association	dataset	threshold value	standardized value
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38997
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28484
Bestatin (hydrochloride)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155199
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09547
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67184
Anemia	CTD Gene-Disease Associations	1.0	1.1862
Osteoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
BRD-K12925598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14205
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.850999
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51707293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35143
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042249
placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02555
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97839095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33986
heart	GTEx Tissue Gene Expression Profiles	-1.0	-1.14018
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08675
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.90183
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8325-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140792
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30973947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10102
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04895
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.865819
hsa-miR-624	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59185421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99972
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18681
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEY	DepMap CRISPR Gene Dependency	1.0	5.55507
BRD-K67817697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25214
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-548t	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24402
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14386
GSE149035_1_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129023
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876084
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bafetinib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.52
Edema	CTD Gene-Disease Associations	1.0	1.16203
Lung adenocarcinoma_LUAD_TCGA-38-4627-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10T-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.57933
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Acifran	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
tolbutamide-142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Agranular insular area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09897
GTEX-T5JC-0011-R9A-SM-32PLV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60767
PMC9675280-12950_2022_317_MOESM3_ESM.xlsx-siPAD2_LPS_vs_siCON_LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
GSE223008_0_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24992
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929189
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170654
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.365
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57171
KLF4-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GPR12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553427
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Benzo[a]pyrene	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08861
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863391
LAMP2	Pathway Commons Protein-Protein Interactions	1.0	null
pancreatic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.11044
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05381
Brain Lower Grade Glioma_LGG_TCGA-FG-8187-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Goserelin (acetate)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.015667
TFAP2C_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Voriconazole_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255199
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.950149
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74973
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00471
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.366301
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LU65	DepMap CRISPR Gene Dependency	1.0	5.4426
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10674
myc_20940306_e13dot5_erythroblast_purified_from_liver_gof_mouse_gpl6885_gse18558	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.122361
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-381	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
ZR75_1	BioGPS Cell Line Gene Expression Profiles	1.0	0.989665
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75426080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68374
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_2_TBRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
CBFA2T2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44188
SNARE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.372
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99473
GSE210580_3_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1158
BRD-K80816131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0011
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8022
BRD-K81999794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.552
hsa-miR-224	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Piriform-amygdalar area, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54999
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01692
GSE167886_2_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MIAPACA2	Achilles Cell Line Gene Essentiality Profiles	1.0	1.19624
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854592
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67135
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
Eletriptan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
Spectrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
spleen	HPA Tissue Protein Expression Profiles	1.0	0.908244
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE115363_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
UBE2N	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.915431
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12215
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37062
PTK2	MSigDB Cancer Gene Co-expression Modules	1.0	null
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140149
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.175948
Eccrine sweat gland neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.737
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149325
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GK01981	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
SMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21219
GSE210655_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTF2B	ENCODE Transcription Factor Targets	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.197993
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rimonabant (Hydrochloride)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244399
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189095
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0684
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14175
hsa-miR-4426	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FTC133	CCLE Cell Line Gene Expression Profiles	-1.0	-2.17236
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26428
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CEBPB-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12487
BRD-K88812218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07656
Acute Myeloid Leukemia_LAML_TCGA-AB-2833-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NERF2-26677805-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A60245366_AS-601245_MDAMB231_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPARA-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846255
envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.096867
BRD-K66707905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45113
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0426-SM-3K2AH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900479
SIX5	ENCODE Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31754
BRD-K95864593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1162
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K31977946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.625
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spleen	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.998472
SYK_druginhibition_153_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.00683
hsa-miR-548ah	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058322
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47305
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020902
A549_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012333
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LJI308_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00887263
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.01227
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MECOM	ChEA Transcription Factor Targets	1.0	null
basolateral amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50176
Recycling endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.419
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
16166618-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-FLI1_mod_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15052303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48365
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTNNB1	ChEA Transcription Factor Targets	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	1.0	3.73325
BRD-K51608472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49169
GSE125153_2_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901777
PMC10209342-mmc9.xlsx-UBE2D3_interactors-UBE2D3_interactors_used_for_Venn_Diagrams_from_MINT_STRING_UniProt_IntAct_BioGRID_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K46924722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48658
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16202
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0465
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155031_6_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03770502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97497
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7139-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57426
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949798
TRRAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065914
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZE-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05957
GTEX-REY6-1026-SM-2TF4Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888941
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06128
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Macaque_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_13588_KD_Adamtsl2_SRP341310	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539511
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NCIH508	CCLE Cell Line Gene Expression Profiles	1.0	1.95671
ROR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482245
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.902502
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC30A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56698
BRD-A58767537_afatinib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.933647
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17376
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65977
SERINC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05592
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850894
Agranular insular area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80286
MCF7_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117943
GTEX-R55C-0526-SM-3GIKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944982
GSE155567_2_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191636
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223547
BRD-A16827030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01965
chloroxylenol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26043
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52805
MID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.069
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29458
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922018
nuclear inner membrane	GO Cellular Component Annotations 2015	1.0	null
lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843163
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_19_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00973124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09818
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5909
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979003
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40317
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.374
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-543	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981789
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.82544
JIMT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.959321
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72459
KLF4-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4423-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BICR22	COSMIC Cell Line Gene CNV Profiles	1.0	2.49065
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00373
A549_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145107
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25542
GTEX-RWS6-2426-SM-2XCB9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10529
BRD-K92650579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92412
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9259482-41385_2022_495_MOESM1_ESM.xlsx-S14_neutrophils-Supplemental_Table_13_Neutrophil_cluster1_LPS_vs_LPS_il-1RA_aTNF_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06417
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.849597
GSE201217_2_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896438
GTEX-T8EM-0326-SM-3DB7F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86132
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162625
Fibrosis	CTD Gene-Disease Associations	1.0	1.15492
Lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
C-28/I2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-548c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K31273080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03293
ELK4	ENCODE Transcription Factor Targets	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6073_KD_SUV39H1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.25866
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94539
Prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.059
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04315
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6299
MRPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05458
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lytic vacuole membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SL-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6850_PSMB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.59159
BRD-K19457629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79956
Cataract	DisGeNET Gene-Disease Associations	1.0	null
rab9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.82544
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23361
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224905
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GSE148692,GSE148695_7_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
18535662-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8477
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60759
GSE111247_0_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01129
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.436883
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125279
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28394
GSE196407_1_v_0_fluorouracil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Astrocytoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_11658_KD_PEO1_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.52929
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.38478
GSE190384,GSE190386_0_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29771129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18413
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0895
SP2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05467
REST_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skeletal muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney Tubular Necrosis, Acute	CTD Gene-Disease Associations	1.0	1.09154
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
20068100-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101239_5_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
diphemanil metilsulfate-1994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Muscle Hypertonia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3048
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09609
BRD-K63394284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59998
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863137
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40264
TAL1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.958081
critical	GeneRIF Biological Term Annotations	1.0	null
GSE169571_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ulipristal	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.62
CRCGN011_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48927
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
Short Nose	DisGeNET Gene-Phenotype Associations	1.0	null
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
KNS-42	GDSC Cell Line Gene Expression Profiles	1.0	1.68231
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62722
3557_GSTCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588338
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.910386
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054482
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17237
Montelukast	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.54
NIPSNAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54541
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061545
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42605555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31427
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26113
CREM	ChEA Transcription Factor Targets	1.0	null
BRD-K39206254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49147
hsa-miR-4762-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
SYK_druginhibition_281_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.65076
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
IRF3	ENCODE Transcription Factor Targets	1.0	null
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2023	1.0	null
MCF7_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164427
HRH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054921
Lung adenocarcinoma_LUAD_TCGA-49-6745-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01133
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
ISHIKAWAHERAKLIO02ER	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6481
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231574
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03103
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00373
primary motor cortex (area M1, area 4)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832111
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.11059
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.41527
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18972
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21771537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12808
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-encode-consensu_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
protein autoubiquitination	GO Biological Process Annotations 2023	1.0	null
BRD-K28276275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73891
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161042
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02922
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UTX-26944678-CHIP-SEQ-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
late endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Zileuton_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0186172
MCF7_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151117
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43259
BRD-K20829034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03784
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0089
GSE120413,GSE120447_3_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50000283_PHA-767491_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241645
lateral part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44397
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18075
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.826804
MCF7_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202997
Encorafenib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.99
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166627
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
hsa-miR-376c	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.11046
disease	GWASdb SNP-Disease Associations	1.0	0.043325
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YAP1-20516196-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182137
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35351
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
glioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846481
BRD-K99470595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09383
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35046
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10482
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.733089
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860858
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMRT-22465074-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173275
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54587
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE146865,GSE146866_4_v_3_saracatinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.664613
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.76627
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A23345137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01765
RCOR1	ENCODE Transcription Factor Targets	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51978501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17984
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKOV3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.49048
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81896
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.883618
NCIH2172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55138
BRD-A17120244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87211
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255447
BRD-K69751974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12237
KDM5A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06181307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01144
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01707
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.48921
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP5F1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605416
urinary bladder	HPA Tissue Gene Expression Profiles	1.0	0.933327
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.827284
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01289
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
positive regulation of stress-activated protein kinase signaling cascade	GO Biological Process Annotations 2023	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.72607
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
6856_PSMB7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42537
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61996
MYOG	ENCODE Transcription Factor Targets	1.0	null
astrocytoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Epilepsy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016776
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.86179
GSE160373_8_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SYT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16999
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCOA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8971
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_19_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-607	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
THBD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00671642
Brain Lower Grade Glioma_LGG_TCGA-E1-5303-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Visual Cortex Disorder	DisGeNET Gene-Disease Associations	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
5535_NDUFA2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02089
BRD-K03911650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22284
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06628
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
K562_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156534
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Psychomotor Agitation	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54396
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3652
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-98-5p	MiRTarBase microRNA Targets	1.0	null
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.00472
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09205
r5 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44795
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.89419
REST_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.11639
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121058
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513636
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
urinary bladder	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02734
PBX3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.765578
SLC66A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11704
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_11563_KO_BAX/BAK/BOK_SRP348085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Agranular insular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2777
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
CAL-39	COSMIC Cell Line Gene CNV Profiles	1.0	2.49065
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50763
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169263_1_v_0_armc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MIS12/MIND type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.673
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163984
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97362312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10985
Brimonidine_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021993
Nolatrexed	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.86
BMS 754807	DeepCoverMOA Drug Mechanisms of Action	1.0	0.51
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PROSER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07542
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119592
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02114
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054262
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59083
r6 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33236
Diabetic Neuropathy_Sciatic Nerve_GSE11343	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.49716
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0YX-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21795
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gp2d	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35827
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
neuroblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7647-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FK866	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.13583
BRD-A12166214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30082
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995457
GSE190076_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRF-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41272069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34473
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09251
LU65	CCLE Cell Line Gene CNV Profiles	1.0	2.40753
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SIHA	CCLE Cell Line Gene CNV Profiles	1.0	1.36949
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01042
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.39058
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.915683
KYSE70	CCLE Cell Line Gene Expression Profiles	1.0	1.45566
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587843
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.687044
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14314
BRD-K62682892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71071
BRD-A43331270_niguldipine hydrochloride_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55053106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2181
BICR18	CCLE Cell Line Gene Expression Profiles	1.0	1.64859
MCF7_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213418
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.857272
GTEX-T2IS-1126-SM-4DM6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21937
A549_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014591
hsa-miR-3200-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
TRIM28	ChEA Transcription Factor Targets	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.061825
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54438
Auranofin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0267621
DU4475	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72316
BRD-K16136457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00918
BRD-K15343038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56719
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GRM	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51248
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19759
MYC	ENCODE Transcription Factor Targets	1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.109
GTEX-WFG7-2426-SM-3GIL2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08018
GTEX-XPVG-2826-SM-4B66J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847722
sk-n-sh cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.192196
HCC2218	CCLE Cell Line Gene CNV Profiles	-1.0	-2.53254
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Intestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.891822
BRD-K59606563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09339
t55-gastrocnemius_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.33748
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.42091
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47212522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48528
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15085
BRD-K61621900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2559
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GMS-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SALL4	ChEA Transcription Factor Targets	1.0	null
SARS-BatSRBD_60Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.48014
BRD-A24396574_celastrol_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43979194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25335
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841086
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159354
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19036130-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227698_5_v_0_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2023	1.0	null
Sarcoma_SARC_TCGA-DX-A3U8-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K67035256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01442
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06998
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
para-abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54883
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19505
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
lacking	GeneRIF Biological Term Annotations	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210885_0_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Coronary Artery Disease	DisGeNET Gene-Disease Associations	1.0	null
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45606
ERA-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57293986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35202
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05251963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11632
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69854611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21455
Vismodegib_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0278866
D-3263	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27591
skmel30	HPA Cell Line Gene Expression Profiles	1.0	1.70956
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047177
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vacuolar membrane	GO Cellular Component Annotations 2015	1.0	null
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.379499
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04398
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9552
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76973159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14804
A204	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.53588
BRD-K56520129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70907
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.018
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31713
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841086
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Urinary bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A50737080_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TMMY-0926-SM-33HBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897537
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.363716
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.47265
BRD-A84913188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34936
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.8851
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-2326-SM-2XCB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26608
foxa1_21151129_mcfdash7_lof_human_gpl10558_gse25315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.129686
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
6847_PSMA7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3171
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.0117
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18621
496100401_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46067
BLTP3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21211
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NCIH2172	CCLE Cell Line Gene Expression Profiles	-1.0	-2.65069
BRD-A55484088_BNTX maleate_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
Mononuclear cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.657
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10576
NANOG-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76296
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88617
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQ7-1826-SM-2S1R5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929599
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161743
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03366
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828884
AKT1_knockout_210_GSE39699	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.88524
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70729
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04514
Necrosis	CTD Gene-Disease Associations	1.0	2.17541
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140096
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09406
JUN kinase binding	GO Molecular Function Annotations 2023	1.0	null
hsa-miR-323b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
3214_FTSJ3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32742
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.42792
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	0.938318
BRD-K03936430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52769
Perturb_2173_KO_Gsdmd_SRP366634	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.32326
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148469
AZ20	DeepCoverMOA Drug Mechanisms of Action	1.0	0.8
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW-48 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
cellular process	GO Biological Process Annotations 2015	1.0	null
bexarotene_homo sapiens_gpl96_gds2777	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH69	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46652
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853375
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163827
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18355
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.285
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_siNOTCH3_FC_1_3_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE159084_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31754
CAS1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.02731
GSE176093_0_v_1_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
VCPIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83002
GSE230354_0_v_1_rheb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRPM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0074832
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.5104
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
LIVF001-027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.74247
sh-sy5y cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.452584
BRD-K82732294_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37892442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28906
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59131688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96497
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17472
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49443
TIMM50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50593
ETV1-20927104-GIST48-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE127916_1_v_2_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
Eccrine acrospiroma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.757
BRD-K02130563_S1030_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4477a	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11B-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.214636
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08277
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9205
SYK_druginhibition_282_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.18087
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
homolog	GeneRIF Biological Term Annotations	1.0	null
Benztropine (mesylate)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134386
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10788
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
8738_TBL3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11592
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of JNK cascade	GO Biological Process Annotations 2025	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949786
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191195
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Darapladib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5848
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128021
UAMC00039	DeepCoverMOA Drug Mechanisms of Action	1.0	0.58
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DT-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DENND4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46483
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87929769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08894
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_NANOG_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44824
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DG-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09251
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825122
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09717
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90493
REST_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE86507,GSE86509_7_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BICR10	DepMap CRISPR Gene Dependency	1.0	2.01601
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919625
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28402
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65524
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877851
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2002
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73864
Uveal melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
Late endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
K562_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269689
SAOS2	DepMap CRISPR Gene Dependency	1.0	4.01835
NEC8	GDSC Cell Line Gene Expression Profiles	-1.0	-1.88644
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11047
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35148
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62665
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08268
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16794
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995966
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19A-06A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Scoliosis, Unspecified	DisGeNET Gene-Disease Associations	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13238
HES3_KD_GSE64449_187_mouse_Min6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844227
BRD-K76829357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03215
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.365
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
klf9_17379758_jejunum_lof_mouse_gpl339_gds2703	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.71414
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.4544
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.94077
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0744
A549_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152643
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.043
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01232
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852437
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Pentoxifylline_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271179
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.064292
hsa-miR-4310	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28017
BRD-K24984327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28825
Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX3	ENCODE Transcription Factor Targets	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39778
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K21386594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32941
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170688
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.01625
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43596
GSE111247_14_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854791
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.775783
H1-0	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32872
GTEX-NPJ7-0011-R9a-SM-2TC5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67836
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147397
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18355
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.967277
Late endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58958
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05431
BRD-K12145385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05306
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KM-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129318
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2396
GTEX-XBEW-1326-SM-4AT63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886987
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.636
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912303
A549_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130152
GTEX-XBED-0826-SM-47JYC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07268
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39757
Feeding Difficulties	DisGeNET Gene-Phenotype Associations	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928795
Marrow cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.657
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226397
MAP3K1_knockout_245_GSE39240	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.75706
Diphenhydramine_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.018859
19294737-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A45498368_WYE-125132_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prader-Willi Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMMY-0526-SM-33HBC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44596
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226249_5_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
waist-hip ratio	GAD Gene-Disease Associations	1.0	null
GSE168797_4_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183638
Castanospermine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051406
GSE87404,GSE87812_2_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
18667080-TableS9	GeneSigDB Published Gene Signatures	1.0	null
DNAJC16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652874
PRT062607	DeepCoverMOA Drug Mechanisms of Action	1.0	1.31
BRD-K09432998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93403
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07516
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0526-SM-32PK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2093
decrease	GeneRIF Biological Term Annotations	1.0	null
BRD-K65432894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1107
MCF7_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0078574
SH4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.80204
BRD-K30895360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01067
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
Perturb_17652_KD_DNMT3A_SRP367237	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.39561
BRD-K66030669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35001
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27364
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5697
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91339
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958351
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36718
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.305
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63425657_NP-010914_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.561362
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55248
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30167
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
urinarybladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.02478
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53108
YY1	ChEA Transcription Factor Targets	1.0	null
GTEX-WFG8-2526-SM-3GILR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01999
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.810221
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230058
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2264
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LY334370	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Lung adenocarcinoma_LUAD_TCGA-38-4625-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39175
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907221
L-779450	DeepCoverMOA Drug Mechanisms of Action	1.0	1.05
P12ICHIKAWA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94093
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66879977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28191
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55462
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33749
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926005
GTEX-XUJ4-2726-SM-4BOQ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869872
Adrenal gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05108
GTEX-S4Q7-1426-SM-3K2B9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06899
BRD-K19266588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17374
BRD-A68123879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29772
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014258
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11638_KD_IL17RE_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.1739
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923452
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243121
rhombomere 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04374
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998723
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
hsa-miR-568	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A58767537_afatinib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCCPAN2	CCLE Cell Line Gene Expression Profiles	1.0	1.55959
NCI-H716 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.057
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WM-266-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.01951
GSE223008_7_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11562_KD_BAX/BAK_SRP348085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-QDT8-0226-SM-32PL4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988422
STK17A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536692
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2272
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A64Z-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01978082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17552
CEBPB	ENCODE Transcription Factor Targets	1.0	null
ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SUCS-1726-SM-32PM8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949616
IRE1-TRAF2-ASK1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43498
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92478
OLIG2	ChEA Transcription Factor Targets	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDGFD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588828
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014145
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03573
BRD-K73395020_ARP 101_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ERBB2IP	MSigDB Cancer Gene Co-expression Modules	1.0	null
primary auditory cortex (core)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997096
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.469
BRD-K49424866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22071
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
layer I of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.835523
BRD-K28596345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47561
Decitabine_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0278784
CRCGN015_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.291
KLF15_KO_GDS4780_419_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923148
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88026
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.83396
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypospadias	CTD Gene-Disease Associations	1.0	1.33909
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Narrow Nasal Bridge	DisGeNET Gene-Phenotype Associations	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.21823
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177536
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19054
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06533
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.469
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4329-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503013
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
GSE135309_0_v_1_tcf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.943226
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r2 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00769
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22701
Binospirone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
SYK_knockdown_189_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.34587
GSE115763_3_v_1_klf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68333644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0068
increased mean corpuscular hemoglobin	IMPC Knockout Mouse Phenotypes	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5491-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4157
Eczema_Integument_GSE6012	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.68409
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14165
BRD-K26767475_NCGC00183255-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32087
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.82544
BRD-K42918627_GSK-2126458_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3144-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04141
GSE210225_0_v_1_inosine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210454
hESC_Derived_CD56+_Ectoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.59601
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.952713
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02006
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168173
cognitive impairment	GWASdb SNP-Phenotype Associations	1.0	0.756753
hsa-miR-181b	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
SNU601	CCLE Cell Line Gene CNV Profiles	1.0	1.4393
Agranular insular area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28267
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
HNF1B_OE_GDS1499_253_human_HEK293 embryonic kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A49848186_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930069
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942549
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28121
Superior olivary complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31399
PHF8	ENCODE Transcription Factor Targets	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.917796
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.204
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184185
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965581
BRD-K08799216_pelitinib_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-997-ZNF430_ZNF430	Rummagene Transcription Factor Associations 2026	1.0	null
Piriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1305
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4137
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-7501-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-WOFM-1626-SM-3MJFX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69707
cellular_component	GO Cellular Component Annotations 2015	1.0	null
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
t58-heart_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.92747
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166257
BRD-A67508925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13314
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.884908
Nuclear inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.483
BRD-K72636697_QL-X-138_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ornidazole_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184492
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03447
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MI-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP2	Achilles Cell Line Gene Essentiality Profiles	1.0	1.38427
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Intercellular bridge	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
Tenascin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.439
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05898
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-SP1_mod_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
MMP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619515
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.842765
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30237
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056533
BRD-K03791970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11046
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931076
GSE116242_0_v_1_olig2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80537_0_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ROS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555579
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CHD1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
FDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561804
Tetracycline (hydrochloride)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232646
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15201
BRD-K09598619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02748
BRD-K80575072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.87384
MF63	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043289
language impairment	GWASdb SNP-Phenotype Associations	1.0	0.756753
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
HEC251	CCLE Cell Line Gene CNV Profiles	1.0	1.33787
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.239197
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151089
TFAP2C	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNMC-1626-SM-4DM52	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45655
MCF7_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026615
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
Aorta thoracica smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.742
Posterior amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01402
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965895
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
PNPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14869
hsa-miR-3609	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.262
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82765
BRD-K20009653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00036
NR3C1	ENCODE Transcription Factor Targets	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5285
neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.614571
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN009_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24616
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00947
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37962
STK869906	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
Endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.51557
AGS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
endosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.598538
ML264_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.020177
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.16305
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00471
BRD-K18533510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68324
CEBPB_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06106
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49443
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23954
A549_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167111
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31835
Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2629	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.23639
GTEX-NPJ7-0011-R2a-SM-2I3GF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01646
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.94059
BRD-K16207265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22964
Toceranib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.71
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76985
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18705
GSE158834_1_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7792-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.100379
Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174914
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26140483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07334
BRD-K79619334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02658
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44672
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Microglial cell_Embryonic prefrontal cortex_Human	CellMarker Gene-Cell Type Associations	1.0	null
endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.626057
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38417
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09681
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_0_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-500a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166366
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPSB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37741
BRD-K21167361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06825
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172739
positive regulation of MAPK cascade	GO Biological Process Annotations 2025	1.0	null
pancreatic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.379875
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-A82843133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51805
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K21547369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17867
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.839903
17177833-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223217
Autosomal recessive spinocerebellar ataxia 24	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
ubiquitin protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29262
Uveal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reticulum	GeneRIF Biological Term Annotations	1.0	null
stressinduced	GeneRIF Biological Term Annotations	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
6844_PSMA4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3252
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0966
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146071
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875352
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070715
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6773
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.916202
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152432_1_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879687
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CCND1	ChEA Transcription Factor Targets	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
BRD-K09434518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3914
Citalopram (hydrobromide)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0143379
Adenoma	CTD Gene-Disease Associations	1.0	1.08655
NO10	DepMap CRISPR Gene Dependency	1.0	3.1293
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06799
Allopurinol_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0182085
GSE126345_11_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-4086-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851
FOXM1	ENCODE Transcription Factor Targets	1.0	null
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
intermediate part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09251
nerve	GTEx Tissue Gene Expression Profiles	1.0	1.61187
K562_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017051
OVCAR8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.08897
Perturb_5204_KO_Rara/Rarb/Rarg_SRP136599	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
MAFK	ENCODE Transcription Factor Targets	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64632
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.53456
BRD-K57282030_JW-7-24-1_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38535
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.824337
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45904718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55405
BRD-K01045229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26962
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148354
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980147
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914467
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33716
Basolateral amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06558
MYC-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hypothalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.871466
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21855
MCF7_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141807
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4490-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5637	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GK_KO_GDS2610_162_mouse_Brown adipose tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
deficit in nonword repetition	GWASdb SNP-Phenotype Associations	1.0	0.756753
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158901
BT549_BREAST	CCLE Cell Line Proteomics	1.0	4.311
WM115	CCLE Cell Line Gene CNV Profiles	-1.0	-2.41375
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32424
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3443
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7349
7142_RBBP6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518889
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.900759
FBXL20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487063
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011191
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A14098586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5674
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K60578515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06665
BRD-K90366266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80365
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13141_KO_Ctr1_SRP165861	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.59149
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Superior olivary complex, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06915
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.606
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE178255_5_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KIF13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.495
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW1417	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01175
GSE180951_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825441
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.252371
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.25321
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
BRD-K58070604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3162
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2072
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10924
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14235_KO_Tet1_SRP237910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.62698
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.71094
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06587
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11C-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_0_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87537204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16593
OVCAR4	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.48538
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87426
MCF7_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205114
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54046
Generalized Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
Mononuclear phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.657
Crizotinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.94
Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22749
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196556
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	2.631
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FER	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548478
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33818
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55C-1926-SM-2TF4K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961869
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30749
BRD-K40685792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0679
BRD-K31393518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54567
BRD-K37831546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04032
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.374
MCF7_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110858
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.58491
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AI-0626-SM-48TZU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16886
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2551
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70668
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CCDC134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14408
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
astroglial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985126
ubiquitin	GeneRIF Biological Term Annotations	1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tazarotene_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0346672
Carvedilol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.52
BRD-K34804325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16638
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central Visual Impairment	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176386
Naproxen_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0315975
Mesothelioma_MESO_TCGA-MQ-A4LI-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LMNB1	Pathway Commons Protein-Protein Interactions	1.0	null
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13881
BRD-K42918627_GSK-2126458_MCF10A_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
17724462-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00072
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38123
MYCN	ChEA Transcription Factor Targets	1.0	null
GSE218060_5_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24565
SW1783	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95563
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.79808
BRD-K85418917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47285
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.387408
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06628
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.82544
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.306632
GTEX-PVOW-1026-SM-2XCF9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00269
BRD-K80240487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77294
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211378
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.32499
Colo-320 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.12805
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055489
2783_EXOC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.638239
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sildenafil_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0288588
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.839903
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8404
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902397
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1857
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02359
Protein storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.397
MCF7_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289577
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69337
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16583
H3K4me1_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2510_KD_EIF4A1_SRP042616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.4571
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28473
r6 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09547
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52694
Asimadoline	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.1186
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061899
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
T47D	CCLE Cell Line Gene Expression Profiles	1.0	1.48805
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855806
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148528
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.830356
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
modification-dependent protein catabolic process	GO Biological Process Annotations 2025	1.0	null
mediator	GeneRIF Biological Term Annotations	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275531
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
Cholestasis	CTD Gene-Disease Associations	1.0	1.02971
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99971319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19848
A549_ZM 447439_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149395
macrophage	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.922935
IRF3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0969
snare complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.385822
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44161
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16283
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74672
Ibutilide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21596
zinc ion binding	GO Molecular Function Annotations 2015	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_7day-MOI-10^3_None_GSE43302	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.65453
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73789395_ZM 336372_PL21_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.827284
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.845789
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.08034
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263049
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0023
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98673
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055692
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10939
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157951
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36821
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0862
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.084131
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A79768653_sirolimus_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08394
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.71094
carmustine-6914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Monocyte_Fetal kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
golgi apparatus part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.157943
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.511702
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06665
BRD-K98805845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41325
KLF15_KO_GDS4780_509_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.489
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17788
protein autoubiquitination	GO Biological Process Annotations 2015	1.0	null
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10418
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940022
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MS (Multiple Sclerosis)_CNS - Spinal Cord (MMHCC)_GSE842	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.824692
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45948
BRD-K65291993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40077
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130983
MCF7_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219075
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125647
BRD-K97236134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29084
GTEX-T6MO-2026-SM-33HB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03743
DALRD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17554
BRD-K32019201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36585
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.20366
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19445
Brain Lower Grade Glioma_LGG_TCGA-CS-6665-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215258
fetus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
cloning	GeneRIF Biological Term Annotations	1.0	null
Colo-678 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.928
BRD-K96979108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14624
BRD-K26241953_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10242447-mmc2.xlsx-TI_DEGs-Table_S1_TIGs_Comparison_between_each_trained_monocyte_sub-population_T3m_LPS_with_monocytes_T0_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2025	1.0	null
Omeprazole (sodium)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0090385
Huperzine A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
modification-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.186
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.816763
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.26945
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58778
(S)-Zopiclone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.61
POLA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615933
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Delayed Bone Age	DisGeNET Gene-Phenotype Associations	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.636363
pparg_21068720_macrophage_c57bl6_lof_mouse_gpl1261_gds4370	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.282885
MCF7_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154993
GREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65123
vacuolar part	GO Cellular Component Annotations 2015	1.0	null
lung	GeneRIF Biological Term Annotations	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80172
endosome membrane	GO Cellular Component Annotations 2025	1.0	null
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181535
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22889
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21731
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16462
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Basolateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61996
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bromopyruvic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24877
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191196
A549_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00920029
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528449
UBE2D4	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140161
UBE2E1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31666
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946965
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09906
BRD-K69505608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29259
BRD-K90548911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.865
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.162546
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871507
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924664
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sweat gland benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.8924
hsa-miR-499-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20734
PMC8253095-MOL2-15-1942-s005.xlsx-gene_lists-Genes_associated_with_H3K27ac-positive_sample_selective_AR_sites_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06465
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.20032
RDES	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64577
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K44576681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29069
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35634
thyroid gland	HPA Tissue Gene Expression Profiles	1.0	1.90418
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33785
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.913407
BRD-K83845379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4792
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967099
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A00327403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64608
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30185
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506938
HCFC1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14245
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.37081
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.44014
BRD-K28264750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36734
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K05649647_-666_PL21_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53476
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51387
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.136276
BRD-A02501536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19538
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.826411
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A23V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74773
mood disorder	GWASdb SNP-Disease Associations	1.0	0.272785
6261_PGM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.64889
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23705
Avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05271
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.39816
A549_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142543
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88155
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.880273
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.189222
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88363
increased mean corpuscular hemoglobin	MGI Mouse Phenotype Associations 2023	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842792
c4i	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MR-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25908
GSE144120_3_v_1_plcg2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166575
efaroxan	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40595
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3363-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59733
golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21178
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36644
Sarcoma_SARC_TCGA-DX-A3U5-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBFbeta_Deficiency_GDS3577_557_mouse_Regulatory T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36873
red nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03732
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SK-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28294
SMARCC1	ENCODE Transcription Factor Targets	1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2977
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8859
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15997423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41351
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.489
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2018
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05285
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE210885_5_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.554
furosemide-1580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K24156250_NCGC00182393-01_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74793
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.67025
TE-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV362	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05341
Medulla oblongata	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20928
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51962
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156425
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864316
Aorta smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16777
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193658
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152889
Gustatory areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35915
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5629-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16625
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195454
ligase	GeneRIF Biological Term Annotations	1.0	null
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34355
KYM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.896071
A549	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.03731
SW1463	DepMap CRISPR Gene Dependency	1.0	6.14633
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210524
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.1491
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.39507
WHSC1	ENCODE Transcription Factor Targets	1.0	null
membrane region	GO Cellular Component Annotations 2015	1.0	null
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16758
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864745
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.07142
CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
learning disability	GWASdb SNP-Disease Associations	1.0	0.397502
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00014
SB 218795	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
BRD-K84239940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12132
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63002
GTEX-WHPG-0826-SM-3NMBF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859896
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37204
HUG1N	CCLE Cell Line Gene CNV Profiles	1.0	1.47504
VU 0364739	DeepCoverMOA Drug Mechanisms of Action	1.0	1.8
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02134
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.872052
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28394
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966426
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962892
GAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504383
BRD-K50168500_canertinib_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75429775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10839
layer 3 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31526
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.43312
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223227
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545076
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nephritis, Interstitial	CTD Gene-Disease Associations	1.0	1.02003
KAT2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03514
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1912
Lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133363
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.567087
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067174
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057469
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06772291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14034
OVISE	CCLE Cell Line Gene CNV Profiles	1.0	1.95225
cell property	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087567
hsa-miR-4668-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
IRS3P_KO_GDS1219_305_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52358
BRD-K73092207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30122
SNU503	CCLE Cell Line Gene Expression Profiles	1.0	1.64387
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08092
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vagina	HPA Tissue Protein Expression Profiles	1.0	0.908244
MXI1	ENCODE Transcription Factor Targets	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hyperplasia	CTD Gene-Disease Associations	1.0	1.81429
CXCL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00698332
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13857
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SK-MEL-2	GDSC Cell Line Gene Expression Profiles	1.0	1.4723
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15635
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.82544
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09835
ar_21330406_lncap_lof_human_gpl570_gds4113	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.449011
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291415
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCFCP2L1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194668
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.21145
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84316
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.99537
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4209
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2123
JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.44275
GTEX-P4PQ-1726-SM-3NB15	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840684
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9827
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.16533
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921009
NCF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00442957
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.271255
Sarcoma_SARC_TCGA-QQ-A8VG-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94834
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4978
Weight Gain	CTD Gene-Disease Associations	1.0	1.27286
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.72447
PF429242	DeepCoverMOA Drug Mechanisms of Action	1.0	0.67
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.657
GSE210655_3_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
Prp19 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
GSK3A_knockdown_201_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.68573
ubiquitin-like protein transferase activity	GO Molecular Function Annotations 2015	1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.374
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06093
hsa-miR-4524	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.831838
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881975
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.831097
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
MiaPaCa-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.165
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87849910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68681
MCF7_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120323
zona incerta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.91365
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7485-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.324823
Minodronic acid_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242603
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7548
Perturb_2509_KD_EIF4A1_SRP042616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.612
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.36019
BRD-K71210410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95985
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155161
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44848
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0051
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12924
A549_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152928
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.546991
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH23	Achilles Cell Line Gene Essentiality Profiles	1.0	1.00295
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T8EM-1526-SM-3DB7I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06366
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6126
ZNF131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05052
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.924043
Learning Disorders	CTD Gene-Disease Associations	1.0	1.72343
GSE155031_5_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.12426
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PIK3R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09703
BRD-K85051145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04692
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858289
nb4	HPA Cell Line Gene Expression Profiles	-1.0	-1.53212
CRCGN017_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42715
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62722
mantle zone of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07798
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872044
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OVISE	CCLE Cell Line Gene Expression Profiles	1.0	2.16825
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.23185
USP6NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28928
GTEX-QEG5-1126-SM-33HC2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907813
protein storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.561358
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OCT4-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33551950_R2146_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Congenital Microcephaly	DisGeNET Gene-Disease Associations	1.0	null
MZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.995557
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47339
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2295
muscle fibre	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.578416
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.24336
Folic acid_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0215214
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633636
MAP4K4	MSigDB Cancer Gene Co-expression Modules	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.835898
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00014
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06772
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.851796
BRD-K90480740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74928
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17250_KO_Il17a_SRP069071	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.32102
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Multiple benign melanocytic nevi_Epidermis_GSE3189	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.55965
CTCF	ENCODE Transcription Factor Targets	1.0	null
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060744
erg_19359602_huvec_lof_human_gpl570_gds3557	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.644202
BRD-K37431309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92955
NRSF	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6849_PSMB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.49236
BRD-K69423881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00521
substantia nigra reticulata, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09251
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0305025
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-1626-SM-3DB74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926163
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14122
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997236
GTEX-QDVJ-0726-SM-48U1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855736
BRD-K46014293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73215
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70E-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62185
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5686
USP17L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47172
BRD-A79248021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06961
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13501
Sensorineural Hearing Loss (Disorder)	DisGeNET Gene-Disease Associations	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37004
Lung adenocarcinoma_LUAD_TCGA-49-4512-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190294
DMRTC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83186
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K48845054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40778
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13442
BRD-K25200031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21605
IZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.897339
TMP269	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
PMC11093744-41592_2024_2172_MOESM3_ESM.xlsx-ELP-genes_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19009
DEF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601565
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07488
bone marrow	HPA Tissue Protein Expression Profiles	1.0	0.908244
Myocardial infarction	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1
BRD-K44366801_NCGC00182371-01_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841086
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.68281
BRD-K05970499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24852
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9967
SYK_druginhibition_152_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.98642
BRD-K11662217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37027
Acute Myeloid Leukemia_LAML_TCGA-AB-2888-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.909347
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021671
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215991
Erdafitinib _A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0117279
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.834246
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.78955
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.38796
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58888361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17065
BICR22	CCLE Cell Line Gene CNV Profiles	1.0	3.11872
STK155799	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
Vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2309
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.16811
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59384
GSE190384,GSE190386_2_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
FBRS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05593
BRD-A79768653_sirolimus_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-P4QT-1726-SM-2S1NQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904565
Berzosertib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.32
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Perturb_1811_KO_Nr1h2/Nr1h3_SRP158140	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.25003
hESC_Derived_CD184+_Endoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.35925
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-USF2_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.66653
Brain Lower Grade Glioma_LGG_TCGA-DB-5276-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-570	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235556
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18122
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2657
APEX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24105
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35613
BRD-K19418944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24725
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68056389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00415
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6455
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.1114
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55328
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02708799_GSK-1059615_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.94587
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7963
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-129-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Piriform-amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64626
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874001
SNU81	DepMap CRISPR Gene Dependency	1.0	5.33094
late endosome membrane	GO Cellular Component Annotations 2023	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23389
PF-3758309	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.75
15520171-Table1	GeneSigDB Published Gene Signatures	1.0	null
MYC-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
1771_COPB1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517255
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7427_RPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578873
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
miapaca-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.727741
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7479-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lapatinib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.16
Perturb_10391_KD_BRDT_SRP273737	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150006
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967128
GSE178255_5_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ1-1326-SM-4DXU7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20528
BRD-K31441930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0362
BRD-K60429174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37013
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.70906
Sepsis_Splenocyte_GSE4479	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.66274
metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC4728380-ncomms10153-s8.xlsx-High_affinity_MYC_Targets-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.3386
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7918-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01651394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32607
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32789
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0895
MCF7_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245441
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.234
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056327
A2780_OVARY	CCLE Cell Line Proteomics	1.0	2.19322
SETDB1	ENCODE Transcription Factor Targets	1.0	null
A549_Danusertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197015
KLHDC7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63323
BRD-K52956006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1166
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Prostate adenocarcinoma_PRAD_TCGA-EJ-8468-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35146
BRD-K24333636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45465
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.924491
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rosiglitazone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
PDS5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00450824
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1782
pancreatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.365193
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54498
GTEX-R55E-1326-SM-48FCR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835758
late endosome membrane	GO Cellular Component Annotations 2015	1.0	null
C11orf24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36806
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Dapagliflozin_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0346248
MAZ	ENCODE Transcription Factor Targets	1.0	null
COLO-320-HSR	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61981
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PBX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06628
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10257_KD_TP53_SRP346937	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.4072
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ABL127	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900819
Perturb_5371_KO_Dcaf11_SRP201454	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.45711
BRD-K84895041_BMY 45778_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-0.899355
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.89831
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218903
HEC251	CCLE Cell Line Gene Expression Profiles	1.0	1.49974
basomedial amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12116
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85196
GSE144919,GSE145177_1_v_0_dazl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.94996
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.38156
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRF8-27001747-CHIP-SEQ-BMDM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574367
A549_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179087
PMC4641642-pone.0142229.s010.xls-AP2-GeneSymbol_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19928
BRD-K24494475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02372
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64917
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8242
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37568
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20209
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17457
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7185_RBM8A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13974
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
point	GeneRIF Biological Term Annotations	1.0	null
BRD-K59120074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3155
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.14327
Fusidic acid_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00963138
FOSL2	ENCODE Transcription Factor Targets	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE88819_5_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60484506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50841
GTEX-S3XE-1926-SM-3K2B3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915784
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87268607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49429
Basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901597
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566784
vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.123288
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136457
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.932604
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A68061604_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.76037
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03585
GTEX-U3ZM-0526-SM-4DXTB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944816
NVP-BHG712	DeepCoverMOA Drug Mechanisms of Action	1.0	1.23
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541497
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74473
Myocardial infarction	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5377
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19759
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32584
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3689d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K03352270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01095
SNAPIN	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.49065
GSE210225_0_v_1_uba6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K15779027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08453
A 438079	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052765
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nuclear envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.323825
lysosome	GO Cellular Component Annotations 2025	1.0	null
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Dabrafenib_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0202934
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K29331543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91479
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41306114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75661
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	2.11039
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal sleep behavior	IMPC Knockout Mouse Phenotypes	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.970276
Failure To Thrive	DisGeNET Gene-Disease Associations	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12568
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24103
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5252
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
ESR2_01_229	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.68
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977063
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_TMP195_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184573
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.219398
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.927
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13524
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955574
CP21R7_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00842862
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68057
MAX	ENCODE Transcription Factor Targets	1.0	null
VA-ES-BJ	GDSC Cell Line Gene Expression Profiles	1.0	2.06618
hsa-miR-4793-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Prostate adenocarcinoma_PRAD_TCGA-EJ-7785-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.09775
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97134
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5551
A549_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186631
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12208
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37835
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16367
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8216-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VJYA-0326-SM-3GAEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03189
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.870396
Gallic acid_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.017882
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI H23	BioGPS Cell Line Gene Expression Profiles	1.0	0.887117
rnf13	GeneRIF Biological Term Annotations	1.0	null
GTEX-SIU8-0326-SM-2XCDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00694
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24094
PGRMC1	Pathway Commons Protein-Protein Interactions	1.0	null
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K98437821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76485
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.83977
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04706
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13642
IPC298	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92795
Esmolol (hydrochloride)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196811
Goserelin (acetate)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0134705
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12248
MCF7_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017587
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.19431
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176216
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8875
BRD-K75853175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25846
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.969628
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
hsa-miR-106b	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.838771
GSE158834_1_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65765
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93743
Thiothixene	DeepCoverMOA Drug Mechanisms of Action	1.0	1.22
posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.83301
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35873
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.872551
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146441
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3HR-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gigantocellular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0044
lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06992
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medial part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37339
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.57784
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.66712
LNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30209
Pain	CTD Gene-Disease Associations	1.0	1.0561
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Mebendazole_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00697867
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106712
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170736
layer 2 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43945
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73574487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79244
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.85003
AP2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48956
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2245
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	1.53394
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K30821056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35906
limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221434
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914261
FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27588
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A19500257_geldanamycin_SKBR3_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCM2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25622
SP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMARCC2	ENCODE Transcription Factor Targets	1.0	null
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06717
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22697
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884351
MCF7_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00887793
A549_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0249932
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31292
vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K42455150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15442
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00099
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
Colo-205 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
BRD-K13804959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27792
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08435
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.861928
cisplatin_homo sapiens_gpl570_gse23553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202608
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154564
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42867
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23588
Perturb_16437_KD_NUDT21_SRP221381	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
lymphnode_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.28012
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839672
A549_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168309
hek-293t cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.59405
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
NANOG	ChEA Transcription Factor Targets	1.0	null
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987103
BRD-K30563122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76898
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00014
acute	GeneRIF Biological Term Annotations	1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9601
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018264
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
pancreatic	GeneRIF Biological Term Annotations	1.0	null
Perturb_2511_KD_EIF4A1_SRP042616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.64782
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.20917
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118767
orbital frontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48978
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7812
BRD-K39087188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19931
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02787
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82796
Perturb_13946_KD_SAPCD2_SRP342327	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K69932463_AZD8055_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Regorafenib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0283651
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146595
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PIGF_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.95992
A549_JQ1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217321
vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Hydroxyurea_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0259743
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12734
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94301203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15027
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2216
PMC9362915-pone.0272017.s003.xlsx-Day5_-0_7_Top-BBX_BBX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ibrutinib2	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03487
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.03786
A549_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140089
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein autoubiquitination	GO Biological Process Annotations 2025	1.0	null
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
layer 5 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07684
PFKFB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006744
A549_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133228
hydrocortisone_homo sapiens_gpl570_normal scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23638
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61661017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25734
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.15156
GTEX-PVOW-1626-SM-48TC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825048
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	2.95131
Sarcoma_SARC_TCGA-DX-A1L2-01A-22R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4679	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K21009787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12792
mRNA_KLF4_18264089	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00471
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93292
4554_LEPROTL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621117
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39228
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82841
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.950193
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1394
NFYA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.918253
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
hsa-miR-181d	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.841213
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164226
BRD-K17583574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07381
Perturb_5033_KD_Smarca4_SRP221174	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.85771
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140319
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12968
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_940_KO_GRK6_SRP301945	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179829
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.849066
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.970381
endosomal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K12929741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4952
STAT5A	ENCODE Transcription Factor Targets	1.0	null
PIPOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631321
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39492
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S341-1926-SM-3K2BA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68972
GTEX-P4PQ-1626-SM-2HMKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22152
NRBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01078
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31754
[Pyr1]-Apelin-13	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
protein binding	GO Molecular Function Annotations 2015	1.0	null
MCF7_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134107
MCF7_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135865
endomembrane system	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.33511
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88378636_withaferin-a_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.40092
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.868619
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
L-Eflornithine (monohydrochloride)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0277947
A549_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199705
ISTMES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77779
EGR-1_KO_GDS3607_525_mouse_Retina - 30 Days (POST-NATAL)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3644
Sweat gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
BRD-K22229548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40869
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881015
nucleus subceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00919
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54573
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.33464
GTEX-R55G-2126-SM-2TC67	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988413
Zinc finger, RING-type	InterPro Predicted Protein Domain Annotations	1.0	null
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562453
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.06037
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136878
BRD-K44344720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17824
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.825033
H3K4me1_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505143
ZNF384_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6010-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	2.08633
Perturb_14093_KD_HDAC1_SRP199194	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.94651
Glioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
igr39	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
SOX2	ChEA Transcription Factor Targets	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PL4	DepMap CRISPR Gene Dependency	1.0	6.85752
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YAP1-20516196-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
KMRC3	DepMap CRISPR Gene Dependency	1.0	3.20361
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21182
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03299
rpmi8226	HPA Cell Line Gene Expression Profiles	1.0	1.48992
BRD-K44366801_NCGC00182371-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886338
rostral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36229
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14769
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
RAB3A_Mutation - D77G point mutation_GDS2483_697_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-VUSG-2726-SM-4KKZJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44708
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.79883
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4055
RDES	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45084
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
IRF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017189
MCF7_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215525
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0306373
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54917
GSE190384,GSE190386_1_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201809
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05144
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26471
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45724
BRD-K68984041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29578
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20376
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983108
cation-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.548
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48088
POU2F2	ENCODE Transcription Factor Targets	1.0	null
mRNA regulation complex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48549
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62882
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Cilostazol_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.027975
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4762-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE240468_3_v_6_nfyc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A76899420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28713
A549_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226783
OVCAR8	Achilles Cell Line Gene Essentiality Profiles	1.0	2.14422
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TT	CCLE Cell Line Gene CNV Profiles	1.0	1.61066
hsa-miR-496	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Acute Myeloid Leukemia_LAML_TCGA-AB-2916-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11662_KD_PPP1CB_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.00808
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92317137_-666_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.873057
MCF7_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210586
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199961
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.863271
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71823
BRD-K53552465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17148
BRD-K19925255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73733
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU5F1	ChEA Transcription Factor Targets	1.0	null
UBE2D2	Pathway Commons Protein-Protein Interactions	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.864478
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09117
Irinotecan (hydrochloride)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02739
Lung squamous cell carcinoma_LUSC_TCGA-66-2742-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52807
6853_PSMB5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33832
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23906
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64008
CRCGN012_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20318
BRD-A51540388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05629
late endosome	GO Cellular Component Annotations 2025	1.0	null
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80255
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MC-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34942615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17082
BRD-K85402309_dovitinib_SKBR3_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162349
pancreas adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.541992
protein modification by small protein conjugation	GO Biological Process Annotations 2015	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4176
superior periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29598
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.861294
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12863
BRD-K50413145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85283
MYC-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K27621887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74958
NCIH2170	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39238
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182293
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.910142
layer 1 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47532
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.973026
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26533
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A35931254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05337
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28267
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22495
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.044553
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133399
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24958
OTS514_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0115959
BRD-K83752863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16943
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19222
proteaseactivated	GeneRIF Biological Term Annotations	1.0	null
primary auditory cortex (core)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06694
NFE2	ENCODE Transcription Factor Targets	1.0	null
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Coronary artery disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMARCC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209725
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08133
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155874
MCF7_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123377
Perturb_5825_KO_Pax5_SRP185455	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
MCF7_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157192
BRD-K23085156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25209
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10006
BRD-U28903152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08672
AT 406	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
superficial stratum of InsCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12503
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44746
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0895
GTEX-WYJK-0326-SM-3NMA8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876153
Acute Myeloid Leukemia_LAML_TCGA-AB-2981-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
astroblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181225
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05332
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-0426-SM-3GIL4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875142
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r5 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43597
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11258
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04932
BRD-K99116119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37493
primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.90032
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K56417082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19556
Naproxen_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214676
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052806
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825865
BRD-K79090631_CGP-60474_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0066
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152757
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00319
superficial stratum of r2BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00769
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168586
SIAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17463
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bombesin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.957201
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0116
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84624
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
Lung adenocarcinoma_LUAD_TCGA-73-4676-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08357
BRD-K95574976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5745
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122496
TEAD4	ENCODE Transcription Factor Targets	1.0	null
LCL161	DeepCoverMOA Drug Mechanisms of Action	1.0	0.57
Ruboxistaurin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.76
FOXA1	JASPAR Predicted Transcription Factor Targets	1.0	null
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.882011
CBX3	ENCODE Transcription Factor Targets	1.0	null
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01471
r7 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14044
BRD-K66179451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49969
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ht55	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39353
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121632
KOPN8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87929
14768006-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
Amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152133
GTEX-WY7C-2626-SM-3NB2P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13482
BRD-K95900761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77558
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832788
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940449
hsa-miR-4736	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.65575
GTEX-XOTO-0326-SM-4B66K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981959
RUNX2-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RPL32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20653
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44172
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERG	ChEA Transcription Factor Targets	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19285
BRD-K68663367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39879
AC-7954	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15241
Developmental and epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38995
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.834332
BRD-K16746805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04648
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057942
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
19096012-TableS3	GeneSigDB Published Gene Signatures	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.07949
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02185
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.704465
BRD-K71839680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49455
BRD-A04231641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16149
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27448
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Table_S5A_Upregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16888026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06451
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:N01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13933
GTEX-S95S-1526-SM-2XCDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01143
LIVF001-005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10529
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00373
BRD-A60877539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20625
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RB1_KD_GSE50532_623_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.76619
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10095
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.923044
Lung adenocarcinoma_LUAD_TCGA-49-6743-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6867_PSMD13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03548
cefprozil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10777
PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
TE-5	GDSC Cell Line Gene Expression Profiles	1.0	2.46759
Perturb_1138_KO_Ahr_ERP113014	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.96443
NCIH1105	CCLE Cell Line Gene CNV Profiles	1.0	1.39898
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.56594
COLO800	CCLE Cell Line Gene Expression Profiles	1.0	1.49453
PMC2866657-pone.0010547.s003.xls-ESE3_corr-Genes_correlated_anticorrelated_to_ESE3_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
ATP5F1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40936
nuclear membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.520206
Infertility, Male	CTD Gene-Disease Associations	1.0	1.54669
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.93587
Sunitinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00571439
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29127
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	0.858054
A549_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181379
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172692
mice	GeneRIF Biological Term Annotations	1.0	null
AVPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696214
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83736
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04393
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.169091
ALK_KD_GDS2724_105_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K81418486_vorinostat_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r5 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43597
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173858
TAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048515
BRD-K26208451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48417
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09906
lysosome	GO Cellular Component Annotations 2023	1.0	null
GSE167886_3_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLR26	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.27531
GSE210580_0_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18775
MCF7_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184052
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22827
CAL-27	GDSC Cell Line Gene Expression Profiles	1.0	1.62459
CRCGN011_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00525
CBFB_01_43	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59801
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911258
MCF7_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210321
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20084
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36726853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68486
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46151
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578833
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	3.67029
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014576
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0612
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04371
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.80251
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156286
RAB10	MSigDB Cancer Gene Co-expression Modules	1.0	null
SAMD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00415509
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.866304
endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.460401
PMC6078963-41467_2018_5311_MOESM9_ESM.xlsx-PPARD_CHIP_vs_RNA_CD34-PPARD_macrophages_Vs_RNA_CD34_OE_DEGs_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
Early infantile epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.988454
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100955
BRD-K54903703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07051
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.353
vitamin c_mus musculus_gpl6246_gse19378	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15969
GNG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00724658
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22105
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065714
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26885
BRD-K10638173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44099
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78308
Hip Dysplasia	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37861
report	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.946732
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829896
sodium:potassium-exchanging ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
KCTD12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00714334
Torasemide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048031
REST	ENCODE Transcription Factor Targets	1.0	null
Agranular insular area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15892
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00947
BRD-K04531886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05184
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
17699775-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pollen coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.612
SPI1	ChEA Transcription Factor Targets	1.0	null
BRD-K75779523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40691
glia	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62816
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Abemaciclib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294432
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1252
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94748
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.42618
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01839
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52339742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08787
lysosomal membrane	GO Cellular Component Annotations 2023	1.0	null
BRD-K36465335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04155
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142577
A549_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191593
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.62467
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
LU-65	COSMIC Cell Line Gene CNV Profiles	1.0	2.49065
PMC9314667-Table_1.xlsx-Regulons-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21894
BRD-K28923989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3054
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.23137
MEL270	DepMap CRISPR Gene Dependency	1.0	2.42312
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_up-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
K562_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168817
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K85112460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15019
6841_PSMA1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.70317
specific developmental disorder	GWASdb SNP-Disease Associations	1.0	0.361471
NCIH650	DepMap CRISPR Gene Dependency	1.0	4.66291
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.21823
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17505
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018567
decamethonium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61917
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30952
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14146
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16736
GTEX-X3Y1-2426-SM-3P5Z7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00407
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.19862
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20457
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993972
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gustatory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24149
SNF5_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66859
Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.827078
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.208
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.172201
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_6_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55393423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74343
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74797618_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2665
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31941
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.72343
BRD-K58300049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31347
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.919962
Sunitinib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0119073
BRD-K21215763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21104
ETS1_01_244	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59055
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0816
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.47671
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.82871
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tofacitinib_NCI-H596	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0325275
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24007
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1044
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8528
Lung squamous cell carcinoma_LUSC_TCGA-18-3411-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4077-01B-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10546
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70175
JAK1_druginhibition_166_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.835636
GSE111102,GSE111105_8_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LY2090314_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0215096
nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.175146
BRD-K81473043_-666_SW948_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cellulose synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.654
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FASTKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81264
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00373
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135668
17555561-Table2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K67566344_KU-0063794_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SETDB1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K47238978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14368
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.28326
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.006347
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23419
mania	GWASdb SNP-Phenotype Associations	1.0	0.436883
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0301787
mantle zone of LPrP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27516
TAF1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3606	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135451
NFIC	ENCODE Transcription Factor Targets	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HO-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39179
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
MCF7_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144702
Eccrine sweat gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.818
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42653521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39495
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228874
BRD-K95129711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1254
GSE178255_2_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ligase activity	GO Molecular Function Annotations 2015	1.0	null
hsa-miR-491-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
ELK1	ENCODE Transcription Factor Targets	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46517
hsa-miR-4652-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-1426-SM-2S1QU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11691
BRD-K10505056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10726
carcinogenesis	GeneRIF Biological Term Annotations	1.0	null
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.44875
18451145-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152621
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149031
protein kinase binding	GO Molecular Function Annotations 2025	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936326
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.9279
GSE221742,GSE221743_1_v_2_sipa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11165361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53254
Saracatinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.73
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
RNPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80951
ETS1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278169
10074-G5	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838106
A549_Tozasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.016553
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965581
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7838-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860528
REST_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
M140325	DepMap CRISPR Gene Dependency	1.0	19.3355
A549_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200718
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190119
MFE-280	COSMIC Cell Line Gene CNV Profiles	1.0	2.49065
hsa-miR-4693-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
mepacrine-1563	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04886976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75381
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7839
A549_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016966
MOLM16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.25818
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16486
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
UACC257	BioGPS Cell Line Gene Expression Profiles	1.0	1.12874
hsa-miR-3929	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.839903
A549_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132831
BRD-K99546030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09049
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF580	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46756
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCS 1102	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K36376229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.27089
BRD-K58674774_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_NANOG_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
lysosomal membrane	GO Cellular Component Annotations 2015	1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44397
MCF7_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189913
Weight Loss	CTD Gene-Disease Associations	1.0	1.48736
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11021
GSE168676_2_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.08047
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227381
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-up_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HNT34	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.02077
15817677-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K04468899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43184
Lissencephaly 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU685	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32484
GTEX-TML8-1626-SM-32QOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44782
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178255_3_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273003
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88277
injury	GeneRIF Biological Term Annotations	1.0	null
BRD-K91022335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68235
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5515-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3065-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
Mirabegron	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01042
HCC95	CCLE Cell Line Gene CNV Profiles	1.0	1.99968
GATA1	ChEA Transcription Factor Targets	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.532
GSE129244_0_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZM-226600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35795
Fish- and plant-related diet	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
organelle part	GO Cellular Component Annotations 2015	1.0	null
ITK_knockout_241_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.32753
BRD-K19066553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31389
Prostate adenocarcinoma_PRAD_TCGA-HC-8259-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein ubiquitination	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TYKNU_OVARY	CCLE Cell Line Proteomics	1.0	2.80447
layer 3 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3368
hsa-miR-4307	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83661
MCF7_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131499
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.35934
GTEX-UJHI-0126-SM-4IHLP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90061
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.645
r5 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10721
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86687
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22283
BRD-K75985122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08036
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52292
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.84356
MCF7_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117347
BRD-K42976515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31364
Omeprazole (sodium)_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00726391
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3332
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-374c	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
WM2664	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14842
KYSE270	CCLE Cell Line Gene Expression Profiles	1.0	1.4082
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93331
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.02216
depression	GWASdb SNP-Phenotype Associations	1.0	0.348264
Perturb_14988_KO_Phf8_SRP093797	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.11424
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CWC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09679
NFYB	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150191
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27704
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	1.80799
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198817
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18355
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16942
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36518
MCF7_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144142
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epileptic Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K88378636_withaferin-a_MCF10A_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S32W-2526-SM-2XCB8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04178
BRD-K21254338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12243
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130335
TRPM7_overexpression_305_GSE23102	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.2865
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1369
BRD-K10385824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84453
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SJRH30	CCLE Cell Line Gene Expression Profiles	-1.0	-1.91262
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19574
JURKAT	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.853418
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75995
MCF7_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222914
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100464_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.013
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139524
496100626_FWM_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15201
skeletal muscle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14483
LMSU_STOMACH	CCLE Cell Line Proteomics	1.0	3.77973
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.509576
BRD-A31962514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11081
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
language disorder	GWASdb SNP-Disease Associations	1.0	0.863433
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
18535662-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
STAT1-17558387-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
r6 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32123
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35404
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20287
organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.10562
hsa-miR-107	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970507
t64-ovaries_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.38806
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18343
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95675
BRD-A66861218_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32954
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154904
BRD-K58779593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15022
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20F-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22827
MCF7_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100378
AM-38	GDSC Cell Line Gene Expression Profiles	-1.0	-2.05906
POU5F1-26923725-CHIP-SEQ-MESODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07476
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW-1417 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
Rifaximin_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0134974
MDAMB361	DepMap CRISPR Gene Dependency	1.0	2.64962
BRD-K23404017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03993
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PG-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.19512
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Midface Retrusion	DisGeNET Gene-Phenotype Associations	1.0	null
pancreatic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.388535
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30628727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07593
Gustatory areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05884
RRP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11218
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8330-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55160477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14753
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3678
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
BRD-K56801250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21336
PMC3470785-NIHMS377161-supplement-3.pdf-592-ZNF597_ZNF597	Rummagene Transcription Factor Associations 2026	1.0	null
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.993099
SP2	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00471
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
19797726-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
MCF7_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146357
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
BRD-K60918542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59658
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84097
DOV13	DepMap CRISPR Gene Dependency	1.0	4.28258
2750_ETF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528348
Sarcoma_SARC_TCGA-DX-A3LY-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE85302_0_v_1_kat6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.601012
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87958
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21974
BRD-K77425312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38551
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03312699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67621
Perturb_13108_KO_Mbnl1/Mbnl2_SRP045573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.24897
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_5414_KD_SCRIB_SRP300624	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.31807
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
spinal cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
9857_WEE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16248
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.99961
CDK4_knockdown_143_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.21584
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02445
BRD-K12624449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39517
6843_PSMA3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42853
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CADOES1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.54311
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12813
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124933
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161994
BRD-K94012289_OSI-027_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	2.13541
layer 3 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03815
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.103413
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69666
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015782
MYBL1_KO_GDS4485_350_mouse_Testis from 17 day old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CHD2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964866
VPC23019	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
BRD-K60729758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6067
TCF12	ENCODE Transcription Factor Targets	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50081
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217554
TCF12_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.365
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of LPrP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45398
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rapid	GeneRIF Biological Term Annotations	1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.046
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275547
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211962
NCI-H1770	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44759
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41109
HUC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
GTEX-QCQG-2026-SM-2S1PH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04177
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01033
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00115
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE188382_2_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A25184723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09218
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122672
VE-821	DeepCoverMOA Drug Mechanisms of Action	1.0	0.89
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7128-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TXK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566826
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71121
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.945109
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Choline	CTD Gene-Chemical Interactions	1.0	null
18547747-Table1	GeneSigDB Published Gene Signatures	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.448
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16658
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77811
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5474-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41992
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.118251
OCIAML3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.42259
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TI-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25193509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44965
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05132
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98651
BRD-K05975035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59605
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32253
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97332312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34972
pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.091802
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42727
BRD-A77164655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22399
Lung Injury_Lung Tissue_GSE1541	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.55856
CRCGN016_MCF10A.TP53.M_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12387
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-2226-SM-3GILQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43781
mantle zone of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67947
communication disorder	GWASdb SNP-Disease Associations	1.0	0.863433
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13216
BRD-K50191826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82522
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.956222
ventropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1668
SCH	GDSC Cell Line Gene Expression Profiles	1.0	2.69631
TFAP2A	ENCODE Transcription Factor Targets	1.0	null
BRD-K10325583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02211
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.910123
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1725
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40221
TCS PIM-1 1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SMARCC2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196053
AM095	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
regulation of stress-activated protein kinase signaling cascade	GO Biological Process Annotations 2023	1.0	null
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
oral mucosa	HPA Tissue Protein Expression Profiles	1.0	0.908244
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
OAW28	CCLE Cell Line Gene CNV Profiles	1.0	1.52907
BRD-K48549243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20546
GSE138863_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.994151
GSE127970_2_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184508
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.82992
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161492
CHD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17058
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.911171
A549_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207278
A549_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0299443
GTEX-NFK9-0426-SM-2YUNK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943024
BRD-K81418486_vorinostat_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.912457
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864697
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52471
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
endosomal	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25273
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.842823
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195897
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
UCHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15231
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC23A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62588
SPI1	ENCODE Transcription Factor Targets	1.0	null
NCI-H508	COSMIC Cell Line Gene Mutation Profiles	1.0	null
speech disorder	GWASdb SNP-Disease Associations	1.0	0.863433
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH6	CCLE Cell Line Gene Expression Profiles	-1.0	-2.38369
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79698
6855_PSMB6_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.066
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ibutamoren	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
SRF-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137722
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30157
GTEX-VUSG-1226-SM-4KKZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05429
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171874
Lung adenocarcinoma_LUAD_TCGA-91-6829-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148435
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3599
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70468140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06695
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13688
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159453
BRD-K49328571_dasatinib_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53979
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myelencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.097
Gustatory areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26443
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80945184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08034
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06201
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72294
chicken	GeneRIF Biological Term Annotations	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6094
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	2.13675
18757322-TableS1	GeneSigDB Published Gene Signatures	1.0	null
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166697
A549_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186241
HEPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22552
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein ubiquitination	GO Biological Process Annotations 2023	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_2day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.65509
cation binding	GO Molecular Function Annotations 2015	1.0	null
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177474
u266	HPA Cell Line Gene Expression Profiles	1.0	1.12692
SW1783	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49072
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115719
NANOG-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15518
BRD-K29011844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7271
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SF539	DepMap CRISPR Gene Dependency	1.0	2.31986
Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.56068
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.258064
mt12	GeneRIF Biological Term Annotations	1.0	null
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.90253
GSE227698_5_v_3_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHWD-2326-SM-3LK6Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894268
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File010.xlsx-ChIP-seq_defined_target_genes-PBX1_and_Notch3_common_target_gene_list_621_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66668
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3089461-supp_gkq1313_nar-02376-m-2010-File010.xls-Table_S6-TF_targets_of_E2F4_from_our_ChIP-seq_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
Daidzin_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0384777
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22239
BRD-K23405293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73059
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
apoptosis	GeneRIF Biological Term Annotations	1.0	null
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.12872
Aliskiren_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.026221
hsa-miR-548g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29865
BRD-K61168922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33588
BRD-K30597925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76198
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964706
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48978
LU65	CCLE Cell Line Gene Expression Profiles	1.0	1.84623
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4121
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K77808555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37526
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0583
GTEX-WL46-0426-SM-3TW8J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854814
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50273
BRD-K29549246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02554
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.69884
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-2K-A9WE-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199454
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.966988
BRD-U51951544_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58182
MCF7_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173391
BRD-A63759745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15217
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115521
SW900	GDSC Cell Line Gene Expression Profiles	-1.0	-2.27121
H4K8ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052116
STAT3	ChEA Transcription Factor Targets	1.0	null
late endosome membrane	GO Cellular Component Annotations 2025	1.0	null
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24515
Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2837-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rnf167	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1258
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K84478344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18454
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17345
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.67456
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26429
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.831616
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00801
Sebocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45745
MCF7_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129774
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7407-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07199
TEAD4	ChEA Transcription Factor Targets	1.0	null
organelle inner membrane	GO Cellular Component Annotations 2015	1.0	null
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11346
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883297
hsa-miR-106a	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90856
BICR22	CCLE Cell Line Gene Expression Profiles	1.0	2.98795
BRD-K69932463_AZD-8055_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
facilitating	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45852
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
hsa-miR-144	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Narrow Forehead	DisGeNET Gene-Phenotype Associations	1.0	null
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557882
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862936
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB3A_KO_GDS2483_701_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217193
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0169
BRD-K61845512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04285
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8498
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4555
BRD-K23208879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35229
BRD-K44003352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48603
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.946243
GSE129244_0_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
retropontine reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29264
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71138333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66706
GTEX-WH7G-0726-SM-3NMBM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883816
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10721
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatitis	CTD Gene-Disease Associations	1.0	1.14507
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.03719
ERN1	Pathway Commons Protein-Protein Interactions	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21731
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62383
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.46225
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.966988
NCIH2029	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7444
YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27462
RCC-JF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931881
Monocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.657
macroglia	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Clobetasol propionate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141466
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010114
TMEM231	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05341
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Linagliptin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.07233
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prospore contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.537
GSE196117_6_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168227
CORL47	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97923
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.836972
late endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6989-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90230495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20347
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K44481920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86992
A549_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131664
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A-Vietnam-1203-2004(H5N1)_2day-TNFRSF1BKO_None_GSE40792	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.66532
GTEX-WZTO-1026-SM-3NM9P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28444
FOXO1_01_322	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60149
TMEM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50244
B4GALT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04798
lung_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.53378
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14123
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.609
253J-BV cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
BRD-K72647169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20439
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6126
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51764
MITF	ChEA Transcription Factor Targets	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
TFCP2L1	ChEA Transcription Factor Targets	1.0	null
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GOS3	CCLE Cell Line Gene Expression Profiles	1.0	1.44142
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08675
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
developmental disorder of mental health	GWASdb SNP-Disease Associations	1.0	0.319107
BRD-K42081955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23268
GTEX-WFG7-0526-SM-3GIKI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930674
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.787097
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22279
Flexion Contracture	DisGeNET Gene-Disease Associations	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11082
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123759
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00373
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966625
Memory Disorders	CTD Gene-Disease Associations	1.0	1.42562
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985164
P3H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20436
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.25771
BRD-K09960817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77973
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.13537
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872074
HES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56893
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD63	Pathway Commons Protein-Protein Interactions	1.0	null
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.82716
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.541529
Superior olivary complex, periolivary region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2751
GPR120_KO_GDS4830_414_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SMAD1-26771354-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K81465091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0854
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06628
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37949240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06718
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02278
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT-1080	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.870062
Heart Diseases	CTD Gene-Disease Associations	1.0	1.25713
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer 4 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46134
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129152
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06936
hsa-miR-103a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K79090631_CGP-60474_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus subceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0312
Lucanthone_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237597
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01131
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03763
NFYA	ENCODE Transcription Factor Targets	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.183407
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21576
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76768
Brain Lower Grade Glioma_LGG_TCGA-HT-7602-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.69241
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152264
BRD-K97733472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20147
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CH157MN	Achilles Cell Line Gene Essentiality Profiles	1.0	1.68701
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
BRD-K00537235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89061
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SO-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC1SQ	DepMap CRISPR Gene Dependency	1.0	3.23214
GSE178255_2_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NNC 26-9100	DeepCoverMOA Drug Mechanisms of Action	1.0	0.57
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K43050752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10142
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51829
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59252
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6023
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22535
GSE146074_10_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Developmental and epileptic encephalopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
Tiagabine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
lysosomal membrane	GO Cellular Component Annotations 2025	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.38618
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.23865
Lung-macrophage	Tabula Sapiens Gene-Cell Associations	1.0	14.3909
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23694339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49031
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49001
TCF4	ChEA Transcription Factor Targets	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
42MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55422
BRD-K13089873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01927
PMC10313373-jci-133-164637-s072.pdf-18-TERF1_TERF1	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Superior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27162
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.6097
GABPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539251
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INCB 3284	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
Cortical Visual Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
WDR5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13803
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15078
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872484
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7253-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951045
IRF1	ENCODE Transcription Factor Targets	1.0	null
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.52813
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040624
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
targeting	GeneRIF Biological Term Annotations	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7854-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-519d	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
A549_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164373
SRSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77568
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36170990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21044
PPARG-20176806-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172816
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00843477
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2921
RELA	ENCODE Transcription Factor Targets	1.0	null
LU-135	GDSC Cell Line Gene Expression Profiles	-1.0	-1.74776
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43183
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25341
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12192
endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Presynaptic cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.71
A549_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102237
K562_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172646
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	2.50742
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE155031_6_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28349636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06067
endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047306
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13972
ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K12539581_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ceritinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.7
TFAP2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936664
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4828
BRD-K89397494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47229
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K37763427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8171
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00629
hsa-miR-4262	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
hsa-miR-4802-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.1212
GTEX-XPT6-2126-SM-4B66P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995634
BRD-K38035271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11491
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.33228
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19888
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28369
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32493
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.875033
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140968
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33622
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52640952_NP-004121_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.4188
PMC8752721-42003_2021_2991_MOESM4_ESM.xlsx-Fig3_E2F2-gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
Infertility, Female	CTD Gene-Disease Associations	1.0	1.10424
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Zaltoprofen	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hsa-miR-20b	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
BRD-K17231179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08785
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PD173212	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554623
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31399
hand	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.13856
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28394
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAPAN2	CCLE Cell Line Gene Expression Profiles	1.0	1.58399
Rifaximin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
amygdalohippocampal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10277
CXCL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37218
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.871877
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51505
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.03184
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214923
BRD-K47443098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14155
Megestrol_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0348591
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
BRD-K81131499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00482
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25763
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30510226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62583
Meloxicam	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-0.985641
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ventrolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0246
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bladder	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28176
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06519744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37973
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1868
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.15194
6720_PRDM10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.56149
PKLR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00994699
Brain Lower Grade Glioma_LGG_TCGA-HT-7620-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.89385
CEBPD	ENCODE Transcription Factor Targets	1.0	null
PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pentoxifylline_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0106204
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50172
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186835
MCF7_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110302
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56548
protein modification process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7482-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61560971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92406
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32493
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162272
BRD-K50004365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08314
FOS_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.83858
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46067
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.863433
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.379
CREB1	ChEA Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48451
hsa-miR-369-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
hydrocortisone_homo sapiens_keloid scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41117
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.891257
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162276_2_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977681
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PACSIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670086
Nasopharynx epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
TROAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88963
GTEX-XMD1-0011-R10A-SM-4AT4A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08671
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74879991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63253
hsa-miR-202	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
BRD-K04631545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53912
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14001
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5152
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5874
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19981
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.933533
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	1.61466
BRD-K44797534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72234
ZNF26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23048
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500656
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XGQ4-2526-SM-4AT57	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08773
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84685162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83039
Whipple's Disease_macrophage_GSE16180	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.29207
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2025
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7066
obesity	GWASdb SNP-Disease Associations	1.0	0.790534
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.571543
BRD-K86817746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09863
NCIH2342	CCLE Cell Line Gene Expression Profiles	1.0	1.56736
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01512588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28606
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06749
Sarcoma_SARC_TCGA-DX-A2J1-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157233_2_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860803
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248281
22RV1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.83535
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38676
BRD-K85606544_neratinib_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40921
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51157416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20259
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08472
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SAP30	ENCODE Transcription Factor Targets	1.0	null
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40159
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18095
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
18614019-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
ERK5-IN-2_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0112728
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Adrenocortical carcinoma_ACC_TCGA-OU-A5PI-01A-12R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OIZI-0426-SM-2XCEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74852
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.189222
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.604965
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
Hernia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922272
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3143	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
BRD-K99252563_QL-XII-47_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92353
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
r6 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03246
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22215
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Cytarabine (hydrochloride)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0159943
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of body weight	GWASdb SNP-Phenotype Associations	1.0	0.341468
Perturb_8012_KD_Ddx3_SRP324914	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.01687
satellite cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.578416
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055307
BRD-K14122415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27806
BRD-K54751614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1824
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.880324
Eccrine porocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.896
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
RGS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00687135
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.18816
Cabozantinib (S-malate)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0368621
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32193
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
OAW42	Achilles Cell Line Gene Essentiality Profiles	1.0	1.05937
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7524
insular cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12503
Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FTC-133	GDSC Cell Line Gene Expression Profiles	-1.0	-1.75123
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7902-01A-12R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32888
BRD-K05250921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03473
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8191-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K65883179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01271
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06147
REST_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
Vascular smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
A549_PHA-680632_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110688
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115468
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.26523
BRD-K09395335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63907
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243084
outer CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45204
1398_CDC37_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13331
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92969
MYOG_myocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9831
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827922
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190384,GSE190386_6_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76308
JUN kinase binding	GO Molecular Function Annotations 2025	1.0	null
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210579
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48557872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63709
Crizotinib (hydrochloride)_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0171665
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	8.6543
SJSA1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.33793
BRD-A31602150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.12636
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
UNC 0631	DeepCoverMOA Drug Mechanisms of Action	1.0	0.79
HNF4A	ChEA Transcription Factor Targets	1.0	null
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05657
Ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Macaque_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040601
GTEX-UPJH-0626-SM-4IHJN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2095
hsa-miR-1183	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Perturb_14144_KD_HK2_SRP322804	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.6943
basolateral amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37402
BRD-K34370545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16573
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851336
GTEX-PLZ6-0526-SM-3P61C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840241
primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837196
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245198
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2643
BRD-K17384993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0104
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
zinc acetate_homo sapiens_gpl570_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015009
ARL 17477	DeepCoverMOA Drug Mechanisms of Action	1.0	1.24
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.024971
PDLIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14445
BRD-K41389177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2385
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55784
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.852362
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859299
Protease-associated domain, PA	InterPro Predicted Protein Domain Annotations	1.0	null
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46501
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Vortioxetine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0100296
Microcephaly	DisGeNET Gene-Disease Associations	1.0	null
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26349
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5634
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.245323
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18493
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.942153
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K51897928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04265
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4639
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27663
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32377
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.952533
BRD-K89232006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30301
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59921
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12107215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16944
UBTF	ENCODE Transcription Factor Targets	1.0	null
ChIP_KLF4_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Benproperine (phosphate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176037
TM6SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33947
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865915
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054632
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.978012
PMC9376070-41419_2022_5157_MOESM15_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_of_CYTOR-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21708
BRD-K96788889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78598
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113636
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06842972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22462
Perturb_1385_KD_Zcchc8_SRP187429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.58995
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231799_3_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218398
A549_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153803
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17418_KO_Myd88_ERP115704	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.88894
GSK-1070916	DeepCoverMOA Drug Mechanisms of Action	1.0	1.91
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03677
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bicalutamide_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175395
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39263
5-Hydroxyflavone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
TP63	JASPAR Predicted Transcription Factor Targets	1.0	null
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87667
Oropharyngeal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149211
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989214
BRD-K75007044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.71321
hsa-miR-3922-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
MAFF	ENCODE Transcription Factor Targets	1.0	null
RPMI8226	CCLE Cell Line Gene CNV Profiles	1.0	1.38448
BRD-K50287215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15667
MYOD1	ENCODE Transcription Factor Targets	1.0	null
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3719
GTEX-W5X1-0526-SM-3GILH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962551
obesity	GWASdb SNP-Phenotype Associations	1.0	0.687222
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ5-1626-SM-3NB21	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972742
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VL-01A-21R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209269
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16728
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LHX1_NULL MUTATION - Ablation_GDS1748_748_mouse_Embryonic kidneys (from day E14.5)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
corticosteroid-binding globulin deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
A549_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022323
BRD-K39438085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2217
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26113
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6019-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33379087_tivantinib_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TRAM-34	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A56884981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15768
Poisoning	CTD Gene-Disease Associations	1.0	1.39226
T47D	GDSC Cell Line Gene Expression Profiles	1.0	1.57131
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863396
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.27775
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.919081
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00939024
arm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07618
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28617
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KCNS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00434481
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20352
glial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
drofenine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23004
recycling endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.601909
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01398
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59325
GTEX-XLM4-0011-R2B-SM-4AT5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18555
BRD-K76742876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04918
OSI-027	DeepCoverMOA Drug Mechanisms of Action	1.0	0.89
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.73958
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UN-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05957
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19175647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23154
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gedatolisib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.22
endosome membrane	GO Cellular Component Annotations 2015	1.0	null
neurological speech impairment	GWASdb SNP-Phenotype Associations	1.0	0.756753
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.8316
GTEX-WFJO-0326-SM-3GIL3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954738
MYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35413
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17420784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11043
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
imatinib_homo sapiens_gpl201_gds838	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K04546108_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173621
SCML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55062
BRD-K70276322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56742
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214832
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.849272
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01887
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29602
BRD-K38858314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21409
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08761
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16286
BRD-K64474460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19843
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0011-R2A-SM-32QOW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901967
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24346
BRD-K15654812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15721
PMC4383005-ncomms7500-s3.xlsx-Supplementary_Table3-Supplementary_Data_2_HES5_vs_HES5-_expression_intensity_ratios_during_NSC_progression_HES5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-93	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
PPARG	ChEA Transcription Factor Targets	1.0	null
BCL3	ChEA Transcription Factor Targets	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02179
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53181
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MDAMB436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98525
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.952972
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.3572
HDAC6	ENCODE Transcription Factor Targets	1.0	null
SW1783	GDSC Cell Line Gene Expression Profiles	-1.0	-1.87772
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74449
pipenzolate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13108
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.979349
CREB1	ENCODE Transcription Factor Targets	1.0	null
late endosome	GO Cellular Component Annotations 2023	1.0	null
GSE210580_3_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3160-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74889
A549_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014688
PANC0213	CCLE Cell Line Gene Expression Profiles	1.0	1.63991
MCF7_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141573
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.365
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38386
9-Aminocamptothecin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.8
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968484
Adrenocortical carcinoma_ACC_TCGA-PA-A5YG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2025	1.0	null
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46205
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049195
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55328
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.560142
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12526
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27600134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49114
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
KLF4-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RIMOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35022
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.14541
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979014
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175788
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NRSE	MotifMap Predicted Transcription Factor Targets	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of higher mental function	GWASdb SNP-Phenotype Associations	1.0	0.41103
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2464
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37726
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68174511_torin-2_SKBR3_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53688
UBE2E3	Pathway Commons Protein-Protein Interactions	1.0	null
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.934221
AsPC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38636
BRD-K69437108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07104
Sunitinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00759703
REST_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14111
ubiquitin protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
JIMT-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.49065
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55435
CTDSP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30125
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2HX-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUS-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-181a	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128807
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18450603-Table3S	GeneSigDB Published Gene Signatures	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.8556
BRD-K40306365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30617
MDA-MB-468	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.839903
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14374
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895045
TERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33966
BRD-K24076516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9423
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151127
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954168
ABC-1	GDSC Cell Line Gene Expression Profiles	1.0	1.45525
REST_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leukemia_chronicMyelogenousK-562	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08064
Neoplasms	CTD Gene-Disease Associations	1.0	1.44681
Adrenocortical carcinoma_ACC_TCGA-OR-A5JQ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9362915-pone.0272017.s004.xlsx-Day5_-0_7_Top-BBX_BBX	Rummagene Transcription Factor Associations 2026	1.0	null
263_ALG11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46528
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Developmental and epileptic encephalopathy 73	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.638
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99818283_PIK-90_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3675-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77940693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55025
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9205
BRD-K70148257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33196
SCH 58261	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
SARS-BatSRBD_Day7_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.98384
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5360-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142772
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in posteroventral (inferior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15376
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6384
NFIA_Deficiency_GDS2775_640_mouse_Postnatal brains (at P16)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3607232-mmc3.xlsx-b_RUNX1_SEM_MLLC_H3K4Me3-x_2_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4171
ntera2	HPA Cell Line Gene Expression Profiles	-1.0	-1.01019
A549_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162335
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05721
STAT3	ENCODE Transcription Factor Targets	1.0	null
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
GTEX-XGQ4-1526-SM-4AT6H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857018
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34892
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Indapamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
MOLM13	Achilles Cell Line Gene Essentiality Profiles	1.0	1.3675
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.919962
GJA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487491
BRD-K62885083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79604
SERINC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92682
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88296
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1024
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0103
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-11A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.70716
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2973-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173
Brain disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.789397
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.061652
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Topiramate	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204371
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17134
IZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00539
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03786
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131557
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC7A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00347729
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903873
GSE102269_3_v_0_clpp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0226-SM-2XCA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835603
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
Short Lower Third Of Face	DisGeNET Gene-Phenotype Associations	1.0	null
Pictilisib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.22
temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
lateropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68496
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998746
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBE2D3	Pathway Commons Protein-Protein Interactions	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146608
OAW-28	COSMIC Cell Line Gene CNV Profiles	1.0	2.49065
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKT1_knockdown_141_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.22082
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53732
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TT	CCLE Cell Line Gene Expression Profiles	1.0	2.16795
ALL-PO	GDSC Cell Line Gene Expression Profiles	-1.0	-2.46434
A549_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162948
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A90249268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43546
Perturb_9539_KD_Utx_SRP066186	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
15474998-tableS1c	GeneSigDB Published Gene Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7422-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09217
astroglia	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160512
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35833
MARK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728273
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ubiquitin-like protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
A549_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181854
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64993
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00906
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060744
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214954
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22971
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.66212
BRD-K42247636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59974
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48421
primary auditory cortex (core)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03082
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-8693-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53613
U2OS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33576
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38123
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal sleep behavior	MGI Mouse Phenotype Associations 2023	1.0	null
GSE234647_1_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180197
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.759053
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS11	DepMap CRISPR Gene Dependency	1.0	3.32032
Lung squamous cell carcinoma_LUSC_TCGA-66-2737-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290907
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146156
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20302
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57756
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72155
BRD-K82685933_BTB06091SC_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.56435
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06211
CAMA-1	GDSC Cell Line Gene Expression Profiles	1.0	1.43431
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.633
GTEX-OHPK-1726-SM-48TC4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0007
Folic Acid	CTD Gene-Chemical Interactions	1.0	null
ARX_KO_GSE12609_3_mouse_brain (subpallium, Pou3f-expressing cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN011_HEPG2_24H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10127
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055461
2796_EXOSC9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.814922
hsa-miR-4419b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162233
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97134
chr3_149958272_G_A_b38	GTEx eQTL 2025	1.0	1.73543
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018185
r3 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13142
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02919
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052003
CHD1	ENCODE Transcription Factor Targets	1.0	null
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17047
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47022
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16858
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250338
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTF2A1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20343
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13779
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K44520987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10934
GTEX-QESD-1726-SM-2S1R7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02374
Perturb_11627_KD_ERCC3_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.82954
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145474
layer 3 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02131
MCF7_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239588
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
U343	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.12566
L-Thyroxine (sodium salt pentahydrate)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0168521
A549_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029063
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72609445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28297
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Zinc finger, RING/FYVE/PHD-type	InterPro Predicted Protein Domain Annotations	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25835
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61523
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962148
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16352
HPGDS-In1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
Hypertension	CTD Gene-Disease Associations	1.0	1.47736
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.28549
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.363949
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.82544
PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11923
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983606
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88391
BRD-K44292107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37266
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12426
CUX1	ChEA Transcription Factor Targets	1.0	null
pyramidal cells of rostral CA4	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.894628
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3389_KO_Tcf7_SRP217200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.62952
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear membrane	GO Cellular Component Annotations 2015	1.0	null
endosome membrane	GO Cellular Component Annotations 2023	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01268
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.94378
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10687
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861088
layer 2 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48947
Artery disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.444
hsa-miR-499a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
golgi membrane	GO Cellular Component Annotations 2015	1.0	null
A549_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109409
K562_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151097
GSE111102,GSE111105_3_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
transferase activity	GO Molecular Function Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8106-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HOPX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18739
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleus of the trapezoid body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.48968
REST_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184367
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05648
6874_PSMD6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.64968
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19074
GTEX-R55C-0826-SM-48FCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917563
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytarabine_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0234387
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF4	ChEA Transcription Factor Targets	1.0	null
SOX2-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942981
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07079
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
No annotation - 31	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7486-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nod2_21335489_hek293_lof_human_gpl570_gds4416	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.088974
GSE108675_2_v_1_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79781106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06926
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5086
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71946
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27902
Clozapine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
A549_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017071
avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07241
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05003
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.07142
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045082
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.54306
SIK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52137
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04668
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MU-A8JM-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97741413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35213
ethanol_rattus norvegicus_gpl341_gse1996	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-1243	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.262
BRD-K91879432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50442
GTEX-WRHU-0626-SM-3MJFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08256
ATF3_01_33	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59594
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51406
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147396
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9499
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68977
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Q7-0426-SM-3K2BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04269
TGW	GDSC Cell Line Gene Expression Profiles	-1.0	-3.53712
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193999,GSE194000_1_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8430-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARalpha_OE_GDS2289_244_mouse_Skeletal muscles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PRR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00455
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.1663
endosomal part	GO Cellular Component Annotations 2015	1.0	null
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1782
GSE183335,GSE183351_3_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71514
Muscular Dystrophy_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE3252	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.87983
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40364
SCC15	CCLE Cell Line Gene CNV Profiles	1.0	1.41338
GSTA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77809
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21680192_mitoxantrone_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Specific granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
BRD-K88820027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24482
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0109196
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4647	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
k562	HPA Cell Line Gene Expression Profiles	-1.0	-1.38231
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4315
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09267
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9737
GTEX-VJYA-1726-SM-3NMDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05079
organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE111247_11_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77181307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30686
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.93133
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.92163
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885993
HIV - Human immunodeficiency virus infection_T lymphocyte_GSE6740	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.14811
RNH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28572
PRR19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33084
6858_PSMC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61336
finger	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.13988
protein kinase binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K29661539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13846
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08536
Methionine	CTD Gene-Chemical Interactions	1.0	null
MYL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68078
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHF8	ChEA Transcription Factor Targets	1.0	null
SB-222200	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52681
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955959
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8513
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298641
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Canagliflozin (hemihydrate)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0151061
MDAMB468_BREAST	CCLE Cell Line Proteomics	1.0	15.0409
Neutrophilic myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K91513229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03735
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8215
(S)-(-)-Pindolol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0407
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.374
SCHEMBL5061501	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.54
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21965
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7601-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63742
AK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0068153
GTEX-WH7G-2626-SM-3NMBE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06624
hsa-miR-20a	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15079_KD_Ash1l_SRP354984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.03153
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87277021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13733
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163693
Lung squamous cell carcinoma_LUSC_TCGA-39-5019-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82517280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17429
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06363
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.941194
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040498
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.28765
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909514
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PH-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22602
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40073
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07824
SNU869	CCLE Cell Line Gene Expression Profiles	1.0	1.54157
BRD-K14863829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55827
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136563
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251806
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2805-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248698
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07429
Olfactory bulb	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.297
A361	BioGPS Cell Line Gene Expression Profiles	1.0	0.93181
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.79307
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A5-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1031
COV504	CCLE Cell Line Gene CNV Profiles	1.0	1.68745
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JAK2_druginhibition_168_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.835636
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8485
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2106	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83927
BRD-K35451051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80792
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03202
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCC1599	CCLE Cell Line Gene CNV Profiles	1.0	1.37455
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLR26	DepMap CRISPR Gene Dependency	1.0	2.18619
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.00868
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83495
SYM-2206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16504
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8517
Piriform area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17244
ChIP_KLF4_19030024	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
Olfactory lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.297
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.91846
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46972
MCF7_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133208
Intestinal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57239
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEWO	CCLE Cell Line Gene Expression Profiles	-1.0	-3.99892
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56276074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24965
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26471
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.068452
H3K9ac_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K30917841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2239
RH30	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83151
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SW1990	DepMap CRISPR Gene Dependency	1.0	4.65609
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38768
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K38248920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45266
diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Momelotinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.92
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C11orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21243
GSE210667_1_v_0_rfx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYBS-0326-SM-3NM8S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19515
reading disorder	GWASdb SNP-Disease Associations	1.0	0.863433
BRD-K60777422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07345
hsa-miR-17	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ingenol-3-angelate	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.88
BRD-K41033271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35934
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882578
Perturb_10256_KD_TP53_SRP346937	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.89779
SP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83106
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017662
NCIH2141	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45314
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Idoxuridine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188147
SNU503	CCLE Cell Line Gene CNV Profiles	1.0	1.78757
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.193
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014832
BRD-K24669989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1669
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE5	CCLE Cell Line Gene Expression Profiles	1.0	2.19106
ASH2L	ChEA Transcription Factor Targets	1.0	null
hsa-miR-4662b	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.0302
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.30026
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.661626
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.932686
GSE149903_6_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A3-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fluticasone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5516
BRD-K59658487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46628
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236332
16574658-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13903
BRD-K23166347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09308
protein ubiquitination	GO Biological Process Annotations 2025	1.0	null
MZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.940515
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273831
BRD-K10171338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1948
GTEX-TSE9-0326-SM-3DB82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51884
GSE210580_3_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7349_RNF13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.530948
Waist-Hip Ratio	dbGAP Gene-Trait Associations	1.0	0.153703
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.853422
Aprepitant_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02602
ranolazine_mus musculus_gpl1261_gse25767	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162108
Regulation of gene expression and mRNA processing - 2	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
A549_Resveratrol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123697
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.828884
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24408
PMC11839186-CPR-58-e13756-s004.pdf-61-RLF_RLF	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_VCAP_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70087673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27591
hsa-miR-181c	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97136
neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080272
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.284
Sweat gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
SYK_druginhibition_283_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.32418
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047987
spleen	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06494
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88081
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22222
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35251
Vemurafenib_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251366
GSE196117_1_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66774
S-isopropylisothiourea	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.338
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67682
DLG1	MSigDB Cancer Gene Co-expression Modules	1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00491
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96596828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69727
LN464	CCLE Cell Line Gene Expression Profiles	1.0	1.3916
Cecum cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A87Q-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12531
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43875
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JB-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
endoplasmic	GeneRIF Biological Term Annotations	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-655	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cyclosporin A_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0076713
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09129
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01148617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0855
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18205
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235511
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.835891
zinc acetate_homo sapiens_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-1197	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42918627_GSK-2126458_MCF10A_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52341452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57673
hsa-miR-4796-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.828403
Pt-K2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.995
intermediate stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14676
BRD-K61310138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6951
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28269
mantle zone of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24068
GTEX-SIU7-0226-SM-4BRX2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11826
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895914
JD-62-TK68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209373
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36509
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.553491
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30861
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00789
Fusidic acid_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0207767
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.06333
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CRCGN013_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2632
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982008
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.1294
Tassel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
THUMPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00864
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.70992
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SNU-C1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PRDX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37395
overnutrition	GWASdb SNP-Disease Associations	1.0	0.453618
MCF7_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152955
CHD7	ENCODE Transcription Factor Targets	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64268886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13138
Perturb_5967_KD_SUV39H1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.60669
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04779
KAT2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-POMQ-2026-SM-2S1OD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915573
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.03456
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.9906
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.833469
BRD-K41355409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54716
BRD-K96239538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08165
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEP135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04569
GTEX-W5WG-2326-SM-3GIJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37349
SP1	ENCODE Transcription Factor Targets	1.0	null
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0281702
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219607
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131744
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.63403
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21202
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10165
reticular nucleus of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48916
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE106130_0_v_1_grhl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.852028
ChIP_TCFCP2L1_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26113
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC202	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abducens motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20405
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26458
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8423
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9126
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23586
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231958
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K94014790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38416
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73363
PA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.902571
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.912166
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014617
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185554
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12582692-medi-104-e45093-s001.xlsx-Table_S1-Table_S1_Genetic_instruments_of_plasma_proteins_for_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4896_KD_NCBP1_SRP160510	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.52693
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24097
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
BRD-K73027631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46117
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Developmental Delay (Disorder)	DisGeNET Gene-Phenotype Associations	1.0	null
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49143
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0309524
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99043
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44217
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paragigantocellular reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02964
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010309
lateral part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08092
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101039
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7836-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15690866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41255
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.0
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.85691
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551078
BRD-K07534805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48613
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188382_4_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139802
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00801
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.673598
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058559
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38218
pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.671527
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	6.22035
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
16424041-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE131660_1_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05096562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23446
GTEX-XUJ4-1026-SM-4BOPB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19344
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69333
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.094282
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12359218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32317
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139639
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6602
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QF-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162276_2_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.69888
basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
diethylstilbestrol_mus musculus_gpl81_gse1839	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_2_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
SAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14569
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Basomedial amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16838
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0501
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.569411
A549_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170419
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53131
Perturb_13169_KD_Ncor2_SRP060657	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.8268
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201941
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40544
FN3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00740111
BRD-K06569345_HG-5-88-01_HME1_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3171	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
BRD-K21672174_Ro 28-1675 ?_PL21_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47428
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930946
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
4657_CARMIL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.913863
NUTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05111
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26653
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Postsynaptic cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.98
golgi apparatus part	GO Cellular Component Annotations 2015	1.0	null
osteoclasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.33283
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.06763
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Agranular insular area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33856
hsa-miR-4684-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31732
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31383
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.39628
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.997494
BI-3406_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0274179
E2F4	ENCODE Transcription Factor Targets	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKMEL2	BioGPS Cell Line Gene Expression Profiles	1.0	0.836474
ZBTB33_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-8200-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049796
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4429
Delayed Myelination	DisGeNET Gene-Phenotype Associations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.83301
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3853
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32529
GSE153341_2_v_3_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55362
Fedratinib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.4
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03498
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.53137
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24904
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12465
nuclear inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.846532
regulation of JNK cascade	GO Biological Process Annotations 2025	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3671	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
BRD-U08759356_EI-346_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE101239_5_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25865
FOS_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	1.60537
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177234
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35625
BRD-K85951787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54359
Pseudomonas Infection_Lung Tissue_GSE923	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.33413
BRD-K09863466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11123
Basomedial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03373
BRD-K01787291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8049
BRD-K34110797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40312
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123888
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19164
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-S7SF-2126-SM-3K2B2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62817
PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP	Rummagene Transcription Factor Associations 2026	1.0	null
FXYD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11491
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54334
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04151
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.831075
Primary somatosensory area, unassigned, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01546
Lung squamous cell carcinoma_LUSC_TCGA-66-2795-01A-02R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31796953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11923
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63314
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177431
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48039
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TC71	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04181
PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_GSI_FC_1_3_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
SP2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0128
Perturb_6035_KD_MBD3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.15566
astrocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4753-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JHH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48773
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02474
MCF7_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017969
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93743
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Medial longitudinal fasciculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
colo320hsr	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.676
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.73543
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825385
mRNA_POU5F1_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150509
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11634
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I1-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5929_KD_MBD3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.30033
Demeclocycline_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0150555
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.11175
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827231
excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05464
Cloxacillin (sodium)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0192956
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46505
endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
TAE 226	DeepCoverMOA Drug Mechanisms of Action	1.0	0.87
Fetal Death	CTD Gene-Disease Associations	1.0	1.4449
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60846
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vacuolar part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29657
PRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00434678
BRD-K38097136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97521
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.957558
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.12148
BRD-K87412446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09952
PMC9314667-Table_1.xlsx-Regulons-SOX10_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
Ozagrel	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GTEX-QDT8-0926-SM-32PL2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986345
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
6865_PSMD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512224
A549_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104158
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166933
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tucidinostat_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0285183
BRD-K28039328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63704
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61477
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GSE213219_2_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48211
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950164
496100537_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27757
PHF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03676
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ICG-001	DeepCoverMOA Drug Mechanisms of Action	1.0	0.72
BRD-K38510068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53535
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0308
SF172	CCLE Cell Line Gene Expression Profiles	1.0	1.46551
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018775
NANOG-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212182
nuclear	GeneRIF Biological Term Annotations	1.0	null
PCI15A	DepMap CRISPR Gene Dependency	1.0	2.24059
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911298
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10222
BRD-K31936306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40485
BRD-K75514760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19965
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.61247
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.65928
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.986169
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.168259
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.18478
BRCA1	ENCODE Transcription Factor Targets	1.0	null
EGFR_drugactivation_20_GDS2146	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.0815
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7447
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45245
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174769
UNC2250	DeepCoverMOA Drug Mechanisms of Action	1.0	0.66
Prostate adenocarcinoma_PRAD_TCGA-EJ-7327-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	JASPAR Predicted Transcription Factor Targets	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.772
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCAS	DepMap CRISPR Gene Dependency	1.0	2.40981
BRD-K40982265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19735
BRD-K19103068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02784
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.971463
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3597
BRD-K14589361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58773
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3399
A549_Tozasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169458
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927874
BRD-K94697940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54745
MCF7_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139522
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.824772
BRD-K49577446_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014004
BRD-K24722502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43385
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3492
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.77352
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30787
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.67035
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43184
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.827445
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00312
TCFCP2L1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8078_SLC39A7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11953
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE184884_6_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.037687
REST_01_136	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.58691
Abnormal Muscle Tone	DisGeNET Gene-Phenotype Associations	1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965174
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.162546
RB1_KD_GSE50532_624_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
UBE2D1	Pathway Commons Protein-Protein Interactions	1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062471
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131547
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23539
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197322
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878063
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33940145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9767
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.8148
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247375
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.28518
GSE218580_1_v_2_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05402890_17757146_MCF7_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02584
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842792
Tertiary granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63118
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5882
Monocrotaline_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0269058
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2626
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97315
BRD-K96057608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29403
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30953
TRAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33028
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15777
JUN	ENCODE Transcription Factor Targets	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
increased body weight	GWASdb SNP-Phenotype Associations	1.0	0.687222
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
t47d	HPA Cell Line Gene Expression Profiles	1.0	1.08619
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46987
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52392
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02408
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047335
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.866698
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.877583
SOX9	ChEA Transcription Factor Targets	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00373
BRD-K13662825_dinaciclib_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A172	Achilles Cell Line Gene Essentiality Profiles	1.0	1.67212
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25362
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Aorta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218439
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE138815,GSE138817_3_v_1_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTF2H5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50237
GTEX-WFG8-0926-SM-3GIKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832044
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZD-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49583
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24052
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20028734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02212
NBI-74330	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11021
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11683
BRD-K21747676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52274
Lung squamous cell carcinoma_LUSC_TCGA-18-3412-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A64523751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18631
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.961415
neurod1_17630985_pineal_gland_lof_mouse_gpl1261_gds3000	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.02749
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
YAP1	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5619
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.846948
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77045
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MALME3M	CCLE Cell Line Gene Expression Profiles	1.0	1.46243
NS309	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
MCF7_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175119
18667080-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.15933
Transcription factor TFIIE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.154
KYSE270	CCLE Cell Line Gene CNV Profiles	1.0	1.9187
BRD-K89514545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11762
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HI-TOPK-032_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02727
MCF7_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182786
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7467-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K86722849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50152
hsa-miR-485-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01717817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82422
KLF4-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1257	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Tubular endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.346
MCF7_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152874
GTEX-OIZG-1026-SM-3LK5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00818
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
17555561-Table1	GeneSigDB Published Gene Signatures	1.0	null
BRD-A19037878_trichostatin A_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24563
Fluconazole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.22
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11895
sclc21h	HPA Cell Line Gene Expression Profiles	-1.0	-1.14077
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19814171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3242
TUBA1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00719088
BRD-K07409609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42792
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K40112492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37747
GSE139948_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNU899	CCLE Cell Line Gene Expression Profiles	1.0	1.66902
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.856275
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848874
periventricular stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70139
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917188
SF268	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.58389
GTEX-U3ZM-0426-SM-3DB73	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869752
Lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
chlorpropamide-144	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNRPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23243
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	3.76051
BRD-K30863464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11914
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0943
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56548
BRD-A59009217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90143
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210984
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32731
lateral superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21075
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
capan2	HPA Cell Line Gene Expression Profiles	1.0	0.973077
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.896611
BRD-K16047442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33073
CRCGN012_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36126
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26795
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Proteinuria	CTD Gene-Disease Associations	1.0	1.30758
lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27591
Cortical subplate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07836
17676974-TableS1	GeneSigDB Published Gene Signatures	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78981
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HL-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53677
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010854
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98153780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46218
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.79544
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07202
CAL-39	GDSC Cell Line Gene Expression Profiles	1.0	1.58967
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204608
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49556
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00532
RARB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492042
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039211
pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.476772
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0426-SM-3DB8X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85711
SRF	ChEA Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945095
MYBL2	ENCODE Transcription Factor Targets	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83013052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17194
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880259
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_EED226_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122169
lateropallial prepiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27516
15489324-TableS2	GeneSigDB Published Gene Signatures	1.0	null
NR3C1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193949
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
myoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.32497
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55769
Hypoplasia	DisGeNET Gene-Disease Associations	1.0	null
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PCI6A	DepMap CRISPR Gene Dependency	1.0	2.8799
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173618
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17495
L363	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.1586
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A93436351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34848
GTEX-VUSG-0926-SM-3GIK6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846679
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SB-224289	DeepCoverMOA Drug Mechanisms of Action	1.0	1.01
S-Adenosyl-L-methionine (disulfate tosylate)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0171717
BRD-K56739005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14633
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.719384
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015795
UACC62	BioGPS Cell Line Gene Expression Profiles	1.0	1.17518
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81651477_Parthenolide_PC3_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181733
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125493
CRAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19013
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-28	GDSC Cell Line Gene Expression Profiles	1.0	1.47115
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61481
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A46747628_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.51004
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU899	CCLE Cell Line Gene CNV Profiles	1.0	1.56631
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966408
Lung squamous cell carcinoma_LUSC_TCGA-96-7545-01A-21R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-300	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887931
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.201335
BRD-K72050003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33721
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00342
PADI4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00737608
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE237812,GSE237813_3_v_2_hmgb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6795_PRPF38B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.593228
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.926877
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-02A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111903
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896734
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.7456
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09458
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46353
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.89359
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-767-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Perturb_11560_KO_BAX/BAK/BOK_SRP348085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Fr	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
BRD-K26263099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.78404
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09742
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22697
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052753
BRD-K43159427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70856
SMC3	ENCODE Transcription Factor Targets	1.0	null
znf148_21828133_erythroblast_lof_human_gpl571_gse31092	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.581759
SNU626	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44979
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Piriform area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36875
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15024
BRD-K93248080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44053