association	dataset	threshold value	standardized value
death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.637
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurofibroma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_Name_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0752
GSE138863_2_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMBC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185744,GSE185747_2_v_3_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25464
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546947
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168024
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38584
Mycolate outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.534
Osteosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.208
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fibrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183449
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.385
Lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.782
PC-12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.577
Elementary body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Myeloma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.761
Cervical ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.748
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6202
GSE182179_2_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Solid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.435
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423463
Hepatoblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
SUDS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90807
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	2.00998
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291367
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00793
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0431
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29004
Pancreatic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.482
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.998
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.20532
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.559
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-toNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine endometrium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.534065
AC-10-JK64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492256
GSE215461_0_v_1_topotecan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.4596
MRPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26037
GD-73-ZF64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262664
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145459
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
SREK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55278
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9678
HOSE 6-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
Mammary epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.378
Mesothelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.974
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03968
Spinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.256
22q11 2 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344194
Lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.913
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.793
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
CRCGN017_MCF10A.WT.HP_24H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0062
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE(2)-M17 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.5329
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
1067_RTL10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.902985
e1a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
SURF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24453
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.689
K562_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015899
Mitotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.498
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16886
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
Adenoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
CHOP-C/EBP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.794
Prostate carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
Distal tip cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.258
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29569
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211424
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
ST6GAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17488
T-lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.687
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.256
1812_COX19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663256
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.755
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019825
Apoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.773
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328169
SK-N-AS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.987
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.385
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.022
JHUEM-2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.12
WEHI-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.778
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91975
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50915
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52555
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
UF-61-QB73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227653
VASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04913
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325677
Follicular lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.177
CRCGN013_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4843
NCI-H157 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
RNF103	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03498
Bone structure disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.256
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7989
CUL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68495
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.639
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.664
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-55-XA97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2616
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.9729
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.904
chr22_19869038_G_A_b38	GTEx eQTL 2025	1.0	1.01143
Rhabdomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
Colonic adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55769
INKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4825
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.081
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189293
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.823293
MDA-MB-453 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.667
RAMOS-AW cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.392
SK-MEL-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00754
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8446
Mature T-cell and NK-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
Promyelocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
GSE128634,GSE128636_4_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.00366
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.73464
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.0951
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE71468,GSE76476_2_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72537
Burkitt lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.381
Endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.335
DAUDI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25295
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296346
MCF-10A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
NCI-H1792 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.794
TET2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9352
MRPL52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06789
Carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.308
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.998
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Oral squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
Phosphatidylinositol 3-kinase complex, class I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Phagophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.732
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.088
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Endoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.782
BL-41 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.385
Promonocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.503
GTEx Prostate 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-4.42744
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
7141_RBBP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.649277
Lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.773
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.74
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
Mel-RMU cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
Autoimmune lymphoproliferative syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	1.34738
MYORG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53419
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.3949
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.998
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
igr1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.832901
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.017
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.502786
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.069
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217584
ri1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
SYT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07699
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.855298
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-HEP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
Prostate gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.692
GSE109111_2_v_0_stim1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nasopharyngeal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.61601
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.102
H-1299	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178066
GSE173201_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06787
PYDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03246
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.991555
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312385
Acute promyelocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473792
chr22_19847587_C_T_b38	GTEx eQTL 2025	1.0	1.46438
Pheochromocytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.584
lb24	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.06
FL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209601_2_v_3_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brown Pearce carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
SH-EP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.189
PRR29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0204
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erythroid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.248
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H9c2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.205
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170424
HIR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
Burkitt lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.92
Mitochondrial permeability transition pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.019
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.613164
Liposarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.69
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281117
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.952
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.656198
Leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.268
HT-1080 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.975
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
Reticulate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
SW-620 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.041
T-lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7072
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reticulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.043
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4709
B-cell acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6085
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.066
HEPA 1-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANKRD35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15757
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141152
B-lymphoblastic leukemia/lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
Membrane fusion priming complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.708
Mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.012
K562_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017237
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-468 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.074
Fibrosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.157
Lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.886
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.49112
Lung adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skeletal muscle cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.991
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.1213
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525104
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
Mammary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.39
Exopher	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.067
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MiaPaCa-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.953
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406258
HOSE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.67059
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.831
Cell envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.252
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
NRK-52E cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13927
PIKFYVE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31473
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.255
GSE224131_5_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6674
Dang	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
PMC4029819-pone.0098069.s006.xlsx-Sheet1-Table_S5_FSS_analysis_of_FOXA1_high_versus_FOXA1_low_cases_in_metastases_p-value_0_01_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.238
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8197
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270856
NFYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76012
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
JHU-029 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
Ovary adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.356
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Chronic lymphocytic leukemia/small lymphocytic lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.47
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.242
PSME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07722
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
AE-67-FF84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.513038
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.311
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521385
K562_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213159
Myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.878
Fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.79
ATPAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13612
GSE207787_3_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
Calu-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
Scoliosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.256
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.618
OVCA-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.284
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
Extrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.606
Reticulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.463
Lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.874608
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6939
RPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06701
Prostate cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.724
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	2.58588
MEF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.659
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271427
SOWAHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08754
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7341
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.238
SAOS-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.148
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277655
Mitochondrial respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
K562_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022783
Secondary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.779
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2956
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.8181
MRPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06162
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.835632
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erythroleukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
rpmi7666	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
1205-Lu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36763
DIMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25922
Epstein-Barr virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
IgM B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
Retinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29151
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91716
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.054
CA-46 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.006
GSE147240_3_v_1_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100495_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14282
Polycystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
Calpain complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.357
GSE209698_2_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.725
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
non-small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.731
KMS-11/TKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
Amphisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
mitochondrial outer membrane permeabilization	GO Biological Process Annotations 2025	1.0	null
GSE152246_0_v_1_dihydrotestosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NAALADL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51873
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2279
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.97409
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Superior cervical ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
Leukemic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.152
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159829
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.992
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4099
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.637
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269024
Cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.071
COLO-357 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
Vas efferens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.895
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394934
K562_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224474
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284363
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22773
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.577082
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.78865
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.98659
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.724
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.256
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6998
Amyotrophic lateral sclerosis type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
CRCGN015_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26739
Follicular lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
MEL-HO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167223
DNA gyrase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.429
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.39
Bile duct cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHOP-ATF4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.97342
Small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1272
AGBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17538
Leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.963
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.59319
Melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.83
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172444
IkappaB kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.323
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.904
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.7148
Tongue cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
GSE73628_8_v_2_igf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28108
GPX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01802
Cystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hypersensitivity reaction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7538
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
Cardiomyoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.523
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
GTEx Blood 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-3.58759
EHBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38788
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mammary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.443
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.983
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Eye disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.998
ED-81-ZH14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317208
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285721
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
T-cell non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184399_0_v_3_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
non-small cell lung adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.579
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88016
Breast cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.965
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30356
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.633882
Myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.74
NDUFA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02143
IGROV-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.121
GSE139540_3_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.267
b95.8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
CRCGN014_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36641
Oligodendroglioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.618
Agranulocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56114
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160077
ITCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12184
Adrenal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.542
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.881
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
pre-B acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.206
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54313
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123943_4_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL39L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53482
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
CRCGN013_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13885
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272556
Lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.856
BT-549 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.889
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284313
Calu-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578985
Myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.948
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15475
Skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.018
MAN2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29494
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.699
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534862
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443581
Activin responsive factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.454
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137041
GPR25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34926
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04568
Mantle cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.039
Cervical intraepithelial neoplasia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.132
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.969
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and neck squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.252
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3013
GSE196117_1_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.72
regulation of mitochondrial membrane potential	GO Biological Process Annotations 2025	1.0	null
Pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.999
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29395
Chronic myelomonocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
RPMI-7951 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
Primary cutaneous T-cell non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
GTEx Breast 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-3.42727
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62146
positive regulation of mitochondrial membrane permeability involved in apoptotic process	GO Biological Process Annotations 2025	1.0	null
DDX51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.034
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plasma protein metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
chr22_19846466_G_A_b38	GTEx eQTL 2025	1.0	1.5791
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285079
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260044
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.748
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175333
Mesothelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.135
Mel-CV cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.064
PMC12885947-44386_2025_32_MOESM1_ESM.pdf-23-ZNF469_ZNF469	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025758
GSE167546_1_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.481
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PC-68-DU31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369944
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185267
WEHI-231 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.442
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial intracristal space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Endoplasmic reticulum subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.906
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3877
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.935
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endopeptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.328
Colonic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.657
GSE202434,GSE202438_7_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_26_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Pars compacta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.998
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.585
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.643
BGC-823 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.731
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14293
Gastric epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.635209
chr22_19779897_A_G_b38	GTEx eQTL 2025	1.0	2.7523
K562_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158113
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.694
Colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.811
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.29095
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.896
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MOLT-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.1
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bile duct adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Erythroleukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
interleukin4-interleukin-4 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.631
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75597
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
Pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Downregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
chr22_19873329_T_C_b38	GTEx eQTL 2025	1.0	2.00539
Pleural fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.479
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
Chronic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.959
SW-872 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99405
MIN6-N8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
SOCS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.561
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174727
Pancreatic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.975279
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
LAN-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.93192
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.56118
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95818
Urinary bladder cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20267
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.775417
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
PMC5474565-onc2016488x2.xlsx-Table_S6_MA9_Enhancers_-_Genes-Genes_Closest_to_MLL-AF9_enhancers_within_the_same_TAD_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF536	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36091
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411306
Traumatic brain injury	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
HOOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67357
Acute promyelocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
Adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3958
Gastrointestinal stromal tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
HMEpC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
BIM-BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.316
Cytoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28178
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.63
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71507
chr22_19875619_T_C_b38	GTEx eQTL 2025	1.0	1.18457
Dehydrodolichyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
BST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39723
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6707
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-26-LE04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272873
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
T-cell acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.359
Atg12-Atg5-Atg16 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.931
SOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13963
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.988
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
SLC4A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03472
Cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.546
K562_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199254
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
M cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.26
RKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
5896_NUP43_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.511714
RT-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
open-angle glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.998
Atg1/ULK1 kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.674
Lysosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.533
GTEx Skin 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-6.0038
Myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.813
SK-MEL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
Colo-205 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.113
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.713
Glioblastoma multiforme cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.361
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.55243
RPL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53642
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCT-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
CHAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00021
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.53812
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.720847
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4915
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2633_EN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.639002
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TORC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.303
661W cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3651
CRCGN015_HEPG2_48H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1359
NCI-H929 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.305
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43385
Gastric epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.955
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.97407
HeLa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.07
Nerve sheath cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
pre-T cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.884
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.759877
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.777413
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67106
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.222
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.063
Pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.693
Eca-109 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.572691
Blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
Fibroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.156
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ca96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PICALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26201
CNOT6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34898
SK-BR-3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
U-266 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.221
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.0172
IKZF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26995
MPHOSPH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11138
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.833
Chondrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60831
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.119
PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70518
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279691
Adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.247
Granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.462
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Astrocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.644
Omegasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.878
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.7009
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6212
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitotic checkpoint complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.789
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23833
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mel-RM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.82505
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182781
CRCGN016_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29662
Cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.406
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211349
Proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.335
PPP1R16B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2618
CRCGN013_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14645
SKOV-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.347
Diffuse large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.865
Disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.163
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0301125
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
DLD-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.327
Melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.022
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416098
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539144
B95-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
RAJI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
Chronic myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
ZNF143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25488
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8762
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81258
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19599
AGAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00606
NALM-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.066
Organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.795
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26271
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.748
Phosphatidylinositol 3-kinase complex, class III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.77
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11963
NCAPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29763
Fibrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.072
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79123
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497304
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.14
Upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
BIM-BCL-xl complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.305
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KARPAS-422 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
WEHI-7.2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.198
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.859
Resting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.092
VPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.785
ZNF282	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23929
MEWO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.551
Multiple myeloma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.67
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07973
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UNC5CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55639
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.936639
IHH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
Dami cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
GSE172146_2_v_1_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73142
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.922077
Large cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
Autolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.842
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36177
GSE223893_4_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.915644
Latii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.822
Autoimmune lymphoproliferative syndrome type 2B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594549
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
chr22_19869684_C_T_b38	GTEx eQTL 2025	1.0	1.85966
DU-145 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.364
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.74
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.01825
Gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.833
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-9-TBX3_TBX3	Rummagene Transcription Factor Associations 2026	1.0	null
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
MSTO-211H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_down-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
RPAIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53307
opm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.292
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.651
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.976546
GSE240444_2_v_3_idasanutlin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OE-33 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
GOSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05725
Organelle envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.165
K562_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0257
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
APOBEC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18325
Plasma cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
GE-47-OO30_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302986
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41108
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HL-60 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.533
BxPC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.591
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1059
Carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.434
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326712
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.13329
CRCGN008_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0156
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7473
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12358249-supplementary_table_s5_ioaf064.xlsx-DMRT1_-_vs_WT__4_months-Unnamed_1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
non-Hodgkin lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.72
Sympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227686
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.752393
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.982
Catalase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.407
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.816274
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.385
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185094
FOXG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45586
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.595718
T-24 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.806
HOG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46137
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.515
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.068
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322929
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7395
Retinal cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Leading edge of axonal growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.506
ITGB1BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52854
ML-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.145
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
DNA-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
FAM168A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05765
GSE158834_1_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.772
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35579
LNCaP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.413
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.104
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19075
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178392
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Myelodysplastic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.66436
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.7061
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54941
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25568
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.00968
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.513
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.82747
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7146
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.704
Autophagosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.207
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467232
K562_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192487
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0329
496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08632
Dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.713
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712596
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0272704
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43226
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7805
NAT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24803
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BV173 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564739
chr22_19854787_G_A_b38	GTEx eQTL 2025	1.0	1.58312
STON2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01901
GSE143944_1_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4060771-170289.f1.pdf-537-TEAD3_TEAD3	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
Metabolic dysfunction-associated steatohepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
4696_LSM6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.547577
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3953
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.5748
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
IGR-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0777
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208389
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cyclin D1-CDK4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
B-cell chronic lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
TPRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83407
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.688
Cholangiocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.39629
SORT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23209
SEC61G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31131
GSE226770_3_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418563
Ser-W3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
BT-474 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MV4-11 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
TMEM35B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1388
Hypersensitivity reaction type IV disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
Blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
Neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
BAK complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.464
RAD18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60347
dohh2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
Bile duct carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229694
3706_HESX1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.529951
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201438
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.621871
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9818
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3506
Hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
UTP14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14503
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.998
AC-00-BR21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201517
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.643015
K562_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014462
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34237
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4697_LSM7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.561305
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.829
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypodermal seam cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.719
Oral cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.385
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201628
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.56367
GSE158834_1_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145131
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
IGBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63573
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429104
dms53	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.888
GSE230744,GSE237803_0_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1975 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428308
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94978
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
CRCGN015_HEPG2_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04246
Hypopharyngeal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19782
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
KG-1A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.605
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43183
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25992
NOXA-BCL-xl complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.805
GSE151090_2_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Germinal center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.336
HeLa-229 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.78
NPC-TW04 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
MOLM-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
Chronic myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.239
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31067
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Burkitt lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.368
caki2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
Aggresome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.15
CRCGN015_HEPG2_48H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1142
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitochondria-associated endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
Colorectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.736
NCI-H82 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
MB-02 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.574
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153376
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32731
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244957
K562_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210358
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4168
ZNF280A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2519
K562_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162143
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mature B-cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.898
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.2747
ATAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34769
FaDu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
T-cell acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.494
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.730627
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.851
Colorectal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271723
RBBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16382
ILKAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00062
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Proteasome core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.002
9383_TTC27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.539453
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.613533
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.455
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.91
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chronic lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.21
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
Autoimmune glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
p1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.765
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.911401
TSNAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25441
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
OCI-AML2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015781
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23701
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81812
Neuro-2a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69932
Multiple myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.525
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Blood 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-12.2315
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PIFO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21915
CRCGN015_MCF10A.WT.HP_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60324
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5452
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.31264
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37994
ZNF430	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24373
BID-BCL-xl complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.189
GSE178340_5_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.693
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253148
NCI-H460 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.124
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
Pancreatic islet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.685
SET-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
Acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.775
K562_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0301915
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58075
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
5637 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
INTS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15183
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cls1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PABIR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01847
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2272
UBL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09482
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovary cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.645
Macroglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
Lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.978
Breast adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.891
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36881
BC-63-DM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213461
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01681
Sensory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.871
L1TD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07163
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421731
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202744_1_v_0_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colorectal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.653
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.748785
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3698
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
ST3GAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03297
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MG-63 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
MCF-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.784
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.083
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207629
Lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.115
K562_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205536
JURKAT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.576
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.903
Breast epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.568
Systemic lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.435
Vacuolar membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.634
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE148321,GSE169423_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscle cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
Prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.722
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.025
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
Phagophore assembly site membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.27
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erythroid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
Endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.691
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.062
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.367
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292456
KMCH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.376
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4754
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7065
Mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.903
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.70085
Esophageal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.795
FAM110C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0426
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364391
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.127
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
pro-B-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.67
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colorectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.744
Hypopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
BAD-BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.774
Pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.689
Tumor necrosis factor receptor superfamily complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.021
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161109
PMC3853418-1756-8935-6-34-S3.pdf-29-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
Thymic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68464
GSE120612_6_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
MOLT-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0987
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0572
Pancreatic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.5
HMVEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.718
HOC-313 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.519
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12259
Organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.845
Organelle membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.398
Brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.386
K562_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199876
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-TCF7_mod_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6334
LIFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46616
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MA-10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.729224
Bile duct disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2002
Epitheloid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Astrocytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.377
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00452
TASOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65898
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9512
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.819
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1454
CRCGN015_HEPG2_48H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24556
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.41076
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9085
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21241
Pharyngeal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.957
KAT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16125
CRCGN016_MCF10A.TP53.M_24H:N24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52599
RPMI-8226 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
RC3H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15226
Lymphopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.882
imr5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
Rectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.734
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78864
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.027
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4083
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.11962
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.7153
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0597
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73249
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1374
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.797985
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GALNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13076
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59933
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501156
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.987623
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial processing peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.261
DHL-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6217
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.064
Rb-E2F complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
Cecum cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ire1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.823
Rectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.734
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.843
GSE147876,GSE147877_4_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.718
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mantle cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.789
Glioblastoma multiforme cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
BAX complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.902
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastric cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.153
Colonic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.815
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.629586
Head and neck cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.367
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoproliferative syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
Myc-Max complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NPC-TW01 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
Erythroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
GSE217776,GSE217829_2_v_0_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.722
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.501577
Epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.293
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283642
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01241
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48898
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2809
Kaposi's sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
A-549 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.575
SK-N-DZ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
Breast epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158514
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57224
Cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.848
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310775
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.97
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.29349
K562_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157455
RAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41205
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0365
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215738
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KE-07-JX81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484965
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.687
HT-29 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.498
Hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.684
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.904
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.955
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461418
Urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.218
Mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.9
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4375
RD-90-DS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2913
Renal cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.80244
Cerebellar granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.592
LYSP100-associated nuclear domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.053
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.124
MDA-MB-231 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.544
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20989
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.248
LDHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10225
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.107
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.802
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.8298
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524428
CRCGN015_MCF10A.TP53.M_24H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0018
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.754511
chr22_19839721_T_A_b38	GTEx eQTL 2025	1.0	1.77957
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
AASDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04932
CRCGN016_MCF10A.WT.HP_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36153
CRCGN015_MCF10A.TP53.M_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22196
LoVo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.013
ATP5F1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31938
Hodgkin lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395627
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.699
Chlamydia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
Myeloblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.987
PMC12532594-41380_2025_3119_MOESM1_ESM.pdf-124-ST18_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5853
BT-20 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6963
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.863
Retinoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
AB-43-XJ34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211951
Tongue cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.88
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95035
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
PC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.38
U-937 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.503
3434_GNB1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.915094
Glioblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.641
Pancreas	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.789326
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.920672
Ripoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.691
WDR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24509
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292228
A-172 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
Ubiquitin activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.678
ATP5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03247
jvm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCL-39 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50247
TBCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59519
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562601
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Colorectal adenoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.242
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.001
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3702285-cddis2013211x6.pdf-116-TBX18_TBX18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone marrow cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.907
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3094
Outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.895
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.717
Ocular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.834563
ZNF219	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70998
Mammary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.394
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5307
GSE157296,GSE157298_4_v_5_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thrombocytopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.881
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246576
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.975
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-TCF7_mod_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6783
BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.838
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.847
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31786
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
INS-1E cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	1.0	null
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.660855
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.199
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.544
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.813
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3098
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1528
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.713
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437506
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.905
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.68
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176854
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.2515
Kaposi's sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.795546
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1948
TRAIL death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.35
Intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.81
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353597
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.223
NMuMg cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.214
Lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.941
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4481
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
Squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54144
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
Nuclear outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.118
4695_LSM5_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.632008
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.2194
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59164
p3hr1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.962
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Idiopathic scoliosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.256
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.970929
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OV-202 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27294
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
Cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.072
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.853
CDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19946
Chronic lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.971
PUMA-BCL-xl complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.252
9687_UTP6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513125
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.92199
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0635
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197657
GSE184087_0_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.962
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39068
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23801
B-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.485
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	138.275
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23617
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.701
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.639
Rat-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
Endoplasmic reticulum chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.654
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225886
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Peripheral nerve sheath cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50501
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13214
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_ID_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.933
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07731
Anterior pharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.7001
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.778
Lytic vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.533
CRCGN017_MCF10A.TP53.M_24H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0399
B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.267
Gastric cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.144
GSE143406_1_v_0_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pre-B-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.585
ORC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3235
GSE103068_5_v_8_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OVCAR-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
Uterine endometrial cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.77235
RNF149	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46527
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pro-B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4892
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.624
MAGOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06972
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25809
HSFX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0502
Colonic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.811
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514911
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Follicular dendritic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Esophageal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.776
Head and neck squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.198
SK-BR-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dg2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
HA-82-XO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339763
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.273
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.573
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.59852
3434_GNB1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.798153
PMC4060771-170289.f1.pdf-108-BARX2_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PL-21	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508135
RL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
ALDOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37395
Lymphoid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.591
EXOSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32911
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.815959
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Medulloblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
Bcl-2 family protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.467
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262837
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9809
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266744
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.222
Acute myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.823
Leukopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Thyroid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5169
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.067
Urinary bladder carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020321
HARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20263
glutamate-cysteine ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
R1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
Mccoy	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.64
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36958
pre-B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.073
T-98G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
A-375 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.151
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63016
PUMA-BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.139
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213457
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEP-3B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.143
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.134
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85786
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.623
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.934297
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1541
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399353
HCT-116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
dms153	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
2125_DDX49_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27831
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09605
Autophagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.448
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.133
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
T-47D cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.024
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mammary epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.145
Mitochondrial intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.227
Glioblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.376
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGOLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18172
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.062
Blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.477
K562_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220576
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203795
PMC4682820-pgen.1005734.s014.xls-STAT1_targets-Unnamed_0_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
Cyclin B1-CDK1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
DiFi cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.864
BRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01771
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.4167
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hodgkin's lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
CIITA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04795
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6152
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.05432
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Biliary tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
CRCGN017_MCF10A.TP53.M_24H:E02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16465
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190761_0_v_1_samd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.4
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52763
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1445
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189564
Cervical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.366
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE167474_2_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.923
INTS14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73296
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.947
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.425
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.577082
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530396
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.777
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7852
Melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.382
Kasumi-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.913
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	9.0061
Rhabdomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
Sympathetic chain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
BEND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49051
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492383
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291819
9962_ZBED2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.817536
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.64686
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
Intersegmental muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.099
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thymic medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.625
K562_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195606
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.047
K562_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216001
7671_SBNO2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526991
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Unnamed_2_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.722
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.256
IGDCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07999
SH-SY5Y cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.456
Colon carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.064
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130715_1_v_0_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332393
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09177
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3267
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.591
K562_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159425
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.614441
CDC123	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75528
CRCGN017_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63855
CRCGN015_HEPG2_48H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15662
SK-N-BE(2) cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
GSE243199_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162261
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213112
nuc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.269
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56508
Acute myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.727
Blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.332
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.7862
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33153
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04737
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
Derlin-1 retrotranslocation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
Caspase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
Peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.311
Breast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.009
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.725519
U-87MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.238
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03675
Neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.369
Thymus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.94
Endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.906
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.559
CCRF-CEM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.118
GTF3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72543
B-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.244
Cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_3_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.4761
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cholangiocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.938
Pharyngeal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.982351
Ovary cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.471
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UFSP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47769
HES5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07587
Diffuse large B-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.32
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4391
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25248
pre-T-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.021
U-118MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.697
GSE202434,GSE202438_2_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Malignant peripheral nerve sheath cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184087_4_v_5_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.814
Nasopharynx carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27602
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297569
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.964963
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0743
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
Peripheral T-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SAS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.872
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181533
Apoptotic body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.839