association dataset threshold value standardized value lateral anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60095 SRY-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.59766 MAPACHS77 DepMap CRISPR Gene Dependency 1.0 3.45171 GSE158834_11_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null SNU1079 DepMap CRISPR Gene Dependency 1.0 4.15226 YD8 DepMap CRISPR Gene Dependency 1.0 3.21966 NCI-H1781 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 BRCA1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE200839,GSE233826_3_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R3RS-0126-SM-3GIJL GTEx Tissue Sample Gene Expression Profiles 1.0 0.871643 PMC12882559-12894_2026_2046_MOESM2_ESM.docx-0-ZNF770_ZNF770 Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02798 GTEX-UJMC-0926-SM-4IHLK GTEx Tissue Sample Gene Expression Profiles 1.0 1.18555 Lung squamous cell carcinoma_LUSC_TCGA-79-5596-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.826994 Supramammillary nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06331 BL41 CCLE Cell Line Gene CNV Profiles 1.0 1.41687 KLHL40 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P78B-0726-SM-2S1O2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892777 PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null MARK4 Pathway Commons Protein-Protein Interactions 1.0 null FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.01203 JUN ENCODE Transcription Factor Targets 1.0 null LB771HNC DepMap CRISPR Gene Dependency 1.0 3.17836 C4I DepMap CRISPR Gene Dependency 1.0 5.14115 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.260792 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91691 TUBA1C Pathway Commons Protein-Protein Interactions 1.0 null Desmosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.873 Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05723 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39788 SMG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43924 PRKCA Pathway Commons Protein-Protein Interactions 1.0 null H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCL22 CCLE Cell Line Gene Expression Profiles -1.0 -1.49818 EGR1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0126-SM-3NMC2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.903198 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72591 hsa-miR-3183 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.39997 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07317 GSE135514_2_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null HSP90AB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_11_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE151612_4_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Hemidesmosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.113 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14174 COLO680N CCLE Cell Line Gene CNV Profiles -1.0 -1.33319 GNL3 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_SRT1720 HCl_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145255 ULK3 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 ELF5-23300383-T47D-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS6KA3 Pathway Commons Protein-Protein Interactions 1.0 null LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 NCI-H1355 COSMIC Cell Line Gene Mutation Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24279 intermediate stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44517 PER2 Pathway Commons Protein-Protein Interactions 1.0 null NA-30-HS87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.808186 GSE144453,GSE144454_1_v_0_tfdp1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QV31-1626-SM-2S1QC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887342 RH-41 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.99545 sporangium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.124152 Dental pulp TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.642 WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.934874 BV173 CCLE Cell Line Gene CNV Profiles 1.0 2.09417 FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.975543 FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.48873 CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE208171_0_v_1_zc4h2_human RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112762,GSE112767_2_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE161295_0_v_5_cdk8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE150055_0_v_1_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5 ENCODE Transcription Factor Targets 1.0 null CDC37 Pathway Commons Protein-Protein Interactions 1.0 null GSE158715_2_v_4_cyp1b1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01986 H3K4me1_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAPK14 Pathway Commons Protein-Protein Interactions 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4933 SIK3 Pathway Commons Protein-Protein Interactions 1.0 null Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.446 RPS2 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.08033 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44191 GSE211931_0_v_3_ncoa4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE169356_0_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.630314 TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 147.089 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16069 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5827 contributes GeneRIF Biological Term Annotations 1.0 null Perturb_13920_KD_HNRNPK_SRP312616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 CHD2 ENCODE Transcription Factor Targets 1.0 null GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9011 GSE134375_4_v_2_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null inflorescence TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060265 A549_Prednisone_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151161 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null t30-blood-rna_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.80816 SKGT4 DepMap CRISPR Gene Dependency 1.0 2.25287 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.2229 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Oculodentodigital dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.393 GTEX-NPJ8-1926-SM-3MJGB GTEx Tissue Sample Gene Expression Profiles 1.0 1.40484 medial part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41802 GTEX-WFON-0826-SM-4LVMI GTEx Tissue Sample Gene Expression Profiles 1.0 1.27464 Perturb_6505_KO_PTEN_SRP299373 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.97527 TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 141.872 HNF4G ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_3739_KO_Gna13_ERP130528 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.95797 GSE123887,GSE123888_2_v_1_hpgd_mouse RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.93518 XRN2 ChEA Transcription Factor Targets 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.969128 GTEX-XQ3S-1126-SM-4BOPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.4898 DFFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14831 UNC45A Pathway Commons Protein-Protein Interactions 1.0 null MELK Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Mercaptopurine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139722 GSE158834_0_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null mandibular incisor TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.85547 ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8933 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JOPACA1 DepMap CRISPR Gene Dependency 1.0 3.39539 GTEX-XPVG-2126-SM-4B667 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848386 GTEX-POYW-1126-SM-48TCI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18879 Anal sac TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.59 Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X2-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZEB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-2126-SM-3GILK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70507 GSE217552_3_v_4_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null VA-48-RJ44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.90669 SNU245 CCLE Cell Line Gene Expression Profiles 1.0 1.68366 gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.99697 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73243 protein-lipid complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.109376 TFIP11 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_2870_Mut_KEAP1_SRP404927 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC8321895-41375_2020_779_MOESM4_ESM.xlsx-marker_genes-TAL2_TAL2 Rummagene Transcription Factor Associations 2026 1.0 null SW1990 DepMap CRISPR Gene Dependency 1.0 2.43128 ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.771 microbody LOCATE Predicted Protein Localization Annotations 1.0 null non-invasive bladder urothelial carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.927 MZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.951788 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BD-46-RY02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.225174 GSE210682_2_v_3_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V3-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRK-1326-SM-3NB1A GTEx Tissue Sample Gene Expression Profiles 1.0 1.10335 CAD Pathway Commons Protein-Protein Interactions 1.0 null ZSCAN18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18588 cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7M4-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.629242 MCF12A Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.795534 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.94556 PHKG2 Kinase Library Serine Threonine Kinome Atlas 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855432 Periodontium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.54 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.15492 H2BK12ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HT-144 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1948 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93892 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041856 PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.060891 exon GeneRIF Biological Term Annotations 1.0 null Integument TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.048 HDAC2 ENCODE Transcription Factor Targets 1.0 null GSE158834_11_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null YE-80-LN04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.244521 KMS18 CCLE Cell Line Gene Expression Profiles -1.0 -1.83265 Lung squamous cell carcinoma_LUSC_TCGA-98-8020-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHKG1 Kinase Library Serine Threonine Kinome Atlas 1.0 null RPS4X Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Capecitabine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0206841 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0126-SM-4B66N GTEx Tissue Sample Gene Expression Profiles 1.0 0.98422 GTEX-RM2N-0726-SM-48FD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10034 Mouth disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.970723 GSE218819_2_v_1_kdm5b_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JE-04-LS32_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244454 MCF7_Tozasertib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151911 CREM ChEA Transcription Factor Targets 1.0 null QE-00-EB96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.209306 GSE181003_3_v_2_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null GSE119978,GSE180930_2_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null r10 part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09341 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 JASPAR Predicted Transcription Factor Targets 1.0 null TWNK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40519 PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null presented GeneRIF Biological Term Annotations 1.0 null XIRP1 Pathway Commons Protein-Protein Interactions 1.0 null superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.87516 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35307 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.62996 CCNT2 ENCODE Transcription Factor Targets 1.0 null GSE200839,GSE233826_5_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XV7Q-2426-SM-4BRV8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.86053 hsa-miR-4757-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE147662_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE199204,GSE211619_4_v_1_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null OB-17-DQ74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.302745 GSE224877_2_v_1_pctp_mouse RummaGEO Gene Perturbation Signatures -1.0 null EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE233647_2_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.261 CTNNA1 Pathway Commons Protein-Protein Interactions 1.0 null gastrointestinal system disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FD-62-ZB67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.319547 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0253 RPS15A Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175571_3_v_2_acsl6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.348 NOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.08746 MCF7_Celecoxib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139403 TNK1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18277965-TableS1a GeneSigDB Published Gene Signatures 1.0 null ADAM22 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-DX-A240-01A-32R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_2_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_7868_KD_NEK2_SRP256251 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -12.2998 GSE131649_2_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FI-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23513 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.948243 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCI38 DepMap CRISPR Gene Dependency 1.0 2.19062 GSE88819_11_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE151612_4_v_11_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.954901 SW1783 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.09282 CC-03-PW00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.264799 MKN1 CCLE Cell Line Gene CNV Profiles 1.0 1.33944 ZMAT5 Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2710-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Eccrine sweat gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.565 SMARCA4-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE158632_3_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null TLE2_02_53 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58929 GSE222758_0_v_4_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE206870,GSE206872_4_v_5_ascl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 colonrectum_d HPA Tissue Sample Gene Expression Profiles 1.0 0.845241 EIF3I Pathway Commons Protein-Protein Interactions 1.0 null PCM1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PSDG-0526-SM-2S1OH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88001 MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.73571 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number MGI Mouse Phenotype Associations 2023 1.0 null GSE238018_3_v_4_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null GSE196671_6_v_8_obox4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RV-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE116810_2_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8452624-41467_2021_25709_MOESM12_ESM.xlsx-ST12-Unnamed_2_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null MZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33398 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.357 TKT Pathway Commons Protein-Protein Interactions 1.0 null GSE205976,GSE205978_3_v_5_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.9605 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null ZBTB39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47724 GSE195559_6_v_5_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K36me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-0926-SM-3TW8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.32031 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93892 NCIH2087 DepMap CRISPR Gene Dependency 1.0 2.44275 MYC_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZH-0926-SM-4DXU4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.957219 GTEX-X585-1226-SM-46MW7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09499 male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 small heart MGI Mouse Phenotype Associations 2023 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4141 GTEX-OIZH-0126-SM-2HMIS GTEx Tissue Sample Gene Expression Profiles 1.0 0.947831 VZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.873612 Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.07013 misalignment of teeth HPO Gene-Disease Associations 1.0 null r9 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.13219 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.77838 GTEX-XBED-2226-SM-47JYQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.899605 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.21303 protein localization to organelle GO Biological Process Annotations 2025 1.0 null H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE88819_0_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Iniparib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178149 PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8 Rummagene Transcription Factor Associations 2026 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02186 GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06581 GSE158197_0_v_11_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer CP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15085 superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47158 IKZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.722 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8616-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE121824,GSE121826_0_v_8_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null ASL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04938 EE-03-SG02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.32078 unreported GeneRIF Biological Term Annotations 1.0 null Keratosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.149 KRT2 Pathway Commons Protein-Protein Interactions 1.0 null GSE148200_1_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EIF3B Pathway Commons Protein-Protein Interactions 1.0 null STUB1 Pathway Commons Protein-Protein Interactions 1.0 null 16288205-GeneTable3 GeneSigDB Published Gene Signatures 1.0 null CTCF-21964334-BJAB-B-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null recruitment GeneRIF Biological Term Annotations 1.0 null H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151412_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE185139_1_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null TMEM263 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79359 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.952605 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE182179_5_v_4_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null GSE134029_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null 23132-87 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.99967 CGTH-W-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.07659 KB-78-BE93_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.503817 Renal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 SC-596 (CCNA2) NURSA Protein Complexes 1.0 null GSE199255,GSE199356_3_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE61117_0_v_1_trim24_mouse RummaGEO Gene Perturbation Signatures -1.0 null testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE138741,GSE138743_0_v_1_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R53T-1126-SM-48FD4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07415 E2F4 ENCODE Transcription Factor Targets 1.0 null hsa-miR-455-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13488 GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06676 vesicles GeneRIF Biological Term Annotations 1.0 null superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20398 amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.69384 EEF1G Pathway Commons Protein-Protein Interactions 1.0 null 20380719-TableS5 GeneSigDB Published Gene Signatures 1.0 null inner SZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34109 PPIA Pathway Commons Protein-Protein Interactions 1.0 null GSE74528_0_v_1_trex2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CC-68-YZ44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.312202 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-24-KQ98_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200138 CTCFL_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923461 FAM110A Pathway Commons Protein-Protein Interactions 1.0 null 19286929-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GSE199660_1_v_0_secretin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-A6UG-01A-32R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S341-0526-SM-4AD5U GTEx Tissue Sample Gene Expression Profiles 1.0 1.24628 TGBC18TKB DepMap CRISPR Gene Dependency 1.0 6.09108 GSE174498,GSE174500_3_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null JA-79-II25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206186 SIN3A ENCODE Transcription Factor Targets 1.0 null GSE134375_3_v_7_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null SOX9 ChEA Transcription Factor Targets 1.0 null diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.398216 intermediate filament GO Cellular Component Annotations 2025 1.0 null gastroenteritis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.296211 RAGE_knockout_268_GDS3755 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.47644 GSE199644_3_v_1_palmitic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.110721 HNRNPF Pathway Commons Protein-Protein Interactions 1.0 null r3 pontine raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34794 GTEX-WH7G-2026-SM-3NMBL GTEx Tissue Sample Gene Expression Profiles 1.0 1.00107 GSE174701_1_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null ovary HPA Tissue Gene Expression Profiles -1.0 -1.39855 G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03416 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.63627 medulloblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.175679 RCH-ACV COSMIC Cell Line Gene Mutation Profiles 1.0 null PPP5C Pathway Commons Protein-Protein Interactions 1.0 null COPB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20196 GTEX-OIZH-0626-SM-3NB1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.39447 SIK2 Pathway Commons Protein-Protein Interactions 1.0 null GSE122101,GSE122103_3_v_4_ssu72_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2E Pathway Commons Protein-Protein Interactions 1.0 null r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.26031 MCF7_Fedratinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136447 GSE206516,GSE206518_5_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CTCF_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39292 GSE211128_4_v_1_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null DRAK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null GTEX-V955-2626-SM-3NM9F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37874 GTEX-PLZ4-1326-SM-2S1O7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49167 COPB1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R45C-1226-SM-48FEE GTEx Tissue Sample Gene Expression Profiles 1.0 1.18278 ACTL6A Pathway Commons Protein-Protein Interactions 1.0 null Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE9375 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.39729 having GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AH-0826-SM-48TZN GTEx Tissue Sample Gene Expression Profiles 1.0 1.27082 ZBTB7A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADGRB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27346 PMC5013636-ncomms12601-s5.xlsx-LEF1-Groups_LEF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_0_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13442 Bone marrow cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-1426-SM-447AC GTEx Tissue Sample Gene Expression Profiles 1.0 1.36504 GTEX-QESD-1426-SM-2S1R9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.996094 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE128844_0_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13379_OE_SFRP2_SRP115559 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.46911 SPIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45984 r9 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36525 CTCF_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.833149 BUB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62901 CBC802 () NURSA Protein Complexes 1.0 null GSE247775_1_v_0_tmprss2_mouse RummaGEO Gene Perturbation Signatures -1.0 null hemolytic anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.353027 RPS28 Pathway Commons Protein-Protein Interactions 1.0 null superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77871 autosomal GeneRIF Biological Term Annotations 1.0 null skin_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.88144 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14322 FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346411 superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06584 sparse hair MGI Mouse Phenotype Associations 2023 1.0 null periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20948 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.326 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19366 KYSE410_OESOPHAGUS CCLE Cell Line Proteomics 1.0 4.41322 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.911054 Perturb_6127_KO_NEUROD1_SRP170936 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.81691 EPRS Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37357 MCF7_Givinostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165559 esr1_21713035_mcf7_lof_human_gpl570_gds4061 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.52808 Rosette leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.653 GSE201309_5_v_8_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902542 Dental pulp calcification DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.724 GTEX-WYVS-1626-SM-3NM9R GTEx Tissue Sample Gene Expression Profiles 1.0 0.856835 Perturb_15233_KO_Nm1_SRP212300 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.6033 E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.061 A549_Tofacitinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0121087 A549_Cediranib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0116446 cterminal GeneRIF Biological Term Annotations 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_GSK J1_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167325 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE164874_5_v_9_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_MEL cell line_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUP Pathway Commons Protein-Protein Interactions 1.0 null DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.08149 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MLK2 Kinase Library Serine Threonine Kinome Atlas 1.0 null corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.830245 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NR2C2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYJK-0426-SM-3NM9G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927107 TUBB4B Pathway Commons Protein-Protein Interactions 1.0 null ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.51146 SREBF1 ENCODE Transcription Factor Targets 1.0 null GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32319 OC-314 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.56836 pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53623 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.979578 GTEX-RTLS-1126-SM-46MUQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.976777 GTEX-P4QT-0126-SM-2I3FL GTEx Tissue Sample Gene Expression Profiles 1.0 1.3401 A549_Carmofur_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106596 WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.16129 BE-31-XV38_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.871894 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-28-SS67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.308153 BTK_KO_GDS1346_302_mouse_splenic B cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03155 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.516 Fetal Lung Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.1335 GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.36029 G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.907782 GSE242083,GSE242098_2_v_5_med1_human RummaGEO Gene Perturbation Signatures -1.0 null DNM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18047 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.834847 CE-23-HP88_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220478 ludlu1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.737 MHH-ES-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null SF3B4 Pathway Commons Protein-Protein Interactions 1.0 null BCAP31 Pathway Commons Protein-Protein Interactions 1.0 null CRY2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U3ZH-0626-SM-4DXT3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885596 ELF1 ENCODE Transcription Factor Targets 1.0 null Down Syndrome_Fetus_GSE10758 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.50416 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93892 caused GeneRIF Biological Term Annotations 1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 GSE195559_6_v_9_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_7225_KO_CDK19_SRP271652 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.48635 GTEX-V955-1126-SM-4JBH3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16293 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08104 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930906 GSE109140_0_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE116810_5_v_1_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.400314 WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.439282 Nuclear speck COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.686 HSC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null RPL8 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null HNRNPK Pathway Commons Protein-Protein Interactions 1.0 null GSE108084_3_v_2_epinephrine_human RummaGEO Drug Perturbation Signatures 1.0 null PC-18-VX23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221323 mouth disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null HDAC6 Pathway Commons Protein-Protein Interactions 1.0 null AURKA Pathway Commons Protein-Protein Interactions 1.0 null Perturb_7907_KD_ZIP11_SRP363583 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 periventricular stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3746 TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAMSAP2 Pathway Commons Protein-Protein Interactions 1.0 null K562_AICAR_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149016 KAT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34216 PPP2R1A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 JURLMK1 CCLE Cell Line Gene CNV Profiles 1.0 1.40488 GTEX-S4P3-0426-SM-4AD56 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50708 CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042213 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissue development GO Biological Process Annotations 2015 1.0 null calcium metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.125929 PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CACYBP Pathway Commons Protein-Protein Interactions 1.0 null PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null MYBBP1A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPK-1826-SM-2YUMR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970856 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834471 KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.514409 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null heart disease GWASdb SNP-Disease Associations 1.0 0.720744 HNF4A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-6691-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157555,GSE157556_3_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11760944-41598_2025_86694_MOESM1_ESM.pdf-153-JDP2_JDP2 Rummagene Transcription Factor Associations 2026 1.0 null PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE149903_5_v_2_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE255432_7_v_3_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.865494 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933284 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20311 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.09504 RPS23 Pathway Commons Protein-Protein Interactions 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.571 GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null related GeneRIF Biological Term Annotations 1.0 null disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NIP7 Pathway Commons Protein-Protein Interactions 1.0 null GSE60217_1_v_8_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4486 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE163297_0_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OXRN-1726-SM-3NM9B GTEx Tissue Sample Gene Expression Profiles 1.0 1.42038 WC-16-IR43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.426357 ELAVL1 Pathway Commons Protein-Protein Interactions 1.0 null GSE94849_6_v_4_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null apical bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.956428 PCLAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14587 RPSA Pathway Commons Protein-Protein Interactions 1.0 null GSE164757,GSE164759_1_v_0_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null KLF11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 93.2414 AF-30-GH67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273902 LRRFIP2 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_17955_KO_Snca_SRP377748 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.84246 SA-32-CC58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.736965 GTEX-XOTO-0726-SM-4B659 GTEx Tissue Sample Gene Expression Profiles 1.0 0.938081 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937293 NQO2 Pathway Commons Protein-Protein Interactions 1.0 null GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures 1.0 null described GeneRIF Biological Term Annotations 1.0 null UBD Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8140-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA_EP400_22196727 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07938 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.931349 SF3B1 Pathway Commons Protein-Protein Interactions 1.0 null GSE142210_4_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null intermediate stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38088 GTEX-XXEK-1626-SM-4BRUZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.914442 CTV-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.96888 NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_ZM 447439_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139969 GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null FD-62-ZB67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.203811 CE-18-AP15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.8571 Gingival disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.599 KRT73 Pathway Commons Protein-Protein Interactions 1.0 null 496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0888 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF15 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X4XY-1726-SM-46MVO GTEx Tissue Sample Gene Expression Profiles 1.0 1.93684 GTEX-WXYG-2326-SM-4E3I6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02831 PRDX4 Pathway Commons Protein-Protein Interactions 1.0 null EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null ARHGEF17 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SMC2 Pathway Commons Protein-Protein Interactions 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null CHORDC1 Pathway Commons Protein-Protein Interactions 1.0 null JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.634894 PER1 Pathway Commons Protein-Protein Interactions 1.0 null tooth germ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.621831 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AIMP1 Pathway Commons Protein-Protein Interactions 1.0 null PAK6 Kinase Library Serine Threonine Kinome Atlas 1.0 null 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.48781 HDAC1 ENCODE Transcription Factor Targets 1.0 null Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null EEA1 Pathway Commons Protein-Protein Interactions 1.0 null USP9X Pathway Commons Protein-Protein Interactions 1.0 null LMNA Pathway Commons Protein-Protein Interactions 1.0 null 143B CCLE Cell Line Gene Expression Profiles -1.0 -1.87288 ZNF343 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.3627 intermediate stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23217 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.36194 HCC38 CCLE Cell Line Gene CNV Profiles -1.0 -1.70608 GSE133516_5_v_6_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KA-75-LP02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.271335 TMOD3 Pathway Commons Protein-Protein Interactions 1.0 null H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE57871_1_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HCC-15 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.736 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58148 abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.050237 epididymis HPA Tissue Protein Expression Profiles -1.0 -1.00299 GTEX-RWSA-0926-SM-47JXW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941723 DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.98641 NUMA1 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43586 Lung squamous cell carcinoma_LUSC_TCGA-34-A5IX-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE163884_1_v_0_sumo2_human RummaGEO Gene Perturbation Signatures 1.0 null BF-10-IO69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.278467 Amelogenesis imperfecta type 1G DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 PRR14L Pathway Commons Protein-Protein Interactions 1.0 null GSE149854_1_v_0_batf_mouse RummaGEO Gene Perturbation Signatures 1.0 null FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.951743 AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299575 BL5906 (NFRKB) NURSA Protein Complexes 1.0 null GSE57871_5_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_5_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.992821 CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_2_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null GSE233679_12_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null Dry eye syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.44 MCF7_2-Methoxyestradiol_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136677 CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.46888 SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null r2 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42331 PFKP Pathway Commons Protein-Protein Interactions 1.0 null GSE200839,GSE233826_5_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22292 Lacrimal apparatus disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 CaSki cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.113 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.31819 GSE121866_0_v_3_six4_human RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.95739 TAGLN2 Pathway Commons Protein-Protein Interactions 1.0 null K562_Quercetin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153038 CTCF_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.96104 NUP93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85242 disheveled coat MGI Mouse Phenotype Associations 2023 1.0 null GSE215132_2_v_0_ptpn2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.886106 Nucleus of the solitary tract, commissural part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35811 primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05928 GTEX-S341-1226-SM-4AD5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.20256 SUPT16H Pathway Commons Protein-Protein Interactions 1.0 null Retrosplenial area, dorsal part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06701 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null Penis_Foreskin_Keratinocyte_Primary_Cells_skin02 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.35913 increased freezing behavior MGI Mouse Phenotype Associations 2023 1.0 null GSE193258,GSE193259_5_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Daphnetin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176062 HEP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null FE-64-KC49_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257928 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Dental papilla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.197 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null chinese GeneRIF Biological Term Annotations 1.0 null ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_NVP-BSK805 2HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131613 Amelogenesis imperfecta type 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.615 CAL120_BREAST CCLE Cell Line Proteomics 1.0 2.91174 RNF2-27304074-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null overexpression GeneRIF Biological Term Annotations 1.0 null LD-69-ZV56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.38641 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.96506 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRK2 Kinase Library Serine Threonine Kinome Atlas 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null Pallidum, caudal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00517 SNU119 CCLE Cell Line Gene CNV Profiles 1.0 3.26698 EIF3A Pathway Commons Protein-Protein Interactions 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42402 TBR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8949 A549_Resminostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151711 K2 COSMIC Cell Line Gene Mutation Profiles 1.0 null AA-68-MW92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202482 GTEX-OXRL-0626-SM-3NM9C GTEx Tissue Sample Gene Expression Profiles 1.0 1.35811 HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09804 GTEX-S7PM-0126-SM-4AD6S GTEx Tissue Sample Gene Expression Profiles 1.0 0.85988 NR2F2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Enamel organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.703 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null hsa-miR-4459 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Breast_vHMEC Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.91499 HCC1143_BREAST CCLE Cell Line Proteomics 1.0 3.54834 CDK17 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKIV2L2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_1_v_6_palm_human RummaGEO Gene Perturbation Signatures -1.0 null GSE234334,GSE234336_1_v_0_zhx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.21984 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.274 EGR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.2796 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF5A Pathway Commons Protein-Protein Interactions 1.0 null A388 DepMap CRISPR Gene Dependency 1.0 5.99673 Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amelogenesis imperfecta HPO Gene-Disease Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gingiva TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.413 8109_SLC7A6OS_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.551132 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.344 FD-62-ZB67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.675554 GSE240896,GSE240899_2_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures -1.0 null globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.71405 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YWHAG Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92183 H3K27me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SCC25 DepMap CRISPR Gene Dependency 1.0 5.08973 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96417 GSE236502_1_v_3_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null ZEB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.69043 RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HIRA Pathway Commons Protein-Protein Interactions 1.0 null GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Sec61 translocon complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.634 FAM110B Pathway Commons Protein-Protein Interactions 1.0 null GSE160083,GSE160084_1_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.71207 RPL23 Pathway Commons Protein-Protein Interactions 1.0 null GSE233679_6_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null KB-78-BE93_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.392737 CTCF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.739414 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XAJ8-0826-SM-47JY6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00277 GSE148263_6_v_0_trim3_human RummaGEO Gene Perturbation Signatures -1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VJYA-0726-SM-4KL1T GTEx Tissue Sample Gene Expression Profiles 1.0 1.70112 GSE193258,GSE193259_2_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829797 GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.985703 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.910888 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE221020,GSE221023_2_v_0_pten_mouse RummaGEO Gene Perturbation Signatures -1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null Amelogenesis imperfecta hypomaturation type 2A3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.395 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41249 Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1263 ATP8B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32327 Orbital area, ventrolateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04523 culture medium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.371619 FAM64A Pathway Commons Protein-Protein Interactions 1.0 null CAMSAP3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30834 TRIM28 Pathway Commons Protein-Protein Interactions 1.0 null upper dorsal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11909 mantle zone of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71213 RALY Pathway Commons Protein-Protein Interactions 1.0 null PMC10425715-Supplementary_material-Suppl.3-s3.docx-2-DLX3_DLX3 Rummagene Transcription Factor Associations 2026 1.0 null KRT17 Pathway Commons Protein-Protein Interactions 1.0 null A549_Ofloxacin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140457 PGK1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF Rummagene Transcription Factor Associations 2026 1.0 null abnormality of the face HPO Gene-Disease Associations 1.0 null SERBP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE111247_11_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null layer 6 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04691 MYOG_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206516,GSE206518_2_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null K562_Tazemetostat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0170762 15793299-TableC GeneSigDB Published Gene Signatures 1.0 null KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.893474 GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04157 GTEX-RU72-0726-SM-46MUW GTEx Tissue Sample Gene Expression Profiles 1.0 1.41257 GSE193993_4_v_2_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null BB-87-SF89_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36525 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19109 GSE231891_5_v_4_cdk8_human RummaGEO Gene Perturbation Signatures 1.0 null RRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10381 DB CCLE Cell Line Gene CNV Profiles -1.0 -1.62888 regulated GeneRIF Biological Term Annotations 1.0 null SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.90074 hsa-miR-661 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE218500_0_v_3_ruxolitinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.47 GSE216538_7_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_12_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null RPL5 Pathway Commons Protein-Protein Interactions 1.0 null GSE195559_6_v_1_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dental GeneRIF Biological Term Annotations 1.0 null GSE205163,GSE205164_5_v_7_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GSE200839,GSE233826_2_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null r2 part of median raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19699 CTCF ChEA Transcription Factor Targets 1.0 null STK10 Pathway Commons Protein-Protein Interactions 1.0 null doxorubicin_homo sapiens_gpl10558_gse42531 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCAPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38134 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.2604 GTEX-RVPV-0526-SM-47JYL GTEx Tissue Sample Gene Expression Profiles 1.0 1.32751 primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.836984 inner SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08123 GSE174701_4_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null CB-49-OG36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25737 Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.04882 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4039 A549_Anacardic Acid_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154424 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.562441 GTEX-QEG4-1226-SM-2S1P6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6549 Lung adenocarcinoma_LUAD_TCGA-78-7152-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RV-02A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.10756 decreased body size MGI Mouse Phenotype Associations 2023 1.0 null SYNCRIP_OE_GDS4596_85_human_SW480 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null KRT8 Pathway Commons Protein-Protein Interactions 1.0 null Columnar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.029 MYOG_myocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4697-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE216043_11_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null incisor TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.719113 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PQ-0626-SM-3NMCU GTEx Tissue Sample Gene Expression Profiles 1.0 1.40258 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05735 GSE158834_10_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null posterior tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31991 RPS27 Pathway Commons Protein-Protein Interactions 1.0 null GSE100464,GSE100465_0_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151412_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE123638,GSE123639_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.18185 PSMA7 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RNOR-0126-SM-2TF57 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848473 anterior tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4083 CTCF ENCODE Transcription Factor Targets 1.0 null BA-15-VE07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207436 RBM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59234 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CAMKK2 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997113 EZH2 ChEA Transcription Factor Targets 1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE158834_2_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Danusertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0133314 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FKBP4 Pathway Commons Protein-Protein Interactions 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null u937 HPA Cell Line Gene Expression Profiles -1.0 -0.851649 Lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.254 GTEX-T8EM-1626-SM-3DB7K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07066 calcinosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.311014 GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.00388 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WXYG-2026-SM-4E3IY GTEx Tissue Sample Gene Expression Profiles 1.0 0.965303 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39668 caki2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.623 ZNF610 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 89.8831 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, lateral agranular part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22647 GTEX-QCQG-1726-SM-3GIJ9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.824836 heart valve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.259591 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNMC-0526-SM-4DM69 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26602 Vesiculobullous skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.604 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939364 Perturb_8785_KO_HNF6_SRP217514 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.52607 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_left-x_TFEB_KO_con_VS_WT_con_DOWN_TFEB Rummagene Transcription Factor Associations 2026 1.0 null K562_SRT1720 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162122 GTEX-PSDG-0226-SM-33HC1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.899539 DSG1 Pathway Commons Protein-Protein Interactions 1.0 null high-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.59896 Amelogenesis Imperfecta DisGeNET Gene-Disease Associations 1.0 null GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null XPO1 Pathway Commons Protein-Protein Interactions 1.0 null VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.25629 Brain - Hippocampus GTEx Tissue Gene Expression Profiles 2023 1.0 2.58458 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10913870-pr3c00632_si_001.pdf-118-ZNF592_ZNF592 Rummagene Transcription Factor Associations 2026 1.0 null dry eye syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.313915 CTCF_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU8 DepMap CRISPR Gene Dependency 1.0 2.95864 HPRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01747 SNAI1_01_69 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.64534 MERO95 DepMap CRISPR Gene Dependency 1.0 3.94976 A549_BMS-754807_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0102461 GTEX-UPK5-1526-SM-4JBJA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849445 CTCF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974033 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30885 GSE227039_1_v_0_lamtor5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64446 ZC3H11A ENCODE Transcription Factor Targets 1.0 null GPRC5A Pathway Commons Protein-Protein Interactions 1.0 null EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null stomach_3b HPA Tissue Sample Gene Expression Profiles 1.0 1.71551 CSNK1A1L Pathway Commons Protein-Protein Interactions 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31784 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null SW48 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE206729_5_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null SARS-CoV MA15_Day2-PFU-10^3_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.47822 OPM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.8808 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JVE015 DepMap CRISPR Gene Dependency 1.0 2.78605 GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26014 GSE196259_2_v_3_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RWSA-0526-SM-2XCBC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99169 stomach HPA Tissue Gene Expression Profiles 1.0 0.891412 RPS14 Pathway Commons Protein-Protein Interactions 1.0 null prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null UMUC5 DepMap CRISPR Gene Dependency 1.0 5.01012 GTEX-TML8-1526-SM-4DXUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.21527 GTEX-TSE9-2826-SM-4DXTF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18402 HNRNPA3 Pathway Commons Protein-Protein Interactions 1.0 null HC-01-FD24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.46079 ameloblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.431843 GSE158834_2_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.42612 IKBKG Pathway Commons Protein-Protein Interactions 1.0 null 496100323_FWM_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0379 APOB Pathway Commons Protein-Protein Interactions 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.274591 GSE111035,GSE111040_8_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null localizes GeneRIF Biological Term Annotations 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gingival fibromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.438 CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145476_2_v_0_hopx_mouse RummaGEO Gene Perturbation Signatures -1.0 null TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.4097 ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07295 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null delayed tooth eruption MGI Mouse Phenotype Associations 2023 1.0 null GSE71529,GSE71558_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Adult Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.87436 EIF4G2 Pathway Commons Protein-Protein Interactions 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.247 GSE132948,GSE132949_2_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null DDX21 Pathway Commons Protein-Protein Interactions 1.0 null EGFR Pathway Commons Protein-Protein Interactions 1.0 null HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7765 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128844_0_v_1_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 SW1116 DepMap CRISPR Gene Dependency 1.0 7.64803 anisometropia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.04672 Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RO-01A-12R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135705_5_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064506 GSE239844_11_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08825 GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954775 irinotecan_rattus norvegicus_gpl1355_stomach_gds3466 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain oligodendroglioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.821 diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.6209 RAN Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Baricitinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161772 Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31214 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.52961 Protein of unknown function DUF1669 InterPro Predicted Protein Domain Annotations 1.0 null K562_Amisulpride_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163614 PMC6683136-41598_2019_47363_MOESM5_ESM.xlsx-GENE_SET-Negative_correlation_of_ZEB1_and_other_genes_ZEB1 Rummagene Transcription Factor Associations 2026 1.0 null PDPK1 Pathway Commons Protein-Protein Interactions 1.0 null KG1 CCLE Cell Line Gene CNV Profiles 1.0 2.02784 abnormality of the head HPO Gene-Disease Associations 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138841_0_v_1_trim6_human RummaGEO Gene Perturbation Signatures -1.0 null Invertebrate mandible TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.006 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.851712 inner SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.895686 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885978 FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.285013 NCIH1975 CCLE Cell Line Gene CNV Profiles -1.0 -1.54849 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226115,GSE226116_2_v_0_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69601 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.967555 secreted GeneRIF Biological Term Annotations 1.0 null COR-L32 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85245 SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.04824 GTEX-WFJO-2026-SM-4LVM3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.8693 EIF3F Pathway Commons Protein-Protein Interactions 1.0 null hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.833005 NCI-H1650 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.711 mantle zone of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01817 1197_CARS_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.788169 CEBPD ENCODE Transcription Factor Targets 1.0 null GSE186810,GSE186813_3_v_5_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null EWS-26573619-CHIP-SEQ-HEK293-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00159 SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MES-SA Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.70893 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63214 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IF-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG7-2326-SM-3GIKV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90755 Perturb_6729_KD_jouvence_SRP288327 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.08646 MCF7_TMP195_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138185 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE158743_1_v_2_nfkbia_human RummaGEO Gene Perturbation Signatures -1.0 null Neurosphere_Cultured_Cells_Cortex_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.830857 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07194 GSE123105,GSE124556_0_v_2_pcf11_human RummaGEO Gene Perturbation Signatures -1.0 null NC-52-AG88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.368006 RPL11 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Sirtinol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143303 FAM199X Pathway Commons Protein-Protein Interactions 1.0 null PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF Rummagene Transcription Factor Associations 2026 1.0 null SNX24 Pathway Commons Protein-Protein Interactions 1.0 null GSE225656_2_v_1_tsc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SE5C-1126-SM-4BRWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.1708 GTEX-XUJ4-2426-SM-4BOO3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.852576 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33115 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-1726-SM-4E3IF GTEx Tissue Sample Gene Expression Profiles 1.0 1.05111 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22381 PRKAB2 Pathway Commons Protein-Protein Interactions 1.0 null heart_5b HPA Tissue Sample Gene Expression Profiles -1.0 -0.90099 GSE70499_5_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null required GeneRIF Biological Term Annotations 1.0 null superficial stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42548 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Navitoclax_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142454 PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null danish GeneRIF Biological Term Annotations 1.0 null SREBF2 ChEA Transcription Factor Targets 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WI4N-1026-SM-3LK7N GTEx Tissue Sample Gene Expression Profiles 1.0 0.911513 MG63 CCLE Cell Line Gene CNV Profiles 1.0 1.66821 keratin GeneRIF Biological Term Annotations 1.0 null MAFF ENCODE Transcription Factor Targets 1.0 null MCF7_UNC0379_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180709 limited GeneRIF Biological Term Annotations 1.0 null amelogenesis GeneRIF Biological Term Annotations 1.0 null GTEX-O5YW-1826-SM-2YUN2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957643 CITED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72484 PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null contribute GeneRIF Biological Term Annotations 1.0 null GTEX-S341-0726-SM-4AD5R GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83289 CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-1026-SM-4JBHE GTEx Tissue Sample Gene Expression Profiles 1.0 1.36381 GSE233679_14_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.382388 centromedian nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0253 GTEX-X638-0326-SM-47JY1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09455 TE11 DepMap CRISPR Gene Dependency 1.0 3.54799 SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.833896 LF-94-HB11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.22295 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null RBM4 Pathway Commons Protein-Protein Interactions 1.0 null HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19161 MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DE-00-JU18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.32016 TE1 DepMap CRISPR Gene Dependency 1.0 3.09225 496100478_HIP_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03376 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00419 GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1747 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.732 GTEX-S32W-0926-SM-4AD5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.41545 EGR1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-1626-SM-3K2AY GTEx Tissue Sample Gene Expression Profiles 1.0 0.922974 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null ATF3-27146783-CHIP-SEQ-COLON-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A51X-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178532_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null CTNNB1 Pathway Commons Protein-Protein Interactions 1.0 null RADX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05934 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53423 GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MB-15-ZF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.641551 GSE158834_1_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null EPM2AIP1 Pathway Commons Protein-Protein Interactions 1.0 null HNRNPD Pathway Commons Protein-Protein Interactions 1.0 null intermediate filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.127613 ACACA Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-94-MC54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.229281 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4764_KO_DLG2_SRP315088 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.24671 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00787 NFYA ENCODE Transcription Factor Targets 1.0 null GSE129370_0_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.75389 PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA Rummagene Transcription Factor Associations 2026 1.0 null HRNR Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T5JW-1626-SM-3GADZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.06922 AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.11979 GSE57871_5_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null NUGC2 CCLE Cell Line Gene CNV Profiles -1.0 -1.41827 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USP34 Pathway Commons Protein-Protein Interactions 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05602 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE142210_9_v_10_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Cervical cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.443 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0526-SM-3P61C GTEx Tissue Sample Gene Expression Profiles 1.0 1.27309 hsa-miR-3667-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 r8 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41905 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0126-SM-2XCD5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.988635 VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01998 Bullous skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.44 primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.961415 periventricular stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39552 SCC9 CCLE Cell Line Gene Expression Profiles 1.0 1.71902 GSE57871_8_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Oral mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.186 PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_unique_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158502,GSE158506_3_v_0_fat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Dorsal peduncular area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17967 GSE193258,GSE193259_5_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.934823 Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 periventricular stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09259 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE57871_11_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null phenotypic abnormality HPO Gene-Disease Associations 1.0 null TALL-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.11909 GSE132948,GSE132949_0_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RBMX Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE248874_1_v_0_pcdh9_human RummaGEO Gene Perturbation Signatures -1.0 null SP1_02_67 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60356 GSE193258,GSE193259_5_v_14_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BANF1 Pathway Commons Protein-Protein Interactions 1.0 null GSE239844_4_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930087 RD-90-OY66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.490213 UBC Pathway Commons Protein-Protein Interactions 1.0 null PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab10_KDM5C-KD-up-DKD-rescued-Table_10_Up-regulated_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR Rummagene Transcription Factor Associations 2026 1.0 null A549_Tazemetostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156462 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4 Rummagene Transcription Factor Associations 2026 1.0 null WiDr cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.019 GSE158834_11_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null POU2F1-35413990-HUMAN-ARNEGCRPROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null MAPK8 Pathway Commons Protein-Protein Interactions 1.0 null GSE169356_2_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null LTV1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_2143_KO_ASCC3_SRP282634 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31291 RARB-24833708-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AHCYL1 Pathway Commons Protein-Protein Interactions 1.0 null cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047065 UPF1 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A614-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOMM34 Pathway Commons Protein-Protein Interactions 1.0 null FAM83G Pathway Commons Protein-Protein Interactions 1.0 null Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.327824 9592_UNC45A_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.788071 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77937 SAV1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69278 hsa-miR-642a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 periventricular stratum of r10Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12637 BL41 CCLE Cell Line Gene Expression Profiles -1.0 -1.9946 ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1526 KRT13 Pathway Commons Protein-Protein Interactions 1.0 null TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242468 Lung adenocarcinoma_LUAD_TCGA-86-8585-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE212486,GSE212488_2_v_3_gata4_mouse RummaGEO Gene Perturbation Signatures -1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32684 ENKD1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3756_KD_PPDPF_SRP317954 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE133070_2_v_4_prss1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WYJK-0126-SM-3NMAB GTEx Tissue Sample Gene Expression Profiles 1.0 1.01835 A549_Crizotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127394 FOXA1 ENCODE Transcription Factor Targets 1.0 null BD-15-VR68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287975 Renal Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE147210_3_v_4_kmt2d_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null MAPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29783 TARDBP Pathway Commons Protein-Protein Interactions 1.0 null abnormal behavior IMPC Knockout Mouse Phenotypes 1.0 null IPO7 Pathway Commons Protein-Protein Interactions 1.0 null GANAB Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975452 organelle LOCATE Predicted Protein Localization Annotations 1.0 null NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.01843 H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GNPAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04523 PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871998 primary motor cortex (area M1, area 4)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.836629 Anterior cingulate area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2351 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CF-24-KQ98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.966885 PSMA2 Pathway Commons Protein-Protein Interactions 1.0 null medial tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17 Perturb_322_KD_USP39_SRP279798 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 DDX5 Pathway Commons Protein-Protein Interactions 1.0 null VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34226 KDM1A ENCODE Transcription Factor Targets 1.0 null LU-99A COSMIC Cell Line Gene Mutation Profiles 1.0 null CDK3 Pathway Commons Protein-Protein Interactions 1.0 null PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_5096_KO_Cbx1/Cbx3/Cbx5_SRP104194 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.67784 K562_BMS-265246_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155444 Teeth hard tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.899 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46584 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.477 Lung squamous cell carcinoma_LUSC_TCGA-85-8481-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5 Rummagene Transcription Factor Associations 2026 1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17196 CCT2 Pathway Commons Protein-Protein Interactions 1.0 null VZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03856 PTBP2 Pathway Commons Protein-Protein Interactions 1.0 null FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.9155 GSE226316_3_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null submedius thalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0082 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46002 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TEAD2_TEAD2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XK95-1026-SM-4GIDV GTEx Tissue Sample Gene Expression Profiles 1.0 1.20239 GTEX-UPJH-0926-SM-4IHKA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27507 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.968384 Perturb_5279_OE_Mnx1_ERP140947 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.38815 H3K36me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-1726-SM-4DXUQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.35149 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1052 SKMM2 CCLE Cell Line Gene CNV Profiles 1.0 1.68059 etiology GeneRIF Biological Term Annotations 1.0 null epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057013 Perturb_14114_KD_ATF7IP_SRP156289 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -18.8861 KA-29-AB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.95726 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19161 GSE182179_0_v_1_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SNMC-1526-SM-2XCFN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933608 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.07221 PPIH Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2323 PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null TNK2 Pathway Commons Protein-Protein Interactions 1.0 null Ventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43537 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE138633_2_v_0_bag3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UJHI-0926-SM-4IHKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02461 HARA CCLE Cell Line Gene CNV Profiles 1.0 1.6941 abnormal heart morphology MGI Mouse Phenotype Associations 2023 1.0 null dominant GeneRIF Biological Term Annotations 1.0 null GSE236502_2_v_3_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_12533_KD_CK5_SRP342397 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 weakness MGI Mouse Phenotype Associations 2023 1.0 null Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.5415 REST ENCODE Transcription Factor Targets 1.0 null GSE120413,GSE120447_0_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99974 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.845058 Tuberomammillary nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.14879 XRN2 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_A549_hg19_10 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211128_9_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_8_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null fam83h GeneRIF Biological Term Annotations 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HLTF Pathway Commons Protein-Protein Interactions 1.0 null PMC12549544-mmc2.xlsx-AA_D7_VS_D14-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null truncating GeneRIF Biological Term Annotations 1.0 null GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46265 GSE193999,GSE194000_3_v_2_atf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE211931_2_v_3_ncoa4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33878 CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.726938 primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.866237 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.852843 GSE132948,GSE132949_0_v_1_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE174701_5_v_3_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null Amelogenesis imperfecta type 1J DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.259 cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Zfp36l2_deficiency_GDS3574_153_mouse_E14.5 fetal liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.027213 K562_TAK-901_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138535 GD-82-CS38_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.37053 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Taenia tecta, dorsal part, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24024 GSE116810_5_v_3_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null MYC_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoskeleton GeneRIF Biological Term Annotations 1.0 null calcification GeneRIF Biological Term Annotations 1.0 null GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ameloblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.047 TEAD4_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-0126-SM-4DM6O GTEx Tissue Sample Gene Expression Profiles 1.0 0.919261 mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70208 639-V COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE131649_4_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCAT-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.110428 GSE146074_10_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superficial stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48278 OVCAR-8 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30049 GET4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02903 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RPMI-8402 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-T6MO-1926-SM-32QOJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909888 G124 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.963058 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPJH-0326-SM-3GADU GTEx Tissue Sample Gene Expression Profiles 1.0 0.852564 EOMES JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9748 GSE153836_14_v_5_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Bed nuclei of the stria terminalis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01169 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051676 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Resveratrol_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0206332 PHF8 ENCODE Transcription Factor Targets 1.0 null GSE245270_1_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06415 GSE184892_0_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BACH1 Pathway Commons Protein-Protein Interactions 1.0 null PSMA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1513 mantle zone of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16648 LGALS3BP Pathway Commons Protein-Protein Interactions 1.0 null SP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.920529 reports GeneRIF Biological Term Annotations 1.0 null inner dental epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.835737 PDK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16741 septostriatal transition area (accumbens) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16036 Anterior cingulate area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01411 EZH2 ENCODE Transcription Factor Targets 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30254 Sarcoma_SARC_TCGA-DX-A8BP-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CB-32-EI69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.650414 E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP57 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0831 PCSK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66192 HARA CCLE Cell Line Gene Expression Profiles 1.0 1.88174 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null eight GeneRIF Biological Term Annotations 1.0 null K562_BMS-536924_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0221685 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.482817 GABARAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25425 Orbital area, ventrolateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06113 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gingivitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.434 AD-18-XC14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.548013 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.87086 RPS6 Pathway Commons Protein-Protein Interactions 1.0 null dental enamel hypoplasia DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null hsa-miR-423-5p MiRTarBase microRNA Targets 1.0 null NCIH1781 CCLE Cell Line Gene CNV Profiles 1.0 2.42203 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11883 MXI1 ENCODE Transcription Factor Targets 1.0 null GTEX-T5JC-1726-SM-4DM6U GTEx Tissue Sample Gene Expression Profiles 1.0 1.05715 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.03664 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null truncated GeneRIF Biological Term Annotations 1.0 null XRCC6 Pathway Commons Protein-Protein Interactions 1.0 null LRRC8D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13685 GTEX-XYKS-1726-SM-4E3IO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82428 GSE113106_2_v_1_dnm2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.9962 301_ANAPC10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.612931 IKBKE Pathway Commons Protein-Protein Interactions 1.0 null does GeneRIF Biological Term Annotations 1.0 null superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28709 lacrimal apparatus disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.285086 mRNA_KAT5_22196727 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MAF1_02_81 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59534 PSMC5 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135030_11_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.51329 SMC4-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-UJHI-0826-SM-4IHLM GTEx Tissue Sample Gene Expression Profiles 1.0 1.49466 WC-82-YS26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.401311 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUGT1 Pathway Commons Protein-Protein Interactions 1.0 null GSE255432_6_v_2_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M7-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF4-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-0726-SM-48TCS GTEx Tissue Sample Gene Expression Profiles 1.0 1.38079 GSE128240_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null AE-32-DP61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.24467 GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.2241 acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.0488 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24058 glucose metabolism disease GWASdb SNP-Disease Associations 1.0 0.286803 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20311 STX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30344 PSMA6 Pathway Commons Protein-Protein Interactions 1.0 null DE-73-JX23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.499627 Rapamycin vs Ctrl_Exp1_MEFs (Mouse) [21659605] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NY Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.34377 Buccal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.252 GTEX-WWYW-0426-SM-3NB31 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81247 GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null GTEX-T5JW-1326-SM-4DM5G GTEx Tissue Sample Gene Expression Profiles 1.0 1.33628 COPS5 Pathway Commons Protein-Protein Interactions 1.0 null KYSE-50 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-P4QT-2026-SM-3NMCJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825819 LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE237040_4_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -2.13818 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.91364 LASV_FML29_8hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.73516 GF1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SN8G-0126-SM-32PLI GTEx Tissue Sample Gene Expression Profiles 1.0 0.915509 HNF4A ChEA Transcription Factor Targets 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FADU_UPPER_AERODIGESTIVE_TRACT CCLE Cell Line Proteomics 1.0 3.09104 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_left-y_TFEB_KO_LLOMe_VS_WT_LLOMe_DOWN_TFEB Rummagene Transcription Factor Associations 2026 1.0 null CC-03-PW00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.387969 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831081 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.84131 cranium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.115381 Retrosplenial area, lateral agranular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12508 DA-85-SU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.42347 MCF 10A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null BE-04-AN21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347208 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKM Pathway Commons Protein-Protein Interactions 1.0 null H357 DepMap CRISPR Gene Dependency 1.0 4.63016 GSE111247_14_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.0216 HOXA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15999 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35207 STAT3 ChEA Transcription Factor Targets 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ae2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.93 SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.930298 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05101 KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.835982 GSE202434,GSE202438_4_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.824426 HMMR Pathway Commons Protein-Protein Interactions 1.0 null GSE229468,GSE229471_0_v_3_znf587_human RummaGEO Gene Perturbation Signatures -1.0 null ck1alpha GeneRIF Biological Term Annotations 1.0 null ATN-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Dental pulp disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.284 Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cone-rod dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.345 HCC1195 CCLE Cell Line Gene Expression Profiles 1.0 1.78877 DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.640916 MCC Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7146-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_4_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-766 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5 ENCODE Transcription Factor Targets 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MH-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.441 GSE149096_4_v_3_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DC-01A-31R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.01107 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12611713-Table2.xlsx-Sheet_1-Training_Database_AND_Validation_Database_NOT_Diabetes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null ZNF592 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08725 GTEX-R55C-0826-SM-48FCL GTEx Tissue Sample Gene Expression Profiles 1.0 1.28237 GTEX-TMMY-1126-SM-4DXSX GTEx Tissue Sample Gene Expression Profiles 1.0 1.33198 MARK3 Pathway Commons Protein-Protein Interactions 1.0 null CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.795048 SK-MES-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.547 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.906457 TCF7-22412390-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CHK1_KD_GSE54267_671_human_U2OS GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null colonrectum_f HPA Tissue Sample Gene Expression Profiles 1.0 0.826019 AA-99-HO76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.938348 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null KRT6A Pathway Commons Protein-Protein Interactions 1.0 null GSE70499_3_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null D-566MG COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.3201 nuclear GeneRIF Biological Term Annotations 1.0 null CTCF_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoproteome_AKT2_KD_vs_SCR-Unnamed_3_AR Rummagene Transcription Factor Associations 2026 1.0 null CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39037 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null esophagus HPA Tissue Gene Expression Profiles 1.0 1.02164 rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.314941 GTEX-WY7C-2826-SM-3NB3Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827687 PERK Kinase Library Serine Threonine Kinome Atlas 1.0 null PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_39_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33756 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA41-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSK3A Pathway Commons Protein-Protein Interactions 1.0 null K562_Rigosertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154778 GSE169205_0_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Periodontal ligament cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.755 GSE210885_2_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.893537 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tooth germ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.624 GSE201042_2_v_4_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.1823 MCF7_G007-LK_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139484 HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11771 GSE158834_10_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-REY6-1326-SM-48FDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.36596 floret TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.098334 GSE135030_3_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858318 ZDHHC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1651 tooth disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fetus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-WZTO-0126-SM-3NM95 GTEx Tissue Sample Gene Expression Profiles 1.0 0.834007 GSE118939_1_v_0_nras_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null prostate gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.889433 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060108 PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null GSE239844_6_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.928267 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPR Pathway Commons Protein-Protein Interactions 1.0 null MAGOH Pathway Commons Protein-Protein Interactions 1.0 null Amelogenesis imperfecta, hypocalcification type ClinVar Gene-Phenotype Associations 1.0 null NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902542 plant bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.730208 RPS6KA1 Pathway Commons Protein-Protein Interactions 1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.403549 TEAD4 ENCODE Transcription Factor Targets 1.0 null SARS-CoV MA15_Day2_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.10291 GTEX-S4Q7-0626-SM-4AD5M GTEx Tissue Sample Gene Expression Profiles 1.0 1.37968 SYK Pathway Commons Protein-Protein Interactions 1.0 null GSE201309_1_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Cimetidine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154671 GSE223287,GSE223290_2_v_4_braf_mouse RummaGEO Gene Perturbation Signatures 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Clear cell renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.232 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null GSE227698_5_v_3_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE96649_1_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Divalproex Sodium_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0215718 No annotation - 1 CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H11A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135514_2_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.292 GSE132948,GSE132949_0_v_5_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CB-44-RT90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.343067 ALYREF Pathway Commons Protein-Protein Interactions 1.0 null KNS42 CCLE Cell Line Gene CNV Profiles -1.0 -1.75587 IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.853501 SNU-182 COSMIC Cell Line Gene Mutation Profiles 1.0 null septopallidal core nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.662 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null CSE1L Pathway Commons Protein-Protein Interactions 1.0 null BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.10333 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null 2130_DDX54_P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.589671 GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89424 amelogenesis imperfecta, type iii OMIM Gene-Disease Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-EP-A3JL-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ME-62-IQ37_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207329 H3K27me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-85-LB25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.603977 SLC35B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19823 HCC1395 CCLE Cell Line Gene CNV Profiles 1.0 1.38858 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL24 Pathway Commons Protein-Protein Interactions 1.0 null AB-18-YN11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377322 PIM1 Pathway Commons Protein-Protein Interactions 1.0 null RBMS1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab6_KDM5C-KD-up_genes-Table_6_Up_regulated_genes_in_KDM5C-KD_KDM5C-KD1_Control_overlap_KDM5C-KD2_Control_AR Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901409 epidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 NR2C2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE232786_1_v_0_otud1_human RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03739 CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38579 K562_Meprednisone_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152446 H3K36me3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.324709 VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52191 GSE138019_3_v_2_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 114.305 GTEX-SIU8-0126-SM-2XCDT GTEx Tissue Sample Gene Expression Profiles 1.0 0.904814 KRT6B Pathway Commons Protein-Protein Interactions 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_6_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null AAK1 Pathway Commons Protein-Protein Interactions 1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878892 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4781-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.572 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45706 GSE211128_3_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SERPINB12 Pathway Commons Protein-Protein Interactions 1.0 null GSE103068_5_v_3_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.419 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.991701 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.34478 PDCD7 Pathway Commons Protein-Protein Interactions 1.0 null GSE99187_1_v_0_gemcitabine_mouse RummaGEO Drug Perturbation Signatures -1.0 null RPS5 Pathway Commons Protein-Protein Interactions 1.0 null GA-28-SS67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282703 KLF13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.1247 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.867806 intermediate filament GO Cellular Component Annotations 2023 1.0 null GSE125862_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Amelogenesis imperfecta ClinVar Gene-Phenotype Associations 2025 1.0 null T cell and NK cell immunodeficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.454 GTEX-WL46-0526-SM-3LK7W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910589 HS695T_SKIN CCLE Cell Line Proteomics 1.0 2.05148 GSE182921_0_v_1_slit2_human RummaGEO Gene Perturbation Signatures -1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.736 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.66771 PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153836_11_v_2_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.345 HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.574472 NRK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.667 PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B Rummagene Transcription Factor Associations 2026 1.0 null PRKAB1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.77482 GTEX-RU1J-1926-SM-2TF6S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41037 K562_CUDC-101_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177105 esophagus_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.10779 NOP2 Pathway Commons Protein-Protein Interactions 1.0 null portion GeneRIF Biological Term Annotations 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03501 HNRNPM Pathway Commons Protein-Protein Interactions 1.0 null SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21145 GTEX-SNOS-0626-SM-4DM5F GTEx Tissue Sample Gene Expression Profiles 1.0 1.14367 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Breast Cancer_Mammary gland_GSE2528 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.08638 QB-42-MC63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.422622 TBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9199 periventricular stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83635 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07538 NC-27-AD53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.335012 periventricular stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97939 SNU1041 CCLE Cell Line Gene Expression Profiles 1.0 1.78 ELF5 ChEA Transcription Factor Targets 1.0 null keratin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.502693 SPSB1 Hub Proteins Protein-Protein Interactions 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05176 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.83901 HAL-01 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.61487 NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.782784 r9 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68923 r2 part of prepontine raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72115 PMC10205041-Table1.doc-0-ADNP_ADNP Rummagene Transcription Factor Associations 2026 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09445 GTEX-OIZG-1026-SM-3LK5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.66704 GSE240027,GSE240030_1_v_2_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer SZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.844946 biofilm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.965063 PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20135 superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26066 RANBP2 Pathway Commons Protein-Protein Interactions 1.0 null GSE133087_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.931349 SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 other source TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.284253 GTEX-XV7Q-1226-SM-4BRVT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858827 Apical bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.793 sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.15433 DC-51-WE27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.348192 Nr1h3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.4254 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KRT5 Pathway Commons Protein-Protein Interactions 1.0 null STAT3-18555785-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902542 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Zfx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 46.5752 GSE180185_7_v_1_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5024-01A-21R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FU-OV-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.62973 Alveolar bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.47 Perturb_3251_KD_RBM38_SRP091017 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.29529 GSE208254_3_v_2_irf8_mouse RummaGEO Gene Perturbation Signatures 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.867906 GTEX-T6MO-0626-SM-4DM6P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867132 blood vessel GTEx Tissue Gene Expression Profiles -1.0 -1.01156 decreased exploration in new environment MGI Mouse Phenotype Associations 2023 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.481 r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47077 S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.855844 UM-UC-14 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.91 ZNF148 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 128.179 MAP3K7_knockdown_37_GDS5023 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.25387 teeth hard tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.94172 RRP36 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.096034 ventral tuberomammillary nucleus, superficial part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48197 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.70616 GTEX-S3XE-1826-SM-3K2B4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8339 r6 part of ventral gigangocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71213 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937293 GSE142210_4_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.29541 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU308 DepMap CRISPR Gene Dependency 1.0 3.372 EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.307783 M059J Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.942295 CHAGOK1 CCLE Cell Line Gene Expression Profiles 1.0 1.54383 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.830503 VRK1_knockout_64_GSE19329 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.631152 RPN1 Pathway Commons Protein-Protein Interactions 1.0 null GSE148200_3_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SN8G-0526-SM-32PLE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70272 vitamin c_homo sapiens_gpl6884_gse16590 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BA-10-WH12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261851 PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GSE158197_0_v_4_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE188382_4_v_0_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.913383 SU-DHL-8 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.64253 Amelogenesis imperfecta type 3A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.571 GSE195503_1_v_0_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null SARS-CoV MA15_Day4-C57BL-6_None_GSE40824 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.58095 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 hsa-miR-4723-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 496100518_HIP_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.59268 r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20854 esophagus HPA Tissue Protein Expression Profiles 1.0 1.62621 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.093 FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.574 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null khos/np TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.866 MCF7_Crizotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0221649 GTEX-POMQ-2126-SM-2S1OJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67654 GSE201309_5_v_7_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null LS513 CCLE Cell Line Gene Expression Profiles 1.0 1.73065 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.8612 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172016_2_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH510 CCLE Cell Line Gene CNV Profiles -1.0 -1.33528 mRNA_KLF5_20875108 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.940026 lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.336446 CDC5L Pathway Commons Protein-Protein Interactions 1.0 null CCDC78 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27091 Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWS6-0826-SM-47JXF GTEx Tissue Sample Gene Expression Profiles 1.0 1.38436 increased freezing behavior IMPC Knockout Mouse Phenotypes 1.0 null CAMA1 DepMap CRISPR Gene Dependency 1.0 2.68998 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4UY-0426-SM-3K2AF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93361 YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.699878 A549_FLLL32_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189433 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04701 terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06196 Olfactory organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.681 A673 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YV-1026-SM-3LK72 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36895 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.35172 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.704 MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1667 Cauline leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.571 OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924712 NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37299 LIM1215 COSMIC Cell Line Gene Mutation Profiles 1.0 null ND-15-RC31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.688413 EXOSC10 Pathway Commons Protein-Protein Interactions 1.0 null GSE147893,GSE147897_2_v_1_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902542 GSE158834_12_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257635 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Perturb_11594_OE_MYOD1_SRP106379 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.266 Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null Perturb_12711_KD_KMT2D_SRP062172 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.40729 GSE157555,GSE157556_0_v_6_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.853335 GSE158197_2_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QV44-1926-SM-2S1RF GTEx Tissue Sample Gene Expression Profiles 1.0 0.893575 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UH-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.078915 Epidermolysis bullosa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.606 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.76731 SMC3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8MGBA CCLE Cell Line Gene Expression Profiles -1.0 -1.77299 GSE233679_14_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null EB-67-WB79_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247735 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6998-01A-23R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE150669_0_v_1_roxadustat_mouse RummaGEO Drug Perturbation Signatures 1.0 null AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.530047 r2 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42763 GTEx Lung 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -6.06441 RUVBL2 Pathway Commons Protein-Protein Interactions 1.0 null dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.875656 PMC12047497-mmc5.xlsx-Sheet1-GSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_UP_HNF1A Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216043_11_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE184892_6_v_3_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null GSE157555,GSE157556_5_v_6_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H2110 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 EGR1 ChEA Transcription Factor Targets 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.30633 SW837_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 2.17447 ChIP_CTCF_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29273 CE-96-GH46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.467355 BA-46-YF32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222676 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831081 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0626-SM-3NM9X GTEx Tissue Sample Gene Expression Profiles 1.0 0.954727 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPA2 Pathway Commons Protein-Protein Interactions 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null Renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCT7 Pathway Commons Protein-Protein Interactions 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.372 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.60825 TMEM14C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15095 Lateral septal nucleus, caudal (caudodorsal) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07623 RPL12 Pathway Commons Protein-Protein Interactions 1.0 null organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC11385326-joces-137-261952-TableS5.xlsx-AP4_possible_interactors-Gene_names_AP4_REPIN1 Rummagene Transcription Factor Associations 2026 1.0 null SNRPD3 Pathway Commons Protein-Protein Interactions 1.0 null NZOV9 DepMap CRISPR Gene Dependency 1.0 2.46944 YAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.3758 RIPK2 Kinase Library Serine Threonine Kinome Atlas 1.0 null CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE158834_7_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE122215,GSE122217_0_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QLQ7-0926-SM-447BC GTEx Tissue Sample Gene Expression Profiles 1.0 1.28016 GSE144838_4_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null CAMA1 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.925346 CF-24-KQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.12079 AHNAK Pathway Commons Protein-Protein Interactions 1.0 null ELK4-26923725-CHIP-SEQ-MESODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.941266 RAMOS-2G6-4C10 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOL8 Pathway Commons Protein-Protein Interactions 1.0 null MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33831 SPTAN1 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Tazemetostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016381 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRKAG2 Pathway Commons Protein-Protein Interactions 1.0 null CSNK2A1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WRHK-1426-SM-3MJF9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.834673 VIPAS39 Pathway Commons Protein-Protein Interactions 1.0 null EMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01598 ACOT8 Pathway Commons Protein-Protein Interactions 1.0 null HC-01-FD24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.536097 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.21229 tooth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.47682 Skin Cutaneous Melanoma_SKCM_TCGA-RP-A6K9-06A-41R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198794_2_v_1_usp18_human RummaGEO Gene Perturbation Signatures 1.0 null ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.358233 MCF7_BMS-911543_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0197907 Lung squamous cell carcinoma_LUSC_TCGA-52-7811-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE138019_4_v_5_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE186620_0_v_1_ascl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X8HC-2726-SM-46MUA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873242 ALDH3A2 Pathway Commons Protein-Protein Interactions 1.0 null SYNCRIP Pathway Commons Protein-Protein Interactions 1.0 null ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9088 Nance-Horan syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 GSE146074_9_v_11_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.568 E2F6 ENCODE Transcription Factor Targets 1.0 null midbrain reticular formation, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50163 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AB-97-BI36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.79842 individuals GeneRIF Biological Term Annotations 1.0 null plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063469 GSE128333_2_v_0_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.934128 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17563 U-266 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.72892 membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048474 abnormality of the mouth HPO Gene-Disease Associations 1.0 null MCF7_MLN8054_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172357 A549_Alisertib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0121502 CAL27_UPPER_AERODIGESTIVE_TRACT CCLE Cell Line Proteomics 1.0 3.31213 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 RUNX2 ChEA Transcription Factor Targets 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.089 ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3704 EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DC-84-GJ21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.459855 superficial stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71019 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null BMP2K Pathway Commons Protein-Protein Interactions 1.0 null ICC2 DepMap CRISPR Gene Dependency 1.0 3.26756 MSTO-211H COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE119978,GSE180930_6_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE131649_2_v_11_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null KRT19 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09259 GSE148657_3_v_0_cd44_human RummaGEO Gene Perturbation Signatures -1.0 null BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.73722 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PANC0813 DepMap CRISPR Gene Dependency 1.0 3.14125 Bladder disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 laminin-5 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.241 A549_Motesanib Diphosphate_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0104083 VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.896366 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Danusertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0123335 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.12822 GSE135352_6_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18747 NU-DUL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null a-REST (TW) (REST) NURSA Protein Complexes 1.0 null p1B part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01974 Amelogenesis imperfecta type 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.96 prostate adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.418394 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.333763 GSE146074_6_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null amelogenesis imperfecta DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GSE149359_2_v_1_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.405108 ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09259 SMARCA4 ChEA Transcription Factor Targets 1.0 null GSE57871_11_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tfcp2l1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 60.6342 BT-474 COSMIC Cell Line Gene Mutation Profiles 1.0 null rhombomere 10 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24588 CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Keratoconjunctivitis sicca DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.735 SBC-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null MYD88_Deficiency_GDS2650_652_mouse_LUNG GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null DLD-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5524 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE149035_1_v_0_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.26438 SNCA_KO_GDS4153_528_mouse_cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles 1.0 1.27942 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Valproic acid sodium salt_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147652 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gall bladder cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.763 immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047674 GSE118077_1_v_2_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Maraviroc_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0141647 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null LU99 CCLE Cell Line Gene CNV Profiles 1.0 1.70617 amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.954231 GTEX-WHPG-2626-SM-3NMBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.16765 esophagus_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.09892 CA-73-BW50_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212261 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3393 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-125a-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.039622 AE-14-NN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.578209 ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.11922 GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Pancreatic adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 hsa-miR-4645-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4XY-0526-SM-46MW1 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.01636 GSE148263_6_v_9_trim3_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_11593_OE_MYOD1_SRP105281 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.7881 GSE174701_4_v_0_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null 19605494-TableS1 GeneSigDB Published Gene Signatures 1.0 null Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.296 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37564 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839738 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_420_KD_FOXM1_SRP239534 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.38537 GSE214931_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.539171 GTEX-UPK5-1226-SM-4IHL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28969 ZNF618 Pathway Commons Protein-Protein Interactions 1.0 null NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-1626-SM-3NB23 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04849 GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null RCC-AB COSMIC Cell Line Gene Mutation Profiles 1.0 null MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ3S-1526-SM-4BOOC GTEx Tissue Sample Gene Expression Profiles 1.0 0.999476 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCFL ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11720_KD_Plodip2_SRP303067 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.59839 mode of inheritance HPO Gene-Disease Associations 1.0 null GSE184892_6_v_5_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.207681 H3K36me3_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841846 hsa-miR-4319 TargetScan Predicted Conserved microRNA Targets 1.0 0.03694 GSE89018_11_v_14_cry2_mouse RummaGEO Gene Perturbation Signatures -1.0 null intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.650154 affected GeneRIF Biological Term Annotations 1.0 null no spontaneous movement IMPC Knockout Mouse Phenotypes 1.0 null GSE70935_3_v_5_cyfip1_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52093 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC1 Pathway Commons Protein-Protein Interactions 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-1826-SM-2TF5B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05763 PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_downregulated_RRHO_list-RRHO_concordant_degree_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49519 heart muscle HPA Tissue Protein Expression Profiles -1.0 -1.00299 PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null FKBP5 Pathway Commons Protein-Protein Interactions 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN Rummagene Transcription Factor Associations 2026 1.0 null Perturb_3525_KD_NDP52_SRP345438 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 intermediate stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15963 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1500 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.922634 normocytic anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.349717 GSE86507,GSE86509_3_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0783 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14322 GTEX-RNOR-1226-SM-48FDQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.22265 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.76229 BB-87-SF89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.451775 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13783 SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.94432 GSE173232_1_v_0_sf3b1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5051-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SUGP2 Pathway Commons Protein-Protein Interactions 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.83882 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99399 primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.865478 FLOT1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H650 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null KAT2B ENCODE Transcription Factor Targets 1.0 null NB(TU)1-10 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.73627 PMC12701967-ijmsv23p0161s1.pdf-11-ETS1_ETS1 Rummagene Transcription Factor Associations 2026 1.0 null PRKCD Pathway Commons Protein-Protein Interactions 1.0 null H3K36me3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Agranular insular area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1477 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898478 Stomach carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null acids GeneRIF Biological Term Annotations 1.0 null HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.084566 MYLK2 Pathway Commons Protein-Protein Interactions 1.0 null AE-56-SL06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303519 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null AA-56-JY17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.278939 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -2.07549 FOXA2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAMA-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8010-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.47908 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-2826-SM-3P617 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842658 embryonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064061 GSE165548_2_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SUCS-0726-SM-4DM7J GTEx Tissue Sample Gene Expression Profiles 1.0 1.46091 BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.50849 PKN2 Pathway Commons Protein-Protein Interactions 1.0 null GSE164463_4_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE57871_8_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Ovarian cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.377 KRT9 Pathway Commons Protein-Protein Interactions 1.0 null GSE121824,GSE121826_0_v_2_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_14363_KD_SORBS2_SRP112755 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 A549_WP1066_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01182 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7090-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 143B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26591 soft GeneRIF Biological Term Annotations 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 ALPP Pathway Commons Protein-Protein Interactions 1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null AGRN Pathway Commons Protein-Protein Interactions 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20107 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypercementosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.946 MARK1 Pathway Commons Protein-Protein Interactions 1.0 null CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.419122 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21466 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-1826-SM-32PK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00217 VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23086 GSE171837_0_v_3_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null MCF7_CEP-33779_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0115669 Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.14233 Perturb_10353_KO_Hbb_SRP333852 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.2176 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.53388 HES1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8426 III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.859463 SNCA_KO_GDS4153_442_mouse_Cerebellum - 6 month GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE199092_3_v_0_ddx5_human RummaGEO Gene Perturbation Signatures 1.0 null Immunodeficiency 10 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.484 GSE157555,GSE157556_4_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GNB2L1 Pathway Commons Protein-Protein Interactions 1.0 null DYRK4 Kinase Library Serine Threonine Kinome Atlas 1.0 null DYNLL2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XUZC-2026-SM-4BRW9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98559 Lung adenocarcinoma_LUAD_TCGA-99-8033-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC827 DepMap CRISPR Gene Dependency 1.0 7.31939 TEX15 Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7822-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal gallbladder morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18935 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.624 posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27473 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-1126-SM-3NM93 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17793 TUBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41797 TANK Pathway Commons Protein-Protein Interactions 1.0 null KCL-22 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.83201 dental papilla TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.757845 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPUL2 Pathway Commons Protein-Protein Interactions 1.0 null GSE242083,GSE242098_3_v_1_med1_human RummaGEO Gene Perturbation Signatures -1.0 null KRT1 Pathway Commons Protein-Protein Interactions 1.0 null SUB1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20X-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29471 PPP6R3 Pathway Commons Protein-Protein Interactions 1.0 null CFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56772 amino GeneRIF Biological Term Annotations 1.0 null LA-42-ER00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.1695 CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.335409 CKAP4 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-4467 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00198 GSE148262,GSE150691_1_v_2_hdlbp_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158182_5_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null Linear skin defects with multiple congenital anomalies 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.143 PUF60 Pathway Commons Protein-Protein Interactions 1.0 null PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135352_0_v_1_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null Internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Dental enamel hypoplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.977 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12423 KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null periventricular stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14397 URI1 Pathway Commons Protein-Protein Interactions 1.0 null GSE88819_5_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.86011 PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles 1.0 1.18542 GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.936622 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14972_KO_Max_SRP225905 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.6642 Outer dental epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.518 microspore TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.192076 GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.552521 Inflammation CTD Gene-Disease Associations 1.0 1.01324 PMC11639743-mmc2.xlsx-LIN28B-gene_name_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U3ZN-0926-SM-4DXTU GTEx Tissue Sample Gene Expression Profiles 1.0 1.00119 GSE145323,GSE145324_3_v_2_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.989733 posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.7793 GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45249 HSD17B12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35277 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DYNLL1 Pathway Commons Protein-Protein Interactions 1.0 null Ameloblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.837 ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QV44-1026-SM-447CG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832688 GSE226355,GSE226357_1_v_0_ybx1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SE5C-1226-SM-4BRWV GTEx Tissue Sample Gene Expression Profiles 1.0 1.24235 primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.955938 GSE166315_1_v_0_docetaxel_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE233679_14_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8283158-mmc2.xlsx-TCF4_NPC-Gene_TCF4 Rummagene Transcription Factor Associations 2026 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9585487-NIHMS1838959-supplement-4.xlsx-Upregulated-Table_S3_FOXC1_regulated_genes_FOXC1 Rummagene Transcription Factor Associations 2026 1.0 null GSE238018_1_v_0_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null JA-79-II25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341556 GTEX-WYJK-0526-SM-3NM8Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.923505 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-1626-SM-4IHKT GTEx Tissue Sample Gene Expression Profiles 1.0 0.838659 all GWASdb SNP-Phenotype Associations 1.0 0.032743 AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19011 GTEX-O5YT-0126-SM-48TBW GTEx Tissue Sample Gene Expression Profiles 1.0 0.924223 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8935 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.424 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BF-10-IO69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.413341 KLF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.2827 PMC12515692-MOL2-19-2882-s005.xlsx-Proteome_AKT1_AKT2_KD_vs_SCR-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null EIF3E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92923 PSMC3 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4IQ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1917 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07504 small heart IMPC Knockout Mouse Phenotypes 1.0 null Liver And Intrahepatic Biliary Tract Carcinoma DisGeNET Gene-Disease Associations 1.0 null unique GeneRIF Biological Term Annotations 1.0 null GSE188458_2_v_1_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null FLI1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null t61-colon_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.57849 ARG1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-3689a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE158632_3_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VZ-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207135_1_v_0_sod2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE240109_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null supramarginal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.846598 SAP30 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE122101,GSE122103_0_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.85547 GSE122067_3_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null M059K CCLE Cell Line Gene CNV Profiles -1.0 -1.45663 KRT16 Pathway Commons Protein-Protein Interactions 1.0 null GSE182179_2_v_1_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null RRBP1 Pathway Commons Protein-Protein Interactions 1.0 null Patent Ductus Arteriosus DisGeNET Gene-Disease Associations 1.0 null PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.412391 GTEX-XUW1-1526-SM-4BOOY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23261 proper GeneRIF Biological Term Annotations 1.0 null MCF7_Tanespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173435 CTCF_GM12867_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE134375_4_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874334 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE116354,GSE117379_2_v_4_cox2_mouse RummaGEO Gene Perturbation Signatures 1.0 null nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.839069 AC-43-ZC52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.551877 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE119978,GSE180930_3_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_2_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TF-77-DW08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.641734 no spontaneous movement MGI Mouse Phenotype Associations 2023 1.0 null K562_MK-5108_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199173 superficial dorsofrontal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.61613 GTEX-R3RS-1326-SM-48FE7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.61017 CTBP2-25329375-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1455 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.12216 GTEX-S3XE-0926-SM-4AD4S GTEx Tissue Sample Gene Expression Profiles 1.0 1.22935 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20432 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.4655 HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 single GeneRIF Biological Term Annotations 1.0 null CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.87968 caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.978881 TBX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6077 HSPA5 Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE95685_4_v_5_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.9654 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DLAT Pathway Commons Protein-Protein Interactions 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-0926-SM-4AD4M GTEx Tissue Sample Gene Expression Profiles 1.0 1.30932 Brain Lower Grade Glioma_LGG_TCGA-S9-A7QW-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.852112 Amelogenesis Imperfecta, Type III CTD Gene-Disease Associations 1.0 2.88009 CHP-126 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.29743 dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.26647 Perturb_2779_OE_ACF7_SRP109301 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.73354 GSE206516,GSE206518_0_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF485 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14552 IPO13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41605 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE130437_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.937044 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.63521 RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215325 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.952605 HIPK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null CTCF_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174701_5_v_8_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17324 ZBTB7A ENCODE Transcription Factor Targets 1.0 null USP9Y Pathway Commons Protein-Protein Interactions 1.0 null ZSWIM8 Pathway Commons Protein-Protein Interactions 1.0 null LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.917129 HNRNPU Pathway Commons Protein-Protein Interactions 1.0 null Dental Fluorosis, Acquired DisGeNET Gene-Disease Associations 1.0 null TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal coat/ hair morphology IMPC Knockout Mouse Phenotypes 1.0 null AE-19-BK71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.32245 NCIH2110 CCLE Cell Line Gene Expression Profiles 1.0 2.96944 PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3 Rummagene Transcription Factor Associations 2026 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.00133 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE181003_1_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null uterine cervix TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZNF487 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1678 GTEX-OHPN-2726-SM-2I5H4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995616 abnormality of body weight GWASdb SNP-Phenotype Associations 1.0 0.33571 KRT15 Pathway Commons Protein-Protein Interactions 1.0 null STOM Pathway Commons Protein-Protein Interactions 1.0 null ALDH18A1 Pathway Commons Protein-Protein Interactions 1.0 null MLMA Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.71229 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ncih1650 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.723 GSE216043_11_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE103068_0_v_3_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null CALCOCO2 Pathway Commons Protein-Protein Interactions 1.0 null GSE193993_5_v_6_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91174 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3066 outer SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.82886 GSE199092_1_v_0_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE248858_5_v_2_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null AA-22-UI44_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307083 GTEX-QDT8-1026-SM-43V6X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24189 environment GeneRIF Biological Term Annotations 1.0 null SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157555,GSE157556_4_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RHOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12302 hemolytic-uremic syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.624927 GTEX-X88G-0126-SM-47JZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1027 skin_5e HPA Tissue Sample Gene Expression Profiles 1.0 1.21106 PAPD7 Pathway Commons Protein-Protein Interactions 1.0 null EPAS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5125 DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210102 Stratified epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.834 mineral metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.087416 ERI2 Pathway Commons Protein-Protein Interactions 1.0 null RASAL2 Pathway Commons Protein-Protein Interactions 1.0 null peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.78652 chr8_143740421_C_T_b38 GTEx eQTL 2025 1.0 1.29056 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null NRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68111 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45502 PMC5472759-ncomms15770-s2.xlsx-KIRC_mean_chr8_GISTIC_CN_by_gen-Supplementary_Data_1_TCGA_KIRC_mean_CN_near_MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Aurora A Inhibitor I_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145449 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.21212 Stoma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.874 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE215132_2_v_3_ptpn2_mouse RummaGEO Gene Perturbation Signatures -1.0 null EEF1D Pathway Commons Protein-Protein Interactions 1.0 null GF1B-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 10min_PPase_inhibitors vs ctrl_Hepa1-6 (Mouse) [18846507] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs 1.0 null CREB1 ChEA Transcription Factor Targets 1.0 null FOXA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hematopoietic stem cell_Bone marrow_Mouse CellMarker Gene-Cell Type Associations 1.0 null BCL6-25482012-CML-JURL-MK1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190384,GSE190386_6_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8346-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Junctional epidermolysis bullosa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.732 GSE248045,GSE248046_6_v_5_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EN COSMIC Cell Line Gene Mutation Profiles 1.0 null Childhood Osteosarcoma DisGeNET Gene-Disease Associations 1.0 null PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE139455_7_v_3_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Malignant exocrine pancreas neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.3786 GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures -1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233993 HN COSMIC Cell Line Gene Mutation Profiles 1.0 null HEBP1 Pathway Commons Protein-Protein Interactions 1.0 null DYNC1LI2 Pathway Commons Protein-Protein Interactions 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04116 GSE160083,GSE160084_2_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.859065 QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.677894 all GeneRIF Biological Term Annotations 1.0 null LC-12-VN85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.60083 HNRNPA1 Pathway Commons Protein-Protein Interactions 1.0 null extracellular region part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048484 GSE201309_1_v_0_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154678 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24738 HNRNPAB Pathway Commons Protein-Protein Interactions 1.0 null Primary enamel knot TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.808 DG-75 COSMIC Cell Line Gene Mutation Profiles 1.0 null DNAJC10 Pathway Commons Protein-Protein Interactions 1.0 null Gingival overgrowth DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.488 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null K562_Valproic acid sodium salt_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0192711 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09445 GSE144346_0_v_1_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null HINFP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44602 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48695 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.996186 dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1214 Dorsal motor nucleus of the vagus nerve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45527 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNAI1_OE_GDS4596_344_human_SW480 - Colorectal cancer cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CSNK1E Pathway Commons Protein-Protein Interactions 1.0 null GSE164463_2_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE227891_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_Clevudine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164378 LOUCY CCLE Cell Line Gene Expression Profiles -1.0 -1.82392 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65394 phenotypic GeneRIF Biological Term Annotations 1.0 null GTEX-X5EB-1926-SM-4E3IW GTEx Tissue Sample Gene Expression Profiles 1.0 0.948509 KDM4A ENCODE Transcription Factor Targets 1.0 null positive regulation of cell migration GO Biological Process Annotations 2023 1.0 null ALB Pathway Commons Protein-Protein Interactions 1.0 null Dermatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 mitochondrial membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.129795 GSE210101,GSE210114_0_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GSE111061_1_v_0_tofacitinib_human RummaGEO Drug Perturbation Signatures -1.0 null HCC95 CCLE Cell Line Gene Expression Profiles 1.0 1.59977 male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.068669 GTEX-S4UY-1226-SM-4AD51 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920045 GSE103068_0_v_1_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.955011 cochlear nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.882792 UBA52 Pathway Commons Protein-Protein Interactions 1.0 null inner SZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1429 STK24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01366 TOLEDO CCLE Cell Line Gene Expression Profiles -1.0 -1.62933 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.601 Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.290307 enamel organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.688 nucleus of the stria terminalis, medial division, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2817 intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.4419 GTEX-U3ZM-0526-SM-4DXTB GTEx Tissue Sample Gene Expression Profiles 1.0 1.41042 ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.421903 FLG2 Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38504 DE-58-OW37_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.254807 mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.951973 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.882394 A549_Raltitrexed_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00927146 EGR1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TF-29-QU48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232401 FB-98-HM88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.437539 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64385 CTCF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Enamel epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.985 AB-12-IS33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278395 RPL26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31932 cdx2_20696899_caco2_lof_human_gpl570_gse22572 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.69086 GTEX-WFON-1926-SM-3LK7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.12356 NPM1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41984 nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051902 Immunodeficiency 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.868 PAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3196 GSE158834_7_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Flp-In-T-REx cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.704 HMEpC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.965 NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PSMD3 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-2681 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 LRF MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE180200,GSE180201_5_v_6_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPL7 Pathway Commons Protein-Protein Interactions 1.0 null GSE119978,GSE180930_0_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-1426-SM-4IHLQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.15511 targeting GeneRIF Biological Term Annotations 1.0 null GSE200839,GSE233826_3_v_0_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.996 GSE239844_4_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE97278,GSE97280_2_v_1_nsd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.873115 GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 0.866619 Perturb_12502_KD_SRGAP1_SRP389741 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 12.3025 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DSG2 Pathway Commons Protein-Protein Interactions 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-8163-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null JM1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.15829 Urease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.599 mantle zone of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16036 Ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.139 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.32305 MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15276 carbohydrate metabolism disease GWASdb SNP-Disease Associations 1.0 0.286803 premature death MGI Mouse Phenotype Associations 2023 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCWH syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GNG12 Pathway Commons Protein-Protein Interactions 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.634 PC-62-AQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.264187 organelle outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.161693 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21145 hypocalcified GeneRIF Biological Term Annotations 1.0 null plasma lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.116297 GTEX-P78B-1026-SM-3NMC4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19361 GSE158834_12_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null MAFK_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOT4-0426-SM-4B66T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62474 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOSL2 ENCODE Transcription Factor Targets 1.0 null Molaris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.235 CAT Pathway Commons Protein-Protein Interactions 1.0 null craniofacial region TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.105567 Osteosarcoma DisGeNET Gene-Disease Associations 1.0 null PD-70-VS77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.615167 A549_Fluorouracil_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0116253 Ameloblastic layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.61 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.43376 GSE213228_4_v_0_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.770691 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09061 Liver hepatocellular carcinoma_LIHC_TCGA-O8-A75V-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.710561 Perturb_6797_KD_BRD4_SRP063978 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-PW2O-1926-SM-2S1OB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07312 intermediate part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71338 BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261794 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923962 GSE97278,GSE97280_2_v_3_nsd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null r7 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10355 Perturb_9834_KO_miR31_SRP354225 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 HCT 116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE171572_5_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null ZBTB11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4438 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4881-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null keratoconjunctivitis sicca DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.393001 RPS10 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11045 layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.5307 GSE92364_0_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures 1.0 null primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.58077 Lung adenocarcinoma_LUAD_TCGA-55-8505-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5493_NCBP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.507345 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05035 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.40345 SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPUL1 Pathway Commons Protein-Protein Interactions 1.0 null central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE230744,GSE237803_5_v_3_hira_human RummaGEO Gene Perturbation Signatures 1.0 null enam GeneRIF Biological Term Annotations 1.0 null SOX4_01_260 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.73451 TCF12/HEB-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135514_2_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2279 CCLE Cell Line Gene CNV Profiles 1.0 2.4647 GSE174701_1_v_0_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.102338 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18595 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0126-SM-2XCFF GTEx Tissue Sample Gene Expression Profiles 1.0 0.887796 Nephrocalcinosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.537 HUG1N CCLE Cell Line Gene CNV Profiles 1.0 1.54158 TBK1 Pathway Commons Protein-Protein Interactions 1.0 null GSE74490_0_v_1_triptolide_mouse RummaGEO Drug Perturbation Signatures -1.0 null aniseikonia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.93468 MET_knockout_259_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.815805 YWHAH Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z4-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervix Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE158834_12_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null Palatine uvula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.666 NAP1L1 Pathway Commons Protein-Protein Interactions 1.0 null HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37299 PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX Rummagene Transcription Factor Associations 2026 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null lateral hypothalamic area, anterior region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10272 Perturb_6507_OE_PTEN_SRP299373 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.18589 CCNT1 Pathway Commons Protein-Protein Interactions 1.0 null DOK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.843234 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transition GeneRIF Biological Term Annotations 1.0 null PHF5A Pathway Commons Protein-Protein Interactions 1.0 null GSE238018_3_v_5_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.882693 GSE158834_1_v_5_palm_human RummaGEO Gene Perturbation Signatures -1.0 null GSE164874_5_v_0_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QDVJ-0726-SM-48U1W GTEx Tissue Sample Gene Expression Profiles 1.0 1.29093 Sarcoma_SARC_TCGA-IE-A4EH-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RIPK3 Kinase Library Serine Threonine Kinome Atlas 1.0 null Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.74005 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null MKN28 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.13169 AC-36-TL21_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.904741 KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362855 CTB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_15127_KO_Mettl3_SRP363779 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 embryonic fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.093868 SF767 DepMap CRISPR Gene Dependency 1.0 4.40279 HS-578-T COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 GSE158834_12_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F4-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-1426-SM-2TF4H GTEx Tissue Sample Gene Expression Profiles 1.0 0.854412 cingulate gyrus, parietal part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.910798 CSNK1E Hub Proteins Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-6290-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1-26981420-C2C12-MOUSE-MUSCLE ChEA Transcription Factor Targets 2022 1.0 null ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSMC4 Pathway Commons Protein-Protein Interactions 1.0 null GSE57871_6_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null WSU-DLCL2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AH-2026-SM-2S1PX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41395 organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.051123 Liver hepatocellular carcinoma_LIHC_TCGA-K7-AAU7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 18378853-TableS2 GeneSigDB Published Gene Signatures 1.0 null LD-69-ZV56_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.38394 BB-20-UU03_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.307075 G118 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.942809 GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.977708 RPS8 Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-7021-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1260b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 keratin filament GO Cellular Component Annotations 2025 1.0 null CF-50-QK79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.934404 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.53366 lower dorsal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16211 ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.3568 variation GeneRIF Biological Term Annotations 1.0 null PRPF3 Pathway Commons Protein-Protein Interactions 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Nucleus pulposus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.69 TCF7-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Osteosarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 GTEX-WYBS-0426-SM-3NM9M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24392 KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MVP Pathway Commons Protein-Protein Interactions 1.0 null prostate carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.157929 CTCF_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-0426-SM-3TW8V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.900532 CELF2 Pathway Commons Protein-Protein Interactions 1.0 null RRP12 Pathway Commons Protein-Protein Interactions 1.0 null CE-15-YU05_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.256999 MARK2 Pathway Commons Protein-Protein Interactions 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleolar ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.611 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBED4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 116.371 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00934 JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.836892 GDM-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.51252 GSE119694_1_v_0_lifr_mouse RummaGEO Gene Perturbation Signatures -1.0 null disease of metabolism GWASdb SNP-Disease Associations 1.0 0.099266 CBX1 Pathway Commons Protein-Protein Interactions 1.0 null RPL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01366 Perturb_6910_KD_KLF5_SRP091857 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.46266 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.69618 KRT10 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-2326-SM-2XCB4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10838 FAM83D Pathway Commons Protein-Protein Interactions 1.0 null KRT80 Pathway Commons Protein-Protein Interactions 1.0 null DA-33-BM26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.14451 Trabecula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.688 PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null Ameloblastoma DisGeNET Gene-Disease Associations 1.0 null BL324 (PMS2) NURSA Protein Complexes 1.0 null EIF3C Pathway Commons Protein-Protein Interactions 1.0 null PKN1 Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE110248_1_v_6_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237622 Stellate reticulum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.569 SEC16A Pathway Commons Protein-Protein Interactions 1.0 null CTCF_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metaphase_anaphase_telophase_15min_noscapine_release vs ctrl_HeLa (Human) [19691289] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs 1.0 null CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GIPC1 Pathway Commons Protein-Protein Interactions 1.0 null BE-27-RQ61_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300111 LXF-289 COSMIC Cell Line Gene Mutation Profiles 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171292_5_v_2_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null Dental caries DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.361 mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11476 beta-catenin destruction complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.295 SRRM1 Pathway Commons Protein-Protein Interactions 1.0 null PUM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE239844_6_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.47 FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.07314 KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878892 SCRIB Pathway Commons Protein-Protein Interactions 1.0 null RPL10A Pathway Commons Protein-Protein Interactions 1.0 null CTCF_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-2226-SM-3DB88 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08871 GSE206729_5_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null RPL13 Pathway Commons Protein-Protein Interactions 1.0 null CL14 CCLE Cell Line Gene CNV Profiles -1.0 -1.6538 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE200839,GSE233826_2_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null COV318 CCLE Cell Line Gene CNV Profiles -1.0 -2.33945 hsa-miR-3975 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06499 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.0023 Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CD-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null precuneus, right, superior lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.894955 CE-15-YU05_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222132 GSE189789_0_v_1_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null r7 part of the nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.40763 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null swiss-3t3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.41848 MCF7_Triamcinolone Acetonide_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014261 C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877561 GSE238018_3_v_2_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_10_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Veliparib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150938 adrenal gland HPA Tissue Protein Expression Profiles -1.0 -1.00299 anther TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.173104 WFDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01683 CTCF_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TPR Pathway Commons Protein-Protein Interactions 1.0 null r10 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74742 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18752 GSE96641_3_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null GTEX-T5JW-0426-SM-4DM7M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965071 BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220551 abnormal behavior MGI Mouse Phenotype Associations 2023 1.0 null AB-97-BI36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.975522 RUVBL1 Pathway Commons Protein-Protein Interactions 1.0 null GSE215086_0_v_2_batf_human RummaGEO Gene Perturbation Signatures 1.0 null MET_knockdown_254_GSE38343 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.47963 ECGI10 CCLE Cell Line Gene CNV Profiles -1.0 -1.57117 GSE158197_2_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null r9 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97957 GTEX-UPIC-1026-SM-4IHLT GTEx Tissue Sample Gene Expression Profiles 1.0 1.40811 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null C1QBP Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S95S-0426-SM-4B64I GTEx Tissue Sample Gene Expression Profiles 1.0 1.07636 keratins GeneRIF Biological Term Annotations 1.0 null KB-78-BE93_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271397 GTEX-XV7Q-2926-SM-4BRUL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12854 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08369 AC-36-TL21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.802518 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A498 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_5152_KD_Ell3_SRP013333 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.6585 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206729_4_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.529 SRY ChEA Transcription Factor Targets 1.0 null SF3B2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_0_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88292 amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61984 posteroventral (inferior) parietal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.857038 H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Hair shaft TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.804 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.9683 TUBA1B Pathway Commons Protein-Protein Interactions 1.0 null GSE190384,GSE190386_1_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.366339 GSE203181_0_v_1_phosphoramidon_human RummaGEO Drug Perturbation Signatures -1.0 null GSE189941_1_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures 1.0 null GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null Female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.556 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.82524 LRRC32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52963 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE120413,GSE120447_4_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null disassembly GeneRIF Biological Term Annotations 1.0 null GSE171292_1_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPL18A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XGQ4-1526-SM-4AT6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.33444 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COPB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59555 PLCE1 Pathway Commons Protein-Protein Interactions 1.0 null Rapamycin vs Ctrl_Exp2_MEFs (Mouse) [21659605] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TE-8 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872139 PRSS27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22329 GTEX-P4PP-0126-SM-3LK69 GTEx Tissue Sample Gene Expression Profiles 1.0 0.993012 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.887742 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.849691 Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92083 LS1034 DepMap CRISPR Gene Dependency 1.0 2.70968 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_ENMD-2076_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209372 GTEX-PWCY-2226-SM-2S1OP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31404 GTEX-S95S-1626-SM-2XCDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.265 PCCL-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.767 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null Retinoschisis_Retina_GSE5581 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 0.901262 RPL7A Pathway Commons Protein-Protein Interactions 1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 Periodontal ligament TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.993 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A75M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null kinase binding GO Molecular Function Annotations 2023 1.0 null LARS Pathway Commons Protein-Protein Interactions 1.0 null HSPB1 Pathway Commons Protein-Protein Interactions 1.0 null VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1617 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null GSE217452_2_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2941-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null UBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25092 abnormal kidney morphology IMPC Knockout Mouse Phenotypes 1.0 null MCF7_INO-1001_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161525 PAK4 Kinase Library Serine Threonine Kinome Atlas 1.0 null SPI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE213228_2_v_0_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null KURAMOCHI COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42615 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040565 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.874862 PMC3348545-NIHMS263168-supplement-3.pdf-196-ZFAT_ZFAT Rummagene Transcription Factor Associations 2026 1.0 null PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null Primary motor area, Layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10355 GTEX-T6MO-0526-SM-4DM6R GTEx Tissue Sample Gene Expression Profiles 1.0 1.09678 observed GeneRIF Biological Term Annotations 1.0 null Uterine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.475 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33583 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00833 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14278 KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.660599 Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null methotrexate_homo sapiens_gpl570_gse11440 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ILF2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XAJ8-1226-SM-47JYS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890808 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles 1.0 1.73524 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09906 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BA-26-GI09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251432 DBR1 Pathway Commons Protein-Protein Interactions 1.0 null GSE96649_1_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Uterine disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.471 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.079157 GSE88819_5_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.296 GSE161800_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41027 KLB Pathway Commons Protein-Protein Interactions 1.0 null abnormal cholesterol homeostasis MGI Mouse Phenotype Associations 2023 1.0 null FECH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07816 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.956 GSE214725_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null TRIM21 Pathway Commons Protein-Protein Interactions 1.0 null GSE169697,GSE169725_1_v_4_prrx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Keratin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.403 GSE140607_1_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33869 H3K4ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null STK3 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Enzastaurin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015396 WM88_SKIN CCLE Cell Line Proteomics 1.0 2.68969 OCIMY5 CCLE Cell Line Gene CNV Profiles 1.0 1.33002 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.77385 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.951677 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7015-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE180185_4_v_1_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE174498,GSE174500_3_v_4_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-190-ZNF707_ZNF707 Rummagene Transcription Factor Associations 2026 1.0 null skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -1.00299 COPA Pathway Commons Protein-Protein Interactions 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE105170,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null GSE135030_11_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null SUP-HD1 COSMIC Cell Line Gene Mutation Profiles 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.02805 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09857 AURKB Pathway Commons Protein-Protein Interactions 1.0 null AD-18-XC14_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.594211 Huntington's Disease_CNS - Brain (MMHCC)_GSE857 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.50823 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849773 UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.76904 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung function (FEV1/FVC) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.530103 Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18485 H3K14ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902542 GTEX-OOBJ-1826-SM-3NB1C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963624 decreased exploration in new environment IMPC Knockout Mouse Phenotypes 1.0 null MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8926 CTCF_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE205976,GSE205978_3_v_0_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null CF-24-KQ98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.443111 r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98118 mitochondrial outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.175745 refractive error DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.275445 RCN2 Pathway Commons Protein-Protein Interactions 1.0 null ERCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67397 Lung adenocarcinoma_LUAD_TCGA-73-7498-01A-12R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE81803,GSE81912_0_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MZT2A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XYKS-1526-SM-4BRUP GTEx Tissue Sample Gene Expression Profiles 1.0 1.18129 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10273062-JCMM-27-1708-s001.xlsx-Sheet_1-CESC_AND_UCS_NOT_BRCA_NOT_UCEC_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null p1 portion of the paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07252 SNRPE Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.47275 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054674 GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0947 GSE139455_4_v_6_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null QE-79-XO29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247432 abnormal oral cavity morphology MGI Mouse Phenotype Associations 2023 1.0 null NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08231 primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.847918 SMC3 ENCODE Transcription Factor Targets 1.0 null stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.906969 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12524 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.944117 CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null jaw TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.16573 H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27379 GSE104022_3_v_7_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 isthmic portion of paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00738 Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.387 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26712 TE-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35398 PMC7581777-41419_2020_3029_MOESM6_ESM.xlsx-MNX1_ChIP-Symbol_MNX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XUJ4-1026-SM-4BOPB GTEx Tissue Sample Gene Expression Profiles 1.0 1.30766 MCF7_TG101209_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0108528 TRIM33 Pathway Commons Protein-Protein Interactions 1.0 null ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE158834_0_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null kinase binding GO Molecular Function Annotations 2025 1.0 null GSE135030_11_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null BE-31-XV38_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.452166 Perturb_8995_KO_RGCC_SRP316360 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.8491 NUDC Pathway Commons Protein-Protein Interactions 1.0 null primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.824176 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6493-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE161170,GSE161268_0_v_2_med1_human RummaGEO Gene Perturbation Signatures 1.0 null CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36944 IQCB1 Pathway Commons Protein-Protein Interactions 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTDH_DEPLETION_GDS3179_98_human_LM2 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_128_KD_Cebpb_SRP041765 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.01675 DARS Pathway Commons Protein-Protein Interactions 1.0 null r7 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03844 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day4_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.0039 HES5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8045 GSE216043_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null brachyolmia-amelogenesis imperfecta syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.284 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0445 GCN1L1 Pathway Commons Protein-Protein Interactions 1.0 null GSE233679_6_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.048 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12047 FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09802 ZIC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 101.997 GSE158834_12_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.597454 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null K562_CEP-33779_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0330221 largeintestine BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.845524 OGT Pathway Commons Protein-Protein Interactions 1.0 null B-CPAP Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.77172 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.913654 RPL14 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_12_v_9_palm_human RummaGEO Gene Perturbation Signatures -1.0 null SREBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.16327 GSE242083,GSE242098_3_v_5_med1_human RummaGEO Gene Perturbation Signatures -1.0 null BE2-M17 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.327 A549_SB431542_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0296434 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16209 GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53638 Renal hypomagnesemia 5 with ocular involvement DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.114 DIAPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04188 KYM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.528062 MCF7_AG-490_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0191397 Lung squamous cell carcinoma_LUSC_TCGA-77-6844-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H520 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q734-1626-SM-48U1B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831164 H2AFZ ENCODE Transcription Factor Targets 1.0 null GTEX-R53T-2026-SM-3GIJF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 MAP2 Pathway Commons Protein-Protein Interactions 1.0 null CDX2-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X62O-1626-SM-46MW9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27726 GSE171572_3_v_4_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null Germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.977 CTCF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WQUQ-0426-SM-3MJFU GTEx Tissue Sample Gene Expression Profiles 1.0 0.997254 SRP14 Pathway Commons Protein-Protein Interactions 1.0 null encode GeneRIF Biological Term Annotations 1.0 null K562_AT9283_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158666 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC16A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12157 SF3B3 Pathway Commons Protein-Protein Interactions 1.0 null YBX1 Pathway Commons Protein-Protein Interactions 1.0 null BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.22104 GSE192771_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE211474,GSE212779_0_v_1_phf8_human RummaGEO Gene Perturbation Signatures -1.0 null L-363 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.52672 UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841846 tooth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.31018 RPL27 Pathway Commons Protein-Protein Interactions 1.0 null GA-94-MC54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230197 abnormality of carbohydrate metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.198319 TCF7L2 ENCODE Transcription Factor Targets 1.0 null ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.6659 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WH7G-0926-SM-4LVMJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17182 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NARF Pathway Commons Protein-Protein Interactions 1.0 null G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1154 mitochondrial part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048627 GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCN1 Pathway Commons Protein-Protein Interactions 1.0 null enterocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.83448 K562_JNJ-26854165_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.01448 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VJ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE240896,GSE240899_10_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SUCS-1926-SM-32PM3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04075 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 Mesothelioma_MESO_TCGA-LK-A4NW-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.68453 periventricular stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57184 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number IMPC Knockout Mouse Phenotypes 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.968311 RAD50 Pathway Commons Protein-Protein Interactions 1.0 null GSE134191_3_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNPC3 Pathway Commons Protein-Protein Interactions 1.0 null DA-19-JA87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.482072 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE186810,GSE186813_3_v_5_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XAJ8-1426-SM-47JYM GTEx Tissue Sample Gene Expression Profiles 1.0 0.928696 GPR98 Pathway Commons Protein-Protein Interactions 1.0 null Tooth enamel TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 3.09 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SOX2-20726797-SW620-HUMAN ChEA Transcription Factor Targets 2022 1.0 null AC-36-TL21_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.4758 CAL120 CCLE Cell Line Gene CNV Profiles -1.0 -1.4787 GNAI3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-TML8-1126-SM-4DXSS GTEx Tissue Sample Gene Expression Profiles 1.0 1.03367 A549_Raltitrexed_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106929 IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE158834_11_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null PMC5013636-ncomms12601-s5.xlsx-TCF3-Groups_TCF3 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.14321 members GeneRIF Biological Term Annotations 1.0 null H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermediate stratum of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16825 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOD1_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Selisistat_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163289 RAD21_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.161494 YWHAZ Pathway Commons Protein-Protein Interactions 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937293 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.98641 Right_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.859185 Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF3E Pathway Commons Protein-Protein Interactions 1.0 null 18818702-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null MZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14443 GSE244233_1_v_0_quercetin_human RummaGEO Drug Perturbation Signatures -1.0 null SNU216 CCLE Cell Line Gene CNV Profiles 1.0 1.46008 abnormal heart morphology IMPC Knockout Mouse Phenotypes 1.0 null GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HUH-6-CLONE5 COSMIC Cell Line Gene Mutation Profiles 1.0 null SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Amelogenesis imperfecta type 1E DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 YA-78-MS95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.413934 Rennet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.974 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pseudostem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.503 Perturb_4549_KD_Hdac6_SRP126769 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.32931 KLF7_KO_GDS2069_68_mouse_olfactory epithelia GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null OVCA433 COSMIC Cell Line Gene Mutation Profiles 1.0 null SUP-B15 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.50353 MYH9 Pathway Commons Protein-Protein Interactions 1.0 null GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.08 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044406 Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.39 Secondary root TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.788 ACOX1 Pathway Commons Protein-Protein Interactions 1.0 null GSE193258,GSE193259_5_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTF2I Pathway Commons Protein-Protein Interactions 1.0 null RBM41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09745 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 17192395-TableS2c GeneSigDB Published Gene Signatures 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null TUBB3 Pathway Commons Protein-Protein Interactions 1.0 null GSE228106_3_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8580-01A-31R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193258,GSE193259_5_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE109111_2_v_0_stim1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213228_1_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42229 GTEX-R55C-1826-SM-3GADI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22048 PMC11653668-ADVS-11-2400133-s005.pdf-8-THAP11_THAP11 Rummagene Transcription Factor Associations 2026 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19905 SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null K562_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149791 GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14322 CELF1 Pathway Commons Protein-Protein Interactions 1.0 null Cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FOS ENCODE Transcription Factor Targets 1.0 null keratin filament binding GO Molecular Function Annotations 2023 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHUK Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165560_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null NME2P1 Pathway Commons Protein-Protein Interactions 1.0 null dorsal terminal nucleus of the accessory optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29124 g.8 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.619 DCD Pathway Commons Protein-Protein Interactions 1.0 null IC-05-AW29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.388941 KPNYS DepMap CRISPR Gene Dependency 1.0 3.20845 GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944499 CB-87-RB49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.686371 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NACAP1 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3176 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 PTGES3 Pathway Commons Protein-Protein Interactions 1.0 null OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10338 MFE-280 COSMIC Cell Line Gene Mutation Profiles 1.0 null NAT10 Pathway Commons Protein-Protein Interactions 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null NANOG ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EA-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178532_2_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.734 JD-62-HR05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.297019 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7229-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Prednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137123 MFGE8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50533 DA-27-BW40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.408991 SP1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE139455_4_v_3_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RANGAP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_12_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8073-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8176-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8483 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null esophagus_5b HPA Tissue Sample Gene Expression Profiles 1.0 0.914334 TTC4 Pathway Commons Protein-Protein Interactions 1.0 null FC-20-EQ58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.35503 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.755353 CTCF_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-1026-SM-48FDI GTEx Tissue Sample Gene Expression Profiles 1.0 1.21286 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13529 GSK3B Pathway Commons Protein-Protein Interactions 1.0 null DC-47-KV62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.589064 GSE246911,GSE246913_4_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.285388 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of cardiac morphology GWASdb SNP-Phenotype Associations 1.0 0.6209 HTATSF1 Pathway Commons Protein-Protein Interactions 1.0 null Mafb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.4568 Erythroleukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-W5WG-1626-SM-4LMKG GTEx Tissue Sample Gene Expression Profiles 1.0 1.26995 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE209938_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.488299 biomineral tissue development GO Biological Process Annotations 2015 1.0 null Heimler syndrome 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.573 DDR1 Pathway Commons Protein-Protein Interactions 1.0 null chr8_143779569_CTCAT_C_b38 GTEx eQTL 2025 1.0 1.22605 GTEX-OOBK-0625-SM-3LK5P GTEx Tissue Sample Gene Expression Profiles 1.0 1.50889 EP300 ENCODE Transcription Factor Targets 1.0 null HELA COSMIC Cell Line Gene Mutation Profiles 1.0 null BF-49-QA17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237062 Perturb_14322_KD_XPR1_SRP347870 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.84055 alveolar bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.511384 abnormal coat appearance IMPC Knockout Mouse Phenotypes 1.0 null GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827196 GSE151612_4_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11625982-AJH-100-10-s001.pdf-26-ZNF682_ZNF682 Rummagene Transcription Factor Associations 2026 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2C2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPI Pathway Commons Protein-Protein Interactions 1.0 null RPS7 Pathway Commons Protein-Protein Interactions 1.0 null GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Amelogenesis Imperfecta CTD Gene-Disease Associations 1.0 2.88009 previously GeneRIF Biological Term Annotations 1.0 null sirolimus_mus musculus_gpl1261_gse21755 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE67266_7_v_3_etoposide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE160083,GSE160084_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null first GeneRIF Biological Term Annotations 1.0 null SARS-CoV MA15_Day7-PFU-10^5_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.49884 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.3113 Gastrointestinal system disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 POU3F1-26484290-ESCSS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88583 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24058 Leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RPL38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04833 RXRA-24833708-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_1223_KD_ACIN1_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.11717 superior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.67404 GSE57871_5_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE252857_2_v_3_klf15_mouse RummaGEO Gene Perturbation Signatures 1.0 null Photoreceptor proximal connecting cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.968 amblyopia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.753306 CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPL30 Pathway Commons Protein-Protein Interactions 1.0 null RPL18 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased circulating potassium level IMPC Knockout Mouse Phenotypes 1.0 null PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02775 cerebellar cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07402 GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKN2 Kinase Library Serine Threonine Kinome Atlas 1.0 null PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.16662 M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24981 Mandible TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.671 CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null 18787218-tableS1 GeneSigDB Published Gene Signatures 1.0 null F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 4.44014 SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4094 SF3A1 Pathway Commons Protein-Protein Interactions 1.0 null parathyroid gland HPA Tissue Protein Expression Profiles -1.0 -1.00299 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21534 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.298883 PSMC1 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Motesanib Diphosphate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155395 r10 part of vagal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12467 abnormality of dental structure HPO Gene-Disease Associations 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869232 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.223497 Neoplasm Metastasis DisGeNET Gene-Phenotype Associations 1.0 null GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE239844_11_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H446 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VJYA-1126-SM-3GIJU GTEx Tissue Sample Gene Expression Profiles 1.0 0.928127 Perturb_7611_KD_PARP1_SRP410217 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Perturb_17802_KO_ZNF675_SRP305529 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.75363 inner SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.833437 CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null formation GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AG-0526-SM-2S1PW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15427 GA-77-MH38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212471 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A4XB-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1428 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.438625 E2A MotifMap Predicted Transcription Factor Targets 1.0 null protein localization to cytoskeleton GO Biological Process Annotations 2025 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4EO-0326-SM-3P5YO GTEx Tissue Sample Gene Expression Profiles 1.0 0.876672 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 Bed nuclei of the stria terminalis, anterior division, anteromedial area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05686 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.969128 CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3689c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 JMJD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02303 GSE111035,GSE111040_3_v_13_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18835 Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37564 VA-48-RJ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.937342 GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles 1.0 1.37389 Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.322 GSE193993_1_v_2_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null TCF12_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05335 496100415_PCx_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04897 phenotypes GeneRIF Biological Term Annotations 1.0 null BT-20 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971903 posteroventral (inferior) parietal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38236 WM793B COSMIC Cell Line Gene Mutation Profiles 1.0 null small testis MGI Mouse Phenotype Associations 2023 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8591 striatum_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45244 CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.26106 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27053 HuO9 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.60801 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0426-SM-2XCFH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62859 MCF7_RG108_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144011 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.890989 LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.704819 PMC8045971-Table_3.xlsx-vs_LPS_ctrl-Unnamed_4_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03456 KARS Pathway Commons Protein-Protein Interactions 1.0 null GSE203017_0_v_1_irs2_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-1268 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 RT11284 CCLE Cell Line Gene Expression Profiles 1.0 1.36833 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.75762 GTEX-P4QS-0626-SM-3NMD1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01245 Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28688 H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KRT7 Pathway Commons Protein-Protein Interactions 1.0 null Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.551619 GTEX-TKQ1-1026-SM-4GICL GTEx Tissue Sample Gene Expression Profiles 1.0 1.14491 RPS16 Pathway Commons Protein-Protein Interactions 1.0 null PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.12013 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE103068_5_v_4_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null MYH2 Pathway Commons Protein-Protein Interactions 1.0 null GSE193258,GSE193259_5_v_8_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2814 CCLE Cell Line Gene Expression Profiles 1.0 1.61238 HT115 DepMap CRISPR Gene Dependency 1.0 5.12052 TSR1 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-7031-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NOP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46304 PMC7338542-41389_2020_247_MOESM5_ESM.xlsx-BRN2_2_of_3_UP_48_h-Symbol_POU3F2 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null P4E6 DepMap CRISPR Gene Dependency 1.0 4.09192 TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.4122 HA-E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NTERA2CLD1 DepMap CRISPR Gene Dependency 1.0 2.87246 G84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.897906 SNRPA1 Pathway Commons Protein-Protein Interactions 1.0 null Embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Dental fluorosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.653 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03682 GTEX-W5WG-1326-SM-4LMI9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858145 GTEX-VUSG-1226-SM-4KKZF GTEx Tissue Sample Gene Expression Profiles 1.0 1.0553 Bed nuclei of the stria terminalis, posterior division, transverse nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15772 GTEX-OIZG-0726-SM-33HBL GTEx Tissue Sample Gene Expression Profiles 1.0 0.954118 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5169 Perturb_15718_OE|KD_Ctcf|Smarca5_SRP173291 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.34147 CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_2_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null bed nucleus of the stria terminalis, medioseptal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14397 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE131649_4_v_3_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null r2 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3746 CTCF_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null HPAC CCLE Cell Line Gene Expression Profiles 1.0 1.38262 HES6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8015 PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NA-16-OJ70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.349384 Tongue epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.772 Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.131 Amelogenesis imperfecta type 1B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.342 Anchored component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.844 regulation of cell migration GO Biological Process Annotations 2023 1.0 null GTEX-S33H-2426-SM-2XCB2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16822 GTEX-T8EM-0526-SM-4DM64 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36086 GSE223241_1_v_3_cdkn2a_human RummaGEO Gene Perturbation Signatures -1.0 null NCIH2081 CCLE Cell Line Gene CNV Profiles -1.0 -1.67403 central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.060535 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN Rummagene Transcription Factor Associations 2026 1.0 null TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 138.265 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3749 Retinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.512 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02116 Head and neck carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 LXF289 DepMap CRISPR Gene Dependency 1.0 2.31323 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-N7MT-0326-SM-48TDP GTEx Tissue Sample Gene Expression Profiles 1.0 1.29045 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Dental plaque TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.916 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GNAI1 Pathway Commons Protein-Protein Interactions 1.0 null A549_PD173074_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139014 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14243 GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12848 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PRKAA1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null retropontine reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2514 Cytosol COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.956 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.632 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YKG-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.71965 Oral epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.118 GSE216352,GSE216354_1_v_0_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null SNU668 CCLE Cell Line Gene CNV Profiles 1.0 1.3916 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2733 GSE208096_1_v_0_progesterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09823 GSE227698_2_v_1_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GAMG_CENTRAL_NERVOUS_SYSTEM CCLE Cell Line Proteomics 1.0 2.85577 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EEIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08574 GSE106661,GSE106665_2_v_3_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null KC-32-GO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.237933 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null iPS-20b Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.55483 Acute Myeloid Leukemia_LAML_TCGA-AB-2918-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8481886-Table_1.xlsx-A_subsets-iMSC_UC_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null imperfecta GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AI-0626-SM-48TZU GTEx Tissue Sample Gene Expression Profiles 1.0 1.33378 CEP97 Pathway Commons Protein-Protein Interactions 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.386979 RERF-GC-1B COSMIC Cell Line Gene Mutation Profiles 1.0 null SMARCB1 ENCODE Transcription Factor Targets 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DC-47-KV62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.06354 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.69183 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10619 AIMP2 Pathway Commons Protein-Protein Interactions 1.0 null GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100511_TCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.07845 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-1126-SM-4BRVS GTEx Tissue Sample Gene Expression Profiles 1.0 0.923919 SNRPB2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A820-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EIF3L Pathway Commons Protein-Protein Interactions 1.0 null AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.22113 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.986 PRKDC Pathway Commons Protein-Protein Interactions 1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null CDC14A Pathway Commons Protein-Protein Interactions 1.0 null bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.46773 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4h_cisplatin vs ctrl_mESC (Mouse) [22006019] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs 1.0 null USP19 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S33H-0826-SM-4AD5Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.58289 Necrosis CTD Gene-Disease Associations 1.0 1.26825 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior cingulate area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15772 Perturb_2855_Mut_SPOP_SRP404927 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.57983 DYRK2 Kinase Library Serine Threonine Kinome Atlas 1.0 null MIAPACA2 DepMap CRISPR Gene Dependency 1.0 2.43405 GTEX-U3ZH-1726-SM-3DB79 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26136 abnormal coat/ hair morphology MGI Mouse Phenotype Associations 2023 1.0 null dorsal part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01654 NEDD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62511 hsa-miR-324-5p MiRTarBase microRNA Targets 1.0 null CROCC Pathway Commons Protein-Protein Interactions 1.0 null EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.293019 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null krt7_21596846_megakaryocyte_progenitor_bone_marrow_lof_mouse_gpl6105_gse24969 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.208367 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLK4 Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE92589_0_v_1_sirolimus_mouse RummaGEO Drug Perturbation Signatures 1.0 null subiculum, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17124 A549_Capecitabine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015174 GTEX-X4EP-0826-SM-3P5YK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.900793 JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.815201 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.069 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842488 GTEX-QV44-2226-SM-447A3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33353 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A183-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skin HPA Tissue Gene Expression Profiles 1.0 1.37618 TBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1914 H3K36me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null oral mucosa HPA Tissue Protein Expression Profiles 1.0 1.62621 small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.200306 Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_11_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null last GeneRIF Biological Term Annotations 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Perturb_4971_KD_Mthfd2_SRP149554 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.47698 CB-32-EI69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.54234 GSE158834_12_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52093 Mandibular incisor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.022 GTEX-PWCY-1726-SM-48TD3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.119 GSE127790_5_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47869 KINGS1 DepMap CRISPR Gene Dependency 1.0 3.16841 BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.398222 NONO Pathway Commons Protein-Protein Interactions 1.0 null PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null NCIH660 CCLE Cell Line Gene CNV Profiles 1.0 1.38122 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.941266 sublayer 6a of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08872 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5WG-1826-SM-4KL2Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.909446 MCF7_Tofacitinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145318 CC-70-BD07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.317277 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKN3 Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE120248,GSE120252_1_v_0_macf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC1195 CCLE Cell Line Gene CNV Profiles 1.0 1.32794 TOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48346 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.828724 Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.84456 GTEX-XUW1-0726-SM-4BOP5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94632 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.531754 Pavement epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.02 mantle zone of PcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77592 PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null parasubthalamic nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18312 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25428 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01409 NCI-H1688 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-5853-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HERC1 Pathway Commons Protein-Protein Interactions 1.0 null ZB-72-PE17_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.388265 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82011 abnormality of dental enamel HPO Gene-Disease Associations 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.86569 EZH2-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE155852_0_v_1_apigenin_mouse RummaGEO Drug Perturbation Signatures 1.0 null inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59346 GTEX-X62O-2226-SM-46MW3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.78738 PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null MCF7_AG-490_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0226498 MAFK ENCODE Transcription Factor Targets 1.0 null K562_Vandetanib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163907 GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-YC-A89H-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UACC812 CCLE Cell Line Gene Expression Profiles 1.0 2.1615 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174751_0_v_1_postn_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null DYNC1H1 Pathway Commons Protein-Protein Interactions 1.0 null r4 part of pontine raphe cell population Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31698 GSE136894_1_v_0_psen1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_8_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18286 GSE158834_12_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3Y4-01A-51R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE227592_8_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GSE184892_6_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null GSE240027,GSE240030_5_v_0_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE256181_2_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null ATF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13924 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.755565 SNAP23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14079 amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.994889 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 1.50143 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal testis morphology IMPC Knockout Mouse Phenotypes 1.0 null GSE131649_4_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12738 OAW42 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null RPL17 Pathway Commons Protein-Protein Interactions 1.0 null Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.441 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.872237 lateral preoptic nucleus, PO2 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34985 TT2609-C02 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.13645 CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSNK1D Pathway Commons Protein-Protein Interactions 1.0 null Retrosplenial area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77118 AP2M1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_6795_Mut_MYC_SRP060721 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.10285 MZT2B Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Clevudine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155573 CTCF_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDKN2AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11716 GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.555786 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL31 Pathway Commons Protein-Protein Interactions 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_17806_KO_ZNF675_SRP304971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.75363 lateral part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16563 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.517284 HNRNPR Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OXRL-1826-SM-2YUMV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 GTEX-T5JW-0726-SM-4DM6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.944449 XPC Pathway Commons Protein-Protein Interactions 1.0 null UBE3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16974 SOX2-20726797-SW620-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.966954 YD10B CCLE Cell Line Gene Expression Profiles 1.0 1.78166 Psoas_Muscle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.50372 Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.8734 LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.944791 Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70124 GSE202434,GSE202438_12_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.091647 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02779 FLII Pathway Commons Protein-Protein Interactions 1.0 null PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA Rummagene Transcription Factor Associations 2026 1.0 null microvillus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.324576 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.09815 SKA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47899 VEXAS syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 PAX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.762 CCDC77 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DYRK1B Kinase Library Serine Threonine Kinome Atlas 1.0 null ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2243 GSE240027,GSE240030_1_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26278 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02106 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.644 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.988905 CCT6A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XMK1-1326-SM-4B65Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.02926 NGLY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69947 MZ in posteroventral (inferior) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.77997 DVL2 Pathway Commons Protein-Protein Interactions 1.0 null medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.37468 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.21497 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.948134 Ruffle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.212 GSE225762_1_v_0_pcmt1_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A87H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23082 S0-EE-Y737_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242409 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.73126 ETS1 ENCODE Transcription Factor Targets 1.0 null IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12495 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198794_2_v_3_usp18_human RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.969916 PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.0949 GTEX-X261-0126-SM-3NMD6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.877825 EGR1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSNK1A1 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_0_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null r6 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53586 AHSA1 Pathway Commons Protein-Protein Interactions 1.0 null teeth hard tissue disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GSE253041_1_v_0_ramp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null spleen HPA Tissue Protein Expression Profiles -1.0 -1.00299 GSE224004,GSE224005_0_v_8_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWN1-0126-SM-2I3FK GTEx Tissue Sample Gene Expression Profiles 1.0 1.06344 Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Superior central nucleus raphe, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26439 NCL Pathway Commons Protein-Protein Interactions 1.0 null Ectodermal dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 CLSPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38163 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.850517 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dentin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.248 PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoproteome_AKT1_KD_vs_SCR-Unnamed_3_AR Rummagene Transcription Factor Associations 2026 1.0 null RPL10 Pathway Commons Protein-Protein Interactions 1.0 null DYRK3 Kinase Library Serine Threonine Kinome Atlas 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.874875 MCF7_G007-LK_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0121519 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLEC Pathway Commons Protein-Protein Interactions 1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00781 TB-06-VB30_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252564 MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM2B-26808549-CHIP-SEQ-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null G-361 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.846 DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.09972 GSE130081,GSE130082_0_v_10_neil2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7069-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-7710-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158632_3_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5273-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 GSE185944_0_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.28291 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE130956_0_v_3_icaritin_human RummaGEO Drug Perturbation Signatures 1.0 null Dental follicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.954 CAL-85-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null K052 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.97826 CTCF_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-1426-SM-4BRUO GTEx Tissue Sample Gene Expression Profiles 1.0 0.906316 lateral septal nucleus, intermediate part, periventricular Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39882 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.718393 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.032811 Gonadal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 GSE210770_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201523 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.995565 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03672 SARM_KO_GDS4842_412_mouse_brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null USF MotifMap Predicted Transcription Factor Targets 1.0 null FAM83B Pathway Commons Protein-Protein Interactions 1.0 null nonsense GeneRIF Biological Term Annotations 1.0 null NCI-H1869 COSMIC Cell Line Gene Mutation Profiles 1.0 null NME1 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7149-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SP5_SP5 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Ki16425_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151513 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246567_0_v_1_acat2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WHSE-0126-SM-3NMBT GTEx Tissue Sample Gene Expression Profiles 1.0 0.829364 MCF7_MLN8054_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0109967 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PRKCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09139 H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Dentin dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.974 colorectal GeneRIF Biological Term Annotations 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.405 Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39387 GSE137818_5_v_6_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-7771-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DE-81-PO11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311704 PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_17548_KD_HMGN5_SRP354633 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 MYOD1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVUS-0626-SM-447CC GTEx Tissue Sample Gene Expression Profiles 1.0 1.50489 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.90317 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.63538 FLOT2 Pathway Commons Protein-Protein Interactions 1.0 null JiyoyeP-2003 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.89632 fivegeneration GeneRIF Biological Term Annotations 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04112 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE165122_0_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null A253 CCLE Cell Line Gene Expression Profiles 1.0 1.40147 TTN Pathway Commons Protein-Protein Interactions 1.0 null GSE96641_1_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38115 CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.844574 GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902302 ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_UNC0379_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179285 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VM-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT2_02_18 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58717 AE-14-NN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.678407 intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 STK4 Pathway Commons Protein-Protein Interactions 1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-XQ3S-1426-SM-4BOPR GTEx Tissue Sample Gene Expression Profiles 1.0 0.954996 GTEX-T2IS-0826-SM-4DM6L GTEx Tissue Sample Gene Expression Profiles 1.0 1.3436 Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ME-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 84.4625 KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24256 EC-62-OE64_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.876183 GSE228125_2_v_1_ptafr_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HNF4G_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-1626-SM-48TC9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41103 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B4-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29119 FOXA2 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8511-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14322 GSE65617_5_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_unique_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1944 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.8765 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5434 CEP85 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01534 JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERA-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.869117 GTEX-X5EB-2626-SM-4E3HZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21345 Brain Lower Grade Glioma_LGG_TCGA-HT-A616-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior cingulate area, ventral part, 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57193 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SC-185 (BCL3) NURSA Protein Complexes 1.0 null AP2A1 Pathway Commons Protein-Protein Interactions 1.0 null JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null enamel GeneRIF Biological Term Annotations 1.0 null CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4722-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAB5IF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04395 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31784 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CAL-12T COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null trigeminal BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.20432 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127790_11_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-7023-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.55022 GSE179880_10_v_3_e2f4_mouse RummaGEO Gene Perturbation Signatures 1.0 null NT5DC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00574 NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null FD-62-ZB67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.560687 GTEX-UPJH-0226-SM-3GADV GTEx Tissue Sample Gene Expression Profiles 1.0 1.04656 CAMK2G Pathway Commons Protein-Protein Interactions 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37299 CTCF_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56707 GSE195568_3_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS3 Pathway Commons Protein-Protein Interactions 1.0 null GSE174701_5_v_2_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null Kohlschutter-Tonz syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.322 DA-35-DU85_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201699 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.83771 PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.40366 primary auditory cortex (core)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10994 MCF7_Pelitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014868 GSE158834_12_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE111102,GSE111105_3_v_5_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.731004 HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null PML ENCODE Transcription Factor Targets 1.0 null RPL19 Pathway Commons Protein-Protein Interactions 1.0 null superficial stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53466 TMEM33 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5466-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNRNPL Pathway Commons Protein-Protein Interactions 1.0 null bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.928328 Lung squamous cell carcinoma_LUSC_TCGA-94-A4VJ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QCQG-0626-SM-48U21 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29693 GSE57871_8_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null TCF7 ChEA Transcription Factor Targets 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Buccal epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.095 PMC6207925-CDEV-89-1839-s001.xlsx-Table_4_FDR_hits_ODD_H_ADHD-Unnamed_2_OSR1 Rummagene Transcription Factor Associations 2026 1.0 null GSE96641_5_v_2_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null LJI308_SW1417 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00496364 r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37564 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null glucose GAD Gene-Disease Associations 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.65761 PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3 Rummagene Transcription Factor Associations 2026 1.0 null globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.073 intermediate stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.19494 TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169697,GSE169725_0_v_5_prrx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-1224-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 JF-96-HH81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251819 Bed nuclei of the stria terminalis, posterior division, strial extension Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45477 pollen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.243294 YY1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-1260 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE180185_4_v_8_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null BAG2 Pathway Commons Protein-Protein Interactions 1.0 null CCR4-NOT core complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.519 Arsenic CTD Gene-Chemical Interactions 1.0 null CUL2 Pathway Commons Protein-Protein Interactions 1.0 null eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.072915 ELF5-23300383-T47D-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K36me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AHCYL2 Pathway Commons Protein-Protein Interactions 1.0 null GSE199644_3_v_2_palmitic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null BE-73-KD75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21127 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.318042 Perturb_12993_KO_Il1rl1_SRP274117 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.56337 SHMAC4 DepMap CRISPR Gene Dependency 1.0 7.576 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7043_KO_miR17/miR20a/miR92a1_SRP050491 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.72948 GSE121198,GSE129782_1_v_0_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null GTEX-SIU8-0426-SM-4BRUE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891147 type 2 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.720744 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041513 FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ovary_8a HPA Tissue Sample Gene Expression Profiles -1.0 -1.21711 hsa-miR-4675 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.298 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15008 skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055242 uterus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null abnormal testis morphology MGI Mouse Phenotype Associations 2023 1.0 null NHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.746 skin_5f HPA Tissue Sample Gene Expression Profiles 1.0 1.0054 CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.628916 cytosol COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 lung HPA Tissue Protein Expression Profiles -1.0 -1.00299 Squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.515 CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19787 AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27137 FARP2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-NFK9-1126-SM-3LK78 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50417 CB-32-EI69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.260345 Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IQGAP1 Pathway Commons Protein-Protein Interactions 1.0 null keratoconjunctivitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.296571 AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210779 cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.263485 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.997376 DC-47-KV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.891418 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.548872 TAB2 Pathway Commons Protein-Protein Interactions 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETX Pathway Commons Protein-Protein Interactions 1.0 null RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16158 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2782-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE244072_10_v_8_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE89018_1_v_14_cry2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 abnormal coat appearance MGI Mouse Phenotype Associations 2023 1.0 null GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37385 GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13649 GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26161 SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.957647 GTEX-WOFM-1726-SM-3MJFA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941529 HSC1 DepMap CRISPR Gene Dependency 1.0 2.24395 PMC7397849-supp_gad.338681.120_Supplemental_Table_S1.xlsx-S1L_Shared_genes_3way_overlap-Suppl_Table_S1L_Shared_genes_between_YAP1-MAMLD1_YAP1-FAM118B_YAP1-TFE3_in_vitro_human_samples_TFE3 Rummagene Transcription Factor Associations 2026 1.0 null RPS25 Pathway Commons Protein-Protein Interactions 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null abnormality of the teeth HPO Gene-Disease Associations 1.0 null BT12 DepMap CRISPR Gene Dependency 1.0 2.22915 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCCIT Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.46187 protein localization to organelle GO Biological Process Annotations 2023 1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04192 Tooth TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.601 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.879227 PMC5998130-41467_2018_4619_MOESM10_ESM.xlsx-OHT_ESR1-Unnamed_2_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.32236 stamen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.151401 positive regulation of cell motility GO Biological Process Annotations 2025 1.0 null MET_knockout_257_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.953588 BICR16 DepMap CRISPR Gene Dependency 1.0 2.99696 HIST1H1E Pathway Commons Protein-Protein Interactions 1.0 null NCIH23 DepMap CRISPR Gene Dependency 1.0 2.21939 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MC-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-hREPC_AND_AF_MSC_AND_UM51_MSC Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null families GeneRIF Biological Term Annotations 1.0 null stat3_18070348_alveolar_type_2_epithelial_lof_mouse_gpl1261_gds3106 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.0907 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S7-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Luminespib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015017 irf6_17041601_skin_lof_mouse_gpl1261_gds2359 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.89292 Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 55.5188 primary motor-sensory cortex (samples)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17314 VZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33817 infratentorial cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.127763 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.536802 tooth GeneRIF Biological Term Annotations 1.0 null Perturb_4280_KO_Smchd1_SRP134966 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.21008 GSE88819_5_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nucleus accumbens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33096 MCF7_Celecoxib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014706 GSE193351_1_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE60837_6_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null MZ2-MEL Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.50452 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902542 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Jalili syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.415 Perturb_16511_KD_PAX9_SRP300302 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 hsa-miR-1227 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3991_KD_Zeb1_ERP109420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.13717 NCIH524 CCLE Cell Line Gene Expression Profiles -1.0 -1.46602 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ3S-0126-SM-4BOO9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27169 VPS33B Pathway Commons Protein-Protein Interactions 1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.10015 GSE60217_1_v_0_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null RPL15 Pathway Commons Protein-Protein Interactions 1.0 null odontoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.345928 K562_Valproic acid sodium salt_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.024222 19429869-TableS1 GeneSigDB Published Gene Signatures 1.0 null NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.96278 Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30195 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18496 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null decreased locomotor activity MGI Mouse Phenotype Associations 2023 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -1.72097 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null severe GeneRIF Biological Term Annotations 1.0 null HSD17B4 Pathway Commons Protein-Protein Interactions 1.0 null AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21953 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Glucose dbGAP Gene-Trait Associations 1.0 0.094059 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937293 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -2.07549 orbital frontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872139 growth abnormality GWASdb SNP-Phenotype Associations 1.0 0.263141 PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null PMC8168563-supp_gad.348295.121_Supplemental_Table_S2.xlsx-GSEA_ASCL1_ChIP_Targets-Unnamed_1_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QCQG-1926-SM-2S1PI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08547 Retrosplenial area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03533 HE-80-BQ08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.537404 GTEX-PSDG-1326-SM-48TD2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30825 H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null periodontal pocket MGI Mouse Phenotype Associations 2023 1.0 null GSE190384,GSE190386_6_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null abnormal seminal vesicle morphology IMPC Knockout Mouse Phenotypes 1.0 null SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null OTUD4 Pathway Commons Protein-Protein Interactions 1.0 null TUBB Pathway Commons Protein-Protein Interactions 1.0 null BB-44-SX65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.786884 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5569 H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dental enamel hypoplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 2.2993 urinary bladder HPA Tissue Protein Expression Profiles 1.0 1.62621 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null autosomal dominant inheritance HPO Gene-Disease Associations 1.0 null GNAS Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S7SF-1426-SM-4AT5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.909813 GSE173307,GSE173391_0_v_1_rgcc_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOD1 ENCODE Transcription Factor Targets 1.0 null Perturb_14495_KO_Tcfl5_SRP322934 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.15426 cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58024 GSE132948,GSE132949_2_v_5_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE149903_5_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSMC6 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_1_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null MZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.83517 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.99484 GTEX-TKQ1-0326-SM-4DXSM GTEx Tissue Sample Gene Expression Profiles 1.0 1.30104 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T3-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior Open Bite DisGeNET Gene-Disease Associations 1.0 null GSE233049_2_v_0_atf3_human RummaGEO Gene Perturbation Signatures -1.0 null IM-95 COSMIC Cell Line Gene Mutation Profiles 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.954668 GTEX-T5JC-0226-SM-32PMA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35094 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null PMC6122955-elife-33947-supp2.xlsx-NY8_v_NY15_DE_Bru-seq-HNF1A-regulated_genes_Bru-seq_after_shRNA_in_NY8_or_NY15_cells_-_related_to_Figure_7A_HNF1A Rummagene Transcription Factor Associations 2026 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054131 HES2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0125 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE135352_2_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null Craniofacial Abnormalities CTD Gene-Disease Associations 1.0 2.88009 hsa-miR-3135b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16036 RBM14 Pathway Commons Protein-Protein Interactions 1.0 null BB-77-QQ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.645324 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.473 SUZ12 ChEA Transcription Factor Targets 1.0 null mcf7 HPA Cell Line Gene Expression Profiles 1.0 0.879429 GTEX-XPVG-2626-SM-4B669 GTEx Tissue Sample Gene Expression Profiles 1.0 0.843236 MCF7_WHI-P154_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147986 NR2C2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13075_KO_Atm_SRP062722 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BD-18-MM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.411397 MCF7_WHI-P154_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136524 MCF7_MK-0752_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0126314 SFPQ Pathway Commons Protein-Protein Interactions 1.0 null AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE201217_4_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GCIY CCLE Cell Line Gene CNV Profiles -1.0 -1.32754 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-WL-A834-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QB-88-PG52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257405 Field CA2, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09036 G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02201 superficial stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10388 GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null RH30 CCLE Cell Line Gene Expression Profiles -1.0 -2.13709 GAPVD1 Pathway Commons Protein-Protein Interactions 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-1626-SM-2HMJF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969287 GSE158834_11_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null DE-34-DT75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.525659 GSE252857_2_v_3_prednisone_mouse RummaGEO Drug Perturbation Signatures 1.0 null AD-99-SN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228241 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4SY-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.520136 scaly skin MGI Mouse Phenotype Associations 2023 1.0 null SP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 108.184 BBS9 Pathway Commons Protein-Protein Interactions 1.0 null SK-N-DZ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.953689 dorsolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01789 GTEX-XV7Q-0626-SM-4BRV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01308 PABPC1 Pathway Commons Protein-Protein Interactions 1.0 null GNB2 Pathway Commons Protein-Protein Interactions 1.0 null MET Pathway Commons Protein-Protein Interactions 1.0 null Secondary enamel knot TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.171 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null germ layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.159594 RXR-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE217115_2_v_4_alectinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-1326-SM-48TCG GTEx Tissue Sample Gene Expression Profiles 1.0 1.47819 GSE131649_2_v_3_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null RPL14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.722 SIN3B ChEA Transcription Factor Targets 1.0 null SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37986 PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.298 GSE101112_0_v_4_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null MDAMB436 CCLE Cell Line Gene CNV Profiles 1.0 1.84701 PRPF19 Pathway Commons Protein-Protein Interactions 1.0 null dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42763 dental malocclusion HPO Gene-Disease Associations 1.0 null CSNK1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14983 HNRNPC Pathway Commons Protein-Protein Interactions 1.0 null Bone sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.238 GSE158834_0_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069609 GSE122067_2_v_0_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Tubastatin A HCl_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135335 Disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 PMC11077374__F1 PFOCR Pathway Figure Associations 2024 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EK-01A-12R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178532_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null 7538_RPS8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.780751 BRI3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59069 RPS24 Pathway Commons Protein-Protein Interactions 1.0 null Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.467 GSE158632_2_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.586137 SLC41A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59283 Lung adenocarcinoma_LUAD_TCGA-78-8660-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157050,GSE157051_2_v_4_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null small testis IMPC Knockout Mouse Phenotypes 1.0 null MCF7_MC1568_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0255151 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE173201_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null U118MG CCLE Cell Line Gene Expression Profiles -1.0 -1.91674 ATP5A1 Pathway Commons Protein-Protein Interactions 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.450712 disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GSE158834_11_v_8_palm_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE222758_0_v_1_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null BE-31-XV38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.77878 TBK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32539 ALL-PO Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.30969 Superior central nucleus raphe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42117 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29297 GSE167956_1_v_0_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tumor Cell Invasion DisGeNET Gene-Phenotype Associations 1.0 null three GeneRIF Biological Term Annotations 1.0 null regulation of cell migration GO Biological Process Annotations 2025 1.0 null SNU1196 DepMap CRISPR Gene Dependency 1.0 6.30222 STIP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE122215,GSE122217_0_v_1_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null PARP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37712 superficial stratum of PCPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.61751 GTEX-QLQ7-1926-SM-2S1R6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93802 OCT4-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16475 GSE128232,GSE128233_1_v_0_phf2_human RummaGEO Gene Perturbation Signatures 1.0 null Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HME1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.619 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320094 GSE116810_5_v_4_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null Epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.5737 TCF3_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.991055 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.782901 GSE158834_10_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A875-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Incisor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.387 KLHDC3 Pathway Commons Protein-Protein Interactions 1.0 null autosomaldominant GeneRIF Biological Term Annotations 1.0 null RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201217_2_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null IARS Pathway Commons Protein-Protein Interactions 1.0 null YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11814 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ANAPC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03716 mantle zone of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30335 CRY1 Pathway Commons Protein-Protein Interactions 1.0 null PABPC4 Pathway Commons Protein-Protein Interactions 1.0 null MZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50797 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE206516,GSE206518_6_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null TP53BP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE193258,GSE193259_9_v_0_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE77108_0_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WDR5 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_FLLL32_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142119 prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.108287 GSE174498,GSE174500_3_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.847431 GTEX-XMD3-2326-SM-4AT5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56223 PRDX1 Pathway Commons Protein-Protein Interactions 1.0 null GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GD-82-CS38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.526544 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.596 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 mantle zone of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4676 scale TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.391931 posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07455 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Marfanoid habitus and intellectual disability ClinVar Gene-Phenotype Associations 2025 1.0 null CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.65265 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null filament GeneRIF Biological Term Annotations 1.0 null PDHB Pathway Commons Protein-Protein Interactions 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15873 hsa-miR-4673 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.290565 Dental lamina TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.557 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HIST1H4F Pathway Commons Protein-Protein Interactions 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GCM2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.5653 NINJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33796 GTEX-S3XE-1726-SM-3K2AM GTEx Tissue Sample Gene Expression Profiles 1.0 1.13109 TE-32-AC63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.306456 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8666_TAF5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.910507 sporangiophore TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.117351 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE216043_10_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221727 PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KPNRTBM1 CCLE Cell Line Gene Expression Profiles -1.0 -2.04114 AXIN1 Pathway Commons Protein-Protein Interactions 1.0 null Buccal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.988 adult medulloblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.38865 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8634-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KP1N DepMap CRISPR Gene Dependency 1.0 2.41532 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4869-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retrosplenial area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33961 CALD1 Pathway Commons Protein-Protein Interactions 1.0 null GSE128333_3_v_5_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE228106_3_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01875 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18537 GSE157555,GSE157556_3_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Bisindolylmaleimide IX_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139349 FER Pathway Commons Protein-Protein Interactions 1.0 null Cervical Cancer DisGeNET Gene-Disease Associations 1.0 null SNRNP200 Pathway Commons Protein-Protein Interactions 1.0 null GSE213228_1_v_5_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE160083,GSE160084_2_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XXEK-0326-SM-4BRVV GTEx Tissue Sample Gene Expression Profiles 1.0 1.50783 NB4 CCLE Cell Line Gene CNV Profiles -1.0 -2.06649 SPTBN1 Pathway Commons Protein-Protein Interactions 1.0 null GSE111102,GSE111105_1_v_5_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null CB-55-AK76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233699 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SURF4 Pathway Commons Protein-Protein Interactions 1.0 null pollen mother cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.182895 GSE132369,GSE132371_5_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null NR2C2 ENCODE Transcription Factor Targets 1.0 null NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.56479 BC-54-ON71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.415214 BF-10-IO69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.600182 XRCC5 Pathway Commons Protein-Protein Interactions 1.0 null GSE93124_0_v_1_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PTBP1 Pathway Commons Protein-Protein Interactions 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHWD-1826-SM-3LK6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.28036 GSE139016_0_v_2_disulfiram_human RummaGEO Drug Perturbation Signatures -1.0 null GSE180200,GSE180201_3_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26701 DELE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05783 PCI-30 COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Pirarubicin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200515 HuO-3N1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.27756 DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.542784 Perturb_17944_KO_Abcc5_SRP058071 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.75451 dorsolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.942322 GSE166004_5_v_4_pld1_mouse RummaGEO Gene Perturbation Signatures -1.0 null REH COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE199543,GSE239447_0_v_4_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null FA-36-VA24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.416836 ovary GTEx Tissue Gene Expression Profiles -1.0 -0.841929 EXOSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15305 HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null SEC13 Pathway Commons Protein-Protein Interactions 1.0 null HSP90AA1 Pathway Commons Protein-Protein Interactions 1.0 null GSE211425_1_v_0_mettl3_human RummaGEO Gene Perturbation Signatures -1.0 null Cementum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.241 PMC11821528-41588_2024_2050_MOESM12_ESM.xlsx-MR-Unnamed_2_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null NB5 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.34433 FNDC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00896 cell culture TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.285316 Cervical squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48388 enamel epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.579216 GSE197564,GSE198513_2_v_0_mettl3_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPN2 Pathway Commons Protein-Protein Interactions 1.0 null RBBP7 Pathway Commons Protein-Protein Interactions 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12274 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPP1R3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30735 BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.32282 PFN1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null parahippocampal gyrus, right, bank of the cos Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.875662 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE221020,GSE221023_2_v_1_pten_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RU72-1226-SM-2TF6N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2174 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.98317 HS 683 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00522 496100538_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.84085 MCF7_Filgotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01777 PSMD12 Pathway Commons Protein-Protein Interactions 1.0 null H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null allele GeneRIF Biological Term Annotations 1.0 null NFI-21473784-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.02313 GTEX-QEG5-1426-SM-447AS GTEx Tissue Sample Gene Expression Profiles 1.0 1.30885 Perturb_6878_KD_LINC00857_SRP371132 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.3008 GTEX-PLZ4-1626-SM-3P618 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25085 GSE113106_2_v_4_dnm2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_2_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null ameloblastic layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.980217 BCL3 ENCODE Transcription Factor Targets 1.0 null Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.5967 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4818 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.01345 HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17156 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.064363 GTEX-XYKS-2126-SM-4E3IB GTEx Tissue Sample Gene Expression Profiles 1.0 1.11291 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45X-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures -1.0 null MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24917 GSE143830_0_v_1_trex1_mouse RummaGEO Gene Perturbation Signatures -1.0 null positive regulation of cell migration GO Biological Process Annotations 2025 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.423567 AURA Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE135352_2_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320009 MCF7_Capecitabine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160425 HNRNPA1L2 Pathway Commons Protein-Protein Interactions 1.0 null tongueepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 Perturb_6869_OE_STBD1_SRP316253 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.20886 OE-78-XD40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.804436 MCF7_Luminespib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140263 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amelogenesis imperfecta DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.968 Nuclear envelope lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.756 Sarcoma_SARC_TCGA-FX-A3NK-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary failure of tooth eruption DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.133 TCF12 ENCODE Transcription Factor Targets 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null GSE60217_1_v_2_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Rucaparib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127179 Placenta TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CDC23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49032 20220088-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Cervix disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.44 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU1J-0326-SM-46MUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.17624 GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null SNRNP40 Pathway Commons Protein-Protein Interactions 1.0 null MZ in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.052 MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-90-7769-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_6_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-XBED-1026-SM-48TCB GTEx Tissue Sample Gene Expression Profiles 1.0 1.48857 invertebrate mandible TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.840769 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 16651409-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null GSE190186,GSE190188_8_v_10_apoe_mouse RummaGEO Gene Perturbation Signatures 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ8-1826-SM-2YUNC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28585 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23603 imperfectacausing GeneRIF Biological Term Annotations 1.0 null HDQP1 CCLE Cell Line Gene CNV Profiles 1.0 1.52259 SENP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18902 GAPDH Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null postnatal lethality, incomplete penetrance MGI Mouse Phenotype Associations 2023 1.0 null GSE128844_0_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Jaw TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.575 GSE122067_2_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33452 GSE207978_1_v_0_rai1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-6761-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF20 Pathway Commons Protein-Protein Interactions 1.0 null diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STAT3-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lung non-small cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.239 Gingival hypertrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.047 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.06081 DYNC1LI1 Pathway Commons Protein-Protein Interactions 1.0 null BL3241 (DHX29) NURSA Protein Complexes 1.0 null K562_SL-327_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152873 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.863665 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8786_Mut_HNF6_SRP217514 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.28295 PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.835762 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.888934 ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.614 Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KR-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XOTO-2126-SM-4B64U GTEx Tissue Sample Gene Expression Profiles 1.0 1.44679 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.979454 RAF1 Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE240027,GSE240030_5_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K36me3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-2526-SM-48TDS GTEx Tissue Sample Gene Expression Profiles 1.0 0.984079 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null AC-92-HS43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.293091 HUVEC Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.75571 HNRNPDL Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles 1.0 1.20373 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.986546 AB-21-VE32_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23689 KLF15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 121.842 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPL4 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_PCI-34051_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144882 HIST1H1A Pathway Commons Protein-Protein Interactions 1.0 null r8 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29657 K562_Alisertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166137 MCF7_Clevudine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157052 GSE127916_1_v_4_nras_human RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.88936 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36717 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09445 placenta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GSE122067_3_v_0_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_7_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null HSP90AA1 Hub Proteins Protein-Protein Interactions 1.0 null hsa-miR-1827 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03506 GSE192663_1_v_5_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null Periodontal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.357 Pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.343 CTCF-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null MZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17116 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE186633_1_v_0_chd1_human RummaGEO Gene Perturbation Signatures -1.0 null HCT-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null TGIF2LX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6447 GSE144838_2_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178907_5_v_3_fkrp_human RummaGEO Gene Perturbation Signatures 1.0 null MCF7_TAK-901_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132497 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79577 metaphase_anaphase_telophase_60min_noscapine_release vs ctrl_HeLa (Human) [19691289] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null abnormal mammary gland morphology IMPC Knockout Mouse Phenotypes 1.0 null MCF7_Sodium Phenylbutyrate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145171 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QD-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_1_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE148200_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null MZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.28034 BL2296 (EDC4) NURSA Protein Complexes 1.0 null GSE158834_0_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null MAF-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.81076 H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RPS13 Pathway Commons Protein-Protein Interactions 1.0 null GSE103068_5_v_7_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE129370_2_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNRNP48 Pathway Commons Protein-Protein Interactions 1.0 null CCT3 Pathway Commons Protein-Protein Interactions 1.0 null CCDC117 Pathway Commons Protein-Protein Interactions 1.0 null RPS11 Pathway Commons Protein-Protein Interactions 1.0 null HCC1937 CCLE Cell Line Gene CNV Profiles 1.0 2.04486 superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29906 GTEX-W5WG-2226-SM-4LMI3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30766 RPS12 Pathway Commons Protein-Protein Interactions 1.0 null TBX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.823 Hypb_Deficiency_GDS3641_522_mouse_Yolk sac from E9 embryos GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eye and adnexa disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.068839 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.613965 salivary gland HPA Tissue Protein Expression Profiles -1.0 -1.00299 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null MCF7_INO-1001_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142332 KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.789 MZ in posterodorsal (superior) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3315 ZE-45-CG69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.612562 GSE169356_2_v_5_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WHSB-1326-SM-3LK6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.19702 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PKNOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8446 AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.488948 r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.59039 CALU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.34174 BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.733431 Malignant Tumor Of Cervix DisGeNET Gene-Disease Associations 1.0 null dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27215 PHOX2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04098 CLTC Pathway Commons Protein-Protein Interactions 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.336 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996862 YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.46903 GSE147876,GSE147877_4_v_7_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE129811_5_v_0_niacin_human RummaGEO Drug Perturbation Signatures 1.0 null 496100641_PCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27134 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10762 GSE125014_6_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG7-1126-SM-4LMK3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29102 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null localization GeneRIF Biological Term Annotations 1.0 null GSE165636_0_v_4_tofacitinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tooth disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.946634 GTEX-O5YW-0126-SM-3LK6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.87126 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.1218 QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.96129 TBC1D17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44925 GSE131649_4_v_11_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE185944_2_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-93-8067-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW1116 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-3591-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null open bite HPO Gene-Disease Associations 1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null r10 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16648 JRK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20422 MCF7_SRT3025 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017463 GTEX-OIZI-1426-SM-3NB1T GTEx Tissue Sample Gene Expression Profiles 1.0 1.35371 GTEX-S341-1726-SM-3K2AK GTEx Tissue Sample Gene Expression Profiles 1.0 1.30787 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75152 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKAA2 Pathway Commons Protein-Protein Interactions 1.0 null CLASP2 Pathway Commons Protein-Protein Interactions 1.0 null JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.778508 inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.858789 GTEX-S4P3-1126-SM-4AD52 GTEx Tissue Sample Gene Expression Profiles 1.0 0.868091 GTEX-W5WG-2726-SM-4LMIC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908132 IF-31-RN78_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.51472 internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0126-SM-2XCBB GTEx Tissue Sample Gene Expression Profiles 1.0 0.91102 ZMAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04199 p3 portion of paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04925 GTEX-QEL4-1526-SM-447AB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19909 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE254770_3_v_1_sin3b_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41478 PRPF8 Pathway Commons Protein-Protein Interactions 1.0 null GOLGB1 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7873-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE129389_0_v_5_tropifexor_mouse RummaGEO Drug Perturbation Signatures 1.0 null RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09205 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08265 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.886288 GSE135030_8_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.499615 GTF2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22068 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.679658 GCT COSMIC Cell Line Gene Mutation Profiles 1.0 null Developmental and epileptic encephalopathy 93 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.142 GAK Pathway Commons Protein-Protein Interactions 1.0 null BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.679956 intermediate stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35152 PPDPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58848 Head and neck cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.276 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null esophagus GTEx Tissue Gene Expression Profiles 1.0 0.990187 DYRK1A Kinase Library Serine Threonine Kinome Atlas 1.0 null abnormal kidney morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-XBEW-1326-SM-4AT63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30257 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAB1 Pathway Commons Protein-Protein Interactions 1.0 null dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.24134 GSE137653_4_v_0_siglecf_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE239844_6_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null CALU6_LUNG CCLE Cell Line Proteomics 1.0 2.1348 PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-639-ENSG00000181135_ZNF707 Rummagene Transcription Factor Associations 2026 1.0 null PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG Rummagene Transcription Factor Associations 2026 1.0 null reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046335 Amelogenesis imperfecta hypomaturation type 2A2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.469 GTEX-XQ8I-1526-SM-4BOOH GTEx Tissue Sample Gene Expression Profiles 1.0 1.21828 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.6665 496100470_HIP_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.49041 probands GeneRIF Biological Term Annotations 1.0 null CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RB1CC1 Pathway Commons Protein-Protein Interactions 1.0 null SACS Pathway Commons Protein-Protein Interactions 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.742 GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55E-1326-SM-48FCR GTEx Tissue Sample Gene Expression Profiles 1.0 1.49437 BV-173 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 PPP1R9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24939 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64995 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K36me3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64024 mandible TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.267791 GSE146074_1_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPS6KA6 Pathway Commons Protein-Protein Interactions 1.0 null GSE254770_0_v_1_sin3b_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUP-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OHPM-0726-SM-3LK7A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858934 MCF7_Cediranib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145769 H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100631_PCx_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19251 NCI-H358 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24786 BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.329566 PMC7642293-41467_2020_19328_MOESM11_ESM.xlsx-20191030_AA_iTop3Summary-GN_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36835 H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null D-542MG Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.37067 superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06535 GSE233049_1_v_3_atf3_human RummaGEO Gene Perturbation Signatures -1.0 null BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.917256 MCF7_PD173074_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137519 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.55943 SUZ12-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE148200_1_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Tooth agenesis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.374 RPAP3 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_15410_KD_GATA2_SRP043960 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -14.1972 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_7188_OE_TMEM119_SRP279053 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.9626 GTEX-WRHK-1726-SM-3MJFK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40955 MCF7_Thalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0268586 RPS9 Pathway Commons Protein-Protein Interactions 1.0 null prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 104.766 whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063523 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE225684_0_v_2_tfap4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_6796_KD_BRD4_SRP063978 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE158834_1_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.420458 K562_Capecitabine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204415 FOXP2 ENCODE Transcription Factor Targets 1.0 null DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE213588_8_v_3_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-8166-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151119_3_v_1_hsf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FGF22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18467 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30658 GTEX-RTLS-0426-SM-2TF5K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60147 heart TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058845 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.832645 GSE146982_4_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE109140_0_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null ovary_6a HPA Tissue Sample Gene Expression Profiles -1.0 -0.968409 keratin filament GO Cellular Component Annotations 2023 1.0 null GSE96641_5_v_0_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE163862_2_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZNF16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88982 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13128 DD-74-PJ26_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225334 Inner dental epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.743 CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-1226-SM-4DXTM GTEx Tissue Sample Gene Expression Profiles 1.0 1.15774 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20522 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148200_0_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GA-28-SS67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.241725 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SQSTM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE157555,GSE157556_5_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null IC-05-AW29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.371586 LAGE3 Pathway Commons Protein-Protein Interactions 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Palmoplantar keratosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.26 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0426-SM-3NM9H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949532 SC-72-YW56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.226539 CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOMEZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07763 fewer GeneRIF Biological Term Annotations 1.0 null GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31167 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM110C Pathway Commons Protein-Protein Interactions 1.0 null CAMK2D Pathway Commons Protein-Protein Interactions 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239578_5_v_4_cxadr_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZIC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 84.4956 pilus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.659482 TCEB2 Pathway Commons Protein-Protein Interactions 1.0 null anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.17899 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.45372 DSP Pathway Commons Protein-Protein Interactions 1.0 null PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_CAMTA1_vs_subEV-Gene_CAMTA1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_11_v_3_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RTN4RL2 Pathway Commons Protein-Protein Interactions 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.70273 GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1 Rummagene Transcription Factor Associations 2026 1.0 null GSE255432_6_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE86507,GSE86509_0_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38192 GTEX-TMZS-0126-SM-3DB9Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.894402 GSE102675_3_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4844-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Amelogenesis imperfecta type 3C DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.504 MZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40343 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041444 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47X-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null LXR-22292898-THP-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Head and neck squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.047 GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.38732 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE193258,GSE193259_5_v_1_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-TSE9-0226-SM-3DB84 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05223 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47979 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33225 TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3817 CEBPB ENCODE Transcription Factor Targets 1.0 null WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.54618 MCF7_Raltitrexed_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204459 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MRPS26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20918 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U412-0426-SM-3DB9O GTEx Tissue Sample Gene Expression Profiles 1.0 0.905041 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Lenalidomide_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165489 Nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42548 eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRP-2426-SM-2S1NR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 outer CP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05359 GTEX-P4QT-2426-SM-3NMCL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27205 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.9226 GTEX-U8T8-0126-SM-3DB94 GTEx Tissue Sample Gene Expression Profiles 1.0 0.950305 protein localization to cytoskeleton GO Biological Process Annotations 2023 1.0 null GSE88819_11_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE245270_1_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null UMUC1 CCLE Cell Line Gene Expression Profiles 1.0 1.44711 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SEC23B Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_1_v_3_palm_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EPB41L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24054 VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.41969 CE-15-YU05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250644 SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null MCF7_SNS-314 Mesylate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125898 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q8-01A-31R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF211 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1334 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.368835 IDS Pathway Commons Protein-Protein Interactions 1.0 null FB-29-KC76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215836 Perturb_12556_KO_Sirt6_SRP302465 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.37161 DSC1 Pathway Commons Protein-Protein Interactions 1.0 null CTCFL_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE166315_1_v_4_docetaxel_mouse RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LD-39-FL02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.22452 inner SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27469 GOLGA2 Pathway Commons Protein-Protein Interactions 1.0 null K562_TGX-221_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173305 GSE74383_2_v_0_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53582 GEMIN5 Pathway Commons Protein-Protein Interactions 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06376 GTEX-X4XX-0626-SM-3NMC1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20988 U251MG CCLE Cell Line Gene CNV Profiles -1.0 -1.81451 Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.553 nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.067735 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.94593 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null 17683608-TableS1 GeneSigDB Published Gene Signatures 1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123861_1_v_0_sin3a_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158197_6_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null CFPAC1 DepMap CRISPR Gene Dependency 1.0 2.2874 Organism form TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GW-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2028_KO_Dnmt3a_SRP045223 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.84735 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01647 cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.386979 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR31 DepMap CRISPR Gene Dependency 1.0 2.82774 periventricular stratum of p1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04343 GSE111247_14_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null Teeth hard tissue disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 DST Pathway Commons Protein-Protein Interactions 1.0 null PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.057678 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null GSE211151_1_v_4_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.887383 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18719 KRT18 Pathway Commons Protein-Protein Interactions 1.0 null Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 GNAI2 Pathway Commons Protein-Protein Interactions 1.0 null EIF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19318 MCF7_PD98059_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016196 RAD21 ENCODE Transcription Factor Targets 1.0 null SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52093 PRRC2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3255 GSE125219,GSE125221_3_v_0_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null LD-39-FL02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.324879 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93892 GSE256181_1_v_0_etv2_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_6867_OE_CRLM1_SRP309080 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE86507,GSE86509_3_v_2_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null APBA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10127 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01671 abnormal glucose homeostasis GWASdb SNP-Phenotype Associations 1.0 0.21543 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70208 GSE233183,GSE233187_2_v_9_larp1_human RummaGEO Gene Perturbation Signatures 1.0 null Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 TGIF2LY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0281 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.846874 VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18024 GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33809 GSE180185_9_v_5_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE217115_2_v_0_alectinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null RPS20 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pericardium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.806465 MCF7_Lomustine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167153 NE-20-WM78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261644 GTEX-U4B1-0826-SM-4DXTW GTEx Tissue Sample Gene Expression Profiles 1.0 1.50685 TNIK Pathway Commons Protein-Protein Interactions 1.0 null YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.89895 GSE200673,GSE200691_2_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_11_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13398 GTEX-OHPL-0126-SM-2HMJ7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.989448 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNRNPH1 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null STOX2 Pathway Commons Protein-Protein Interactions 1.0 null FYTTD1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-4741 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null abnormality of the oral cavity HPO Gene-Disease Associations 1.0 null PMC8500868-401_2021_2354_MOESM5_ESM.xlsx-GEP_PATZ1-Gene_Symbol_PATZ1 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DLST Pathway Commons Protein-Protein Interactions 1.0 null MYO3B Kinase Library Serine Threonine Kinome Atlas 1.0 null Hypoglossal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39568 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_MK-5108_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0130752 DIAPH3 Pathway Commons Protein-Protein Interactions 1.0 null obesity GWASdb SNP-Phenotype Associations 1.0 0.6209 HEC50B_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.04017 GSE183113_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.26634 HCC1937 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.76506 Trichodontoosseous syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.198 MFSD14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38068 LARP1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null Mustard Gas CTD Gene-Chemical Interactions 1.0 null PAX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3726 EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE122711_1_v_0_mpc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RPLP0 Pathway Commons Protein-Protein Interactions 1.0 null Anterior cingulate area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1517 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.046733 orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22158 CH25H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06302 Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184399_0_v_2_cnot1_human RummaGEO Gene Perturbation Signatures 1.0 null Cochlear nucleus, subpedunclular granular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23854 CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein kinase binding GO Molecular Function Annotations 2025 1.0 null NSUN2 Pathway Commons Protein-Protein Interactions 1.0 null GSE206516,GSE206518_2_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_13400_KD_PBX1_SRP302267 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.809 EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.978501 anterior open bite HPO Gene-Disease Associations 1.0 null GSE190384,GSE190386_2_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912212 ZNF514 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34751 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67558 CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.391553 GSE92434_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null imperfect GeneRIF Biological Term Annotations 1.0 null GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836526 all HPO Gene-Disease Associations 1.0 null SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPALPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28686 GSE221633_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures 1.0 null amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.889433 CDK11A Pathway Commons Protein-Protein Interactions 1.0 null GSE199204,GSE211619_4_v_3_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PCMTD2 Pathway Commons Protein-Protein Interactions 1.0 null OCUB-M COSMIC Cell Line Gene Mutation Profiles 1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18934 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22446 MCF7_IOX2_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190545 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TSPYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0256 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356533 increased circulating potassium level MGI Mouse Phenotype Associations 2023 1.0 null positive regulation of cell motility GO Biological Process Annotations 2023 1.0 null GSE158834_2_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null KRT14 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-3922-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE125014_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null KRT77 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P4QS-1826-SM-2S1NI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 GSE202434,GSE202438_4_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null dental pulp TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.226155 GSE158715_3_v_0_cyp1b1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE89018_12_v_14_cry2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_1_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null TE8 CCLE Cell Line Gene CNV Profiles 1.0 1.45569 Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cuneiform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.924741 MAC2A DepMap CRISPR Gene Dependency 1.0 3.01867 OPM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.84099 Acute pancreatitis_Pancreas_GSE3644 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.32733 Perturb_11857_KO_miR301a_SRP131007 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.07331 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44725 KP3 DepMap CRISPR Gene Dependency 1.0 2.5188 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03204 GSE121809_1_v_0_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS18 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08223 Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.428 RS4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null EPPK1 Pathway Commons Protein-Protein Interactions 1.0 null GSE205730,GSE205731_2_v_0_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5977-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55E-1126-SM-48FDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851026 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7056-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GSE142210_4_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE94849_3_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DLD-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.122 GARIN1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07281 CAMKK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K91ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null demonstrate GeneRIF Biological Term Annotations 1.0 null GSE60217_1_v_7_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2974 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 99.102 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158182_3_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE184892_7_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null Cervix carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.942885 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.5254 GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19238 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3268 496100632_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13305 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NALM-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.878166 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.325 increased body weight GWASdb SNP-Phenotype Associations 1.0 0.6209 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.01577 TC-59-QN21_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.428036 ovary_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.18373 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47742 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.21655 MCF7_GSK1070916_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0123442 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.939748 bounding membrane of organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047079 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anatomical structure development GO Biological Process Annotations 2015 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN Rummagene Transcription Factor Associations 2026 1.0 null RPL13A Pathway Commons Protein-Protein Interactions 1.0 null LD-69-ZV56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.12123 A549_UNC0631_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127632 GSE214823,GSE214824_3_v_1_crtc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE225656_2_v_3_tsc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null DHX15 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDVN-2326-SM-2S1PF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.88591 generalized GeneRIF Biological Term Annotations 1.0 null GTEX-RUSQ-0826-SM-47JWW GTEx Tissue Sample Gene Expression Profiles 1.0 1.103 ANTXR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21695 Ebf4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.0606 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PECAPJ49 CCLE Cell Line Gene Expression Profiles 1.0 1.62981 Lung squamous cell carcinoma_LUSC_TCGA-77-7463-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16386 CCK-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null PANC-08-13 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cisplatin_homo sapiens_gpl6480_gse33482 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null digits BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.10936 Kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 JJN-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE172016_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null r8 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.03166 STK33 Pathway Commons Protein-Protein Interactions 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.956528 THOC2 Pathway Commons Protein-Protein Interactions 1.0 null flower TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061967 GTEX-XUYS-0126-SM-47JWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04569 Gastric adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 SOX2 ChEA Transcription Factor Targets 1.0 null H3K4me1_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCIH2126 DepMap CRISPR Gene Dependency 1.0 3.03216 GSE222758_0_v_3_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null r9 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.47823 VPS13B Pathway Commons Protein-Protein Interactions 1.0 null KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.414536 TP63 ChEA Transcription Factor Targets 1.0 null LS 180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.988905 GSE248045,GSE248046_0_v_5_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE128333_4_v_0_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_7238_KO_CDK19_SRP271652 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.0824 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169205_0_v_6_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 89.6445 KLF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 124.866 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null resulted GeneRIF Biological Term Annotations 1.0 null DHX9 Pathway Commons Protein-Protein Interactions 1.0 null Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.337 Odontoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.801 CHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.941266 GSE146982_4_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null SNU-407 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE221327_10_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null GSE206516,GSE206518_0_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.31056 PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null COLO-668 COSMIC Cell Line Gene Mutation Profiles 1.0 null HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9148 GSE158834_10_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null A549_SRT1720 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136695 GTEX-P4PP-1826-SM-2S1NT GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 GSE124375_10_v_9_chd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.824348 type iii protein secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.08831 Brain - Caudate (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 1.0 1.40555 DSG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46098 AD-66-NV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.952824 Enamel knot TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.195 Renal Carcinoma DisGeNET Gene-Disease Associations 1.0 null Perturb_15717_OE_Ctcf_SRP173291 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.0512 PMC4219345-1471-2121-14-52-S4.xlsx-BORIS_6dN-Gene_Symbol_CTCFL Rummagene Transcription Factor Associations 2026 1.0 null amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13578 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2008 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MSH6 Pathway Commons Protein-Protein Interactions 1.0 null GSE174701_5_v_6_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_UNC1999_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125019 HSPA1B Pathway Commons Protein-Protein Interactions 1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.987523 GSE166315_2_v_0_docetaxel_mouse RummaGEO Drug Perturbation Signatures 1.0 null LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6516-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA ChEA Transcription Factor Targets 2022 1.0 null GSE135352_6_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Ameloblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.79 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WK11-2726-SM-3NMAQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.848822 periventricular stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96571 abnormal mammary gland morphology MGI Mouse Phenotype Associations 2023 1.0 null PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA Rummagene Transcription Factor Associations 2026 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_3_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19059 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02537 PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.119 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.6856 FRG1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061534 SELENOV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.062 FGD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32226 tripartite atp-independent periplasmic transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.78913 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A845-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.190271 IQGAP3 Pathway Commons Protein-Protein Interactions 1.0 null GSE231524,GSE231526_0_v_1_dusp6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE135030_11_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Musculoskeletal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.005 GTEX-P4QT-0626-SM-3NMCP GTEx Tissue Sample Gene Expression Profiles 1.0 1.19629 T3M4 CCLE Cell Line Gene Expression Profiles 1.0 1.78797 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.20207 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AD-18-XC14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21965 Orbital area, medial part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28602 2313287 CCLE Cell Line Gene CNV Profiles 1.0 1.4411 QARS Pathway Commons Protein-Protein Interactions 1.0 null PKN1 Pathway Commons Protein-Protein Interactions 1.0 null intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 microsporangium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.192076 EFTUD2 Pathway Commons Protein-Protein Interactions 1.0 null RARS Pathway Commons Protein-Protein Interactions 1.0 null molaris TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.681064 GSE103068_5_v_1_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null ITGB4 Pathway Commons Protein-Protein Interactions 1.0 null Bed nuclei of the stria terminalis, anterior division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16301 GSE164757,GSE164759_4_v_0_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null MCF7_ZM 447439_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0207196 GSE57871_11_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842945 abnormal seminal vesicle morphology MGI Mouse Phenotype Associations 2023 1.0 null NUDCD3 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Fluorouracil_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0192049 Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW1573_LUNG CCLE Cell Line Proteomics 1.0 4.44176 GSE142210_4_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null RPS3A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HNT-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.836892 Lung adenocarcinoma_LUAD_TCGA-86-8672-01A-21R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE181003_3_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RBE DepMap CRISPR Gene Dependency 1.0 2.10101 Perturb_11394_KD_USP7_SRP292689 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-OHPM-0126-SM-2YUN9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.837769 NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Amelogenesis imperfecta DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null COL8A1 Pathway Commons Protein-Protein Interactions 1.0 null PRPF4 Pathway Commons Protein-Protein Interactions 1.0 null Sense organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.141 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.87589 GTEX-OXRK-0526-SM-3NB2F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31409 ZNF768 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3104 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43429 GTEX-T8EM-1026-SM-3DB7M GTEx Tissue Sample Gene Expression Profiles 1.0 0.921051 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.996973 intracellular GeneRIF Biological Term Annotations 1.0 null AA-39-BD24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.557185 PISD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86754 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39778 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14174 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Costunolide_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180733 GSE206516,GSE206518_1_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal cholesterol homeostasis IMPC Knockout Mouse Phenotypes 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null GSE216538_0_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null GSE198380_0_v_1_phgdh_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2569 10663_ZNF830_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.61738 HNF4A ENCODE Transcription Factor Targets 1.0 null PMC12486367-Supplementary_Data2.pdf-488-ZNF445_ZNF445 Rummagene Transcription Factor Associations 2026 1.0 null TMTC2 Pathway Commons Protein-Protein Interactions 1.0 null SNRPD2 Pathway Commons Protein-Protein Interactions 1.0 null PMC2665242-gkp077_nar-02582-s-2008-File009.xls-Supple_Table3_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42763 GTEX-TKQ2-1026-SM-33HB7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4355 GSE217115_2_v_5_alectinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WRL-68 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.836 primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.97785 GTEX-PWN1-0626-SM-48TDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.46202 APC Pathway Commons Protein-Protein Interactions 1.0 null digestive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 WNK3 Kinase Library Serine Threonine Kinome Atlas 1.0 null PMC6802116-41467_2019_12517_MOESM5_ESM.xlsx-Sheet1-D9_8_GNF2-SERPINB5_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WEY5-0926-SM-4LMI4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.827364 GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures 1.0 null VRK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE139239_3_v_6_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TTC9C Pathway Commons Protein-Protein Interactions 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MGAT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2076 GABPA ENCODE Transcription Factor Targets 1.0 null GTEX-Q2AG-0926-SM-48U1Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34882 MCF7_AC480_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199358 EIF2B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17282 intermediate stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69176 NCIH650 CCLE Cell Line Gene CNV Profiles -1.0 -1.50602 ES3 COSMIC Cell Line Gene Mutation Profiles 1.0 null ACTN4 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRP-0926-SM-48TC1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32941 embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE132759_4_v_2_fgfr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC12486367-Supplementary_Data2.pdf-297-ZNF749_ZNF749 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Lomustine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140686 GSE223334_3_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04548 amelogenesis imperfecta DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 2.35976 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.409 EZH2-23942234-MYOBLASTS AND MYOTUBES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Orbital area, ventrolateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68069 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.293779 YE-46-YA12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.370248 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Wnt signalosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.702 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04214 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-124-3p MiRTarBase microRNA Targets 1.0 null GSE240258_0_v_1_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PKR Kinase Library Serine Threonine Kinome Atlas 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12712 Stratum intermedium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.971 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null GSE162892_4_v_5_isox_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Malocclusion DisGeNET Gene-Disease Associations 1.0 null estradiol_homo sapiens_gpl14550_gse35034 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC ChEA Transcription Factor Targets 2022 1.0 null H3K36me3_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dental enamel hypoplasia DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 CDC42EP1 Pathway Commons Protein-Protein Interactions 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial part of r8B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38402 ANXA2 Pathway Commons Protein-Protein Interactions 1.0 null GSE192663_3_v_5_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null PSMD1 Pathway Commons Protein-Protein Interactions 1.0 null VMRCLCD DepMap CRISPR Gene Dependency 1.0 3.9749 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.857153 PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoprot_AKT1_AKT2_KD_vs_SCR-Unnamed_3_AR Rummagene Transcription Factor Associations 2026 1.0 null Wart TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.851 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Urinary bladder cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.201 A549_CYC116_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154675 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.902379 Ovarian disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 PMC8168563-supp_gad.348295.121_Supplemental_Table_S2.xlsx-GSEA_ASCL1_ChIP_Targets-ASCL1_ChIP_Targets_Conserved_in_mose_SCLC_and_human_SCLC_Models_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null SARC9371 COSMIC Cell Line Gene Mutation Profiles 1.0 null AA-23-FM46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.613049 GTEX-WFJO-0826-SM-4LVM5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33756 GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838054 ARHGEF2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865428 FLNB Pathway Commons Protein-Protein Interactions 1.0 null GSE168233_0_v_1_setdb1_human RummaGEO Gene Perturbation Signatures 1.0 null PRMT1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T6MN-1526-SM-4DM5P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93535 TCFL5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.2413 Lung adenocarcinoma_LUAD_TCGA-78-7153-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUZC-0426-SM-4BOPE GTEx Tissue Sample Gene Expression Profiles 1.0 1.35577 Secondary motor area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14051 GTEX-OXRO-1926-SM-2S1O3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63548 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SC-8002 (ESR1) NURSA Protein Complexes 1.0 null SMC4 Pathway Commons Protein-Protein Interactions 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-125b TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 KDM5B ENCODE Transcription Factor Targets 1.0 null RPS6KA4 Pathway Commons Protein-Protein Interactions 1.0 null COR-L303 COSMIC Cell Line Gene Mutation Profiles 1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878892 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ATF4_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null MAP3K11 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1268b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Ovary Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.901 RPL23A Pathway Commons Protein-Protein Interactions 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain - Cerebellar Hemisphere GTEx Tissue Gene Expression Profiles 2023 1.0 2.61579 LASV_FML29_24hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.677868 GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76632 AF-30-GH67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301085 GSE223008_9_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null PCBP1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE172189_0_v_1_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35092 ZNF143 ENCODE Transcription Factor Targets 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1304 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 protein kinase binding GO Molecular Function Annotations 2023 1.0 null Retrosplenial area, lateral agranular part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6613 MCF7_Ellagic acid_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135224 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130956_0_v_1_icaritin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2BK12ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_Cimetidine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0233861 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146982_3_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null phenotype GeneRIF Biological Term Annotations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE167956_4_v_0_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null developmental process GO Biological Process Annotations 2015 1.0 null MCF7_Triamcinolone Acetonide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.00998007 ZNF213 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.2111 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0226-SM-2HMKQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.13234 Penis_Foreskin_Keratinocyte_Primary_Cells_skin03 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.205 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CXXC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76106 GSE208254_4_v_2_irf8_mouse RummaGEO Gene Perturbation Signatures 1.0 null MTA2 Pathway Commons Protein-Protein Interactions 1.0 null MS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null MLS syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.198 RPS19 Pathway Commons Protein-Protein Interactions 1.0 null PPP4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10971 SNX22 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amelogenesis imperfecta hypomaturation type 2A5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.558 Merocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.565 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10718 MCF7_Tranylcypromine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0133542 Perturb_430_KD_FOXM1_SRP371675 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.38537 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34009 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878126 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G28T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20673 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5677-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AZI2 Pathway Commons Protein-Protein Interactions 1.0 null ZEB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3135b TargetScan Predicted Conserved microRNA Targets 1.0 0.031759 SAS DepMap CRISPR Gene Dependency 1.0 2.21652 CA-68-KG29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.756328 A549_Hesperadin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0123187 FOXA1_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4568 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29309 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4G_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YV-1626-SM-2YUNJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00444 LD-69-ZV56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.6606 PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOLR1 Pathway Commons Protein-Protein Interactions 1.0 null RPS26 Pathway Commons Protein-Protein Interactions 1.0 null GSE205163,GSE205164_3_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC Rummagene Transcription Factor Associations 2026 1.0 null NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100515_HIP_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.08498 Prostate adenocarcinoma_PRAD_TCGA-HI-7171-01A-12R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNRNPA2B1 Pathway Commons Protein-Protein Interactions 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NB-12-ZK38_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240845 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null colonrectum_a HPA Tissue Sample Gene Expression Profiles 1.0 0.844176 Retroperitoneum carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.221 CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.895595 ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8639 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06196 GSE228106_0_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230491 H3K27ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8426-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Aminoglutethimide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151078 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41576 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A196-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRIA4 Pathway Commons Protein-Protein Interactions 1.0 null Oral mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.048 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.84824 KB-92-MK13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.512405 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.942951 JA-23-QE71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.395647 GSE227698_5_v_0_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U3ZN-1626-SM-4DXTZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17735 HNF4A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-32-DP61_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248655 Tooth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.854 brain cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.088649 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26259 TNPO1 Pathway Commons Protein-Protein Interactions 1.0 null CA-42-YI34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.295218 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null organization GeneRIF Biological Term Annotations 1.0 null GSE161295_2_v_5_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE174735_4_v_3_il22_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OHPK-2526-SM-3MJH9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09817 MRE11A Pathway Commons Protein-Protein Interactions 1.0 null r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28803 CPS1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93485 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 77.9988 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.393 GSE150072,GSE169209_4_v_11_qser1_human RummaGEO Gene Perturbation Signatures 1.0 null MATR3 Pathway Commons Protein-Protein Interactions 1.0 null GSE223241_2_v_0_cdkn2a_human RummaGEO Gene Perturbation Signatures 1.0 null Dentinogenesis imperfecta DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.822 GSE205163,GSE205164_5_v_8_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SMARCA4 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R55D-1126-SM-48FEB GTEx Tissue Sample Gene Expression Profiles 1.0 1.26152 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949575 hsa-miR-510 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-QDVN-1026-SM-48TZA GTEx Tissue Sample Gene Expression Profiles 1.0 1.19819 UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12182 PC3 CCLE Cell Line Gene CNV Profiles 1.0 1.32976 ILF3 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_4259_KD|OE_HOXB13|MEIS1_SRP201342 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.30757 daudi HPA Cell Line Gene Expression Profiles -1.0 -1.61045 8505C_THYROID CCLE Cell Line Proteomics 1.0 4.52411 MCF7_AZ 960_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.018625 S0-EE-WJKI_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234033 GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null tooth enamel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.75374 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.886543 MIF Pathway Commons Protein-Protein Interactions 1.0 null CE-69-HJ13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.346691 A-Vietnam-1203-2004(H5N1)_3Hour_21865398_GSE28166 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.50761 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null PTBP3 Pathway Commons Protein-Protein Interactions 1.0 null decreased locomotor activity IMPC Knockout Mouse Phenotypes 1.0 null H3K36me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.4937 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-1226-SM-4E3HN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.973446 JHU-029 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.22369 frontalcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.927509 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WYVS-2526-SM-3NMAT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950512 MAX ENCODE Transcription Factor Targets 1.0 null GSE171724_4_v_6_ezh2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17297478-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null EIF4A1 Pathway Commons Protein-Protein Interactions 1.0 null GSE125014_6_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null DYNC1I2 Pathway Commons Protein-Protein Interactions 1.0 null CNOT6 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24123 FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.313474 FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCN3A Pathway Commons Protein-Protein Interactions 1.0 null A549_SNS-314 Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016693 NCIH929 CCLE Cell Line Gene CNV Profiles -1.0 -2.5187 ZIC5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 97.4149 SW837 CCLE Cell Line Gene Expression Profiles 1.0 1.3833 GSE216538_7_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6513 NCI-H64 COSMIC Cell Line Gene Mutation Profiles 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null abnormality of head or neck HPO Gene-Disease Associations 1.0 null PRPF6 Pathway Commons Protein-Protein Interactions 1.0 null CLOCK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0496 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GEMIN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7697 GSE169617_1_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null r10 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08916 GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43976 GTEX-RU72-0926-SM-2TF6B GTEx Tissue Sample Gene Expression Profiles 1.0 0.983534 PSMD2 Pathway Commons Protein-Protein Interactions 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36547 dorsal part of PcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78072 GSE180185_4_v_5_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13446 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal gallbladder morphology IMPC Knockout Mouse Phenotypes 1.0 null Tooth bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.19 HCC1187 COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 IRAK2_knockout_39_GSE10765 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.75245 UTRN Pathway Commons Protein-Protein Interactions 1.0 null Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48749 GSE241036_0_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null A704_KIDNEY CCLE Cell Line Proteomics 1.0 4.76065 GSE221327_8_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H6-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TUBA4A Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Sodium Phenylbutyrate_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125104 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.965486 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866387 GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null GSE87412,GSE92423_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.284607 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.498942 GSE99875_2_v_0_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKAG1 Pathway Commons Protein-Protein Interactions 1.0 null PRMT5 Pathway Commons Protein-Protein Interactions 1.0 null GSE254517_1_v_0_irf7_mouse RummaGEO Gene Perturbation Signatures -1.0 null NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null KB-78-BE93_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.508137 NALM-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null STMN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01007 XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Colon - Transverse GTEx Tissue Gene Expression Profiles 2023 1.0 5.24929 GSE110268_1_v_3_foxd1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE150055_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null snoutepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 PSMC2 Pathway Commons Protein-Protein Interactions 1.0 null ZNF326 Pathway Commons Protein-Protein Interactions 1.0 null GSE144231_2_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null MCF7_Droxinostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.020473 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23068 SCC-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null SKCO1 CCLE Cell Line Gene Expression Profiles 1.0 1.65585 MCF7_AICAR_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177466 GSE94849_6_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null Pancreatic carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 COPB2 Pathway Commons Protein-Protein Interactions 1.0 null brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.476835 DC-93-NP78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.335439 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIPK2 Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE142210_2_v_10_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33583 small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.116044 fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064547 GSE158197_6_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null RPL3 Pathway Commons Protein-Protein Interactions 1.0 null accumbens nucleus, core domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.98168 KTN1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041174 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null family GeneRIF Biological Term Annotations 1.0 null ZCCHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20895 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.743 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828011 olivary pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86026 LU-99A COSMIC Cell Line Gene CNV Profiles 1.0 2.41451 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.882267 Bone cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172