association	dataset	threshold value	standardized value
EIF4A3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01577807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16205
DPM1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7015
IL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00763135
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02333
BRD-K99452971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69585
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MRPL9	Pathway Commons Protein-Protein Interactions	1.0	null
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
RPS19	Pathway Commons Protein-Protein Interactions	1.0	null
SENP7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16563
EP300	ENCODE Transcription Factor Targets	1.0	null
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6347
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256372
Metabolism of proteins	Reactome Pathways 2024	1.0	null
OPHN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K68540120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98353
JUN	Pathway Commons Protein-Protein Interactions	1.0	null
NSUN2	Pathway Commons Protein-Protein Interactions	1.0	null
KRT2	Pathway Commons Protein-Protein Interactions	1.0	null
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.647035
YTHDF3	Pathway Commons Protein-Protein Interactions	1.0	null
AHNAK2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11457257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39531
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74505
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924136
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POP4	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.507
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A633-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.978289
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7955
PMC6428271-pone.0213813.s007.xlsx-LPS_significant_PPIs-node1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CXCL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669433
ZNF324	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17232330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07046
MED12L	Pathway Commons Protein-Protein Interactions	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
cellular component disassembly	GO Biological Process Annotations 2015	1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05928
ATP6V1D	Pathway Commons Protein-Protein Interactions	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052829
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66441
skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096848
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.096
GATA3	ENCODE Transcription Factor Targets	1.0	null
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.59915
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369679
FAM117B	Pathway Commons Protein-Protein Interactions	1.0	null
769-P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7837
BD-60-DR81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203614
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90553
PLCD3	Pathway Commons Protein-Protein Interactions	1.0	null
IL36RN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642944
GEMIN2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95537020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08388
BRD-K02708799_GSK-1059615_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DNAJC13	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16121
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GLTSCR2	Pathway Commons Protein-Protein Interactions	1.0	null
DYX1C1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48641
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.573168
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST3H2BB	Pathway Commons Protein-Protein Interactions	1.0	null
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.41085
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721421
HS-68 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6014302__F4	PFOCR Pathway Figure Associations 2024	1.0	null
RPL13	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KRT14	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61942
LY86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640648
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84867
VSIG10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45339
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.211587
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1201
ZNF585B	Pathway Commons Protein-Protein Interactions	1.0	null
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.875677
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
TSPAN14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610041
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50552
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.850262
MRPL15	Pathway Commons Protein-Protein Interactions	1.0	null
LGALS3BP	Pathway Commons Protein-Protein Interactions	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
RPL10L	Pathway Commons Protein-Protein Interactions	1.0	null
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MSH3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33534
PARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3764
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.567085
Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218289
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0089
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CPT1A	Pathway Commons Protein-Protein Interactions	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377747
HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
esophagus	HPA Tissue Protein Expression Profiles	1.0	0.723381
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
HSD17B10	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14144134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40887
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.83433
KIAA0922	Pathway Commons Protein-Protein Interactions	1.0	null
Influenza Infection	Reactome Pathways 2014	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35326
epididymis	HPA Tissue Protein Expression Profiles	1.0	0.723381
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K27372445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67942
MDA-MB-436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NUDT16L1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972349
ZNF740	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22671
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18602
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13212
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF264	Pathway Commons Protein-Protein Interactions	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363919
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68729
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15493
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
METTL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0167
CNP	Pathway Commons Protein-Protein Interactions	1.0	null
cytosolic large ribosomal subunit	GO Cellular Component Annotations 2023	1.0	null
NAGPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609123
BRD-K46155894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11591
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76372
IL2RG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579721
KRTAP5-8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515808
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07252
RFX5	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2518
PPP2CB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26447
BL5826 (ORC6L)	NURSA Protein Complexes	1.0	null
BRD-K14732815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08892
yy2_20215434_hela_lof_human_gpl570_gds3788	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.052092
ribosomal large subunit biogenesis	GO Biological Process Annotations 2023	1.0	null
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.97615
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11577
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TV-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DHX8	Pathway Commons Protein-Protein Interactions	1.0	null
4271_KANSL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.570092
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055182
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943897
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FLT4_knockdown_103_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.47656
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.937897
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961917
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422349
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824537
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
PMC11880379-41467_2025_57480_MOESM3_ESM.xlsx-FOXP1_RIME_Limma-Gene_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36382446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01521
NELFB	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.0128
HGC-27	GDSC Cell Line Gene Expression Profiles	1.0	1.758
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIF2 (NCOA2)	NURSA Protein Complexes	1.0	null
7452_RPL26L1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.14852
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52988
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3114_FLVCR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.689113
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42488
6280_PHF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.559314
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6694
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31595
ATP5F1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NAIP	Pathway Commons Protein-Protein Interactions	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80763723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28428
BRD-K73210450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02081
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.292897
HMGB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17140735_-666_A549_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K43025624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27807
Acute Myeloid Leukemia_LAML_TCGA-AB-2856-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GFPT1	Pathway Commons Protein-Protein Interactions	1.0	null
ZC3H11A	Pathway Commons Protein-Protein Interactions	1.0	null
LYAR	Pathway Commons Protein-Protein Interactions	1.0	null
FGFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47569
ZFP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-Fig7e-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.97202
BRD-K38617061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26282
ASPH	Pathway Commons Protein-Protein Interactions	1.0	null
SRP-dependent cotranslational protein targeting to membrane	Reactome Pathways 2014	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25645002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70706
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23494
BRD-K26790127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01576
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12507
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07564
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
BL5529 (CCDC99)	NURSA Protein Complexes	1.0	null
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20451745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02602
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.28
SREK1	Pathway Commons Protein-Protein Interactions	1.0	null
DPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04404
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13113551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15842
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346055
XAB2	Pathway Commons Protein-Protein Interactions	1.0	null
Ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.981311
IGSF8	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1793
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00594484
BRD-K47254434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34255
MARCKS	Pathway Commons Protein-Protein Interactions	1.0	null
MGST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00699178
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A3OT-06A-23R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRPEL1	Pathway Commons Protein-Protein Interactions	1.0	null
DECR1	Pathway Commons Protein-Protein Interactions	1.0	null
FANCM	Pathway Commons Protein-Protein Interactions	1.0	null
AB-39-ED84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281261
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500075
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38396
BRD-K48188521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27905
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
protein transport	GO Biological Process Annotations 2015	1.0	null
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62301
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825062
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226594
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3797
BC-26-LE04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352776
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.13545
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17658
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17514980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15138
BRD-K82284644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36564
LSM6	Pathway Commons Protein-Protein Interactions	1.0	null
RCC4	CCLE Cell Line Gene CNV Profiles	1.0	1.6278
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0639
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic transport	GO Biological Process Annotations 2015	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.707252
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40564
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.23113
PEX11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57445
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49542
ALDH3A2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55489373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30011
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4396_KD_SUV39H1_SRP290196	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935098
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.5568
skin_5f	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14962
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59523233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59219
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.672039
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.096
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2143
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.18324
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.786
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11782435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5186
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11747
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.867584
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69847
GRWD1	Pathway Commons Protein-Protein Interactions	1.0	null
CUL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00710508
nucleoplasm part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.057696
SP2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.896842
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70181
FUBP1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Flotillin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.7
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19044
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898675
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NIPBL	Pathway Commons Protein-Protein Interactions	1.0	null
FNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K97537859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34184
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43653
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6831
HASPIN	Kinase Library Serine Threonine Kinome Atlas	1.0	null
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4087
smoothmuscle_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.845086
POLD1	Pathway Commons Protein-Protein Interactions	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396845
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.530505
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DSN1	Pathway Commons Protein-Protein Interactions	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K94962552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03567
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.960264
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7567
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3848
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.511941
CD3EAP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE211128_9_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062871
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_24-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
BAG4	Pathway Commons Protein-Protein Interactions	1.0	null
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
PRR14	Pathway Commons Protein-Protein Interactions	1.0	null
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0063
SHMT2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K51253991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28541
BRD-K57556489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35194
BRD-K80766355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12463
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF566	Pathway Commons Protein-Protein Interactions	1.0	null
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CTB-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.77908
AHCY	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29083
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.996546
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70271
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53915
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.78637
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Pepstatin A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
RRP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92825272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82158
7403_RNMT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510355
POLR2H	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72542
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5839
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
SETDB1_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ribosome	KEGG Pathways 2026	1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTSA	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64567246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39418
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYO18A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LSM3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47821225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6242
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04734
MAGI1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12975
CXCL8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00786246
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91609
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNRPE	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9212
Influenza Viral RNA Transcription and Replication	Reactome Pathways 2024	1.0	null
TPCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27227
KLF10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11647
PPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57542
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053369
DDX18	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42013
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324646
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K22173206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15021
PNN	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.91196
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865323
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.92723
LARS	Pathway Commons Protein-Protein Interactions	1.0	null
ZRANB2	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEC23B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23316938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20317
DDX51	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05350978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10207
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830483
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4954
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41117
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243815
EST1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF625	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS12	Pathway Commons Protein-Protein Interactions	1.0	null
RPL13A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887302
CYBA	Pathway Commons Protein-Protein Interactions	1.0	null
BL4516 (ATRX)	NURSA Protein Complexes	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244589
SLC25A10	Pathway Commons Protein-Protein Interactions	1.0	null
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2AD	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1002
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68616
COPI-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
BRD-K86454955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23788
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_InDel-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
large ribosomal subunit	GO Cellular Component Annotations 2025	1.0	null
BRD-K50094173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38447
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.856279
MDH2	Pathway Commons Protein-Protein Interactions	1.0	null
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
COLO668	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34333
BRD-K40103182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03669
multi-organism cellular process	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9405
BRD-K72792753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65948
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C14orf166	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LSM2	Pathway Commons Protein-Protein Interactions	1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
ZC3H4	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEP170	Pathway Commons Protein-Protein Interactions	1.0	null
Tiagabine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UI-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL36	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYNU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061852
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SERPINH1	Pathway Commons Protein-Protein Interactions	1.0	null
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398828
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.512862
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7243_REXO2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500017
BL436 (NCOA2)	NURSA Protein Complexes	1.0	null
RFC5	Pathway Commons Protein-Protein Interactions	1.0	null
EPB41L2	Pathway Commons Protein-Protein Interactions	1.0	null
ribosome biogenesis	GO Biological Process Annotations 2023	1.0	null
PTRF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00966
TPH1	Pathway Commons Protein-Protein Interactions	1.0	null
diamond-blackfan anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.87102
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.777136
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PLRG1	Pathway Commons Protein-Protein Interactions	1.0	null
ADAR	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0738
ACLY	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4384327-12859_2014_432_MOESM6_ESM.pdf-2-DNMT1_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.99174
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961393
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERGIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75805
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930282
HDAC1	ENCODE Transcription Factor Targets	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7219
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62984
RBM42	Pathway Commons Protein-Protein Interactions	1.0	null
NPLOC4	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
BRD-K84235037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1992
PNO1	Pathway Commons Protein-Protein Interactions	1.0	null
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KBTBD6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K51927648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71462
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.439633
CBS	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2BO	Pathway Commons Protein-Protein Interactions	1.0	null
TRPM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490333
GTEX-OOBK-2025-SM-3LK5S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936736
SF3B4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13533
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.867584
DDX39B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89465
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3637
YDJC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694163
UF-28-DW05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.702998
KDM4A	ENCODE Transcription Factor Targets	1.0	null
ORC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00432211
NCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00438395
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS13	Pathway Commons Protein-Protein Interactions	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04122
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gene Expression	Reactome Pathways 2014	1.0	null
ROBO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583812
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.817359
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VSTM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486651
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12922
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31526
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.975324
PMC6014302__F4	PFOCR Pathway Figure Associations 2023	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM214	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13089
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.07769
GNL2	Pathway Commons Protein-Protein Interactions	1.0	null
SLC6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585635
BRD-K61021741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0284
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Navarixin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.104
BRD-K37276417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50343
SA-03-IQ14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292872
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.610792
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.856799
CBX1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131660_1_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K36me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYRIA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547081
PPP2R3B	Pathway Commons Protein-Protein Interactions	1.0	null
mrna catabolic process	GO Biological Process Annotations 2015	1.0	null
FASTKD2	Pathway Commons Protein-Protein Interactions	1.0	null
bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.10889
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.884094
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPTX2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346127
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72773309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27554
GTEX-UJHI-0008-SM-4IHL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835991
MRPS31	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29709
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86203
AJAP1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0182
NAP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
CTR9	Pathway Commons Protein-Protein Interactions	1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98453
RPSA	Pathway Commons Protein-Protein Interactions	1.0	null
SLC5A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68375
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056517
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.26335
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	3.01008
MRPS14	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56283394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76109
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53074
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8454
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71944493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78163
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5689
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.32083
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00829
DNAJA1	Pathway Commons Protein-Protein Interactions	1.0	null
PSME3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972708
BRD-A70155556_NP-001236_HA1E_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26762
TEX2	Pathway Commons Protein-Protein Interactions	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.869306
CRCGN017_MCF10A.WT.HP_24H:I09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6919
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.27026
DSH1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67781
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02414
BRD-K16802067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25631
GSE200897_1_v_0_pold1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BL7477 (CHTF18)	NURSA Protein Complexes	1.0	null
BRD-K58643762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00848
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.49583
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EIF3D	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160817_2_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARRB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14417813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49525
lymph node	HPA Tissue Protein Expression Profiles	1.0	0.723381
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869144
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454055
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44083
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.95357
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31577322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41202
BRD-K19755525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07981
BRD-K71296038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03965
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZC3H13	Pathway Commons Protein-Protein Interactions	1.0	null
BL5941 (WNK1)	NURSA Protein Complexes	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33713
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.92673
single-organism intracellular transport	GO Biological Process Annotations 2015	1.0	null
BRD-K12867546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27785
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44821
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31521981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19665
ELK1	ENCODE Transcription Factor Targets	1.0	null
TRMT61A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80803211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50675
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
OE-78-XD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.408441
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.46126
PMC6089552-oncotarget-09-31018-s004.xlsx-compound_targets_chip_rnaseq-Chip-seq_derived_EWS-FLI1_targets_Bilke_et_al_2013_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57788
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BL3602 (TP53BP2)	NURSA Protein Complexes	1.0	null
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
OBSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34674
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.842737
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83915
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.67157
BRD-K45819372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05229
DNAJC5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0074208
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36874
UACC257	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.949646
IRAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572966
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35977
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
PRPF4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26084
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF15	Pathway Commons Protein-Protein Interactions	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852077
SLTM	Pathway Commons Protein-Protein Interactions	1.0	null
CIRBP	Pathway Commons Protein-Protein Interactions	1.0	null
Ulcerative colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
KANK2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10232513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3388
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
structural constituent of ribosome	GO Molecular Function Annotations 2015	1.0	null
ZPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09773
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.28
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9031
POLG	Pathway Commons Protein-Protein Interactions	1.0	null
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.97592
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12114
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE5370	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.39032
BRD-K29806938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27409
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87931
BRD-K02946901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19126
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-FigS7d-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.06877
SDHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484143
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
RET_druginhibition_184_GSE49414	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.658
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205333
BCAS2	Pathway Commons Protein-Protein Interactions	1.0	null
HCV JFH-1_18Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.21103
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22226
BRD-K96981233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61799
CROCC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135350_3_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21789048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17582
RPS27L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF703	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K97257286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02377
BRD-K76618080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31944
BYSL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61027868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26409
SLC27A2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45056520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24694
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.15843
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEC31B	Pathway Commons Protein-Protein Interactions	1.0	null
COLO741	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44142
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30471
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607706
BRD-K63716942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29911
PPP3R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561348
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55472
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11955
umbilical cord blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K91469267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32089
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KW-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLSTN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTF3C2	Pathway Commons Protein-Protein Interactions	1.0	null
KRT16	Pathway Commons Protein-Protein Interactions	1.0	null
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSTP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DB-40-HA40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204941
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
SP2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04378630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45023
BL117 (ATR)	NURSA Protein Complexes	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9262
BRD-K82768815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36611
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
DMS153	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72124
Large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
VNN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592412
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.150502
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052753
catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957582
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26718
UTP3	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58889
TXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00474394
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33503286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76927
BRD-K77535986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63323
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157557,GSE157559_1_v_0_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC86	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K74870161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0507
H2AFV	Pathway Commons Protein-Protein Interactions	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.778086
TUBA1B	Pathway Commons Protein-Protein Interactions	1.0	null
UFL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56650430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58618
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9865
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10434
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A1CF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K64800655_PHA-793887_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6538_POLR1D_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.619482
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecular complex disassembly	GO Biological Process Annotations 2015	1.0	null
KIAA0020	Pathway Commons Protein-Protein Interactions	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29614616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00303
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.684
BCL3	ENCODE Transcription Factor Targets	1.0	null
GAR1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51979
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843391
TDG	Pathway Commons Protein-Protein Interactions	1.0	null
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
EBF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524173
DNAJC9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44224150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22624
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3272
PRR11	Pathway Commons Protein-Protein Interactions	1.0	null
ART5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35977
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57624
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881338
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45713
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.852505
BRD-K14942405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.78394
BRD-K56783915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63239
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941581
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.39894
HSP90AA2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7391
DEDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28631
multi-organism process	GO Biological Process Annotations 2015	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965439
NUDT1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25056
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02481
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12865
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13190943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35027
UBE2R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36596
RBM28	Pathway Commons Protein-Protein Interactions	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43Y-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USP36	Pathway Commons Protein-Protein Interactions	1.0	null
preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.0873
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2011
MPO	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2791-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM120A	Pathway Commons Protein-Protein Interactions	1.0	null
PGD	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Viral mRNA Translation	Reactome Pathways 2014	1.0	null
heterocycle catabolic process	GO Biological Process Annotations 2015	1.0	null
DDX47	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76450502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30805
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10276
NEK9	Pathway Commons Protein-Protein Interactions	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876802
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
QPCTL	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUBN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495527
IL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00798678
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.942376
Perturb_5942_KD_PIAS2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.72251
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75008
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RALGAPA1	Pathway Commons Protein-Protein Interactions	1.0	null
CNBP	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32609
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28755
IZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.958275
BRCA1	ENCODE Transcription Factor Targets	1.0	null
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886687
CTCF	ENCODE Transcription Factor Targets	1.0	null
ADH1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713268
NME4	Pathway Commons Protein-Protein Interactions	1.0	null
HPRT1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41524
BRD-K03851221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00912
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
rRNA processing	Reactome Pathways 2024	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24582
CUL1	Pathway Commons Protein-Protein Interactions	1.0	null
ATAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525419
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91354
BRD-K90571714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13248
BRD-K40674409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62574
CPSF2	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06353
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60972
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11473
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54790089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05676
BRD-K89952634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12327
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EIF2S1	Pathway Commons Protein-Protein Interactions	1.0	null
HSP90B1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_2D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72685049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12775
HIRA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K09473191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29335
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.851097
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93844
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THOC6	Pathway Commons Protein-Protein Interactions	1.0	null
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
BRD-K73695595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22324
BRD-K36566880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36727
BRD-K12709183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39649
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23096
RPL37A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1567
KMT2E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553248
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AMY2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058774
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85988
cellular macromolecule localization	GO Biological Process Annotations 2015	1.0	null
SLR25	CCLE Cell Line Gene CNV Profiles	1.0	2.29538
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5705
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20541
BRD-K50479239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02175
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988301
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCAI	Pathway Commons Protein-Protein Interactions	1.0	null
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8821
aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.20829
SRSF4	Pathway Commons Protein-Protein Interactions	1.0	null
CAMSAP3	Pathway Commons Protein-Protein Interactions	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056076
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9021
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H9	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52083
ZC3H18	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233183,GSE233187_3_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCT-116	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.65349
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAST4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81522725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37943
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00795
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HPSE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49824
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09518
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NPC1L1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72658
CNOT4	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
PRDX4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882305
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92717
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03101
SMARCC1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF620	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
FLCN	Pathway Commons Protein-Protein Interactions	1.0	null
PREX2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14828
PPP1R18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06709
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330857
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1136
HIST1H2BK	Pathway Commons Protein-Protein Interactions	1.0	null
SLK	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2671
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56593
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957381
BRD-K17300786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06643
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05743
EXOSC5	Pathway Commons Protein-Protein Interactions	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.926718
Lung squamous cell carcinoma_LUSC_TCGA-77-7138-01A-41R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
umbilical cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
METRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33216
SH3RF1	Pathway Commons Protein-Protein Interactions	1.0	null
FRMD6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A18763547_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07388
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08798
AGBL1	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21266
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.944295
nuclear-transcribed mrna catabolic process	GO Biological Process Annotations 2015	1.0	null
RELL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055689
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07631
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAP7D3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
t-UTP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.727
MYO1F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00813343
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SRRT	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85574
BRD-K90526956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52084
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02253
ARID5B	Pathway Commons Protein-Protein Interactions	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SACS	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GABRR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913636
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8399
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41761
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58892587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13807
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847717
BRD-K92356505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48088
ATF2	ENCODE Transcription Factor Targets	1.0	null
RPLP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15493
BEN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.78394
AD-89-ID99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289363
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00776
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3436-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MIS12	Pathway Commons Protein-Protein Interactions	1.0	null
EIF2S2	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C19orf53	Pathway Commons Protein-Protein Interactions	1.0	null
7816_SETD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.542999
SMTN	Pathway Commons Protein-Protein Interactions	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45988
MKL1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982733
AQR	Pathway Commons Protein-Protein Interactions	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288229
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04612
GABRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476269
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13824
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC1A3	Pathway Commons Protein-Protein Interactions	1.0	null
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MEL-3	GDSC Cell Line Gene Expression Profiles	1.0	2.10844
organic cyclic compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04246
EIF4B	Pathway Commons Protein-Protein Interactions	1.0	null
ESR1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.79899
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.723381
SRSF7	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348648
AE-06-JY57_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.722775
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PLK1	Pathway Commons Protein-Protein Interactions	1.0	null
blood vessel	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NUSAP1	Pathway Commons Protein-Protein Interactions	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.00666
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34677894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26748
CE-15-YU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229336
BRD-K86587289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21718
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRPF3	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3H	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36252987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52516
GTEX-PLZ6-0226-SM-3P61I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851062
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05194
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.727376
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06457
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BL2533 (OBFC1)	NURSA Protein Complexes	1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6323
RNASEH1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13759
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31764
PBXIP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9433
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-5142-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.42516
LUC7L3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31250130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41843
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
swi/snf superfamily-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.174361
intracellular part	GO Cellular Component Annotations 2015	1.0	null
DDX27	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64698
IFNA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00876049
nuclear part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46401069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02683
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296427
SNRPB2	Pathway Commons Protein-Protein Interactions	1.0	null
ALAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0028254
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	1.71644
CTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77548697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07771
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16938
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid	DrugBank Drug Targets	1.0	null
BMS1	Pathway Commons Protein-Protein Interactions	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
MAP7D1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0531
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.54762
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03249
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2664
RRP1B	Pathway Commons Protein-Protein Interactions	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SAP30	ENCODE Transcription Factor Targets	1.0	null
MB-49-LL22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20049
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CDK2AP1	Pathway Commons Protein-Protein Interactions	1.0	null
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04277
hsa-miR-203	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CCDC9	Pathway Commons Protein-Protein Interactions	1.0	null
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3057
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85793
RPS17	Pathway Commons Protein-Protein Interactions	1.0	null
HSPH1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K15876355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95434
CAPRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3M	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24838542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29043
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5987
BRD-K59957885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10754
BRD-K22720379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80796
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15400067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44997
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0609
TRMT6	Pathway Commons Protein-Protein Interactions	1.0	null
HIST2H2AC	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37048
PRRC2C	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051036
PRKCZ	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
KALRN	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95048194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11692
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15436
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.26312
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00483
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K87532481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42744
SF3B2	Pathway Commons Protein-Protein Interactions	1.0	null
EIF5A	Pathway Commons Protein-Protein Interactions	1.0	null
PAN2	Pathway Commons Protein-Protein Interactions	1.0	null
ELK1	ChEA Transcription Factor Targets	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTCD3	Pathway Commons Protein-Protein Interactions	1.0	null
UPF1	Pathway Commons Protein-Protein Interactions	1.0	null
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Reactome Pathways 2014	1.0	null
BRD-K19378563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49021
ZNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07877
BRD-K91399333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09786
HIST1H1C	Pathway Commons Protein-Protein Interactions	1.0	null
CUL3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21355275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45414
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
CTSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00318003
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27361
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9248
STBD1	Pathway Commons Protein-Protein Interactions	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MSH2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87465930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79209
MALME3M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51454
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86165
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18495
OVCAR-4	GDSC Cell Line Gene Expression Profiles	1.0	2.00159
Acute Myeloid Leukemia_LAML_TCGA-AB-3002-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2833-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRA2B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15279
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3933
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.906725
nucleobase-containing compound catabolic process	GO Biological Process Annotations 2015	1.0	null
MYO1D	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM109	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6428271-pone.0213813.s007.xlsx-LPS_significant_GOs-ensembl_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q3-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gene expression	GO Biological Process Annotations 2015	1.0	null
HMGB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41287744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29234
ZSWIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07061
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PPA2	Pathway Commons Protein-Protein Interactions	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22734
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608644
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
OVOL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56116
MAP4	Pathway Commons Protein-Protein Interactions	1.0	null
NUP98	Pathway Commons Protein-Protein Interactions	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524653
DNAJB12	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OccipitalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.971272
ME2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83325
Eukaryotic Translation Elongation	Reactome Pathways 2014	1.0	null
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26064
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60393
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP2	ENCODE Transcription Factor Targets	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40512
BRD-K91866516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95298
Nonsense-Mediated Decay (NMD)	Reactome Pathways 2024	1.0	null
VF-79-GQ03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269545
LU-99A	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
METTL16	Pathway Commons Protein-Protein Interactions	1.0	null
DIP2B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF585A	Pathway Commons Protein-Protein Interactions	1.0	null
MOV10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.028
BRD-K22380647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36033
BRD-K43126701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37311
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNRNP40	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75267
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.61044
BRD-K92579151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0158
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04575
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2918
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29816
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1518
SUP-T1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.32938
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6561
congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.38254
CGTHW1	CCLE Cell Line Gene CNV Profiles	1.0	1.51431
BRD-K69718434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91172
HIST1H2BL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89142472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40712
DACH1	ChEA Transcription Factor Targets	1.0	null
hmc1	HPA Cell Line Gene Expression Profiles	-1.0	-1.50828
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KAT2B	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TUBB3	Pathway Commons Protein-Protein Interactions	1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259077
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948698
USP19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00473822
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262554
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0572
Diamond-Blackfan anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Pure red-cell aplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61963
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.635199
SNRPG	Pathway Commons Protein-Protein Interactions	1.0	null
SDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546351
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42245
ARID4B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57786028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13904
BRD-K21327356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0741
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861168
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09122
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532374
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84549
SF1	Pathway Commons Protein-Protein Interactions	1.0	null
LOX	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407216
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14398
MAGEB10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10197
Adrenocortical carcinoma_ACC_TCGA-OR-A5LM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF510	Pathway Commons Protein-Protein Interactions	1.0	null
PLA2G12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7643
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00761
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6428271-pone.0213813.s007.xlsx-LPS_significant_PPIs-node2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PPP2R5E	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.114
LGMN	Pathway Commons Protein-Protein Interactions	1.0	null
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1048
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.42766
TSR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67674
AC-36-SY22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553387
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07774
SDAD1	Pathway Commons Protein-Protein Interactions	1.0	null
cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.117623
ALDH3A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718337
BRD-K79732056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56005
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESRP2	Pathway Commons Protein-Protein Interactions	1.0	null
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24187
KARPAS-45	GDSC Cell Line Gene Expression Profiles	-1.0	-2.02682
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1851
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10043
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39676
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.933129
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.253639
CEP55	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1715
PIGV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511889
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31917106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2726
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00744507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38192
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958158
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6468
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16377
UBTF	ENCODE Transcription Factor Targets	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.894
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.880926
CTCF_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL409 (UPF1)	NURSA Protein Complexes	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PKP3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
BRD-K46526566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01713
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36386
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09525
Disease	Reactome Pathways 2024	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26769
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GCT	CCLE Cell Line Gene CNV Profiles	1.0	1.34976
FOXF2	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
LARP1	Pathway Commons Protein-Protein Interactions	1.0	null
Cholinergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400102
RPL35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19956
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914038
rna biosynthetic process	GO Biological Process Annotations 2015	1.0	null
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39104
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.36259
GAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04462
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92604
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490068
CLEC7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00423164
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
NDUFA4	Pathway Commons Protein-Protein Interactions	1.0	null
SC-81280 (NCOA2)	NURSA Protein Complexes	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K63960902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08423
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606633
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
YY1	ENCODE Transcription Factor Targets	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08927
hsa-miR-1537	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
PUF60	Pathway Commons Protein-Protein Interactions	1.0	null
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206137
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55256232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09792
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.786
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCT8	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044125
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
AKAP1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08107
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20898
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
KCNN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532262
GPATCH4	Pathway Commons Protein-Protein Interactions	1.0	null
RNF212	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00517988
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18943
NUTM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00693805
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23543737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81489
Umbilical cord blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MZ in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.835847
BRD-K61087440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04127
anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.812232
ARG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606324
MCCC1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4873-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABARAPL2	Pathway Commons Protein-Protein Interactions	1.0	null
PPIE	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43298189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11953
PMC12271601-mmc2.xlsx-OUT_cells_01-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
AHDC1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LRIF1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32696
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K02240568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01004
BRD-K50046044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07973
appendix	HPA Tissue Protein Expression Profiles	1.0	0.723381
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.975493
ZNF829	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.678834
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10056
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285376
NCIH1648	CCLE Cell Line Gene CNV Profiles	1.0	1.3662
BOD1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65882
BRD-K74267000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09722
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKIV2L2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TROVE2	Pathway Commons Protein-Protein Interactions	1.0	null
CNTN5	Pathway Commons Protein-Protein Interactions	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317766
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873666
IZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14545
BRD-K76515685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04389
Intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.786
Cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.005
7820_SETD6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.715331
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29366596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83902
Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Developmental Biology	Reactome Pathways 2024	1.0	null
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35741
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00319
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874979
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cotranslational protein targeting to membrane	GO Biological Process Annotations 2015	1.0	null
BRD-K42809349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47099
GRPEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30615
NCI-SNU-16	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56896
ATM	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936747
BRD-K66470464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08463
Keratohyalin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
BRD-K05992469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40387
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2490_EEF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567668
HIST2H2AA4	Pathway Commons Protein-Protein Interactions	1.0	null
ADSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00398361
single-organism process	GO Biological Process Annotations 2015	1.0	null
BRD-K25177502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14836
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91438
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LSM7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K79090631_CGP-60474_MCF10A_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SF3B1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12146
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3838
VSIG10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537015
EXOSC6	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stomach	HPA Tissue Protein Expression Profiles	1.0	0.723381
NCIH1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39571
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.871846
ARHGAP24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679424
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9239
RPA3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92358687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46659
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5726
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC26	Pathway Commons Protein-Protein Interactions	1.0	null
APBB1IP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625776
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESF1	Pathway Commons Protein-Protein Interactions	1.0	null
STAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565448
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56301498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91299
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.94703
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870766
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNRNPLL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87839
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RA-49-ZB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25762
CRCGN008_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76365
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8548
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.74021
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL5747 (FKBP4)	NURSA Protein Complexes	1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.99838
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38814
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3101_FKBP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.547946
SRSF12	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94977
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855399
RBBP7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41334119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43464
RPS20	Pathway Commons Protein-Protein Interactions	1.0	null
TestisLeydigCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.23164
AIFM2	Pathway Commons Protein-Protein Interactions	1.0	null
MED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45128
BC-72-DZ30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540816
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.196012
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2466
A549_LUNG	CCLE Cell Line Proteomics	1.0	10.7425
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABCA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00762446
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02295
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8842_TFCP2L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546477
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.847556
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ITGAL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593039
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNPS1	Pathway Commons Protein-Protein Interactions	1.0	null
PC-18-VX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232341
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.694349
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18092
NPR1	Pathway Commons Protein-Protein Interactions	1.0	null
SNAPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43787
496100378_TCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.13424
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
establishment of protein localization to organelle	GO Biological Process Annotations 2015	1.0	null
Perturb_6306_KD_UBE2CP3_SRP299256	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.0941
BRD-K21680192_mitoxantrone_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24311
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323131
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ozagrel	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983651
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERBIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612979
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS3A	Pathway Commons Protein-Protein Interactions	1.0	null
KOW	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K13514097_S1120_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PEG3	Pathway Commons Protein-Protein Interactions	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1799
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
TRPM1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8897
SF3A3	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04666
XPA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58756877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24601
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964267
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999342
BRD-K33461572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03976
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7692-01A-12R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2828_RAMAC_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28697
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1169
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDX56	Pathway Commons Protein-Protein Interactions	1.0	null
YBX3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5GA-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K83949633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19765
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209388
IZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901333
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21811
INSM1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
aromatic compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04492
GSK3B	Pathway Commons Protein-Protein Interactions	1.0	null
(S)-Zopiclone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.2
ABCB1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44824
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63809385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51511
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14699
BRD-K43295075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38698
BRD-K93491540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91611
BL5913 (NUCKS1)	NURSA Protein Complexes	1.0	null
HSPA1L	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SRP9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FI-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51913
PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
MARK2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRMT112	Pathway Commons Protein-Protein Interactions	1.0	null
HS578T	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.61438
POLR2C	Pathway Commons Protein-Protein Interactions	1.0	null
RPS5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE166783_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cap-dependent Translation Initiation	Reactome Pathways 2014	1.0	null
HDLM2	CCLE Cell Line Gene CNV Profiles	1.0	1.46047
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.82124
ELMSAN1	Pathway Commons Protein-Protein Interactions	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32923
SQRDL	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.871783
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056395
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998521
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.65068
organic substance transport	GO Biological Process Annotations 2015	1.0	null
TNFRSF18	Pathway Commons Protein-Protein Interactions	1.0	null
LGALS1	Pathway Commons Protein-Protein Interactions	1.0	null
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
NKRF	Pathway Commons Protein-Protein Interactions	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222335
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891767
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84192
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
SKMEL3	CCLE Cell Line Gene CNV Profiles	1.0	1.56662
CD24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621785
CNN3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K15675930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88183
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YTHDC1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.68535
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRIK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00688121
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205657
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GNL3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36848506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93542
DLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12971
UHRF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65969715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31614
ZNF143	ENCODE Transcription Factor Targets	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.512862
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATAD3A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20696416_NVP-AEW541_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AC-55-XA97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402682
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
NB69	GDSC Cell Line Gene Expression Profiles	1.0	1.94711
MSI2	Pathway Commons Protein-Protein Interactions	1.0	null
bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.350372
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.104
PIP5K1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00436558
ELFN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76803075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0655
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
KMT2A	Pathway Commons Protein-Protein Interactions	1.0	null
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.20997
NFIL3	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8177-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
308_ANAPC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.619392
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24243
LSM14A	Pathway Commons Protein-Protein Interactions	1.0	null
ZFP91	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-329	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHCR24	Pathway Commons Protein-Protein Interactions	1.0	null
RBM3	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2E2	Pathway Commons Protein-Protein Interactions	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21417
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ulcerative Colitis_Peripheral blood mononuclear cell_GSE3365	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.63521
POLRMT	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7654-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9905_XRCC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.674706
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MTFMT	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11476310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50116
MPP2	Pathway Commons Protein-Protein Interactions	1.0	null
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993237
H2AFZ	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635607
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97421379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49954
CTNND1	Pathway Commons Protein-Protein Interactions	1.0	null
BD-48-ZT65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349911
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232515
PMC11880379-41467_2025_57480_MOESM3_ESM.xlsx-SOX9_RIME_Limma-Gene_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49905
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921824
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-75-FA82_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233324
3' -UTR-mediated translational regulation	Reactome Pathways 2014	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995573
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24687
XRCC6	MSigDB Cancer Gene Co-expression Modules	1.0	null
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994251
ZNF384	ENCODE Transcription Factor Targets	1.0	null
BRD-K95937143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08451
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11538
BRD-A61778798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41793
NEDD4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07047
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
Cytosolic ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Eukaryotic Translation Initiation	Reactome Pathways 2024	1.0	null
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29956
DD-30-SX80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28978
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04874
BL119 (ATR)	NURSA Protein Complexes	1.0	null
SNU5	CCLE Cell Line Gene CNV Profiles	1.0	1.47946
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51059
BRD-K77797840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0922
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05672
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPS26	Pathway Commons Protein-Protein Interactions	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211902
subiculum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02176
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSK3B_knockdown_202_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.48645
kidney	GTEx Tissue Gene Expression Profiles	1.0	0.888389
cellular localization	GO Biological Process Annotations 2015	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein localization to endoplasmic reticulum	GO Biological Process Annotations 2015	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337333
Cap-dependent Translation Initiation	Reactome Pathways 2024	1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267411
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82152
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05773
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2655
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.527558
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904694
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850009
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30956
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
TRABD2A	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2AJ	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SEC24B	Pathway Commons Protein-Protein Interactions	1.0	null
AP2B1	Pathway Commons Protein-Protein Interactions	1.0	null
RPRD2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56207
GPC4	Pathway Commons Protein-Protein Interactions	1.0	null
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203912
BRD-K66401298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66477
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890309
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62588
nuclear-transcribed mrna catabolic process, nonsense-mediated decay	GO Biological Process Annotations 2015	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cellular nitrogen compound catabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF541	Pathway Commons Protein-Protein Interactions	1.0	null
DYNC2H1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11491
hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47652
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352714
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.936536
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31213
Microvillus membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
GPR82	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00709101
rna catabolic process	GO Biological Process Annotations 2015	1.0	null
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.1041
MAP3K1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JF-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCTP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.986408
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
CDC40	Pathway Commons Protein-Protein Interactions	1.0	null
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834464
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29127
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54795
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ANLN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XV7Q-1526-SM-4BRWB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870689
BRD-K50942788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16088
MRPS35	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23021
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854509
DHX57	Pathway Commons Protein-Protein Interactions	1.0	null
RIMS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532978
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POP5	Pathway Commons Protein-Protein Interactions	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
WDFY3	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol_homo sapiens_gpl570_gse29881	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250953
PLEKHH1	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS18B	Pathway Commons Protein-Protein Interactions	1.0	null
TWIST1_01_253	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.5897
TBL2	Pathway Commons Protein-Protein Interactions	1.0	null
SDC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00440077
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_31_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895996
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48401
BRD-K73125678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11505
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mrna metabolic process	GO Biological Process Annotations 2015	1.0	null
EHMT2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-0008-SM-4DXT8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829945
KRT75	Pathway Commons Protein-Protein Interactions	1.0	null
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427559
BRD-K71251432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94741
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47841
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PARP1	Pathway Commons Protein-Protein Interactions	1.0	null
FAU	Pathway Commons Protein-Protein Interactions	1.0	null
EST1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21003
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25492
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPUSD2	Pathway Commons Protein-Protein Interactions	1.0	null
nt2d1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.887
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DRG1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MPG	Pathway Commons Protein-Protein Interactions	1.0	null
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITGAL	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826743
IMP3	Pathway Commons Protein-Protein Interactions	1.0	null
lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10023
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45708
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K83670234_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94992087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00665
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4582-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAMA1	CCLE Cell Line Gene CNV Profiles	1.0	1.48637
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70222
ACTL6A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12601
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
SCaBER cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.157
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931786
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CACNA1G	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01351858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52504
HOXC9	ChEA Transcription Factor Targets	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H2BF	Pathway Commons Protein-Protein Interactions	1.0	null
TFRC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524645
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45778
A2058_SKIN	CCLE Cell Line Proteomics	1.0	2.85455
PRKCDBP	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.8146
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08938
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32546
TALL-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.83298
JB-89-SI60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502122
PMC6428271-pone.0213813.s007.xlsx-LPS_anti-IL-10_significant_PPIs-node1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DBR1	Pathway Commons Protein-Protein Interactions	1.0	null
METTL17	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19403
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.51552
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
gemcitabine_homo sapiens_gpl96_gse6914	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50140147_CT-TAE684_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.57801
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.5659
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075626
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.265
artery	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43479153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22602
cellular nitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K97741413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5035
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22987
H3K79me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.48597
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65805
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
BRD-K12281552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24611
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMYD4	Pathway Commons Protein-Protein Interactions	1.0	null
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15493
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24192
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF462	Pathway Commons Protein-Protein Interactions	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.49116
DGKH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653192
NIPSNAP1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF747	Pathway Commons Protein-Protein Interactions	1.0	null
ACOT9	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3812
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.948696
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.946521
ZNF724P	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36428
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DKC1	Pathway Commons Protein-Protein Interactions	1.0	null
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_homo sapiens_gpl570_gse23610	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993247
BRD-K12683022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15822
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.79604
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881169
SDHB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
RBM48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21275
PABPC1	NURSA Protein-Protein Interactions	1.0	0.023805
SIX5	ENCODE Transcription Factor Targets	1.0	null
KEAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.7679
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85901675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65922
4270_KANSL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.500127
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21401
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.90288
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947459
DTYMK	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.78116
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267497
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20134
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.979339
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50009
RPL28	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46877890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01064
SRRM2	Pathway Commons Protein-Protein Interactions	1.0	null
ZFHX3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.68235
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56623
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DCUN1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727188
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EREG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530464
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.952323
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30542
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881338
SEC24C	Pathway Commons Protein-Protein Interactions	1.0	null
GTF3C5	Pathway Commons Protein-Protein Interactions	1.0	null
large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
RPA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PLA2G4A	Pathway Commons Protein-Protein Interactions	1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48467
TJP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2B	Pathway Commons Protein-Protein Interactions	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31211
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55302
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998521
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88K-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
LARP1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K70935154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16623
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
TUHR14TKB	CCLE Cell Line Gene CNV Profiles	1.0	1.75086
MXI1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95591068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34357
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06359
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1334_CCNL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.833854
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24977393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3826
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	Pathway Commons Protein-Protein Interactions	1.0	null
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18088
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25054
BRD-K81916372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35291
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A705-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF3A1	Pathway Commons Protein-Protein Interactions	1.0	null
CSNK1G2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406308
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553612
CDK5RAP2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3834
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29558
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPL27	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS17	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18737347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56259
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
10223_ZNF22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.533889
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5493_NCBP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45358
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25679
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
TUBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22416
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.297063
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18366
BRD-K68459574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04339
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30099
CBX3	Pathway Commons Protein-Protein Interactions	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.877406
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070863
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88794
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNAJC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13568
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
PPIP5K2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.952005
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
RBFOX2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A50837272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47043
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30973
ZNF302	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11297155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22519
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
DDX42	Pathway Commons Protein-Protein Interactions	1.0	null
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.786
BRD-K14359826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61574
SP2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cervical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.11117
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SUV39H2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840799
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.757
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23122
RPL11	Pathway Commons Protein-Protein Interactions	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19427
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.67336
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08172
HEXIM1	Pathway Commons Protein-Protein Interactions	1.0	null
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.861355
BRD-K57972271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27657
BRD-K78574327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07849
BRD-K37892442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76894
PeBoW complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
BRD-K02637850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0444
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.891807
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45729
SPI1	ENCODE Transcription Factor Targets	1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881302
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16015
MECP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09829
CBR3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10978
stratum pyramidale of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.84771
BRD-K87383650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25464
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968284
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EPHA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058182
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
SGPL1	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2AB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A09961470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20928
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22865
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TNP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495553
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85442
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4617
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAOV3_OVARY	CCLE Cell Line Proteomics	1.0	3.62371
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-00-ZO24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269835
Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07047
CALCOCO2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K86004174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35296
BL3961 (PES1)	NURSA Protein Complexes	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59764
Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZSCAN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00952
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32925057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08315
hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6716
HIST1H2BM	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_1176_KD_RUNX1_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
FMR1	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1064
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07895
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.06292
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PDHB	Pathway Commons Protein-Protein Interactions	1.0	null
TMEM160	Pathway Commons Protein-Protein Interactions	1.0	null
PRKCI	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K99727034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11342
GTEX-P4QS-1326-SM-3NMCD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855716
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TUBA1A	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76812105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96547
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tonsil	HPA Tissue Protein Expression Profiles	1.0	0.723381
BRD-K42363982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00837
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.137793
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60456
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4734
ACC3	BioGPS Cell Line Gene Expression Profiles	1.0	1.16238
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941068
PRKAG1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRRM1	Pathway Commons Protein-Protein Interactions	1.0	null
PRKAR1B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17513
POU2F2	ENCODE Transcription Factor Targets	1.0	null
Perturb_5976_KD_TRA2B_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.08833
SYNE1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71574401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34905
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54837058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13301
TUBB6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2166
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K21759602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03321
FOSL2	ENCODE Transcription Factor Targets	1.0	null
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.121
FAM98C	Pathway Commons Protein-Protein Interactions	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GLA	Pathway Commons Protein-Protein Interactions	1.0	null
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62885
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system development	Reactome Pathways 2024	1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.67878
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
cytosol	GO Cellular Component Annotations 2015	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15566
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
CACNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580261
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70987
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Signaling by ROBO receptors	Reactome Pathways 2024	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94382
DDX3Y	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527273
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
B4GALNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516778
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22147
cellular macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K44139682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34519
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
ZNF688	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47557
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474663
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	0.723381
CRCGN015_MCF10A_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29634
histone deacetylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.270434
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.88117
translational termination	GO Biological Process Annotations 2015	1.0	null
BRD-K91843292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13327
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
NFATC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00943037
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882736
mesoderm	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49777
POTEE	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SC-48847 (BRE)	NURSA Protein Complexes	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.871673
nb4	HPA Cell Line Gene Expression Profiles	1.0	0.870406
HLA-B	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BF-01B-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941581
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11931
chd-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.408309
H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COL1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00434104
BRD-K23728544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49156
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47469
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_707_KD_SETDB1_SRP116955	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05055
TSR2	Pathway Commons Protein-Protein Interactions	1.0	null
PSMC1	Pathway Commons Protein-Protein Interactions	1.0	null
CA-48-SW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308681
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987086
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
FERMT3	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2AC	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIPA1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567092
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69014
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987591
FRMPD4	Pathway Commons Protein-Protein Interactions	1.0	null
LARP4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07972
DPY30	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80945184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18485
BRD-K47980183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11617
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04081
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAV3	Pathway Commons Protein-Protein Interactions	1.0	null
MICU1	Pathway Commons Protein-Protein Interactions	1.0	null
1943_CTR9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.654139
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USP48	Pathway Commons Protein-Protein Interactions	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TPI1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
1334_CCNL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.573532
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1_KD_GDS3788_488_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K44856541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59895
BRD-K17303020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3978
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.504931
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.216
BUB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K72843176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33461
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.7483
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05122615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20193
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20898
PCI-6A	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.09695
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06919
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27942
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93508241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56705
BRD-K62147342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26063
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autoimmune disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
SDF4	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51966
SLC29A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661907
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SGOL1	Pathway Commons Protein-Protein Interactions	1.0	null
ITGAE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00370484
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
salivary gland	HPA Tissue Protein Expression Profiles	1.0	0.723381
SLC3A2	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF346	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.879168
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGPAT1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05626
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00698
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.221
7452_RPL26L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.13031
AFD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00921958
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38383
heterocycle biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85925
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45396
ZNF483	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRPA1	Pathway Commons Protein-Protein Interactions	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K54236126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03227
THAP1	ENCODE Transcription Factor Targets	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06379
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882305
6446_PLEKHJ1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.607205
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23116
CTCF_GM12801_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.947508
Rectum adenocarcinoma_READ_TCGA-DC-4745-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34615
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51022
BRD-K54028343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07571
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.64008
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06278
protein localization to membrane	GO Biological Process Annotations 2015	1.0	null
PHF5A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07774
BRD-K23366960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24408
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957283
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235748
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882896
PTRH2	Pathway Commons Protein-Protein Interactions	1.0	null
symbiosis, encompassing mutualism through parasitism	GO Biological Process Annotations 2015	1.0	null
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19943
BRD-K77273085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03457
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I4-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZC3H15	Pathway Commons Protein-Protein Interactions	1.0	null
EMG1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51444
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-CCRF-CEM_SCR_vs_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.933423
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15954
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1202
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826576
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRB7	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02071
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48565
ERI1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UA-39-TN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246097
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66687
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58206
FAM98A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25172
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6280_PHF12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.73072
NRD1	Pathway Commons Protein-Protein Interactions	1.0	null
NHP2L1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-3615-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF764	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91962
GSE160817_0_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11819
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1199
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.25336
GBAS	Pathway Commons Protein-Protein Interactions	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02181
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.10585
TARS2	Pathway Commons Protein-Protein Interactions	1.0	null
MTDH	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908109
POLG2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC59	Pathway Commons Protein-Protein Interactions	1.0	null
LARP4B	Pathway Commons Protein-Protein Interactions	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927333
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WDR77	Pathway Commons Protein-Protein Interactions	1.0	null
MRPL41	Pathway Commons Protein-Protein Interactions	1.0	null
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GNRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3302
ZNF263	ENCODE Transcription Factor Targets	1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61986
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1965
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64173
JMSU1_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	4.92216
BRD-K89820077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1971
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
viral transcription	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.216
imatinib_homo sapiens_gpl96_gds3042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K13761649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08558
A673	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55867
MIB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54931539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66052
BRD-K11674021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2324
BRD-K12531686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16489
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21304
Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274088
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4755
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autoimmune disease of gastrointestinal tract	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97367
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3513
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9621
HSPA4	Pathway Commons Protein-Protein Interactions	1.0	null
calfactant	CTD Gene-Chemical Interactions	1.0	null
DDX24	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial cloud	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
CDK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00345382
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44325
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10097
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830645
SAMD14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36506
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7463
GLIPR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522626
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8328-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418626
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45272
FIP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74754874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49592
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
interspecies interaction between organisms	GO Biological Process Annotations 2015	1.0	null
RPS4Y2	Pathway Commons Protein-Protein Interactions	1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06439119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48305
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52051
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.729797
GTF3C4	Pathway Commons Protein-Protein Interactions	1.0	null
UBA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRWD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48102350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40808
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06320746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65342
GSE108500_1_v_0_foxp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02196
ZNRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2765
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87727
HIST1H1A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TENC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XYKS-0926-SM-4BRVG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834508
KLF16	Pathway Commons Protein-Protein Interactions	1.0	null
ZMYM3	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03672
AAGAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72738
GABPA	ENCODE Transcription Factor Targets	1.0	null
15670303-Table1	GeneSigDB Published Gene Signatures	1.0	null
RPL7L1	Pathway Commons Protein-Protein Interactions	1.0	null
SLC22A23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628731
hek293	HPA Cell Line Gene Expression Profiles	1.0	1.02953
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.870909
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H2BN	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05001008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06885
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIAA0319	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.833805
XC-88-ZM66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.413774
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13746
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.450889
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27975
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7464
SEC11C	Pathway Commons Protein-Protein Interactions	1.0	null
rRNA processing in the nucleus and cytosol	Reactome Pathways 2024	1.0	null
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL7A	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41814083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07347
1334_CCNL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.08737
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21271
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434544
RNF2	ENCODE Transcription Factor Targets	1.0	null
LIG3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8447597__EV3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K92712225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45681
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.28
PUS1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838753
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01815
BRD-K73528610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38029
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2727-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520647
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0424
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.01954
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053801
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205565
BRD-K67478255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77287
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444846
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	2.27427
HIST1H3B	Pathway Commons Protein-Protein Interactions	1.0	null
KU-19-19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HIST1H1E	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K08829593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28313
u2-os cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.712959
BCL7A	Pathway Commons Protein-Protein Interactions	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67563379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20974
BRD-K69154646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01707
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MT-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
ETV6	Pathway Commons Protein-Protein Interactions	1.0	null
DDX28	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5891_KD_C5orf41_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.90487
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UQCRFS1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67666705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13539
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TNRC6B	Pathway Commons Protein-Protein Interactions	1.0	null
PYCRL	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232407
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888905
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LX-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7606-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23655
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43851
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-450	GDSC Cell Line Gene Expression Profiles	1.0	2.18009
SRSF10	Pathway Commons Protein-Protein Interactions	1.0	null
osteosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.578016
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98276754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64666
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869893
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.7176
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13702
translation	GO Biological Process Annotations 2025	1.0	null
ZNF274	Pathway Commons Protein-Protein Interactions	1.0	null
U2AF1	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882736
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8819
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RRP12	Pathway Commons Protein-Protein Interactions	1.0	null
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.981311
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NSMAF	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35822
BRD-K31747470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17524
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43738
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882305
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACTBL2	Pathway Commons Protein-Protein Interactions	1.0	null
KMRC2	CCLE Cell Line Gene CNV Profiles	1.0	1.37678
GSK3A_knockdown_201_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.98076
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234231
NARF	Pathway Commons Protein-Protein Interactions	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.7095
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPSF7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54067431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07309
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.78185
MIF	Pathway Commons Protein-Protein Interactions	1.0	null
RET (RET)	NURSA Protein Complexes	1.0	null
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K49681465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53422
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10512
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.14797
CMTM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0062064
GRK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522834
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8339
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
CTNNBIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540302
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14375
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01646
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09421
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.93128
organic cyclic compound catabolic process	GO Biological Process Annotations 2015	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metaphase_anaphase_telophase_15min_noscapine_release vs ctrl_HeLa (Human) [19691289]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XGQ4-1526-SM-4AT6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875611
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic translation	GO Biological Process Annotations 2023	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS4Y1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07161
PCBD1	Pathway Commons Protein-Protein Interactions	1.0	null
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
CDCA8	Pathway Commons Protein-Protein Interactions	1.0	null
DIRAS2	Pathway Commons Protein-Protein Interactions	1.0	null
LSM4	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23299
SIPA1L3	Pathway Commons Protein-Protein Interactions	1.0	null
EXOSC2	Pathway Commons Protein-Protein Interactions	1.0	null
Inflammatory bowel disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.121
CRNKL1	Pathway Commons Protein-Protein Interactions	1.0	null
UBAP2L	Pathway Commons Protein-Protein Interactions	1.0	null
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
CRO-AP3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DIS3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13895
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.263
CEBPB_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cerebellum	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.05999
RASAL3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12870_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203429_0_v_1_angptl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EIF3I	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPB41L1	Pathway Commons Protein-Protein Interactions	1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
STAT1	ENCODE Transcription Factor Targets	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90872016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21407
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
LSM14B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92344227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06337
BRD-K95485901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89884
NEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33297
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WIPF1	Pathway Commons Protein-Protein Interactions	1.0	null
NOC2L	Pathway Commons Protein-Protein Interactions	1.0	null
S0-EE-Y737_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371896
IRF1	ENCODE Transcription Factor Targets	1.0	null
ZBTB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19081
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453023
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CENPV	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.880329
EGLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7926
GTEX-PLZ5-0326-SM-3P614	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948441
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.9658
EHMT1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01847
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16515
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40981
QARS	Pathway Commons Protein-Protein Interactions	1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32654
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14523
BRD-K31013025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36519
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23023
leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.786
OTUD4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43981353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47036
KPNA3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38716
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0002
DYNC1LI1	Pathway Commons Protein-Protein Interactions	1.0	null
ulcerative colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.211261
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19328
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31425
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.457349
Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DOCK10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056371
SART1	Pathway Commons Protein-Protein Interactions	1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.871387
HDAC6	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872849
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
NIP7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22496
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19478
L13a-mediated translational silencing of Ceruloplasmin expression	Reactome Pathways 2024	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051597
localization	GO Biological Process Annotations 2015	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6353
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907651
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936649
TAF7_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.463013
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23271
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27692
ABCA9	Pathway Commons Protein-Protein Interactions	1.0	null
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8087
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.64453
BRD-K36289678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44559
PMC4496795-srep12063-s2.xls-STAT1_subnetwork-Gene_symbol_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
5146_MON1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.679963
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3538
Extrachromosomal DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
RPF2	Pathway Commons Protein-Protein Interactions	1.0	null
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR1A	Pathway Commons Protein-Protein Interactions	1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232414
MCM4	Pathway Commons Protein-Protein Interactions	1.0	null
HSPE1	Pathway Commons Protein-Protein Interactions	1.0	null
ERMAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00707316
SAMD9L	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42087
RPL26	Pathway Commons Protein-Protein Interactions	1.0	null
TIA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02599
NOC4L	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18735
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
translational initiation	GO Biological Process Annotations 2015	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATXN2L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35029
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6429
BRD-K97929312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48797
BRD-K20798215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68084
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
RTCA	Pathway Commons Protein-Protein Interactions	1.0	null
MAGT1	Pathway Commons Protein-Protein Interactions	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Selenoamino acid metabolism	Reactome Pathways 2024	1.0	null
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64745
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27013
protein targeting	GO Biological Process Annotations 2015	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27771
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.445486
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CKB	Pathway Commons Protein-Protein Interactions	1.0	null
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX2	Pathway Commons Protein-Protein Interactions	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AIMP2	Pathway Commons Protein-Protein Interactions	1.0	null
SQSTM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14359942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32141
CA-60-LK14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304416
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209807
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65185
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96638
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.78911
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.87289
HIST1H2BD	Pathway Commons Protein-Protein Interactions	1.0	null
ETV3	Pathway Commons Protein-Protein Interactions	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273366
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.72371
Primary immunodeficiency disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
SBDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545211
SAMD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03256
MSH6	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47304
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
CUL5	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CELF1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69932463_AZD-8055_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05737
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0847
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytosolic large ribosomal subunit	GO Cellular Component Annotations 2025	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PADI2	Pathway Commons Protein-Protein Interactions	1.0	null
CSTB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03606
BRD-K46561246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39499
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC-92-HS43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216959
XC-13-LW13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20204
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H1-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CWF19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01338
SLC5A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058191
Cellular responses to stress	Reactome Pathways 2024	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.905905
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.975294
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877897
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40804250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40451
SRP-dependent cotranslational protein targeting to membrane	Reactome Pathways 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT24	Pathway Commons Protein-Protein Interactions	1.0	null
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
lateral tuberal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.96603
MRGBP	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJC10	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01663
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01002
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4891
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A6UO-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24591
SEC24A	Pathway Commons Protein-Protein Interactions	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25844
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45092891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01042
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18264
HIST1H1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95854766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0196
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.623
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04063
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53481
BRD-K88590066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52781
CHD1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0835
POTEF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26273412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60409
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64268886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03594
BRD-K64640769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03487
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.302838
Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.997315
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ARG1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UTP11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490239
BRD-K56618252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58761
MRPS16	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS2	Pathway Commons Protein-Protein Interactions	1.0	null
PRKAA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78005
SUMO activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
NCAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620027
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939421
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GD-59-OG21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228396
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
ATG7	Pathway Commons Protein-Protein Interactions	1.0	null
TECR	Pathway Commons Protein-Protein Interactions	1.0	null
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
BL1576 (ESCO1)	NURSA Protein Complexes	1.0	null
FGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00698403
RBM14	Pathway Commons Protein-Protein Interactions	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412555
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SGOL2	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75330923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05361
ribosomal large subunit biogenesis	GO Biological Process Annotations 2025	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39361
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
translation	GO Biological Process Annotations 2023	1.0	null
Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IGSF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00770263
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8122
BRD-K50315405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42116
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
NOC3L	Pathway Commons Protein-Protein Interactions	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9098
MCM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.02
Eukaryotic translation initiation factor 2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.088
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59006776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17295
ALMS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692316
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056068
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38215
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.882735
MRPL12	Pathway Commons Protein-Protein Interactions	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04146
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ADD3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14397
BPTF	Pathway Commons Protein-Protein Interactions	1.0	null
Colitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
NR2F2	ENCODE Transcription Factor Targets	1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.601865
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71221
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTP hydrolysis and joining of the 60S ribosomal subunit	Reactome Pathways 2014	1.0	null
MAMDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07457
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84271
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4V-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.543307
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0573
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.980551
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62709
LUC7L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44415466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01307
BRD-K56161905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2051
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2242
GCT	GDSC Cell Line Gene Expression Profiles	1.0	1.52762
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RRM1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22832
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154577_6_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
CWC15	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K98941192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62373
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.893499
TNFRSF12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666511
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.900147
CRCGN010_HEPG2_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14355
GTF2B	ENCODE Transcription Factor Targets	1.0	null
FC-85-OX77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236483
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST3H3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19795
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
etoposide_homo sapiens_gpl10558_gse33990	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.31783
BL4508 (SMARCAD1)	NURSA Protein Complexes	1.0	null
SW 982	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22226
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDC5L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56738235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01941
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15954
SNRPB	Pathway Commons Protein-Protein Interactions	1.0	null
RPL27A	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880965
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.86355
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00970182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97901
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97097
RBM26	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMARCA5	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.830737
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4099-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-70-GR31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270633
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19626
SLC25A12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559555
BRD-K80807286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35212
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74292
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97888
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44329
NSUN4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6428271-pone.0213813.s007.xlsx-LPS_anti-IL-10_significant_PPIs-node2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H2BFS	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71578
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371703
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.905733
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206175
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPR158	Pathway Commons Protein-Protein Interactions	1.0	null
PRH2	Pathway Commons Protein-Protein Interactions	1.0	null
FASTKD1	Pathway Commons Protein-Protein Interactions	1.0	null
skeletal muscle cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.314046
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
STRBP	Pathway Commons Protein-Protein Interactions	1.0	null
GJA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502019
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.887422
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9769
CDC42EP1	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PDXK	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2748
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0115312
EB-44-GM58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225916
RAB3GAP2	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.1831
PABPC4	Pathway Commons Protein-Protein Interactions	1.0	null
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A52377240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18067
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.953864
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-A52193669_2816_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K37131263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59293
OBSCN	Pathway Commons Protein-Protein Interactions	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287644
SND1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
COA6	Pathway Commons Protein-Protein Interactions	1.0	null
ALOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00426971
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A68009927_daunorubicin_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
large ribosomal subunit	GO Cellular Component Annotations 2023	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.884094
NOP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71268
RPL7	Pathway Commons Protein-Protein Interactions	1.0	null
SEC11A	Pathway Commons Protein-Protein Interactions	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054057
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77O-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43224
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
API5	Pathway Commons Protein-Protein Interactions	1.0	null
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
ADAMTSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497635
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCoV-EMC2012_7Hour_23631916_GSE45042	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.25948
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363045
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.75735
TRA2A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22459
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.42005
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
smad protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.171937
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38656
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
BRD-A59009217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29748
AC-55-GO91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213579
PTBP3	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-AH-6544-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RALGAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04257
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34248
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56753
CF-97-KZ12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218569
Ewing's sarcoma_Renal Tissue_GSE1822	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.98579
RALY	Pathway Commons Protein-Protein Interactions	1.0	null
MAP3K10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578127
SK-LU-1	GDSC Cell Line Gene Expression Profiles	1.0	1.42433
PSMC4	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCAPD3	Pathway Commons Protein-Protein Interactions	1.0	null
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.889141
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5-Ethynyluracil	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6908
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69519
kidney	HPA Tissue Gene Expression Profiles	1.0	1.58551
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061576
FGFBP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60830482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09108
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6374
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
NICN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593749
MRPS34	Pathway Commons Protein-Protein Interactions	1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04855
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059564
RPS12	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SPCS2	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09669
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mcf7	HPA Cell Line Gene Expression Profiles	1.0	1.56937
BRD-A84867566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1759
BRD-K50604515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48195
FCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521786
Metabolism of RNA	Reactome Pathways 2024	1.0	null
ATP5H	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL5054 (POLE3)	NURSA Protein Complexes	1.0	null
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K53095870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14562
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
establishment of protein localization to endoplasmic reticulum	GO Biological Process Annotations 2015	1.0	null
C2orf49	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74224
BRD-K41272069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29735
pridinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29343
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.98688
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LV-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09597
NRF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26661
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7307
3942_HS3ST3A1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.645057
BRD-K98938484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00077
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08011
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982857
organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33006
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.461677
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61462
TARDBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18717
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33473
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363998
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.333
NF-21-HQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301003
SHANK2	Pathway Commons Protein-Protein Interactions	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL2263 (DOCK9)	NURSA Protein Complexes	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10675
BRD-K39715006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12759
KCNQ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22023
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.653088
MYBL2	ENCODE Transcription Factor Targets	1.0	null
CLCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060759
KHDRBS1	Pathway Commons Protein-Protein Interactions	1.0	null
RPS15	Pathway Commons Protein-Protein Interactions	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T2-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91615044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16657
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02295
BRD-K78493876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50096
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36777
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KAT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28795
CYTH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00377289
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44743
intracellular organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56976
GMPPA	Pathway Commons Protein-Protein Interactions	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
USP17L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78783
TAF2	Pathway Commons Protein-Protein Interactions	1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.1362
NB-17-SQ59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299311
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCAR1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8411-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ntera2	HPA Cell Line Gene Expression Profiles	-1.0	-0.846287
SMARCB1	Pathway Commons Protein-Protein Interactions	1.0	null
basolateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58502
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08923
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DEF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00734365
H2AFJ	Pathway Commons Protein-Protein Interactions	1.0	null
ACACA	Pathway Commons Protein-Protein Interactions	1.0	null
BL2255 (PRKRIR)	NURSA Protein Complexes	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22701
biological_process	GO Biological Process Annotations 2015	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998521
large ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963325
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830562
BRD-K43456755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15794
TBC1D15	Pathway Commons Protein-Protein Interactions	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.537896
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925018
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24621
EIF3L	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20H-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRRC2A	Pathway Commons Protein-Protein Interactions	1.0	null
OMC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.14392
GTEX-P4QS-1826-SM-2S1NI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867442
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.096
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31029
EIF4G1	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01164
DDRGK1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PCMT1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54852
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.852381
BRD-K70791360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30096
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49895
LY9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055589
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3180-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863837
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.916443
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58043
CRCGN008_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81225
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914113
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632594
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0228
SMARCA2	Pathway Commons Protein-Protein Interactions	1.0	null
POFUT2	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8384902-mmc6.xlsx-DEG_ASCL1_3TF_shared-GeneSymbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
SRPRB	Pathway Commons Protein-Protein Interactions	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311982
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K55853030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75093
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNA binding	GO Molecular Function Annotations 2023	1.0	null
ZBTB18	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97958
DHX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07208
RPS6KB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00704159
BRD-K13044705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00094
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-6.23417
DENND3	Pathway Commons Protein-Protein Interactions	1.0	null
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509539
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33851
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30596
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBC1D4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00384652
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
HIST1H2AH	Pathway Commons Protein-Protein Interactions	1.0	null
ACTC1	Pathway Commons Protein-Protein Interactions	1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240151
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859867
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59295
BRD-K10459972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3373
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08123
RBM8A	Pathway Commons Protein-Protein Interactions	1.0	null
CCT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42327
RAB11FIP5	Pathway Commons Protein-Protein Interactions	1.0	null
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3585
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20563
NCIH1563	CCLE Cell Line Gene CNV Profiles	1.0	1.45119
BRD-K01266518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56173
BL2462 (DDX5)	NURSA Protein Complexes	1.0	null
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM56	Pathway Commons Protein-Protein Interactions	1.0	null
POLR3A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39867
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	0.904437
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4204
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909599
BRD-K91225366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68405
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75243062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7583
SRPR	Pathway Commons Protein-Protein Interactions	1.0	null
EIF2B4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92349794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62458
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18128277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56696
DDX54	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849975
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046356
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOP16	Pathway Commons Protein-Protein Interactions	1.0	null
OVCAR8	BioGPS Cell Line Gene Expression Profiles	1.0	1.97245
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.7473
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
5146_MON1A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.02247
SF3B5	Pathway Commons Protein-Protein Interactions	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.471366
MBD4	ENCODE Transcription Factor Targets	1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.032
embryonic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228764
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09898
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.876953
organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05208
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
17638893-SuppTable7	GeneSigDB Published Gene Signatures	1.0	null
RPP30	Pathway Commons Protein-Protein Interactions	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NXF1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61024
ZBTB44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01822
ribonucleoprotein complex	GO Cellular Component Annotations 2015	1.0	null
ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.433801
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.404975
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48043
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983544
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23512
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863971
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056253
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456961
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13514097_S1120_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-359_common_elements_in_HIF1_peaks_and_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC6	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04612
HIST1H2BH	Pathway Commons Protein-Protein Interactions	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052937
cellular protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99470595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38117
BRD-A12894472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27367
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560678
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XRN2	Pathway Commons Protein-Protein Interactions	1.0	null
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265935
CMTM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00761117
BRD-K48835953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03629
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.99417
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.39965
HCC1482	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.976689
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08765
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49268
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
RPL36AL	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF689	Pathway Commons Protein-Protein Interactions	1.0	null
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.968475
SSR4	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348305
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03709
GTF3C1	Pathway Commons Protein-Protein Interactions	1.0	null
HDLBP	Pathway Commons Protein-Protein Interactions	1.0	null
KB-05-VJ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210447
BEN	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3467
viral process	GO Biological Process Annotations 2015	1.0	null
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
STRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9279
PMC8563805-41598_2021_858_MOESM2_ESM.xlsx-Supplementary_Info_8-Gene_List_8_The_list_of_human_orthologs_of_the_downregulated_fly_DEGs_identified_from_PARIS_C571A_mutant_vs_PARIS_wild_type_comparison_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92212152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34575
GABP	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46820725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27799
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03765
ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.08476
RNMT	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45172622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33212
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01259
PPP1R1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633919
LIN28B	Pathway Commons Protein-Protein Interactions	1.0	null
FYTTD1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LIMS1	Pathway Commons Protein-Protein Interactions	1.0	null
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7291
Appendicitis_Appendix_GSE9579	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.38762
BRD-K95871937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37705
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78907873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00452
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52392
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872112
ZNF703	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52481
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS15	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:I18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43241
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934182
RPL37	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.40815
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053368
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43692
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459445
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.59501
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209893
NCIH2342	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78469
CDK8_knockdown_88_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.58851
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46069
CRCGN012_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01979
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284515
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OGG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01243
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TJP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10784
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.852595
HOXB5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81982648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34343
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7283
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14302
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Translation preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.018
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881338
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03026
BL2882 (CHEK2)	NURSA Protein Complexes	1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.884094
MAGOH	Pathway Commons Protein-Protein Interactions	1.0	null
Translation	Reactome Pathways 2014	1.0	null
EP300_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAP3K14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580698
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941581
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A78R-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DALRD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00880544
FN1	Pathway Commons Protein-Protein Interactions	1.0	null
NOP14	Pathway Commons Protein-Protein Interactions	1.0	null
Nanotubes, Carbon	CTD Gene-Chemical Interactions	1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21325
TMPRSS11A	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00196
CRCGN009_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18266
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36887
GPR84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608812
PWP1	Pathway Commons Protein-Protein Interactions	1.0	null
CDV3	Pathway Commons Protein-Protein Interactions	1.0	null
NF-21-HQ00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308663
PDIA6	Pathway Commons Protein-Protein Interactions	1.0	null
RANBP6	Pathway Commons Protein-Protein Interactions	1.0	null
PLOD1	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K49721311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27965
AP1S2	ChEA Transcription Factor Targets	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
RBM22	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.76873
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.55685
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.939799
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74041
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00106
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.84823
LCN12	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46701848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7609
Response of EIF2AK4 (GCN2) to amino acid deficiency	Reactome Pathways 2024	1.0	null
ADAM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88741
DNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0861
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.447799
C2orf16	Pathway Commons Protein-Protein Interactions	1.0	null
membrane organization	GO Biological Process Annotations 2015	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0549
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19864
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88179
ribonucleoprotein complex biogenesis	GO Biological Process Annotations 2025	1.0	null
NOP56	Pathway Commons Protein-Protein Interactions	1.0	null
CHAMP1	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.10223
ZFR	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321417
POGZ	Pathway Commons Protein-Protein Interactions	1.0	null
PFDN2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11693
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30735
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EXOSC10	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01727
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64645
UTP23	Pathway Commons Protein-Protein Interactions	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600187
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDF	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139592
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.401304
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33651
DRAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0086413
BRD-K62213484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06294
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K94516254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14596
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.567731
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29401
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	Pathway Commons Protein-Protein Interactions	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCKDHA	Pathway Commons Protein-Protein Interactions	1.0	null
MZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06589
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13241
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14831
HIST2H3A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	2.74196
BRD-K79433629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07981
BRD-K47724892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07922
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23743
PPP1R10	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45235
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07396820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20785
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.831047
EPC1	Pathway Commons Protein-Protein Interactions	1.0	null
RAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00943627
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K35587518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73747
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.53017
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287447
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACCMESO1	CCLE Cell Line Gene CNV Profiles	1.0	1.37219
CRCGN015_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07438
establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
6861_PSMC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.559794
BRD-K93339508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13197
intracellular protein transport	GO Biological Process Annotations 2015	1.0	null
BRD-K30661365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18724
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7406
skin	GTEx Tissue Gene Expression Profiles	1.0	1.22178
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.893349
POLE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62631
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06077
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.627533
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504161
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2608
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04146
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
CAND1	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
7452_RPL26L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.913985
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NOM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67014046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91467
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.08507
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRPF31	Pathway Commons Protein-Protein Interactions	1.0	null
VPS13B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699688
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
Eukaryotic Translation Termination	Reactome Pathways 2014	1.0	null
CTPS1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27931
BRD-K30558628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22369
IL17RE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006137
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56121
CUEDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659409
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965678
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.929261
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K06152379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62458
CSTF2	Pathway Commons Protein-Protein Interactions	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09799
JAK1_activemutant_61_GSE18239	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.66094
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hela cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.584422
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.96008
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34948
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998521
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47075
hsa-miR-421	MiRTarBase microRNA Targets	1.0	null
hnf1b_16297991_hek293_embryonic_gof_mouse_gpl96_gds1499	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.125997
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928786
Metabolism	Reactome Pathways 2024	1.0	null
KG1	CCLE Cell Line Gene CNV Profiles	1.0	1.5451
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56025
vascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YTHDF2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ARFGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
CSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
KRT6C	Pathway Commons Protein-Protein Interactions	1.0	null
germ layer	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29588
ABCA1	Pathway Commons Protein-Protein Interactions	1.0	null
BCLAF1	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77177732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22395
SW900	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70923
FOS	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01369
CKM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733542
SV2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547327
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.121
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15425
POLDIP3	Pathway Commons Protein-Protein Interactions	1.0	null
RCBTB1	Pathway Commons Protein-Protein Interactions	1.0	null
PDS5B	Pathway Commons Protein-Protein Interactions	1.0	null
CSDE1	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214614
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613201
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54357
EZH2	ENCODE Transcription Factor Targets	1.0	null
LE-80-QM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.703693
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29982
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.74507
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.121
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93718
RBM10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5084
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52922
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30275
BRD-K83115645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80139
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012829
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7229
GSE217541,GSE217543_3_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50689779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02992
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840146
protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAP3K6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495708
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K83988098_S1142_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF227	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4599
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99728124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19321
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15754
CEBPD	ENCODE Transcription Factor Targets	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.167452
JUN	ENCODE Transcription Factor Targets	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04084
EML4	Pathway Commons Protein-Protein Interactions	1.0	null
ribonucleoprotein complex biogenesis	GO Biological Process Annotations 2023	1.0	null
OCUB-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51033
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0258
POLR1C	Pathway Commons Protein-Protein Interactions	1.0	null
ZFP82	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31870622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08398
ZNF280D	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08034
LYZ	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04408214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1687
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26723
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2543
BRD-K40894545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22862
PMC6428271-pone.0213813.s007.xlsx-LPS_significant_GOs-name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931187
BRIX1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38980456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91458
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsomedial hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.871506
PRR5L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00837381
NCOR1	Pathway Commons Protein-Protein Interactions	1.0	null
Viral mRNA Translation	Reactome Pathways 2024	1.0	null
cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IL17F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51792
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FAF2	Pathway Commons Protein-Protein Interactions	1.0	null
RPS21	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25266
BRD-K88941096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41226
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF106	Pathway Commons Protein-Protein Interactions	1.0	null
MAGOHB	Pathway Commons Protein-Protein Interactions	1.0	null
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.28
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11624
KIF2A	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aromatic compound catabolic process	GO Biological Process Annotations 2015	1.0	null
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
NOP9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4685
GTEX-PLZ4-1326-SM-2S1O7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956409
RCN2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD74	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00736613
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75521
ING4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512647
CTCF	Pathway Commons Protein-Protein Interactions	1.0	null
MARCKSL1	Pathway Commons Protein-Protein Interactions	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208001
intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048875
POLR2B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10571700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17203
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.89266
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04049
RIMS2	Pathway Commons Protein-Protein Interactions	1.0	null
DUS3L	Pathway Commons Protein-Protein Interactions	1.0	null
17683518-193GeneTable	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48098
PHOSPHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59693
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TNR	Pathway Commons Protein-Protein Interactions	1.0	null
Cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.005
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PPP1CC	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K16551475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34374
TOE1	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1317
fallopiantube_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.882416
RUFY4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00508357
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47409867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46945
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACACB	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05304
EIF3K	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79347397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32497
CAMSAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01423
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BL3121 (SMEK1)	NURSA Protein Complexes	1.0	null
BRD-K50477983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44191
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235017_1_v_0_uba52_human	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20113
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00814
metaphase_anaphase_telophase_60min_noscapine_release vs ctrl_HeLa (Human) [19691289]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD50	Pathway Commons Protein-Protein Interactions	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11969
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.515167
MRPL14	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00429326
GUF1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.858022
Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PECR	Pathway Commons Protein-Protein Interactions	1.0	null
PDGFRA_knockdown_117_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.68087
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957313
SCAF1	Pathway Commons Protein-Protein Interactions	1.0	null
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200195
HSF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063525
BRD-K68953461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28014
3506_GPR108_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.61711
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057141
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913387
MRPS28	Pathway Commons Protein-Protein Interactions	1.0	null
Infectious disease	Reactome Pathways 2024	1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242641
BRD-K47049026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08852
rectum	HPA Tissue Protein Expression Profiles	1.0	0.723381
Parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.092
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPATS2L	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Coronavirus disease - COVID-19	KEGG Pathways 2026	1.0	null
ADAMTS20	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10931
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.945
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.329461
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838607
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09373
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
WWTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476847
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01221
nurd complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.409869
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMF1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN011_HEPG2_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0043
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4069
KCNG3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K79020643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2317
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-116-ESX1_ESX1	Rummagene Transcription Factor Associations 2026	1.0	null
transcriptional repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.181823
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048629
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30471
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10097
BRD-K94082609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48598
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H522	GDSC Cell Line Gene Expression Profiles	-1.0	-1.79957
ZNF568	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23271
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HKDC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K99978187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4864
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03916755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10969
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58242935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52826
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13027
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.73272
EWSR1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF773	Pathway Commons Protein-Protein Interactions	1.0	null
DACH1-20351289-MDA-MB-231-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CHAF1B	Pathway Commons Protein-Protein Interactions	1.0	null
rna metabolic process	GO Biological Process Annotations 2015	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCBL2	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917877
lung	HPA Tissue Protein Expression Profiles	-1.0	-1.23113
translational elongation	GO Biological Process Annotations 2015	1.0	null
RARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.018
ERH	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.30977
SETX	Pathway Commons Protein-Protein Interactions	1.0	null
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46714
polysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.405193
Lung squamous cell carcinoma_LUSC_TCGA-39-5019-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854893
BRD-K13551202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08249
GSE165548_2_v_8_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SRSF9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11781871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25901
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89198
ESYT2	Pathway Commons Protein-Protein Interactions	1.0	null
SRSF6	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2BB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CLEC11A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K19009595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08292
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27135
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62708
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04073
BRD-K66823946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07313
CRCGN015_MCF10A_48H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37653
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.66437
Cellular responses to stimuli	Reactome Pathways 2024	1.0	null
4281_KAT8_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.634402
PMC8563805-41598_2021_858_MOESM2_ESM.xlsx-Supplementary_Info_6-Gene_List_6_The_list_of_human_orthologs_of_the_downregulated_fly_DEGs_identified_from_TRAP_control_vs_PARIS_wild_type_comparison_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMA3	Pathway Commons Protein-Protein Interactions	1.0	null
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871177
CNIH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00794189
KIAA2026	Pathway Commons Protein-Protein Interactions	1.0	null
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00365
SUV39H1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSTP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00465049
7403_RNMT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31815
ZNF569	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A75409952_wortmannin_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03654379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05358
BRD-K48029682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27091
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3711
BRD-K73830970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93506
BRD-K11258719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11911
WBP2	Pathway Commons Protein-Protein Interactions	1.0	null
DDOST	Pathway Commons Protein-Protein Interactions	1.0	null
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02625776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6033
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
FTSJ3	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.575178
PARK2	Pathway Commons Protein-Protein Interactions	1.0	null
WDR12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0088483
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A92490200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.448
E2F6	ENCODE Transcription Factor Targets	1.0	null
PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051484
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30745
DF-95-CY55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216554
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28661
SUPT5H	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST2H2BF	Pathway Commons Protein-Protein Interactions	1.0	null
CALD1	Pathway Commons Protein-Protein Interactions	1.0	null
LMCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557902
BRD-K51320582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42822
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96417480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0251
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04231
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975727
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2499
MATN4	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCCC2	Pathway Commons Protein-Protein Interactions	1.0	null
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.525277
MAU2	Pathway Commons Protein-Protein Interactions	1.0	null
nuclear transcriptional repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.124547
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDX2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15841
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48096
FLI1	ChEA Transcription Factor Targets	1.0	null
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890849
EFO-21	GDSC Cell Line Gene Expression Profiles	1.0	1.48497
RBBP5	ENCODE Transcription Factor Targets	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05181466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22517
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Reactome Pathways 2024	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972315
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04892
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828128
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-A44990218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11611
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71976
MAP1A	Pathway Commons Protein-Protein Interactions	1.0	null
IGF2BP3	Pathway Commons Protein-Protein Interactions	1.0	null
BL2014 (AGAP3)	NURSA Protein Complexes	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31805
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885137
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0731
DENND6B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K66408914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5093
BRD-K43684831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18837
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892125
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409996
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K47983010_BX-795_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PHF20	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7197
LAD1	Pathway Commons Protein-Protein Interactions	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.99689
BRD-K00667983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55535
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879459
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JS-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37045
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04899
ASF1A	Pathway Commons Protein-Protein Interactions	1.0	null
ENO2	Pathway Commons Protein-Protein Interactions	1.0	null
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MAP3K5	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WDR6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60805
EP400	Pathway Commons Protein-Protein Interactions	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.964102
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF324B	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.863527
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MMP15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526318
Perturb_16502_KD_ASCL1_SRP325888	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35954
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215166
ZC3H14	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26291134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00555
CALR	Pathway Commons Protein-Protein Interactions	1.0	null
DHRS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619338
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251567
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36175
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFC2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36777
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
NOA1	Pathway Commons Protein-Protein Interactions	1.0	null
EEF1E1	Pathway Commons Protein-Protein Interactions	1.0	null
CENPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20034
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38303
HSPA6	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47456612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90807
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.609371
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
MICU2	Pathway Commons Protein-Protein Interactions	1.0	null
WBSCR22	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4325
Prostate	GTEx Tissue Gene Expression Profiles 2023	1.0	3.0343
BRD-K01754917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96472
GAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00342353
ANKRD34B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01096
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47941
MPHOSPH10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24369860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36599
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.458
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49421
BRD-K53127464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23441
Nrf-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_15535_KD_Ash1l_SRP366889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.40282
gallbladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.848579
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258411
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50077
TE10_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.53402
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16101
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.55308
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29558
DNAH8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05112
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33792
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050811
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70092
HOS	GDSC Cell Line Gene Expression Profiles	1.0	1.6575
PRPF4B	Pathway Commons Protein-Protein Interactions	1.0	null
HLA-DQA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00868063
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.4423
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.83712
BRD-K46322281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03861
ZNF649	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258036
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HB-75-KT12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301112
Ribosomal protein L24/L26, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
ESYT1	Pathway Commons Protein-Protein Interactions	1.0	null
FTC238	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36748
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.884604
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-A06149038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11589
DHRS2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93469
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0401
CA-16-ZL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202391
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-362-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
UTP14A	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892028
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10035
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07987
STAU1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
IGSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718017
LUDLU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47838
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50115
BRD-K70533557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04116
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4426-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18263
BRD-K69073616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62776
MAST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99585
MDAMB436_BREAST	CCLE Cell Line Proteomics	1.0	2.21728
HNRNPUL2	Pathway Commons Protein-Protein Interactions	1.0	null
NAT10	Pathway Commons Protein-Protein Interactions	1.0	null
TAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05046
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-0.992119
DYNLRB1	Pathway Commons Protein-Protein Interactions	1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9555
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
GHRHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598279
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERP44	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900183
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00979
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8385
BRD-K95653016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61818
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
MAATS1	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1386
BRD-K15099225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31675
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.507
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864694
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972285
U251	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.44822
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19355
ETS1	ENCODE Transcription Factor Targets	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279546
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44023
CREG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574384
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17534
TBC1D22B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00241
PCCA	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02548315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5467
AUH	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18801549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78016
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52978625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19765
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K17140735_-666_SW948_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DDB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31546068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97474
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRAK4_knockout_41_GSE12124	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.59905
BRD-K35935439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27769
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K49656278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05338
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.23113
Trachea	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03549
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBM15	Pathway Commons Protein-Protein Interactions	1.0	null
Cellular response to starvation	Reactome Pathways 2024	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.938135
IL1RAPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00746939
Peptide chain elongation	Reactome Pathways 2014	1.0	null
DSP	Pathway Commons Protein-Protein Interactions	1.0	null
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.851693
ZNF460	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K53335788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28809
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K53647637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76333
Ribosomal protein L2 domain 2	InterPro Predicted Protein Domain Annotations	1.0	null
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9333
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865737
SUCLG1	Pathway Commons Protein-Protein Interactions	1.0	null
SBNO2	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPI-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.832
Lung transplant rejection_Lung Tissue_GSE2018	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.50277
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30727
nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC6428271-pone.0213813.s007.xlsx-LPS_anti-IL-10_significant_GOs-name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17355
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70352
RPL15	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87779720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07041
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882305
organelle part	GO Cellular Component Annotations 2015	1.0	null
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.548118
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62107
CDC42	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556688
DACT1	Pathway Commons Protein-Protein Interactions	1.0	null
PTPLAD1	Pathway Commons Protein-Protein Interactions	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28893
FOSL2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	0.885147
BRD-K71415389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3346
BRD-A75409952_wortmannin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03476091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96217
Influenza Infection	Reactome Pathways 2024	1.0	null
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS9	Pathway Commons Protein-Protein Interactions	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.09656
BRD-K25649596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54055
BRD-K58248556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68598
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226269
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
pure red-cell aplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.921323
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CORL51	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51752
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96164740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71314
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G3BP1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNFRSF10D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611069
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64571
PSMB1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08718
RBFA	Pathway Commons Protein-Protein Interactions	1.0	null
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04196669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25571
DACH1-20351289-CHIP-SEQ-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14669
Formation of a pool of free 40S subunits	Reactome Pathways 2024	1.0	null
BRD-K32451879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10438
ZZEF1	Pathway Commons Protein-Protein Interactions	1.0	null
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTPN7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680174
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF1AX	Pathway Commons Protein-Protein Interactions	1.0	null
t-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.66102
SLC16A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00442696
G3BP2	Pathway Commons Protein-Protein Interactions	1.0	null
CBX5	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8040_KO_SHMT2_SRP390421	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.5229
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095712
EEF1D	Pathway Commons Protein-Protein Interactions	1.0	null
LYST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568426
MMP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56961
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18369
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.91387
AIMP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K94378105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27787
BRD-K29143088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80679
GTEX-S3XE-1726-SM-3K2AM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992921
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular protein localization	GO Biological Process Annotations 2015	1.0	null
GTPBP4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.39555
EPB41	Pathway Commons Protein-Protein Interactions	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RB-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX7	Pathway Commons Protein-Protein Interactions	1.0	null
viral life cycle	GO Biological Process Annotations 2015	1.0	null
PMC5504347-ncomms16056-s4.csv--Supplementary_Data_3_Transcript_abundance_of_ZNF598_ribosomal_proteins_and_genes_involved_in_the_RQC_pathway_ZNF598	Rummagene Transcription Factor Associations 2026	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.216
BRD-K43051162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30492
ZCCHC3	Pathway Commons Protein-Protein Interactions	1.0	null
SPCS1	Pathway Commons Protein-Protein Interactions	1.0	null
L13a-mediated translational silencing of Ceruloplasmin expression	Reactome Pathways 2014	1.0	null
CSNK2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17827
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE231891_5_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PRSS23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00441834
EXOSC4	Pathway Commons Protein-Protein Interactions	1.0	null
MAP3K7	Pathway Commons Protein-Protein Interactions	1.0	null
LOUCY	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02561
EXOSC9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ2-0226-SM-4DM6V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826829
Translation protein SH3-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.786
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.703381
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15493
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.351485
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29665
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885402
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TENM2	Pathway Commons Protein-Protein Interactions	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40552
PBX3	ENCODE Transcription Factor Targets	1.0	null
ETV7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101445
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.923095
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
RPL13AP3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90887068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56504
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13489
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41849
UBTF	Pathway Commons Protein-Protein Interactions	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06235
FZD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558047
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.723381
SMARCA4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K14653235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19724
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326593
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871006
SKNFI	CCLE Cell Line Gene CNV Profiles	-1.0	-2.54198
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALPK3	Pathway Commons Protein-Protein Interactions	1.0	null
SIRPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673363
TAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10156
TRMT2A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPL22	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sirolimus_homo sapiens_gpl96_gds2494	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HAT1	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPC	Pathway Commons Protein-Protein Interactions	1.0	null
CSF1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996988
IL27RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503731
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46798
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RECQL	Pathway Commons Protein-Protein Interactions	1.0	null
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9834_KO_miR31_SRP354225	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KIF12	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08046
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMRC20_KIDNEY	CCLE Cell Line Proteomics	1.0	8.6028
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43469
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0577
RPS15A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ARHGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM98B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K69569958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27484
HIST1H2AA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K30269093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1138
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213471
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
PKMYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03328
CWC22	Pathway Commons Protein-Protein Interactions	1.0	null
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1712
CCDC88A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10234
BRD-K30117087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19845
3011_FBXO28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.539056
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7449
BL469 (AURKA)	NURSA Protein Complexes	1.0	null
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36782
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06915
BRD-K92544320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17517
ELK1-19687146-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ribosome biogenesis	GO Biological Process Annotations 2025	1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30636
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86595
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04003
MDA-MB-157	GDSC Cell Line Gene Expression Profiles	1.0	3.00195
PRKRA	Pathway Commons Protein-Protein Interactions	1.0	null
PTPRH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454093
BRD-K41548770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03432
NCIH1436	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14195
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8662
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.5748
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HARS2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987696
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19975
GSE178714_3_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19504
CYP2U1	Pathway Commons Protein-Protein Interactions	1.0	null
DHX37	Pathway Commons Protein-Protein Interactions	1.0	null
RPL10A	Pathway Commons Protein-Protein Interactions	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.607659
vitamin c_homo sapiens_gpl6884_gse16590	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SB-29-ZH97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270417
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LAMA5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K02708799_GSK-1059615_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-66-UB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492382
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV5-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535818
Overexertion_Leukocyte_GSE3606	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.85637
PLOD2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
connecting stalk	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
endometrium_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.880546
THBS1	Pathway Commons Protein-Protein Interactions	1.0	null
Neural stem cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32038
MOB3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18259
BRD-K95875837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09584
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.926718
BRD-U29336476_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXC2	Pathway Commons Protein-Protein Interactions	1.0	null
MUC5AC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CE-18-AP85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330154
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478619
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.231448
SNW1	Pathway Commons Protein-Protein Interactions	1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059363
GTEX-Q2AI-1726-SM-2S1PZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940718
PSG8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00751847
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABRA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A75409952_wortmannin_HEC108_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44812
Perturb_1182_KD_RUNX1_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.7483
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.656841
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08255
translation	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36355
single-organism cellular localization	GO Biological Process Annotations 2015	1.0	null
BRD-K70735803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07134
CHTOP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K08174111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98432
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STRAP	Pathway Commons Protein-Protein Interactions	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K66254772_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YAF2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POP1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL32	Pathway Commons Protein-Protein Interactions	1.0	null
RPL15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00765016
BRD-K79299080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09315
cytoplasmic translation	GO Biological Process Annotations 2025	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STK32A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587508
RAG1	Pathway Commons Protein-Protein Interactions	1.0	null
U2SURP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95806
TOX4	Pathway Commons Protein-Protein Interactions	1.0	null
WIZ	Pathway Commons Protein-Protein Interactions	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.6145
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUCLG2	Pathway Commons Protein-Protein Interactions	1.0	null
LLGL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K94205659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1296
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFATC2IP	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H1FX	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A53L-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00777544
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23626
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZBTB33_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-944	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.06882
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994314
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65468
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25214
USF2	ENCODE Transcription Factor Targets	1.0	null
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
8420_SRPK2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.728582
ZC3HAV1L	Pathway Commons Protein-Protein Interactions	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.26312
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cytosolic large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06914
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18738
PNPLA6	Pathway Commons Protein-Protein Interactions	1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.849
WIBG	Pathway Commons Protein-Protein Interactions	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64173
BRD-K34414758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19571
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.23113
THNSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643477
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MS4A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00775366
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95953
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL36A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14520048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18352
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293674
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
RFC4	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.837001
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.07118
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M8-01A-21R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885117
BRD-K05135707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47931
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
CE-15-YU05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213345
H3F3A	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09315
DDX39A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K06219419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9425
FAM103A1	Pathway Commons Protein-Protein Interactions	1.0	null
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9744
KARPAS-422	GDSC Cell Line Gene Expression Profiles	-1.0	-1.74654
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269278
cellular process	GO Biological Process Annotations 2015	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36777
HRI	Kinase Library Serine Threonine Kinome Atlas	1.0	null
DDX50	Pathway Commons Protein-Protein Interactions	1.0	null
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02058
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IL16	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14817
DGAT2L7P	Pathway Commons Protein-Protein Interactions	1.0	null
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.60264
TEX10	Pathway Commons Protein-Protein Interactions	1.0	null
CWF19L1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K08982277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68266
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97623
SRSF5	Pathway Commons Protein-Protein Interactions	1.0	null
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
Epilepsy_lymphoblast_GSE7486	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.59694
TUBG1	Pathway Commons Protein-Protein Interactions	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70271
hsa-miR-4491	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
USP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00854083
TIMM50	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MRPL11	Pathway Commons Protein-Protein Interactions	1.0	null
KIF20B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K33037101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49443
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82376876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86236
BRD-K51322795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07814
AP2A1	Pathway Commons Protein-Protein Interactions	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63841
KYSE-150	GDSC Cell Line Gene Expression Profiles	1.0	1.43018
BRD-K13696195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7547
DA-10-HD17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304723
H3K36me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRSF2	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASF1B	Pathway Commons Protein-Protein Interactions	1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287999
BRD-K64823749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48773
BRD-K52190624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84808
BRD-K54769228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08299
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SRSF8	Pathway Commons Protein-Protein Interactions	1.0	null
CD300LB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00437749
BRD-A19633847_PERHEXILINE MALEATE_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30264
BRD-K53447551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29856
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056893
DAP3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A46317335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45736
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTSH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437036
BRD-K27476515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27082
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32382
NARS	Pathway Commons Protein-Protein Interactions	1.0	null
TRRAP	Pathway Commons Protein-Protein Interactions	1.0	null
POLR3C	Pathway Commons Protein-Protein Interactions	1.0	null
9831_WDR5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.510919
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.29985
RBM12	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5858
CRCGN015_MCF10A.TP53.M_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1429
Influenza Viral RNA Transcription and Replication	Reactome Pathways 2014	1.0	null
SP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83818372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18533
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1128
ZNF8	Pathway Commons Protein-Protein Interactions	1.0	null
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U9-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47164766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14156
Regulation of expression of SLITs and ROBOs	Reactome Pathways 2024	1.0	null
LGALS7B	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02471
Hypothalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.834239
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.83494
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.916168
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219537
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51928
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09237
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44497547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67934
ALB	Pathway Commons Protein-Protein Interactions	1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09119
protein localization to organelle	GO Biological Process Annotations 2015	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ST6GALNAC6	Pathway Commons Protein-Protein Interactions	1.0	null
SUSD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057188
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZJ-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3918
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81999794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22494
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1939
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.550511
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14534138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18555
C8orf33	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FUBP3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42943023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73786
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16776
SOX15	Pathway Commons Protein-Protein Interactions	1.0	null
PUS7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09394
PSPC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61440521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12835
MRPL18	Pathway Commons Protein-Protein Interactions	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28901
BRD-K32079609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12547
Ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB40	Pathway Commons Protein-Protein Interactions	1.0	null
C18orf32	Pathway Commons Protein-Protein Interactions	1.0	null
DECR2	Pathway Commons Protein-Protein Interactions	1.0	null
ACIN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76661445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08754
NLRP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487213
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.37319
MRPS7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41222
PUROMYCIN	DrugBank Drug Targets	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45272
KCNH2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10089173-pnas.2208860120.sd01.xlsx-200113_Diana_XPA_Stats-Unnamed_2_XPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22093970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5076
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.87578
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
PPA1	Pathway Commons Protein-Protein Interactions	1.0	null
WSU-DLCL2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BL5777 (WTAP)	NURSA Protein Complexes	1.0	null
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12912
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0142
BRD-K14122415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2808
NCOR2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0229
HIST2H2BE	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GBP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646637
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.84253
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34311186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28707
BRD-K71427375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07186
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_NK_cells-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26811
T24	BioGPS Cell Line Gene Expression Profiles	1.0	0.910035
ASCC3	Pathway Commons Protein-Protein Interactions	1.0	null
CUL4B	Pathway Commons Protein-Protein Interactions	1.0	null
TEFM	Pathway Commons Protein-Protein Interactions	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85153
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTHFD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02061146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33494
HCC1171	CCLE Cell Line Gene CNV Profiles	1.0	1.4882
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.774935
HELA	BioGPS Cell Line Gene Expression Profiles	1.0	1.04094
transport	GO Biological Process Annotations 2015	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22485581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41632
CKAP4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70283
PES1	Pathway Commons Protein-Protein Interactions	1.0	null
FZR1	Pathway Commons Protein-Protein Interactions	1.0	null
ERBB2IP	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12	Pathway Commons Protein-Protein Interactions	1.0	null
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.730721
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6642_PPM1G_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.15233
IRF4	ENCODE Transcription Factor Targets	1.0	null
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47071
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95768123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20287
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11003742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02434
POU4F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26461
RRS1	Pathway Commons Protein-Protein Interactions	1.0	null
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.786
CSTF3	Pathway Commons Protein-Protein Interactions	1.0	null
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.952439
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77063
BRD-K54453373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12388
ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K72317601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71942
RFC3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Urinary bladder squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
RBM19	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03441
HMGB3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63825
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.403248
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05389
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874574
GB-01-UN23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225708
BRD-K18262761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05548
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25805
PKDCC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505034
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
RLF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43152
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26396
BRD-K94582694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12783
structural molecule activity	GO Molecular Function Annotations 2015	1.0	null
MTHFD1L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34861
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K82863660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4127
KRT9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19382
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15019832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26955
colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.211261
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06997
BRD-K77797589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40907
CREB3L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00818178
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00313
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2742
TUBB1	Pathway Commons Protein-Protein Interactions	1.0	null
Translation	Reactome Pathways 2024	1.0	null
ATIC	Pathway Commons Protein-Protein Interactions	1.0	null
PDLIM4	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3163	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.14014
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21251
u266	HPA Cell Line Gene Expression Profiles	-1.0	-1.02965
GFAP	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.86315
BRD-K39668479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12755
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.78046
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF787	Pathway Commons Protein-Protein Interactions	1.0	null
4737_LZTR1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.01043
BRD-K66889220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27745
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.891961
YAE1D1	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5239
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60503
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84882
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.868175
HAVCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602828
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0914
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456543
RUNX1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896702
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K59571728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08556
SFXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0076643
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20215
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARP2	Pathway Commons Protein-Protein Interactions	1.0	null
EB-09-OC36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288303
SPCS3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KPNA4	Pathway Commons Protein-Protein Interactions	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_706_KD_SETDB1_SRP116955	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30717
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22443
LYSP100-associated nuclear domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.966
XRCC1	Pathway Commons Protein-Protein Interactions	1.0	null
Metabolism of amino acids and derivatives	Reactome Pathways 2024	1.0	null
single-organism membrane organization	GO Biological Process Annotations 2015	1.0	null
SW900	CCLE Cell Line Gene CNV Profiles	1.0	2.12728
EIF2AK2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K22591777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11675
XYLT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K34425773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24727
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948452
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21916
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.32997
GTPBP10	Pathway Commons Protein-Protein Interactions	1.0	null
protein targeting to er	GO Biological Process Annotations 2015	1.0	null
BRD-K15931098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19713
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.46515
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIFC1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8458
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.55728
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPP1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532922
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.438658
Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU349	CCLE Cell Line Gene CNV Profiles	1.0	2.1883
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Major pathway of rRNA processing in the nucleolus and cytosol	Reactome Pathways 2024	1.0	null
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ribosomal protein L26/L24P, eukaryotic/archaeal	InterPro Predicted Protein Domain Annotations	1.0	null
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
RPA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28261
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.864403
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54351451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10525
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.67
RPS29	Pathway Commons Protein-Protein Interactions	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75154
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
CEBPE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604756
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33584
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65594
BRD-K51003626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49113
BRD-K57516590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65503
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8692
osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.360782
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.885542
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29558
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945657
ACTG2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TRIM25	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46494135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03133
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82055
C20orf57	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ETS1	ChEA Transcription Factor Targets	1.0	null
HS852T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90699
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
HK1	Pathway Commons Protein-Protein Interactions	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0432
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11693
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	1.11838
NUP88	Pathway Commons Protein-Protein Interactions	1.0	null
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257637
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982175
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.95104
nucleobase-containing compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K01734019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96301
BRD-K91576495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04499
organelle	GO Cellular Component Annotations 2015	1.0	null
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25987
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50497551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30317
GIMAP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048073
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02843
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4456
POLR2I	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43744
POLR2E	Pathway Commons Protein-Protein Interactions	1.0	null
CPSF1	Pathway Commons Protein-Protein Interactions	1.0	null
SNU410	CCLE Cell Line Gene CNV Profiles	1.0	1.94695
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDHA2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978876
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26872015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24962
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AFF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08129
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90762344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75098
GSE210718_1_v_0_shmt2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA10	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20445
ZNF195	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100654_HIP_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03119
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096361
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K09100418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38203
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16848
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5O	Pathway Commons Protein-Protein Interactions	1.0	null
LUC7L2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13390322_AT-7519_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5245
STAT5A	ENCODE Transcription Factor Targets	1.0	null
CTCFL	ENCODE Transcription Factor Targets	1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05672
CSNK1A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34066
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3126
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8996
BRD-A89471191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44122
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-STAT3_target_genes_in_N1-GOPC_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
NSL1	Pathway Commons Protein-Protein Interactions	1.0	null
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
EHHADH	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K94858557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2776
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71932
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81315
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macrocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.788033
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38088
srp-dependent cotranslational protein targeting to membrane	GO Biological Process Annotations 2015	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57121
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6895612-EMMM-11-e10835-s005.xls-Overlap-Exogenous_circ-CUX1_MS_CUX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04010869_PROSTAGLANDIN A1_CL34_6.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23972
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44023
USP7	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S2-HSF1_CanSig_Genes-HSF1-CanSig_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89459607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1068
TUBB2A	Pathway Commons Protein-Protein Interactions	1.0	null
LSM1	Pathway Commons Protein-Protein Interactions	1.0	null
PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
Eukaryotic Translation Termination	Reactome Pathways 2024	1.0	null
BRD-K24496049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03513
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.988518
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CD96	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636683
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286026
PMC4090731-bjc2014262x1.xls-Sheet1-CaSig-HSF1_Positive_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7452
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL14	Pathway Commons Protein-Protein Interactions	1.0	null
DHX16	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K00081911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0426
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Reactome Pathways 2014	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35668999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17005
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.21624
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80210288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11866
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98408574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37387
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845716
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FXR1	Pathway Commons Protein-Protein Interactions	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.24025
SIRT6	ENCODE Transcription Factor Targets	1.0	null
RPLP2	Pathway Commons Protein-Protein Interactions	1.0	null
C7orf50	Pathway Commons Protein-Protein Interactions	1.0	null
CDH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00410136
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17152
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
NRF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
EMD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00850124
BRD-K60862683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9418
JB-89-SI60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.480937
PALD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5191
Perturb_5943_KD_POLDIP3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.71819
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237054
establishment of protein localization to membrane	GO Biological Process Annotations 2015	1.0	null
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74973
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC3630382__F10	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K30462643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46008
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.507
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69349031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82573
HNRNPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30916
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.121
FGF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15778
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953521
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22031
Nonsense-Mediated Decay (NMD)	Reactome Pathways 2014	1.0	null
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1611
MCCC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542557
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332306
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26866198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16015
USP10	Pathway Commons Protein-Protein Interactions	1.0	null
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7338_KD_TP53_SRP350326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.7889
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4943
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.23113
MRPL40	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NPC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00319173
TCF12	ENCODE Transcription Factor Targets	1.0	null
LRP1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26576
RPL18	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832592
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.0634
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
a-Naphthoflavone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSD17B4	Pathway Commons Protein-Protein Interactions	1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.921424
DUT	Pathway Commons Protein-Protein Interactions	1.0	null
YTHDC2	Pathway Commons Protein-Protein Interactions	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880123
HIST1H2AI	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.52943
MCF2L2	Pathway Commons Protein-Protein Interactions	1.0	null
MUC3A	Pathway Commons Protein-Protein Interactions	1.0	null
BAHCC1	Pathway Commons Protein-Protein Interactions	1.0	null
GLC82	CCLE Cell Line Gene CNV Profiles	1.0	2.52606
BRD-K36149853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03976
MRPS26	Pathway Commons Protein-Protein Interactions	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ISY1	Pathway Commons Protein-Protein Interactions	1.0	null
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.997796
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K09602097_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54449
COPI vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.876
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAJIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71959
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52Q-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076378
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATP1A2	Pathway Commons Protein-Protein Interactions	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K03675705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67851
ACMSD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00829798
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
SNX19	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
POLR3D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K97867712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40612
PLOD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00309307
BRD-K86792405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66825
BRD-K38424085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8947
MRM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNAI1_01_69	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61205
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GOLIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5978
EXOSC1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL35A	Pathway Commons Protein-Protein Interactions	1.0	null
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
TFG	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900601
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.879167
ZNF552	Pathway Commons Protein-Protein Interactions	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5525
AP4B1	Pathway Commons Protein-Protein Interactions	1.0	null
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441766
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IFI16	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peptide chain elongation	Reactome Pathways 2024	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75389
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.202
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H4-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
umbilical artery	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-0.777136
BRD-K48900723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52537
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.867863
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSDL2	Pathway Commons Protein-Protein Interactions	1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26446
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDST8_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.66378
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987745
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
201T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6738
nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZC3HAV1	Pathway Commons Protein-Protein Interactions	1.0	null
Formation of a pool of free 40S subunits	Reactome Pathways 2014	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFC1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21287
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Selenocysteine synthesis	Reactome Pathways 2024	1.0	null
Perturb_17480_KO_IGF2BP1_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.60849
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66106
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65025
RASGEF1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644452
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.25695
COPS5	Pathway Commons Protein-Protein Interactions	1.0	null
AIM2 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56408846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01998
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
SHE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5106
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81318113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25886
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.021
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K60850201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35137
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77801455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97623
SRSF11	Pathway Commons Protein-Protein Interactions	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32647
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041237
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892521
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
ANISOMYCIN	DrugBank Drug Targets	1.0	null
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.88178
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EEF1G	Pathway Commons Protein-Protein Interactions	1.0	null
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
GTP hydrolysis and joining of the 60S ribosomal subunit	Reactome Pathways 2024	1.0	null
GLTSCR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A89237309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18049
WDR45B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08425
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990277
PMC5998130-41467_2018_4619_MOESM7_ESM.xlsx-specificity_NCOA3-Gene_Name_NCOA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHRNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563077
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.416511
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121283
USP39	Pathway Commons Protein-Protein Interactions	1.0	null
CHAF1A	Pathway Commons Protein-Protein Interactions	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.660736
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
NAAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13231
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMU1	Pathway Commons Protein-Protein Interactions	1.0	null
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.927037
GPC6	Pathway Commons Protein-Protein Interactions	1.0	null
Viral Infection Pathways	Reactome Pathways 2024	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
NOB1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1762
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPA7	Pathway Commons Protein-Protein Interactions	1.0	null
CEACAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568651
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.58719
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADAMTS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05669
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.22322
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Reactome Pathways 2024	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.942552
MRPL48	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82793574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12926
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XKRX	Pathway Commons Protein-Protein Interactions	1.0	null
RELA	ENCODE Transcription Factor Targets	1.0	null
AMPD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39223685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39196
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
MRE11A	Pathway Commons Protein-Protein Interactions	1.0	null
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.471236
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
LBX2	Pathway Commons Protein-Protein Interactions	1.0	null
PCNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77876
NUP210	Pathway Commons Protein-Protein Interactions	1.0	null
CRYZ	Pathway Commons Protein-Protein Interactions	1.0	null
SUB1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69855
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13813
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0752
BICR22	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65879
TAF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82126187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21266
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02558
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular transport	GO Biological Process Annotations 2015	1.0	null
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
GABARAP	Hub Proteins Protein-Protein Interactions	1.0	null
CCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555796
Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HP1BP3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_16970_KD_AJUBA_SRP253076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78195
BRD-K22683888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80266
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
PRG4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K62511698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05963
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	183.715
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.04231
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.660105
BL3800 (PALB2)	NURSA Protein Complexes	1.0	null
MRPS23	Pathway Commons Protein-Protein Interactions	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352012
BRD-K69229416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04453
BRD-K96075847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6704
BRD-K67572910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39187
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955494
PC-18-VX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209535
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84956
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDCD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14861
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA_high-signal_selected_bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GEMIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04227
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14375485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72861
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP2R5A	Pathway Commons Protein-Protein Interactions	1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383194
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08892
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25323
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDR_knockdown_119_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.95856
CMAS	Pathway Commons Protein-Protein Interactions	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
BRD-K42671261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52631
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.745638
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H1F0	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPA	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A57982699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53628
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11594
Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6562
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FEN1	Pathway Commons Protein-Protein Interactions	1.0	null
leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.40672
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32585
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22925
GTEX-XMK1-1326-SM-4B65Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865109
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20139
EIF2S3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3412-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.882503
PCCB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98601267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31664
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55863
COLO-205	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-5.31558
BRD-K02708799_GSK-1059615_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ADAM15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537642
RPL34	Pathway Commons Protein-Protein Interactions	1.0	null
UTP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22056
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47283
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47765
RPL18A	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56341841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28217
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
EIF3F	Pathway Commons Protein-Protein Interactions	1.0	null
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETDB1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
scoulerine-1742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GEMIN5	Pathway Commons Protein-Protein Interactions	1.0	null
DNA recombinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.54
LRRC37A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654045
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882305
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.58374
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06831
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
vesicle	GO Cellular Component Annotations 2015	1.0	null
FCRL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539201
IK	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32913479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49729
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22722
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP18	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
RBM17	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74163
MTRF1	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33079
BRD-K87640319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16381
TFPI	Pathway Commons Protein-Protein Interactions	1.0	null
KRT13	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3690_KD_NUF2_SRP352847	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.16141
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A9QD-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3443648-1752-0509-6-89-S1.xls-Sheet1-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61G-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04538
CBFB	Pathway Commons Protein-Protein Interactions	1.0	null
PROCR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00457119
ASCC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V955-0126-SM-4JBH5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846171
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4657	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
OVCAR4	CCLE Cell Line Gene CNV Profiles	1.0	1.68179
USF1	ENCODE Transcription Factor Targets	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX	Pathway Commons Protein-Protein Interactions	1.0	null
NCAPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567753
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
DDX23	Pathway Commons Protein-Protein Interactions	1.0	null
NMT1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35528
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480743
BRD-K90826279_-666_HA1E_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02394
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37956279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37881
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
SLC18A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614912
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63537
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALKBH5	Pathway Commons Protein-Protein Interactions	1.0	null
sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.314409
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18236
RBBP4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05095
BRD-K65005459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69675
SON	Pathway Commons Protein-Protein Interactions	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.991574
MORF4L2	Pathway Commons Protein-Protein Interactions	1.0	null
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467892
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.425
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2574
BRD-K45472595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49846
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54213
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.446314
inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.847779
Eukaryotic Translation Elongation	Reactome Pathways 2024	1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434323
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0413
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10023
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03521
H3K36me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9363
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22503
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854868
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34961
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66993610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37259
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
shsy5y	HPA Cell Line Gene Expression Profiles	-1.0	-0.860464
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73481
protein localization	GO Biological Process Annotations 2015	1.0	null
ZC2HC1A	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1654
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57584
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31707
PPP2R2B	Pathway Commons Protein-Protein Interactions	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043804
RBMXL2	Pathway Commons Protein-Protein Interactions	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IL1B	Pathway Commons Protein-Protein Interactions	1.0	null
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.86103
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GJB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580614
NELFE	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A91891312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1022
H3K36me3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14268
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20813
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.689573
GSE48812_8_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
protein targeting to membrane	GO Biological Process Annotations 2015	1.0	null
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343757
metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
EEF1A2	Pathway Commons Protein-Protein Interactions	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16453
TFB2M	Pathway Commons Protein-Protein Interactions	1.0	null
GRM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00734833
LUZP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60768
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13494
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27956
ELK1-19687146-Hela cells-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K23192422_L-6307_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23192422_L-6307_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF518A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MXRA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00737069
QKI	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75983763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46285
8890_THOC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.516172
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11127
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24269
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.323825
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05201
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21408
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pleomorphic adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
AKAP8	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3G	Pathway Commons Protein-Protein Interactions	1.0	null
DLG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0100892
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208941
EIF3A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A61014366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11377
NDUFA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00504
HPBALL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91079
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881338
LRRC59	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF45	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910536
RPL10	Pathway Commons Protein-Protein Interactions	1.0	null
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63713
ZNF354B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS27	Pathway Commons Protein-Protein Interactions	1.0	null
PEG10	Pathway Commons Protein-Protein Interactions	1.0	null
ADD1	Pathway Commons Protein-Protein Interactions	1.0	null
NAA38	Pathway Commons Protein-Protein Interactions	1.0	null
ICAM1	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6468
ZNF586	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01103048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51834
CNOT11	Pathway Commons Protein-Protein Interactions	1.0	null
Hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEXIM2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908692
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2813
efo21	HPA Cell Line Gene Expression Profiles	1.0	2.00471
Disease	Reactome Pathways 2014	1.0	null
GS-9620	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
NEFM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593164
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9107
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.9879
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1144
blood	GTEx Tissue Gene Expression Profiles	-1.0	-0.837785
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34894
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61436
ALL-PO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.89405
HADHB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AURKB	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.46029
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99867
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
BRD-K58208155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24606
BRD-K32949071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7796
IPO8	Pathway Commons Protein-Protein Interactions	1.0	null
ZC3H7B	Pathway Commons Protein-Protein Interactions	1.0	null
KCTD12	Pathway Commons Protein-Protein Interactions	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.826887
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HIST1H2BJ	Pathway Commons Protein-Protein Interactions	1.0	null
COBLL1	Pathway Commons Protein-Protein Interactions	1.0	null
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34166
TA-10-KH35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233039
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00942
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.861205
RCOR1	ENCODE Transcription Factor Targets	1.0	null
ATG4B	Pathway Commons Protein-Protein Interactions	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17255
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
NCOA7	Pathway Commons Protein-Protein Interactions	1.0	null
RET	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482512
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889856
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Metabolism of proteins	Reactome Pathways 2014	1.0	null
PDSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058858
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Axon guidance	Reactome Pathways 2024	1.0	null
BRD-K68060538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60024
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04839
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.49739
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901006
AGK	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28596340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03919
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043616
CCM2L	Pathway Commons Protein-Protein Interactions	1.0	null
INCENP	Pathway Commons Protein-Protein Interactions	1.0	null
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03788
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.872981
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GN-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF6	Pathway Commons Protein-Protein Interactions	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403893
Influenza Life Cycle	Reactome Pathways 2014	1.0	null
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15535
KRT71	Pathway Commons Protein-Protein Interactions	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21254
POLR2A	ENCODE Transcription Factor Targets	1.0	null
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9172
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00291
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48532
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36908
BRD-K41829399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13536
SMYD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487477
GABARAP	Pathway Commons Protein-Protein Interactions	1.0	null
EIF4H	Pathway Commons Protein-Protein Interactions	1.0	null
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37819
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0279
PMC10025425-mmc3.xlsx-ADNP_WH-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
TRAK1	Pathway Commons Protein-Protein Interactions	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.525315
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410132
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36777
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22089
Perturb_5992_KD_ZNF512_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.50444
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9227
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.816022
BRD-K27008344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19529
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40935
SET2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85494
MOGS	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412272
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09468
CRCGN015_MCF10A_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08955
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224084
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ADNP	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CASC3	Pathway Commons Protein-Protein Interactions	1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224855
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922587
NB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45941
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44796
Eukaryotic Translation Initiation	Reactome Pathways 2014	1.0	null
CTCF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBA52	Pathway Commons Protein-Protein Interactions	1.0	null
AURKA_knockdown_89_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.69867
NOLC1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7293_KD_U2AF35_SRP116787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2822
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.54751
ASXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28178
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC25A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03983
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3630382__F10	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K37398853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38996
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11347
GTEX-QEG5-1426-SM-447AS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845888
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15888
BRD-K32423836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00883
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.8609
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A68N-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
MFHAS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03618428_PP-110_PC3_24.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0629
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83065
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38129
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PITX2	Pathway Commons Protein-Protein Interactions	1.0	null
HIST3H2A	Pathway Commons Protein-Protein Interactions	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27308
CLTCL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45112293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97899
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
C4A	Pathway Commons Protein-Protein Interactions	1.0	null
DDX55	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32741
NOMO2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10130686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2123
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SH3BGRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07996
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
SW1573	GDSC Cell Line Gene Expression Profiles	1.0	1.4344
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EEF1A1P5	Pathway Commons Protein-Protein Interactions	1.0	null
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04704
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF326	Pathway Commons Protein-Protein Interactions	1.0	null
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01898
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.76518
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11889
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942178
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12324
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.121
skin	HPA Tissue Gene Expression Profiles	-1.0	-1.08763
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WW-01A-22R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
FZD10	Pathway Commons Protein-Protein Interactions	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.02648
IL10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689667
BRD-K32882942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23715
CRCGN009_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21164
BRD-K46119789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59025
CD200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19088
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90996
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6428271-pone.0213813.s007.xlsx-LPS_anti-IL-10_significant_GOs-ensembl_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DHX58	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05128
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.92546
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THRAP3	Pathway Commons Protein-Protein Interactions	1.0	null
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.26503
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05417
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
Ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64382
MGMT	Pathway Commons Protein-Protein Interactions	1.0	null
UNC80	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97153
MELJUSO_SKIN	CCLE Cell Line Proteomics	1.0	4.10526
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40274
BRD-K67740871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72969
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88392
878_BPHL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.702517
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.723381
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.896339
ATG3	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
macromolecule localization	GO Biological Process Annotations 2015	1.0	null
PML	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8235
RBM27	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1-21572438-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01322
BRD-K86545229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21587
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null