_HEPG2_48H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61196
BRD-K27294633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28609
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
late endosome	GO Cellular Component Annotations 2023	1.0	null
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82591
BRD-K45271289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16533
OVCA-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
BRD-K97946004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45156
GSE213996_1_v_0_fhl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.614
BRD-K10146653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08875
Atrial appendage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
GSE122067_3_v_0_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79523827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74256
PMC10823279-CAS-115-283-s001.xlsx-Table_S5-Table_S5_List_of_188_genes_particularly_up-regulated_by_AR_in_AILNCaP14_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160246_2_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26200833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38264
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20652
PVR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61111
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68073004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14659
BRD-K10943878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57039
Diabetic macular edema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20549184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40566
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5405
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55977
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96475
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5093
PMC10974709-CAM4-13-e6994-s003.xlsx-IRF1_target_gene-Unnamed_2_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
Macular holes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.44
BRD-K16754572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15743
BRD-K29143088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13886
Vitreous disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
oaw28	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0018
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
NGP	DepMap CRISPR Gene Dependency	1.0	4.05724
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04611090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3698
JEG3	DepMap CRISPR Gene Dependency	1.0	3.19253
Outer nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.635
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0108
BRD-K78886448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36121
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94637
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172016_2_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K37285826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69153
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.981
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.338
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SW1463	DepMap CRISPR Gene Dependency	1.0	7.94149
BRD-K61909412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20664
GRIK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490769
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.715366
PMC12103066-FEBS-292-2688-s001.pdf-208-SOX12_SOX12	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4412
A172	DepMap CRISPR Gene Dependency	1.0	2.56946
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.234
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_1_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19066553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28208
BRD-K94921631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09358
BRD-K64474460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69416
BRD-K84821804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30702
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328285
VCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24867
BRD-K06790927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80374
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1434
BRD-K87343552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22156
Late endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.0635
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88070373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68665
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184135
BRD-K92806245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03053
BRD-K57784254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47171
BRD-K10148216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65931
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SDF2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75563
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6137
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2671
Wart	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.53319
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24416
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Glial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.81
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4027
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42392
SNU1041	DepMap CRISPR Gene Dependency	1.0	7.9584
Tuber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.728
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11955568-41467_2025_57429_MOESM9_ESM.xlsx-Data_S7-JUN_OIS_Martinez2020_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Retinoblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
Synovium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23614490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51174
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	60.7909
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321681
BRD-K11566982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07753
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71377
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12823
BRD-K00628863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24283
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214393
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5266
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50173
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6514
Cleft Palate	DisGeNET Gene-Disease Associations	1.0	null
SUM149PT	DepMap CRISPR Gene Dependency	1.0	2.27696
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239492
BRD-K62708569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99788
BRD-K32854540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01943
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418183
H2BC12L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7595
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
C2orf81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44752
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61075
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.91065
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1428
AGS	DepMap CRISPR Gene Dependency	1.0	4.48371
SW1417_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.32042
BRD-K14567490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25745
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50058129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11683
CRCGN017_MCF10A.TP53.M_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35444
BRD-K91683342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26774
BRD-K62536891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03362
PMC10591418-12711_2023_849_MOESM11_ESM.xls-AA_5W_vs_LS_5W-gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47783463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32438
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88255
GSE120612_6_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5932
NCIH2887	DepMap CRISPR Gene Dependency	1.0	2.12427
BRD-K26351062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94447
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199034_1_v_2_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252229
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.398
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15331
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.94
BRD-K75989234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14019
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27914478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07613
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D2REFED4h_641_AR-D-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.273
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29684
Cirrhosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K91810283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28187
BRD-K07602825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22116
BRD-K69520171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44821
ZNF429	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11882