association	dataset	threshold value	standardized value
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.22327
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41175
MYCN-19997598-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K43628610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22083
COL26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51903
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843283
COL7A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50099
ICAM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83792
r2 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31396
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-1.2418
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53494
ZNF273	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71292
SYDE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02221
TCEA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37284
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC0203	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63404
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02201
hsa-miR-3677-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.352
Wolff-Parkinson-White syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.61171
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13241788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14247
Longitudinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0709
FASTKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64273
SCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5748
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25589
RUNX3	ENCODE Transcription Factor Targets	1.0	null
BRD-K94790210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06666
RH-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.72358
DDX3X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86359
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LRRC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03151
TAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80961
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1719
focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.66755
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25236
Mat-Ly-Lu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of monoatomic ion transport	GO Biological Process Annotations 2025	1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42391
BRD-A67787745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80232
cleavage	GeneRIF Biological Term Annotations	1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
BRD-K17232330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73831
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r2 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08512
BRD-K01676126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25865
STC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49283
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882215
PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
LN319	DepMap CRISPR Gene Dependency	1.0	2.17881
BRD-K82249895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9802
BRD-K73394628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38721
hsa-miR-622	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
XPO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06451
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.15797
BRD-K41714444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28428
hsa-miR-519c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42543
HPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13422
sodium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2769
TIFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24654
SEPTIN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31886
PROCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16111
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850321
TRNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1317
PANC0504	CCLE Cell Line Gene Expression Profiles	-1.0	-3.01373
BRD-K12306640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0953
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6017-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61310138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78595
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948108
Lung squamous cell carcinoma_LUSC_TCGA-22-5472-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEL	CCLE Cell Line Gene CNV Profiles	1.0	1.83935
Perturb_2261_KO_Mbnl1_SRP014709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.19752
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088036
bc89	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.135
regulation of sodium ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
ANGEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56338
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.0396
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20514
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07148
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08835
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
SH3BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59085
KLF4-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-3127-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSD17B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56283
PHF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96225
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16645
hsa-miR-4261	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
Early infantile epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
Receptacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
COPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8171
hsa-miR-4516	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8123
regulation of atrial cardiac muscle cell membrane depolarization	GO Biological Process Annotations 2015	1.0	null
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77P-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19159562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83168
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.691246
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.2132
Long QT syndrome 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
CCDC88A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12735
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
membrane depolarization during cardiac muscle cell action potential	GO Biological Process Annotations 2015	1.0	null
PATU8902	DepMap CRISPR Gene Dependency	1.0	3.60745
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.986799
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PNPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94019
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.166
metal ion transport	GO Biological Process Annotations 2015	1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34315
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.868376
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83555
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.991
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25206
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843283
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12693
r4 part of descending trigeminal sensory nucleus, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61035
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.11686
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899064
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ERVK3-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50502
Giant axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.185
AGFG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37219
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17948
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80889
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.2242
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58002
cation channel complex	GO Cellular Component Annotations 2015	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.452152
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166308_1_v_0_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941513
PTPRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54573
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186065_0_v_1_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25457
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Neurological pain disorder_Dorsal Root Ganglia_GSE15041	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.79664
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868996
PMC2820592-NIHMS144142-supplement-8.xls-LMS_SAM_1-GENES_HIGHLY_EXPRESSED_IN_GROUP_I_muscle-enriched_LMS_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
anterograde trans-synaptic signaling	GO Biological Process Annotations 2023	1.0	null
PPP1R3E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84351
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829617
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90764
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53682
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2554
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.069795
Perturb_4527_OE_Hk2/Pkm_SRP052789	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.51469
BRD-K05804651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04719
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.2418
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0007
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CACNA2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36247
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98067
KLHDC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55611
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38407
DU4475	DepMap CRISPR Gene Dependency	1.0	4.23324
SLC16A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16747
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
furazolidone-4098	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Familial atrial fibrillation	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54331
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.941804
BRD-K97106314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05626
INPPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6858
FAM181B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24489
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WDR76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56202
Sarcoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.565
hsa-miR-3140-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
mantle zone of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08678
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3425
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2BC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89201
SCN1B	Pathway Commons Protein-Protein Interactions	1.0	null
TDGF1P3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28345
decamethrin	CTD Gene-Chemical Interactions	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.63006
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5691-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.56779
TRIP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84277
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
hsa-miR-17	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28884
IPC298	DepMap CRISPR Gene Dependency	1.0	2.31223
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40448
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A8O0-01A-41R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06928
ATP1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96586
ion transport	GO Biological Process Annotations 2015	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Prostate adenocarcinoma_PRAD_TCGA-EJ-7331-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
NXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39718
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3614
JUP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68334
BRD-K78207246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23726
Perturb_943_KO_Sftpa1_SRP246320	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.5011
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77652
BRD-K32723442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12257
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03675
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	1.05775
BRD-K13289658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07416
pallidal islands of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12859
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	1.2092
BRD-A06578049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.519
ABHD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40333
PMC11015551-12915_2024_1879_MOESM8_ESM.xlsx-depmap_predictability_data_REST-feature_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0352
GTEX-S4Z8-0926-SM-4AD6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902366
ventromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18518
syndrome	GeneRIF Biological Term Annotations	1.0	null
SMIM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12479
Developmental Biology	Reactome Pathways 2024	1.0	null
NBEAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7913
Perturb_5825_KO_Pax5_SRP185455	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.0568
MYC	ENCODE Transcription Factor Targets	1.0	null
BRD-K64753899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07607
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33178
Heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.661
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03507
BRD-K62555617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5677
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00119817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30421
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.828035
TRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49006
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38535
BRD-K35788497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18836
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7192
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE264621_1_v_3_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055257
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824603
Lung squamous cell carcinoma_LUSC_TCGA-18-3409-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.277
hsa-miR-4428	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.92831
RPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32931
PMC5575985-mp2016192x3.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28643
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58583
sodium channel complex	GO Cellular Component Annotations 2015	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
abnormality of cells of the erythroid lineage	GWASdb SNP-Phenotype Associations	1.0	0.319931
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49545
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LTBR_INHIBITION - 1 Day_GDS2005_728_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YW-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32275
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03619
BRD-K14961381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54331
NCI-H650	GDSC Cell Line Gene Expression Profiles	1.0	1.64678
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996988
TCF3-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73075421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.516
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.2418
RNA helicase p68_KD_GDS2152_626_mouse_skeletal muscle cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02012
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3687
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.995307
nicotine_myzus persicae_gpl9470_gse18658	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08802
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-U02532950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07914
UQCRHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57763
PDZD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19298
aclarubicin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63748
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10163
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
regulation of membrane depolarization	GO Biological Process Annotations 2025	1.0	null
L428	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85824
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250953
VPS26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44943
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.71711
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99371
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72884
voltage-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224645
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4202
hsa-miR-636	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060043
periventricular stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03993
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10377
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54326
BRD-A82843133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23292
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1579
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60658
BRD-K78009480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.444
BRD-A76904477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05041
Uvula (IX)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03529
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42062
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.681
fludroxycortide-6039	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE196540,GSE196542_2_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8551_KD_Tet3_SRP056501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958174
BRD-K14499901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92051
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14363
Cerebellar nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
heart contraction	GO Biological Process Annotations 2023	1.0	null
PLD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16858
GTEX-XOT4-0008-SM-4B664	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08503
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.943849
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50784
hsa-miR-670	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28721
BRD-K50190949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87359
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31472
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67751
CCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16061
TSTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5661
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.861237
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRCA1_DEPLETION_GDS3791_502_human_Hela cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900767
TAF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
membrane depolarization during cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
piccolo-bassoon transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18562847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46562
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5013636-ncomms12601-s5.xlsx-TCF3-Groups_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
ABCB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90157
spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.309697
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055327
POMC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35844
PHLDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41594
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SLC25A28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36692
posterior (ventral) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54314
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2229
Hypokalemic periodic paralysis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
THUMPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15321
C11orf86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45681
Brugada syndrome	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
TGOLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.63962
BRD-K69274755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51949
SMIM10L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83186
GTEX-RNOR-0008-SM-48FEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990101
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19D-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
telmisartan_rattus norvegicus_gpl4135_gse29445	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
SP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07916
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88014
18332912-Table2	GeneSigDB Published Gene Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QV-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FKBP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82367
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.13402
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57004
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948108
hsa-miR-369-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.131849
muscle contraction	GO Biological Process Annotations 2015	1.0	null
CLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.1645
hsa-miR-519a	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.21112
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
MAPK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61472
USF2	ENCODE Transcription Factor Targets	1.0	null
ADRA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17322
Idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.188
SAAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29836
membrane depolarization during action potential	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3120-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07056
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18308
peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.225917
Costamere	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885388
Cardiac arrest	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.875
PAFAH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79393
CERS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2097
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.672024
Lobules IV-V, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.192
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41695
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36408
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.946969
UCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27677
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51231
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151829,GSE151831_7_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BUB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62777
Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01881
BRD-K84246050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04183
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13014
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.902649
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16118
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6937
Perturb_1612_KO_Sidt1/Sidt2_SRP335374	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.65962
CBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55192
PRKCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73376
TMEM74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7395
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33099
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GTEX-REY6-1726-SM-48FDL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ZDHHC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9615
intermediate stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81869
Variant of unknown significance	ClinVar Gene-Phenotype Associations 2025	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96777
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
RNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71105
PIN1_DEPLETION_GDS4070_450_human_MDA-MB-231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
STK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46622
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38084509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86519
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6171
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09352
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.092
ARFGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9055
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YAP_OE_GDS3220_32_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-A43135847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06537
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
XPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09316
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055927
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC12A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6073
HOS	COSMIC Cell Line Gene CNV Profiles	1.0	2.14116
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NDUFB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26284
XRCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60602
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PRPS1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39904
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11480_OE_Nrtn_SRP328708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.52438
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
LS513	CCLE Cell Line Gene Expression Profiles	1.0	1.37326
Kir2 inward rectifier potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
abnormality of the eye	GWASdb SNP-Phenotype Associations	1.0	0.120689
BRD-K09777330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00186
CEP170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99639
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
Trigeminal nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.8999
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3236
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4694
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47343
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
heart contraction	GO Biological Process Annotations 2025	1.0	null
RIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64541
response to insecticide	GO Biological Process Annotations 2015	1.0	null
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6165
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FB-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05634
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66351990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21128
SNU886	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73552
NRBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36633
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34875
MALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17024
Middle cervical ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843283
HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68751
BRD-K92202681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36025
GSE196540,GSE196542_4_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K20846358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10907
Lung adenocarcinoma_LUAD_TCGA-44-2655-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4690-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
Muscle contraction	Reactome Pathways 2024	1.0	null
chemical synaptic transmission	GO Biological Process Annotations 2025	1.0	null
TRIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17568
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
ZNF281	ChEA Transcription Factor Targets	1.0	null
ALG12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87004
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58842
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24092
GTEx Brain 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-16.2243
BRD-A12372458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63919
Congestive heart failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.746
KMS12BM	CCLE Cell Line Gene Expression Profiles	1.0	1.36432
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37652
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.978
RAPA_EARLY_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
sodium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850196
BRD-K52372795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4631
membrane depolarization	GO Biological Process Annotations 2015	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNASE2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70778
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76261
NNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5015
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
flutamide-2358	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Osteoarthritis_Synovial Membrane_GSE1919	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.53232
hsa-miR-4535	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ISL1-27105846-CHIP-SEQ-CPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCIH1651	CCLE Cell Line Gene CNV Profiles	1.0	1.51765
hsa-miR-4329	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08366
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PCGF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90308
Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paramyotonia congenita of Von Eulenburg	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
A-VN-1203-2004(H5N1)_Day2-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.97548
GTEX-PWN1-0626-SM-48TDT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937533
Parallel fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.316
PPP2R5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06543
ZER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41512
hsa-miR-2116	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
DNASE1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33262
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
cardiac muscle cell contraction	GO Biological Process Annotations 2025	1.0	null
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942876
tolmetin-4088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87791
signaling	GO Biological Process Annotations 2015	1.0	null
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64218
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02571
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05185
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
BRD-K78088874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11116
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84295
hsa-miR-4723-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
clomipramine-3182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.079323
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
Familial episodic pain syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
TE-671 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15295
RRM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8246
cation-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
mantle zone of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07143
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18501
impaired glucose tolerance	MGI Mouse Phenotype Associations 2023	1.0	null
Hypokinesia	CTD Gene-Disease Associations	1.0	1.02447
Cerebellar cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21878
mRNA_TCEA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976396
BAIAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12206
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38581
BRD-K21449711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73792
PCYOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.37162
BRD-K54024474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35192
Perturb_16534_KO_Cdk8/Cdk19_SRP351257	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.42918
CDKN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61137
tsA-201 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.81
GSE111247_11_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
BRD-K19862308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01603
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Climbing fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
PTAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5048
PATU8988T	DepMap CRISPR Gene Dependency	1.0	2.14618
pheniramine-4012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1623	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CLCN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71111
U87	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14164
NCIH727	CCLE Cell Line Gene CNV Profiles	1.0	1.33217
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974507
rilmenidine-5532	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99939085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23453
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933186
Learning Disorders	CTD Gene-Disease Associations	1.0	1.35589
pentoxyverine-4649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.02634
response to pyrethroid	GO Biological Process Annotations 2015	1.0	null
Prolonged Pr Interval	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K78432605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06343
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.991265
hsa-miR-4711-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
BRD-K59683187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94076
EW7	DepMap CRISPR Gene Dependency	1.0	6.18261
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945553
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.628697
RPL36AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25069
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50772
HOXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5436
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
SEC31A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23271
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65033
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4706
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.975095
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Immunoglobulin subtype	InterPro Predicted Protein Domain Annotations	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.607319
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.13946
hsa-miR-9	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
BRD-K93675803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20271
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
PPP1R13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37662
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32778
PLSCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32771
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22069
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.97136
hsa-miR-4530	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Paranode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.901
hsa-miR-3119	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAF3IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57659
TOX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64595
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05997
Podosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.809
IRX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34185
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MQ-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.732574
MRPL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6804
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41939
cotinine-4650	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35904
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3454
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01559
GTEX-XMK1-0008-SM-4GICF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
regulation of sodium ion transmembrane transporter activity	GO Biological Process Annotations 2015	1.0	null
HTK	CCLE Cell Line Gene CNV Profiles	1.0	1.58661
DPY19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70863
BRD-K59701963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29099
GSE228413_4_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_3_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157S_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Heart ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.76
hsa-miR-4804-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
dystrophin-associated glycoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.267
PSME4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3486
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53186
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10117
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98647
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965638
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.344
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1291	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24216
r5 part of the oral Sp5 subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61608
RUFY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35245
GLB1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00366
Lung adenocarcinoma_LUAD_TCGA-55-6985-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE243491_3_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892394
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14851
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATP5MC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56087
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87265
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17579
flumethasone-pivalate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72148
Perturb_4478_KO_Prdm12_SRP334439	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.66106
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14119
TAFAZZIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93967
hsa-miR-4498	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.828762
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32553
hsa-miR-4768-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
GCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49307
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.08196
HSPB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33015
Ventricular Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3665
RPMI8402	CCLE Cell Line Gene Expression Profiles	1.0	1.40482
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03906
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7631
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29125
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826436
Lung cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
pallidal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28545
DHRS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68864
BRD-K20987582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18322
hsa-miR-543	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
ACACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27565
CBX2	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hsa-miR-2467-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
CRCGN015_MCF10A.TP53.M_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0678
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SNU761	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13581
inorganic cation transmembrane transport	GO Biological Process Annotations 2023	1.0	null
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01278
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22602
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09229
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99301
transporter activity	GO Molecular Function Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TGBC24TKB	GDSC Cell Line Gene Expression Profiles	1.0	2.14697
hsa-miR-509-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
BRD-K89660028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71367
BRD-K09607752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0639
PMC12549544-mmc2.xlsx-AA_D7_VS_D14-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041338
SLC39A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42142
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32844
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.898
HOXB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94591
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
B4GALT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51999
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37296
lateral posterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.875187
regulation of transporter activity	GO Biological Process Annotations 2015	1.0	null
PSKH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55992
RUNX1T1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82772
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78847
EXOSC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25352
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10982
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE146074_1_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51375
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_74_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922072
HUT78	CCLE Cell Line Gene Expression Profiles	1.0	1.44525
glis2_17618285_kidney_lof_mouse_gpl2897_gds2817	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.166966
BRD-A91931411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00193
familial atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.507657
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11087
Cardiovascular phenotype	ClinVar Gene-Phenotype Associations 2025	1.0	null
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59776
BRD-K75807957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45478
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930966
hsa-miR-575	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
BRD-K02610196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35992
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2054
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07594
GSE151829,GSE151831_1_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dravet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.35463
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4639-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
BRD-K91854399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35802
VMRCRCW	DepMap CRISPR Gene Dependency	1.0	2.60323
Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Syntrophin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.648
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9933
MYOCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3963
BRD-K05060234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70629
NUDT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58209
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08531
AMOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68714
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYO19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46564
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased susceptibility to induction of seizure by inducing agent	MPO Gene-Phenotype Associations	1.0	null
GSE186460_3_v_6_baricitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8082-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95526
CCND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87272
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
sodium	GeneRIF Biological Term Annotations	1.0	null
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89732
NELFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18391
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.950746
mRNA_NANOG_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
isocarboxazid-2562	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49464
Lung squamous cell carcinoma_LUSC_TCGA-22-4593-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fludroxycortide-4702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989112
brain	GTEx Tissue Gene Expression Profiles	1.0	2.18171
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058124
ZNF143	ENCODE Transcription Factor Targets	1.0	null
GTEX-TMMY-1026-SM-4DXTI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
lidoflazine-3201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42391
MSRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60459
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04827
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.12426
LINGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02378
BRD-K23701005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01755
ADHD and autism ASD pathways	WikiPathways Pathways 2024	1.0	null
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
iopromide-2739	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2662-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r2 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3216
Transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.132
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.09446
f11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
BRD-K10171338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58316
MDA-MB-435S cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SLC44A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90578
dipyridamole-4656	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-DX-A6B9-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDKN2AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40793
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
DHX38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5378-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.912
MAPK10	MSigDB Cancer Gene Co-expression Modules	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
ITK_knockout_242_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.53121
PRDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04936
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2609
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19376
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12376
GGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49481
Idiopathic Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.355126
molecular function regulator	GO Molecular Function Annotations 2015	1.0	null
hsa-miR-143	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ST18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67022
SAYSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80623
mRNA_SMAD7_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22789
GSE146074_1_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF816	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33614
PMC6089967__F2	PFOCR Pathway Figure Associations 2024	1.0	null
TDRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51651
BRD-K18296708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29314
hsa-miR-767-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
urinary bladder	HPA Tissue Protein Expression Profiles	1.0	0.828035
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38506
BRD-K02061146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32985
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45818
MRPS18C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4664
KDM6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73208
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7064
SCARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30169
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.868256
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GRHPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64351
Electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
AKT1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2699
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_99_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27120020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66609
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-125a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.02452
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
MBOAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36822
BRD-K03287885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41044
CBX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87273
BRD-A69786436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84646
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02297
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10774
GJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98627
heart_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.970561
hsa-miR-4770	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
BRD-K86953192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37563
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.149387
abnormal behavioral response to xenobiotic	MPO Gene-Phenotype Associations	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.095
GATA1	ENCODE Transcription Factor Targets	1.0	null
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-0.906338
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.01126
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
DDX59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35442
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29374
k1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
KE97	CCLE Cell Line Gene Expression Profiles	1.0	2.11822
BRD-K70412800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15788
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0528
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.127
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32553
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-125b	TargetScan Predicted Conserved microRNA Targets	1.0	0.02452
TP53	ChEA Transcription Factor Targets	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1005
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70238
ERVV-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63292
ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EJM	DepMap CRISPR Gene Dependency	1.0	2.05839
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06646
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.828035
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
STK35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31411
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.916067
OFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30376
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43082
GTEX-UJHI-0008-SM-4IHL1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hsa-miR-4434	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
REX1BD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22738
multicellular organismal signaling	GO Biological Process Annotations 2015	1.0	null
cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
SOX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72425
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37532736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43252
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050298
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49H-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COPS7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43988
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26328
GSE201309_1_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FBN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52317
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0658
RFLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8933
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Memory Disorders	CTD Gene-Disease Associations	1.0	1.41091
Brain Lower Grade Glioma_LGG_TCGA-FG-7643-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39271757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18182
hsa-miR-4264	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hsa-miR-4520b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
BHLHA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67896
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
hsa-miR-20b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ZNF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7203
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883611
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26938
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.270044
BRD-K84277608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23569
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.92898
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20232
hsa-miR-4708-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.21838
NCIH3255	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6776
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE195559_6_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07594
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11262
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.186
ChIP_TCF3_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K91085913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18186
CRCGN017_MCF10A.TP53.M_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1058
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL17RA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39338
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6253
FOXP1	ChEA Transcription Factor Targets	1.0	null
developmental process	GO Biological Process Annotations 2015	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987899
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044144
CREB1	ChEA Transcription Factor Targets	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902452
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0621
CAL-85-1	GDSC Cell Line Gene Expression Profiles	1.0	1.59622
adhesion	GeneRIF Biological Term Annotations	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.867567
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.90244
hsa-miR-3918	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
KCNH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12246
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.041506
Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41828
TCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21386
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.965374
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057672
Interaction between L1 and Ankyrins	Reactome Pathways 2024	1.0	null
SLC6A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84205
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.38144
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15464
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17709
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987599
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68747
hsa-miR-7	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
CENPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82082
Type II spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
ZNF586	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13583
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33013
ventral linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07143
d11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
Long QT syndrome 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.881
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTF2A1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25113
lncap cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217762
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25883
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.888302
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.25353
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990869
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.06
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7948
epilepsy	GeneRIF Biological Term Annotations	1.0	null
BRD-K17367110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06174
GSE149903_4_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00284
TMEM30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14783
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33635
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
Main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.653
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.59698
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28805
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77595
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8465
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K37912617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70041
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
NUMBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33373
hypertension	GWASdb SNP-Disease Associations	1.0	0.549267
hsa-miR-4302	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39322
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065084
TFB2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82784
ZFAND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31598
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06631
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.850814
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.461078
ZNF596	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36412
BRD-A16827030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28929
MED24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95572
placenta_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.883347
Otitis Media	DisGeNET Gene-Disease Associations	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22357
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08552
TP53-22127205-IMR90-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K31197843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55877
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26208
hsa-miR-605	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
lateral part of alar p2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03007
FNDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83312
atrial fibrillation;	GAD Gene-Disease Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8582-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPEN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09309
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11718
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cardiac conduction	GO Biological Process Annotations 2025	1.0	null
BRD-K41809257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30878
MRPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39965
ZNF384	ENCODE Transcription Factor Targets	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.048093
SH2B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6517
LIMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63797
BRD-K56470219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16812
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851539
NCOA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5654
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.915726
Prostate adenocarcinoma_PRAD_TCGA-HC-8260-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10521
HCN channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.296
s1391	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.191
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7603494-41467_2020_19353_MOESM6_ESM.xlsx-Ch_TCF3_up_and_binding_Overlapp-Unnamed_1_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
Long QT syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
GSE174418,GSE174421_0_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
denatonium benzoate-5061	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
cardiac muscle cell action potential involved in contraction	GO Biological Process Annotations 2023	1.0	null
voltage-gated sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.503
parvicellular (lateral) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26311
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70814
CARD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75335
OPLAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69839
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23342
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.2418
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sodium channel regulator activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.21944
Syncope	DisGeNET Gene-Phenotype Associations	1.0	null
laterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06101
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC19A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08714
cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.071124
BRD-K33979719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07736
Plasma membrane protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-M54814689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03226
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03174
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.16221
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7129-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.52608
Lung adenocarcinoma_LUAD_TCGA-93-A4JP-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34074
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
estropipate-2506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
RAD21	ENCODE Transcription Factor Targets	1.0	null
cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
molecular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37652
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
HOS	CCLE Cell Line Gene CNV Profiles	1.0	2.74674
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4324	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
CSNK2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22257
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.11116
hsa-miR-501-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01859
HOXD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39323
KMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31571
MYCN-19997598-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
DTX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20979
Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03805
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
FGF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77437
GTEX-WEY5-1926-SM-3GIL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97364
Paroxysmal Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
cardiac muscle cell action potential involved in contraction	GO Biological Process Annotations 2025	1.0	null
RYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83938
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05441
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebellum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13443
r2 part of principal trigeminal sensory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74229
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
L-type voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.682
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40346
regulation of sodium ion transmembrane transporter activity	GO Biological Process Annotations 2023	1.0	null
ZNF174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40686
GYG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51791
regulation of heart rate by cardiac conduction	GO Biological Process Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30469
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.973
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83028
RBM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30643
C10orf105	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38981
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.900583
BRD-K27331198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28829
U118MG	DepMap CRISPR Gene Dependency	1.0	4.42387
UCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29716
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A7DR-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
infancy electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.33458
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3BM-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06763
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6C-Table_S6C_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_PRAD_CIC_Del_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
sodium ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
OBSCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09505
SLC25A19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27732
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68305
BRD-K14695590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48065
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16761
Triglycerides Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
EIF2AK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71722
UBE2Q2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40836
membrane part	GO Cellular Component Annotations 2015	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.77561
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31164
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053861
Atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.944
CBX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55518
Olfactory tubercle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
migration	GeneRIF Biological Term Annotations	1.0	null
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97559
CHST13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6506
PMC6089967__F2	PFOCR Pathway Figure Associations 2023	1.0	null
SPRY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52003
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	GO Molecular Function Annotations 2023	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
SRC_activemutant_51_GSE15815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.2507
TPRG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21875
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02997
biological regulation	GO Biological Process Annotations 2015	1.0	null
SMZ1	DepMap CRISPR Gene Dependency	1.0	4.64372
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02121
CGGBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71848
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.355126
ADCY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81167
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CMTM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75634
Lung adenocarcinoma_LUAD_TCGA-38-4627-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.148
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68305
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.890212
KXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37482
IRX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97114
BRD-A46566149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17147
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62646
levonorgestrel-2547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09005
hsa-miR-204	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
TSFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29092
hsa-miR-3127-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.246703
HNF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99249
Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41377
Nervous system development	Reactome Pathways 2024	1.0	null
Nerve plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918006
propoxycaine-3583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8648-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
GSE201217_3_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal seizure response to pharmacological agent	MPO Gene-Phenotype Associations	1.0	null
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18287
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14255
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968157
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14287
BRD-K74826740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16345
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37176
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56367
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04413
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51781
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_NR2F2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K90157100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33905
hsa-miR-4763-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
JMY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57921
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IST-SL1	GDSC Cell Line Gene Expression Profiles	1.0	1.80046
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TTC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9452
1-EBIO	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06915
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899064
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10626
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EGR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87676
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-NEUN_UNIQUE_DYS_GENES-OLIG2_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.036
Perturb_14705_KO_Col1a1_SRP198671	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.9019
SLC7A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85958
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956721
Cation channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23663
BRD-K61756858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13212
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.14711
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SETDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28233
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8716
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94142
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
hsa-miR-502-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2338
voltage-gated cation channel activity	GO Molecular Function Annotations 2015	1.0	null
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35193
SLC17A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10644
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47195
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050479
ULBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64885
Dk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.719
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10404799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81139
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848682
cation transport	GO Biological Process Annotations 2015	1.0	null
THOC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00538
sodium channel regulator activity	GO Molecular Function Annotations 2015	1.0	null
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221291
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.68275
FOXF2	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8441-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12615346-mmc1.pdf-116-SATB1_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K42671829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12324
SU-DHL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38463
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22161
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2156
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53386
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
kidney disease	GWASdb SNP-Disease Associations	1.0	1.2092
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Epilepsies, Myoclonic	HuGE Navigator Gene-Phenotype Associations	1.0	null
heart	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941079
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87344
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
MROH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79293
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60916
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881755
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45043
GSE185881,GSE185884_2_v_3_ctcf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3194-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05353
amygdaloid complex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.904615
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32377
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02804
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8878
nervous system development	GO Biological Process Annotations 2015	1.0	null
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.271
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69626
mRNA_FEM1B_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
internal granular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73547
disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68323
BRD-K61416283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17461
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39893
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12015
PDE10A_KO_GDS4542_292_mouse_hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050752
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050749
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9263
JUND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59694
hsa-miR-635	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
SMYD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32446
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870611
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.68912
C1orf52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51266
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36284
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
system process	GO Biological Process Annotations 2015	1.0	null
JNK_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
ZNF101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58361
regulation of localization	GO Biological Process Annotations 2015	1.0	null
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03617
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Calu-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5782
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K08438266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44689
BRD-K59399000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03394
Perturb_15070_KD_Twist1_SRP150075	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27268
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83504
WWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89614
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.060977
Brain Lower Grade Glioma_LGG_TCGA-HT-7474-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13098
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308612
C1orf226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44164
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.825481
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056708
cardiac muscle cell action potential involved in contraction	GO Biological Process Annotations 2015	1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K34812979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10841
NRDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15456
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.103543
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VANGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15859
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNAJB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4087
WM88	CCLE Cell Line Gene CNV Profiles	-1.0	-2.39264
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25053
Long QT syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.208
Atrial fibrillation	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
ERBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5018
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0015
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMRT1	ChEA Transcription Factor Targets	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70579
Hypertension	CTD Gene-Disease Associations	1.0	1.07518
hsa-miR-873	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5956
eGFP-FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RUSQ-0426-SM-47JWR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952018
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
striated muscle contraction	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4787-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K56427898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24995
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
EFEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50445
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25132
Perturb_15082_KD_Ehmt1_SRP354984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SMIM10L2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0197
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of sodium ion transport	GO Biological Process Annotations 2015	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.212549
LRATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82559
hsa-miR-3130-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GSE135350_3_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRAPPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45967
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992786
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
RAD21	ChEA Transcription Factor Targets	1.0	null
bioallethrin	CTD Gene-Chemical Interactions	1.0	null
epilepsy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.3869
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07258
FAM43A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37521
hsa-miR-4283	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
B4GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83391
JUN	ENCODE Transcription Factor Targets	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.045013
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51132
Perturb_3266_KO_mir181a1/mir181b1_SRP015851	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.0588
KE39	CCLE Cell Line Gene CNV Profiles	1.0	1.60043
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04884
SMIM30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71257
CLDN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67134
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.905
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
FKBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46059
TEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19889
ZNF880	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19488
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE210885_3_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TTLL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89274
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43401
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05872
OCIMY5	CCLE Cell Line Gene CNV Profiles	1.0	2.3967
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clioquinol-6461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62758
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.955062
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865376
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ion channel regulator activity	GO Molecular Function Annotations 2025	1.0	null
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.87225
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3141	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
hsa-miR-519b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
KLF4	ChEA Transcription Factor Targets	1.0	null
display	GeneRIF Biological Term Annotations	1.0	null
RNA helicase p68_KD_GDS2152_625_mouse_skeletal muscle cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.287
JJN3	DepMap CRISPR Gene Dependency	1.0	2.72171
ELOVL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54013
DUSP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48641
CRCGN016_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3561
BRD-K70652938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31063
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35494
2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	CTD Gene-Chemical Interactions	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45074
Genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACADSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15865
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.50198
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4496_KO_Hnf4a_SRP139365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.0273
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12779
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
SRSF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14719
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.905894
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96325
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36372
BRD-K03659510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39573
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04541
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35169
KDM4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7052
hsa-miR-4529-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
hsa-miR-374a	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
SEC24C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15747
BRD-K66032509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12698
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.65245
HEL9217	CCLE Cell Line Gene CNV Profiles	1.0	2.1301
GPR153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82721
LGALS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99239
hsa-miR-4776-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.51875
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.295739
TMEM168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.966
SMC3-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0568
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18404
Perturb_16651_KD_Fus_SRP179634	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81977
DNM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81683
eye and adnexa disease	GWASdb SNP-Disease Associations	1.0	0.162079
Visual Seizure	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88052
E2F8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97546
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.06698
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14854
Right bundle branch block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.159
regulation of heart rate	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC893	DepMap CRISPR Gene Dependency	1.0	2.01801
meclofenoxate-2546	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4436b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
BRD-K81246784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39945
BCL11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15988
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
GSE189653,GSE203344_2_v_0_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6950-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08221
nadide-7227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.11912
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMC3IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98622
Perturb_4468_KO_Cnr1_SRP346447	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.84181
KCTD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12814
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57711
BRD-K27534253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28464
ATP1A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05511
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58922
BRD-K80066561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73766
doxycycline-2737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K02199688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46048
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26919
BRD-K18074484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22866
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22599
ANP32D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11712
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SECISBP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48157
Left atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.601
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87158
increased heart left ventricle size	MGI Mouse Phenotype Associations 2023	1.0	null
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.57165
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25584
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A07195938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32874
hsa-miR-326	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2497
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41878
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.48
KML1	DepMap CRISPR Gene Dependency	1.0	7.95292
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59836
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19991
shikonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26657
BRD-K73730918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43483
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829617
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.51439
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04487
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32553
Lung squamous cell carcinoma_LUSC_TCGA-21-1079-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_18400_KO_Wnk1_SRP247391	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.84166
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.979621
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11058
FERD3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03761
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4168
hsa-miR-34c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
CRCGN010_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15277
GTEX-OHPN-0008-SM-4E3HW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08202
FAM168B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7005
ZNF248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61044
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2817-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4685-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27285
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	1.83153
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842238
Preeclampsia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058031
BRD-K77808555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43358
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30579
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Sodium	HMDB Metabolites of Enzymes	1.0	null
CHOP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PKN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83714
BRD-A03182941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14326
membrane depolarization during action potential	GO Biological Process Annotations 2025	1.0	null
first-degree atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
hsa-miR-330-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93551
HAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58128
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_11_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23201
mantle zone of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46041
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.958158
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-IE-A4EK-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849028
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055571
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPM1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7115
Polygenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.676
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96392
Right ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.802
RPL41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36019
GTEX-XPVG-2926-SM-4B66G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01856
BRD-K44549496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02751
PTGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30306
hsa-miR-4774-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
cardiac muscle contraction	GO Biological Process Annotations 2023	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948926
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868405
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05294
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hydrastine hydrochloride-6011	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.485885
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46702
BRD-K04992384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09306
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868279
BRD-K13761649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01767
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52702
hsa-miR-449b	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
NCIH1573	DepMap CRISPR Gene Dependency	1.0	3.37524
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.18197
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51163
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02201
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
hsa-miR-4677-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46626
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82546
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093031
BRD-K48113764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08008
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03129
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60227
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64313
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CBLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55711
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.68026
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MEWO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34695
heart	GTEx Tissue Gene Expression Profiles	1.0	1.14569
GTF2IRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32551
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.914637
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5165
channel	GeneRIF Biological Term Annotations	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899064
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.856
LCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28264
BRD-K88997070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07442
POTEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60589
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33414
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A25993094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93203
Benign familial infantile epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.397
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870601
Inflammation	CTD Gene-Disease Associations	1.0	1.33583
BRD-K85775326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02316
cell part	GO Cellular Component Annotations 2015	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.78194
Brugada Syndrome	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-4476	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
rosiglitazone_mus musculus_gpl7202_gse19896	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82606
PMC8816717-mmc2.xlsx-TgCRND8_P113-Unnamed_2_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07691
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860754
SKMEL30	DepMap CRISPR Gene Dependency	1.0	3.38231
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
BRD-K79555196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36436
HPDL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68763
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-OLIG2_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.633
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.79562
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PU-01A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72399
ZNF624	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76894
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
charcot-marie-tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.437906
BRD-K30964167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24004
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-455-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L3MBTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2108
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94653
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60381
Pancreatic adenocarcinoma_PAAD_TCGA-3E-AAAZ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33537
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4736	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K21753319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55976
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25935
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
ZC3H11A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-211	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19508
anterograde trans-synaptic signaling	GO Biological Process Annotations 2025	1.0	null
Perturb_15081_KD_Crebbp_SRP354984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.308118
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84159
GSE231799_3_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7315-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92607052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56901
regulation of heart rate by cardiac conduction	GO Biological Process Annotations 2023	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90977
Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861536
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90016
Anterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10501
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843318
RT-112	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53521
EPN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20435
UMC-11	GDSC Cell Line Gene Expression Profiles	1.0	1.96662
12096084-Figure3-1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K51298794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95763
SMAD4-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCIH1694	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68816
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847358
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
R-atenolol-4259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50525
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.42178
LATS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4429
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31908
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69528787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60003
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.337
PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5270-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB7_01_170	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.61391
RALA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29058
hsa-miR-3175	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42943023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11053
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38407
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.2418
MIX23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66186
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NDUFS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37688
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30967
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14025
Right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.89
C-fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
BRD-K09871160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0241
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15989
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
Paroxysmal extreme pain disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.015
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846664
hsa-miR-657	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
DEK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78693
BRD-K98016463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55485
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873513
NECAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11286
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22948
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
decitabine-920	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
ZNF587B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46631
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01072
CTCF-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K15028515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50306
Absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2275
Ventral posteromedial nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2481
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.253248
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-2.094
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44923117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96043
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.333
parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.354455
CTU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61868
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1526
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased susceptibility to pharmacologically induced seizures	MPO Gene-Phenotype Associations	1.0	null
BRD-K29258781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23803
ventral nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17854
TMSB4Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88702
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13615
neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.085506
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.19591
SNRNP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69059
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.85758
Treacher Collins syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896415
MAX	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-545	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1473
BRD-K57830670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01992
long qt syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.408666
647-V	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60907
DPEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63158
TMEM208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65989
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72573
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.24812
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Lung adenocarcinoma_LUAD_TCGA-44-3396-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
anthraquinone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05597
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38526
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00554
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1233
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.932
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.865154
HCC1195	CCLE Cell Line Gene CNV Profiles	1.0	1.51346
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TOR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81921
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.923848
Parafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50099
BRD-K94205659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37871
TMEM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60291
C2CD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42816
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.58861
NUDT19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20843
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
CerebellumPeduncles	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08802
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.62129
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.09458
Cardiac conduction	Reactome Pathways 2024	1.0	null
superficial stratum of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81424
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal eye morphology	GWASdb SNP-Phenotype Associations	1.0	0.160272
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28238
BRD-K45307863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07122
localization	GO Biological Process Annotations 2015	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864399
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NEK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93589
EIF4G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22007
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02309
abnormality of higher mental function	GWASdb SNP-Phenotype Associations	1.0	0.247719
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856719
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43321
BRD-K02274100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05392
Phase 0 - rapid depolarisation	Reactome Pathways 2024	1.0	null
GTEX-QDT8-0008-SM-48U2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983029
Stichosome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7541
PLEKHH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15489
ANTXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21695
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87035
lorglumide-4658	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
TSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96735
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.872
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Biceps brachii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
CRCGN016_MCF10A.TP53.M_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01629
Tachycardia, Ventricular	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FBXO27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90672
Lobule III	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13443
U343	CCLE Cell Line Gene CNV Profiles	-1.0	-2.50911
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13076
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830643
Lung adenocarcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.509
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Purkinje cell layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21206
L1CAM interactions	Reactome Pathways 2014	1.0	null
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058634
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33503
hsa-miR-3977	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.828035
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.868124
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane depolarization during cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
r3 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01697
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27043
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.964511
retinal disease	GWASdb SNP-Disease Associations	1.0	1.2092
Peptonephridium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
JURKAT	DepMap CRISPR Gene Dependency	1.0	4.71546
hsa-miR-4259	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
PAOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16438
Pain disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
BRD-K75724196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12992
EP300	ENCODE Transcription Factor Targets	1.0	null
HS742T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85631
I-cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01467488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13605
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.870001
HS281T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01256
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP3K21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64453
GTEX-PX3G-0926-SM-48U12	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929234
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061756
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6959-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heart disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
BRD-K89832379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81968
BRD-K80996561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52972
Other Specified Cardiac Arrhythmias	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K69817695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27608
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045601
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19539
brugada syndrome	GAD Gene-Disease Associations	1.0	null
placenta	HPA Tissue Protein Expression Profiles	1.0	0.828035
USF2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67403750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20994
COG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53438
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962704
FAM72A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86597
BRD-K33221810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11398
Developmental and epileptic encephalopathy 52	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
MFF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99543
UBE2O	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8098
ARF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72964
HCC38	CCLE Cell Line Gene Expression Profiles	-1.0	-1.96059
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.93082
L-methionine sulfoximine-4070	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QS-01A-61R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prostate cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067147
Dendritic filopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
mRNA_TCF7L2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05236
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53528
hsa-miR-328	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
BTN2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36976
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69453266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20112
BRD-K36196444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24997
Breast Cancer_Mammary Gland Tissue_GSE3744	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.46051
Perturb_17917_KO_Shank2_SRP314506	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.43884
GSE115363_2_v_4_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16553
hsa-miR-492	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964971
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92377
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60682
MDFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45583
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48852
substrate	GeneRIF Biological Term Annotations	1.0	null
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1229
hsa-miR-150	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07143
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67085
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041088
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65996
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08515
Sodium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Sarcoma_SARC_TCGA-DX-A2J4-01A-32R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968894
raloxifene-2738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UMRC6	CCLE Cell Line Gene Expression Profiles	1.0	1.36965
pravastatin-lactone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14942
BRD-K89551737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48096
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NBEAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3675
RBPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73445
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Cerebellum	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.54277
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88312
GTEX-RUSQ-0326-SM-47JWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936003
Mediodorsal nucleus of the thalamus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4706
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.904476
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fragment	GeneRIF Biological Term Annotations	1.0	null
TXNL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34297
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-HB-A3YV-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEKHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48207
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of ion transport	GO Biological Process Annotations 2015	1.0	null
sensory system disease	GWASdb SNP-Disease Associations	1.0	0.137278
abnormal hemoglobin	GWASdb SNP-Phenotype Associations	1.0	1.05775
MRRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04924
Sarcoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.876
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06094
hsa-miR-218	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
Atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.331
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21757
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.417718
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
proguanil-3505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91066
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.054004
Epilepsy	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K39584933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00001
GTEX-T5JW-0926-SM-4DM5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058031
heart disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5636-01A-02R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
SMAD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33468
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19333
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1105	CCLE Cell Line Gene CNV Profiles	1.0	1.60822
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
hsa-miR-1323	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
HOXC9	ChEA Transcription Factor Targets	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38407
CH25H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24383
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GLS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90483
Lung squamous cell carcinoma_LUSC_TCGA-90-6837-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37498
RAB24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50917
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28186
Long QT syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.835847
Copula pyramidis, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09924
SPIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71769
ADCY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70764
ASMTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14155
SCARF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13478
BRD-K06220918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33359
GTEX-XOTO-0008-SM-4GICE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
TEKTIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02369
STK24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53897
RNPEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.587
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
ENTPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26604
GSE94011_2_v_1_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r6Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23627
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910596
Sinoatrial node disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.32
TLE5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99414
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.898951
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C6orf47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67016
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Sodium channel subunit beta-2	InterPro Predicted Protein Domain Annotations	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.845
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.81545
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28363
EGR1	ChEA Transcription Factor Targets	1.0	null
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Short QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.335
SUM52PE	DepMap CRISPR Gene Dependency	1.0	2.92629
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.04
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16507
subethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84825
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.662742
Perturb_8536_KD_Rbfox1/Rbfox3_SRP062242	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.93536
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928607
Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tranylcypromine-2264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K74475430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11366
TRDMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36396
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860855
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCIH526	CCLE Cell Line Gene CNV Profiles	1.0	2.0535
RPL29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15908
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.48321
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.526904
CKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29233
Ventral medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08802
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4903
ANKZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55118
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.08337
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MLMA	COSMIC Cell Line Gene CNV Profiles	1.0	2.14116
CCNE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04909
TDRD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9205
Andersen-Tawil syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
TRMT61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06346
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1667
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
ZONISAMIDE	DGIdb Drug Targets 2026	1.0	2.2055
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01526
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69571
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863205
Immunoglobulin-like fold	InterPro Predicted Protein Domain Annotations	1.0	null
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02201
BRD-K07473245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02367
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.85117
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893731
Sleep	HuGE Navigator Gene-Phenotype Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Lung adenocarcinoma_LUAD_TCGA-55-6982-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4786-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
prostate	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	1.2092
SHANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40561
NCIH2110	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60215
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045785
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97667
RBM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64875
Kidney Chromophobe_KICH_TCGA-KM-8439-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pilocarpine	CTD Gene-Chemical Interactions	1.0	null
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.92303
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58179
Sinus Node Dysfunction (Disorder)	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TEX45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14495
Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3731-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATG101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39016
Digenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.661
cortex of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51163
rara_21299862_mcf7_lof_human__gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.06358
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975651
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.861243
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PDCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30067
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.801282
PITX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81416
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29069
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3799
TAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59862
HCC1195	CCLE Cell Line Gene Expression Profiles	1.0	2.99505
PRMT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01492
FARAGE	DepMap CRISPR Gene Dependency	1.0	5.01508
DYRK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67181
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2587
sodium ion transport	GO Biological Process Annotations 2023	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.920619
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1357
nfe2l2_23639809_whole_esophagus_lof_mouse_gpl7202_gse39629	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.347469
SLC35B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43157
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12688
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881822
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3479
Lung adenocarcinoma_LUAD_TCGA-44-2661-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
West syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTPRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8012
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37652
hsa-miR-522	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
Lobule III, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39423
DDX47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02299
BRD-K25822126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01249
trend	GeneRIF Biological Term Annotations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_66_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02679
PLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36402
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10414
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942877
GRIN2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18321
PTPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39246
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.006
OCILY10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51087
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4571
KMT5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86755
NCIH596	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48485
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7792-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88827
MPLKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94046
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4363
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66225
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44314
regulation of sodium ion transport	GO Biological Process Annotations 2025	1.0	null
BST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39723
single organism signaling	GO Biological Process Annotations 2015	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of ion homeostasis	GO Biological Process Annotations 2015	1.0	null
Death, Sudden	HuGE Navigator Gene-Phenotype Associations	1.0	null
Carapace	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06059
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50028
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218398
Sensory perception of taste	Reactome Pathways 2024	1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97458
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12086_OE_Esr1_SRP050547	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.3294
cardiac muscle cell action potential	GO Biological Process Annotations 2015	1.0	null
EB-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26795
ABCG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51013
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872499
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
BRD-K79355381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07029
RPUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96428
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28363
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063733
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF878	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11207
SLC25A22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72227
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84397
EEIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86131
Infancy electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
RCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87317
HDAC1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234647_1_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
PPP1CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5798
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6018-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paclitaxel_rattus norvegicus_gpl890_gse5337	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44833533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77857
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77704
BRD-K49215099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0868
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hsa-miR-3144-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994187
carbenoxolone-4093	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BPHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27657
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35066
hsa-miR-208b	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64488
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A27693633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12924
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.842002
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.3163
hsa-miR-374b	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
sodium channel regulator activity	GO Molecular Function Annotations 2025	1.0	null
hsa-miR-499-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
Brugada syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
cation channel activity	GO Molecular Function Annotations 2015	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4236_KD_Cnot7_SRP091584	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.63652
MM-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8630-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PARK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83236
HCT15	DepMap CRISPR Gene Dependency	1.0	4.65631
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12206
SYT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60114
RREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6995
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_KLF4_19030024	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12494
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10982
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC10591418-12711_2023_849_MOESM11_ESM.xls-AA_3W_vs_LS_3W-gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846997
FPGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27672
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20311
RPUSD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13238
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
LPCAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81917
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
BRD-A84941884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4519
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.39454
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NCIH196	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03671
brugada syndrome	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
RNASE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59858
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1478
BRD-K48050202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40292
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00811
Prostate adenocarcinoma_PRAD_TCGA-VP-A87E-01A-31R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE2G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88604
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCAP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59896
ZFP64	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50001
Familial atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.961
MBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59586
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0704
PMC3930188-813067.f1.pdf-124-SATB1_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92644013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19329
RERE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21655
BRD-K94692455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19917
hsa-miR-3921	TargetScan Predicted Conserved microRNA Targets	1.0	0.015875
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7515
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0016
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
voltage-gated sodium channel complex	GO Cellular Component Annotations 2015	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4755
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73547
FN3KRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43573
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49555
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16855
19658189-TableS5	GeneSigDB Published Gene Signatures	1.0	null
MRPS34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54552
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	4.67942
GSE173873_8_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-615-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
MAZ	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4753-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.02452
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946269
16288011-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3049
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
Infantile Severe Myoclonic Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
SH3PXD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45031
GIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20674
FMNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33753
Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
DCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65705
PMC8104016-hcg-12-e002353-s010.xlsx-mTHP1-LPS_30kb-Nearest_reported_Gene_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM106C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52332
BRD-K91548063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11369
LUC7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01096
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CXCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76537
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06889
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18142082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23495
Erythromelalgia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96584
Perturb_6667_KD_PRMT5_SRP310288	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hsa-miR-449a	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.057409
NPY1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05518
sodium channel complex	GO Cellular Component Annotations 2023	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13144
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.87916
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65682
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.564112
LK-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cognitive impairment	GWASdb SNP-Phenotype Associations	1.0	0.530515
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CACNG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50749
MSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74546
buflomedil-4258	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11027431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3282
FBXO28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2558
ARL4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95341
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54827
seizures	MPO Gene-Phenotype Associations	1.0	null
Perturb_14869_KO_PU.1_SRP166067	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K01095342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76908
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68305
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of membrane depolarization	GO Biological Process Annotations 2015	1.0	null
ATOH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25892
hsa-miR-4703-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CDX1_CDX1	Rummagene Transcription Factor Associations 2026	1.0	null
required	GeneRIF Biological Term Annotations	1.0	null
cardiac muscle contraction	GO Biological Process Annotations 2025	1.0	null
ARHGAP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50784
DDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8463
NANOG	ChEA Transcription Factor Targets	1.0	null
PSRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48982
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81897236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10139
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44572
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_CBX8_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
S1PR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66414
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61782
I band	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.268
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49931
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
SW948	DepMap CRISPR Gene Dependency	1.0	2.41516
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040864
Daudi	GDSC Cell Line Gene Expression Profiles	1.0	1.75036
ZNF808	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05247
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TMEM82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73899
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
MECOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28401
FIP1L1_02_103	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.52356
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3287
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1114
BRD-K96491664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13207
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.563335
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12376
HT	CCLE Cell Line Gene CNV Profiles	1.0	2.7302
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989736
Primary dilated cardiomyopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
GTEX-PW2O-0008-SM-48TEB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
PKN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66674
BRD-K05957858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2316
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94477
Perturb_15341_KI_ORP4L_SRP367235	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.45807
hsa-miR-641	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
UCHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50787
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IVD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30347
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sodium channel complex	GO Cellular Component Annotations 2025	1.0	null
FBXL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84608
ARG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7088
MBD3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05735
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	2.17871
BRD-K64257929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43523
EEF2KMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40706
system development	GO Biological Process Annotations 2015	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.957664
chemical synaptic transmission	GO Biological Process Annotations 2023	1.0	null
isthmic alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35066
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895108
BRD-K48448518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20112
SPG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73123
isthmus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18518
cardiac conduction	GO Biological Process Annotations 2015	1.0	null
GSE158182_4_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846249
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911398
CACNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78769
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hsa-miR-888	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.079
Lung adenocarcinoma_LUAD_TCGA-55-7994-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855402
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843692
SLC26A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18956
CENPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09777
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.88025
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	1.99487
NCIH2110	DepMap CRISPR Gene Dependency	1.0	2.26713
ATP5PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08071
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.26721
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.076
ADAMTS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64832
SYTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16502
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55889
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17599
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
HPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15396
Atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.717
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28467
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3418
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEM-VBL100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
PDGFRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81725
hsa-miR-4651	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LMAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57896
SAP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91125
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052852
LLGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41889
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83343
BRD-K53456628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04523
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946946
BRD-K14470344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1432
Extrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.7673
COX6B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26079
cellular_component	GO Cellular Component Annotations 2015	1.0	null
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.905486
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41175
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brinzolamide-3230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RGMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10718
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35389
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81J-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17794
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40117
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941079
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-342-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87037
metoprolol-6846	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAP1LC3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98488
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSHZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42932
r1 part of vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16391
gfi1b_22201127_amulv_gof_mouse_gpl6246_gds4302	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.007682
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE217363_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6386
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31851
Right Bundle Branch Block	DisGeNET Gene-Disease Associations	1.0	null
GSE173873_4_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TP53-22127205-IMR90-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261624
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-331-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14699
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.53087
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125219,GSE125221_5_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12795
ATF3_01_33	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.21136
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08297
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.502292
BRD-K31805261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66689
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831585
Catecholaminergic polymorphic ventricular tachycardia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.075
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30721
RBBP5	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4260	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173873_10_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157S_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14395
quercetin-4264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CIAO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04757
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070968
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0907
Desmosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
Congenital heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04823
hsa-miR-940	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
PCGF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99894
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9375
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.57614
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64485
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2865
GSE192689_0_v_3_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiac Purkinje fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.407
regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
Generalized epilepsy with febrile seizures plus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.304
VMRCLCP	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45142
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cellcell	GeneRIF Biological Term Annotations	1.0	null
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spinal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.22
PANX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10941
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72734
SJSA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34546
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15252
Cerebellar granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.367
Sarcoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.534
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848184
BRD-K54007898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19132
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45356
5152487-896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K91506006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4018
Mediodorsal nucleus of the thalamus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26311
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959291
Immunoglobulin V-set domain	InterPro Predicted Protein Domain Annotations	1.0	null
Marsili syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.643
CARMIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51432
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4826
NMB	DepMap CRISPR Gene Dependency	1.0	2.3876
MFSD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91428
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16177
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
EFM-192A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.58983
Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26441
GTEx Thyroid 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	4.63249
CCDC102A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49627
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7913
mRNA_ATF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4117-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98272474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78659
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976043
synaptic transmission	GO Biological Process Annotations 2015	1.0	null
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08902
BRD-K25328765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22358
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930452
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.17732
PLAAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65541
Asthma_Epithelial Cell_GSE4302	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.71728
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07875
BRD-K08750028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39432
UIMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63409
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
membrane depolarization during action potential	GO Biological Process Annotations 2023	1.0	null
brugada syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.59519
Submedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03007
FNBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55131
heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.51281
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0226-SM-48TBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86628
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.870444
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059328
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0589
TFAP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39085
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95398
GSE143212_0_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OTOL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27617
NCIH1573	CCLE Cell Line Gene CNV Profiles	1.0	1.5422
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.27262
GSE125153_2_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02073410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10322
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Epileptic Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052016
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70284
SLC29A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38643
BRD-K56595246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98683
monoatomic cation transmembrane transport	GO Biological Process Annotations 2023	1.0	null
C1orf56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67029
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31598
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.976478
AR	ChEA Transcription Factor Targets	1.0	null
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19106
HCC-44	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K04067194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02971
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04758
CHD7	ENCODE Transcription Factor Targets	1.0	null
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.06354
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.990743
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875689
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Left ventricular noncompaction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
Trigeminal neuralgia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
mantle zone of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31524
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
t64-ovaries_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.95028
CCDC77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3101
PGP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64202
hsa-miR-20a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Sensory perception of sweet, bitter, and umami (glutamate) taste	Reactome Pathways 2024	1.0	null
RRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.64818
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
MME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75507
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC21H	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5162
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53776
Perturb_6217_KO_Mef2d_SRP227204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.791
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28545
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33099
KMS20	DepMap CRISPR Gene Dependency	1.0	2.18632
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980544
BRD-K43192646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56163
hsa-miR-4514	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055553
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.792848
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38535
BRD-K37262603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.61507
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7762
CD55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31747
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.291722
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.28452
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06586
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
BRD-K48864953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17928
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autonomic nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
MD MB231	BioGPS Cell Line Gene Expression Profiles	1.0	1.01432
PINLYP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70784
voltage-gated sodium channel activity	GO Molecular Function Annotations 2015	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
regulation of heart rate by cardiac conduction	GO Biological Process Annotations 2025	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.883702
hsa-miR-1910	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
naltrindole-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43255
BRD-K12396271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35461
KIZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46488
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.986521
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907781
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908402
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5697-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058893
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04595
prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061849
familial atrial fibrillation	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970208
APP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63123
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.70976
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69427
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05394
SLC27A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77792
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.898845
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
BRD-K34005205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91389
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
dorsal tier of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01052
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33985
posterior intralaminar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4903
Perturb_8602_KO_Mir132_SRP064164	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.02221
MOLT4	BioGPS Cell Line Gene Expression Profiles	1.0	0.91234
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
action potential	GO Biological Process Annotations 2015	1.0	null
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1526
response to chemical	GO Biological Process Annotations 2015	1.0	null
ZNF354C	JASPAR Predicted Transcription Factor Targets	1.0	null
ZNF738	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74262
KMS21BM	CCLE Cell Line Gene CNV Profiles	1.0	1.4716
cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46041
REM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14913
FAM83E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85374
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hsa-miR-4664-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
enhanced	GeneRIF Biological Term Annotations	1.0	null
AMER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18516
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.52763
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8305
mediodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11677
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76391
hsa-miR-4481	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.21411
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.607722
Endocardium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.585
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85635
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3170	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13277_KO_Bach1_SRP238575	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Cerebellar Purkinje cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.465
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19991
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02487
Lateral dorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27046
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-8454-11A-01R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39302
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6654
TOMM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7393
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MRPS23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88304
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37406
RIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5089
Sick sinus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.324
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ADH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20343
19658189-TableS8d	GeneSigDB Published Gene Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.249542
UNC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39924
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4123
SOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74504
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95495
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
18062813-GeneList	GeneSigDB Published Gene Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02617
BRD-K03602135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34805
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28742
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cardiac Arrest	DisGeNET Gene-Disease Associations	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934571
GSE141624_3_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09111
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04956
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
ASCL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82826
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
r6 part of spinal trigeminal nucleus, pars oralis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06848
hsa-miR-519d	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
KLF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66999
EGLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70663
GTEX-U8XE-0426-SM-3DB91	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926309
BRD-K94306568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59311
BRD-K43126701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30006
HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
regulation of ion transmembrane transporter activity	GO Biological Process Annotations 2015	1.0	null
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51981
Pulmonary venous myocardium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47609
RABL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74282
tonsil	HPA Tissue Protein Expression Profiles	-1.0	-1.2418
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898862
GTEX-UJHI-1926-SM-3DB8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00966
hsa-miR-4676-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vermal regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32575
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
WTIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56599
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05605336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26452
hippocampus (hippocampal formation)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995523
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
FKBP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8555
Arrhythmogenic right ventricular dysplasia 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.89794
FITM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91949
TRIM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45218
GSE65617_5_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.206913
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16318
RNASE8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52407
BRD-K01250897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20803
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842417
PYCARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73455
ME1	CCLE Cell Line Gene CNV Profiles	1.0	1.83816
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16553
GSE173873_1_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDAMB361	DepMap CRISPR Gene Dependency	1.0	3.53219
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MLX_TESTES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.36706
Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF2BPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09493
membrane depolarization	GO Biological Process Annotations 2025	1.0	null
CHAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96183
ZC3H18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69648
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09669
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32802
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57688
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF746	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15254
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944196
BRD-K74862734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68958
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947553
BRD-K09373762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38385
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	2.4279
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87022
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12378
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.45567
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO678	DepMap CRISPR Gene Dependency	1.0	2.65764
Palpus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32713
monensin-2580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2911-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38526
PMC12648952-12915_2025_2452_MOESM4_ESM.xlsx-S4c-Pseudobulk_AP2_vs_B57-Unnamed_11_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
FOXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12415
intermediate stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18518
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.747
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060974
KLE	CCLE Cell Line Gene Expression Profiles	1.0	2.71851
SEZ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19089
Prostate adenocarcinoma_PRAD_TCGA-G9-6384-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KARPAS422	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34565
CCAR2_02_86	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.0
WDR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77845
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.40757
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
mantle zone of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01052
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF542P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73681
16818684-Table2c	GeneSigDB Published Gene Signatures	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08475
HS2ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69716
PCNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74889
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4266	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15553
PTPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31049
DPH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73922
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Somatoform disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
Heart valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
TBC1D24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55832
Mediodorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19874
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50634
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34619
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
hsa-miR-938	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
Kidney renal clear cell carcinoma_KIRC_TCGA-T7-A92I-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04667232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08464
gammasecretase	GeneRIF Biological Term Annotations	1.0	null
sodium channel activity	GO Molecular Function Annotations 2015	1.0	null
Integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-375	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
HUNS1	CCLE Cell Line Gene Expression Profiles	1.0	1.75996
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.85284
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0562
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.85593
Episodic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47661
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980243
Orbital area, lateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06616
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.44513
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7A-GENE_LIST_UPLOADED_TO_ENRICHR_MLX_TESTES_855_GENES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46515
MRPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04811
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.951728
sulfachlorpyridazine-6046	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TGIF2LX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0459
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02487
GSE146074_6_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40602242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34341
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20514
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68209
Brugada syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.123
reticular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75367
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98912
increased susceptibility to pharmacologically induced seizures	MGI Mouse Phenotype Associations 2023	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.843119
GTEX-W5X1-0008-SM-4LMKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970989
PMC11618586-41467_2024_55008_MOESM1_ESM.pdf-16-ZNF654_ZNF654	Rummagene Transcription Factor Associations 2026	1.0	null
NMRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62739
BRD-K11389666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19252
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.459
Z disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.066
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842575
Lung squamous cell carcinoma_LUSC_TCGA-85-A4JB-01A-51R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30192
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987665
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.860964
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971597
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H8-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969088
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20848
regulation of membrane potential	GO Biological Process Annotations 2015	1.0	null
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46023
697	CCLE Cell Line Gene Expression Profiles	1.0	1.46073
A-Netherlands-602-2009(H1N1)_3Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58376
Perturb_16853_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.49435
Superior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
GTEx Brain 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-12.1845
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2002
PMC5007654-srep32566-s2.xls-DISEASE_GENE-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3013
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050508
BRD-K31584969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55241
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.4382
SHCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66041
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.04647
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01366
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951364
Tonic - Clonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-550a	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12705_KO_Tsc2_SRP227934	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.2832
PHOSPHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9306
GSE173873_2_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88984
hsa-miR-494	TargetScan Predicted Conserved microRNA Targets	1.0	0.015875
Adrenal glomerulosa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.892
RXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92334
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CingulateCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.8572
hsa-miR-4459	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
MAP3K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22324
TBC1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26818
Nkx-2.5 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.3
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVSAHO	CCLE Cell Line Gene Expression Profiles	1.0	2.40871
Acute Lung Injury_Whole blood_GSE10474	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.20187
lateral part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07691
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inner SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.835639
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12376
SARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76214
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4974
TFDP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17772
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
vascular disease	GWASdb SNP-Disease Associations	1.0	0.066998
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MAP3K11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08491
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_12_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
T-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.675
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0957
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.877085
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02512
BRD-K12336887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88352
BRD-K55642725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67451
LPAR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26599
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.44627
SLITRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87964
chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.070004
Central lateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.42776
Atrial appendage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
H2AC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47255
Dravet syndrome	WikiPathways Pathways 2024	1.0	null
SLC1A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02413
ZC3H11A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of erythrocytes	GWASdb SNP-Phenotype Associations	1.0	0.319931
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30013099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12842
Peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.625
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.673
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	1.05775
COCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98995
Principal sensory nucleus of the trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45675
NUP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18627
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Respiratory system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
GCHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35845
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Type IC spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74318
voltage-gated sodium channel activity	GO Molecular Function Annotations 2023	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3812
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC22A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74698
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69176
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09156
hsa-miR-2276	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
ELN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24352
SW620	BioGPS Cell Line Gene Expression Profiles	1.0	1.0247
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37652
CTCF	ENCODE Transcription Factor Targets	1.0	null
TFAP2A	ChEA Transcription Factor Targets	1.0	null
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2183
BRD-K50587003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17554
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55919
SFRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34031
SUOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51534
BRD-K56339035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7095
GJB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04732
Prestwick-682-6638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88078
regulation of atrial cardiac muscle cell membrane depolarization	GO Biological Process Annotations 2025	1.0	null
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-1207-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
sodium:potassium-exchanging ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.789
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Left ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.377
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29756
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8591_KO_Fto_SRP097869	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.1818
HCC1806	CCLE Cell Line Gene CNV Profiles	1.0	1.46649
ion channel complex	GO Cellular Component Annotations 2015	1.0	null
hiPSC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.36
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13199
OAZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55022
Adrenocortical carcinoma_ACC_TCGA-OR-A5KT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59812
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958614
ETNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84148
response to toxic substance	GO Biological Process Annotations 2015	1.0	null
PEO1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05996
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74511
CPEB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67631
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50475
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
SOX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5679
SH2D2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14153
ZNF589	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51569
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57111
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.049
Lennox-Gastaut syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00559
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84218
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF821	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.78747
MMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16545
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85599
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.90068
Perturb_3663_KD_RBM26/RBM27_SRP243927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ERMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06739
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89769
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84846
Monogenic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
action potential	GO Biological Process Annotations 2025	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16524
F11R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0751
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20436685-ST4-1	GeneSigDB Published Gene Signatures	1.0	null
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3493
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05497
Cardiac Purkinje cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.633
KLHL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87587
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PPIP5K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71387
INO80E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97589
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7769
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30698
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
KLF4-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-133a	TargetScan Predicted Conserved microRNA Targets	1.0	0.02226
STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
brugada	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
voltage-gated channel activity	GO Molecular Function Annotations 2015	1.0	null
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.837294
Edema	CTD Gene-Disease Associations	1.0	1.14781
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.626
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	1.0	0.839353
Corticospinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
Long QT syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.36511
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
TUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56784
hsa-miR-1827	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WM983B	CCLE Cell Line Gene CNV Profiles	-1.0	-2.94911
Paranodal junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.541
PNMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69298
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
intermediate stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36788
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.967066
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.01247
superficial stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13418
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20042
ARID3A	ENCODE Transcription Factor Targets	1.0	null
regulation of heart contraction	GO Biological Process Annotations 2025	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WN-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
FAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97908
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
Adenocarcinoma of lung_Lung Tissue_GSE1037	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.87133
channel regulator activity	GO Molecular Function Annotations 2015	1.0	null
DNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18047
hsa-miR-4519	TargetScan Predicted Conserved microRNA Targets	1.0	0.02226
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4484
BRD-K69396470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13988
TRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4896
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37296
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01072
GTEX-V955-0926-SM-4JBJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986038
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.971
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5711
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
PMC4858740-ncomms11473-s2.xls-HAdV-D9_cr1b_Library_1-Hit_name_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
KCTD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70334
hsa-miR-4455	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
ZFP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14807
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BTBD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84212
APMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.248
hsa-miR-608	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
19658189-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72208
PHKG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4401
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Axon initial segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.799
cation channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37413
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.968843
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW684	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6377
FBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5269
PCDHB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9368
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951036
BRD-K68705041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29403
abnormal nervous system electrophysiology	MGI Mouse Phenotype Associations 2023	1.0	null
hsa-miR-4653-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
PPP1R3F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3046
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE228413_4_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLXNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7706
C7orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61877
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.929102
voltage-gated sodium channel complex	GO Cellular Component Annotations 2023	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
ZNRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82246
C9orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15602
BRD-K00972013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24777
Sympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.950616
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38798
U251	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.46172
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86252
Axon guidance	Reactome Pathways 2014	1.0	null
CAPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30982
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF485	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86183
H3K27me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40896
SKMEL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53329
RARB-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37723
ROS50	DepMap CRISPR Gene Dependency	1.0	2.20891
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25732
Adenocarcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.509
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Seizures	CTD Gene-Disease Associations	1.0	1.13143
hsa-miR-4438	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
HOS	CCLE Cell Line Gene Expression Profiles	1.0	1.49859
BRD-K01709173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27072
ZFAND2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88926
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985368
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2481
Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.92468
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5583
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6367-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.943005
pargyline-7016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53343197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06785
BRD-K24997610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26634
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.705697
Lung squamous cell carcinoma_LUSC_TCGA-85-6175-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Sick Sinus Syndrome	DisGeNET Gene-Disease Associations	1.0	null
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-2.32987
GYG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83873
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of transmembrane transporter activity	GO Biological Process Annotations 2015	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2275
DNAJB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60007
BRD-K65445351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86555
ZNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56121
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05627
inner SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.91073
esophagus	HPA Tissue Protein Expression Profiles	1.0	0.828035
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
myricetin-4090	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Lung adenocarcinoma_LUAD_TCGA-49-6743-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U138MG	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02727
U87MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7406
TCF3	ChEA Transcription Factor Targets	1.0	null
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7A-Table_S7A_Hippocampal_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18262
chloroxylenol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42883
Familial episodic pain syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38407
BRD-K78886448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34619
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.715
hsa-miR-4319	TargetScan Predicted Conserved microRNA Targets	1.0	0.029271
cell surface	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.50879
SLC7A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77075
Cardiovascular system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
SPRED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54638
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02469
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.38511
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21536
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950352
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN013_HEPG2_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17916
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.564
ZBTB49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58739
Cardiac Conduction Defect	DisGeNET Gene-Disease Associations	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC22A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70571
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86074
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
BRD-K35923751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20526
TMEM60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89422
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4862-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82427
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953617
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-Metabric_Sparse_KM_976-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
MTCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29368
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01622
idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.14136
Nucleus y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12042
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054396
MYEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94728
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32731
ATP5MC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88087
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.853275
flunixin-2552	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Myosin XVI complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.262
SLC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55642
HUPT4	DepMap CRISPR Gene Dependency	1.0	3.43071
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Rectum adenocarcinoma_READ_TCGA-AH-6643-11A-01R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06688
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58827
DPPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54405
JAK2_activemutant_178_GSE44961	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77554
Familial episodic pain syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
PPIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11997
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3484
central lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1719
BRD-K96170115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3792
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62615
TANGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00308
heart muscle	HPA Tissue Gene Expression Profiles	1.0	1.25993
AKT1_Activation - 2 week induction_GDS2308_717_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Nodal Rhythm Disorder	DisGeNET Gene-Phenotype Associations	1.0	null
GSE161184_0_v_1_tlr7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
voltage-gated sodium channel complex	GO Cellular Component Annotations 2025	1.0	null
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887348
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.48575
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MLX_TESTES_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52899
ISL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31339
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MSS51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72621
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6264
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
18989386-Table2	GeneSigDB Published Gene Signatures	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02679
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.27798
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843075
salivary gland	HPA Tissue Protein Expression Profiles	1.0	0.828035
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ERMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79057
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lobules IV-V, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55426
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.925824
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ParietalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.859239
FUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87164
Facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13338
benserazide-6482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3475
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal seizure response to inducing agent	MPO Gene-Phenotype Associations	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04515
MPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9112
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33156
cardiac conduction	GO Biological Process Annotations 2023	1.0	null
Heart conduction disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
BRD-K71755056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48536
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71131
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948108
BRD-K50596260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31942
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	1.05775
Myotonia congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.305
GTEX-PLZ4-1326-SM-2S1O7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38407
GSTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87093
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.90865
CYP27B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50567
MFE296	CCLE Cell Line Gene Expression Profiles	1.0	2.25277
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32755
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86071
GPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7969
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.887844
MYLA	DepMap CRISPR Gene Dependency	1.0	2.76945
Perturb_8535_KD_Rbfox1/Rbfox3_SRP062242	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.8105
RPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19015
MTFP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46388
cardiovascular system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24329
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27985
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	1.0	0.855706
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
TIGD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28552
U266B1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90525
mRNA_DPPA5A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QEL4-0008-SM-447AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933706
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14538
ROGDI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28944
layer 1 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01163
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21046
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06911479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72375
SNB75	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.933909
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40711
horizontal nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28545
BRD-K38998914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03987
PGC1alpha_DEPLETION_GDS4989_283_human_A375P melanoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5483-11A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85236
BRD-K43634429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07963
Long QT Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
EPHA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2036
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11677
mRNA_ZFP42_19618472	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.62455
Timothy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
Calu-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
SHROOM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14531
ALG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58974
Necrosis	CTD Gene-Disease Associations	1.0	1.38441
abnormality of the fundus	GWASdb SNP-Phenotype Associations	1.0	0.249542
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
biological_process	GO Biological Process Annotations 2015	1.0	null
IDE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82469
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3929
CTBP2	ENCODE Transcription Factor Targets	1.0	null
PUS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83635
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.40209
channel activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
OTULIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99736
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.971179
BRD-K36096526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20316
third-degree atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
BRD-K69453385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45167
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-11A-21R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87088675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30861
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.97917
AUTS2-25519132-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZH-0926-SM-48TBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874735
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15617
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5631-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828041
polymorph layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11677
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4339
BRD-K39013648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05388
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946561
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29067
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-SI-AA8C-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
GSE173873_5_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00044
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NUDUL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51272
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38056
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0162
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956167
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59445
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876205
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2413
CCDC93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.72687
SUPT20H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74017
GSE241036_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.930493
BRD-K05475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22878
Sensory Perception	Reactome Pathways 2024	1.0	null
HSPG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3176
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03221
r3 part of spinal trigeminal sensory column, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81389
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.828035
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM86B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53277
NCIH929	CCLE Cell Line Gene CNV Profiles	1.0	1.6578
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973809
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
transporter complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30946
mRNA_ZFAND3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10794847-mmc2.xlsx-PBRM1_KD_down-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96434
19505326-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08478
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5828
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.07241
LIVF001-025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07196
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
NEK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24526
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE115363_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hippocampal mossy fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
abnormality of the globe	GWASdb SNP-Phenotype Associations	1.0	0.160272
hsa-miR-668	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09363
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.176319
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59T-01A-21R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Valproic Acid	DrugBank Drug Targets	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.039
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lobules IV-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3174
Ectopic Rhythm	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.08372
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358174
STX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20375
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870389
cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4749-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
POU5F1	ChEA Transcription Factor Targets	1.0	null
lactobionic acid-6605	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.994225
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37356
Vagus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.223
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2716-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5086
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-34a	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
786O	CCLE Cell Line Gene Expression Profiles	1.0	1.42553
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
all	GWASdb SNP-Phenotype Associations	1.0	0.052339
BRD-K91654198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02203
SFSWAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43299
hsa-miR-4273	TargetScan Predicted Conserved microRNA Targets	1.0	0.078844
BRD-A98888138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98657
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855699
LS411N	DepMap CRISPR Gene Dependency	1.0	2.85815
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.47755
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2166
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.424
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06179
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22645
NAXE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85341
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.885481
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971852
SNAPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55154
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14136
axons	GeneRIF Biological Term Annotations	1.0	null
HCC44	DepMap CRISPR Gene Dependency	1.0	2.64031
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12859
regulation of transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931427
chr11_118180295_T_C_b38	GTEx eQTL 2025	1.0	3.82706
GSE152637_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994866
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.998564
BRD-A63759745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1276
Perturb_8554_KD_Tet3_SRP056501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
IOMMLEE	CCLE Cell Line Gene Expression Profiles	1.0	1.6674
ZNF781	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87941
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
CDK11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19507
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHSY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47385
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0699
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977487
Synaptic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.257
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13102
GOLGA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38285
GSE149760_3_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
down syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.215992
Atherosclerosis_Aorta Smooth Muscle Tissue_GSE1560	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.37002
Cardiomyopathy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K69775722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11831
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29177
hsa-miR-4732-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.004732
FAM168A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79749
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.996226
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09363
GAPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39396
CRCGN016_MCF10A.TP53.M_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34846
ASXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23051
RSC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86179
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10247
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.7109
regulation of metal ion transport	GO Biological Process Annotations 2015	1.0	null
SOX3-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4667-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62177
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.02775
NXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36633
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUDHL5	CCLE Cell Line Gene CNV Profiles	1.0	1.85322
Developmental and epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.149
RERFLCAD1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70119
CFAP157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48509
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950331
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95531
TIA1_KO_GSE54418_261_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34995
Developmental and epileptic encephalopathy 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
GTEX-SN8G-0226-SM-4DM6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890323
FOXH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04543
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.00313
143B	CCLE Cell Line Gene CNV Profiles	1.0	1.93331
St Segment Elevation (Finding)	DisGeNET Gene-Phenotype Associations	1.0	null
regulation of atrial cardiac muscle cell membrane depolarization	GO Biological Process Annotations 2023	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2275
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5406
BRD-K25989885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15093
BRD-K45358881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03708
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53494
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28812
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51091
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
abnormality of bone marrow cell morphology	GWASdb SNP-Phenotype Associations	1.0	0.270044
hsa-miR-4723-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CLDN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61987
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25004
Sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.672
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23033
NXPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70347
hsa-miR-4795-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.09881
ZNF469	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9927
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24745
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57388
BRD-K00797068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33303
MED11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47356
Axon guidance	Reactome Pathways 2024	1.0	null
Immunoglobulin-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.06987
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5545-01A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
axon initial segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.633732
UBE2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39395
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-U4B1-0526-SM-4DXTK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900909
HCC366	CCLE Cell Line Gene CNV Profiles	1.0	1.84031
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985092
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.7109
YTHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42438
Superior olivary complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19229
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06642
hsa-miR-663b	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
VLDLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29826
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.25931
foxa2_20483781_p15_lung_lof_mouse_gpl1261_gse19204	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.032896
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-371b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
RGP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83904
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5576-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Atrial fibrillation	ClinVar Gene-Phenotype Associations 2025	1.0	null
JADE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70116
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4716
VCPKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84921
Brugada Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38206
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-208a	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
BRD-K35035851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39347
AKT1_OE_GDS2308[_473_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
magnocellular diagonal band nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27046
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13893
regulation of sodium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
NOCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07674
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.825173
transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.009294
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16134
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6155
AIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34547
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42311
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.980358
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876572
CTCF_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RGMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37002
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.454019
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	0.828035
artery disease	GWASdb SNP-Disease Associations	1.0	0.093546
nd7/23	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
MPZL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71229
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64813
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Medial pterygoid muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
NPTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78
BRD-A64957606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72656
BRD-K67131822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70436
Lateral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44087
GTEX-OOBK-0226-SM-2YUMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
CARF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47477
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NH12	DepMap CRISPR Gene Dependency	1.0	18.9456
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE249714_0_v_1_anxa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27559
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861031
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57554
SMAD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59115
TCF3-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCIH854	CCLE Cell Line Gene Expression Profiles	1.0	1.5918
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65203256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15301
hsa-miR-106b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
SKG-IIIa	GDSC Cell Line Gene Expression Profiles	-1.0	-1.93978
lymphnode_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38407
VOPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23298
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94971
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56182
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-451b	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SALL4	ChEA Transcription Factor Targets	1.0	null
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23342
RAGE_knockout_267_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.46909
BRD-K29642620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16003
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01325
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.063895
PKP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49678
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	GO Molecular Function Annotations 2015	1.0	null
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K65796649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21713
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975651
superficial stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61075
GSE243491_3_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83902
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046507
TINAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92033
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	1.15612
heart conduction disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55125
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87889654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.081
CEBPB_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.2418
hsa-miR-3183	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MIGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43891
REXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.087
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
regulation of monoatomic ion transmembrane transporter activity	GO Biological Process Annotations 2023	1.0	null
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.2577
ZNF180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87332
SLC16A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04865
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.90528
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02597
ZFAND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60405
abnormality of the retina	GWASdb SNP-Phenotype Associations	1.0	1.05775
BRD-K72800151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00951
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842668
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52507
Lung squamous cell carcinoma_LUSC_TCGA-90-7767-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.64507
GSE205976,GSE205978_3_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03412
Cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.952
RAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64977
Perturb_5523_KD_Apoa4_SRP393880	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.5438
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
BRD-K39411863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14344
NUDT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68578
Primary motor area, Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05051
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985663
cardiac muscle cell contraction	GO Biological Process Annotations 2023	1.0	null
YIPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2497
CTSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67338
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37236
KDM4A	ENCODE Transcription Factor Targets	1.0	null
BRD-K56250581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4358
Long QT syndrome 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842978
FLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74121
sensory peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.58433
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Long QT syndrome 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
BRD-K27723822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27826
Myocarditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
C5orf15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12092
BRD-K19712135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46154
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55568
hsa-miR-410	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
mRNA_SALL4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59391
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48169
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06931
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
TE-11	GDSC Cell Line Gene Expression Profiles	1.0	1.96926
Long QT syndrome 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
CA46	CCLE Cell Line Gene Expression Profiles	1.0	1.7532
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55623
stomach	HPA Tissue Protein Expression Profiles	1.0	0.828035
hsa-miR-3120-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.099701
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.9366
SPACA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04052
SLC30A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85873
hsa-miR-762	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22831
CXCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44312
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HNF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36517
15273739-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89171
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06289
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22779
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3012
ZFYVE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6671
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33551
HOOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78071
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58634
CEBPB	ENCODE Transcription Factor Targets	1.0	null
abnormality of the posterior segment of the eye	GWASdb SNP-Phenotype Associations	1.0	0.249542
SLC38A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31017
r2 part of superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09749
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32509
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.56387
BRD-K37774987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09178
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04547
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.828035
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OAW28	CCLE Cell Line Gene Expression Profiles	1.0	1.75291
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52495
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of membrane depolarization	GO Biological Process Annotations 2023	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00205
GSE125153_2_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96325
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Intralaminar nuclei of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28545
IDI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52126
abnormal nervous system electrophysiology	MPO Gene-Phenotype Associations	1.0	null
Atrial Fibrillation	HuGE Navigator Gene-Phenotype Associations	1.0	null
ZM-226600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51186
GTEX-RUSQ-0126-SM-47JWV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31392
BRD-K10704442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13732
QRICH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27235
BRD-K49866832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31016
ATF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45564
Sudden Infant Death	HuGE Navigator Gene-Phenotype Associations	1.0	null
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18656
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61348
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2969
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47562
LIVF001-009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2311
SUDHL5	CCLE Cell Line Gene Expression Profiles	1.0	1.94836
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09426
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1555
ZBTB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31552
Spinal nucleus of the trigeminal, oral part, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40882
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875781
CRCGN016_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19421
MHH-NB-11	GDSC Cell Line Gene Expression Profiles	-1.0	-1.76512
tretinoin_mus musculus_gpl1261_gds4294	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05974
BRD-K43789905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85075
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16168
regulation of ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10713402-aging-15-205220-s005.docx-0-RBAK_RBAK	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10731
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
sodium ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
S1PR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83103
MKN1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69023
SUGP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89408
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75402
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.37711
GTEX-Q2AH-0226-SM-48U1I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935783
BRD-K89719122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22637
FOXP2	ChEA Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49431
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00984
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF543	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.43003
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
mediodorsal nucleus of thalamus_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913124
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03768
S1PR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35939
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GSE165579_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10859
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
U937	CCLE Cell Line Gene Expression Profiles	1.0	1.54242
BRD-K48813201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64086
Perturb_8534_KD_Rbfox1/Rbfox3_SRP062242	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.699
FGF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17104
hsa-miR-133b	TargetScan Predicted Conserved microRNA Targets	1.0	0.02226
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Perturb_8537_KO_Notch2_SRP152804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Myelin P0 protein related	InterPro Predicted Protein Domain Annotations	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888422
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.32697
gliclazide-5089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Episodic ataxia type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
BRD-K71213946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54962
SETSIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0208
Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50400833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42052
PSMD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24113
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980637
BRD-K25757224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59917
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08497
cell communication	GO Biological Process Annotations 2015	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10177
BRD-K04969760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40609
transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.009393
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TV-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHCHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40937
cellular process	GO Biological Process Annotations 2015	1.0	null
CDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48134
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
CALHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11888
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864809
candidate	GeneRIF Biological Term Annotations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_108_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01995
striated muscle contraction	GO Biological Process Annotations 2023	1.0	null
BRD-K90759274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1122
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1387
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855476
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-3M cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
regulation of system process	GO Biological Process Annotations 2015	1.0	null
ramifenazone-6097	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UJMC-0426-SM-4IHJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173873_12_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92511
protein complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872712
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09411
Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31841
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PRKCA_knockdown_118_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.12857
increased heart left ventricle size	IMPC Knockout Mouse Phenotypes	1.0	null
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.2866
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17202
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06179
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96879
Childhood absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.967478
NCI-H510 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
GPX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56446
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29844
hsa-miR-548o	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
methazolamide-2733	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
hsa-miR-765	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
AIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14429
Perturb_3664_KD_RBM27_SRP243927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
ZNF263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6273
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
colchicine-3213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10878
INAVA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80292
MTMR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73603
GSE158743_1_v_2_nfkbia_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27631
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PDE6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48694
GSE196540,GSE196542_4_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FBXL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83599
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44618
ZNF330	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17699
FERMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00358
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
psgammasecretase	GeneRIF Biological Term Annotations	1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832957
GRIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8276
GAS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77188
Sudden infant death syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.311
NCI-H146 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
Neurogenic Muscular Atrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2566	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.04845
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63759
CES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37544
CCZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75498
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H6-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41942
SLC25A30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89666
CORL279	DepMap CRISPR Gene Dependency	1.0	2.30243
hsa-miR-3691-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
SUCLG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7033
SCC4	DepMap CRISPR Gene Dependency	1.0	2.72907
PTPRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04314
PTGFRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26532
GTEX-XUJ4-2426-SM-4BOO3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843919
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30974
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.36
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01081
KCNJ11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24272
cochlear nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04384
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09363
hsa-miR-3617	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
TFAP2A-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PRSS22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97131
Sarcoma_SARC_TCGA-FX-A3NJ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20713
CCDC124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48373
BRD-K55584718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11107
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72507
hsa-miR-1273f	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
LARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45171
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878314
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-5155-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045261
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949424
BRD-K60460300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26965
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ataxia	CTD Gene-Disease Associations	1.0	1.07128
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74179
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997265
GSE111245_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM109	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33455
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73669
voltage-gated sodium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
DMRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83248
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03446
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.930431
ARHGEF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48697
PCDHB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76513
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36015
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37575
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
ARHGEF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30083
BRD-K68915174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82332
LSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39569
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20W-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
PRR14L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83665
NOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7732
EIF4E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94369
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MGAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5328
Lung non-small cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.538
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15116
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8142
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S33H-0008-SM-4AD6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949261
Lung adenocarcinoma_LUAD_TCGA-55-8614-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923688
hsa-miR-3152-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K88943141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85696
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9336
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863072
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044916
Gmeb1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.8416
UGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98975
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RGS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.03144
generalized epilepsy with febrile seizures plus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.838476
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93082
BRD-K10987837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58709
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
mRNA_AES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
eye disease	GWASdb SNP-Disease Associations	1.0	0.162079
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.433
NMCG1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76368
Inward rectifier potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.076
hsa-miR-486-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
Long QT syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.64
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Atrial fibrillation, familial, 14	ClinVar Gene-Phenotype Associations	1.0	null
Perturb_2270_KO_lincBrn1b_SRP028547	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5394
rectum	HPA Tissue Protein Expression Profiles	1.0	0.828035
First Degree Atrioventricular Block	DisGeNET Gene-Disease Associations	1.0	null
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869027
CHP126	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67993
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2655
MYCN	ChEA Transcription Factor Targets	1.0	null
HUG1N	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45146
BRD-K28135985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46042
FBXO34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85773
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.886
ZBTB44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83191
H3K27me3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cadaver	HuGE Navigator Gene-Phenotype Associations	1.0	null
MKX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03541
lateral (parvicellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35066
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.98239
BAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77792
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.52745
ASPRV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52734
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95716
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.56479
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4511
BRD-K61795707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26629
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38902
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ST6GAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81878
hsa-miR-4695-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
DHRS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60279
hsa-miR-1207-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
superficial stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28545
GSE110178_4_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08375
RCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44917
Long QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.626
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08385
positive regulation of sodium ion transport	GO Biological Process Annotations 2025	1.0	null
Plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.990908
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atrial fibrillation, familial, 14	OMIM Gene-Disease Associations	1.0	null
Exocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.255
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.22945
methoxamine-6627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nerve	GeneRIF Biological Term Annotations	1.0	null
CEP131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20703
BRD-K95558029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50469
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
Paroxysmal Ventricular Tachycardia	DisGeNET Gene-Disease Associations	1.0	null
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.693391
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10193
PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884916
hsa-miR-106a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66761
MTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39511
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inorganic cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906356
BRD-K53725468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4772
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00414849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35864
CNPY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42252
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.437
PMC12297505-41598_2025_11704_MOESM4_ESM.xlsx-table_s4_veen-GSE16011_AND_TCGA-GBMLGG_NOT_Human_kinases_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBED-0726-SM-4GIAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1411
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	3.20118
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Developmental Biology	Reactome Pathways 2014	1.0	null
Childhood electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
Uterine Carcinosarcoma_UCS_TCGA-NF-A4WX-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.939084
JUND	ENCODE Transcription Factor Targets	1.0	null
ZSCAN22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79973
single-organism process	GO Biological Process Annotations 2015	1.0	null
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06257
Trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00538
clomifene-4994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.46838
Glutamatergic postsynaptic density	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.992
EDNRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1381
hsa-miR-1915	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
L1CAM interactions	Reactome Pathways 2024	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38407
clobetasol-6835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Interaction between L1 and Ankyrins	Reactome Pathways 2014	1.0	null
GPR63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92711
FGFR3_knockdown_174_GSE41035	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.76438
transmembrane transporter complex	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-4492	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
TMSB15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01922
UMRC7	DepMap CRISPR Gene Dependency	1.0	2.22803
oval paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27046
Sodium	CTD Gene-Chemical Interactions	1.0	null
regulation of transport	GO Biological Process Annotations 2015	1.0	null
Transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.037
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926886
Arrhythmogenic right ventricular cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.985
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.106731
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8642_KD_Tet3_SRP056501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
YH13	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65742
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864325
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
PNPLA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48006
CCND1	ChEA Transcription Factor Targets	1.0	null
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882834
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986639
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.874
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990935
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OX-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890739
22RV1	DepMap CRISPR Gene Dependency	1.0	3.11478
BRD-K69740275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3749
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08932
Perturb_16533_KO_Cdk8_SRP351257	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.5564
SKNAS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41372
Phospholamban complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.889
FOS	ENCODE Transcription Factor Targets	1.0	null
KYSE-70	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45132
chlorpropamide-3210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94540403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28612
hsa-miR-135a	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06565
GSE205163,GSE205164_5_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00494
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29106
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00649
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.072202
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
Culmen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3174
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14305
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79284
BRD-K78288885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0839
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.433
Tetrodotoxin	CTD Gene-Chemical Interactions	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.957664
Ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_114_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
HIV_Infected-mDC_None_GSE42058	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.78378
GSE112761,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.57788
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KATOIII	CCLE Cell Line Gene CNV Profiles	1.0	1.46428
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890275
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26813
FBXW5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.152
cardiac muscle contraction	GO Biological Process Annotations 2015	1.0	null
BRD-K46603043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37296
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.009414
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Interventricular septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
Acute Myeloid Leukemia_LAML_TCGA-AB-2825-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-135b	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
Dystrobrevin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.896
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97458
Zonisamide	HMDB Metabolites of Enzymes	1.0	null
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LRWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58624
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4692	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
SRSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11042
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69726
STAT3	ENCODE Transcription Factor Targets	1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31423
EJM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE151494_10_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.34678
TOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0421
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54072
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0S7-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.459
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08892
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8902
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50297
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4531	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.92819
anterior pretectal nucleus, dorsal core part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36788
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13647
TC71	CCLE Cell Line Gene Expression Profiles	1.0	1.6776
regulation of blood circulation	GO Biological Process Annotations 2015	1.0	null
MFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01212
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843283
layer 1 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00582
muscle system process	GO Biological Process Annotations 2015	1.0	null
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14369
KIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.91674
mediated	GeneRIF Biological Term Annotations	1.0	null
ZNF792	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60296
regulation of heart contraction	GO Biological Process Annotations 2015	1.0	null
GSE173873_8_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47628
BRD-A83387524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02195
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.137278
Lobule II, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00097
BRD-K75626008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15046
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844114
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14933
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.90335
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
SMARCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88841
CMLT1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44609
Atrioventricular node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.46
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96673
DR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66949
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
fluoxetine_mus musculus_gpl1261_gse35763	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
15374961-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1999
STEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79738
MC116	CCLE Cell Line Gene Expression Profiles	1.0	1.68832
BRD-K59386816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2959
PL18	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.2703
RCOR1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5154
Generalized epilepsy with febrile seizures plus 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.933
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.982
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01001
DIABLO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2478
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Cardiac muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.931
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41507
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.948108
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12899
beta2	GeneRIF Biological Term Annotations	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829617
hsa-miR-4700-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Familial periodic paralysis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
metal ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
CALCOCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39741
Perturb_15770_KO_Uxt_SRP240277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
15902281-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-93	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K01853388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3026
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052007
GSE112762,GSE112767_1_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JRA - Juvenile rheumatoid arthritis_Peripheral blood mononuclear cell_GSE7753	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.40697
voltage-gated sodium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99858
19269367-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Trifascicular Block	DisGeNET Gene-Disease Associations	1.0	null
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Perturb_16956_Mut_Kif1b_SRP094648	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.0758
Av Block First Degree By Ecg Finding	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K05463922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32387
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.462626
cefixime-4390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Supraventricular Tachycardia	DisGeNET Gene-Disease Associations	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
sodium ion transport	GO Biological Process Annotations 2015	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42887
ZC3H10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76665
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A81392774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03584
regulation of homeostatic process	GO Biological Process Annotations 2015	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41335
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.588431
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55587
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.363393
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23533
FGFR3_knockdown_173_GSE41035	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.09164
Intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
FGFR3_knockdown_34_GDS4454	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.09169
TNNC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52374
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37195
Pulmonary vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.381
Dravet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.103
TAS2R5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88722
monovalent inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
DYRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15694
striated muscle contraction	GO Biological Process Annotations 2025	1.0	null
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
MYO9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46695
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56221
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.566054
RHOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90131
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.848233
EIF4EBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82517
DB	CCLE Cell Line Gene Expression Profiles	1.0	1.47076
BRD-K64264170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03086
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29035
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913725
Zonisamide	DrugBank Drug Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Charcot-Marie-Tooth Disease	DisGeNET Gene-Disease Associations	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1137
BRD-K00717406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18941
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15863
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.979378
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5158
USP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07256
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.731