association	dataset	threshold value	standardized value
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
TMSB15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15899
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5075
BRD-K31884664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10852
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
TNNI3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00483223
BRD-K64345025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19247
PGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00440697
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.855895
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29083
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.8923
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.404068
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.733384
Torasemide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5766
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3862
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455421
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339806
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12281552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49837
BRD-K20157822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18998
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.735506
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7064
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.2894
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100621_TCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00811
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.916369
BRD-K63730594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53154
BRD-K77392050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91525
BRD-K71574401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22437
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83122599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23592
BRD-K93819193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1254
TCF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92417
UCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492061
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13241788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79756
7493_RPP40_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19962
1972_CWC22_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.00652
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34482448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17827
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.685594
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347564
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149035_7_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217891
BRD-K27849471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4192
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.16078
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.92577
MYO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57953
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1961_CUL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07078
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.76255
HLA-DMA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532483
BRD-K97138361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19011
BRD-K34343777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43621
BRD-K38370827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87893
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.106
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3298
BRD-K00300115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58221
JA-23-QE71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286049
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261414
BRD-K22778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14997
CCKBR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00447298
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
8338_SPDL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.55603
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.223
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	56.7265
A1CF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576496
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUDHL1	DepMap CRISPR Gene Dependency	1.0	2.22054
ZMAT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591272
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AMPD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00818365
VP229	DepMap CRISPR Gene Dependency	1.0	2.62174
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240782
7067_RAD51B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611598
BRD-K74015591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78997
Avosentan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
BRD-K60017729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6956
DNMT3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20104
QB-99-OU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306448
GC-21-AN18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256114
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Von Hippel-Lindau disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
NCIH2172	DepMap CRISPR Gene Dependency	1.0	3.73572
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2
SLC7A6OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1276
FB-67-PL18_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351405
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402271
9911_XRN2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04431
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35895
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34044
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564822
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.344
BRD-K36031198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45456
BRD-K71941064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26641
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86039224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45568
JHOM1	DepMap CRISPR Gene Dependency	1.0	2.01855
Macrogamete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
CSAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0752
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8577
BRD-K02637850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16829
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17821
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IGF2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00367323
BRD-K33064128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24064
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.816794
2788_EXOSC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08033
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25099
BRD-K40964045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51954
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03644
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.69079
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.691497
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63573625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35159
TESPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00669978
NCIH446	DepMap CRISPR Gene Dependency	1.0	2.38783
BRD-K36689392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03278
BRD-K95460104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13239
MRS 2578	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.71
EDNRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00686838
496100530_FWM_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19146
NIPBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17754
ABCA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95994
CAY10683	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38771
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6603
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07781811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07169
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43105
SLCO1B3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501165
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.986652
BRD-K24076516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04929
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.51065
KB-57-TK65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20946
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70183558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05145
BRD-K75497233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22943
BRD-K87404495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63819
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262676
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61536
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.375
BRD-K94344573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14302
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.6898
BRD-K89141455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53001
496100638_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.46506
BRD-K76342376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66445
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7857
BRD-K01643633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55068
GSE240896,GSE240899_10_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ANGPTL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558657
BRD-K53931904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08052
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0018
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221491
CRCGN015_MCF10A_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44513
BRD-A13983189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34514
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2706
BRD-K44167510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21238
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Macitentan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6045
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8005
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.6069
BRD-K45367466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58954
SLC12A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571941
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02922
BRD-K70618663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58379
BRD-K85977570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97964
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.364912
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309423
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0267
5747_NOP16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15621
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466846
CLIC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523211
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CELSR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005725
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298056
5492_NCAPH_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04222
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5271
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52822
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-591-ZNF774_ZNF774	Rummagene Transcription Factor Associations 2026	1.0	null
PLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05022
BRD-K23831817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53516
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.537102
SERP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68226
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00086
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00495
CRCGN017_MCF10A.TP53.M_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1741
HSFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01948
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41219
PDE6H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603867
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-3_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
DMAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14039
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.520319
BRD-K75688032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50619
GHRHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564461
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59796
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.99762
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497278
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242002
S100A13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00422307
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22526
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38324
BRD-K74522958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04626
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8305
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58156
BRD-K83586473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26326
GPR146	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00687703
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01422
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.609697
GPR27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18992
STK11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499072
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14868
PMC8807392-41375_2021_1393_MOESM2_ESM.xlsx-data_integration-YBX1_iCLIP-targets_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53717076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0942
BRD-K58892587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12034
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.80028
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TP53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006697
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K35726223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3078
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05731
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07952
GA-89-ZT62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261196
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24135
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	159.825
AE-38-LX10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253033
WSUNHL	DepMap CRISPR Gene Dependency	1.0	5.1782
UHMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637129
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438999
BRD-K39979888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06732
ZNF474	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23002
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14314
8221_SNRNP48_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0218
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53394
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.301
BRD-K76389813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2604
S0-EE-Y6WJ_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382636
EC-67-PV87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254971
MLN4924	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.51
PASK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577023
BRD-K44298652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62724
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.503232
BRD-K04695511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8497
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.28486
OCIMY7	DepMap CRISPR Gene Dependency	1.0	2.00064
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2797
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.55945
S0-EE-Y97N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242551
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
HSDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02061
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2618
CRCGN012_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06505
SH3PXD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2978
2795_EXOSC8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01198
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29130550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56458
BRD-K63277230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22639
DB-56-XL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257377
PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25933460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68328
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K22093970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26096
TXNDC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462358
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661724
DNAJA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10268
BRD-K23728544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44646
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410907
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46137
BRD-K07013504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09607
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31939
BRD-K91962463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44946
SPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13717
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.25831
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24876
PL45_PANCREAS	CCLE Cell Line Proteomics	1.0	2.35979
GSE207301,GSE207303_0_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87238
ZBTB38	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604884
BRD-K40602242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53769
MCC13	DepMap CRISPR Gene Dependency	1.0	3.60603
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.5559
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67319345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11459
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.14584
PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA	Rummagene Transcription Factor Associations 2026	1.0	null
novobiocin-na	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.98803
BRD-K04611090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14795
FC-35-BX82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24216
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12596
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
JHH4	DepMap CRISPR Gene Dependency	1.0	3.13213
BRD-K34677894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58438
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00457283
BRD-K73039647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58285
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.29145
507_ARL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536135
HD-18-YL30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31591
EXOSC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49836
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPM6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536117
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7058
BRD-K52157065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19115
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38543
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258244
BRD-K93253774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09629
BRD-K48900723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15113
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.4301
NOP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592497
HCC78	DepMap CRISPR Gene Dependency	1.0	2.64669
FE-49-VJ28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291965
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4397
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.89015
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.671691
FA-16-HR75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458426
FE-29-XM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347073
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
7055_RAC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19136
4107_IMP3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44649
NFE2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74259
SB290157	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324764
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.5294
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.57039
Veliparib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
BRD-K95508535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10298
GSE190384,GSE190386_0_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51577639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50058
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66690073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03839
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PNLDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26141
GSE216043_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565878
BD-69-XG81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200452
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.49922
BRD-K11143221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48853
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37572
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58246
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	75.9667
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7487_RPP14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.735294
BRD-K29264158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43188
BRD-K58688519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13391
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5344
AF-12-IW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30142
CRCGN011_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07495
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17092
BCL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670779
PYHIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553318
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.578655
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40882
BRD-K11667893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67446
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300297
TNPO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46804
ERVV-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13506
RKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
FCRLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461763
GATA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00417855
GSE143662_0_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93335719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83999
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296164
BRD-K63030320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82649
Ralfinamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
QB-42-MC63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4249
PMC5732738-oncotarget-08-103415-s002.xlsx-CAMA1_DEGs-Genes_differentially_expressed_by_1_25_fold_between_parental_CAMA1_cells_and_GATA3_mutant_knock-in_clone_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690692
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	3.57901
NDUFB6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552544
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217828
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Epothilone A_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01308
16_AATF_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13384
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.2438
PMC7934853-jciinsight-6-141851-s210.xlsx-Beta3-Unnamed_0_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
Filanesib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.48
CHRFAM7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652096
FD-59-TC81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349335
BRD-K61189585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02872
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.84047
BRD-K98704738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22431
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1806
BRD-K06845853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47271
FD-72-CE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27686
2977_FASTKD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.688174
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6522
SYT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005776
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245518
BRD-K68608492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13922
BRD-K68635551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18595
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-91-BU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317114
BRD-K63864604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49268
Sinusoidal trophoblast giant cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.906
BRD-K11433244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52776
GSE147669_2_v_1_tram2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9744
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K26383086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0303
CF-48-QD87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276009
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578995
MUSK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050721
BRD-K68060538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25042
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
METAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00391228
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.8682
GTEx Colon 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	7.02538
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5312
IFNG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00392926
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.24713
GSE178714_3_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K35407043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01408
BRD-K29642620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90224
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.2034
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
COQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21621
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8309
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.5556
TLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31466
SLCO1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520382
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K029AX	DepMap CRISPR Gene Dependency	1.0	5.72458
BRD-K43918778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45407
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2268
BRD-K36583698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60896
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11585558-41467_2024_54547_MOESM8_ESM.xlsx-TP53_vs_WT_DEG_FFPE-gene_name_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GOLPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05544
GSE158632_3_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
AP2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69829
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13341
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leiomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.728
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.861964
NSC735380	DeepCoverMOA Drug Mechanisms of Action	1.0	1.1
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6751
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1958
GSTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572895
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94885
SNU475	DepMap CRISPR Gene Dependency	1.0	2.06538
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50667
BRD-K85720719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38577
Merozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.216
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.05539
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.588813
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acetazolamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
BRD-K86102179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32402
PMC11960529-mmc4.xlsx-Atrial_LHX2_KOoverCT-gene_LHX2	Rummagene Transcription Factor Associations 2026	1.0	null
BC-82-PP66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292687
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.665571
BRD-K60918542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27292
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28419
NMS-873	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.44
BRD-K69790201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05609
BRD-K90644597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61649
6962_PWP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3215
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42174
BRD-K73874262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69647
PX-12	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.904231
BRD-K28814368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44215
Autosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
P2URK562	DepMap CRISPR Gene Dependency	1.0	3.54961
GLRX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613909
BRD-K26306512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53627
CRCGN015_MCF10A_48H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04262
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36709933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00038
NCIH1793	DepMap CRISPR Gene Dependency	1.0	2.62882
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26622
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7562_RRP15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20917
GSE140997_2_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10433727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21279
PMC11951866-mmc1.pdf-5-MLXIP_MLXIP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1092
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0457
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09812
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.801
PABPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667643
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385711
CB-11-GB40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390736
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.025
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8061
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Stipe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
LE-60-VC29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200619
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	74.3655
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.463
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15795
BRD-K60807536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65058
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-11-RL84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436103
RCSD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509709
ERBB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00330608
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.0483
BRD-K08219814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42818
CRCGN015_MCF10A_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63268
ELOVL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00731335
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K29903367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0386
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Large intestine adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
ATP8B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37986
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2116
GUCY1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572054
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4271_KANSL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14261
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
RNF175	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17316
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7911
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3449
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4611
3042_FCF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.51953
SNU840	DepMap CRISPR Gene Dependency	1.0	5.58123
IGFBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05088
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.6673
PILRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00442391
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20593
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7855
A549_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129421
DAGLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682401
Corpus amylaceum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
GRIN2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778669
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4955
AA-49-BD04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.728882
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9822
Semimembranosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.05975
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
9839_WDR74_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46636
BD-90-DK64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.479955
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.11671
KDM5D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00380669
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.699581
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.00554
BRD-K89219015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10519
GPI-anchor transamidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14254
GBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515116
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7510_RPS20_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00509
BC-86-PL11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209187
BRD-K54558492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43229
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.68074
CRCGN008_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2599
SLC6A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00775075
BRD-K17889110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96751
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330966
9687_UTP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24693
Blue cone monochromacy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
BRD-K61139423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5117
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
YK-4-279	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.03
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNRNPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21415
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	0.967112
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7608835-aba3058_Table_S5.xlsx-RING1B_EWS-FLI1_REPRESSED-RING1B_EWSR1-FLI1_repressed_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.506
496100522_PCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04307
AD-53-VC77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220791
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.648438
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.17018
AA-76-VE74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218819
HARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20263
NDUFS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00462516
10074-G5	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
8061_SLC37A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.590579
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318316
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.97602
4931_MED11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.5691
UMUC16	DepMap CRISPR Gene Dependency	1.0	2.72309
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.686699
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.616567
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5543
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5377
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.900204
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243323
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136648
8670_TAF8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514516
Rat-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
PECAPJ34CLONEC12	DepMap CRISPR Gene Dependency	1.0	2.93039
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5617
GAS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77188
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TOM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18214
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UGT3A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537265
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	64.8417
TDRD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11477
BRD-K81888673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08116
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2688
BRD-K10528627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53728
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32258
TSEN15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46215
Cilengitide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.38
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.67362
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57270624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16543
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-30-DA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243419
EC-89-AJ93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448526
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540836
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	92.7719
FOXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88091
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AMY2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570681
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2782
BRD-K31483891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21633
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.704
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222337
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216509
Spongiotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.486
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3307
BRD-K37356599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89468
715_AURKB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.83279
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83627
BRD-K44894536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57917
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB1119	DepMap CRISPR Gene Dependency	1.0	2.10098
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.855888
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14161261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08706
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF846	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05032
KCNN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576208
BRD-K12862541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61822
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90069
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7823
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DETROIT562_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.13859
SDHB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504365
PMC12903452-mmc5.xlsx-ST2-2_OCT4_Off_Targets-Target_Gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
CCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35058
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712718
BRD-K31300534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25704
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26399
BRD-K64602559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40679
BRD-K77820762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00568
BRD-A89554862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28155
BRD-K89767945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02419
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.637
KU812	DepMap CRISPR Gene Dependency	1.0	2.17525
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14524
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04192407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70049
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10951
GPR157	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433987
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:J11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08576
MM485	DepMap CRISPR Gene Dependency	1.0	4.76351
ZNF696	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33655
BRD-K49467822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14141
EPHA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524294
Trophoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47273
BRD-K59919062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17267
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88
Vidofludimus	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
BRD-K92059157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08379
ATG4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12009
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44606
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
LY2584702	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
NPEPPS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745755
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34877
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223994
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238377
DA-40-HO94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.84917
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.809739
BRD-K72531838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6193
HAGH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582195
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49765
BRD-K96239538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18145
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
8438_SRSF7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04045
CRCGN015_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1402
BRD-K44339278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45379
BRD-K43896262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36664
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.223
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.9947
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7492_RPP38_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27622
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GLP1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523963
MCF7_TG101209_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00952103
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51369
SLC2A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0034993
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1639
IRF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057116
BRD-K58844095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00637
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04113
Evacetrapib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213382
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33204113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47754
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64763803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03061
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FADS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713895
GSE121198,GSE129779_3_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21811
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2878
BRD-K59974052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20218
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.727157
BRD-K75703503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12769
USB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069206
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.696
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.811942
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239764
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0729
TCCSUP	DepMap CRISPR Gene Dependency	1.0	2.78607
PB-09-OE00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276933
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3582
EC-41-PH99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201265
BRD-A64091909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24727
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214035
MN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01056
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421198
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77407030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03745
BRD-K48540267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86187
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.196
BRD-K14987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01056
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430157
BRD-K44803159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47988
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28287
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-12_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99446825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01721
GSE185519_6_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10123_ZIC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.986097
BRD-K63134971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00499
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45466
BRD-K86467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08383
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-07-NI91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238493
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19965080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99327
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	95.9687
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.953056
DPY30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39302
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ND-68-CU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217911
Momelotinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.39
DC-84-GJ21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221858
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83941
BRD-K36671795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29087
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1262
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17933
BRD-K05561348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12704
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKMEL30_SKIN	CCLE Cell Line Proteomics	1.0	2.07264
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-64-HC34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261026
496100493_TCx_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06361
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610722
cal39	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.369
IL23R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727693
BRD-A05422420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87181
GSE114284_4_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82638914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11937
Glycyrrhizic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.692319
BRD-K97485956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07671
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08829593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1694
LD-47-RN92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433973
FD-48-HZ39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252116
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.910869
TE4	DepMap CRISPR Gene Dependency	1.0	2.21383
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.47583
BRD-K86448296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04074
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28379
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.093
4152_INTS7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32572
CEP43	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587292
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.84663
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.840759
AD-66-NO48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269339
HOXC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1646
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441234
BRD-K66248685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09998
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAPK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00405622
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79051
OSBPL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06048
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cellulose synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.252
BRD-K65203256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4342
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04479
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.038
GSE234514,GSE234516_2_v_0_mitf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53901855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66563
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48746
1489_CENPP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01815
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243708
BRD-K61259788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02851
CHRNE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469566
DRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053381
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351948
BRD-K26704304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2816
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	84.8831
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488007
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278311
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353123
DB-24-CQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325849
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11732233-mmc1.pdf-327-GTF2IP4_GTF2I_P1_GTF2I_GTF2I	Rummagene Transcription Factor Associations 2026	1.0	null
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
2125_DDX49_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21815
ELP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05561
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4538
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.47156
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.995338
KMS-11/TKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.355
BRD-K19168437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16312
BRD-K00950228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69933
1605_CHTF8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26281
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DF-95-CY55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448698
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1381_CD99L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507266
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.887
BRD-K94993773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21554
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	1.79782
Subpellicular microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
ETNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538861
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2091
BRD-K75073374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26783
PLCE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517575
CRCGN015_MCF10A_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1065
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25877713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76132
IB-94-WM88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220613
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.7668
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
5598_NELFA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01641
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9048
BRD-K14589361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51572
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Molybdopterin synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.402
TAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21227
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580298
BD-69-XG81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47689
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02511
HS944T	DepMap CRISPR Gene Dependency	1.0	2.31763
3381_GKAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534515
8594_SUPT16H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58116
MPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13273
Benethamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.83
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24209
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3887
GSTO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540823
PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
HUPT3_PANCREAS	CCLE Cell Line Proteomics	1.0	6.21053
BRD-K86995890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16993
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JB-28-VO37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508859
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB415	DepMap CRISPR Gene Dependency	1.0	2.86223
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00507913
PPAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642485
BRD-K30117087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21101
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EPHA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575926
TUBE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00411167
CRCGN015_MCF10A_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53551
BRD-K77609086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56378
10442_ZNF554_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548064
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37869
NKX2-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12046
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85697068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32944
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	80.3861
Junctional zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZDHHC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01206
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.01538
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62215
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249303
2102_DDX10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08344
BRD-K89863047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50003
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.501131
UPCISCC026	DepMap CRISPR Gene Dependency	1.0	2.87712
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15874
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25496
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71204648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97486
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0446
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Tafamidis	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
Cervical intraepithelial neoplasia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
BRD-K10435664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04364
BRD-K59006776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19478
BRD-K66089377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36203
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.634246
SMAD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610517
BRD-K51858914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01642
AB-85-JR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584913
BRD-K81537454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10765
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882419
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.548198
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7541
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DA-67-HS65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268275
GSE212760_0_v_1_fxr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91843292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69602
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01522
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.21081
BRD-A67697194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73723
BRD-K92365616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02949
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K46639367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03989
CRCGN015_HEPG2_48H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1453
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.69312
ED-83-GF49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281102
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3286
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.706263
BRD-K72183943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11302
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44732
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
ZC3H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20555
FXYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00720716
CHRNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523663
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049253
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57651
DYNC1I2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21475
HY-50713	DeepCoverMOA Drug Mechanisms of Action	1.0	1.05
SUDHL10	DepMap CRISPR Gene Dependency	1.0	7.56425
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2355
BRD-K86867503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48123
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36761
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
kb NB 142-70	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.77
ATP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47339
BRD-K62976536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54923
BRD-A27422067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94204
BRD-K56879482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11551
BRD-K72792753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19819
PMC5732738-oncotarget-08-103415-s002.xlsx-MFC-7_DEGs-Genes_with_significantly_different_expression_between_parental_MCF-7_and_GATA3_WT_clones_with_adjusted_P_value_0_05_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25734
BRD-K84239940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31905
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266174
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11966
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0573
BRD-K70276322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50468
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.952865
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	77.798
GA-28-SS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28333
CTSA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063258
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.742961
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24758
HINT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603887
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10552
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.984835
BRD-K59851511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31936
DB-73-BC12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23301
RB-55-KL42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515252
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581773
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65066
1-EBIO	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13633
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
6521_POLE2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.5716
WDR12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679203
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PAOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22331
6135_PCNA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15162
BRD-A88461048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4552
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
LS513	DepMap CRISPR Gene Dependency	1.0	2.15496
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.74266
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.552627
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
DRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00423961
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4244
GABRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00844702
ZNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7403
BRD-K96778009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24971
BRD-K16739515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47856
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305056
Sporocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
YKG1	DepMap CRISPR Gene Dependency	1.0	2.75801
PCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658393
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
OPM2	DepMap CRISPR Gene Dependency	1.0	3.50904
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65733046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39104
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	68.074
PLCG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585107
PMC4664757-mmc3.xlsx-RX-Indian_RAX	Rummagene Transcription Factor Associations 2026	1.0	null
Mycolate outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
HCC1954_BREAST	CCLE Cell Line Proteomics	1.0	2.84086
BRD-K90163297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60108
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3209
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260065
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252844
BRD-K19227646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00543
NADSYN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565073
DMRTA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7336
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6533_POLR1A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29948
BRD-K50511447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01869
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235569
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
8405_SRFBP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21864
BRD-K05374764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00759
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278695
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3549
PMC4664757-mmc3.xlsx-RX-Chinese_Gene_RAX	Rummagene Transcription Factor Associations 2026	1.0	null
BC-56-BB82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263265
Rhoptry	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04826
BT16	DepMap CRISPR Gene Dependency	1.0	2.25659
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381732
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.453941
BRD-K64091938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21609
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546699
BRD-A46566149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53434
BRD-K03654379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56538
MCF7_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011519
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28376
NF-21-HQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.732612
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.8629
HUNS1	DepMap CRISPR Gene Dependency	1.0	2.26262
BRD-K69453385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51784
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5637
SLC6A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554953
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4735
Cerebral subcortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.68634
1441_CDK7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12444
BRD-K00542622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41785
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98695520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16254
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.0761
BRD-K79555018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08124
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.99017
BRD-K82935855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01891
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.53766
BRD-K88038091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66578
BRD-K76449854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45705
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K01715539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23661
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3927
BRD-K15647573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51415
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.344
Angelman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3527
BRD-K21000135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63444
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317298
BRD-K20501114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06489
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223493
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K35442564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45785
IL6R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565186
NCIH2066_LUNG	CCLE Cell Line Proteomics	1.0	2.01434
BLTP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514699
chrX_135043274_C_G_b38	GTEx eQTL 2025	1.0	1.10985
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6896
NB6	DepMap CRISPR Gene Dependency	1.0	2.23889
MIAPACA2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.13164
GSE233183,GSE233187_2_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63209730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24619
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.71656
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213096
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2519
Isl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0506
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8193
ZC-47-HL31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245366
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4735
JMSU1	DepMap CRISPR Gene Dependency	1.0	2.34516
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.82603
BRD-K29083370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29307
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524968
FBXL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15387
BRD-K06279388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6062
CYB5R3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00659484
BRD-K21671578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17665
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AGS_STOMACH	CCLE Cell Line Proteomics	1.0	6.37115
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB11FIP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00988
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32953
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466788
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	91.8744
PPP1R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07494
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46152990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76266
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_SOX15_CUT_Tag_top_10k_peaks_Related_to_Figure6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64299311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.543
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.31709
BRD-K59522787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25147
SOX13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3379
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-442_common_elements_in_HIF1_peaks_and_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.18918
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACSM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654272
BRD-K77743611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00501
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.32263
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Femoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87290989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31749
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.50919
Juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
BRD-K68890376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22398
GSE182179_2_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66342
CASK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00647878
BRD-K34106082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03375
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.07786
VPREB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701765
pg4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3733
BRD-K21215763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11662
8165_SMG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.549059
GRM8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558591
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
2473_EDARADD_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607594
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07688551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26698
Isotretinoin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.43581
BC-74-QN56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239695
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-83-LN99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245166
CRCGN008_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5743
BRD-K65392756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70056
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.0714
BRD-K63665694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89272
S0-EE-X7LX_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271316
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24079
BRD-K12384030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10469
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265674
BRD-K05796780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32945
BRD-K14570970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64027
NEK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0040079
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.85177
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436179
BRD-K82126187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74982
BRD-A17902629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11312
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6934
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AF-33-HJ54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223343
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614928
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18406
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4218
BRD-K09378334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44017
GSE152441,GSE152442_1_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RF-36-EI47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234173
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89175823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29535
BRD-K62017257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2823
BRD-K54332480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13881
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236205
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	108.747
BRD-K90157100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4509
CHEMBL513147	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.57
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239447
BRD-K28107038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5274
BRD-K75275329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53752
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24822
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08989
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3472
KIR2DL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633251
FCRL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058984
BRD-K34234678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07502
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IA-76-ZU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252983
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.344
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61301
LIVF001-018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18838
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8132
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_down-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73364700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68275
CD-96-HO43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226102
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.9322
BRD-K47049026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75532
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66719
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
UMNSAH/DF-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
BRD-K98731550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41451
WDR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30029
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.30947
115_ACTR3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52979
RB-55-KL42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.397339
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0247
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.956209
BRD-K52372795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49813
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.451093
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7965
RAPGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34984
AA-56-QO38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230283
BRD-K58310485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18781
BRD-K75807319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12593
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.9118
BRD-K89366873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31644
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0966
496100666_HIP_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02659
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373503
TIMM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31944
NPHS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568775
2764_ETV4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.683705
CRCGN014_HEPG2_3H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02539
2-iminoacetate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
PRKAR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583817
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Trophoblast giant cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.306
BRD-K32827537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12348
BA-39-HG26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396255
BRD-K64862097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21531
BRD-K58112932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55658
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259429
OE-75-WF43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204602
BRD-K75135426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38028
CSNK2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10756
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03719
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	60.3311
BRD-K30917841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36928
NF-21-HQ00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299625
TLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34842
BRD-K22683888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67779
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8382
HUWE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09253
BRD-K91137832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45072
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-09-JG96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209573
BRD-K32947579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4971
RVX-208	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
ARPC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00829098
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3651
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19085288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26837
ITGB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00356952
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08028
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712412
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FOLD_CHANGE_1_5_RELB-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4664757-mmc3.xlsx-RX-Chinese_RAX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3572987-pone.0056308.s001.xls-EVI1_regulated_genes-GENE_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28345
BRD-K26272845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7473
ACE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47313
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MF-37-KQ09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206533
GSE255988_2_v_0_ethanol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4664757-mmc3.xlsx-RX-Indian_Gene_RAX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82292504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62934
BRD-K38650960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41407
JAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054701
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4324
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
PLX-4720	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.49
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.8779
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215758
ID-31-PA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21125
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522456
SGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
HUH7	DepMap CRISPR Gene Dependency	1.0	2.4013
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10125
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.748627
BRD-K69536411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23287
BRD-K36575476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81252
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29511
BRD-K62150807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38091
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.783046
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.6385
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31785
6963_PWP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.73705
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ectoplacental cone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.529
AB-85-JR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26205
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2455
BRD-K19962165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05709
BRD-K72932441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6418
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186460_3_v_6_baricitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91060460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91261
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07822
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16496
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parietal trophoblast giant cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.621
GSE158893,GSE158916_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177114
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.841
GSE234514,GSE234516_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63024248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16951
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.594
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	66.5125
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.3927
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.70995
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45782
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69123
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42037
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8087
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393906
LEF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516211
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.2191
RNF225	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04006
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	68.9445
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5664
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23316938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.103
9226_TRAF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.640685
JE-22-JR20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438249
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14909006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0053
TMEM179B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5219
BRD-K47275094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51977
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
ko143	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
BRD-K75281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63627
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77965546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11696
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3014
CAKI1	DepMap CRISPR Gene Dependency	1.0	4.67183
ICC4	DepMap CRISPR Gene Dependency	1.0	2.21555
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2041
BRD-K43909206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76021
BRD-K29366596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2324
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.60618
837_BIRC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28091
YF-77-FV50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248127
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.426
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.588573
BD-63-KJ69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207938
CRCGN015_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3716
ZBTB38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12661
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0753
BRD-K43484052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0896
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2619
LHX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2231
BRD-K64753899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0365
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-13-DN24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383973
NMRAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26203
CRCGN009_HEPG2_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01376
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.879413
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
GRB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28758
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296893
COL9A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0896
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394287
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10199266-mmc2.xlsx-RUNX1-DEGs-Unnamed_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37168
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54278059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18545
VMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727215
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.13041
SLC45A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00413218
PLXNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045933
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77663497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04274
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4183
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.932316
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.1667
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.98629
BRD-K39222068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35831
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.7793
BRD-K86155400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22247
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.985588
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450195
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	118.392
BRD-K76482408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97259
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF618	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05804
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K52123365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07314
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
IRF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582435
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51646
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
PGRMC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00415136
GATD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19439
Epoxomicin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.21
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26733
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	95.1584
10703_ZNRD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31367
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543904
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CALB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658194
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258718
IB-56-JN40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208545
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6982
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2052	DepMap CRISPR Gene Dependency	1.0	2.74464
JVE015	DepMap CRISPR Gene Dependency	1.0	2.37959
496100569_TCx_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14858
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57795803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53527
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.19389
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08871
GSE151612_0_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78438852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4674
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227094
DB-18-UF01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411412
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45519
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208728
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513106
P4HA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583726
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52713598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32927
6396_PKM_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.823362
BRD-K85646123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1083
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.615324
BRD-A71933035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37612
GSE240468_3_v_2_nfyc_human	RummaGEO Gene Perturbation Signatures	1.0	null
5339_MTOR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545556
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.8975
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6863
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233932
A2M	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651307
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146687_2_v_3_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3029
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439427
SLC19A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00494904
ZB-16-BR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468817
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27265
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07762528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91344
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	144.345
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279216
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6205
COLO800	DepMap CRISPR Gene Dependency	1.0	5.47389
PRKN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00660775
CB-92-VC05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231212
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62964360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30351
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	121.182
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.16333
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.41457
GLI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678169
BRD-K72255288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62375
BRD-K18737347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20051
BRD-K45936761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49251
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PATZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35083
CHLA10	DepMap CRISPR Gene Dependency	1.0	2.5946
PROCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11131
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01038
Twist2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.7789
NEK10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522541
FU97	DepMap CRISPR Gene Dependency	1.0	3.68931
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7522
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28483
PMC11297914-41389_2024_531_MOESM1_ESM.pdf-129-HIVEP2_HIVEP2	Rummagene Transcription Factor Associations 2026	1.0	null
LD-69-TV81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202154
BRD-K23870105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09143
JE-22-JR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237566
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404409
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40903
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.14906
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.708
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3962
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.91763
BRD-K03770502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35109
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bromopyruvic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51983
PFKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01372
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218098,GSE218099_1_v_0_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	2.72419
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
2580_EIF6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04678
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78359
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396742
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37768
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8065
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17922
BRD-K65602491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77688
BRD-K50498614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0898
IA-76-ZU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280779
10924_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519371
POLR3H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505681
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79423
CCNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1234
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61846
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15196
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.23786
GSE233679_6_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64577556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03936
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21588993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01303
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1566
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.528987
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0914
PLD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601607
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.49063
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0435
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_8_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635898
HAL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550485
BRD-K00717406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44005
BRD-K71486446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46016
ARHGAP45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08243
8_AAMP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.276
FTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39213
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5255
EF-01-LB20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.704561
BRD-K87872414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35542
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8761
BRD-K41451401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93355
PMC10679653-mmc4.xlsx-ISL1_KO_Markers_T_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.22438
Microneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
NCIH1666_LUNG	CCLE Cell Line Proteomics	1.0	4.99007
AMMECR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45243
BRD-K56661847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15311
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06926365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25137
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8726
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7197
MDFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26192
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12867546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32514
BRD-K01853388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50196
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348919
OB-78-PA58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222542
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472621
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.707467
BRD-K53624506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35916
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52695
BD-69-XG81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359105
Kagami-Ogata syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4466
BRD-K83684822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41128
4153_INTS8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12256
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52741
BRD-K90294313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40024
496100513_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36385
BRD-K90408478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1378
BRD-K90325960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04117
IDI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718271
Temple syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
BRD-K72681425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21164
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ISG20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01854
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315431
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32762
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
JEG3	DepMap CRISPR Gene Dependency	1.0	3.50987
GSE203017_0_v_1_irs2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVMIU	DepMap CRISPR Gene Dependency	1.0	5.65364
BRD-K06725890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49891
BRD-K57879743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29294
BRD-K21771449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29842
BRD-K14451397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45527
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.08183
BRD-K63547380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32067
PMC10679653-mmc2.xlsx-ISL1_KO_Markers_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
1470_CEBPZ_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15631
BRD-K40745976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1732
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0254
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377819
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77267
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
AA-67-TF79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240666
ADCY5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060236
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07062
ARF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497806
SNRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571825
BRD-K12325488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07019
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13248
BRD-K53639581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82786
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.776955
BRD-K04791118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06333
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48551
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49529874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39709
BRD-K88881681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28738
CRCGN008_HEPG2_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1401
GSE179868,GSE180330_1_v_0_ddx21_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08501
BRD-K95323025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28611
AA-45-AA67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215941
BRD-K83895653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16816
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FUT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477022
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RD-79-FH72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331129
BRD-K66216147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47486
BRD-K15099225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01247
WEE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0039491
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.720661
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44328
ATP6V1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12517
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23927
BRD-K05087650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11088
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559692
BIRC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675766
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.69587
PPP3CA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691506
FMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637808
PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.81026
ACTR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18468
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307045
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.649
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XC-61-SE50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215815
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
9938_YKT6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19821
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.0311
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.559665
BRD-K52468958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42701
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31490008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33986
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597268
BRD-K70315531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15295
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.8337
TSSK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22688
BRD-K61551386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41854
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.99874
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.01069
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273252
PMC6917500-elife-47110-supp1.xlsx-Table_J-Table_J_Differential_gene_expression_of_S-phase_invasion_cells_and_the_cells_treated_with_DMSO_SKI-73_and_SKI-73N_SKI	Rummagene Transcription Factor Associations 2026	1.0	null
LRRC75A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42719
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.39475
BRD-K05181466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60331
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218877
HEYA8_OVARY	CCLE Cell Line Proteomics	1.0	2.4006
AC-33-YJ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32434
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1187
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457694
4716_LUC7L3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37408
CRCGN014_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11665
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19983
IGLL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0041162
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265571
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06267
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305925
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.932287
HIF1AN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631041
NEK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497427
CYB5D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79493
RAB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01744
BRD-K67229323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24831
RNF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11022
BRD-K53396471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12362
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600985
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64728664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06014
ANXA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00391657
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GALE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497318
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9804_WDR12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00546
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
TCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31123
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22239
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.0476
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418061
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378174
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248332
CDK15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055657
Sporulated oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.68
TIRAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647587
Cecal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.433
CHRNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493427
BRD-K84606053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45365
DB-88-VW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.431119
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.6048
1129_SPOUT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05666
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.83251
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218543
DNAJB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00696621
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38450726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52888
BRD-K79807180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43411
BRD-K59069382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78779
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.00356
BRD-K11625057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04649
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.59095
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223273
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	60.6018
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1197
MRPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52912
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.18999
1212_CAST_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542017
BRD-K19516614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26375
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05342
BRD-K98224452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36506
BRD-A90249268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19315
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75224334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12656
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.64461
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552934
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7965
BRD-K85722200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06933
Leiomyosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
BRD-K18296708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39933
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11474067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01643
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468573
759_BANP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09157
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30816
CRLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30339
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204101
9444_TWSG1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02679
BRD-K79604175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31264
NIPAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86076
BRD-K32418104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1605
DHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00348943
BRD-K74445272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1615
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.635
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EXOSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04569
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.55966
7444_RPL19_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39784
PMC7021759-41467_2020_14682_MOESM10_ESM.xlsx-downregulated_genes-Table_S7_Dowregulated_genes_in_SKNMM_and_U2OS_cells_with_MYCN_induction_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
FB-85-ND09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267175
BRD-K70819166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14066
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K52473019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25767
SLC6A12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745994
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1993
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218668
Sporozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
CYP11A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725824
SMAD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5615
BRD-K88590066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20371
BRD-K31616862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46332
APLNR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557171
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426218
CRCGN017_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0356
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EPS15L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07594
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00514
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.33386
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508828
BRD-K95761590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11758
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27865
BRD-K87990170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34443
BRD-K91297952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88031
CSDC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502638
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
IL16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643088
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241634
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6165
BRD-K54538111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07933
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267286
Sulforaphane	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
RETSAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656174
BRD-K48710089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12008
BRD-K46082763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04652
AA-39-BD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300085
CCDC59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48521
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309116
BRD-K77272277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14606
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251902
KC-26-JQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217957
Thyroid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.84125
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294676
IGR1_SKIN	CCLE Cell Line Proteomics	1.0	3.8589
OCILY19	DepMap CRISPR Gene Dependency	1.0	3.30553
TSPAN9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551079
CB-24-FA25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30669
ZNF347	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10076
CYP4A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668836
SNU182	DepMap CRISPR Gene Dependency	1.0	2.47235
CA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677902
BRD-K69132276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61407
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K48670593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06156
MCF7_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143607
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213441
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77655
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602599
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.201
EB-67-WB79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324813
Ibrutinib2	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13901498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46897
PSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32921
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144453,GSE144454_1_v_0_tfdp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DSTYK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005094
BRD-K40750649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38807
GIPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33993
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.913
BRD-K92913380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53113
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10592962-media-4.xlsx-OC2_genes-gene_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
QF-45-KI95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247648
ZNF839	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22108
Forelimb muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
PRDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54056
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0572
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85649685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02951
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.2609
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22775
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65571
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.5064
BRD-K39913853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01359
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.551127
JMJD1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99223
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56573
BRD-K91419355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34096
BRD-K97946004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39135
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.7286
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1825
CDK11B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579687
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.3115
STAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490155
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533132
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.4529
MGP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108773
CNTN5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521851
5127_MMS22L_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38785
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-98-MW52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283064
CERS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491127
DD-54-MA35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222318
NSDHL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00374809
ARIH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495943
AB-25-XU75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426857
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Atf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6712
SPC25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576344
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44627
7188_RBMX_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05756
CBX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00446329
BRD-K16357911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99106
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2964
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GPRC5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403788
PDILT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577921
BRD-K69248736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06562
PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-E_MYOG_binding_in_downreg-Unnamed_1_MYOG	Rummagene Transcription Factor Associations 2026	1.0	null
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0305
NB-17-SQ59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305545
PMC4695334-mmc3.xls-HCC_SMAD3_DNA_Me-Unnamed_2_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60694
496100552_PCx_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27329
GPR82	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00651369
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.15894
AS 1517499	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.18
KDM5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609307
AKT1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95973
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CFB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689963
INO80E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39318
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
INTS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12907
NCIH2882	DepMap CRISPR Gene Dependency	1.0	2.3065
KAT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81787
GSE205556_1_v_0_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75606012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44512
NR4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639646
PMC8851354-Table_2.xlsx-Genes_reg_by_FUS-DDIT3-Supplementary_Table_2_Genes_significantly_regulated_by_FUS-DDIT3_expression_in_HT1080_cells_adjusted_p-value_0_05_and_log2_Fold_change_1_or_-1_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5131
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03473
BRD-K90741031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00073
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
9400_TTK_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00602
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.716644
CC-50-FK24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250845
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.583902
EFHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00559236
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.5149
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269338
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	99.2686
ZDHHC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25983
PLTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605381
BRD-K08300592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92704
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26409
HNRNPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52825
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38239
BRD-K04067194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4387
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34293
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291902
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.674
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
TRPC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511128
Conoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.825
LTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21445
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75980238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25313
PRKAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24341
BRD-A17741195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88623
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279472
BRD-K50005301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02271
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4911
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91007808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00734
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13782363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52468
BRD-K86578973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10032
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326254
WEE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644476
BRD-K03923461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22649
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551394
CB-11-GB40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204037
BRD-K32759631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15543
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274377
TYKNU_OVARY	CCLE Cell Line Proteomics	1.0	5.49334
MMP19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00763152
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.756173
Cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.868
CAL78	DepMap CRISPR Gene Dependency	1.0	2.20827
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.861862
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.560099
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485908
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.51995
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476118
BRD-K12271646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58355
BRD-K43336921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7778
BRD-A06471483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44065
BRD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564971
HCC56_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.39637
TFRC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519846
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.505572
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.693
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.97993
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60115
BRD-K81725246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23891
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	1.0	null
VAESBJ	DepMap CRISPR Gene Dependency	1.0	3.08964
BRD-K89637567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87391
BRD-K73114074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09552
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
D425	DepMap CRISPR Gene Dependency	1.0	4.0105