association	dataset	threshold value	standardized value
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16801
USP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27752
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.054236
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929917
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897587
BRD-K46348476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68568
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.83795
SK-MEL-30	GDSC Cell Line Gene Expression Profiles	1.0	1.75504
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Olfactory tubercle, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12562
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.03628
XE-18-BC97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330099
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12817
TBC1D22B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21975
PCM6	CCLE Cell Line Gene Expression Profiles	1.0	3.04254
ion binding	GO Molecular Function Annotations 2015	1.0	null
CTCF_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
VMRCRCW	CCLE Cell Line Gene CNV Profiles	1.0	1.61037
Autoimmune disease of musculoskeletal system	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.054
BRD-K43025624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34463
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9147
HCC33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5738
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22573
Lung adenocarcinoma_LUAD_TCGA-44-6146-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase	InterPro Predicted Protein Domain Annotations	1.0	null
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4273
GTEX-QDT8-0011-R6A-SM-32PKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23043
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dorsal column nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6579
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42436
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81217407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28992
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41201
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39594
BRD-K43364707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07747
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R0-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.667964
GSE193624_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vincamine-3865	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8415-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37516
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.906903
BRD-K11502669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4886
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44026
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247537
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.980603
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.36705
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mean platelet volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	10.0
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.521667
BRD-K01237277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09751
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lomefloxacin-3620	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE179031_3_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.990006
bipolar disorder	GWASdb SNP-Disease Associations	1.0	1.00407
GATA1	ENCODE Transcription Factor Targets	1.0	null
H1_BMP4_Derived_Mesendoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.868079
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15012
layer 2 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09104
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.83024
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT1080	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.17766
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1618	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58024
4158_IP6K1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.650286
CRCGN014_HEPG2_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01363
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX9	ChEA Transcription Factor Targets	1.0	null
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15137
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962696
Acute Myeloid Leukemia_LAML_TCGA-AB-2932-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HL-7702 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09277
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47558
bronchus	HPA Tissue Protein Expression Profiles	1.0	1.5636
SAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38779
Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parasolitary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70923
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902978
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.15339
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KELLY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65082
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GM133	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11798
PSMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44909
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.428681
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT4	ChEA Transcription Factor Targets	1.0	null
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22134
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855336
phenacetin-3992	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1979
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25849
Fatty Liver	CTD Gene-Disease Associations	1.0	1.23074
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4367
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.24212
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A08363225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3283
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00488
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05705
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3689a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
NCI-H2141	GDSC Cell Line Gene Expression Profiles	-1.0	-1.73894
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922669
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26359
BRD-K44864058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41973
AG-028671-6582	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08922
benzathine benzylpenicillin-4022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ankylosing spondylitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.054
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05175
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.661396
HCC1359	CCLE Cell Line Gene CNV Profiles	1.0	2.56118
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39419
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98075
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45451
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
UD-09-TN01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206186
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23434564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34865
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0331
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986965
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diethylcarbamazine-2394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4433-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4322	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
oxymetazoline-2278	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
procainamide-2618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20589
Lung adenocarcinoma_LUAD_TCGA-86-7953-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G402	CCLE Cell Line Gene CNV Profiles	1.0	1.64225
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF273	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71292
MCM3AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73081
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09574
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02334683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19039
Perturb_4939_KD_Etv5_SRP111429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.58245
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1184	CCLE Cell Line Gene Expression Profiles	-1.0	-2.69267
ZNF383	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74839
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35169
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548772
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982115
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22655
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.678615
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15014
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-1.18554
BRD-K77801455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10061
carboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4844-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59913
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47S-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAKI-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.84872
monocarboxylic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403183
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633967
BRD-K44944875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01805
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.05523
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20546
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-RVPU-0008-SM-3NM8B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916349
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14253
distribution	GeneRIF Biological Term Annotations	1.0	null
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
CHP126	CCLE Cell Line Gene CNV Profiles	1.0	1.83334
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04026
intermediate stratum of the PBC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19869
napelline-2522	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38379
nucleus sagulum, deep part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16965
nordihydroguaiaretic acid-1648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851402
MOSPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.454
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30195
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19073
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18026
TET1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92241728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47099
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
streptozocin-5836	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MC116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-79-TC61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500007
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2474
BRD-K41876347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19548
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29642
BRD-K18136154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5257
metoclopramide-2315	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Platelet Mean Volume Determination (Procedure)	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K57938735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52281
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142191
Perturb_13676_KO_Tcf7_SRP096347	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.88731
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.14334
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
15656903-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
SNU81	CCLE Cell Line Gene Expression Profiles	1.0	1.73278
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31418
GTEX-SIU7-0226-SM-4BRX2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13639
H3K9me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05065
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-3B-A9HO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825808
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.94865
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.80896
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04104
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT1-17558387-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.939108
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55063
dorsal spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27488
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16561
levomepromazine-4723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4188
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.842207
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.87326
ME1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54194
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.42493
rifampicin-4008	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	1.5636
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.24221
BRD-K14258088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60322
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44691
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.10047
ASH2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02403
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K79020643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6926
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05948
DE-28-BW67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275605
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01969
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-654-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
FE-29-XM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318173
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09236
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ChaGo-K-1	GDSC Cell Line Gene Expression Profiles	1.0	1.46842
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dihydrostreptomycin-5751	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RP1_KO_GDS1845_190_mouse_Retinas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PC14	CCLE Cell Line Gene CNV Profiles	1.0	2.2571
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16742
TRIM24_knockout_299_GSE19675	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.93464
Perturb_3770_KD_GLI1_SRP042158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC9314667-Table_1.xlsx-Regulons-FOSL1_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04429417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02056
Perturb_1499_KO_Ticam1_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.97822
High light scatter reticulocyte percentage of red cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.7301
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
N6022	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226537
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9404
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03115
BRD-K14695590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12004
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891832
PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-E_MYOG_binding_in_downreg-Unnamed_1_MYOG	Rummagene Transcription Factor Associations 2026	1.0	null
HOS	CCLE Cell Line Gene CNV Profiles	1.0	1.57767
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19972
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-148	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430368
MYCN	ChEA Transcription Factor Targets	1.0	null
stomach	HPA Tissue Gene Expression Profiles	1.0	0.904601
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5489-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73523821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07116
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	1.87782
BL1921 (KIAA1967)	NURSA Protein Complexes	1.0	null
oxolamine-4969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04005364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10538
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00362
MAF-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE252958_1_v_0_znf469_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVKATE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68551
JL1	CCLE Cell Line Gene CNV Profiles	1.0	1.61898
BRD-K73604422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40428
binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	0.754865
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.911284
4-hydroxyphenazone-1497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Crohn Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Perturb_4276_KO_Smad2/Smad3_SRP132215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.21856
placenta	HPA Tissue Protein Expression Profiles	1.0	1.5636
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
aminopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7751
LP1	CCLE Cell Line Gene Expression Profiles	1.0	2.68198
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50186
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964965
hsa-miR-4265	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
BRD-A59009217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26621
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.633354
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-09-XQ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225933
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1549
DCA_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16536
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XD-37-GI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206657
Embryonal rhabdomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-301b	TargetScan Predicted Conserved microRNA Targets	1.0	0.047969
6062_PAPOLA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597222
BRD-K61661017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35485
BRD-K60295429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01898
Melanoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
Sarcoma_SARC_TCGA-DX-A3LU-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71139459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03454
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.991156
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71771
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48987
vigabatrin-6314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pituitary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.37036
Cholangitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
BRD-K20798215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39764
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26127374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23365
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83845379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88784
unsaturated fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
lung_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.941345
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24682
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARGLU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82302
hsa-miR-4302	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE157594_5_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NI-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40935524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04344
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45978015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33209
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA4-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A20018680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61664
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293759
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16256
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02507
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ionomycin-871	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03649
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.87792
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33922
Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205540_2_v_1_phloridzin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92513859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74711
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19383
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18376
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
PPRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65122
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterior amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03639
GSE226452_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LGLL - Large granular lymphocytic leukemia_Peripheral blood mononuclear cell_GSE10631	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.44696
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583446
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12909
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34157
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55256232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16662
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0291
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45086
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NSC95682	DeepCoverMOA Drug Mechanisms of Action	1.0	0.51
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249869
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ranolazine_mus musculus_gpl1261_gse25767	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982846
PF-00562151-00-6863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78297750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09607
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267326
mantle zone of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01789
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Adrenocortical carcinoma_ACC_TCGA-OR-A5LG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
BRD-K37592272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14656
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K44536345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07702
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76444
GTF2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5896
CFAP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38816
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K06459664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24161
2225_UTP25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581148
Type 1 diabetes mellitus_pancreatic islet_GSE2254	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.50611
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vernakalant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23371
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.5295
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-1.06211
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4201
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30738
fulvestrant-1663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.02519
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41335
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A76905089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01601
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59861
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213165
Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood	GTEx Tissue Gene Expression Profiles	1.0	1.28145
testis_7d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.03359
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A6GE-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158197_6_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
phenelzine-3884	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fluoxetine-3314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0738
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPF38B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62085
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.21864
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24218
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-1231	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59117
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD3	ChEA Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	226.747
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYYR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97304
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23731
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91835
BRD-K25312635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05436
Immature fraction of reticulocytes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1699
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.68167
STAT1	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76889263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06093
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10-methoxyharmalan-1743	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sulfadoxine-5852	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32072
clidinium bromide-4499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32477
C9orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27149
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63951
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPNRTBM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61497
amitriptyline-6353	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31316
GTEX-VUSG-1126-SM-4KKZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907229
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11575
Perturb_5142_KO_Ring1a_ERP008873	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.22211
BRD-K42508877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57273
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05923
chromosome, subtelomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.638
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06005
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886463
GSE184087_0_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05923
IC-18-TY61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.53144
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	1.4098
PPP1R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62631
GSE223334_3_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ritodrine-2635	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
thioperamide-4675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35664
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65817
BRD-K68884923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16064
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nialamide-4347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99001
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877724
Perturb_7468_KD_ELL2_SRP136956	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.43406
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.914552
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38696
abnormal lymph node morphology	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K98953346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28003
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.87476
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.30216
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Finding Of Mean Corpuscular Hemoglobin	DisGeNET Gene-Phenotype Associations	1.0	null
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13286
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02775
molsidomine-2862	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNB75	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.999939
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240291
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30772
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE148494,GSE182513_1_v_0_hoxd13_human	RummaGEO Gene Perturbation Signatures	1.0	null
Phosphatidylinositol 3-kinase complex, class II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.826
FOXC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68254
BRD-K00537235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21344
intermediate part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02061
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29112
Acute Myeloid Leukemia_LAML_TCGA-AB-2851-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ritodrine-5680	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bile duct disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868492
SW1088	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4843
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66964
PCDHB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12418
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OVKATE	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35835
CRCGN009_HEPG2_24H:B05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01515
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3108
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0809
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
carbamazepine-835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
4299_KCNMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.716415
BRD-K69872823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56271
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:F04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8325
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56068
GTEX-QMR6-0011-R7A-SM-32PKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25213
Perturb_6750_KO|KD_IER5_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.76115
psych	GAD High Level Gene-Disease Associations	1.0	0.295739
PMC12753515-Table2.XLSX-G5-specific_down_only_top_500-EGR2_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21052
BRD-K15997423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33323
DE-48-HZ49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206493
Carcinoma, Hepatocellular_Hepatic Tissue_GSE4612	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.7991
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81501
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26718
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00923
MAX	ENCODE Transcription Factor Targets	1.0	null
Platelet count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	7.30458
ketotifen-5842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11682
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fatty acid derivative biosynthetic process	GO Biological Process Annotations 2015	1.0	null
OPM2	CCLE Cell Line Gene Expression Profiles	1.0	1.42897
HS852T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38965
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971891
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563357
ventral paracommissural tectal nucleus, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12888
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00431
Hypertrophy	CTD Gene-Disease Associations	1.0	1.23074
fatty acid derivative metabolic process	GO Biological Process Annotations 2015	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.92998
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LMO2	ChEA Transcription Factor Targets	1.0	null
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.888892
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34957967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04434
GTEX-OOBK-0526-SM-2HMJJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965024
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866881
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219095
Perturb_5143_KO_Ring1B_ERP008873	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.43159
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19356
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
solasodine-6025	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87456
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.48359
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
EKVX	BioGPS Cell Line Gene Expression Profiles	1.0	1.60453
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
tanespimycin-1650	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00808
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02046
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06073
JB-23-ZE86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.452873
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869925
dexamethasone-2242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCH 530348	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.48
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512082
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IE-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75648723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83195
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.79633
BRD-K11566857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16008
EEF1AKMT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83549
3-acetamidocoumarin-2941	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CREB3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12641
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1106
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IS-A3K7-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K24004917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97275
MAFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20262
primary motor cortex (area M1, area 4)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861872
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72749
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57402
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24294
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.33328
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943896
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964965
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52435
etilefrine-4590	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913131
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ranitidine-1404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K06219419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06709
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDT8-0011-R5A-SM-32PKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84609
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7416
unsaturated fatty acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
7456_RPL28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532409
brain	HPA Tissue Gene Expression Profiles	-1.0	-1.07541
BRD-K55135464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30937
BRD-K79322550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15043
idoxuridine-1480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in posteroventral (inferior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06446
SOX9-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54864
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.859975
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.916219
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04443
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferior frontal gyrus, triangular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.842133
hecogenin-5818	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE5370	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.09779
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67256
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
tanespimycin-5222	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.136733
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.32315
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838416
BRD-K14763154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57338
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.18943
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.18554
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28453
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.237
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	1.39722
GSE223008_11_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FTCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71641
T-00127_HEV1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4736	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ventropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12108
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2439
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266739
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.866532
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cataract	MGI Mouse Phenotype Associations 2023	1.0	null
procaine-1838	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ceftazidime-1721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
peptidase activity, acting on l-amino acid peptides	GO Molecular Function Annotations 2015	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPKOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03336
BRD-K86951121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32672
MZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987281
GTEX-VJYA-0126-SM-4KL1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15878
betamethasone-6728	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
not applicable_Hypothermia_GSE54229_131_mouse_Embryonic fibroblas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
brain	GTEx Tissue Gene Expression Profiles	-1.0	-1.41533
BRD-K59093791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08957
TPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40951
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67256
latamoxef-3028	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS19BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76854
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ES-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAGOHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26018
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
3654_HBS1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527295
ABI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48656
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4116
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6966
COLO-829	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6089
Osteoarthritis_Chondrocyte_GSE16464	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.84852
RA-42-CM42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352788
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00447
BRD-K58977196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36015
CAL-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42998
suramin sodium-7529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03312
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05376
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JE-22-JR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242487
Nucleus of the lateral olfactory tract, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8369
BRD-K48092898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21197
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.843839
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bipolar Disorder	dbGAP Gene-Trait Associations	1.0	0.323533
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63493628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63179
oxyphenbutazone-3582	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r7 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05131
PMC11519602-41418_2024_1333_MOESM3_ESM.pdf-49-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
POLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19987
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
glimepiride-4973	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2665
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
carbachol-6742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8189
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08194
BRD-K54036439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07252
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A4-Fuk	GDSC Cell Line Gene Expression Profiles	1.0	1.44704
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12645
GSE229231_0_v_1_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.71427
Venous hemangioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.704
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.716187
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CYP2D6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38298
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
valproic acid-6199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VMRC-RCZ	GDSC Cell Line Gene Expression Profiles	1.0	1.87354
levothyroxine sodium-4069	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
domperidone-5701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of VPrP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09013
GSE179031_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
HTK	CCLE Cell Line Gene CNV Profiles	1.0	1.71754
Lung squamous cell carcinoma_LUSC_TCGA-22-5491-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.69968
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892185
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20785
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41542
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Avagacestat_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138416
PMC10204296-13578_2023_1034_MOESM16_ESM.xlsx-Black-ZNF671_ZNF671	Rummagene Transcription Factor Associations 2026	1.0	null
SARS-BatSRBD_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.27194
TCS-OX2-29	DeepCoverMOA Drug Mechanisms of Action	1.0	0.59
15172037-Table1	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polymorph layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1179
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955705
Parabrachial nucleus, lateral division, central lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05369
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10069
GSE70883,GSE71179_0_v_1_pbx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_adipose_tissue_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04391
Silicosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
SETDB1-19884255-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.128266
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14714
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nucleus of Darkschewitsch, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26401
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1784
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
alternative	GeneRIF Biological Term Annotations	1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14497
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05068
carcinine-4225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH1105	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63733
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21428
SLC27A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02024
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12343
GTEX-U4B1-0526-SM-4DXTK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21277
CRCGN011_HEPG2_24H:H12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7591
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38382
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56517
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36289
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02357
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.981844
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613004
HDAC2	ENCODE Transcription Factor Targets	1.0	null
intermediate stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12836
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CDHR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02044
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832453
ofloxacin-2302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE189336_1_v_0_nitric oxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BIRC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08755
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.933953
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4506	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75874
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952988
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.903289
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54639
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.862612
WDR33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06271
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.949907
metampicillin-2123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834288
BRD-K43603649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35061
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95472
Sarcoma_SARC_TCGA-QQ-A5VD-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12486367-Supplementary_Data2.pdf-157-RORC_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCCSTCK140	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34219
HCoV-EMC2012_3Hour_23631916_GSE45042	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.11456
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93024
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.58752
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235682_3_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05153
SMAD3-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02099
NAA30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39218
periventricular stratum of r7Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05131
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
CP-863187-7553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01785
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
general	GeneRIF Biological Term Annotations	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89445
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4579349-supp_29.18.1915_Table_S9.xlsx-DOWN_SP1_upperQ-Unnamed_0_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277266
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.58067
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.9259
BRD-K96250732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01972
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47841
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2087
KOPN8	CCLE Cell Line Gene Expression Profiles	1.0	2.05913
BRD-K73114074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04075
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.984217
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gelsemine-2817	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40929
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HA-22-CY42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230274
SF539	CCLE Cell Line Gene CNV Profiles	1.0	1.69179
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926394
CIAO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92886
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_5054_KO_Adnp_SRP104194	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.32869
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46175
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6102
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.983638
BALL-1	GDSC Cell Line Gene Expression Profiles	1.0	1.76478
ZNF384	ENCODE Transcription Factor Targets	1.0	null
GTEX-UJHI-0008-SM-4IHL1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950705
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930974
BRD-K43479153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01132
GSE195582_0_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35802
thalidomide-7288	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.907632
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00643
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08281
BRD-K82910696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1917
BRD-K52876244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64576
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
isoetharine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45867
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.39434
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46999
CRCGN016_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35516
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hypothalamus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.970654
KDM4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26885
valproic acid-1163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pepstatin-1328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140567
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3174
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K71040831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07927
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20728
ARPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15534
TCOF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05393
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62372121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77624
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49161
TCF12	ENCODE Transcription Factor Targets	1.0	null
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40393
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.25179
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1268
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
sulfadimidine-3940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.054
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11054
GSE218580_1_v_2_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04786080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30249
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826926
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.868131
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.52119
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
BRD-K32170456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05077
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
niridazole-5682	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10343715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56266
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25568
Perturb_5221_KO_Zfp57_SRP173610	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.79602
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ceftazidime-5054	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13918
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.957125
GSE207301,GSE207303_0_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0654
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34513
NFE2L2_01_60	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59233
Perturb_15707_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.93258
MPV17L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2243
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84443
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04134
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
small molecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304338
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.76754
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IRF8-22096565-GC-B-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAFK_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
AKT1_Activation - 6 week induction_GDS2308_718_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888575
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bucladesine-591	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02777
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99728124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06964
Perturb_12906_KO_IKZF1_SRP139731	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
mRNA_RAD21_21589869	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MH-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rivastigmine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
hsa-miR-4326	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Turofexorate	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.509941
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-K47511177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78489
intermediate stratum of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60858
GTEX-QDVN-1226-SM-48TZ5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00555
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58373
yohimbine-2755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH660	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48138
SYK_DEPLETION_GDS3609_36_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K98941192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16819
IFRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58592
PC-14	GDSC Cell Line Gene Expression Profiles	1.0	1.75194
Perturb_5847_KD_Zfp30_ERP109794	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30571
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990115
CB-87-GT98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307801
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.82318
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.63312
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04382
SNU520	CCLE Cell Line Gene Expression Profiles	1.0	1.81226
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989805
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07202
acetylsalicylic acid-4428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Peripheral motor neuropathy_Sciatic Nerve_GSE1947	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.52297
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860658
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.845487
LY-294002-6198	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE236072,GSE236075_2_v_0_ccr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZN-0126-SM-4DXUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15582
zimeldine-4609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14162
BRD-K61660466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04002
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
L-1236	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K51535480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04145
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34159
BRD-K56776985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11665
MOTN1	CCLE Cell Line Gene Expression Profiles	1.0	1.79976
BRD-K07826724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17919
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43518
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11569
hydroxyachillin-4213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE148200_4_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77945
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D7_W_B29__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11295
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86065
BRD-K85474153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16995
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02668
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05743
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.21175
ChIP_RCOR3_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23502
RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0552
Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53382
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0452
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06664
KIF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68266
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37042
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
RAGE_knockout_267_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.57039
etilefrine-4415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26181
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE128099,GSE128159_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6791377-oncotarget-10-5768-s002.xlsx-Sheet1-Supplementary_Table_1_The_top_150_DEGs_downregulated_for_the_combined_dataset_of_MYC_silenced_versus_non_silenced_AGP01_cells_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.23398
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28917
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bipolar disorder	GWAS Catalog SNP-Phenotype Associations	1.0	0.057619
KDM5A	ENCODE Transcription Factor Targets	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9253
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3172
budesonide-6330	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
aminopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39989
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.91981
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76637
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6696
ASPC1	CCLE Cell Line Gene Expression Profiles	1.0	2.19315
NCIH196	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72461
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38591
BRD-K85943445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06346
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7448
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.80221
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K73706189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21251
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NSC 87877	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
dl-alpha tocopherol-6616	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08281
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
capsaicin-3372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
retrorsine-2129	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10481024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13193
AG-013608-5909	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K19492738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34743
metitepine-3231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
proxymetacaine-3113	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838934
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52389
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62033
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264936
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67337
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
11051_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.603409
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54905
15906272-Table1	GeneSigDB Published Gene Signatures	1.0	null
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.925035
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	1.0	null
LCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78107
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3202
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.58482
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
magnocellular diagonal band nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07025
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
geldanamycin-864	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01337
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
consistent	GeneRIF Biological Term Annotations	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19509
CEBPD_01_74	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60365
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.827905
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20563
BRD-K62698674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12541
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12108
SIN3A	ENCODE Transcription Factor Targets	1.0	null
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
NUBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81381
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06921
BRD-K23481525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93693
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829966
BRD-K04883778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02103
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81026
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05923
CHAGOK1	CCLE Cell Line Gene CNV Profiles	1.0	1.37819
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-32-DP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25172
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3077
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31202
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6082
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58289
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10508
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44929
Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957312
CRCGN008_HEPG2_24H:C11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47725
Necrosis	CTD Gene-Disease Associations	1.0	1.29595
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33884
fusiform gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.903612
aminocaproic acid-6501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23703
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB-88-VW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212362
methanthelinium bromide-6254	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.937412
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.22685
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HC-01-FD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222911
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63087
Brain Lower Grade Glioma_LGG_TCGA-HT-A74O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01705
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.74015
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27759
A549_Alendronate sodium trihydrate_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125595
dioxybenzone-5699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51956957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02424
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14479
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5333-01A-01R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTV-1	GDSC Cell Line Gene Expression Profiles	1.0	1.494
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4306	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BACH1	ENCODE Transcription Factor Targets	1.0	null
OBF-1_NULL MUTATION_GDS3473_571_mouse_Bone marrow pre-BII cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Inferior colliculus, dorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03125
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	1.0	null
DB-34-QA60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329084
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
moracizine-6000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxybutynin-6770	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513833
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13439
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.50376
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8698
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460906
ELK3-25401928-HUVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JJN-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27806
clebopride-6311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
spectinomycin-4187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25637
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51096
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04773
BRD-K40103182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80827
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML1-OVERLAP_GENES_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64158
BRD-K41189799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35077
demecarium bromide-1781	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36866
CRCGN017_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1915
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35098
BRD-K34117117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13997
BRD-K67661742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08781
SHP-77	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51017
17676974-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6347712-pnas.1812449116.sd05.xlsx-iPSC_IRF7_48h_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4979_KO_Kmt2d_SRP107208	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.71344
NCIH196	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72156
clofazimine-3239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-148b	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.938968
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974958
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59219
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05709
A549_AICAR_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143542
dorsal part of m1A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19053
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88195
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09726
BRD-K22606370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03792
lateral group of nuclei, right, ventral division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.842838
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28256
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08281
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
oxolamine-6624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdalohippocampal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25814
Telmisartan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1826
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04158
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.847948
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48683
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29707
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4459	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RABGGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4711
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829966
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0147
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-18-XC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241927
Lung adenocarcinoma_LUAD_TCGA-55-7725-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.91376
Mean spheric corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.6301
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43437
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NCI-H226	GDSC Cell Line Gene Expression Profiles	-1.0	-2.28886
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37865
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_8758_KO_SETDB1_SRP141213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.10249
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.18554
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06176
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36289
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22641
clenbuterol-5266	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H446	GDSC Cell Line Gene Expression Profiles	-1.0	-2.85543
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_1455_KO_Cd14_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.5302
BRD-K58643762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05313
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SARS-CoV_12Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.99411
naproxen-1869	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
kawain-4693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM2B-26808549-CHIP-SEQ-DND41-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871756
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1107
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11535
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.831834
GTEX-X4XY-1026-SM-46MVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0292
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27049
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23739
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cortical amygdalar area, anterior part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70425
Perturb_17618_KO_TIP60_SRP386872	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.9816
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99426
BRD-K12607407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4751
MYB-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K19020285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20359
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
khellin-1504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K8-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1599	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95944
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.08727
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 3 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43924
nitrofural-2459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600455
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-0526-SM-48U2A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898031
fluorocurarine-5741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53016
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64569
KDM4A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922132
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.55924
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27212
PCI-34051	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.48
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38183
triamcinolone-5835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
alverine-6345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ovary	HPA Tissue Gene Expression Profiles	-1.0	-1.00479
BRD-K69423881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08968
GSE154940_1_v_0_nbdy_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
MCF7_Sodium Phenylbutyrate_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133373
BRD-K08607520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46846
HELZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34917
protein metabolic process	GO Biological Process Annotations 2025	1.0	null
Bipolar Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K19662956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6088
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEx Brain 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	10.6713
CAPAN-1	GDSC Cell Line Gene Expression Profiles	1.0	1.56296
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Superior colliculus, motor related, intermediate gray layer, sublayer c	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24034
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-1226-SM-48TCO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831472
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
harmaline-2149	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LD-14-PB06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271471
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
atropine oxide-4476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MGST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09321
methocarbamol-2274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K55105453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12993
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
carbinoxamine-6786	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.849079
GTEX-S4Z8-0226-SM-4AD5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04563
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.584325
tissue	GeneRIF Biological Term Annotations	1.0	null
EPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32247
BRD-K51185182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04031
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842535
GSE225218_9_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r8 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38772
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75506133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05792
desoxycortone-5357	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16124
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53446
GCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01919
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.700048
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.059
4946_MED23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.662492
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5155877-6549	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241121
alvespimycin-1213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RD	CCLE Cell Line Gene CNV Profiles	1.0	2.06919
PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5	Rummagene Transcription Factor Associations 2026	1.0	null
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20395
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.626
dorsal juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60066
ticlopidine-1895	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYCBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34873
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35664
Mean corpuscular hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.5301
Perturb_11703_KD_MIR31HG_SRP051359	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.043
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69363
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.502578
GTEX-NPJ8-0326-SM-2D7VV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08381
SAP30	ENCODE Transcription Factor Targets	1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54822
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868883
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central layers of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79813
BRD-K74040368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35397
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51304
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131377_4_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908418
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_10857_KO_Shp_SRP220815	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.08775
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28781
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2087
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4655
BRD-K76960970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21301
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11627
colchicine-5675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20897
H4K20me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73953
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45511
BRD-K74656131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45395
EC-98-KI28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268787
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844841
BRD-K94858557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12162
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31755
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013303
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824918
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-A4SS-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51102
bergenin-5870	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.18554
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08494
heptaminol-7313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
housekeeping	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-0126-SM-4LVM9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29318
GTEX-POMQ-0126-SM-48TD6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04953
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613733
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.1119
pro-B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03111
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.926123
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-1.00504
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
IARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73886
halofantrine-3130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456463
GABPA	ENCODE Transcription Factor Targets	1.0	null
ubiquitous	GeneRIF Biological Term Annotations	1.0	null
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247451
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM86B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02812
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endometrium_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14612
BRD-K76351135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05726
TAL1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE49929,GSE49931_1_v_0_irf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-5897-01A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30023
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.513592
PHF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25458
Tongue	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.963352
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979487
mefenamic acid-1863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nafcillin-3983	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pipenzolate bromide-6821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IRF8-22096565-GC-B-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Platelet distribution width	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.70969
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.11639
IKBKE_knockdown_97_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.74619
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17028
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60904
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
flutamide-2358	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0535
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08457
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854144
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.11842
BRD-K74598339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20987
dipivefrine-2744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60732
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.590759
BRD-K40016301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32773
TAL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K52973286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22471
Reticulocyte fraction of red cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.30969
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272282
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09151
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30697
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.880079
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-24	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_6_MRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65821
CTCF-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25385
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59459
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BC-1	GDSC Cell Line Gene Expression Profiles	1.0	1.80627
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46301
BRD-K64353470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24947
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8264
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55146
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08799
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868307
BRD-K30563122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12135
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Gly-His-Lys-6575	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K65152352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00461
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
aminopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601227
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monocarboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477831
BRD-K68083867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65441
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1639
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961676
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88782
depression	GWASdb SNP-Phenotype Associations	1.0	0.40409
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37482
ZFP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45019
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64245731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11688
GJD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26966
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
Lung adenocarcinoma_LUAD_TCGA-55-8619-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7274
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
PRR12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39302
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hexetidine-3318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QLQW-0126-SM-447BK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29867
Perturb_15715_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.59928
BRD-K26694226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43011
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-1.07543
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_5244_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP275780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.42564
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8005
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2019
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44304623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48023
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29281
PNU-0230031-3632	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63304
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900392
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63337
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NUMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53373
RAB3A_Mutation - D77G point mutation_GDS2483_698_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
temozolomide_homo sapiens_gpl10558_gse43452	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955705
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.64492
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BV173	CCLE Cell Line Gene Expression Profiles	1.0	1.39657
EOMES-20176728-TSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.88827
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311976
TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_15710_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.92946
AA-58-FJ71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209507
medial portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836906
EGR1	ENCODE Transcription Factor Targets	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969911
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB(TU)1-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K68333644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21943
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36158
BRD-K96449536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45645
pheneticillin-6105	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52436508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34076
hymecromone-5684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hypothalamic amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12562
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.98354
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210667_1_v_0_rfx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24328
Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218304
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01927
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Superior colliculus, motor related, intermediate gray layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03216
harpagoside-6636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994769
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.6425
SHP77	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68694
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OGFOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7119
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.988573
dilazep-7364	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mefloquine-2210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45897
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95288
CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
clozapine-1654	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47T-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35336753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48621
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08816
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.862847
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.983536
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2963_KD_Nap1l2_SRP304879	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.13717
3329_GDF15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.576939
PRDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15335
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53614
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829966
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2189
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31742
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
2q37 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
SUZ12	ChEA Transcription Factor Targets	1.0	null
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05493
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874244
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.876088
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05541
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250377
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41292
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24523
BRD-K49184477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42751
dexamethasone-5797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
flucloxacillin-6507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26803
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD2-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
polymorph layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03212
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31575
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Entacapone_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01546
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69217
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18083
Lung squamous cell carcinoma_LUSC_TCGA-56-5898-01A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17395396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11658
U87	BioGPS Cell Line Gene Expression Profiles	1.0	0.847351
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87524
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00958
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22812176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05477
Perturb_13290_KO_Trp53/Cry1/Cry2_SRP149358	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5140_KO_Rn7sk_ERP002405	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.13521
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71716722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52157
Rosiglitazone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mafenide-2287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
zimeldine-5670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K73577714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16522
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277589
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SHSY5Y	CCLE Cell Line Gene Expression Profiles	-1.0	-2.53938
dexamethasone_mus musculus_gpl6105_gse44208	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04965
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43863
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38369
BRD-K58876832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92161
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.79442
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67979704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18628
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18324
Perturb_11469_KD_HRP2_SRP305641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.75995
HDQ-P1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hypertrophy, Left Ventricular_Myocardial tissue_GSE2459	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.41952
BRD-K38706080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07763
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430259
CHERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.34711
biological_process	GO Biological Process Annotations 2015	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6259
superficial stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23052
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05856
haloperidol-5563	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55668
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Olfactory tubercle	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12292
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01337
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rescinnamine-2130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.899497
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.46323
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23209
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.911695
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5396
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04285
15(S)-15-methylprostaglandin E2-7526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.893275
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCTN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.999
GTEX-UPK5-1626-SM-4JBHI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30817
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06310280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13596
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59100858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19083
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10052
perphenazine-5698	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15981
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.33701
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE208141,GSE208142_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4492
BRD-K93040255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11989
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834287
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus of the stria medullaris (prethalamic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63781
BRD-K17441474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51745
BRD-K69569958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44284
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2849
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Autoimmune disease of gastrointestinal tract	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21686
0317956-0000-3855	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95323755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27945
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96922
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09863466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45518
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.031905
AFMID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56256
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.41632
HCC1937	CCLE Cell Line Gene CNV Profiles	-1.0	-2.47158
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28654
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0413
USP6NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30964
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9291
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0712
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9044
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70353
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SOX11-22085726-ESNS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.18034
PCMTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51827
SK-LMS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Superior colliculus, motor related, intermediate gray layer, sublayer a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95886
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
meclofenamic acid-2128	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41498330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24602
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.64113
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712365
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12959846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2504
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52947
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
AsPC-1	GDSC Cell Line Gene Expression Profiles	1.0	1.59535
BRD-K03916755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2275
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.14715
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14583
GSE95685_2_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484256
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.997743
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.65935
IA-LM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K86964464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06347
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Superior colliculus, motor related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01328
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36536
methylergometrine-5303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22749
u698	HPA Cell Line Gene Expression Profiles	-1.0	-0.955291
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76587
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12768
GTEX-XQ8I-1626-SM-4BOOI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86115
Hypertension	HuGE Navigator Gene-Phenotype Associations	1.0	null
harpagoside-2935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Red Blood Cell Count Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225095
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.6387
TFAP2C	ChEA Transcription Factor Targets	1.0	null
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946502
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88472
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gdm1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.207
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.715
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31111
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41735
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4799
Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39543844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14719
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.463052
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09328
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
medial pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.28467
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05965
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15651
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	1.0	null
methylprednisolone-3183	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intermediate white layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10091
homatropine-5058	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.92236
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.608231
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991581
BRD-K49461735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03077
pronetalol-3984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K23467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65806
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8233
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
18497862-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mood disorder	GWASdb SNP-Disease Associations	1.0	0.364717
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60267
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77108448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62114
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05505
Perturb_17479_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
OAW-28	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02142
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63431
terazosin-5831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10748141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25784
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59434830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00381
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600527
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.25659
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832453
BRD-A47428621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20583
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW948	CCLE Cell Line Gene CNV Profiles	1.0	1.3985
GABBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50826
chlorpromazine-4441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ6-0126-SM-48TC6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827582
NCIH2141	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58584
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RA-49-ZB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204648
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5676-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14162
CTCF	ChEA Transcription Factor Targets	1.0	null
STAT4-19710469-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239592
NUP85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23425
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.72856
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15343
HPAF-II	GDSC Cell Line Gene Expression Profiles	1.0	1.49981
N-acetylmuramic acid-1326	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05251963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01624
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49824
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
outer SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20861
Red blood cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.32218
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12215
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42029
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.87916
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.935833
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29003
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36857
High light scatter reticulocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.32218
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475036
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.835048
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8221
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4167-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60498
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221302
M059J	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90185
hESC_Derived_CD56+_Ectoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.06212
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28803
(+)-isoprenaline-3384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984459
BRD-K62102480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29832
BRD-K75168124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2331
BRD-K16733272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5854
GTEX-PX3G-0926-SM-48U12	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92215
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89653
LTBR_INHIBITION - 35 Day_GDS2005_732_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
thiamphenicol-1867	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PFKL_OE_GDS1079_201_mouse_myoblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LN340	CCLE Cell Line Gene CNV Profiles	1.0	1.6302
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55489373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08024
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LY-01A-31R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.918832
nifedipine-1856	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08494
OVCAR4	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.01958
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71566
687_ATP6V1H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513702
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.18554
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97693
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.18554
Perturb_4962_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.40677
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37258
Perturb_12308_KD_CDK12_SRP073459	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.8396
SNRPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68044
BRD-A43575461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20862
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.971398
GTF2B	ENCODE Transcription Factor Targets	1.0	null
gabapentin-5875	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13299
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04545
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-2q37_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.326976
intermediate pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.407
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K41538715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10179
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72342
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.048946
GXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21657
trioxysalen-5736	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85941
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52978
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.27657
RPMI 8226	BioGPS Cell Line Gene Expression Profiles	1.0	0.890026
ticlopidine-4155	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K47254434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08987
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858005
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.894533
Coronary Artery Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
metallopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18721
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
ROCK_INHIBITION_GDS3944_462_mouse_Forebrain astrocytes - 6 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_4981_KO_Kmt2d_SRP107208	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
verapamil-6287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SH-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCSAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75675
icSARA deltaORF6_0Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.82759
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.46614
BRD-K04441230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16223
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Rabies CVS-11_7day-Brain_22116324_GSE30577	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.76257
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4537_OE_TET3_SRP099074	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.86024
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPFIA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66141
fluphenazine-3194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44378
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71422
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mania	GWASdb SNP-Phenotype Associations	1.0	0.882984
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11338
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01619
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33733
PMC12486367-Supplementary_Data2.pdf-238-ATOH8_ATOH8	Rummagene Transcription Factor Associations 2026	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00212
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.889323
KE39	CCLE Cell Line Gene Expression Profiles	1.0	1.54544
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18859
hsa-miR-301a	TargetScan Predicted Conserved microRNA Targets	1.0	0.047969
DYNC1H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14247
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91686
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88820027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03317
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0023
BRD-K67689282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59437
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49101
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0942
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17355
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5205_KO_Ddx6_SRP137727	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.57738
GSE80182_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5902
Perturb_6764_KO|KD_SERPINE2_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.04359
lateral septal nucleus, intermedio-dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02017
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01222
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72651085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1347
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17573
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18013
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26363
hsa-miR-4295	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RSAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2144
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.02062
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36058
8729_TBCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.596973
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.03605
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954163
EZH2	ENCODE Transcription Factor Targets	1.0	null
Septohippocampal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30511
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21111
AASDHPPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5397
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66378
BRD-K99764436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48054
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08832
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53316
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
harmaline-6623	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61224
tranexamic acid-2248	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69432
hsa-miR-4446-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
ifosfamide-5805	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271924
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60085
Perturb_16512_KD_PAX9_SRP300302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980836
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
triprolidine-2376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRL-0526-SM-2I3EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866436
PMC10130768-LSA-2023-01950_TableS5.xlsx-Genes_repressed_in_Primary_PCa-BAZ2A-TAM_repressed_in_BAZ2A_KDM1A_High_primary_PCa_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94145457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27041
GSE111247_14_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.39426
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
clemizole-4695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64751
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501005
Annular pancreas	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9935
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5483-11A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amprolium-1479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_2837_KD_CDK12_SRP073459	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.88621
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-85-VH07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294912
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11497
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Duodenal atresia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
BRD-K14732815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2013
Mean corpuscular hemoglobin concentration	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.8
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
fipexide-5737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
altretamine-5688	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09248
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40685792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08472
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
pallidal islands of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24677
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34869
iobenguane-6002	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.515557
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD2-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59832
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K65773140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2674
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55621
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81954791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04274
GTEX-S3XE-0626-SM-4AD6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13462
GTEX-XAJ8-0126-SM-47JYG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07378
BRD-A99402294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26008
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429568
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.81096
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KOSC-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.82808
TMEM128	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79454
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K42877297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30666
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
boldine-4004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09493
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.424
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402673
BRD-K96491664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3117
SUIT-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864788
Acute Myeloid Leukemia_LAML_TCGA-AB-2866-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
iproniazid-2125	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pyramidal layer of IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26025
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.18113
USP39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5176
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE215086_8_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06682
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_GSK-LSD1 2HCl_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129537
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.934288
trimipramine-4163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Armadillo-type fold	InterPro Predicted Protein Domain Annotations	1.0	null
frontal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.952723
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.46753
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68008192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30835
tectal gray formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92199
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
D-392MG	GDSC Cell Line Gene Expression Profiles	-1.0	-2.26118
BRD-K81982648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06956
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79569
PU.1-20176806-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06352
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00964
prazosin-942	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.24304
A-VN-1203-2004(H5N1)_Day2-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.15641
PCDHB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23506
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.28623
lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE207914_1_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XMK1-0126-SM-4B65F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11272
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36252
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45067
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37366
BRD-K75672292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10084
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929859
BRD-K29549246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26354
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02718
sitosterol-4154	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
valproic acid-5211	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13285_KO_Mettl14_SRP182641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.95371
GTEX-U4B1-1726-SM-3DB9F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829462
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC2A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10614
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.652647
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66913
vinburnine-6802	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-V955-1726-SM-4JBHF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896381
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201883
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CPOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527937
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86185
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0112
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
heptaminol-1703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01043
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20478
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1279
harpagoside-7355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.91079
PMC8799469-41591_2021_1576_MOESM8_ESM.xlsx-Fig2e_-_E2F4_808g-SCENIC-predicted_targetome_for_E2F4_808g_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.56565
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A72Z-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22905
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.862821
CRCGN015_MCF10A_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23105
Plateletcrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.5
parastrial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23036
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35656
aconitine-2776	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927468
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1591
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.5617
Perturb_4603_KO_Mst_SRP246200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.33123
CTCFL	ENCODE Transcription Factor Targets	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.46185
BRD-K11835238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09932
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02778
GSE205163,GSE205164_1_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.858441
GTEX-QVUS-0626-SM-447CC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884375
Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372523
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833087
FOXO1_KD_GDS2720_477_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1784
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950139
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04498
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12517
etiocholanolone-2204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A12830281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33923
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30198
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19213
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
telenzepine-2388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dimethadione-3029	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4389-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.592394
GSE184884_6_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Arthritis, Rheumatoid	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hmgn1_KO_GDS5010_406_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828472
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32267
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K41762421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55814
BRD-K37304120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2132
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835058
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.709052
GTEX-UJHI-0126-SM-4IHLP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926647
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05923
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4775_KO|KD_Mll2|Cxxc1_SRP189864	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.78806
Peptidase M1, membrane alanine aminopeptidase, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.66389
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2948
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05923
BRD-K11474067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51463
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04387
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830132
GSE110178_5_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.28857
Perturb_4976_KO_Kmt2d_SRP107208	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.80875
FAM222B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22483
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67594
AD-09-MD49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217662
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25255
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2689
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP100_01_82	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59934
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.81318
oleandomycin-5676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0907
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
folic acid-7201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OIZH-0926-SM-48TBR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15666
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07424
PI4KB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36571
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86070914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33551
BRD-K54370483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42201
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829865
trapidil-6515	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tanespimycin-5578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
meclocycline-4982	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K03713632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00768
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235771
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
7427_RPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553215
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IDH3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1635
nucleus of the lateral olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72593
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48466
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33483
L-methionine sulfoximine-4151	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47321
mRNA processing(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GTEX-N7MT-0326-SM-48TDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829195
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.61655
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.902774
NUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	1.39936
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.03794
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88563
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.877403
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25723
gliquidone-6004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NSC 23766	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26368
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840777
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219431
sulfanilamide-3449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38915
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.25844
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921579
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24246
skmel30	HPA Cell Line Gene Expression Profiles	1.0	1.1512
5501_NCKIPSD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551715
GLC82	CCLE Cell Line Gene CNV Profiles	-1.0	-2.04372
iopamidol-5832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
suprofen-3343	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A545-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55363
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09988
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R3-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50414
procyclidine-4817	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rtpcr	GeneRIF Biological Term Annotations	1.0	null
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.02334
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYD88_Deficiency_GDS2650_652_mouse_LUNG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50619
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11818
GSE228181_0_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
submammillothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01928
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.86
Prestwick-920-3118	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18557
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
P31FUJ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57744
corticoid layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45825
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05923
spleen	HPA Tissue Gene Expression Profiles	1.0	0.972263
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79597
Hypertension_Adrenal gland_GSE1674	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.24732
denatonium benzoate-3123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04593
hsa-miR-3689c	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
GSE87412,GSE92423_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
U-87-MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54099
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86209
BRD-K05261060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04974
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23702
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amrinone-6826	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nomifensine-2224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K48999921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80253
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78103
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.805246
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15690866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34158
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.8535
GM2313	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.44891
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59028
ID3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41573
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.956883
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
peripheral nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06015
pizotifen-3134	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13163
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.887713
PMC11666716-41698_2024_782_MOESM1_ESM.pdf-2-PRDM10_PRDM10	Rummagene Transcription Factor Associations 2026	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22249
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCA1_Knock-in_GDS3544_562_mouse_Cerebellum - 12 Weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
mephenesin-2304	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bone inflammation disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.054
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15455
RF-48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54547
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLTM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43121
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SNRNP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07268
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
xylazine-2132	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22118
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2911
promethazine-3100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42837
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.612862
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-THP-1_MLL-AF9_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.97628
BRD-K77403813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01039
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
haloperidol-4678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08302
hsa-miR-4706	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9004
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-2426-SM-2TC5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11826
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8825
sodium-phenylacetate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34262
AA-58-FJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293957
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.03939
BRD-K63102090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01004
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.90751
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6557
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAMKK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47596
EFO21	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77271
HuP-T4	GDSC Cell Line Gene Expression Profiles	1.0	1.79997
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35802
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44797
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41796
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17233
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
splicing	GeneRIF Biological Term Annotations	1.0	null
MET_knockout_260_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.98447
GTEX-OHPK-0526-SM-2HMJB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837111
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SBC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.30117
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00657
Perturb_3787_KD_GLI1_SRP042158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	1.166
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20511
Perturb_7542_KD_CTCF_SRP275505	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC827GR5	CCLE Cell Line Gene Expression Profiles	1.0	1.52346
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00747
lymphnode_5b	HPA Tissue Sample Gene Expression Profiles	1.0	2.06759
GTEX-XYKS-0526-SM-4BRW2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959743
GTEX-QDVN-0526-SM-48TZ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03479
BRD-K25444802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01058
YF-00-IN39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492668
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.223
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RUSQ-0126-SM-47JWV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1801
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CT-01A-31R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48235506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26885
BRD-K93186184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19852
Fluticasone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MDAMB157	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46249
BRD-K98805845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29292
LYL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K39649774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01255
dorzolamide-3565	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMPDL3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88875
BRD-K84517695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37078
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAGE_knockout_268_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.7916
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42508
GTEX-UPK5-2026-SM-4JBIM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998113
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9148_KD_KIAA0853_SRP307037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.66889
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20689
isoxsuprine-1485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxetacaine-1484	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K29636267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24036
UD-07-US73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308323
Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-42-IC00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27191
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.637
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-661	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Hematocrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
NCIH838	CCLE Cell Line Gene Expression Profiles	-1.0	-2.1688
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328113
ECD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5192
intermediate stratum of PThE	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63919
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.50853
BRD-K12107215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41037
BRD-K28039328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23697
dorsal part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60858
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06169
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296678
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94009
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.922008
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BTK_KO_GDS1346_302_mouse_splenic B cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.890628
mantle zone of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17133
ctcf_18614575_oocyte_lof_mouse_gpl1261_gse11664	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.87195
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.3628
RH30	CCLE Cell Line Gene CNV Profiles	1.0	1.94359
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40498
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52317
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41197
spleen_3d	HPA Tissue Sample Gene Expression Profiles	1.0	1.02061
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AE-04-SN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535203
trichostatin A-2474	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200438
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5413
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
idazoxan-6747	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
outer SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868078
metalloaminopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
PWWP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09544
Perturb_5199_KD_Cnot1_SRP128098	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.56183
GTEX-Q2AH-1126-SM-48TZM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972225
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05878
ESRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63095
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IRF8	ChEA Transcription Factor Targets	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342079
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921333
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46135
NCIH661	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8521
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964965
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.70982
TCCPAN2	CCLE Cell Line Gene Expression Profiles	1.0	2.05125
Hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
BRD-K77480803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07195
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.036957
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.94375
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7756
TCF3	ENCODE Transcription Factor Targets	1.0	null
AA-49-BD04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276262
USF2	ENCODE Transcription Factor Targets	1.0	null
icosanoid metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A84867566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31965
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
bupropion-5782	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.992437
BRD-K56261053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43989
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82609503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38285
carbenoxolone-4093	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13052
TTC39C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65964
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.14787
COV318	CCLE Cell Line Gene CNV Profiles	1.0	1.36613
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854382
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871245
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukotriene biosynthetic process	GO Biological Process Annotations 2015	1.0	null
TOSEDOSTAT	DGIdb Drug Targets 2026	1.0	2.78589
IGR39	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05418
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UMUC1	CCLE Cell Line Gene Expression Profiles	1.0	1.53846
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF830	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07425
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1-30970003-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
CDKN1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49752
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20893
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51815
2536_EIF2B2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553724
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25494
MOLP2	CCLE Cell Line Gene Expression Profiles	1.0	2.25856
astemizole-2211	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6538380-elife-42374-supp3.xlsx-human-sp-ENSG00000007866_TEAD3	Rummagene Transcription Factor Associations 2026	1.0	null
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.899488
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48534
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19778
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.97888
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85081
LU-134-A	GDSC Cell Line Gene Expression Profiles	-1.0	-1.7997
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-BatSRBD_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.41649
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43325
valproic acid-1634	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
methotrexate_homo sapiens_gpl571_gse9412	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XGQ4-0126-SM-4AT4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2043
MANBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74184
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66913
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANKRD33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63027
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EK-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90808566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15348
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827851
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503762
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913214
PDGFRA_activemutant_54_GSE17743	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.04947
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34605
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
induseum griseum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26025
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gentamicin-2245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.676834
em2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.795
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331548
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9819
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4094
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.21848
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4974_KO_Kmt2d_SRP107208	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.46381
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.836828
SETDB1-19884255-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.595
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.715925
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aztreonam-5535	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pralidoxime-6443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.20942
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33982
chloropyrazine-3570	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06404
Inflammation	CTD Gene-Disease Associations	1.0	1.49356
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32856496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64907
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.054
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_4005_KD_LMNB1_SRP320092	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.07092
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913584
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1076
8820_TERF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543502
GSE144443_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61851
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207666
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1306
BRD-K32511780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26046
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07017100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07333
minoxidil-1496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35903
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
THAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58538
SOX9-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24795
CALU6	CCLE Cell Line Gene CNV Profiles	1.0	1.67053
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.01473
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.867198
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.93668
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06077
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Polycystic Ovary Syndrome_Adipose tissue_GSE5090	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.52394
Ripasudil	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
examined	GeneRIF Biological Term Annotations	1.0	null
OCI-AML2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05057
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10789
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1467
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
bacampicillin-3273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMBIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12667
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04725
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.38862
A549_Alendronate sodium trihydrate_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00947742
PMC6883319__F9	PFOCR Pathway Figure Associations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12152
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.42166
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247865
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22986
ES8	GDSC Cell Line Gene Expression Profiles	-1.0	-1.66795
MYC-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28831
BRD-K89501960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74115
BRD-K38972344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10888
layer 2 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9166
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12683
CASKIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67861
BRD-K94582731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29655
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.857385
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SR-95639A-3272	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244918
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.963092
CRCGN008_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2576
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38485
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57771
GEMIN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20256
GTEX-T5JW-0126-SM-4DM6K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06921
BRD-A73965025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58116
plexiform layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42013
minaprine-4230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.849895
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503261
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAPAN1	CCLE Cell Line Gene Expression Profiles	1.0	1.63487
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12472
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.814421
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prasterone-3097	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UQCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77618
DHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15074
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SUCS-0626-SM-32PM5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05228
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.90773
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8426-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11913
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16814
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478037
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3Y4-01A-51R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.55941
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17591
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.596733
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32545
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.02585
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15198
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23642
simvastatin-3340	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vanoxerine-5702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.20081
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78971
5194442-6599	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
plicamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31788
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882662
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02984
mantle zone of VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12154
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24894
REST	ENCODE Transcription Factor Targets	1.0	null
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
Biliary tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849762
KLF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55587
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8669_TAF7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523854
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33533
4,4'-Dimethoxybenzil	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE202434,GSE202438_2_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07194
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38119
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47541706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64679
ricinine-6206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42249
CRCGN015_MCF10A.TP53.M_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0842
PMC6883319__F9	PFOCR Pathway Figure Associations 2024	1.0	null
GSE239844_11_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
heliotrine-2180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91839
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.883411
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610769
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25638
Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75413392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1326
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13309514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10579
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86208
BRD-K45289917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21249
BRD-K91895574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77647
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05031
NCIH1618	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05213
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75505
PMC9229595-Table_2.xlsx-LPS_subset_IX-Unnamed_15_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24164
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4947_MED24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517013
disease	GWASdb SNP-Disease Associations	1.0	0.025361
peduncular nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08158
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.899538
mantle zone of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91932
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.20471
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42365
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74148
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.58527
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373539
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19432
DNAJC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13529
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21333
PRKAG3_Mutation (R225Q)_GSE4067_390_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05775
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36095954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77014
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83769
GON4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.76766
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.8465
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27468
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435697
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cefotetan-3997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rpmi8226	HPA Cell Line Gene Expression Profiles	1.0	1.09995
PMC10130768-LSA-2023-01950_TableS5.xlsx-Genes_repressed_in_Primary_PCa-BAZ2A-TAM_repressed_in_BAZ2A_High_primary_PCa_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931224
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39951
PMC4579349-supp_29.18.1915_Table_S9.xlsx-DOWN_MYC_upperQ-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48372
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43977
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10795826-jciinsight-8-170518-s128.xlsx-Fig_5B-Gene_Regulated_by_VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20214
periventricular stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31663
hsa-miR-454	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4075
parvicellular interstitial nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84936
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12701
AM 630	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ8I-1726-SM-4BOQB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17651
PPP2R5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07909
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563572
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12275
NLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51904
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20896
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54691
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21073
GM2493	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.06729
BRD-K79887921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45959
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2806
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.88286
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829031
17660535-TableS4b	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2613_EMC3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.786692
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30124
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06039
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43485
GTEX-RWS6-1026-SM-47JXD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59048
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2
BRD-K32916996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02216
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	0.903
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28814368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80993
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.18651
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01644
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.872031
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-7173-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pimozide-6780	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Montelukast	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
Perturb_15713_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.44934
Perturb_2814_KD_TRIM25_SRP267938	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.46256
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389534
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24381
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.071278
BRD-K67563379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6968
Nucleus of the solitary tract, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05177
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892185
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crohn's disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.997
estriol-3563	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6-bromoindirubin-3'-oxime-6559	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7727-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49123
retromammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17086
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24169
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5934
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76388
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64656
Olodaterol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12528
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103122_0_v_1_riok3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30293
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	1.0	3.10974
hydrocortisone-3284	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DMS153	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53686
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200325
hsa-miR-130b	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
SEC16A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25854
GTEX-SE5C-1026-SM-4BRUG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921562
BRD-K09655230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23414
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.958195
IKZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.268
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3533
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-0226-SM-48U1I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967666
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23430405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18435
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
griseofulvin-3664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21393
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65931
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832835
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11575
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73249
INTS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18338
Perturb_9734_OE_ADAR_SRP401122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10020_ZC3H13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.596678
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18402
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35641
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.389
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12509
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08281
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480991
TUBE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15077
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.984927
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.076
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171845_4_v_3_ccne1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63921431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70433
BRD-K97748753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06127
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
Phosphatidylinositol 3-kinase complex, class IB	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46821
GTEX-WY7C-2726-SM-3NB3P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07914
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.50553
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4423
CRCGN015_MCF10A.WT.HP_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25007
hsa-miR-130a	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00337
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
phenacetin-4111	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-A17831693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76545
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAPK8IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36378
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75403
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30947
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4QS-0926-SM-48TBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19335
BRD-K73463737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1664
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3327
oxybenzone-6309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD4-28847988-BCBL1-HUMAN-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cefadroxil-4080	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.26592
alprostadil-6571	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2834
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16481
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02126
BRD-K63383299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66117
Olfactory tubercle, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10311
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.991156
periventricular stratum of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14281
Superior colliculus, motor related, intermediate gray layer, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09307
SARS-CoV MA15_Day7_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.34913
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81714
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.838863
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.77388
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87311
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
increased vertical activity	MGI Mouse Phenotype Associations 2023	1.0	null
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prestwick-984-4948	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01879
GSE119978,GSE180930_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65863
arthritis, rheumatoid; coronary artery disease; crohn disease; crohn's disease; diabetes mellitus type ii; diabetes mellitus, insulin-dependent; diabetes mellitus, type 1; diabetes mellitus, type 2; hypertension; rheumatoid arthritis	GAD Gene-Disease Associations	1.0	null
CCDC152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33673
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.834084
Lung adenocarcinoma_LUAD_TCGA-MP-A4SW-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.50694
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88584
Cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65577
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836559
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35676
Ulcerative colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
IFT140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04082
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18845
1298_CCDC84_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540441
PMC12699144-CTM2-15-e70552-s001.xlsx-T_CD8_c03_ZNF683-Unnamed_0_ZNF683	Rummagene Transcription Factor Associations 2026	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.836724
BRD-K15779027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45205
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PHETA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76923
BRD-K12531686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53632
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837419
hepg2	HPA Cell Line Gene Expression Profiles	1.0	0.956239
STAT3	ENCODE Transcription Factor Targets	1.0	null
FBXO22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6793
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01687
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7007
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516051
artemisinin-1714	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_3_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
cellular lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20416
pirenzepine-2234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sertaconazole-6128	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fatty acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32704
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99304
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2325
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1179
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
carcinine-1305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU349	CCLE Cell Line Gene Expression Profiles	1.0	1.81355
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.60702
PLEKHA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12145
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.39473
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
MTA3	ENCODE Transcription Factor Targets	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
myosmine-6055	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923105
Perturb_5044_KO_Ssu72_SRP167695	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.47242
pallidal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29053
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.893733
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16198
BRD-K12709183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83412
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RMGI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56397
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5174-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06507315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12511
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31829
MLLT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75645
hsa-miR-4697-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843955
GSE199874_3_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17133
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4289
L-428	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Cerdulatinib_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114372
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91934
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21387
5253409-844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CC-15-MK46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22615
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8510-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
proteolysis	GO Biological Process Annotations 2025	1.0	null
gemfibrozil-2277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.93055
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nordihydroguaiaretic acid-5583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13248
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2027
Nutritional deficiency, NEC_Skeletal Myocyte_GSE1776	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.45233
Alveolar rhabdomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58075863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39639
NFYB	ENCODE Transcription Factor Targets	1.0	null
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65857
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19681
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-NB4-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52319
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53302
DHX37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56519
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A3Y1-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE241847_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39953
Brain Lower Grade Glioma_LGG_TCGA-DU-A76O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41575
etofenamate-3989	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.856015
BRD-K63864310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07568
19294737-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30471
MAFK	ENCODE Transcription Factor Targets	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06959
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19001
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.981526
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
bipolar disorder	GAD Gene-Disease Associations	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.37104
SLC25A36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04335
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64169
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.991739
Lung adenocarcinoma_LUAD_TCGA-80-5608-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26865
trifluoperazine-1224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pirenperone-3316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.34617
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289062
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NYNRIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28319
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13613
KE39	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
FADS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24055
IZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16775
BRD-K64593260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2939
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231799_2_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93508241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3687
Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955837
BRD-K62982533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0737
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0395
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
Isoproterenol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.65
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125928
Chicago Sky Blue 6B-4971	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60045
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2686
dorsolateral IC periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14082
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9747_VPS28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.891669
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A78T-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.294
Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70558130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14737
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824783
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57827
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6278
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62325456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11053
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.992652
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38164
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57929
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.990261
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
isoetarine-2711	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A89237309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54511
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42755
GSE113734_3_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45852
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2597
BRD-K45860594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20316
BRD-K67526257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16701
haloperidol-1669	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A-CA-04-2009(H1N1)MA_Day3_22532695_GSE36328	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.32109
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
naringenin-1342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.90836
GRSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14289
myosmine-4759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
exopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20882
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915174
RCC10RGB	GDSC Cell Line Gene Expression Profiles	1.0	1.5914
clobetasol-4497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5104_KO_Ythdc1/Dux_SRP251747	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.6318
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517439
BRD-K72071403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17403
BRD-K17231179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14333
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144443_0_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144919,GSE145177_1_v_0_dazl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.997692
GFI1B	ChEA Transcription Factor Targets	1.0	null
KMH-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0779
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.893771
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93246
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KP-N-YS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.63062
BRD-K28885073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03991
A375	GDSC Cell Line Gene Expression Profiles	-1.0	-2.03433
BRD-K47748211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0119
mebeverine-1576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09821
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2108	CCLE Cell Line Gene Expression Profiles	-1.0	-2.49139
SHANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10923
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MYOD1	ENCODE Transcription Factor Targets	1.0	null
enlarged lymph nodes	IMPC Knockout Mouse Phenotypes	1.0	null
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
zinc ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K51919278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8348
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BCP1	CCLE Cell Line Gene CNV Profiles	1.0	1.55487
Sarcoma_SARC_TCGA-DX-A3UC-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71505
PMC9490101-mmc3.xlsx-Sheet1-Supplementary_Table_3_Differentially_expressed_genes_in_CASC11_KD_MHCC-97H_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
metalloaminopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
superficial stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81713
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64268886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2953
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663001
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.961733
BRD-K48102350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05339
BRD-K17372597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41066
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Perturb_13273_KO_Spen_SRP198728	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.48994
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
methyldopa-3234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04801
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61945
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519299
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2598
RIGI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11081
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233777
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550531
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89325
Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DLX5_KO_GSE22381_5_mouse_ear (otic vesicle)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
leukotriene metabolic process	GO Biological Process Annotations 2015	1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215955
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
16-phenyltetranorprostaglandin E2-7546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96345
abnormal lymph node morphology	MGI Mouse Phenotype Associations 2023	1.0	null
PPARD	ChEA Transcription Factor Targets	1.0	null
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGC-1alpha_Deficiency_GDS4904_311_mouse_Aged gastrocnemius muscle - 24 months	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3565
GSE192663_1_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.15128
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	1.5636
Lixivaptan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
cataract	IMPC Knockout Mouse Phenotypes	1.0	null
GSE134375_0_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04589
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16238
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337156
CREM	ChEA Transcription Factor Targets	1.0	null
PMC11438719-43032_2024_1653_MOESM4_ESM.xlsx-dNKall6orig-dNK_MAF_1_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
ticlopidine-1475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SNOS-1426-SM-32PLY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905273
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842956
OE19	CCLE Cell Line Gene Expression Profiles	1.0	1.5488
tropine-6147	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ebolavirus(ZEBOV)_7day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.25494
KARPAS-1106P	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0274
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.919567
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18905
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.99568
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64279
iocetamic acid-3361	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ANKRD65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91072
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04251837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48694
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53771
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chenodeoxycholic acid-2402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TRAPPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99229
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04635516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01129
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4456
LY-294002-1664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mepyramine-1568	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23004
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHEK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54996
BRD-K82578220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.71165
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35584
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.75435
A-CA-04-2009(H1N1)_6Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.02329
hsa-miR-4749-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8584-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00934
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65236
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
CEBPB-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
17597811-SuppTable6	GeneSigDB Published Gene Signatures	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868883
Perturb_9149_KD_VIRMA_SRP307037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.38171
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826018
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
Peripheral nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70401
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12689
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504974
BRD-K54903703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02224
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45673
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498596
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824534
BRD-K86467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39983
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.622
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.18554
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.66284
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08182
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 527	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hippocampus (hippocampal formation)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.911284
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72609226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00619
BRD-K72993421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03986
YY1_Deficiency_GDS4856_318_mouse_Soleus skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
torasemide-5057	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10010414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07183
immune	GAD High Level Gene-Disease Associations	1.0	0.293278
Ventilator-associated lung injury_Lung Tissue_GSE2411	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.65227
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.995449
dorsolateral SC part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13383
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GCIY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50621
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43809
Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07536
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923778
FAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39256
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834693
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06851
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.973489
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ac2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-1326-SM-4BRWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923449
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968562
intermediate stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78299
pilocarpine-6741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ergocalciferol-3304	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.051
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829966
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54881917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09197
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352919
GTEX-POMQ-0826-SM-3P61H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87263
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519447
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04262
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.85858
GTEX-OIZH-0526-SM-2HMKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947173
COLO704	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02047
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54647
L-741	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
WA-45-ZD47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27739
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855396
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16916
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34271
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24377650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31476
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
trimetazidine-2876	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K30782795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06025
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
heptaminol-1866	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A678-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
prethalamic eminence	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63919
BRD-K44613656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05844
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3777_KD_GLI1_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K47261271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44797
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
valproic acid-347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-2600-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
isometheptene-5082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K04513994	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65147
CRCGN015_MCF10A_48H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04003
BRD-K81175414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23202
GTEX-T2IS-0526-SM-32QP9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831636
BRD-K61209548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14734
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5328
BRD-K75606012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45677
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67409155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27327
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.999561
RCOR3	ChEA Transcription Factor Targets	1.0	null
A549_Mesna_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157789
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.1102
EOMES	ChEA Transcription Factor Targets	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69885
PMPCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50217
mantle zone of PThE	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63919
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56501
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K57202089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38949
SLC19A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51324
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941427
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15534
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.529878
clorsulon-1735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4T7-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0926-SM-48TDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25546
BRD-K32506050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45652
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67164
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-2861	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CRKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.8785
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21881
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67667
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6851
BRD-K73025852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1712
carboxylic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
USF	MotifMap Predicted Transcription Factor Targets	1.0	null
T84	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75486
all	GeneRIF Biological Term Annotations	1.0	null
DDX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5935
DB-21-FY25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269851
BRD-K74665927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00395
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.957161
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960964
pyridoxine-7171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11247495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00641
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.958091
ZNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14899
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.36059
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06176
Platelet Count Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
ARHGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2661
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13861
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.93873
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
desipramine-6693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68796
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4505-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nortriptyline-2391	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Nucleus of the lateral olfactory tract, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40816
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.823652
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337112
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09897
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66884
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05599
CEBPD	ENCODE Transcription Factor Targets	1.0	null
BRD-K06863452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57057
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.833923
NCIH1876	CCLE Cell Line Gene CNV Profiles	-1.0	-2.41895
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C19orf53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50049
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U937	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05445
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26401
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MTERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03132
dorsal part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01789
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91585756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13199
GSE148200_1_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.863052
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCLC21H	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56784
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15468
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
hsa-miR-759	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316944
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6870-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79597
HDAC6	ENCODE Transcription Factor Targets	1.0	null
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
oxyphenbutazone-4506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K77554584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06472
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35594
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
fulvestrant-6197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.990804
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
oxetacaine-4246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13439
BRD-K44675576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02342
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24931
carbinoxamine-2725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39812
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1192
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.621724
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0052
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.79694
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91417
C32	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43286
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30607
nucleus of the diagonal band, left, vertical division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.939716
BRD-K89514545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25774
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.824454
GTEX-XXEK-0126-SM-4BRVU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12231
PFKFB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62546
8196_SMYD4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.845136
cloperastine-3408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25681
nalbuphine-7177	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923428
POMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43479
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.891556
BRD-K47690679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34422
dactinomycin_mus musculus_gpl6246_gse21233	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14547
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.924245
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25661
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967939
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.113
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.916317
KDM2B-26808549-CHIP-SEQ-SUP-B15-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59089
nortriptyline-6003	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A02501536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34676
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymph node	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K99078335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44384
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PITPNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07627
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64035
FD-62-ZB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37155
Resmetirom	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19956
Lung adenocarcinoma_LUAD_TCGA-78-7149-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJMC-0426-SM-4IHJF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837505
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A54490075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31311
Perturb_7265_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.21557
Prestwick-972-6511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129772_2_v_3_runx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57037
Microspike	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
nucleus of the stria terminalis, medial division, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30785
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.934626
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dextromethorphan-1281	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21894
CRCGN015_MCF10A_48H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14957
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22064
cotinine-5246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMAD2	ChEA Transcription Factor Targets	1.0	null
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.98665
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.973489
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06197
Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6863-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79644
ribavirin-6521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.464737
superficial layers of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.13539
cation binding	GO Molecular Function Annotations 2015	1.0	null
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07156
metalloexopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chlormezanone-4636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16154498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06292
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0581
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24332
BRD-K42776812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22246
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00418
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.84371
inner SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831796
hsa-miR-185	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
suxibuzone-5806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6841
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-12-IW93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35189
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EO-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAP30BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22786
dorsofrontal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57733
BRD-K52833964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23675
PMC10130768-LSA-2023-01950_TableS5.xlsx-Genes_repressed_in_Primary_PCa-BAZ2A-TAM_repressed_in_BAZ2A_TOP2A_High_primary_PCa_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
UBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11925
BRD-A19829191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01844
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4848
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K56441027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22142
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
terguride-6299	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42378
BRD-K35909757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34627
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329776
Inflammatory bowel disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03843
CD-47-YL43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241869
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08674
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dilazep-2294	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
15(S)-15-methylprostaglandin E2-7489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Maraviroc	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.6
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15945
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55O-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57929
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0226-SM-33HB5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839375
Acute Myeloid Leukemia_LAML_TCGA-AB-2835-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4829_KD_Rrp40_SRP150410	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.05105
Prestwick-857-4980	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-DX-A2J1-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16834
icosanoid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Perturb_1197_KO_Klf13_SRP302435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.78448
Fastigial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09504
medial parabrachial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19818
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09237
MCRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74349
GTEX-PW2O-0526-SM-2I3DX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896102
H3K27me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43036
hsa-miR-4314	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92527
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53551
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18362
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
benzylpenicillin-3577	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927145
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Macrophage_Spleen_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.61403
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829703
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4602_KO_Mst_SRP246200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.46116
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58844
SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.869624
MYC	ChEA Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.973222
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHA-00767505E-6550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75708
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31092
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molsidomine-6325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13832
GSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51606
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918737
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47446
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311161
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.311
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10652
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829966
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
increased vertical activity	IMPC Knockout Mouse Phenotypes	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.07863
nifedipine-6006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5742
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20334
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77948
benfotiamine-3837	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.135
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.926564
BRD-K72298899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95323
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90406
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3657	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91383
GTEX-OOBJ-0526-SM-48TDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00654
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334659
methylbenzethonium chloride-2190	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-STAT3_target_genes_in_N1-GOPC_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56271
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79021
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3356
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
17683608-TableS3	GeneSigDB Published Gene Signatures	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1169
SARS-CoV_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.63428
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621429
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0175
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3903
BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EPHB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22403
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70544
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ERCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61786
Diabetes Mellitus, Type 1	HuGE Navigator Gene-Phenotype Associations	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91881
nes	HPA Cell Line Gene Expression Profiles	-1.0	-1.2446
SNU719	CCLE Cell Line Gene Expression Profiles	1.0	1.41074
CBY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0452
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04994
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38379
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07348252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08913
GTEX-PX3G-2426-SM-48TZZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890354
Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06365
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PRODH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03103
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12543
hsa-miR-152	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
BRD-K68836091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08243
BRD-K74522958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63915
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PPARA_agonist activation_GSE17251_474_human_Isolated hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KLF4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454685
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455945
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
WIPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52908
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3834
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML1-CLOSEST_GENE_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
H2818	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.59895
brain_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.998375
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874064
Anterior olfactory nucleus, external part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01459
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28264750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06675
GTEX-Q734-0226-SM-48U1A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0298
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14555
PMC10181932-41588_2023_1366_MOESM4_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_Additional_information_for_all_SOX9-dependent_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
AE-06-FY47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291774
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45768
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06851
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24354
GTEX-XAJ8-0226-SM-4GIB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13943
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GSE62843,GSE64370_0_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-20-LP90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281046
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84707727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01382
BE-42-IC00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223413
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87901124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65149
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04454
BRD-K01660763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86775
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02747
CP 94253	DeepCoverMOA Drug Mechanisms of Action	1.0	0.56
GSE144453,GSE144454_1_v_0_tfdp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279866
CMTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64876
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01625
NB7	GDSC Cell Line Gene Expression Profiles	-1.0	-2.53137
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.861064
organic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5471-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LHX1_KO_GDS2748_298_mouse_embryonic renal vesicles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
sotalol-4160	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.521458
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_B_BNC1	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.878278
15906272-Table4	GeneSigDB Published Gene Signatures	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.907477
RACK7-27058665-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_up-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.054
urapidil-6455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267488
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24589
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
homatropine-1848	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.695854
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.470686
alpha-estradiol-122	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gemfibrozil-5069	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14988
GSE228181_0_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00733
BRD-K10241968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03637
metabolic process	GO Biological Process Annotations 2015	1.0	null
proteolysis	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.933911
oxamniquine-4006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50400833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02289
FKRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01262
hsa-miR-128	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28192
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39794286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67639
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JL1	CCLE Cell Line Gene Expression Profiles	1.0	1.35714
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03061
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829241
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.25838
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12552
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5607
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Turner Syndrome_CNS - Brain (MMHCC)_GSE1606	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.34322
gabexate-4220	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7151
flucloxacillin-3128	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nde	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.990804
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K36me3_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.829683
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.973251
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02084
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Basomedial amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12517
eticlopride-5695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-423-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Precommissural nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19102
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Roxatidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18441
15474998-tableS1c	GeneSigDB Published Gene Signatures	1.0	null
A-VN-1203-2004(H5N1)_Day1-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.67517
hsa-miR-3666	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526258
LAMA2_Deficiency_GDS1778_747_mouse_Diaphragm (from dystrophia muscularis -dy/dy- mouse model)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
bicuculline-4397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468862
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05923
Sulfanilamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31727
NCIH1915	CCLE Cell Line Gene Expression Profiles	-1.0	-2.18933
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37788
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE151494_10_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-219-SOX7_SOX7	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.878278
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341418
BRD-K19766710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22114
SUZ12	ENCODE Transcription Factor Targets	1.0	null
BRD-K50942788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64484
proteolysis	GO Biological Process Annotations 2023	1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
PSMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55069
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRPF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83739
FMR1_KD_GDS4759_333_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.89104
GSE196505,GSE196507_3_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08241
Mean reticulocyte volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.95229
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.77794
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPA-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC9314667-Table_1.xlsx-Regulons-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13882
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34590335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11389
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852032
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.905718
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
streptomycin-1578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A50837272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77046
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76742876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25102
Perturb_4327_KO_Zcchc8_SRP187429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.14624
tiabendazole-2479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97366
PMC10130768-LSA-2023-01950_TableS5.xlsx-Genes_repressed_in_Primary_PCa-BAZ2A-TAM_repressed_in_BAZ2A_KDM1A__and_BAZ2A_TOP2A_High_primary_PCa_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
EEF1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30046
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88427
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6441-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dapsone-1868	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63575
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.06985
ikarugamycin-866	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7735
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52868251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01101
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.97577
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0826-SM-3GADQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13336
TAF1	ENCODE Transcription Factor Targets	1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:A12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7278
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-2.46196
hsa-miR-296-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35656
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-1926-SM-3P616	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08869
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6796-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.86549
GATA1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE178255_2_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DCTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77771
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129772_2_v_1_runx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58946
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918737
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K32839286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12296
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842104
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38466
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tafluprost	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
BRD-K34482448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42329
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ethaverine-5337	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K29771129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49061
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0226-SM-4BOP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929314
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S33H-0826-SM-4AD5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03582
Perturb_5101_KD_Dcaf11_SRP201454	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.72126
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02691
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850554
BD-48-JW52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299584
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844314
hsa-miR-4296	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1844
ChIP_SETDB1_19884255	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
clozapine-5589	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514208
pridinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24054
Lung adenocarcinoma_LUAD_TCGA-50-6593-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14168
BRD-K10812033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28221
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64698855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90972
Perturb_8895_KD_FGD5_SRP281196	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.4699
HMGN3	ENCODE Transcription Factor Targets	1.0	null
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.85941
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82335
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.981007
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988941
tetryzoline-6769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OOBJ-0926-SM-48TDO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913971
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17613
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.78051
TFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00966
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03229
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939058
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67256
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5672
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04285
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.23234
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1598
Perturb_17617_KO_TIP60_SRP386872	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.48063
GSE109111_2_v_0_stim1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38448
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306439
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942443
GTEX-PLZ6-1326-SM-3NB24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962306
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31727
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860333
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73988
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K87176777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05946
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE134608,GSE134609_2_v_6_dlx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.563142
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278234
BRD-K88960810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37435
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11424
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20291
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39735
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154577_6_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65988
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P0-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2215
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
revealed	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-3B-A9HJ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233722
BC-61-ZY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.411776
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38416
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66662
acetazolamide-1850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38121
BA-86-AL61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258537
SETDB1	ChEA Transcription Factor Targets	1.0	null
H3K9me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25988
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55C-1126-SM-48FCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831662
hsa-miR-3678-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sclerosing cholangitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23621
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.847
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02299
dorsal part of alar p3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63714
HUH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
atractyloside-4717	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54198
GSE199660_1_v_2_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97678
niclosamide-4136	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34311186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09179
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09709
medial habenular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02609
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854034
Perturb_4863_KD_BAF47_SRP188516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.48144
GTEX-S3XE-1026-SM-4AD4O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836569
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.868857
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25593
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.876394
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15137
thioproperazine-5791	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT6_01_85	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59626
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fluorouracil_homo sapiens_gpl550_zr-75-1_gds1627	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11792
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amrinone-4488	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05220907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08335
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6008
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137974
equilin-5255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88557
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25361
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39242
KMRC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWCY-1326-SM-48TCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917948
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXO1	ChEA Transcription Factor Targets	1.0	null
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Erythromycin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
BRD-K12015168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3643
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GOLGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56514
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.929677
fatty acid metabolic process	GO Biological Process Annotations 2015	1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22668
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-2.17254
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47Y-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10203545-Table_4.xlsx-LM7_underrepresented-DMRTA1_DMRTA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04205
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46727
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4P3-1526-SM-3K2AV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891332
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.02109
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.981859
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14476
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
I-kappaB/NF-kappaB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
harmaline-4968	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48823
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.491075
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.35599
CA-72-JV60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315625
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09247
BRD-K61651560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37594
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71191
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9547
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5982
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56439
GTEX-QV31-0126-SM-447BP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23776
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.01641
HS695T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67819
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid-primed multipotent progenitor cell(LMPP)_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r8Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38772
BRD-K07770425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97986
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04628
MZ in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.46222
peptidase activity	GO Molecular Function Annotations 2015	1.0	null
Gracile nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36083
KHM1B	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03083
BRD-K51003626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14128
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64866
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34885
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diphenhydramine-1871	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.79095
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4292	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
PKN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63217
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lymph node	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08984
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14992
BRD-K41700289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2279
BRD-K81779733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05574
BRD-K66748326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36043
Cystic Fibrosis_Intestinal Epithelium_GSE765	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.710221
BRD-K52124788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49591
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
chlorogenic acid-3282	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Platelet Component Distribution Width Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287712
hsa-miR-3184	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
BRD-K94476572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4183
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lambdoid septal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70485
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0041
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08725
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34391
U251	BioGPS Cell Line Gene Expression Profiles	1.0	0.861184
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31851055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65801
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2597
enlarged lymph nodes	MGI Mouse Phenotype Associations 2023	1.0	null
CALM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13612
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55147
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90887
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08398
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.969201
GSE184087_2_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265546
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1926
intermediate stratum of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57665
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45989
SMAD3-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC11213687-CLT2-14-e12379-s003.xlsx-Table_S3_-_Correlation-Table_S3_Summary_of_genes_that_significantly_correlated_with_NR1D2_PER2_or_PER3_in_at_least_4_out_of_5_datasets_NR1D2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K97562463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41369
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OVCAR-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48797
Perturb_3570_KO_RAB5C_SRP285142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.00715
GTEX-P4QT-0526-SM-2I3EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986049
NCIH2444	CCLE Cell Line Gene Expression Profiles	1.0	1.99403
19235837-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
MELAS - Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes_Muscle - Striated (Skeletal) (MMHCC)_GSE1462	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.95944
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851359
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
metalloexopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44837
COQ9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09394
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3073
diphenhydramine-1708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38018
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7631-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AF-12-IW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279063
PMC7614775-EMS178742-supplement-Proteomics_Table_2.pdf-172-IRF1_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47261
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00722
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.26578
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09071517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49182
BRD-K68086276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05974
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903712
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13194
SUDHL10	CCLE Cell Line Gene Expression Profiles	1.0	1.43245
thiethylperazine-6154	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trihexyphenidyl-4015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2224
hsa-miR-541	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19818
CPSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02652
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5113908-pone.0166185.s004.xlsx-Supp_1-Supplementary_Table_1_mRNA_expression_correlates_with_STAT3_phosphorylation_for_1279_genes_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97888
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366408
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222285
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.924314
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33105
sirolimus-1667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4315
STOCK1N-35874-6583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TADA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68617
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
felbinac-5700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6771-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4646-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CA-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10454
CRCGN015_MCF10A.WT.HP_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14575
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8253095-MOL2-15-1942-s005.xlsx-gene_lists-Genes_associated_with_H3K27ac-positive_sample_selective_AR_sites_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74803017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55796
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.861947
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hsa-miR-124-3p	MiRTarBase microRNA Targets	1.0	null
GSE186483_2_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A77G-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.890338
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
substantia innominata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.960872
GSE57871_8_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942739
trazodone-2379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LXF289	CCLE Cell Line Gene CNV Profiles	1.0	1.39026
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.00212
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54157
intermediate stratum of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79895
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pallidal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12343
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26263099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17806
dexpanthenol-1802	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NUP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01836
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19111
Perturb_3972_KD|Mut_SFPQ|BRAF_SRP258593	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.94202
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33487
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04966
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.054
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04813
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
5677_NIPBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635482
layer 1 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24284
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.882984
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KLE	CCLE Cell Line Gene CNV Profiles	1.0	2.30648
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869879
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91654
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60557007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09563
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59479
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895791
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.78285
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88201
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01131
BRD-K83586473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28924
hsa-miR-4731-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0782
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
haloperidol-6203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_3769_KD_GLI1_SRP042158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16579
alpha-ergocryptine-3900	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24406
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94849
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.85714
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BICR31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50846
PAX5	ENCODE Transcription Factor Targets	1.0	null
Perturb_5042_Mut_Adnp_SRP313259	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.64827
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	114.939
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05752
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A72E-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3888
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78997
C12orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4751
HM7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66307
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HS-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE84148,GSE96938_0_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.031
CHST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66518
MAZ	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4081-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04275703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20151
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986967
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.72488
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K05837079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34032
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0926-SM-4AD54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831417
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32944
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28939
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.974561
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04545
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31447
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193993_0_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91189798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36064
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0926-SM-2I5FA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950555
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892185
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02987
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23947
BRD-K21955645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00781
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0004
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13105
tissues	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05034
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33823
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3192	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891536
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-71-HES6_HES6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GW-8510-7085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73296134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66184
BRD-K72843176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12222
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PLK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00114
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.59184
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78971
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29068
dinoprost-2446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_KO_GSE39009_49_mouse_skeletal muscle (6 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69914820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35855
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S341-1626-SM-3K2B8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894841
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6759_KO|KD_IER5_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.70107
BRD-K47658117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0068
BRD-K39710695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6077
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57404319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55274
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3190	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235555
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
(S)-Selisistat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83935370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5289
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.50468
hsa-miR-148a	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828267
Perturb_5340_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP337936	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.72447
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18027
ajmaline-7484	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT4-19710469-TH1 cell mouse-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66939340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1673
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33653343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03443
BRD-K71893034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52597
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-520-ENSG00000144485_HES6	Rummagene Transcription Factor Associations 2026	1.0	null
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.95019
bepridil-5674	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LY-294002-5213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
xamoterol-3401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977904
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.895741
promazine-2173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.01579
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83652
GSE215086_3_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Posterior amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23152
Lung adenocarcinoma_LUAD_TCGA-86-8672-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88071
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.845462
pRb_Deficiency_GDS3176_605_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07386
ETS1	ENCODE Transcription Factor Targets	1.0	null
Posterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42145
BRD-K17885598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08315
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PABIR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04484
BRD-K83934572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07564
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86601
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20712
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315882
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6047
LY-294002-5236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chlorhexidine-6302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QE-00-EB96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200871
alvespimycin-5210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.860042
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.593
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.64557
AE-71-CB15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210071
BRD-K14216332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65901
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253942
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6428
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0726-SM-2I3EB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851298
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null