association	dataset	threshold value	standardized value
PTK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38169
GBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22331
KDM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37442
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6617
MKRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09505
MLH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72213
PUS7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8546
SBK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79252
MON2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74867
SRSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9166
ZNF74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31935
CTAGE6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9923
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50877
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0059
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11769
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASPHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50737
TMEM191B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16763
XXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.704
NAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19063
RDH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4565
EMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.6493
HMBOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29795
CPTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60589
ZNF846	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5185
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5626
ARRDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29243
ZNF384	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20175
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.38029
TMEM209	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1705
ARHGDIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99349
AHRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79491
JPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21551
TBCEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85879
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H4C16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93741
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99969
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89371
CFAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65209
GSE109530,GSE109531_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.637
PPP1R3E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84351
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KDM4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04613
GSE188721_2_v_1_mesp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222188
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6305
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
NUPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57271
CDC42SE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37583
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2465
ACLY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37287
IGFBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05088
TMEM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12811
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289963
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PADI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40118
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.698
CDC14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12315
ZNF100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91008
TOX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64595
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CPSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56669
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MEAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.299
MAPKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37815
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TUB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55289
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BLM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23343
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KBTBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67722
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.65145
JAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0265
LEFTY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49751
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6806
KCNJ14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37215
GSE133213_10_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_2_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF507	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59557
UBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48348
CTCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23693
COX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29694
THAP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76982
SNX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86638
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6976
GSE128076_1_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCORL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65478
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78109
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7003
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADAM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68283
CKS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4759
NAMPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38611
FUBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10576
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53244
PSME3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16989
RPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11552
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.791
HGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71978
ZNF761	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22225
CYP51A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5432
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MTSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39951
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465785
RSRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20986
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11524
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29703
AMOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68714
TSHZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75582
SH2D3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36544
GSE210662_2_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5886
CUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51862
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.8556
ABL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20406
CDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25996
GALNT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97123
GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82219
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51796
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ASCL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03841
CD2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59837
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RABEPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06907
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.0054
PRR36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80395
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU3F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85117
SLC66A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33752
JB-23-ZE86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22436
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAB6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3199
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0412
KAT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82403
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CLCN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44025
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS6KB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62361
BICDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45686
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7159
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260255
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288568
TXNDC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01776
SLC2A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45229
GSE174418,GSE174421_0_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80999
CAPZA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.75392
CB-62-TB77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210544
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDC37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45273
CREB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25598
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17025
UBR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47445
ICE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48102
PNCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68804
MFGE8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50723
SREBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15328
EIF4ENIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77114
RAPGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45106
PEG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46346
TEX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40798
SUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43833
ARHGAP45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42261
TBC1D25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24275
MAGEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26807
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7147
GCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53504
DENND4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53945
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.027
SLC45A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20552
ZNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.96724
HTRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51903
LRRC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56517
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PDPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70734
GABRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88644
ADM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78994
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11143964-jciinsight-9-161356-s009.pdf-23-MTERF1_MTERF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4327
PINLYP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66145
HSPA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86257
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88741
RAD23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77097
TRMT10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72682
WDR83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86326
UBE2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06408
TMPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40155
TDG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49276
GOLGA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38285
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
HACD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56466
GSE197532,GSE197533_0_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88274
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74786
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
PATL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67096
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2025	1.0	null
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAB9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69942
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MED29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14503
GSE192663_1_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TIMM8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55384
GSE184133,GSE184137_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38255
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF469	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9927
CRLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8717
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.0481
SALL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82052
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88654
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C19orf53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50049
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ACSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75336
ACAD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69093
BEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00846
ARL4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56362
ZNF558	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23438
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310277
KDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19603
ANKRD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52542
S100A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70758
RAD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2047
CPXM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79857
PMC12439337-thnov15p9091s1.pdf-87-ENSG00000162702_ZNF281	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
DHTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44952
TNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58718
CD151	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07706
ZSWIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67919
MAPRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46468
PEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59018
P2RX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01295
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257322
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249364
ATP2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48239
FOSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.72191
ZFAND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31598
ZNF311	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98915
GIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20674
RFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19114
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
L1TD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2922
MAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67604
CSTF2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05404
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209108
TEAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19585
GABARAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61522
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1415
ENTPD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72628
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318166
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212804
PMC11462941-CAS-115-2947-s001.pdf-100-MBD2_MBD2	Rummagene Transcription Factor Associations 2026	1.0	null
RTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21441
MTFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6721
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5185
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
EIF4EBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94687
HPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7377
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252051
NSMCE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16921
ITGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43173
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0677
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CFAP410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96454
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0664
H2BC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29002
LZTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9996
KMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96041
CDYL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0309
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86423
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65988
GLCCI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58724
SIX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35075
GPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72033
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
APPBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04482
RXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92334
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206873
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275542
LSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.635
CENPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05935
YIPF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43424
ZSCAN5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66361
GTPBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6003
PMC7833686-mmc5.xlsx-e_q1en30_v1-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72195
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46146
TMEM258	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3386
ZFP36L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28271
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00945
KCNQ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40428
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06251
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SMG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65944
CD177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56563
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCEANC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31603
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14261
LEFTY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61054
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZMIZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75013
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DYNLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19432
TRIM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85581
MATN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28648
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TRUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89187
FRMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37724
PRRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82013
SEC31B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25044
STMN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47046
EID2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39032
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EEF1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26535
NFE2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9158
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74179
NBPF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32542
FABP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01692
CAMKK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43613
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM170A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97593
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03275
PRDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01378
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RHBDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29851
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281753
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94505
KLHDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22813
FAM53B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98029
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2836
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLAIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58844
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212444
DBF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52203
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128076_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87705
CREB3L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8039
NANOS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61707
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.698
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TSC22D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33169
GSE131903_0_v_2_abca12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396166
PI4K2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78769
ZNF83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08702
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03412
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43921
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98647
ALG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52304
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PDS5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78285
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MMP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17802
PMC11266547-41598_2024_67808_MOESM1_ESM.pdf-48-ENSG00000171649_ZIK1	Rummagene Transcription Factor Associations 2026	1.0	null
DEF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17436
NR1D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10062
TACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42344
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
SSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92718
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C3orf38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80225
C1orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69959
OSBPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5914
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1258
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNAPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80207
RNF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15428
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ubiquitin protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
RAPGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68867
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6932
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNRPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68044
H2BC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53031
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
CHTF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47092
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
THAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70616
KLHDC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75304
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BICD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95359
TYK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89744
CCND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87272
CBX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55518
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376018
protein ubiquitination	GO Biological Process Annotations 2025	1.0	null
EDEM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36973
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204342
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2894
CE-20-VA70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209757
C12orf57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66389
ARHGEF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22181
COX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1458
DPYSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61494
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1957
PMC11266547-41598_2024_67808_MOESM1_ESM.pdf-48-ZIK1_ZIK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CALML6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33064
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76832
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RHPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76349
SMPD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93305
MGST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40124
ERVMER34-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82378
GSE245134_0_v_1_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38228
HIKESHI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38594
RNF181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36481
BOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92282
BAZ2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73337
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39934
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCARB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12299
PRCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53395
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6384
ZNF530	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55311
S100PBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06672
BTAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39635
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4041
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29385
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1966
ERO1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35691
EMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02959
HIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77327
GSE179868,GSE180330_1_v_2_ddx21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE74528_0_v_1_trex2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145915_3_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GPR63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92711
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28571
PABPC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.64871
H2BC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38932
ULK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67725
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268576
ESYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65375
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MNT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5248
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348165
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0304
MRPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93638
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20489
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BYSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08968
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234582
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.2401
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5868
PMC11522423-41598_2024_76982_MOESM1_ESM.pdf-41-CARF_CARF	Rummagene Transcription Factor Associations 2026	1.0	null
KIF18B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11651
ERP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34513
SNURF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89246
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188721_3_v_1_mesp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9645
CNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77791
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QRSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34554
SVBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72303
CSRNP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52489
PCSK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31487
SERPINB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98646
CAVIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00768
PCTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42512
ANKS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64123
GSE236072,GSE236075_2_v_1_ccr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GPR89A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92025
SLC39A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89245
PDE6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4209
CYB561D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99363
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCDHB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08163
GSE160817_4_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100316_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TXNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36776
CDC14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58124
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RSBN1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47025
ZNF596	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33514
SLC5A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68375
PCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39696
ATP5PF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46193
STK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46622
CTAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30688
CHRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84434
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DIDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83883
HBS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67484
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2013
FBLIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20109
GSE128076_2_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
NUP133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35876
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35796
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43835
CHMP4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19359
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	241.657
FBXO48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55953
BHLHA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67896
TBC1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49683
DLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63467
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248266
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7083
ZKSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84941
KDM5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40401
VIPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18466
GSE239578_5_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0316
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2042
ZNF709	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50795
LAMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52748
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48598
ZSWIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60299
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.294
KLHL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94119
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25229
ZHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70207
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203547
AR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41344
MRPL43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95928
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03709
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.5033
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF649	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17967
SAMHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9993
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.05957
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8147
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBPMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8037
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF585B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69488
PTGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30306
U2AF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91895
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157894_2_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58344
FUCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7411
HTR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57928
FBXO31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.42641
PDCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82919
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHLDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88702
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
CEP57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12064
CDC37L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68259
ATP6AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64522
NUDCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10865
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC27A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84733
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50525
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF680	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.577
PARP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47454
TOMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55319
DNAAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68526
TDRD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16568
PRRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69979
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377535
KIAA1671	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73023
EZH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85496
RND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20537
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2141
NCAPG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99011
KCNK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5931
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82437
CPSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95285
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5371
TDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66024
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-74-PJ26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2371
NCOA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5654
CACNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98866
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TARBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77044
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RGPD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33528
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5302
FUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96947
TRIM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36486
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IDI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66847
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
XPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72455
KLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32364
COL8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47628
ZNF420	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4481
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91138
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAGED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22136
SIGMAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14212
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7096
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C7orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61877
H4C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28202
TCEAL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55393
ENTPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47149
TRIM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47735
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MGRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33739
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9562
GSE98755,GSE98756_3_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204617
CHCHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20336
RGL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78106
MAP1LC3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64058
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
ZNF408	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37063
SEPTIN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68569
ARHGEF35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28593
E2F8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39577
ZNF85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05247
SWSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87919
ACOT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46338
SLC15A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54836
TMEM94	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05046
ZDHHC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32207
PYGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20974
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MOB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46945
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233102
ZNF653	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31701
ZNF853	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47111
GNA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69803
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TUBB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7536
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44319
ZCCHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35978
PPP1R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1194
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3527
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.3117
HCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92884
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0934
RCOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78645
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RALY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39686
DF-00-BX35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226828
TBC1D9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06743
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31643
MINPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15663
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38198
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC15A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22544
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1665
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PYDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26057
WDCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45193
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
NDST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.508
KCNH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12246
RAB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90802
TBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35593
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HE-16-PO98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216694
BBS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63317
IQGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88009
DMRT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79667
CC2D1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61403
MB21D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65918
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335706
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1161
ZNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56121
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	133.233
GMEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49397
MED26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.589
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70284
SHOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02157
HOXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57349
LAMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45156
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.2716
CXCL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02591
AF-30-GH67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.389724
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06686
DR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66949
TRIM39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60757
CDK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96296
SCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93853
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFB2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82784
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203433
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.4179
SLC45A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81755
ZNF404	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37638
SNAP47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23255
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55568
EXOC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51413
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ASB16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58364
H2AC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.88283
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2172
HOXC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47685
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44275
SLITRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73152
ACAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06862
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PSMB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08615
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
FDFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2566
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304246
ASB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5895
RAB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19711
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.87
NKX2-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27229
NIPAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86076
SAP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87156
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.698
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16476
PDE6D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85547
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63727
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C2orf68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9282
SKIDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02125
GSE156978_1_v_0_dnmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239457_1_v_0_rasa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ITGA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31226
MATR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7278
NGLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69444
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387447
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0973
ZIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44636
COL27A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84243
KIF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47239
TCEAL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03628
COCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98995
IQCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87015
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ANKRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34717
NREP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79479
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7931
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF385C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37374
SUN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48509
RIPPLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62732
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NUMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80672
GSE128076_2_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
SBDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87012
GSE144919,GSE145177_1_v_0_dazl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLEKHA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23718
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LIPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85294
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9213
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PDCD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71534
PCSK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98768
DDX42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37563
COX7A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16021
ITM2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73008
RNF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38394
DNAJB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03719
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57663
GSE203158_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483039
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8638
USP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73945
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381685
PDCD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18869
BRPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86667
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF525	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60063
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.825
NF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86499
MBOAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38034
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
ACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34004
NDUFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0536
CTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37441
GSE246461,GSE246463_5_v_0_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein modification by small protein conjugation	GO Biological Process Annotations 2025	1.0	null
RNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60827
HYOU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76707
CAVIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84996
PRDX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51208
H3-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31473
RPL28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68985
FNBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55131
CD37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44852
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
SLC2A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.97691
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSDMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02334
NDUFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20536
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
PLD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94431
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6193
DSEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63828
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HPRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07963
PMC11522423-41598_2024_76982_MOESM1_ESM.pdf-41-ENSG00000138380_CARF	Rummagene Transcription Factor Associations 2026	1.0	null
TP53BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36172
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.698
FLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74121
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11390959-41598_2024_70075_MOESM3_ESM.xlsx-520_DMD_common_down_gene_list-HES4_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LLPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64776
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.718
GAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11656
CCDC93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.72687
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18501
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RIOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14777
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ARL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81051
BORCS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36736
ZNF879	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26692
GSE184399_0_v_3_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCIDAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28201
TSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62746
MIIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26958
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396282
CDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48134
CTBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33791
GADD45GIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34631
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230744,GSE237803_0_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
EEF1AKMT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48368
GSE124048,GSE124067_1_v_0_irf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SEC14L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19325
ZBTB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15133
LYRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59958
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MFAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30664
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72461
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26647
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30425
SEMA3F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75669
SOX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93574
DHX38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
KDM6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73208
PMC9038526-mmc1.xlsx-postCOVID_LPS_vs_healthy_L-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FGD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80797
ZNF791	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84167
GSE205291,GSE205292_1_v_3_drd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TPD52L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06997
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF862	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.118
ZNF99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.70835
DAGLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70395
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85372
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316372
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44238
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200433
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HILPDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39002
LMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06828
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2BC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55219
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NR2C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69322
AVL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15831
HMGCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81585
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KCTD19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10601
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288012
RND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02787
PRDM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51435
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DAB2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52695
PAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23902
Neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
NMRAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7098
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
KLK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83768
KEAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08859
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17448
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CIDEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73519
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271485
ZFPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22927
TNFRSF11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87197
ZNF679	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06558
BECN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10751
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.0555
DNM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81683
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
PNRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2445
RFWD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39708
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF485	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.86183
STRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03989
ARNT::HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2212
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49129
PYCARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73455
B4GALT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60826
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06925
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RGMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10718
DIAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22831
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.217
NOP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46622
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39036
RIMKLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73607
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77138
SPG21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05892
TMEM125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.896
GSE149880_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PRR19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86685
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ALDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85758
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93901
NET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93778
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87155
PRKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28303
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
PCDHB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55891
PDCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27392
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
METTL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8065
CREB3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86677
SNAPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43787
TLCD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18018
UST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8632
KCNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00526
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7598
GLIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88137
BARHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29364
HNRNPLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10607
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265023
H1-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99308
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24521
ZNF705B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89438
TMEM69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57438
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CASC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92679
H4C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66766
H2AC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07012
EEF1AKMT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73797
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5763
GSE191105_0_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67397
ELAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07417
FZD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75645
USP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64339
GLO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86257
PMC12909843-41467_2026_68388_MOESM4_ESM.xlsx-fig3g-up-regulated_gene_expression_in_OTX2-KO_8CLCs_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
RILPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21253
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
H1-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8093
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CARMIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51432
KAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04612
MYO10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02873
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
CHAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44451
GSE118077_1_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE244199,GSE244200_0_v_1_chmp5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59108
PABPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93824
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VAMP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52857
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
FERMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45007
TBX22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84062
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1034
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56027
GSE149124,GSE149128_3_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06481
MVB12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38688
CCNDBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42455
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DHX29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45078
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69586
CHCHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37181
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VAT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85994
TTC38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46131
GPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46736
DDX53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27041
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46407
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90065
ECSIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89838
CDC25B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66565
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31332
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71087
PBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61513
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.669
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66308
ZBTB7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06517
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC38A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54366
APLP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03241
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0827
KIAA0930	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53746
GSE230263,GSE230265_5_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNAJC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41909
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247538
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35201
KCTD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07083
TGFB1I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33031
CNPY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19823
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TUBGCP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10734
ZNF101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58361
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50325
CYRIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49384
PMC12852376-SupplementaryFile1.xlsx-Supplementary_Table_S4-Analysis_of_the_association_between_QTL_and_iridocyclitis_using_MR_and_SMR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGEF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48697
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0375
GSE120612_4_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF777	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32551
DNAJC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37844
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7403
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85229
MAGI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71159
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SEMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05634
GSE86507,GSE86509_3_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARHGEF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30083
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NDST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44154
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2956
PUM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46478
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3125
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.044
ZKSCAN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55312
GFY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88334
PELI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58757
ARID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33191
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218853
PHOX2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02817
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289187
MTERF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.22479
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03051
RPS26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72374
H4C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28834
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.42
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65264
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05884
NRBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34421