association	dataset	threshold value	standardized value
ZMPSTE24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01232
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893607
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.25
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87848
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37149
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
ChIP_SOX2_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22672
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
ERBB2_druginhibition_8_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.87931
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.86705
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.19999
H3K36me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.90647
RXRA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09076
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8067
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828936
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69123
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843396
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07152
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A25687296_EMETINE_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04605
ChIP_ESRRB_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21353
BRD-K06792661_Narciclasine_HEC108_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSFX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16229
HD-89-HC56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.568796
Proteinuria	CTD Gene-Disease Associations	1.0	1.51355
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221932,GSE222115_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA2_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92682
pallidal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22346
medial part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72263
chr22_43972159_T_C_b38	GTEx eQTL 2025	1.0	2.97843
CDC42SE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478773
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
HCC1599	GDSC Cell Line Gene Expression Profiles	-1.0	-3.50265
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.03899
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.371847
cellular macromolecule localization	GO Biological Process Annotations 2015	1.0	null
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44806
Prothylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.949713
bacterial-type flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.98
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K59045095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39494
2899_TASOR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542128
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
erythroid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.155634
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33591
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33125
SP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858377
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.941
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4762
Appendicitis_Appendix_GSE9579	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.95589
NANOG-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0557
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2C2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17891
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of immune system physiology	GWASdb SNP-Phenotype Associations	1.0	0.131084
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38696
BRD-K06576075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3279
periventricular part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32103
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18108
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PLAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678396
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84432
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.97487
Hydrogenosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.054
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138024_2_v_0_rgs4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Chloroplast thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
Alcoholic liver cirrhosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.032
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39021
ESRRB-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5021-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
septopallidal transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27226
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion organization	GO Biological Process Annotations 2023	1.0	null
BRD-K18385869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11358
Glanders	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.852
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.22878
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K49620695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61171
Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28587
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.805
BCLAF1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14639
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A2BAR_Deficiency_GDS3662_520_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K53241408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79113
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
urinary bladder cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268482
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.55208
CRCGN017_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04165
Barth syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
mitochondrial	GeneRIF Biological Term Annotations	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.697
intermediate stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01549
KLF4-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12907
BRD-K69158240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52844
Toc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.699
RAF1_overexpression_220_GSE42964	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.53619
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIRNA_EIF4GI	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.4198
BRD-K67531128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02182
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.064
mifepristone_homo sapiens_gpl6947_gse39654	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-0826-SM-32PM4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947557
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.48308
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37496
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.887682
YLPM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586789
central nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31502
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.03279
Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.0961
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.64638
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36852
BRD-A80502530_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27024
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68228
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23828
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLOT1	Pathway Commons Protein-Protein Interactions	1.0	null
KLF1	ChEA Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.572759
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
L-cysteine desulfurase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K27263328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42145
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF433	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44264
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.37446
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.4332
Food vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.41673
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Jurkat	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.79262
FBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047604
placenta	HPA Tissue Gene Expression Profiles	-1.0	-1.04391
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A361	BioGPS Cell Line Gene Expression Profiles	1.0	1.33372
GSE210093_0_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-10_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LAMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45117
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16963
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.75798
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WY7C-2726-SM-3NB3P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33102
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66845
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.503
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32755
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.85946
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911236
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	1.0	2.24804
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229932
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926059
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.767175
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48595
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29936
GNAQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42517
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Seizures	CTD Gene-Disease Associations	1.0	1.52938
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.56263
Brain Lower Grade Glioma_LGG_TCGA-DU-5870-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
20460173-ImmPortCD40LvsControl	GeneSigDB Published Gene Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.32402
Steatohepatitis	DisGeNET Gene-Disease Associations	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880878
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55439
abnormality of the abdominal organs	GWASdb SNP-Phenotype Associations	1.0	0.278249
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11162
Mitochondrial protein import	Reactome Pathways 2024	1.0	null
BRD-K26836050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10781
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39924
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YY1	ENCODE Transcription Factor Targets	1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.605711
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K36me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.403
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
BRD-K95768123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35399
CHST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46199
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34792
Intrinsic component of periplasmic side of cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.901
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	2.34648
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876096
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534855
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5608
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05596
Fatty Liver	HuGE Navigator Gene-Phenotype Associations	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51104732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73608
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.384
PMC4728380-ncomms10153-s8.xlsx-High_affinity_MYC_Targets-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5294
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
Substance Withdrawal Syndrome	CTD Gene-Disease Associations	1.0	1.03789
SIN3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33622
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.81335
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57414
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2458
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.709729
akr2b	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.866
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.0478
NCI-H526	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.60729
JHOC5	CCLE Cell Line Gene CNV Profiles	1.0	1.32806
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.89243
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Edema	HuGE Navigator Gene-Phenotype Associations	1.0	null
Intrinsic component of mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73968
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the systemic arterial tree	GWASdb SNP-Phenotype Associations	1.0	0.133964
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.837861
BRD-K82284644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81148
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of nucleobase metabolism	GWASdb SNP-Phenotype Associations	1.0	1.26441
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plastoglobule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8886
BRD-K35960502_NICLOSAMIDE_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100344_HIP_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02462
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.11351
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.779
olfactory tubercle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.951941
LDB1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
YARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68138
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385997
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0996
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051038
HYAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72902
BRD-K06237859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84833
G401_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	3.46616
Tripartite attachment complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.059
REST	ENCODE Transcription Factor Targets	1.0	null
SKMEL28	CCLE Cell Line Gene CNV Profiles	1.0	1.83518
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.827021
BRD-K13071687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19582
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08683
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-0426-SM-48TZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07976
BRD-K48408404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17493
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323318
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6133_OE_Tfeb_SRP157662	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.36848
BRD-K04853698_-666_HT115_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNCA	Hub Proteins Protein-Protein Interactions	1.0	null
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4768
LTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08412
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.429885
plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.2793
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35159
BRD-K69984954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03923
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thylakoid light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.738
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37786
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05221
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288008
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
implicated	GeneRIF Biological Term Annotations	1.0	null
KARPAS-299	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mantle zone of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72109
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06792661_Narciclasine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A19633847_PERHEXILINE MALEATE_COV644_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Plastid ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.953
BRD-K66039243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89306
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_10_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XD-44-FJ34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372514
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8071
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.428783
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.857757
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35196
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16789
KHSRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01868
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86586698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35394
BRD-K47984776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07288
ELF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K81801123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09534
ascospore-type prospore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.87607
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1503
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65774385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47501
mitochondrion organization	GO Biological Process Annotations 2025	1.0	null
BRD-K77782946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13602
GAK	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
r7 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72725
MDA-MB-175-VII	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15757
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591748
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior digastric muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07288
Biofilm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.285
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12	Pathway Commons Protein-Protein Interactions	1.0	null
NCOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21566
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91370081_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
breast	HPA Tissue Protein Expression Profiles	-1.0	-1.38397
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_126_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14653235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81388
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.840796
BRD-K75330923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96299
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.999077
Prelimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29773
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_H3K36me3_18692474_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330367
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4959-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver enzyme levels (alanine transaminase)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	4.5
XPOT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00465023
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.914036
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19524
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r2 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06145
BRD-K89931949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01096
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6009
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.089111
dh82	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.073
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2708
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	1.0	3.20849
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.605
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.50828
BRD-K76674262_Homoharringtonine_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17633
496100621_TCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07061
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18028
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15821
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40014
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7007
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19040732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29383
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314466
BRD-K68548958_-666_HA1E_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Endocrine gland cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55596
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U4B1-0126-SM-4DXSN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05644
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5815
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76397
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98244
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88583
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.07
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.13892
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.33956
medial part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43162
BRD-K35635568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40153
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
496100467_FWM_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17489
MDAMB435S	CCLE Cell Line Gene CNV Profiles	1.0	1.77129
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5156
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881814
BRD-K02301426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11003
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
r1 part of the 'mesencephalic' trigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00104
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.943208
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08994
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
placenta_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.96231
BRD-U86922168_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU410	CCLE Cell Line Gene CNV Profiles	1.0	1.78723
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.72981
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UBE2L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00439897
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10322
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11886
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062431
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09295309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05331
BRD-K48738035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51108
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_16_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
INPP5K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42234
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
benzydamine-1552	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.622639
GSE186654_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1608
Curli secretion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.69
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16496
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.77465
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04318
BRD-K46561246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15587
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215896
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330951
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.5723
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8338
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testosterone_mus musculus_gpl1261_gse17553	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.59505
metabolic process	GO Biological Process Annotations 2015	1.0	null
abnormality of prenatal development or birth	GWASdb SNP-Phenotype Associations	1.0	0.408757
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3485
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
CDC14A	Hub Proteins Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052802
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.343084
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51551
KAT2A	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.825357
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51044
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939265
10442_ZNF554_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574102
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42978
Lung squamous cell carcinoma_LUSC_TCGA-21-1077-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
flagellate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.607319
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244703
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828167
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cybrid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
disease	GWASdb SNP-Disease Associations	1.0	0.062349
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297659
BRD-K61029307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45644
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.136167
mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.36637
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.978
localization	GO Biological Process Annotations 2015	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1675
PBX3	ENCODE Transcription Factor Targets	1.0	null
RELA	ENCODE Transcription Factor Targets	1.0	null
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54955
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SARS-ddORF6_48Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.16813
LB373-MEL-D	GDSC Cell Line Gene Expression Profiles	1.0	1.67709
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14151
SALL4	ChEA Transcription Factor Targets	1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00905
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053995
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83270526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05708
r6 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30552
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08212
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70232
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.08062
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1517
BRD-K73523458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10253
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08161
Bam protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.901
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Chloroplast nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.898
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.50223
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
senescence-associated vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.281
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79522
BRD-K41307363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32598
BRD-K30655307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58417
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NR0B1	ChEA Transcription Factor Targets	1.0	null
BRD-K04887706_Akti-1/2_LOVO_6.0_h_9.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02779
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91370081_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle inner membrane	GO Cellular Component Annotations 2015	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
periventricular stratum of r6Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09095
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.89617
addition	GeneRIF Biological Term Annotations	1.0	null
GSE194358,GSE194361_0_v_1_kdm5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.23137
hsf1_17216044_hela_lof_human_gpl571_gds1733	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.971878
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.96182
MAPK1_knockdown_112_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.66901
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.65989
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18615
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6636
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-2W-A8YY-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAC2 GTPase cycle	Reactome Pathways 2024	1.0	null
those	GeneRIF Biological Term Annotations	1.0	null
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03124
DDX39A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.923803
Nemaline Myopathy_Gastrocnemius Muscle_GSE3384	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.64675
Fatty Liver	CTD Gene-Disease Associations	1.0	1.86132
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12756533-mmc1.pdf-20-SRF_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.297866
intracellular transport	GO Biological Process Annotations 2015	1.0	null
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87213231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87962
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BICR18	CCLE Cell Line Gene Expression Profiles	1.0	1.37947
KNS-42	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51228
SARS-dORF6_72Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.11472
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51096
single-organism organelle organization	GO Biological Process Annotations 2015	1.0	null
DDX39B	Pathway Commons Protein-Protein Interactions	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.38298
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842652
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45181
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5173-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.83767
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MRPL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24698
mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.471609
SOX17	ChEA Transcription Factor Targets	1.0	null
myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.119474
inner mitochondrial membrane organization	GO Biological Process Annotations 2025	1.0	null
protein localization to mitochondrion	GO Biological Process Annotations 2015	1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.526
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19667
16207381-Table1Sb	GeneSigDB Published Gene Signatures	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K52319351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5598
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25905181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59354
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC-10-05	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.89464
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAMA-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t-24 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.360036
cellular component organization	GO Biological Process Annotations 2015	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.88819
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.2588
GTEX-OXRK-0126-SM-3NB1E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20545
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045463
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.969131
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00095
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02196
Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26621
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.471
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47485
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPUL1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial outer membrane	GO Cellular Component Annotations 2015	1.0	null
Reticulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.502
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18714
amygdaloid complex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38611
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.302
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ps192	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.879
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045445
BRD-K80630598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56086
PKIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549001
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39W-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chloroplast outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.78847
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.650869
U-CH2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.14029
FGFR1_knockdown_94_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.74819
BRD-K84310612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01428
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46626
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71672234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06698
DEF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639671
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37596
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.58416
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21081
PMC2824905__F2	PFOCR Pathway Figure Associations 2023	1.0	null
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.869
abnormality of the placenta	GWASdb SNP-Phenotype Associations	1.0	1.26441
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.75398
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60796
mitochondrial outer membrane	GO Cellular Component Annotations 2023	1.0	null
SARS-BatSRBD_36Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.24047
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7979_SLC22A23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598413
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16865
H3K9me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5595
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885376
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1R11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12315
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
GTEX-X8HC-2826-SM-46MWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16857
gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.297866
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95946
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.395608
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.709235
Sarcoma_SARC_TCGA-MB-A8JL-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
CCT6A	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K14027855_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22728
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.44981
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441822
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
16597596-TableS1-4	GeneSigDB Published Gene Signatures	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K27849471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22699
GTEX-OHPK-1526-SM-3MJGM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825949
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4705
protein-containing complex assembly	GO Biological Process Annotations 2025	1.0	null
KNS-81-FD	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59368
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-HES6_HES6	Rummagene Transcription Factor Associations 2026	1.0	null
EMC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.31284
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70638
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894622
lateral terminal nucleus of the accessory optic tract, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5695
BRD-K01691949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58959
PRECLH	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22517
GSE248668_1_v_0_atxn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60041
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43731
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32489
Chloroplast envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.334
ENTPD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20714
FANCE	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47391428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07531
NOL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48978
PMC11903305-41586_2024_8507_MOESM3_ESM.xlsx-Table_S1_MAF-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82791632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67573
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.11326
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Obesity_Adipose tissue_GSE4692	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.965856
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03762
FOS	ENCODE Transcription Factor Targets	1.0	null
GTEX-S95S-0826-SM-4B64N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03653
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73888
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3496
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50532
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07902
Signaling by Rho GTPases	Reactome Pathways 2024	1.0	null
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ATPase dependent transmembrane transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.948
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.880555
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAPK14_knockdown_101_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.49613
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.471208
POLR2A	ENCODE Transcription Factor Targets	1.0	null
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46649
Cell wall-bounded periplasmic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.759
BRD-K69031148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60263
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IER5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87348
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.0876
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
Inner mitochondrial membrane protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
Hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.845211
icSARS CoV_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.67818
organic substance transport	GO Biological Process Annotations 2015	1.0	null
GPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04055
BRD-K78009480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20721
ATM_knockdown_113_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.43064
Nonalcoholic fatty liver disease	GWAS Catalog SNP-Phenotype Associations	1.0	0.255654
ILK_activemutant_78_GSE25729	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.55857
Nuclear MIS12/MIND complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.863
BRD-A24436948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14155
Lung squamous cell carcinoma_LUSC_TCGA-56-7580-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-Each_THP1_Pulldown_Expt_Targets-Unnamed_9_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.36895
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EFM192A_BREAST	CCLE Cell Line Proteomics	1.0	2.14477
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.042855
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41606
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RVH421	CCLE Cell Line Gene Expression Profiles	1.0	1.56278
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
BRD-K59049030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25262
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Sessile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31579
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Movement Disorders	CTD Gene-Disease Associations	1.0	1.01587
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-1526-SM-3P61M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886493
Zearalenone	CTD Gene-Chemical Interactions	1.0	null
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JHOM2B	CCLE Cell Line Gene Expression Profiles	-1.0	-2.06819
BRD-K28347985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62229
GSE136397_1_v_0_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Type II protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.86337
BRD-K24132293_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
IRF3	ENCODE Transcription Factor Targets	1.0	null
Cysteine synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.516
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
451Lu	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.23091
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.984456
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.957887
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06479
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.03182
cellular localization	GO Biological Process Annotations 2015	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.207451
SALE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47564
lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.32774
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.054186
GSE111102,GSE111105_8_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987259
Plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.337
PICK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39445
Lung adenocarcinoma_LUAD_TCGA-55-6986-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72414522_AZD-5438_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CYB5D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07817
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07267
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
ALLSIL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78281
mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.53783
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32209
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46072
GP5d	GDSC Cell Line Gene Expression Profiles	1.0	1.78039
coronary artery disease	GWASdb SNP-Disease Associations	1.0	0.74211
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16695519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27702
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0198
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Type I pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.058
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SH4	CCLE Cell Line Gene Expression Profiles	1.0	1.97678
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05582
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23458
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47437
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3653
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1081
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50371
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23932
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235429
lateral septal nucleus, intermedio-dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55603
BRD-K11251396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16298
PMC3470785-NIHMS377161-supplement-12.pdf-26-KDM5B_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
establishment of protein localization to mitochondrial membrane	GO Biological Process Annotations 2025	1.0	null
ESRRB	ChEA Transcription Factor Targets	1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.32182
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56682
BRD-A12166214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.092
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.212544
EZH2	ENCODE Transcription Factor Targets	1.0	null
samm50	GeneRIF Biological Term Annotations	1.0	null
FIZZ2_KO_GDS4902_408_mouse_Lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857214
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44256
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92565319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64516
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Taenia tecta, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13384
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.8824
EBF1	ENCODE Transcription Factor Targets	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.94135
GRIPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53713
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13426
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15656
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NF-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.4229
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01241
Signal Transduction	Reactome Pathways 2024	1.0	null
Gonorrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28596340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12333
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961105
Perturb_16602_KO_Alkbh5_SRP125927	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.47149
intermediate stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48963
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08175
GET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
BRD-A11702965_230752_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO741	CCLE Cell Line Gene CNV Profiles	1.0	1.66039
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
CB-32-EI69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384899
Lung adenocarcinoma_LUAD_TCGA-44-8117-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.369997
hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.297866
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51472
Sennetsu fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08864
BRD-K92569554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10686
SHP-77	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Hsf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.162
endomembrane system	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.486904
SOX2-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL27RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0046469
outer mitochondrial membrane organization	GO Biological Process Annotations 2023	1.0	null
mitochondrial membrane part	GO Cellular Component Annotations 2015	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
BRD-K73849129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29733
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10702478-jci-133-161348-s262.xlsx-High_targets8listes_TPM_DE-List_of_high_confidence_targets_of_PPAR_genes_regulated_after_18h_in_Mo_by_PA_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11696795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10734
colon	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.40078
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31279
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.59258
cellular_component	GO Cellular Component Annotations 2015	1.0	null
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890146
rough endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.13676
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858872
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23257
intracellular part	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Division septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.631
GTEx Lung 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-4.51454
Mitochondrial DNA depletion syndrome 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4364
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05332
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
beta-heterochromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.554
describes	GeneRIF Biological Term Annotations	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.41904
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061036
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-2.00608
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K88328128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49968
intracellular protein transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
9526_UBE3C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.554521
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613581
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A20248179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07606
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10152
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
Kidney Chromophobe_KICH_TCGA-KN-8436-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51595
pelvis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.912653
amoxicillin_rattus norvegicus_gpl341_distal small intestine_gds1273	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K87595216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73998
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01888220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06772
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0435
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.567
NCIH1155	CCLE Cell Line Gene CNV Profiles	1.0	1.40218
SK-MEL-5	GDSC Cell Line Gene Expression Profiles	1.0	2.25642
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.096639
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20397
BRD-K02987495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04144
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.140157
FOXM1	ENCODE Transcription Factor Targets	1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893551
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02342
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17634
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939766
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27976
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.92802
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Starch grain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.628
7645_SAMM50_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.747539
mitochondrial outer membrane translocase complex	GO Cellular Component Annotations 2023	1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.667
CRCGN016_MCF10A.TP53.M_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03003
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14082333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62551
OVCAR-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.08856
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
membrane-enclosed lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.09998
TRIM21	Hub Proteins Protein-Protein Interactions	1.0	null
bed nucleus of the stria terminalis, medioseptal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16535
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34475
r3 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40105
transport	GO Biological Process Annotations 2015	1.0	null
layer 6 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11984
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
MYBL2	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of CoPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56626
Mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.679
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.953
GTEx Heart 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-8.34068
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93829
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4148
T3M4	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.23595
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
single-organism cellular localization	GO Biological Process Annotations 2015	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20323
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MIB complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Nonalcoholic Steatohepatitis	DisGeNET Gene-Disease Associations	1.0	null
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K35432283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02943
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19039785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02924
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.656342
BRD-K28691459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11412
Brain Lower Grade Glioma_LGG_TCGA-P5-A72Z-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.7349
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.925
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFS8	Pathway Commons Protein-Protein Interactions	1.0	null
GJC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618317
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
COLGALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15634
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6318
Type 2 diabetes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.952288
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
BRD-K31013025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11112
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.17631
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.97
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11949
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC88B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08583
FGD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02416
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3911
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
C1orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52051
CRCGN013_HEPG2_24H:H20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23021
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0226-SM-4DM6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15383
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22870904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08743
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.77968
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.73488
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977913
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.42937
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.125415
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	1.49683
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38461
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45645
Creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
GTEX-RUSQ-0326-SM-47JWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850638
MITF	ChEA Transcription Factor Targets	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.100912
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77481
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.172
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4608010-srep15184-s1.xls-geneSets_HAN_SATB1_TARGETS-HAN_SATB1_TARGETS_DN_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.0957
CR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478732
GSE116810_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13235
terminal nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05873
EJM	CCLE Cell Line Gene CNV Profiles	-1.0	-2.41389
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pasteurellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
H3K9me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.59119
BRD-K10761381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05575
BRD-K31462164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16514
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.174425
Cytosolic proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.982
MTX2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41137
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.682546
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33846
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14051
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.94103
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463601
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-1.96146
Type 1 diabetes mellitus_Muscle - Striated (Skeletal) (MMHCC)_GSE1659	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.12418
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10079688-41467_2023_37633_MOESM7_ESM.xlsx-IP_JUN_in_WT_vs_sgJUN_cells-Supplementary_Data_4_List_of_interactors_of_JUN_identified_by_label-free_quantitative_proteomics_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60181
NCI-H1734	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.42366
BRD-K84613654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24425
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.53622
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8096-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.23242
BRD-A52650764_Ingenol 3, 20-dibenzoate_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49211735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50348
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7012
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10525
mantle zone of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00277
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99252563_QL-XII-47_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.595
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KURAMOCHI	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.73256
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.74811
BRD-K26559753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11791
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.960315
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89814
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.231795
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
NCI-H524	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.83639
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A-61603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44944
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7031
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89978
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17618
r7 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27071
BRD-K42457027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41674
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.47241
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19241
Sarcoma_SARC_TCGA-Z4-A9VC-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EJM	CCLE Cell Line Gene Expression Profiles	-1.0	-2.53845
SK-MEL-28	GDSC Cell Line Gene Expression Profiles	1.0	3.05189
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.62
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.871123
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.740515
PTHrP_KD_GDS1664_71_human_MDA-MB-231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.74914
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SPAG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14423
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.87792
intermediate stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07601
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.36104
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal tooth morphology	IMPC Knockout Mouse Phenotypes	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02089
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K66715657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29145
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876048
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8177-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.0741
Lung adenocarcinoma_LUAD_TCGA-78-7150-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
CXorf23	Pathway Commons Protein-Protein Interactions	1.0	null
SLC18A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17957
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.557236
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2975
Lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08304
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
Microbody membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NR2C2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21844
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.50615
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53201
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81651477_Parthenolide_VCAP_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Apical bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t56-vastus-lateralis_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.69434
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34751
Astrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
Cell septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.577
organelle membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.449245
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24044
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial septal complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32735
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondria-associated endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.001
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.98729
Nucleus dentatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261341
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24709
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877478
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10324
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.03872
outer SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02239
BRD-K40223625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11845
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.1427
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25948
Lung adenocarcinoma_LUAD_TCGA-78-7536-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.785558
BRD-K07928699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34622
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.87382
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.38987
GSE210655_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_131_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11068
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.71374
Integral component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.746
BB-77-QQ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220416
Hepatobiliary system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ps94	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.628
Chromoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.313
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248348
SYK_knockdown_189_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.5461
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79748783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08742
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.934695
leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.0578
SARS-BatSRBD_96Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.65009
BRD-K84595254_Strophanthidin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.09125
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37496
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.4827
BRD-K03816923_Rottlerin_HEPG2_6.0_h_9.68_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung_3e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12023
inner CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.916173
ZNF727	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75932
Bmi1_Deficiency_GDS4816_323_mouse_Primary lung cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE231648_0_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_6_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95323755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37461
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	5.01265
BRD-K82397896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40121
SIN3A	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41739
HIF1A_NULL MUTATION_GDS1648_764_mouse_Hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-20-OG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213737
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-M86331534_BJM-ctd2-9_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02023
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
abnormality of the liver	GWASdb SNP-Phenotype Associations	1.0	0.382981
GSE111102,GSE111105_3_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERH	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987644
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of circulating protein level	GWASdb SNP-Phenotype Associations	1.0	1.26441
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Cristae formation	Reactome Pathways 2024	1.0	null
ursodeoxycholic acid_mus musculus_gpl8321_gse21266	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anteroventral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79614
PMC5214989__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K26459891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39747
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.74152
ChIP_SALL4_18804426	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K52634604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43919
BRD-K30379413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0733
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062971
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12693
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50132
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
Type IV secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.879
Extracellular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE193588_1_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KNS81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56506
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.04181
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.28473
COLO678	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88884
SCA1_Knock-in_GDS1756_233_mouse_Forebrain tissue - 4 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
myocardial infarction	GWASdb SNP-Disease Associations	1.0	1.44051
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.849315
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN013_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4303
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48952
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.92456
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.72517
bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.474498
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45858
Cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
phenylpropanolamine-1602	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.06134
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
abnormalities of the peripheral arteries	GWASdb SNP-Phenotype Associations	1.0	0.23832
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06283
PMC5214989__F2	PFOCR Pathway Figure Associations 2023	1.0	null
dichlorophen	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04263
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15216
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.777265
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51827
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25051
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07948
Liver cirrhosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.05
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363889
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507422
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.77552
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.21424
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35019
contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.346071
Mitochondrial protein import	Reactome Pathways 2014	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52428486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41187
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.03045
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.3901
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58275
CRCGN013_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50897
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6999
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04883
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.09265
biological_process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02916
Human granulocytic anaplasmosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
BRD-A75144621_digoxin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K67284043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24547
Diagonal band nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34153
dorsomedial preoptic area, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41668
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881816
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6SX-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP2R2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622733
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69932463_AZD8055_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34761198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51468
muscle	GTEx Tissue Gene Expression Profiles	1.0	1.73705
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39449
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K46639367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10468
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832504
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.51318
CDK8_knockdown_88_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.08097
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211633
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07347
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.25105
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XYKS-0926-SM-4BRVG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869832
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.876239
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein insertion into mitochondrial outer membrane	GO Biological Process Annotations 2025	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S14-Table_S14_MR_resluts_of_brain_pQTL_and_cardioembolic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJMC-0626-SM-4IHJQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852534
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4903-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.28712
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lipid accumulation in hepatocytes	GWASdb SNP-Phenotype Associations	1.0	1.67588
intestinal benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.282582
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner mitochondrial membrane organization	GO Biological Process Annotations 2023	1.0	null
GSE127790_9_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pirenzepine-1388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MBD4	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-0926-SM-4DM4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01041
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
FAM208B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE149903_6_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gut microbiota (bacterial taxa, hurdle binary method)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
horizontal nucleus of the diagonal band, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47797
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98008739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1128
Perturb_10438_Mut_Adad2_SRP262140	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.90415
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
GATA2_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31721388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28171
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12833
NCIH292	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49452
mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7318-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
KARPAS-620	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.45796
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A67788537_Salermide_A549_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K88441035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12025
BRD-K35863275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14212
Lung squamous cell carcinoma_LUSC_TCGA-60-2723-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
BRD-A67788537_Salermide_HA1E_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063303
HMGN3	ENCODE Transcription Factor Targets	1.0	null
GTEX-V1D1-1726-SM-4JBHB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946735
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.932
NCI-H226	GDSC Cell Line Gene Expression Profiles	-1.0	-2.1606
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5180-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AIMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34851
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.555675
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887778
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.562187
PMC4821877-ncomms10846-s9.xlsx-THP1_Splice_events-Gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
MOLP-8	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.23003
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89814
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61641
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934391
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33924
GSE255680_2_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rectal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.492359
chr22_43989799_CTGTT_C_b38	GTEx eQTL 2025	1.0	1.04097
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8304-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.72525
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3799
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860401
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYA	ENCODE Transcription Factor Targets	1.0	null
NACC1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormality of nitrogen compound homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.408757
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
TIA1_KO_GSE54418_267_mouse_spinal cord	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
FADU_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	3.09288
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34901
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GABP-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RAJI	CCLE Cell Line Gene Expression Profiles	1.0	1.4429
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.41301
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.27875
non-alcoholic fatty liver	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
Infertility, Male	CTD Gene-Disease Associations	1.0	1.34285
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1417
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.89784
143B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
BRD-K12067186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56092
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86240647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50944
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
BRD-K79221878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41467
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.353621
pasteurellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.758601
Penis_Foreskin_Melanocyte_Primary_Cells_skin03	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.29638
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72825
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.742
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.267813
BRD-K13566078_HY-10518_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.779
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210655_1_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H3122	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Supratrigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34575
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial geniculate nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887005
rostral secondary prosencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13566
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.729877
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.954204
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39978
DSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12545
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5HB-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62418398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5944
BRD-K95365728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18961
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y6-01A-21R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
erythroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.155634
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.53433
SYK_druginhibition_286_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.91564
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-71-BZ81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264601
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76674262_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE185881,GSE185884_2_v_3_ctcf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4505
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09166899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02213
ABC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.97948
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.99
terminal hypothalamus (rostral hypothalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04168
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.997115
UGCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481266
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5933
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02951
bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.19717
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291661
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	0.971107
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07056
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836425
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04575
OXCT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00290277
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6391
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.9229
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11115
BRD-U08759356_EI-346_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
mycophenolate mofetil_homo sapiens_gpl4133_gse45485	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49325049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04538
BT483	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56696
PLK2_knockdown_87_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.90284
HCC2935	CCLE Cell Line Gene CNV Profiles	1.0	1.51007
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
coronary artery disease	GWASdb SNP-Phenotype Associations	1.0	0.641033
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.33183
Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.74713
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.831005
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.911969
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958235
HDAC11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547477
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495046
Fetal Death	CTD Gene-Disease Associations	1.0	1.16933
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55603
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.551
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27744
GATA1-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K33710385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60694
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
establishment of protein localization to mitochondrial membrane	GO Biological Process Annotations 2015	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17853
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.9748
superficial stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2689
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27829
EVSAT	CCLE Cell Line Gene Expression Profiles	1.0	1.38551
Lung transplant rejection_Lung Tissue_GSE2018	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.45447
BRD-K10871135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59816
BRD-K37906761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.013
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3682
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SQRDL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23461342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18808
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8192
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02781189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10025
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.45367
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.41078
Skin disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.034
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
ALAS2_OE_GDS2118_74_human_Blood	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NACC1	ChEA Transcription Factor Targets	1.0	null
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63858
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02331
BRD-K91575768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54833
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34644
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3771
LI7	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93572
periventricular stratum of Ist	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11483
NDUFB8	Pathway Commons Protein-Protein Interactions	1.0	null
WT1_01_08	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.89278
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20211
Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Eye Diseases	CTD Gene-Disease Associations	1.0	1.01286
Chromoplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormalities of placenta or umbilical cord	GWASdb SNP-Phenotype Associations	1.0	1.26441
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.764839
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.7307
CDC37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624853
SNB19_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	4.25602
import	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
PSII associated light-harvesting complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46668
BRD-K18316646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22099
USF1	ENCODE Transcription Factor Targets	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32477623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03709
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4444
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4374
GSE143994_0_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
NCIH292	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7469
Gamma-hydroxybutyric acidaemia_CNS - Brain - Hippocampus (MMHCC)_GSE2866	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.80874
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.09541
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integral component of mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
oculomotor nucleus, Edinger-Westphal subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05719
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44596
Lung adenocarcinoma_LUAD_TCGA-97-8547-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35291
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_92_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1319
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.45437
Lung adenocarcinoma_LUAD_TCGA-05-4427-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VV-A829-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATG12	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K64418159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34934
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.49525
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12408
meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.845031
Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular protein localization	GO Biological Process Annotations 2015	1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27533
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437096
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49278
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86344
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.804313
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S12-Table_S12_MR_resluts_of_brain_pQTL_and_any_ischemic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
EJM	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.02211
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20234
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.912685
PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rectum adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.883521
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131915
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207914_2_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.278
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330782
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondria	GeneRIF Biological Term Annotations	1.0	null
METTL2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12403
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02089
MFE296_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.21539
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.20196
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.40339
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_84_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
SNU478	CCLE Cell Line Gene CNV Profiles	1.0	1.38243
viral infectious disease	GWASdb SNP-Disease Associations	1.0	0.347201
NCIH1930	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59424
ZNF713	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0261
Lateral septal complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00428
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.567
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.211261
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
zona incerta	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.938061
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.997747
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WRHU-0226-SM-3MJFV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910053
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81868
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.235
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986223
BRD-K30917841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15367
Congenital myasthenic syndrome 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
intermediate stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74911
CUX1	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KINGS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.963902
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5696-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82399478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66945
Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r4 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02809
r7 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24791
3-CPMT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34505
AMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13393
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A767-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41825
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal bone structure	GWASdb SNP-Phenotype Associations	1.0	0.212544
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.491
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960654
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE243491_1_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
USB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505082
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43488
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.17131
protein localization	GO Biological Process Annotations 2015	1.0	null
DUSP1_Deficiency_GDS1606_765_mouse_Spleen	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942955
Cardiac Hypertrophy_Myocardial tissue_GSE1621	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.85595
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24907
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34717
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66470464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13177
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.867673
BRD-K85110576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36231
Gingival fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.7782
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982765
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0101
septopallidal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8756
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HE-80-BQ08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214769
Mitochondrial intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.094
KRTAP5-8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501606
ART4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513879
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.645
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83241
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hepatitis, Autoimmune_Hepatic Tissue_GSE867	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.36944
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.063
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.409
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-1126-SM-48FDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950451
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.837862
Brain Lower Grade Glioma_LGG_TCGA-E1-5318-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spiperone-1559	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r6 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09235
Protein localization	Reactome Pathways 2024	1.0	null
BRD-K52037352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38228
Brain Lower Grade Glioma_LGG_TCGA-DB-A64O-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09859
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2129
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15037
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047447
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Leaflet of membrane bilayer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.72
SPI1-20517297-HL60-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.980513
GTEX-P44H-1126-SM-48TBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871206
BRD-K98264372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55119
ACHE_OE_GDS891_241_mouse_Prefrontal cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61459
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94388
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.14187
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49586
outer mitochondrial membrane organization	GO Biological Process Annotations 2015	1.0	null
arteriosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.265621
BRD-K85851814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1435
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12998
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A-CA-04-2009(H1N1)_24Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.17354
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.95893
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.07365
fetus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923901
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481673
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223758
mitochondrion organization	GO Biological Process Annotations 2015	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59139
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63213
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.87756
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2444	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01403
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.15532
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.982593
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.35618
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cephalothin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46047
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42584
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mental Disorders	CTD Gene-Disease Associations	1.0	1.27936
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6-chloromelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49459
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
Ehrlichiosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00134
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Non-Alcoholic Fatty Liver Disease	DisGeNET Gene-Disease Associations	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.01689
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Signal recognition particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967787
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basolateral nucleus (basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15614
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-2.06178
Cystic Fibrosis_Intestinal Epithelium_GSE765	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.50627
IF-03-OL58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20464
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.83596
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071554
BRD-K25408656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5902
BRD-K26232524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29021
PPARA-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Type V protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.78
Cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.509
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.64766
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.66199
SKMEL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49255
hl60	HPA Cell Line Gene Expression Profiles	1.0	2.55271
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cristae	GeneRIF Biological Term Annotations	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593085
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.588529
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12616
Liver cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
ITGA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481198
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.05089
Myocardial Ischemia	DisGeNET Gene-Disease Associations	1.0	null
BRD-A26583774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03169
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95685_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67944
HDAC1	ENCODE Transcription Factor Targets	1.0	null
BRD-K51897928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93478
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74317118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19812
HCC1599	CCLE Cell Line Gene Expression Profiles	-1.0	-3.99892
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7106
Plastid inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.974
NR2C2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
natural killer cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.22778
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981783
GSE140965_2_v_3_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K85622666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17781
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
establishment of protein localization to membrane	GO Biological Process Annotations 2015	1.0	null
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A76X-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.04647
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.100912
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7589-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.894323
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.297866
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.31446
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06803
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48513
GAK	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.16365
Dental plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.936358
BRD-K64748422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11759
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bacterial biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.885
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33854
ChIP_RCOR3_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04172
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.338
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bacteriocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99771
Meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.523
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415279
mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.960707
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FADU	CCLE Cell Line Gene Expression Profiles	1.0	1.88916
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03036
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.58685
Extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NCBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00811872
endoplasmic reticulum part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.709251
MFSD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00414686
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3189
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.572299
BF-27-HP68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257125
outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT-29	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52734
Nuclear type mitochondrial complex I deficiency 33	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515759
Lateral septal nucleus, caudal (caudodorsal) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41979
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12469
BRD-K68056389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49358
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2142
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89814
Craniofacial Abnormalities	CTD Gene-Disease Associations	1.0	1.06771
ZNF563	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82976
maintaining	GeneRIF Biological Term Annotations	1.0	null
BRD-K13085116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66391
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06377
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06764
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK6_knockdown_93_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.2169
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20721
KLF4-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.952556
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.671593
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.953093
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954228
GTEX-WFON-1126-SM-4LVMA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943083
protein targeting to mitochondrion	GO Biological Process Annotations 2023	1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-15-RC31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261061
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.945188
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213284
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24512
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03927
FBXO11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00464022
BATF	ENCODE Transcription Factor Targets	1.0	null
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.382
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GATA1-19941827-MEL86-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K79322550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2036
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.08191
BRD-K53993775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02615
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.766804
CEBPB_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	2.15204
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06474
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41833
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18619
R3HDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25227
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chlamydia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K11010670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10707
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40488
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
BRD-K72125659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07358
periventricular stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16627
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30977850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39153
LCLC103H	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12141
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77305
GTEX-QDVN-1226-SM-48TZ5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824011
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H446	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.01415
cell part	GO Cellular Component Annotations 2015	1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4291
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SARS-BatSRBD_84Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.38859
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58104
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.1526
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
FADU	CCLE Cell Line Gene CNV Profiles	1.0	2.79662
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31969
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S7-MECOM_up_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8T8-1226-SM-4E3IH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892011
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02509
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26093
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883819
BRD-K17140735_-666_MCF7_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fatty liver disease	GWASdb SNP-Disease Associations	1.0	1.78054
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267682
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.202
BRD-K62935946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20117
BRD-K27335290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25511
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1141
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K41207293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.83823
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.973013
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07683
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7536
Heterocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.762
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.847
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleomorph	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.416
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4415-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048567
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53156
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUZC-0226-SM-4BOO7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1029
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-Duck_gene_name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_139_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.141288
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02152
H3K23ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882679
Brain Lower Grade Glioma_LGG_TCGA-DU-6397-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-Fig_1_B_THP1_Pulldown_Targets-Unnamed_1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PLZ5-0326-SM-3P614	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05122
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832589
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06518
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver enzyme levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.50969
BRD-K74305673_IMD 0354_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	1.22489
GTEX-PW2O-0226-SM-48TC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06996
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965406
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2779
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899348
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	1.0	3.26663
sc71	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gerontoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.55
GSE245270_2_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255742
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20336
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825317
membrane organization	GO Biological Process Annotations 2015	1.0	null
GRM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539252
BRD-K26122955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29831
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
Hepatitis B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67795
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CGREF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32092
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.89972
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.931
anionselective	GeneRIF Biological Term Annotations	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.64829
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71318
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.52425
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15105
organelle organization	GO Biological Process Annotations 2015	1.0	null
BRD-K16643911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84358
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839517
amygdalohippocampal transition zone, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41426
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.96188
BRD-K11782435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11034
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07416
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.09813
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
Signal peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.548
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45535
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32755
CTSK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625736
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.03789
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64445
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28852
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.878726
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33009
BRD-K44100512_KIN001-043_BT20_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_417_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15245
mitochondrial sorting and assembly machinery complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
organelle outer membrane	GO Cellular Component Annotations 2023	1.0	null
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
Pediatric non-alcoholic fatty liver disease activity score	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.9699
DB-18-UF01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236451
TAF1	ENCODE Transcription Factor Targets	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12223973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12918
ANKS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16521
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.133737
involves	GeneRIF Biological Term Annotations	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17555
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12251
Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3798
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
gastrointestinal system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.175411
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95852319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70128
fipexide-1560	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
atherosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.300627
MELHO	CCLE Cell Line Gene Expression Profiles	1.0	2.80562
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14345
Cco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38322
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.30535
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982765
MRTO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94735
PIK3CG_knockdown_96_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.51153
CFLAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00426713
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RXRA	ENCODE Transcription Factor Targets	1.0	null
BRD-K61796560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11797
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AK5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Amyloplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.049
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876651
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A43076080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50137
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30385
Fatty Liver Disease	DisGeNET Gene-Disease Associations	1.0	null
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A26199074_2561_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890886
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.08495
intracellular protein transmembrane import	GO Biological Process Annotations 2015	1.0	null
inherited metabolic disorder	GWASdb SNP-Disease Associations	1.0	0.396422
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6770-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	68.55
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95008
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40208
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5984-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18181387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4877
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALL-SIL	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.57336
r7 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27757
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.711667
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86711517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14544
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237237
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATA1-19941827-MEL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K37356599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30844
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44351
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.809414
baf8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78773
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01982
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51316
LCLC103H	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19991
SKMEL5	CCLE Cell Line Gene Expression Profiles	1.0	1.42599
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.46518
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0835
BRD-A34806832_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3210_KD_CNOT3_SRP117693	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.3502
Hepatocellular carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory chain complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.398
abnormality of cholesterol metabolism	GWASdb SNP-Phenotype Associations	1.0	1.26441
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal peduncular cortex, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41517
BRD-K36847650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21605
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51107
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6167
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.879
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.9485
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10764
H3K36me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIAA1549	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0943
GATA1-19941827-MEL-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CLN3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854691
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17208
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pallidum, medial region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36635
CI1	CCLE Cell Line Gene Expression Profiles	1.0	1.39778
TOMM22	Pathway Commons Protein-Protein Interactions	1.0	null
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392219
binding	GO Molecular Function Annotations 2015	1.0	null
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.911
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.969
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38442
UACC257	BioGPS Cell Line Gene Expression Profiles	1.0	1.25888
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160373_5_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24662
mitochondrial membrane organization	GO Biological Process Annotations 2025	1.0	null
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Esophagus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.20691
Type VI protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r7Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15371
PANK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667646
BRD-K72060858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18536
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876651
BRD-K04635516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73524
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96077
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
diethylstilbestrol_mus musculus_gpl81_gse1839	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K28813194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3792
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28737
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68496
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42145
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carboxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.652
protein binding	GO Molecular Function Annotations 2015	1.0	null
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SARS-CoV_84Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.64473
mood disorder	GWASdb SNP-Disease Associations	1.0	0.291976
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cholestasis	CTD Gene-Disease Associations	1.0	1.25059
BRD-K77634326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24394
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45948
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormality of the abdomen	GWASdb SNP-Phenotype Associations	1.0	0.255902
artery disease	GWASdb SNP-Disease Associations	1.0	0.260755
BRD-K24206299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13342
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03816923_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07665396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13816
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564691
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17605
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910732
RHO GTPase cycle	Reactome Pathways 2024	1.0	null
BRD-K84788922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06543
ZNF540	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16356
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26193
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.683335
CVB3_3Hour-Infection_None_GSE697	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.84266
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14806
ermes complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.759978
Pyrenoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
GSE198165,GSE198166_7_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Metabolic dysfunction-associated steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
Proplastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.456
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58683
BRD-K47947160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53574
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38928
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15757
A-549 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.893251
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5595
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NDUFS3	Pathway Commons Protein-Protein Interactions	1.0	null
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.90022
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.754809
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S13-Table_S13_MR_resluts_of_brain_pQTL_and_large-artery_atherosclerotic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58409
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5174-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23222
isthmic part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11408
NRL_Deficiency_GDS2936_630_mouse_Retinas - 10 days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892529
protein targeting	GO Biological Process Annotations 2015	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983903
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.80569
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.059
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Macrolide transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.583
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04008
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IGR37	CCLE Cell Line Gene Expression Profiles	1.0	1.77624
NANOG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00452763
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70535
Idiosyncratic drug effect_Hepatic Tissue_GSE2825	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.48987
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23560817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16116
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitophagy - animal	KEGG Pathways 2026	1.0	null
urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109208
GSE62843,GSE64370_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6895612-EMMM-11-e10835-s005.xls-Overlap-Exogenous_circ-CUX1_MS_CUX1	Rummagene Transcription Factor Associations 2026	1.0	null
estradiol_homo sapiens_gpl570_gse16683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prostate gland	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.27317
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KCNJ10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518024
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02418
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7078
Kinetoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94974
intermediate stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40024
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
peripeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09956
SP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0527
ChIP_KLF4_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K97869597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25331
Suprageniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41206
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27226
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nafld	GeneRIF Biological Term Annotations	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
Mitochondrial processing peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.474
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Male urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
BRD-K26051127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12286
Plastid nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39835
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9762
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052305
HOP-62	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896564
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
TP63_01_199	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.65024
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835587
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993848
SKMEL28	CCLE Cell Line Gene Expression Profiles	1.0	2.54856
6574_POP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551246
COS-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
Vomiting	CTD Gene-Disease Associations	1.0	1.15627
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.645317
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48670593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3335
membrane part	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.75019
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.628176
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0776
Coronary Disease	dbGAP Gene-Trait Associations	1.0	0.111214
tRNA-intron endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.636
BRD-K04853698_-666_HCT116_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98506
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94523
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.863242
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874161
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04509
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06825
PMC2824905__F2	PFOCR Pathway Figure Associations 2024	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27017
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920713
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21394
Oligospermia	CTD Gene-Disease Associations	1.0	1.30727
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
abnormality of the coronary arteries	GWASdb SNP-Phenotype Associations	1.0	0.300627
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
Planktonic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.372
12734205-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K68347834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20368
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27600134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27728
PU.1-20513432-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0126-SM-4DXTP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951345
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
29-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
PMC10290283-biol-2022-0622-sm3.pdf-448-BSX_BSX	Rummagene Transcription Factor Associations 2026	1.0	null
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22044
cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.250389
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03491
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37335
cytoplasmic transport	GO Biological Process Annotations 2015	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26964
Learning Disorders	CTD Gene-Disease Associations	1.0	1.46727
L-428	GDSC Cell Line Gene Expression Profiles	1.0	1.81609
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30377
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.905342
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221386_2_v_0_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2941
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COLO-741	GDSC Cell Line Gene Expression Profiles	1.0	1.48265
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246225
PPIL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00777375
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.18017
BRD-K06792661_Narciclasine_SKMEL1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.59526
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90806964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54098
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APLP2_KO_GDS4414_534_mouse_adult cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68857
GTEX-WEY5-1926-SM-3GIL8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853151
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33766
Lung adenocarcinoma_LUAD_TCGA-78-7147-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsomedial preoptic area, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84357
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29711
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A3RK-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03428
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0274
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JCHAIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551751
t55-gastrocnemius_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.41752
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.9119
septostriatal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.31284
CAL148	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58316
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
MOLT-16	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.40632
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r1Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45815
Inherited metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.92456
GTEx Lung 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-9.22455
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48235533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55128
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
retropontine reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0455
mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.438146
TCF3	ENCODE Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29037
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Leptospirosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.980745
Periplasmic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.723
COLO849	CCLE Cell Line Gene CNV Profiles	1.0	1.65509
BRD-K13206026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13454
RH-18	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.09903
PMC8076345__F3	PFOCR Pathway Figure Associations 2024	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anorexia	CTD Gene-Disease Associations	1.0	1.08301
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.713
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78543
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH596_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402043
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0185
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_136_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.751083
SEC24A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26795
Commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NL4W-0011-R2a-SM-2I5GV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826197
BRD-K72636697_QL-X-138_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TFAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20794
CYC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.861472
lipid storage disease	GWASdb SNP-Disease Associations	1.0	0.855495
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29M-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2717
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUPT11	CCLE Cell Line Gene Expression Profiles	1.0	1.47157
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37506332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38431
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41548
SK-MEL-28	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.98849
liver	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.878474
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207711
mitochondrial outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
establishment of protein localization to organelle	GO Biological Process Annotations 2015	1.0	null
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Unnamed_2_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31727
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210476_9_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27982
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
abnormality of thrombocytes	GWASdb SNP-Phenotype Associations	1.0	0.378764
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A67788537_Salermide_HT29_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
HCC1195	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86922
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874442
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
human granulocytic anaplasmosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.648533
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995273
KEL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512707
H3K23ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4583
JHH7	CCLE Cell Line Gene CNV Profiles	1.0	1.49051
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.38889
Cell envelope Sec protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.165
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217395
ATN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37464
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.86895
Motor nucleus of trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16843
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT4_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.73549
normoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.155634
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Cytochrome b6f complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
BRD-K90526956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08268
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nectary	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
Kidney Chromophobe_KICH_TCGA-KL-8335-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17371
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06229
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217363_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
mitochondrial membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17641
BRD-U51951544_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A96007399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01865
A549_G007-LK_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161289
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colonic cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IA-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32127177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15133
NRF1	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Perturb_5162_KD_Mbd2_SRP051519	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.44569
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	1.0	2.12843
M6PR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.502
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07933
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77922263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1357
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10023
BRD-K22875065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26175
BRD-K19295594_-666_A549_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13515
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-M86331534_BJM-ctd2-9_SKMEL28_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11589884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19652
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.46483
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875359
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33127
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K42663371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45943
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12973_KO_IGF2BP2_SRP365416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9237
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.995647
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q8-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein insertion into mitochondrial outer membrane	GO Biological Process Annotations 2023	1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.740515
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KAP1-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56857396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05558
protein targeting to mitochondrion	GO Biological Process Annotations 2025	1.0	null
CDKN1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4731
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.950636
bacterial-type flagellum hook	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.521
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intermediate stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46598
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00656
TOMM40	Pathway Commons Protein-Protein Interactions	1.0	null
NBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36612
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19667
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.953196
BRD-K64823749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23621
protein localization to organelle	GO Biological Process Annotations 2015	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056313
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18109695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08311
TMEM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06829
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SENP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06297
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893938
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51247
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cls1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
GSK3A_knockdown_201_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.57564
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K13436682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13182
Bacterial meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
SOX2-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MISP	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13514097_S1120_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
plasma levels of liver enzymes	GAD Gene-Disease Associations	1.0	null
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.38745
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23846
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54161
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.554
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36659
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FEM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11803
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A52193669_2816_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K25658788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33057
POU5F1-18700969-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.930642
abnormal platelet count	GWASdb SNP-Phenotype Associations	1.0	1.26441
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.97238
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884096
KIF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67051
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3017
abnormal hemoglobin	GWASdb SNP-Phenotype Associations	1.0	1.26441
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.297866
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4853-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902582
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.7675
medial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81604
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.973
Mitochondrial biogenesis	Reactome Pathways 2024	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.976292
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22024
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09509
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_35_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923865
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.824041
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.08055
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24002
BRD-K32043305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14004
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23923
APLP2_KO_GDS4414_371_mouse_prefrontal cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4404
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A72E-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.215797
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2206
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49753
Memory Disorders	CTD Gene-Disease Associations	1.0	1.25745
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3661
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJHI-0226-SM-4IHJL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835416
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203099
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.831889
EIF3I	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
7690_SCD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557504
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.09509
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.672166
12734205-TableS4	GeneSigDB Published Gene Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07662
SAM complex	GO Cellular Component Annotations 2023	1.0	null
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06631
Alexander Disease_CNS - Brain - Olfactory Bulb (MMHCC)_GSE977	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.42232
BRD-K25177502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53191
Pulmonary artery smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
intestine-407 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
GTEX-S3XE-0126-SM-4AD4R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829147
NCI-H2009	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55767
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22136
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517803
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCA433	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial outer membrane	GO Cellular Component Annotations 2025	1.0	null
mitochondrial respiratory chain complex assembly	GO Biological Process Annotations 2025	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.827724
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58211
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51841
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89475
Perturb_15980_KO_Tdrd6_SRP050899	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.27902
para-abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95133
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466032
Parabrachial nucleus, lateral division, ventral lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1573
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.98379
BRD-K23617623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27369
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
cyanelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.544411
TT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48794
L428	CCLE Cell Line Gene Expression Profiles	1.0	2.30235
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37459038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20423
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.9289
Pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.701
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16317
CDK10_knockdown_116_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.30101
rectum cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.817565
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-merged_Gene_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09189
HCV JFH-1_24Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.29596
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1808
CRCGN017_MCF10A.TP53.M_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34433
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.9952
TMEM199	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78634
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.670042
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30576
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.299
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3896
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
TRIP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0524
BRD-K42855618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1732
superficial stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24869
depression	GWASdb SNP-Phenotype Associations	1.0	0.486163
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.22657
Integral component of mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Cardiovascular Abnormalities	CTD Gene-Disease Associations	1.0	1.05648
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vacuole-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral part of alar m1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48726
GTEX-OHPL-1326-SM-3MJGG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25782
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12408
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37054
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052129
Meningococcal meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899334
Chloroplast stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.34
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.641858
FXYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03777
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956169
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.0706
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42251
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein targeting to mitochondrion	GO Biological Process Annotations 2015	1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.03046
HCC1195	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97785
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918015
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-OXRP-0926-SM-48TC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09478
Plastid thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
CEACAM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544926
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11806
BRD-K08205503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38521
septal nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42337
GRHL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07421
CRO-AP2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE154940_1_v_0_nbdy_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulate	GeneRIF Biological Term Annotations	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04233
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.704
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19571
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09666
CD37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497372
OPTN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500147
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374544
Brain Lower Grade Glioma_LGG_TCGA-FG-7637-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.07101
protein import into mitochondrial outer membrane	GO Biological Process Annotations 2015	1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85938
Extrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.42
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28074
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3364
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995835
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23343
Perturb_4582_OE_H3_SRP135904	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.52739
XRCC6	MSigDB Cancer Gene Co-expression Modules	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14822
phenothrin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46215
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.052326
CW-2	GDSC Cell Line Gene Expression Profiles	1.0	1.48095
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252637
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.69146
chr22_43955471_T_C_b38	GTEx eQTL 2025	1.0	1.00954
Ycf2/FtsHi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.741
BRD-K71472853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81042
Inflammation	CTD Gene-Disease Associations	1.0	1.72926
DNAJC11	Pathway Commons Protein-Protein Interactions	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99122228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18606
ChIP_NANOG_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.06203
mantle zone of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6994
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48967
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23627
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.35792
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838577
BRD-K39752756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16759
Outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.082
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.73795
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HuO9	GDSC Cell Line Gene Expression Profiles	-1.0	-2.30028
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543258
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06764
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
BRD-K31987278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26803
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.37014
JcP contribution to LTL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.64934
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.107
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051734
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.10732
PTPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467296
Parabrachial nucleus, lateral division, central lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02738
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.250708
BRD-K85912419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19968
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE209698_2_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23495
GSE213588_10_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
Reticulate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.478
NCIH2286_LUNG	CCLE Cell Line Proteomics	1.0	2.38859
UBE2G2	Hub Proteins Protein-Protein Interactions	1.0	null
Mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.103
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.11113
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04069
chloroplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.30766
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR6_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.46878
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.945988
KMH-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.4423
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73019
BRD-A02481876_Importazole_AGS_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869675
BRD-K72175798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21951
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RHOT2	Pathway Commons Protein-Protein Interactions	1.0	null
UQCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51462
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U2-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09773
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2917
CHD2	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06716
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899334
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ABC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52375
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18533
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE245270_2_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.407215
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
proctitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.612401
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851492
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O5-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00965
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93379
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.47348
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.14819
PHF8	ChEA Transcription Factor Targets	1.0	null
protein insertion into mitochondrial membrane	GO Biological Process Annotations 2023	1.0	null
BRD-K54351451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65266
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	1.0	4.90512
HeLa-229 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.118
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Etioplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.894
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.843655
Nausea	CTD Gene-Disease Associations	1.0	1.12703
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.989452
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71804
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pertussis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.3013
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07364
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	1.0	0.922049
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.078
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.968684
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18163
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A4EM-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DF-26-EY87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228706
CRCGN011_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07387
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07532
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KR-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP2CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07474
BRD-M86331534_BJM-ctd2-9_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
fluoxetine_mus musculus_gpl1261_gse35761	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897517
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27862
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25914
GSE119345_2_v_4_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
t69-brown-adipose_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-2.50602
Lung squamous cell carcinoma_LUSC_TCGA-66-2794-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.976022
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63403
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97102
abnormality of the biliary system	GWASdb SNP-Phenotype Associations	1.0	1.26441
BRD-K99633092_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882666
superficial stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47797
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferior frontal gyrus, opercular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.959212
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.46211
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bacterial-type flagellum filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.883
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05079
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nonalcoholic steatohepatitis-derived hepatocellular carcinoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.604576
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85703
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.8666
Medial preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83646
GTEX-XMK1-0926-SM-4B66X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913819
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00333
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A101D	GDSC Cell Line Gene Expression Profiles	1.0	2.09554
SNU-423	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.71513
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43794
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.24203
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
BRD-A68930007_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_83_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77003912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11654
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09054
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7418
CDK9_knockdown_104_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63439
HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.01474
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72858
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0316
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63043
fascia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377245
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.587
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.07125
BRD-K82754613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09707
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7949
alpha3-beta1 integrin-basigin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
GSE149903_0_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65095
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6886551__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Outer mitochondrial membrane protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Muscular Diseases	CTD Gene-Disease Associations	1.0	1.44111
E2F6	ENCODE Transcription Factor Targets	1.0	null
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
GSE201454_1_v_4_ftcd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04509
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
JEKO-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.78088
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.934
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.77353
MRK-nu-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.23607
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21807
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28799
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19096012-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989003
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.13584
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1915	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81372
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876651
PMC10079688-41467_2023_37633_MOESM7_ESM.xlsx-IP_JUN_after_pona_treatment-Supplementary_Data_4_List_of_interactors_of_JUN_identified_by_label-free_quantitative_proteomics_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0096
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.42396
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26233698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20387
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24836
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cytoplasmic exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
outer mitochondrial membrane organization	GO Biological Process Annotations 2025	1.0	null
PMC11310865-jcav15p5118s1.pdf-15-DMTF1_DMTF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19764
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	0.826853
Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sporulating cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
Mitochondrial creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.912
5054_MICAL3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635115
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01913
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.956095
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gut juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
central part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90519
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.65679
NCIH1092	CCLE Cell Line Gene CNV Profiles	-1.0	-2.47707
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28929
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PECAPJ41CLONED2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.21552
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE131798,GSE131804_5_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03445
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07418
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
occipito-temporal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899804
BRD-K76015448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00148
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68454
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
inner SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.828011
Sebaceous gland disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.034
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20795
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FIBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01693
SARS-BatSRBD_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.73376
Acute Myeloid Leukemia_LAML_TCGA-AB-2860-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17927
TMEM160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22411
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0105
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282788
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.9601
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01772
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06757
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.81327
PANC0504	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47997
preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01189
VDAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523911
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1563	CCLE Cell Line Gene Expression Profiles	1.0	1.38712
GSE111102,GSE111105_3_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1494
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63403
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.740515
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.71341
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55119
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06208
rectal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.6791
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100386_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.89603
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.900893
RMUGS	CCLE Cell Line Gene Expression Profiles	1.0	1.38811
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.92724
BRD-K15300571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26517
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	1.44051
lm9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11149
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11139
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859289
channel	GeneRIF Biological Term Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8518-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_90_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.69303
7645_SAMM50_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.874955
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36003376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00304
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8215
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
IRF4	ENCODE Transcription Factor Targets	1.0	null
Elaioplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.867
OV90	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64374
GSE229973_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plastid outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.88763
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Median preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16345
FCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34537
ChIP_NACC1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Fibrosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_AZ 960_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112161
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.3588
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0247
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43651
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00963
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0531
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CIAO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31107
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91470977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91762
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.97125
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.174425
Hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
POU5F1	ChEA Transcription Factor Targets	1.0	null
Organelle membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.134
GCIY	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.8362
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20515
hek293	HPA Cell Line Gene Expression Profiles	1.0	1.48479
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08522
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66792
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09293
Necrosis	CTD Gene-Disease Associations	1.0	1.83824
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2455
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.13647
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
layer 1 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18107
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.656
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
WHSC1	ENCODE Transcription Factor Targets	1.0	null
Gastrointestinal cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
STAT1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.50223
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08232
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.624781
outer SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.892695
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01148
chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.20705
FOSL1_KO_GSE43695_681_mouse_lung, bleomycin treated	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K19624190_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290649
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_11_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
Chloroplast inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.974
medial part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60663
coronary disease	GAD Gene-Disease Associations	1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC11542230-12985_2024_2548_MOESM4_ESM.xlsx-MR_results-exposure_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
SARS-CoV_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.61714
organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.58391
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18284
nuc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-2426-SM-3NB2V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.262
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.62041
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828936
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80103
BRD-K12749985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06174
Alcoholic hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
arterial stenosis	GWASdb SNP-Phenotype Associations	1.0	0.23832
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.446422
A4FUK	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84334
GTEX-S4Z8-0126-SM-4GICC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968885
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K36me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.066
TAT protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.761
outer membrane	GO Cellular Component Annotations 2015	1.0	null
cisplatin_homo sapiens_gpl6883_gse47980	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thylakoid lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.347
IGR-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.71167
Liver Diseases	CTD Gene-Disease Associations	1.0	1.38584
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92378241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13783
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00873
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.3355
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62276
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117563
TAL1	ENCODE Transcription Factor Targets	1.0	null
parvb	GeneRIF Biological Term Annotations	1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611334
Anemia	CTD Gene-Disease Associations	1.0	1.52161
Prospore membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.551
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A26S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03681
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
JiyoyeP-2003	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.75486
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47016
organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.0403
protein-containing complex assembly	GO Biological Process Annotations 2023	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.848
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.920482
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32093012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01409
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93395
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.476
Posterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78635
GTEX-XUYS-0226-SM-47JX1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914802
KDM5A	ChEA Transcription Factor Targets	1.0	null
single-organism intracellular transport	GO Biological Process Annotations 2015	1.0	null
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Elementary body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.466
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7886351-elife-65905-supp3.xlsx-Supplementary_file_3a-MYB_IP-MS_protein_lists_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
layer 6a of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11842
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.457208
SKMEL3	CCLE Cell Line Gene Expression Profiles	1.0	1.74371
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.94
BRD-K26543702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07192
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral septal nucleus, intermedio-intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14473
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cd4.Tcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.851335
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K24418561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33939
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64626
Perturb_16810_KD_Setd7_SRP075653	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.37925
NCIH1869	CCLE Cell Line Gene CNV Profiles	1.0	1.64077
Plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.342
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08231
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294256
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56892
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE166914_1_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ataxia	CTD Gene-Disease Associations	1.0	1.20558
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAKI1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14442
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2231
BRD-K76738405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05442
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07756
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5793
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
BRD-K69393995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27928
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054241
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Adult T-cell lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
azotemia	GWASdb SNP-Phenotype Associations	1.0	0.592047
BL-41 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.382
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8611
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0589
placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890965
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
HOXB4	ChEA Transcription Factor Targets	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.217693
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.544771
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44891
GTEX-W5WG-1126-SM-4LMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19976
ABC-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.23358
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27218
Fra-1_KO_GDS5078_403_mouse_Lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CDK8_knockdown_163_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.612563
Perturb_3212_KD_CNOT3_SRP117693	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39247
plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.2236
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
observed	GeneRIF Biological Term Annotations	1.0	null
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63401195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08321
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.049
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
melioidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.00921
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.90765
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02431
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.645
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29928
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55523
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93302
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.51084
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949171
toc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.32275
ELK1	ENCODE Transcription Factor Targets	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35036
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82987
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hematological and biochemical traits	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1699
SERINC1	Pathway Commons Protein-Protein Interactions	1.0	null
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505892
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985583
mitochondrial respiratory chain complex assembly	GO Biological Process Annotations 2023	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233651
fh8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
TARBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482782
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.03287
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RVH421	CCLE Cell Line Gene CNV Profiles	1.0	1.9923
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62137
Lung squamous cell carcinoma_LUSC_TCGA-60-2703-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40094
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
M14 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.36436
PPP1R12A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K08476323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23207
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27652
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18231
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HT-144	GDSC Cell Line Gene Expression Profiles	1.0	1.43138
CRCGN013_HEPG2_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88812
BRD-K99452971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00545
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
BRD-K45928581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5251
hsa-miR-122	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_96_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11893
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4608010-srep15184-s1.xls-uniqGenes_UP_DN_Targets-HAN_SATB1_TARGETS_DN_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
Endopeptidase Clp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.054
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28685
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2337
GABRA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645638
Cell pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.833
Dorsal part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08587
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A89434049_SARMENTOGENIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21191
Signal recognition particle, endoplasmic reticulum targeting	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
PMC11953091-12035_2025_4695_MOESM1_ESM.xlsx-s5-Supplementary_Table_5_Results_of_the_2-sample_pQTL_MR_on_insomnia_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GSE73628_8_v_2_igf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.62185
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3994
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lipid storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_103_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
subpallial septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64693
SOX2-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K43389675_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.906
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.862881
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44646
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC3189923-pone.0025991.s001.xlsx-CENPS-Unnamed_1_CENPS	Rummagene Transcription Factor Associations 2026	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901289
cSARS Bat SRBD_60Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.65981
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.745
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.135059
Body wall muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.837
EP300	ENCODE Transcription Factor Targets	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.95316
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00866
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHCHD3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GABP-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10801
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV4-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QXCU-0626-SM-2TC69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25545
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7429-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
impaired righting response	MGI Mouse Phenotype Associations 2023	1.0	null
ChIP_TCF3_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.769
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.91494
NR2C2	ENCODE Transcription Factor Targets	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36017
FOXP2	ENCODE Transcription Factor Targets	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.562974
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.748003
BRD-K95500860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46211
mitochondrial inner membrane	GO Cellular Component Annotations 2015	1.0	null
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825317
GTEX-XBED-1226-SM-4AT5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990512
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456335
Intracellular immature spore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.651
LNCAP	BioGPS Cell Line Gene Expression Profiles	1.0	0.910784
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.923803
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40148
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11488
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0826-SM-48TZO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989411
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.56239
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.900239
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
accumbens nucleus, shell domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07436
Apicoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
BRD-K35711197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2715
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.04449
conserved	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5687
GTEX-PW2O-0426-SM-48TCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864095
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.996283
tp92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
SPI1_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adult liver stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451042
BRD-K42799692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12043
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.915364
nucleus of the stria terminalis, medial division, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22448
GAK	GDSC Cell Line Gene Expression Profiles	1.0	2.61211
Prostate adenocarcinoma_PRAD_TCGA-CH-5752-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25499
Chloroplast outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.932
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU5F1-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86794
Lung adenocarcinoma_LUAD_TCGA-75-6212-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DHX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40273
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.970235
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Breast Cancer_Mammary Gland Tissue_GSE2429	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.45221
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.3679
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44857
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.923803
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33425
TCF3-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09261379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18196
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.2978
19061838-TableS4b	GeneSigDB Published Gene Signatures	1.0	null
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle outer membrane	GO Cellular Component Annotations 2015	1.0	null
Liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_140_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878858
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23478508_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periplasmic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.03729
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RAB20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51011
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.30421
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14901
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9127
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58417
Bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.705
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22536
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D7_W_B29__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hs-766T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.93646
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.58742
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22235
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28629
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16730910_regorafenib_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V7-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cristae formation	GO Biological Process Annotations 2023	1.0	null
GSE211931_0_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Chlorenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.04
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.958626
Uterine leiomyoma_Uterus_GSE2725	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.5288
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41016
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.04018
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240715
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358664
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.70062
NB5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.614
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63277230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11722
ChIP_POU5F1_18700969	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-0.854966
Mitochondrial intermembrane space protein transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.22
BRCA1	ENCODE Transcription Factor Targets	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53559
HSD17B4_KO_GDS3468_503_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54233
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
skin	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
mantle zone of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48726
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.440458
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5178-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.37162
BRD-K92241597_CHR 2797_THP1_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.12612
Chloroplast thylakoid membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
SSTR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00305353
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7023
K562_CEP-33779_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153276
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.349637
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07789
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tentacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
BRD-K04853698_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
BRD-K17893805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21609
ETS1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868056
BRD-A47109850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00484
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39391
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CL11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43916
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.79517
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47786
mitochondrial membrane organization	GO Biological Process Annotations 2023	1.0	null
BRD-K33606137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29288
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.367876
Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217101_0_v_1_mcph1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.995055
GTEX-OHPK-1326-SM-3MJGN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846153
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGFBR1_knockdown_102_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.99193
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.646291
BRD-K97540907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19178
BRD-K90962922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01933
BRD-K03489727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35687
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132948,GSE132949_4_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QS-1326-SM-3NMCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28228
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23327
Metabolic dysfunction-associated steatohepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70918
chr22_43979558_C_T_b38	GTEx eQTL 2025	1.0	1.46315
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.09541
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U937	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16288
BRD-A02799884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27408
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.915837
KRBOX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9727
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.652595
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.67775
BRD-K86773205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62661
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05796780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34301
SIX5	ENCODE Transcription Factor Targets	1.0	null
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.21352
NELFE	ENCODE Transcription Factor Targets	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45897
BRD-K11804865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34944
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.2384
Type III protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.46229
intermediate stratum of the PBC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18403
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37578
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
esophageal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.513802
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_154_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05184
skin	HPA Tissue Protein Expression Profiles	-1.0	-0.951019
GSE62843,GSE64370_0_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Fatty Liver, Alcoholic	CTD Gene-Disease Associations	1.0	1.57688
chloroplast part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.936905
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SPI1-20517297-HL60-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11157
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19238
BRD-K18409585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40687
18535662-TableS2d	GeneSigDB Published Gene Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.77136
Perturb_7226_KO_CDK8_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19534
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24151
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46309
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-150	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57101
IGR-1	GDSC Cell Line Gene Expression Profiles	1.0	2.0522
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26709
3-methylglutaconic aciduria type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SSTK	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.812731
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DYNC2I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21779
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Choanomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
sublayer 6a of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02314
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Type IV pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.53
vinpocetine-1557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68654
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.910195
GSE174735_2_v_0_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHCHD6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE239844_11_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	1.15998
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.349
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2249
TALL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mitochondrial transport	GO Biological Process Annotations 2015	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39018
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67364
SOX11	ChEA Transcription Factor Targets	1.0	null
evolutionarily	GeneRIF Biological Term Annotations	1.0	null
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05847
NFE2	ENCODE Transcription Factor Targets	1.0	null
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26269
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10613
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34449
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7413
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.64869
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-453 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.13896
Intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48292
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0434
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.277269
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300548
SUPT11	CCLE Cell Line Gene CNV Profiles	1.0	1.9704
ARID3A	ENCODE Transcription Factor Targets	1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26855
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.6575
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.8609
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	0.73974
GSE239844_11_v_12_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03816923_Rottlerin_A549_6.0_h_9.68_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EFNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613616
BRD-K83463455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08889
BRD-K70712801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40034
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.039761
BRD-K07348252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00385
Chromoplast envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12561
first (dorsal) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00357
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47423
PMC6886551__F4	PFOCR Pathway Figure Associations 2023	1.0	null
human immunodeficiency virus infectious disease	GWASdb SNP-Disease Associations	1.0	1.44051
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049686
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LB996-RCC	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41613
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.57415
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.708
Mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
KELLY	CCLE Cell Line Gene CNV Profiles	1.0	1.39324
BRD-A75409952_wortmannin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.91536
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.411
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.87715
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K52047843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68457
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54264
GSE252857_1_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
POLDIP3	Pathway Commons Protein-Protein Interactions	1.0	null
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04872
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10035
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00333757
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18896
SURF1	Pathway Commons Protein-Protein Interactions	1.0	null
ETS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00368383
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65377
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.683335
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60485
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
HMV-II	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.92407
SOCS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0086079
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.5816
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-1726-SM-4BOOD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919704
Medial geniculate complex, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90214
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20437312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27362
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67014046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36382
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.207912
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04872
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25161
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MSTO211H_PLEURA	CCLE Cell Line Proteomics	1.0	2.12069
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.54345
USF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81888673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20063
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136269
Perturb_6048_KD_PIAS2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.975007
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913056
SCC-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.05754
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936488
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.95022
spinal column	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.342602
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898114
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83863
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.14568
BRD-K43381631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34636
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cristae formation	GO Biological Process Annotations 2025	1.0	null
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91813
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70057
urinary bladder cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268137
UACC257	CCLE Cell Line Gene Expression Profiles	1.0	1.57911
BRD-K85722065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19734
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19595
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.5331
GSE226249_2_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22938
plague	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.412779
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.955616
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17461
anterior pretectal nucleus, dorsal superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64842
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70879
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.102
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35497
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.11911
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002594
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3887
Placenta	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.56258
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825317
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.520092
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65813
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S3-MECOM_up_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57958
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.869899
VMRC-RCW	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.80419
endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.821746
ovary	HPA Tissue Protein Expression Profiles	-1.0	-3.27432
chloroplast envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.20035
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0465
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24309
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.977304
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Hypercholesteremia_Hepatic Tissue_GSE3889	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.14545
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65440031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53011
BAK complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.177
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96048
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50587
BRD-K94469522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05072
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83289131_CAY10618_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IST-SL1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49833
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Heart_GSE9377_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.147
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.984471
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
establishment of protein localization to mitochondrion	GO Biological Process Annotations 2015	1.0	null
Nonalcoholic fatty liver disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.8
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.94965
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908453
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
b19	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
BRD-K99525048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03178
bacterial meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.891718
BRD-K34808207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32673
HOXC9	ChEA Transcription Factor Targets	1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08088
leukemia	GWASdb SNP-Phenotype Associations	1.0	1.26441
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bacterial microcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.596
GATA2	ENCODE Transcription Factor Targets	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994721
9962_ZBED2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.679537
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.883565
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.585
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876651
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44226
CHTOP	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K64770897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29929
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07897
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_H_sapiens_970_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of bone marrow cell morphology	GWASdb SNP-Phenotype Associations	1.0	0.314165
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2611
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
VSTM2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542345
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_13_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76210487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02634
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220645
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854256
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0145
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.83
Leucoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.597
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29728
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96356
pyramidal layer of taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26777
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.401
A-CA-04-2009(H1N1)_48Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.35732
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40609
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10406
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06189
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42795
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pioglitazone_rattus norvegicus_gpl341_gse21329	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849831
BRD-K38917645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27669
Metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34971
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.835415
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.03788
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28023
RFX5	ENCODE Transcription Factor Targets	1.0	null
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pregnancy Complications	CTD Gene-Disease Associations	1.0	1.21855
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1906
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65675
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
isoproterenol hydrochloride_rattus norvegicus_gpl1355_gse7999	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09144
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44243
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.711
SMC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0287
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.72266
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.842969
Outer membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.573
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-0126-SM-4JBH5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21922
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
translocon complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.30121
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZC3H12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77082
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962164
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR1I2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518776
sclc21h	HPA Cell Line Gene Expression Profiles	-1.0	-1.2364
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.19297
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MIS12/MIND type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.785
Hypertension	CTD Gene-Disease Associations	1.0	1.39338
HDLM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36911
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.890551
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14968
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
SKMEL1	CCLE Cell Line Gene Expression Profiles	1.0	1.82069
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9969
BRD-K77354492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11291
BA-56-QV45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203861
Prostate adenocarcinoma_PRAD_TCGA-VP-A876-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MIR140_Silencing_GDS3462_574_mouse_C3H10T1/2 fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K85525164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37607
HDAC2_Deficiency_GDS2624_658_mouse_Embryonic heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4959
Prostate adenocarcinoma_PRAD_TCGA-M7-A71Z-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Taenia tecta, ventral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28491
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mitochondrial sorting and assembly machinery complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	2.22994
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.923803
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.78893
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.86895
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
gemcitabine_homo sapiens_gpl96_gse6914	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR1I2	ChEA Transcription Factor Targets	1.0	null
esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.67113
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.861152
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.641001
BCAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056013
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cobalamin transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.235
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33002
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ehrlichiosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.506123
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLK1_knockdown_98_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.99022
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.908851
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bacterial surface antigen (D15)	InterPro Predicted Protein Domain Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I6-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43008
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52271
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13346
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.571
ZNF518B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50836
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.899
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.11965
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.895009
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5190-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08576
organelle part	GO Cellular Component Annotations 2015	1.0	null
15474998-tableS1c	GeneSigDB Published Gene Signatures	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
impaired righting response	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-R55G-2426-SM-2TC5I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855749
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.845058
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
Sporocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.78927
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883976
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03923461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26615
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.80101
commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.09308
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99125
BRD-K06203932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05012
Embryonic syncytium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Lung adenocarcinoma_LUAD_TCGA-MP-A4TK-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75164441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11305
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12001
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.969164
PTHrP_KD_GDS1664_438_human_MDA-MB-231	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.865
shape	GeneRIF Biological Term Annotations	1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86446
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.547002
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9588
Bone inflammation disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
voltagedependent	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0584
Lung adenocarcinoma_LUAD_TCGA-55-8614-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Succinate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.327
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.224808
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876651
MINOS1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-1126-SM-4DM71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8795
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner membrane complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.214366
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06839
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.61976
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8489
SAM complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GOLIM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533362
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cyanelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.867
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.61132
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_14_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9928
Primary somatosensory area, lower limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08735
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6445
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051429
BRD-K58715359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93244
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67023
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K64800655_PHA-793887_BT20_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.652449
r1 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45734
GTEX-XQ3S-1326-SM-4BOPQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00769
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43072
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.364734
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.91205
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06926
Dronabinol	CTD Gene-Chemical Interactions	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MMAC-SF	GDSC Cell Line Gene Expression Profiles	1.0	1.5162
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.93987
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
HDLM-2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.19564
GTEX-PWCY-0226-SM-48TD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30727
BRD-K51575138_TPCA-1_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6469
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.24401
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HS936T	CCLE Cell Line Gene Expression Profiles	1.0	2.5121
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.989
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19548
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K62979806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19524
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-Each_THP1_Pulldown_Expt_Targets-Unnamed_5_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43723
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5154
PHF8	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T5-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8657
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.409731
establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.19491
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.582
ChIP_NR0B1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-U66370498_BL-081_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.05387
Spinal nucleus of the trigeminal, oral part, caudal dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14996
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570022
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K42126874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4537
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882395
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16888
single-organism process	GO Biological Process Annotations 2015	1.0	null
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.20684
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ventromedial hypothalamic nucleus, dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41213
hsa-miR-3143	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
HuTu-80	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.08713
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	1.0	1.69256
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62625
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hepatic steatosis	GWASdb SNP-Phenotype Associations	1.0	1.67588
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
Sporozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.233
Neoplasms	CTD Gene-Disease Associations	1.0	1.17168
BRD-K92372829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11304
UHMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536865
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LY-01A-31R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26239
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.60756
Stromule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42974
BRD-A62809825_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plastid outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.938
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A-CA-04-2009(H1N1)_12Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.54771
Plastid intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.941
LMX1B_KO_GDS3320_57_mouse_embryonic (e11.5) proximal hindlimb bud tissues	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57306
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	1.54779
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12139
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
ghost	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212761
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XYKS-2426-SM-4AT43	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27636
BRD-K37850190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03148
DLG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48417
BRD-K40116023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03939
Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19163
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33404
envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.08628
mantle zone of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21629
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.61691
KDM5B	ChEA Transcription Factor Targets	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.912412
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.961619
hsa-miR-188-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K26443253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84256
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34741
HEC1A_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.22921
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903315
ETS1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	1.26441
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29138
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-7031-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05655
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organelle outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23968
hsa-miR-3622b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.34276
abnormality of immune serum protein physiology	GWASdb SNP-Phenotype Associations	1.0	1.02729
BRD-K88625236_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7958
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UR-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.59924
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Chloroplast outer membrane translocon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.181
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.885733
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08824
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein transmembrane transport	GO Biological Process Annotations 2015	1.0	null
colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.62885
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.545299
ChIP_POU5F1_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Tic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.949
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00838
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PA-80-RV09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214968
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_34_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
IRF3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77547920_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ecsit-NDUFAF1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27851
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228883
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
protozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.100348
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19548
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633372
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SALL4-18804426-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CDC7_knockdown_109_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.30844
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Taenia tecta, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19141
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05664
immune system disease	GWASdb SNP-Disease Associations	1.0	0.095235
MSH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29592
GTEX-SIU7-1826-SM-2XCE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89762
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22667
BRD-K12271646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33303
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885961
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394566
Myocardial Infarction	CTD Gene-Disease Associations	1.0	1.02522
496100404_PCx_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20789
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549744
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78742
GIMAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490506
Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78003637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15835
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16185
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3756
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93362
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58405
PMC10809641-DataSheet3.pdf-342-SALL1_SALL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68676343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22832
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048148
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.519
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.937
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07231
mitochondrial membrane organization	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01023
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7008
Organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.59
CEBPB-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K56188606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35806
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
b12	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.075986
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1092	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52606
GSE176305_0_v_3_rotenone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERG	ChEA Transcription Factor Targets	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.80733
MRPS11	Pathway Commons Protein-Protein Interactions	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.17366
BRD-K52075209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.423
D-336MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60926
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	1.8572
E2F4	ENCODE Transcription Factor Targets	1.0	null
abnormal tooth morphology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Organelle biogenesis and maintenance	Reactome Pathways 2024	1.0	null
STPG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65831
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARA_KO_GDS3748_516_mouse_Livers	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07363
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50484
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0926-SM-4BRVQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899171
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.44312
metaxins	GeneRIF Biological Term Annotations	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958932
Inferior salivatory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42692
JHOS-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.64118
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Granum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.146
POU5F1-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.74017
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34183
ABC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.23712
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.2287
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.11344
Mitochondrial iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.876
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851741
mitochondrial transport	GO Biological Process Annotations 2025	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80576
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01447
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061296
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45669
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34553
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80891
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB3A_Mutation - D77G point mutation_GDS2482_702_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.6084
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.77911
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30187
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A65R-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.33848
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
r2 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59187
rough endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.766804
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.2255
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5099-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.20765
Primary somatosensory area, upper limb, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5384
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
JHOM2B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4319
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K20me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40605
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155369
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.62642
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898859
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137693
BRD-K73769678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01149
Acne	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.034
BRD-K68065987_MK-2206_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77238
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55109
BRD-K77207661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67984
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971159
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
SPECC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A02481876_Importazole_HEC108_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE149075_8_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MELHO	CCLE Cell Line Gene CNV Profiles	1.0	2.71862
MRPL11	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KCNQ4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631016
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.88127
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of lipid metabolism	GWASdb SNP-Phenotype Associations	1.0	0.314165
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28113
DMS114	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
NR2F2	ENCODE Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83775
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21806131_tegaserod_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21672174_Ro 28-1675 ?_A549_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
KBTBD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539345
BE-04-AN21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333072
mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.935461
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alcoholic liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.655
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mental depression	GWASdb SNP-Disease Associations	1.0	0.570595
BRD-K12750296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16652
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Protozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.624
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27372
suz12_17339329_mouse_embryonic_stem_cell_es_cell_lof_mouse_gpl1261_gse31354	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.046052
GTEX-S4Q7-0726-SM-4AD5F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85293
Alanine aminotransferase levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
Pod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49842
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08785
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3535
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09361
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.34518
H3K9ac_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14272
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
BRD-K79264000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06264
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.968048
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sam50	GeneRIF Biological Term Annotations	1.0	null
CHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42577
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Melioidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.132
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09184
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.5186
cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K56261053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18191
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839767
erythrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.167949
Meningitis	DisGeNET Gene-Disease Associations	1.0	null
DA-69-UN88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200868
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53898
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80237
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983797
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913758
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40476324_Digoxin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR0B1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
Chloroplast intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.895
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SL-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39797
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10995
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94Y-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.27363
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.89815
striatal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70232
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62959606_EI-155_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mantle zone of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61975
biogenesis	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.055
BRD-A02481876_Importazole_A549_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15978
VDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24279
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.20427
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
PTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94165
Trypanosomoid form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.06
Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lysosomal storage disease	GWASdb SNP-Disease Associations	1.0	0.855495
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NHLRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19401
dactinomycin_mus musculus_gpl6246_gse21233	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59247
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	1.0	2.386
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.33239
septostriatal transition area (accumbens)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21629
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00864698
TMEM39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16184
Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894812
Measles Chicago-1_24Hour_16492729_GSE980	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.0575
KLF4	ChEA Transcription Factor Targets	1.0	null
outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	2.11002
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.863468
BRD-K31678817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40762
BRD-K38604123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44137
SAOS2	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.59932
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Primary somatosensory area, lower limb, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56787
BRD-K19457629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21098
r7 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1518
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.071
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecule localization	GO Biological Process Annotations 2015	1.0	null
r4 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01476
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Integral component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
G361	CCLE Cell Line Gene Expression Profiles	1.0	1.95129
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CG-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.752996
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588645
protein localization to membrane	GO Biological Process Annotations 2015	1.0	null
MIST1_KO_GDS1731_758_mouse_Pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-XUJ4-1226-SM-4BOPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87618
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.349349
Mitochondrial inner boundary membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.999
HEC251	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72437
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M4-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Periventricular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.59124
MYC_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular protein transport	GO Biological Process Annotations 2015	1.0	null
GTEX-QVJO-0526-SM-447CE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98654
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71266
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.51286
imatinib_homo sapiens_gpl571_gds3518	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K28937085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09593
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
Mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.94
GTEX-S4Q7-1126-SM-4AD6R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955075
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71842353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54398
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.89
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.538001
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.871123
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
periventricular stratum of r7Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27145
BRD-K81246784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25189
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K57443386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0475
BRD-K06218527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3032
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K86102179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60778
NCI-H2009	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.10271
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.43515
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.226
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.576
TROVE2	Hub Proteins Protein-Protein Interactions	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47408
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
esophagus adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.415024
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.63125
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20414
Lateral terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1308
STAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11974
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.609
MEOX2	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992017
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.55912
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73115
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.41063
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1997
IGROV-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1914
H3K9me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of purine metabolism	GWASdb SNP-Phenotype Associations	1.0	1.26441
Microsporidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.439
Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
gastroesophageal junction	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.535833
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-0126-SM-4LVMH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16633
Spear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
BRD-K02118124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67244
Primary somatosensory area, upper limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37994
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61804
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.833549
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.973013
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07081
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.49758
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.726
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.1272
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.87079
MAP2K6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720944
BRD-K84595254_Strophanthidin_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.69842
BRD-K69355244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31594
NHERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28592
BRD-K06492501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02487
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.18683
nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.036744
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2716
lateral IC periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02669
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.74309
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40653
SUP-HD1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.67371
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915222
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.11493
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-1226-SM-48TCO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835942
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20868
fatty liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.520731
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.21402
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4541
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
BRD-K20160406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29422
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.36667
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.047128
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.924463
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34137
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.38821
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.625319
FAM47E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35849
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
HS578T	CCLE Cell Line Gene CNV Profiles	1.0	1.42009
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5838-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20724649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00492
A549_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014098
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82635
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43913
periventricular stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95546
lymphoma	GWASdb SNP-Phenotype Associations	1.0	1.26441
SLC25A17	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988778
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10588
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384907
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6847-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
b18	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
GSE128730_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09265
intermediate stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0288
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03364
four	GeneRIF Biological Term Annotations	1.0	null
SARS-dORF6_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52668
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.966696
Lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
TE9	CCLE Cell Line Gene Expression Profiles	1.0	1.38872
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597289
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4477
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19697
SIGLEC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505726
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62383
BRD-K15992638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84751
protein complex	GO Cellular Component Annotations 2015	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.662
BRD-K11269634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20831
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.463735
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.19345
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10611
BRD-K16689648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2791
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219958
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46224
type iv pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.316708
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.156978
OCI-AML2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
r5 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04204
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01685
organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932191
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15701
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.05586
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36635
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061277
camptodactyly-arthropathy-coxa vara-pericarditis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23709
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27226
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15757
Anterior cingulate area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01424
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.761
BRD-K15285842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67327
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mating projection tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.602
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.528
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69815
BRD-K09473191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26402
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63273
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42918
AC-28-RT00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383276
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.75496
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02049
PITPNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08249
r6 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50366
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POPDC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572727
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.863362
BRD-K39179354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26611
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836862
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRN-0526-SM-2I5EN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31578
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pnpla3	GeneRIF Biological Term Annotations	1.0	null
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
monocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.303059
BRD-K97485956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56925
RCOR3	ChEA Transcription Factor Targets	1.0	null
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13659
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHUK_knockdown_108_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.90852
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53442
Metabolism of proteins	Reactome Pathways 2014	1.0	null
IHH-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.1747
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.91305
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Flight muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
Lung squamous cell carcinoma_LUSC_TCGA-18-3411-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
C32	CCLE Cell Line Gene CNV Profiles	1.0	1.43147
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441811
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0734
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35061
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.637578
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13124
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926686
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.853917
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910265
NCIH1092	CCLE Cell Line Gene Expression Profiles	-1.0	-2.79857
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4183
SAP30	ENCODE Transcription Factor Targets	1.0	null
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.81473
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2073	CCLE Cell Line Gene CNV Profiles	1.0	1.70771
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0762
M14	BioGPS Cell Line Gene Expression Profiles	1.0	0.915538
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
chchd3	GeneRIF Biological Term Annotations	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825317
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28396
DD-89-HG56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.776745
BRD-K93484038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27573
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878902
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.63795
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE220942_2_v_1_galnt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.55385
SUZ12	ENCODE Transcription Factor Targets	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50445
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.84942
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Caov-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.3812
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Uniplex complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06492
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.546
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55069
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858761
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00319
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.772275
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Total cholesterol levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.628457
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38406
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	1.75387
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95728
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.653
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12422
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34902
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.963921
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46358
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
been	GeneRIF Biological Term Annotations	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ7-mel	GDSC Cell Line Gene Expression Profiles	1.0	1.56576
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26272
RPL23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64294
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15346
Intrinsic component of cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.901
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.757
increased blood urea nitrogen (bun)	GWASdb SNP-Phenotype Associations	1.0	1.26441
Cholesterol, total	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17361
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825317
Trophozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
496100389_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50184
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09819684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12136
MYOG	ENCODE Transcription Factor Targets	1.0	null
BRD-K19418944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03789
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8085
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.665307
SP2	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26675
PML	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4924
plastid part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.866287
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
Cancer of Colon_Intestine - Large Intestine - Colon (MMHCC)_GSE4107	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.36015
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05107
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03798
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41202439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02109
TRIM28	ENCODE Transcription Factor Targets	1.0	null
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.19494
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.89989
DGAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691881
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.626851
vitamin e_mus musculus_gpl1261_gse42813	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.006
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.07751
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25801
Mycolate outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.551443
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92133
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.882002
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946004
Plant parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A2QQ-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03372
SAM complex	GO Cellular Component Annotations 2025	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2856-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SKMEL30	CCLE Cell Line Gene Expression Profiles	1.0	1.43096
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45181
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04263
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dyslipidemias	CTD Gene-Disease Associations	1.0	1.06479
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21123
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.838998
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2099
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.865294
Breast Cancer_Mammary Gland Tissue_GSE1872	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.54054
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.641
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09125
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.0827
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20222
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10521
urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121738
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28478
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20861
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7221-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H1703	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12848
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35257
19306436-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.01865
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.181613
YPEL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07646
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.70992
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88128293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06678
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22346
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.24684
PFKP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00725251
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34012
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chloroplast ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.548
SALL4-18804426_ESC-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03951
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827496
H2AC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47616
mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.515716
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47W-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K39516553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19183
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lateral septal nucleus, rostral (rostroventral) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97923
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26102
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57957
BRD-K42697646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23797
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33009
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08544
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
protein import	GO Biological Process Annotations 2015	1.0	null
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.337751
Gout	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88403
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61265
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
16728581-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.46701
Translation initiation ternary complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.537
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VCAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00695505
BRD-K32582260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14337
morphology	GeneRIF Biological Term Annotations	1.0	null
CRCGN009_HEPG2_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29286
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S11-Table_S11_MR_resluts_of_brain_pQTL_and_any_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE252857_1_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2949-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36557
Sengers syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
APOBEC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30235
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.151
GATA2	ChEA Transcription Factor Targets	1.0	null
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.22207
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40802
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.03328
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.071
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76079
paclitaxel_homo sapiens_gpl570_gse39042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39413
BRD-K16681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07667
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.979695
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CD74	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619889
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
Liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.716
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386356
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.711797
Lung squamous cell carcinoma_LUSC_TCGA-77-7463-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883101
BRD-A52650764_Ingenol 3, 20-dibenzoate_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F4-06A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO741	CCLE Cell Line Gene Expression Profiles	1.0	2.08682
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139966_5_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41517
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31363
GTEX-RWSA-1126-SM-2XCAZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25131
BRD-K91779437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52608
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02089
BRD-K74680333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11362
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8041-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6872
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.34388
BRD-K23442578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17581
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14272
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, upper limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24087
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05767
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961071
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.729002
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hydrogenosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.383
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12644
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.766804
sevoflurane_homo sapiens_gpl570_gds2772	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98817
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901654
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299918
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13266
NR0B1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30546
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200320_1_v_0_mfge8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88981
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein transport	GO Biological Process Annotations 2015	1.0	null
BRD-K65432867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51551
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.444
abnormality of bone mineral density	GWASdb SNP-Phenotype Associations	1.0	1.26441
SLC1A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00399207
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6075
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10181
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336472
MTX1	Pathway Commons Protein-Protein Interactions	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20645
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36171309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91883
PMC9020200__F3	PFOCR Pathway Figure Associations 2024	1.0	null
mitochondrial transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Polytene chromosome chromocenter	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.529
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10481
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4711-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
12907009-SuppTable	GeneSigDB Published Gene Signatures	1.0	null
MDAMB435S	CCLE Cell Line Gene Expression Profiles	1.0	1.7277
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20181
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0926-SM-3NB2Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902935
membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K05096562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35039
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21122
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.091312
MYC	ENCODE Transcription Factor Targets	1.0	null
MVD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34471
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09053
NCIH1915	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57737
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921066
HSPD1	Hub Proteins Protein-Protein Interactions	1.0	null
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04509
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.14392
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MEL-JUSO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79334072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01195
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10917
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
16597596-TableS2-4	GeneSigDB Published Gene Signatures	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888377
Lateral septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.22042
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
er-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.759978
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV2-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26570871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47453
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47150025_Ki 8751_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.0068
COASY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11307
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06496
CEBPB	ENCODE Transcription Factor Targets	1.0	null
H3K9me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67566344_KU-0063794_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7327
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.991469
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.144234
WF-85-JN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256717
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8545
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93325
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A491-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84095
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02199
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
S-layer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.403
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09838
least	GeneRIF Biological Term Annotations	1.0	null
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.11877
mitofilin	GeneRIF Biological Term Annotations	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.833675
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69201
Twig	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.663
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.42062
outer SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.900752
Leukemia_promyelocytic-HL-60	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.21237
single-organism transport	GO Biological Process Annotations 2015	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25813
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.82711
T3M10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35599
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10465
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44652
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5795
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A185-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2708-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12552
Curli	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
Procyclic form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64986
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.71464
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01823
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFO21	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57427
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
vesicle	GO Cellular Component Annotations 2015	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44376
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.01393
ONS-76	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19633847_PERHEXILINE MALEATE_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27532
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912432
HslUV protease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BCL7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35983
BRD-K09777330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76096
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.75322
NACC1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism membrane organization	GO Biological Process Annotations 2015	1.0	null
abnormality of cells of the erythroid lineage	GWASdb SNP-Phenotype Associations	1.0	0.353621
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLT4_knockdown_103_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.97185
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MIB complex	GO Cellular Component Annotations 2025	1.0	null
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0616
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244865
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04853
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Reactome Pathways 2024	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69391
mitochondrial sorting and assembly machinery complex	GO Cellular Component Annotations 2015	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10525
abnormality of erythrocytes	GWASdb SNP-Phenotype Associations	1.0	0.353621
BRD-K18621941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02831
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15774
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28163
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102783
Flagellate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
mcf7	HPA Cell Line Gene Expression Profiles	1.0	0.829783
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22975
BRD-K74789550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.406
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71A-01A-22R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04923
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941911
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840525
TMOD3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-1238	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Chloroplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.348
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SPSB1	Hub Proteins Protein-Protein Interactions	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.922013
GTEX-OOBJ-1526-SM-3NB1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14493
CEBPD	ENCODE Transcription Factor Targets	1.0	null
Mitochondrial outer membrane translocase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33744
vascular disease	GWASdb SNP-Disease Associations	1.0	0.196125
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54141134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.132
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901145
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_6_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.93969
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6782
Integumentary system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.034
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43997
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
BRD-K34739404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5168
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_335_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Arthritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.978603
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RLBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565598
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56176
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1738
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
H3K56ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.732
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16283
NCIH1395	CCLE Cell Line Gene Expression Profiles	1.0	1.45862
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1897	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51881
FGFR3_knockdown_174_GSE41035	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.64734
liver enzymes	GAD Gene-Disease Associations	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20695
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.493
dexamethasone_mus musculus_gpl339_gds2314	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927553
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.801455
efo21	HPA Cell Line Gene Expression Profiles	-1.0	-0.910245
Mitochondrion	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
outer SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.897954
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.890921
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.2206
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.833664
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0716
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.11116
RUNX1	ChEA Transcription Factor Targets	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2663
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63045
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43117
K029AX	CCLE Cell Line Gene Expression Profiles	1.0	1.37821
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32049721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.762
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05521
Intrinsic component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A19633847_PERHEXILINE MALEATE_JHUEM2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GOT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485525
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biofilm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.607319
tom	GeneRIF Biological Term Annotations	1.0	null
PMC3189923-pone.0025991.s001.xlsx-CENPB-Unnamed_1_CENPB	Rummagene Transcription Factor Associations 2026	1.0	null
MIB complex	GO Cellular Component Annotations 2023	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.34694
GSE137914_4_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4975-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fallopian tube disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
9454_TXNIP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.673377
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33239
dorsal peduncular cortex, periventricular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1904
GSE138024_2_v_3_rgs4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.42466
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946274
medial parabrachial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18622
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular protein transport	GO Biological Process Annotations 2025	1.0	null
HIF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79517
Pain	CTD Gene-Disease Associations	1.0	1.1556
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.632
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-1.11113
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3768
BRD-A60245366_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ranolazine_mus musculus_gpl1261_gse25767	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.504
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S15-Table_S15_MR_resluts_of_brain_pQTL_and_small-vessel_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Bloodstream form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.161
Invertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
FLI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599875
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0226-SM-4B65D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978201
BRD-K04853698_-666_SNU1040_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43663
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Serum Total Cholesterol Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35291
BRD-K64800655_PHA-793887_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06145
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.623335
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37436
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.53435
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paraseptal subpallium	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27577
BRD-K36940835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.726
Hyperplasia	CTD Gene-Disease Associations	1.0	1.3314
17724462-TableS2	GeneSigDB Published Gene Signatures	1.0	null
helps	GeneRIF Biological Term Annotations	1.0	null
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02582
GSE150634_1_v_0_cd28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A52650764_Ingenol 3, 20-dibenzoate_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900835
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.873643
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09657
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.693
CAKI-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49954
CSNK1E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045098
internal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26085
ALPP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18889
SARS-dORF6_96Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.35557
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INF2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8804
lymph	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
pertussis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.251718
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53831
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94578
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15288
mantle zone of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4324
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3-methylglutaconic aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
TCF3	ChEA Transcription Factor Targets	1.0	null
Periplasmic side of cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.901
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66454
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
GTEX-P4PQ-1626-SM-2HMKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62457
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
BRD-K07281036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18103
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TIA1_KO_GSE54418_261_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
T3M4	CCLE Cell Line Gene CNV Profiles	1.0	1.79475
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044027
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873466
rectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	2.22355
Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27343
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Leaf bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2308
BRD-K12011077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78968
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.36987
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S23_LF_C1_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0426-SM-3NM99	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19098
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease by infectious agent	GWASdb SNP-Disease Associations	1.0	0.233058
PHLDA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33094
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0916
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25184
BRD-A69383366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62363
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T/G HA-VSMC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r3 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34652
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19667
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lysosomal storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.068
hsa-miR-644	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HDLM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68139
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QC-A6FX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAM complex, Tim23 associated import motor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.65
PPP6R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28304
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04255
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71732
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36593
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
Mandibuloacral dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
GSE252988_0_v_1_lefamulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitochondrial outer membrane translocase complex	GO Cellular Component Annotations 2025	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987541
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07771
CREB1	ChEA Transcription Factor Targets	1.0	null
A-CA-04-2009(H1N1)_48Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.3517
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2592
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.09175
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051146
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17113
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047974
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.988219
EFTUD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40885
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40394
BHT101	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59579
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESRRB-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7509
septopallidal shell area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1303
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.747481
Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45011
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Photosystem II oxygen evolving complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.913
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47437
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7767
GTEX-XXEK-0726-SM-4BRWF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994942
BRD-K28165728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12812
Viral hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
GATA2-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
Anterior hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06852
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28525
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33444
daudi	HPA Cell Line Gene Expression Profiles	1.0	0.843481
Nucleus of the brachium of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61326
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.728
PRRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36159
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4593
ALPPL2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921616
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831695
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3863
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63809385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05492
KATNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41761
DSH1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.333
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.91066
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.909945
Trypanosomoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.993
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3504