association dataset threshold value standardized value cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.318635 PMC4684962__F5 PFOCR Pathway Figure Associations 2023 1.0 null E2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8562 CRCGN012_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.03248 BRD-K86232198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32833 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-T6MN-2626-SM-32PMQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.09809 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4714-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.58295 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null PC-14 GDSC Cell Line Gene Expression Profiles 1.0 1.4713 sensory perception of sour taste GO Biological Process Annotations 2025 1.0 null BRD-K18620798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07166 ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null cellular response to aldosterone GO Biological Process Annotations 2025 1.0 null H1-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72244 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 1.96292 LHX9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04555 BRD-K69826976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25185 TOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70828 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.995006 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00772 oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.491791 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7SE-0008-SM-33HB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97923 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.58549 integrator GeneRIF Biological Term Annotations 1.0 null GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63767 NUP188 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68355 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.895655 ventrolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.972805 BTS LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18244 TRIM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29411 ICAM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28791 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.546 neuronal GeneRIF Biological Term Annotations 1.0 null ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20041 inner CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.96077 SNU761 DepMap CRISPR Gene Dependency 1.0 3.06606 PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null TC205 DepMap CRISPR Gene Dependency 1.0 4.32666 CGB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02565 BRD-A76904477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34911 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66572611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1337 CREB3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8039 mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24887 GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.866773 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.919356 Bladder Urothelial Carcinoma_BLCA_TCGA-LT-A5Z6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.573616 EVPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15378 organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36114 PMC4684962__F5 PFOCR Pathway Figure Associations 2024 1.0 null BRD-K23196166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26387 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 2.05083 ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.31644 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSNK2A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86025 alpha GeneRIF Biological Term Annotations 1.0 null GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.30801 ZNF841 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87216 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0011-R6A-SM-46MVJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01491 BRD-K42799692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11499 Meningococcal infection_Umbilical vein_GSE4646 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -3.01537 RPL26L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20401 ARF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83908 outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05096 COV413B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09934 reflux GeneRIF Biological Term Annotations 1.0 null BRD-K60936953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17695 BRD-K95460104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8747 GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3631 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07385 large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05778 GSE238018_3_v_4_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.975371 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.85132 Mesothelioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.595 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles 1.0 1.21348 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURKAT DepMap CRISPR Gene Dependency 1.0 4.2832 FOS ENCODE Transcription Factor Targets 1.0 null PMC11551338-pnas.2411189121.sd01.xlsx-AHR-Unnamed_0_AHR Rummagene Transcription Factor Associations 2026 1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55405 GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.64125 BRD-K22069962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1651 CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.65035 GSE128730_0_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null Primary immunodeficiency disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 H3K9me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K29992178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49562 BRD-K57357304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63591 RBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77517 cytoskeleton COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 HNFA-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K28795679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.45152 BRD-K68687385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17065 GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null EAST syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.005 BRD-K48592348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13166 POU3F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4148 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.65016 BRD-K75497233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91863 Actin cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GSE217776,GSE217829_1_v_6_sgf29_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K14193598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10508 HLC1 CCLE Cell Line Gene Expression Profiles 1.0 1.90252 heart TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.219707 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05256 precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.55656 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.973204 TFEB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1566 E2F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0147 COLO201 DepMap CRISPR Gene Dependency 1.0 2.43218 KCTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0813 MAST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.174 CAMSAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07204 MYO19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46564 GSE60217_1_v_7_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null JKAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35113 protons GeneRIF Biological Term Annotations 1.0 null BRD-K76701247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65344 CRCGN009_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14044 abdominal aortic aneurysm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.204263 BRD-K66253165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51774 BRD-K25045770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52387 SLC12A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9009 rough endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.215063 Gastroesophageal Reflux Disease DisGeNET Gene-Disease Associations 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.837747 SLC30A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5682 BRD-K31851055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30837 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01722 intracellular sodium ion homeostasis GO Biological Process Annotations 2025 1.0 null SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.1647 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.44225 LAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53473 BRD-K10460649 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13994 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A80035237 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38635 lytic vacuole LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K27616003 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91033 subgenual (subcallosal) division of MFC (area 25) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.7106 sodium ion import across plasma membrane GO Biological Process Annotations 2023 1.0 null GSE128333_4_v_1_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.871649 influenza DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.217693 FLOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29663 BRD-K09117810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29641 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048158 KMS20 DepMap CRISPR Gene Dependency 1.0 2.35028 BRD-K63420290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22554 GTEX-X4XX-3026-SM-3NMB2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.968883 GSE60217_1_v_0_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04966 BRD-K84391462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13954 DCAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46887 SOX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40327 GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.14608 APEX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46298 CUL1 Pathway Commons Protein-Protein Interactions 1.0 null TAF1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.354 NDUFV2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73625 IRF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11256 HNRNPDL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11452 substrate-specific channel activity GO Molecular Function Annotations 2015 1.0 null GSE183335,GSE183351_1_v_0_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null PDE7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91809 SCNN1B Pathway Commons Protein-Protein Interactions 1.0 null MTCH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.29368 Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WNK2 Pathway Commons Protein-Protein Interactions 1.0 null cation transmembrane transport GO Biological Process Annotations 2015 1.0 null TSSC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21554 SSX2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97577 icSARA deltaORF6_24Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.13158 Abdominal obesity-metabolic syndrome 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.08518 relieving GeneRIF Biological Term Annotations 1.0 null GTEX-XLM4-3026-SM-4AT6L GTEx Tissue Sample Gene Expression Profiles 1.0 1.12578 TRIAMTERENE DGIdb Drug Targets 2026 1.0 1.96044 GPR27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5015 CCDC90B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77832 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.862739 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.88783 Neck TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC12068594-pgen.1011693.s007.xlsx-MCR_vs_MCW-gene_id_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4711-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null native GeneRIF Biological Term Annotations 1.0 null SMARCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14499 WASHC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02901 Perturb_10234_KO_FAM120A_SRP384156 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.8903 Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.89 dysentery DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.51611 PRELID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08686 BRD-K05734090 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18127 DEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78693 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K63568016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20532 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.899692 BRD-A26952628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56978 NMRAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7098 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.56748 hsa-miR-3166 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null PSMA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73528 area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.929593 DMS454 CCLE Cell Line Gene CNV Profiles 1.0 3.1015 BRD-K92794990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72704 striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.991914 GTEX-PLZ4-2826-SM-3P617 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20326 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02405 BRD-K18368161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36668 SLC7A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02931 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893907 AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.258242 Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 GTEX-Q2AH-2026-SM-2S1PX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2057 FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.1532 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26781 552-02 DGIdb Drug Targets 2026 1.0 4.411 BRD-K22970494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57018 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K83307202 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.38593 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82386 cellular response to peptide hormone stimulus GO Biological Process Annotations 2025 1.0 null DNASE1L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70781 GSE229914_1_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18 different GeneRIF Biological Term Annotations 1.0 null icSARS CoV_54Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.04753 Medullary collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.814 PMC10915192-ab-23-0304-Supplementary-Table-S6.pdf-25-FOXK2_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4341-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bone inflammation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.052424 testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 1.15209 LRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96008 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92218 Taste HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00156 HAPSTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53655 CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.08929 GTEX-R55F-0226-SM-48FCI GTEx Tissue Sample Gene Expression Profiles 1.0 0.998159 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.68336 Respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lung adenocarcinoma_LUAD_TCGA-78-8660-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rectum_8c HPA Tissue Sample Gene Expression Profiles -1.0 -1.2837 ZSCAN5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66361 plasma membrane COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 germ layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074954 glioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.121272 NUDT14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33686 GTEX-P4PP-2026-SM-3P61N GTEx Tissue Sample Gene Expression Profiles 1.0 1.00599 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857433 IPC298 DepMap CRISPR Gene Dependency 1.0 2.12883 Stress, Psychological HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03685 MOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22298 CRCGN016_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.45678 SNRNP70 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41306 BRD-K00767817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04846 glia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.096556 Airway fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.988 responsible GeneRIF Biological Term Annotations 1.0 null system GeneRIF Biological Term Annotations 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.95003 GSE216043_3_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K43390655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57342 Lithium CTD Gene-Chemical Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44622259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.04001 Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAEC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.008 Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.08745 Cortical collecting duct cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.708 Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.7676 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49749 GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03757 KREMEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36506 tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.203275 GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51392 Adult respiratory distress syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 CRCGN015_MCF10A_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.22034 FANCM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4225 NCI-H510A COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 esophagus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.08332 EIF2AK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07272 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Na+ channel, amiloride-sensitive, conserved site InterPro Predicted Protein Domain Annotations 1.0 null IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82552 17210682-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.9509 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.56493 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null JUN ENCODE Transcription Factor Targets 1.0 null BRD-K29771129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03323 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.922166 GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901393 NCI-H716 GDSC Cell Line Gene Expression Profiles 1.0 1.91503 BRD-K01377768 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06096 TMEM242 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44344 STAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32101 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.877572 GTEX-X4XX-0626-SM-3NMC1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88786 thyroid_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.05128 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null LEAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60427 NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.7354 MRPS25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26179 colonic epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.341863 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7R8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE233679_12_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.9913 BLUE1 DepMap CRISPR Gene Dependency 1.0 2.15229 Xenopus A6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.772 CFPAC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.46022 SKOV3 BioGPS Cell Line Gene Expression Profiles 1.0 0.979912 non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 zona incerta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.90518 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null substantia nigra, pars compacta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.47135 Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.555 CRCGN016_MCF10A.WT.HP_24H:J05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02293 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10197848-12885_2023_10795_MOESM5_ESM.xlsx-Sheet1-ESR2_overexpressing_MCF7_cells_ESR2 Rummagene Transcription Factor Associations 2026 1.0 null IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.824583 GTEX-XOTO-3026-SM-4B65M GTEx Tissue Sample Gene Expression Profiles 1.0 0.926529 GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32974 BRD-K40057256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47628 GSE175787_4_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-A30369394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00535 PLPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1005 CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.41165 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.931007 BRD-K73669270 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04366 adrenal gland HPA Tissue Gene Expression Profiles 1.0 1.09968 Connecting tubule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.854 HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.971977 BRD-K69274755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.21413 NB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.41516 Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.382 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906374 BRD-K83254798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08989 GGTLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63979 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cation channel complex GO Cellular Component Annotations 2023 1.0 null tongue epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.420385 POGLUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80085 VCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15045 BRD-K07979116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05351 Sensory dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.624 22RV1 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37445 GSE146982_7_v_5_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null vagina TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.517284 DPY19L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36612 transcript GeneRIF Biological Term Annotations 1.0 null GATA6-21074721-CACO-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ABHD15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40333 Autoimmune disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 BRD-K14925361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40247 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22775 GNAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20104 cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.43259 H9 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K00263786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30492 macromolecular complex COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 ventromedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1957 GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.27781 UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-Q2AG-0011-R11A-SM-2HMKZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.19792 internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59712 possibly GeneRIF Biological Term Annotations 1.0 null colonrectum_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.963691 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null sensory perception of chemical stimulus GO Biological Process Annotations 2015 1.0 null NCI-H1755 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17595 mesothelioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.601686 FOS_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80921954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27454 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.2559 inorganic cation transmembrane transport GO Biological Process Annotations 2023 1.0 null SERPINE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49886 LTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38235 TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29862 ELOVL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91424 cation-transporting ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.836 BRD-K17854062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34532 plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919943 PLA2G3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13283 ligand-gated sodium channel activity GO Molecular Function Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE235066_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55748 RBBP5 ENCODE Transcription Factor Targets 1.0 null BRD-K50946180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27027 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.310059 BRD-K82446079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23076 GSE183335,GSE183351_3_v_0_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K19575490 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01992 CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.24282 WM793 CCLE Cell Line Gene Expression Profiles -1.0 -2.21943 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K18494310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05745 BRD-K82538319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19683 PALS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39154 CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.00235 MORCPR CCLE Cell Line Gene CNV Profiles 1.0 1.63767 Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A96334094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83613 GSE85995_1_v_0_gata3_human RummaGEO Gene Perturbation Signatures 1.0 null DES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26508 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null RELA_01_30 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60326 GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.30957 inorganic ion transmembrane transport GO Biological Process Annotations 2015 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.019 STN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66008 releasing GeneRIF Biological Term Annotations 1.0 null BRD-K93516545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20153 stimulates GeneRIF Biological Term Annotations 1.0 null Cortical collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.784 CCDC74B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69408 PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.73212 AKIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7062 BRD-K70685307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.18274 SGK3 Pathway Commons Protein-Protein Interactions 1.0 null endometrium_4b HPA Tissue Sample Gene Expression Profiles 1.0 0.869776 PSRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41516 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37283718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29223 cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_153_MITF Rummagene Transcription Factor Associations 2026 1.0 null EMC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.6493 GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91083 HT144SKINFV1 DepMap CRISPR Gene Dependency 1.0 2.12592 CRCGN011_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11535 GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4389 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.992019 GSE226584,GSE226589_2_v_0_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.52018 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.98515 Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-2926-SM-2TF66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06723 Sensory perception of salty taste Reactome Pathways 2024 1.0 null USF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6501 Perturb_7505_OE_ADARB1/ILF3_SRP195616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.84461 Collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.885 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.566428 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11989 sensory perception GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9314 NR2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7541 undergoes GeneRIF Biological Term Annotations 1.0 null BRD-K29519734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.64852 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10695 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1814 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.4975 BRD-K36539857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08549 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ulcerative colitis GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 CRCGN016_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21963 TALL1 CCLE Cell Line Gene Expression Profiles 1.0 2.25699 BRD-K55835264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02375 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47O-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.73894 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null obstructive lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.076627 CMK115 DepMap CRISPR Gene Dependency 1.0 4.92917 BRD-A84764193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14509 MSN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17213 VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22196 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mesothelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.175234 PMC10794847-mmc5.xlsx-PIAS1_KD_up-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR Rummagene Transcription Factor Associations 2026 1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.970014 Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.975371 CRCGN016_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.89857 BRD-K09071517 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4049 RFX5 ENCODE Transcription Factor Targets 1.0 null pool GeneRIF Biological Term Annotations 1.0 null sodium ion homeostasis GO Biological Process Annotations 2025 1.0 null SEPHS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54732 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041456 km3 HPA Cell Line Gene Expression Profiles 1.0 1.47771 BRD-K06573818 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91941 Collagenous colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T2IS-0926-SM-4DM5B GTEx Tissue Sample Gene Expression Profiles 1.0 0.852547 Head and Neck squamous cell carcinoma_HNSC_TCGA-C9-A47Z-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49681465 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7314 GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45923 HCC2998 BioGPS Cell Line Gene Expression Profiles 1.0 1.11715 HDAC2 ENCODE Transcription Factor Targets 1.0 null PANK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99661 Henles loop TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.846 CCDC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15518 EBF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73272 THNSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47593 acute myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.211934 glial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.098076 GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures 1.0 null disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.487027 Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20428 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 SLC2A4RG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84013 GTEX-RTLS-1226-SM-46MUP GTEx Tissue Sample Gene Expression Profiles 1.0 0.959216 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.985133 mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.3507 SMPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69444 BRD-K33217094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1929 SCS214 DepMap CRISPR Gene Dependency 1.0 2.79947 ZNF311 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98915 GSE133087_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null divergent GeneRIF Biological Term Annotations 1.0 null skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062024 SKMEL1 CCLE Cell Line Gene Expression Profiles -1.0 -2.81451 VRK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68677 PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.84604 RMG-I GDSC Cell Line Gene Expression Profiles 1.0 1.81532 Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.904601 WM115 CCLE Cell Line Gene CNV Profiles -1.0 -1.59469 c-MYC_KD_GDS2526_113_human_MDA-MB-231 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7086-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26608 BRD-K10416099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0594 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.477 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17095 BRD-A05422420 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14304 sodium GeneRIF Biological Term Annotations 1.0 null PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00251 PMC10794847-mmc3.xlsx-PBRM1_KD_down-Table_S2_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_differentiation_state_Related_to_Figure_2_AR Rummagene Transcription Factor Associations 2026 1.0 null sensory perception of salty taste GO Biological Process Annotations 2023 1.0 null BRD-K06863921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23927 kinase GeneRIF Biological Term Annotations 1.0 null channels GeneRIF Biological Term Annotations 1.0 null RUNX1T1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82772 BRD-K23956044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47268 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 2.00034 BRD-K77343050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0191 ATP11C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18733 SNU2535 DepMap CRISPR Gene Dependency 1.0 2.19645 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00928 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular response to vasopressin GO Biological Process Annotations 2023 1.0 null A498 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 2.53898 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41765 HNRNPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41982 GSE188721_3_v_4_mesp1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.44649 SSR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78645 ZNF575 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29915 candidate GeneRIF Biological Term Annotations 1.0 null BRD-K06724886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27676 NCVADR RES BioGPS Cell Line Gene Expression Profiles 1.0 1.22668 NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.7943 ANP32B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33643 PMC7017485__F4 PFOCR Pathway Figure Associations 2023 1.0 null BRD-K82784817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23669 BRD-K34851865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06228 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14169 BRD-A75607876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06114 PHETA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24276 regulated GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K97391170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87413 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.899653 counterpart GeneRIF Biological Term Annotations 1.0 null MAGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67604 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.92828 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58862 Distal arthrogryposis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 ECI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27595 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.940616 GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K02087489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39838 EDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40896 GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44941 intracellular organelle part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 BRD-K67104687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17753 CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.882994 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-1926-SM-32QOJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953201 RCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20589 MD-86-UW46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236684 GSE254649_2_v_0_cstf2_human RummaGEO Gene Perturbation Signatures 1.0 null MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.34549 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01215 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27288 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cellular response to aldehyde GO Biological Process Annotations 2023 1.0 null SP1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K34721572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97219 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null J-RT3-T3-5 GDSC Cell Line Gene Expression Profiles 1.0 2.45541 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.71586 Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ESPNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42107 CSAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86409 GSE109140_0_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE48812_4_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null RNASEH2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87559 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04338 P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K22002184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19916 GTEX-POMQ-1426-SM-3P61D GTEx Tissue Sample Gene Expression Profiles 1.0 0.916546 NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848705 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03628 hyperparathyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.213959 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01233 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25445 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955843 BRD-K31242007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15332 SGK1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K17821077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58437 VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897106 heterologous GeneRIF Biological Term Annotations 1.0 null BRD-K92374432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12627 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00835 BRD-K62909976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5695 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.887649 ELF1 ENCODE Transcription Factor Targets 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.437972 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2535 variant GeneRIF Biological Term Annotations 1.0 null CRY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94589 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MLX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3323 CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.40825 mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11466 KD DepMap CRISPR Gene Dependency 1.0 2.32778 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25207 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.83989 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99555 interactions GeneRIF Biological Term Annotations 1.0 null GTF2I CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11252 H3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55374 Tongue epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.089 NCI-H1915 COSMIC Cell Line Gene Mutation Profiles 1.0 null SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953634 SNU478 CCLE Cell Line Gene Expression Profiles -1.0 -1.58722 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.381379 orbital frontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22807 GTEX-XPVG-2826-SM-4B66J GTEx Tissue Sample Gene Expression Profiles 1.0 0.918781 FLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74121 CLDN15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33314 peripheral vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.128379 IFFO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11203 locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91045 BRD-K93357133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.02045 E2A MotifMap Predicted Transcription Factor Targets 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65002 GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles 1.0 1.22166 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K98109987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54383 NCI-H522 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZBTB49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58739 PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_3_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.98714 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 eye and adnexa disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044525 CNPPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52577 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K42789863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14612 abdominal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.221061 substrate-specific transporter activity GO Molecular Function Annotations 2015 1.0 null response to aldosterone GO Biological Process Annotations 2025 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null BRD-K84517695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03035 PMC3930188-813067.f1.pdf-124-SATB1_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K58971526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27336 ZNF711 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91274 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05862 BABAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34556 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8954 at1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.59 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19944 EB1 CCLE Cell Line Gene Expression Profiles 1.0 1.50815 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18909 GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.24969 Acute Myeloid Leukemia_LAML_TCGA-AB-2928-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68495784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12035 BRD-K34531548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46909 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.975371 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null HCC33 CCLE Cell Line Gene CNV Profiles -1.0 -1.88693 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.966659 intracellular organelle GO Cellular Component Annotations 2015 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20678 BRD-K18573205 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29715 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04138 GSE228263_0_v_1_elesclomol_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 TFEC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7355 Na+ channel, amiloride-sensitive InterPro Predicted Protein Domain Annotations 1.0 null A172 BioGPS Cell Line Gene Expression Profiles -1.0 -1.24075 LIMK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97895 BRD-K61432982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51229 OGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61438 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64843 BRD-K45947503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71148 Lung squamous cell carcinoma_LUSC_TCGA-O2-A52N-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inflammatory bowel disease GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.669897 EZH2 ENCODE Transcription Factor Targets 1.0 null layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.951745 SEKI DepMap CRISPR Gene Dependency 1.0 2.68801 GTEX-WFG7-0726-SM-3GIKO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852144 SNU1272 CCLE Cell Line Gene CNV Profiles -1.0 -1.36425 PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null JOSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17368 NLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83655 cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.462394 adult TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.447192 GM97 BioGPS Cell Line Gene Expression Profiles 1.0 1.3898 GSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24178 KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06351 Basolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.678 SFMBT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1161 P68-20966046-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POU5F1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1389 TUBB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7536 icSARS CoV_36Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.661283 BRD-K30530468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26662 Renal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.651 ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1267 membrane part GO Cellular Component Annotations 2015 1.0 null VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07836 HYAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83573 KCNG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58748 BRD-K44427106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09949 ZNF883 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73163 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG8-0726-SM-3GILP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35395 BRD-K16554464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03304 PAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60924 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.904995 inorganic cation transmembrane transport GO Biological Process Annotations 2025 1.0 null Stimuli-sensing channels Reactome Pathways 2014 1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1867 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1704 BRD-K18435317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36323 GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.67319 GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.854064 SP1_02_67 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58804 Cervicovaginal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.761 BRD-K56881825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26606 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.11 inorganic cation transmembrane transport GO Biological Process Annotations 2015 1.0 null stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.73408 gastrointestinal GeneRIF Biological Term Annotations 1.0 null SLC35E2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99882 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K32259584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0486 BRD-K48448518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.00011 FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.82391 GTEX-N7MT-1226-SM-2D7W4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43652 SPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48728 CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.03729 TRIM62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36938 primary auditory cortex (core)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.909466 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.28295 GTEX-RTLS-2326-SM-46MUH GTEx Tissue Sample Gene Expression Profiles 1.0 1.17645 respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K02093145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17231 GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27659 BRD-K64317740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56314 cellular response to vasopressin GO Biological Process Annotations 2025 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.14501 CRCGN012_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16589 GTEX-NPJ8-1526-SM-2D7VU GTEx Tissue Sample Gene Expression Profiles 1.0 0.855163 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Autosomal recessive pseudohypoaldosteronism type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.65 YAPC CCLE Cell Line Gene Expression Profiles -1.0 -1.54003 CRCGN016_MCF10A.TP53.M_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13244 BRD-K35193502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11572 BRD-K68665079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26947 BRD-K14695590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12462 CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE224004,GSE224005_0_v_1_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null RNF187 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70543 BRD-K10705624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88916 BRD-K70315531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05169 Bartter disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 GTEX-QDVN-0326-SM-2I3FS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918521 ESYT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56454 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.53996 GTEX-UTHO-2726-SM-4JBH9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07838 CAAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32176 binding GO Molecular Function Annotations 2015 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null Inner medullary collecting duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.763 ae2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.905 SLC16A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51562 Sweat gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.177 BRD-K33606963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13198 LCLC103H CCLE Cell Line Gene Expression Profiles -1.0 -2.3627 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.342233 MCAS COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 2.38757 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.9693 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49448 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02405 BRD-K42558179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02133 CRCGN017_MCF10A.WT.HP_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04115 GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41822 BRD-K90284572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11587 CRCGN017_MCF10A.WT.HP_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7108 intracellular GeneRIF Biological Term Annotations 1.0 null Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-XMD1-0526-SM-4AT4Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.0447 BRD-K77820593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93833 GTEX-XLM4-0011-R10A-SM-4AT5P GTEx Tissue Sample Gene Expression Profiles 1.0 0.936848 H2AB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14457 BL70 CCLE Cell Line Gene Expression Profiles 1.0 1.40551 DMS-114 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H2722 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09869 PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_bone_marrow_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null eipa GeneRIF Biological Term Annotations 1.0 null ANAPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20518 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27167 CRCGN015_MCF10A.TP53.M_24H:L21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.336 GSE233679_6_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null BAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45143 BRD-A93436351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55835 JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.95711 BRD-K40206099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21681 FZD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52973 SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 2.47617 GSE128730_0_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null Apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.968 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.268 BRD-K30145193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06041 GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946962 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.18413 BRD-K07035171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10838 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 AKT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73399 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.048 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6656 SUDHL10 DepMap CRISPR Gene Dependency 1.0 2.39878 THEM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88385 DDX28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77944 hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.68166 MYC-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-1343 TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 hsa-miR-764 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 2.37669 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null UPF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06883 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29713 GSE184356_3_v_0_tfam_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K87990170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59485 BRD-K16062794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07229 KO52 CCLE Cell Line Gene CNV Profiles 1.0 1.33012 inhibition GeneRIF Biological Term Annotations 1.0 null APBB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75134 BRD-K63987422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88033 Colorectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 BRD-K13164804 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80301 EDEM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56139 UVSSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44484 BRD-A26165232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39756 FOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0189 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38089 Fumarate reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.896 NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66Y-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AMILORIDE DGIdb Drug Targets 2026 1.0 2.2055 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null JADE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61266 EIF4EBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82517 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cation channel activity GO Molecular Function Annotations 2015 1.0 null IGSF9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97917 DGKE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3781 IGFBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04802 CDX2-21074721-CACO-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K63813316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3749 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6998-01A-23R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LRRC59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5471 sensation GeneRIF Biological Term Annotations 1.0 null PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-AIRE-HIT_AIRE Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11477 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42H-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F5-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61021741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2742 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.11645 BRD-K78574327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32445 BRD-K97886487 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29724 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SS-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VTI1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94082 icSARA deltaORF6_30Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.74484 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49I-01A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01275 Salivary duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.955 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15988 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13548 GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12267 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.28 BRD-K89447678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92251 bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042871 BRD-K88538240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65605 PMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8474 ARRDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69579 BRD-K35098144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8707 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.688 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q8-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null glioblastoma multiforme cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.774834 Alveolar wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.156 KCTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93172 integral component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.1921 GSE48812_11_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16946 amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.959844 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10942 CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39203 BAZ1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46419 GSE235066_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null NHLRC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74806 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null dichlorophen LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54919 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.94067 GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75847 GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.892118 PAX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8739 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2384 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.933145 GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01843 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13617 Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K01754882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27999 protein binding GO Molecular Function Annotations 2015 1.0 null RFX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.941 RHBDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50831 BRD-A02501536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04124 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19332 Nrd1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.612 IST-SL2 COSMIC Cell Line Gene Mutation Profiles 1.0 null sodium ion transmembrane transport GO Biological Process Annotations 2023 1.0 null BRD-K60216304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19533 Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.559 MARVELD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50877 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.38635 496100333_FWM_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.07807 SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05235 PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 2.00569 GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1159 WNK4 Pathway Commons Protein-Protein Interactions 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041709 cellular process GO Biological Process Annotations 2015 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17989 NCIH446 DepMap CRISPR Gene Dependency 1.0 3.98113 BRD-K68594161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97376 GSE135030_3_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null 769-P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46451 isoforms GeneRIF Biological Term Annotations 1.0 null GSE166914_1_v_2_abemaciclib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.729 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.908425 CRCGN013_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.38435 CRCGN013_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80912 HNRNPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14907 nucleus subceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.958137 SRPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.90611 reaction GeneRIF Biological Term Annotations 1.0 null BRD-A43164341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42893 Pseudohypoaldosteronism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.568 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.979494 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.48267 BRD-K69387464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04699 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.652 PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.04785 physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.0765 posterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.897247 496100359_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01128 BRD-A85231803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24731 nuclei GeneRIF Biological Term Annotations 1.0 null ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.987535 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29958 BRD-K81522184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59112 GTEX-T6MN-2526-SM-32PMN GTEx Tissue Sample Gene Expression Profiles 1.0 1.75954 MTHFD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24669 PARP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23991 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 1.11362 KPNYS DepMap CRISPR Gene Dependency 1.0 3.0675 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3472-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91421454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.22288 NUDT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2198 techniques GeneRIF Biological Term Annotations 1.0 null HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36268 PRCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53395 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3347 HNF4A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null BRD-K62226454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.24137 GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 2.4118 GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.08819 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50G-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.415 G28T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14695 substrate-specific transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null SNU308 CCLE Cell Line Gene Expression Profiles -1.0 -1.76761 CRCGN015_HEPG2_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33838 Uterine fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.97 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23185 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.698 BRD-A12830281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84201 ARHGEF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38866 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052458 G-361 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.374 microtubule organizing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.168101 GSE233679_6_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898542 R3HDM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54425 CRCGN016_MCF10A.TP53.M_24H:P16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00233 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.82999 retinal vascular occlusion DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.440914 level GeneRIF Biological Term Annotations 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.891337 VWCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84492 CARMIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05381 Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.96922 hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31821 Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.85 GSE213588_9_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.824312 GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57931 Cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.90376 Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_11_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36655 GTEX-S7SF-2226-SM-3K2BG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82866 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12684 identify GeneRIF Biological Term Annotations 1.0 null MRPL39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17635 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066718 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.59232 MBOAT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7105 RCOR1 ENCODE Transcription Factor Targets 1.0 null gated channel activity GO Molecular Function Annotations 2015 1.0 null Telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.948677 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 1.40896 GSE114284_1_v_3_irf1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K25954314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.47553 RPL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02867 cytoskeleton GO Cellular Component Annotations 2015 1.0 null PRSS53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4176 POGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27353 BRD-K22063616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49189 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.415053 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.240776 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052488 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Miliaria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.308 gastrooesophageal GeneRIF Biological Term Annotations 1.0 null NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.831249 BRD-K37379978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32935 PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 MON DepMap CRISPR Gene Dependency 1.0 2.51119 H1 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.971876 Lung adenocarcinoma_LUAD_TCGA-44-A4SU-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47725 RORA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2472 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67502 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.852734 Plasma membrane COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 heterogeneity GeneRIF Biological Term Annotations 1.0 null OCILY19 CCLE Cell Line Gene CNV Profiles -1.0 -1.66409 skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054056 CRCGN016_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08965 BRD-K74660272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01722 icSARS CoV_72Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.05279 murr1 GeneRIF Biological Term Annotations 1.0 null BRD-A59449038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.29088 Intercalated cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.804 PMC11196642-41419_2024_6838_MOESM5_ESM.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_expressed_genes_in_RNA-seq_between_MCF7_SMAD4-KO_and_parental_groups_SMAD4 Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0548 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.6349 KLK13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60687 intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.1199 PLEKHG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57965 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.571871 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05506 sodium ion transmembrane transport GO Biological Process Annotations 2025 1.0 null Trunk TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 hsa-miR-4763-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 response to aldosterone GO Biological Process Annotations 2023 1.0 null MAGEL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63785 BRD-K10481024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34296 ZNF703 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34724 H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.436402 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_6_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14259 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles 1.0 1.74478 TIGD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18716 BRD-K33177501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16217 KCNK17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58897 hsa-miR-3198 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GPR150 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60993 Gas bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.839 RAP1GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.76571 AKT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86097 PEA1 DepMap CRISPR Gene Dependency 1.0 3.17772 Kidney Chromophobe_KICH_TCGA-KN-8428-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RVPV-0011-R5A-SM-2TF69 GTEx Tissue Sample Gene Expression Profiles 1.0 0.866977 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MLMA COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K18599462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48303 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UV-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null arthropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.059089 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.981399 sensory perception of taste GO Biological Process Annotations 2023 1.0 null NIPBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70421 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01854 LRCH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55599 FEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47126 BRD-A12822115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22099 BRD-K98408574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43266 sodium ion transport GO Biological Process Annotations 2025 1.0 null BV173 CCLE Cell Line Gene Expression Profiles 1.0 1.69893 OBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86904 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848495 GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF766 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43293 PMC12502296-40246_2025_829_MOESM3_ESM.xlsx-Supplementary_Table_6-Supplementary_Table_6_Significant_eQTLs_MR_results_between_the_expression_of_druggable_genes_and_NSCLC_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null DVL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44855 ZNF493 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25557 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.40202 FBXO33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06775 MRPS26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98974 sodium ion homeostasis GO Biological Process Annotations 2023 1.0 null SDE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8462 Principal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.664 GSE60217_1_v_2_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.33788 measles DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.663181 NCIH522 CCLE Cell Line Gene Expression Profiles 1.0 2.05421 H3K36me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K49307935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53106 BRD-K90475322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12939 BRD-K30548577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.368 ARHGEF10L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9888 PHF8-20622853-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BCORL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65478 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60051 epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.00957 TUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31405 DPYSL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85741 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.333396 BRD-A54347351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29035 CORL23 DepMap CRISPR Gene Dependency 1.0 2.70526 FOXJ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45178 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.57771 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28036 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05987 PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K96389533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.63437 GSE199204,GSE211619_4_v_6_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB1 CCLE Cell Line Gene Expression Profiles 1.0 1.36574 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.989316 B3GNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7156 FUT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66544 GTEX-WL46-0011-R1A-SM-3LK6M GTEx Tissue Sample Gene Expression Profiles 1.0 0.8914 BRD-K29713418 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9152 FUCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75458 cellular_component GO Cellular Component Annotations 2015 1.0 null BRD-A84941884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69378 JK1 CCLE Cell Line Gene Expression Profiles -1.0 -1.93195 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SOGA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66905 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.901145 Sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANKLE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81368 SLC27A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84733 CLCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72177 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47985 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.212936 Hypertension HuGE Navigator Gene-Phenotype Associations 1.0 null C1GALT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36855 cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BT549 DepMap CRISPR Gene Dependency 1.0 2.05176 Autosomal dominant pseudohypoaldosteronism type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 CRCGN017_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8429 ESYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55632 GTEX-X4XX-0011-R6B-SM-46MWP GTEx Tissue Sample Gene Expression Profiles 1.0 0.829546 GTEX-QEG4-1126-SM-2S1P7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03749 Granulomatous Disease, Chronic_Blood neutrophil_GSE935 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.12697 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.33739 TRIM27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6881 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.548971 PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF__SURVIVAL-hugo_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.064062 PSMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84611 CRCGN016_MCF10A.WT.HP_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35511 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09048 IRX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97114 GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.31533 GMFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33041 GTEX-QDVN-2326-SM-2S1PF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866022 MYBL2 ENCODE Transcription Factor Targets 1.0 null BRPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86667 NFIC_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF319 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17244 E2F6 JASPAR Predicted Transcription Factor Targets 1.0 null PCYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41208 GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990134 Forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CAPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06757 GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867711 GTEX-OIZI-0526-SM-2XCEG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861913 astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.168617 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87848 RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7919 SubthalamicNucleus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.54217 SIX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55116 cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K63892351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00148 GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836231 TINF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09194 SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15939043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28973 SUPT7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64273 Penis_Foreskin_Melanocyte_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.871424 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.89701 alveolar GeneRIF Biological Term Annotations 1.0 null coelom TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.165319 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08027 RABGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66804 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79146 HL60 BioGPS Cell Line Gene Expression Profiles -1.0 -1.70362 GSE118077_4_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.829583 ACC3 BioGPS Cell Line Gene Expression Profiles 1.0 0.907509 SKP1 Pathway Commons Protein-Protein Interactions 1.0 null response to acidic pH GO Biological Process Annotations 2023 1.0 null HS 683 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00966 golgi apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.340395 BRD-K01314849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28394 MAX::MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4762 PMC9546828-41389_2022_435_MOESM4_ESM.xlsx-Table_S3-Table_S3_Downregulated_genes_upon_ZNF148_knockdown_P_adj_0_05_Fold_change_1_5_ZNF148 Rummagene Transcription Factor Associations 2026 1.0 null NGDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13877 UFSP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6208 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Respiratory epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN014_HEPG2_3H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.31211 Lung adenocarcinoma_LUAD_TCGA-86-8668-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.16923 NCOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68897 Eggshell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.889 Perturb_286_KD_GLUD1_SRP308178 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 intracellular non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null GSE226115,GSE226116_2_v_0_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null BRD-K99971319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14334 BRD-K86961579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08394 cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K55749438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29383 CRCGN014_HEPG2_3H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6176 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3795 GBX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22331 UFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82697 ERVMER34-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82378 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31207 organelle LOCATE Predicted Protein Localization Annotations 1.0 null 496100324_FWM_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17944 SHISAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63327 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.9728 GTEX-SJXC-0326-SM-2XCFI GTEx Tissue Sample Gene Expression Profiles 1.0 0.935902 RERFGC1B CCLE Cell Line Gene CNV Profiles 1.0 2.059 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40G-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WNK1 Pathway Commons Protein-Protein Interactions 1.0 null Glioma DisGeNET Gene-Disease Associations 1.0 null voltage-gated sodium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.035 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNAJA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.37701 BRD-K33438042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28155 retinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.061455 WI38-VA13 subline 2RA cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.975 Measles Chicago-1_6Hour_16492729_GSE980 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.37982 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916633 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXP1_FOXP1 Rummagene Transcription Factor Associations 2026 1.0 null PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09204 MEPCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44463 PDZD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8817 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.75814 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null THBD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50735 BRD-K91467755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.22999 GSE48812_3_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1796 BRD-K74300740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24033 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20446 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.869198 GSU DepMap CRISPR Gene Dependency 1.0 3.81771 MYSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15671 GSE118548_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null ADI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70991 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MPHOSPH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.34697 DNAAF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68526 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25365 Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K2-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-93-A4JN-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45901 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35416 PLAGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0719 Triamterene HMDB Metabolites of Enzymes 1.0 null Ileocolitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.185 AICDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27063 ABRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22944 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20953 PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.2082 KDM5A ENCODE Transcription Factor Targets 1.0 null BRD-K39435284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12257 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.688 actin cytoskeleton GO Cellular Component Annotations 2023 1.0 null primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.860987 BRD-K23860926 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61313 Perturb_12524_KD_Linc00673_SRP212104 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-S4Q7-0008-SM-3NM8A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831958 GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 3.02911 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null Stimuli-sensing channels Reactome Pathways 2024 1.0 null inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36982 ALG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46363 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4819-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61924304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09316 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.915285 CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962182 macroglia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.080006 EVSAT DepMap CRISPR Gene Dependency 1.0 3.82342 pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24407 posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.46494 BRD-A06158172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6157 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COMMD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03588 lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.892749 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.70426 JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0112 PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892366 SMARCAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17038 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06514 Cerebellar mossy fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.688 tonsil HPA Tissue Protein Expression Profiles -1.0 -1.23922 MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.532 MSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07834 GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925101 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L8-01A-21R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21423 Respiratory mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PYCARD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73455 reducing GeneRIF Biological Term Annotations 1.0 null POU3F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3947 GA10 CCLE Cell Line Gene Expression Profiles 1.0 1.39415 colonic epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.164502 BRD-A00776891 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61255 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ovary GTEx Tissue Gene Expression Profiles 1.0 0.938953 widely GeneRIF Biological Term Annotations 1.0 null CALU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NOC2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07837 Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUN_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.12165 lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045806 RPP25L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5441 GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948693 H2AC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12369 BRD-A96183603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31429 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886244 Mineral metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.199 Supramolecular fiber COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 secondary hyperparathyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.396353 sensor GeneRIF Biological Term Annotations 1.0 null domains GeneRIF Biological Term Annotations 1.0 null BRD-K15779027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72128 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.127266 GTEX-QVUS-2826-SM-3GADB GTEx Tissue Sample Gene Expression Profiles 1.0 0.994174 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K61651560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09078 BRD-K60456515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20344 ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.7535 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null Brain ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 Ventral pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.956813 BRD-K33221810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10472 spanning component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.24424 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886806 Olfactory epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SPRY4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77503 OUMS23 CCLE Cell Line Gene Expression Profiles -1.0 -1.53081 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73494324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3278 GSE140322_3_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null TOV-112D COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K40276277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01474 GTEX-T6MN-0726-SM-32PML GTEx Tissue Sample Gene Expression Profiles 1.0 0.97721 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.33668 ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.705 GSE48812_3_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RNOR-2226-SM-2TF5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.29027 BRD-K55286508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29947 CEP57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84921 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885493 BRD-K63743653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26118 BRD-K97276563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23291 BRCA1 ENCODE Transcription Factor Targets 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -1.29548 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63183 Epithelial sodium channel InterPro Predicted Protein Domain Annotations 1.0 null other source TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.217974 Colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07755570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47207 624 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17015 PCGF4-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null support GeneRIF Biological Term Annotations 1.0 null SLC25A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76046 GSE74251_2_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6036 Perturb_12187_OE_linc00520_SRP083129 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.67411 ligand-gated sodium channel activity GO Molecular Function Annotations 2023 1.0 null BRD-K44643967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40678 ZMAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71306 NPW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53963 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 2.46854 GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 2.86589 FAM131A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47949 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A5XV-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liddle syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.683 GTEX-QESD-0626-SM-2I5G4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17356 CRCGN015_HEPG2_48H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9369 respiratory epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SNU1196 CCLE Cell Line Gene CNV Profiles 1.0 1.87371 GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867377 Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Actin filament COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 CTHRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39933 PANC1 BioGPS Cell Line Gene Expression Profiles -1.0 -0.855416 ZDBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45724 CLDN34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85901 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.94076 GTEX-QEG5-0626-SM-2S1PP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51738 EN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81174 delta GeneRIF Biological Term Annotations 1.0 null BCL7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40929 KAT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16125 transport GO Biological Process Annotations 2015 1.0 null Smell HuGE Navigator Gene-Phenotype Associations 1.0 null GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null CTAGE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34157 496100395_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.07655 A375 COSMIC Cell Line Gene Mutation Profiles 1.0 null WWP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K04731905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78646 testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 1.33884 BRD-K32195266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31611 sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19684 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90547 BRD-K70618663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28694 RPMI-2650 COSMIC Cell Line Gene Mutation Profiles 1.0 null body wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.172722 PARP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39173 molecule GeneRIF Biological Term Annotations 1.0 null GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles 1.0 0.999893 GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MCM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3853 cellular response to ketone GO Biological Process Annotations 2023 1.0 null GSE169152_3_v_4_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null IPC-298 COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 basal nucleus of meynert, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01825 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06817 B2M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41528 TWIST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32192 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07198 BRD-A82394575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32276 GTEX-WL46-0011-R6A-SM-3LK6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.83399 496100642_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.426 channel activity GO Molecular Function Annotations 2015 1.0 null primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00232 hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.945593 COPG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92505 GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934421 BRD-K16207499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62906 GSE233112_2_v_3_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27555 activated GeneRIF Biological Term Annotations 1.0 null PTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19473 enac GeneRIF Biological Term Annotations 1.0 null raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23579 SULF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89262 GSE128076_2_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00246 Supraoptic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.766 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MM485 DepMap CRISPR Gene Dependency 1.0 3.5317 GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947252 Upstream stimulatory factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.653 mesoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.096457 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.9693 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4424 pyelitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.361133 PC-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.74098 PCDHB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76513 BRD-K01973494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36669 GTEX-XYKS-1726-SM-4E3IO GTEx Tissue Sample Gene Expression Profiles 1.0 0.825228 BC-20-WA90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250721 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4828-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.870734 Perturb_15189_KD_TP63_SRP056637 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.8841 NEDD4L Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25181 SLC35A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08087 gammahuman GeneRIF Biological Term Annotations 1.0 null PPP1R3E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87238 cell periphery COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 HOXC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5436 PMC5109294-celldisc201641-s3.xls-NANOGP8_DEGs-Unnamed_9_NANOGP8 Rummagene Transcription Factor Associations 2026 1.0 null Melanoma DisGeNET Gene-Disease Associations 1.0 null MCCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69236 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null BRD-M39894156 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04536 BRD-K77940693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04877 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.75368 BRD-K27476975 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5999 BRD-K17852428 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15341 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83688 monkey GeneRIF Biological Term Annotations 1.0 null mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07918 TRIM25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29819 BRD-K29418729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09071 GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4796 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039275 ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.7089 RORA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7156 Cystic Fibrosis DisGeNET Gene-Disease Associations 1.0 null PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K52731958 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98535 SEC61A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66955 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.877572 BRD-K44548010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03999 SKIC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.79275 CRCGN017_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7505 BRD-K40649636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14048 endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.119452 TSC22D3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K31393518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.282 BRD-K59843356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5933 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23804 VAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07787 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29862 BRD-K61053165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36859 KYSE270 CCLE Cell Line Gene CNV Profiles 1.0 1.40512 nalidixic acid-7367 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null surface GeneRIF Biological Term Annotations 1.0 null VMRCLCD DepMap CRISPR Gene Dependency 1.0 3.99299 BRD-K46141002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2021 BRD-A67787745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.70335 TMBIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82525 CRCGN015_MCF10A_48H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0362 DMS-114 GDSC Cell Line Gene Expression Profiles 1.0 1.96784 spliced GeneRIF Biological Term Annotations 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07368 Amylin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.783 d-54mg cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.5824 sgk11 GeneRIF Biological Term Annotations 1.0 null intracellular sodium ion homeostasis GO Biological Process Annotations 2023 1.0 null TUFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51092 non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.916519 MDAMB134VI CCLE Cell Line Gene Expression Profiles 1.0 2.74744 Sodium channel complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-X585-0011-R5A-SM-46MVI GTEx Tissue Sample Gene Expression Profiles 1.0 0.841859 ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.668 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GT-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TFE3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.787 sensory perception of taste GO Biological Process Annotations 2025 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2802 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-U8XE-1026-SM-4E3HM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21157 BRD-K12705251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01793 NYAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.54851 WDR76 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56202 Renal artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.669 H2AFZ ENCODE Transcription Factor Targets 1.0 null 496100355_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.31859 PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null ion channel activity GO Molecular Function Annotations 2015 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.433374 ONECUT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05202 EEF2K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54366 intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RH-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33383 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.253653 mumps DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.484744 H3-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73527 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.41534 SCAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93853 physiological GeneRIF Biological Term Annotations 1.0 null BRD-K07959057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20204 CEBPD ENCODE Transcription Factor Targets 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41182 BRD-K59744424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21374 FOXA1-25329375-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87932 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063393 channel GeneRIF Biological Term Annotations 1.0 null seta TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.551298 hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MED10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49974 CAOV4 CCLE Cell Line Gene Expression Profiles 1.0 1.95124 GTEX-RTLS-0326-SM-2TF6A GTEx Tissue Sample Gene Expression Profiles 1.0 0.899182 BTRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51194 motility GeneRIF Biological Term Annotations 1.0 null hl60 HPA Cell Line Gene Expression Profiles -1.0 -1.45371 BRD-K05086663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25381 enacalpha GeneRIF Biological Term Annotations 1.0 null GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24357 GSE98898_7_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:A06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0022 CRCGN015_MCF10A_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.35104 PIGT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25234 PGAM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87612 LEMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42314 FD-29-MM50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236535 delta2 GeneRIF Biological Term Annotations 1.0 null GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.93725 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.983 C2CD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10494 squamous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072594 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.996404 CRCGN013_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00752 skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054221 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07836 BRD-K55795421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25893 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P0-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149000_2_v_0_cyp3a5_human RummaGEO Gene Perturbation Signatures 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14555 BRD-K05841284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65548 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 exhibited GeneRIF Biological Term Annotations 1.0 null GTEX-P4QT-0008-SM-48TDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874057 CRCGN008_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3182 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89675 GAL3ST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08425 TMEM170A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4028 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26821 ZFAND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34255 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RPS20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.58088 gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047129 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62847 BRD-K19327124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36257 Cytoskeleton COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 RNF149 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5899 posterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.832081 muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.056866 TPSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15142 CRCGN016_MCF10A.WT.HP_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85156 ATF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16754 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54293 activates GeneRIF Biological Term Annotations 1.0 null BRD-K65506286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83599 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02795 NPFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95415 RMDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68678 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12176 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A55Z-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Calu-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.085 BRD-A23340824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93996 striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.828812 LBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36953 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29852 CCDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49954 BRD-K92444813 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69409 clearance GeneRIF Biological Term Annotations 1.0 null GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.70723 BRD-K30643363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07911 NFIC ENCODE Transcription Factor Targets 1.0 null sodium channel activity GO Molecular Function Annotations 2015 1.0 null MRPS35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90975 testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 1.91287 BRD-K92210988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54184 AHCTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72601 TMEM185A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39403 BRD-K53821452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49112 downregulates GeneRIF Biological Term Annotations 1.0 null cellular response to mineralocorticoid stimulus GO Biological Process Annotations 2025 1.0 null NIHOVCAR3 CCLE Cell Line Gene CNV Profiles 1.0 1.65397 JEG-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null characterized GeneRIF Biological Term Annotations 1.0 null posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.993824 BRD-K30013451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.66372 POU5F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9318 496100613_TCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.33325 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58865 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EB2 CCLE Cell Line Gene Expression Profiles 1.0 1.85126 parathyroid gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.1936 NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0757 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Renal distal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.517 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848705 TIMM21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44181 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEIS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80523 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.93272 GTEX-U8XE-1226-SM-4E3HN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00633 GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null olfactory epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857132 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13617 cell part GO Cellular Component Annotations 2015 1.0 null NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00772 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A07214340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60387 BRD-K38972344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24919 MTMR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79309 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder GTEx Tissue Gene Expression Profiles 2023 1.0 2.92405 RPL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72383 GTEX-Q734-0726-SM-48TZP GTEx Tissue Sample Gene Expression Profiles 1.0 0.950468 SERINC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.00174 AA-68-OJ16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21608 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.55215 endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.060708 NCI-H441 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.407 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WM983B DepMap CRISPR Gene Dependency 1.0 2.0789 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.534 astroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089282 PC3 CCLE Cell Line Gene CNV Profiles 1.0 1.33177 liver HPA Tissue Protein Expression Profiles -1.0 -1.23922 GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles 1.0 1.09969 BRD-K45042519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28885 alters GeneRIF Biological Term Annotations 1.0 null GSE116492,GSE116495_3_v_2_stag2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_1_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null COMMD1 Pathway Commons Protein-Protein Interactions 1.0 null KCND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30216 dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.955811 Cells - EBV-transformed lymphocytes GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.849178 intracellular non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 TM4SF18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13933 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00764 dipyrocetyl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3118 UQCRH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49168 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4669 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTF2F1 ENCODE Transcription Factor Targets 1.0 null GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 0.979266 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25788 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLT-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null Sensory perception of taste Reactome Pathways 2024 1.0 null MDK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86016 496100628_FWM_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.8707 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.250953 PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null TRA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34052 hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23946 NFYB-21822215-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CCNC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63023 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOMM22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41414 MAX ENCODE Transcription Factor Targets 1.0 null GTEX-XUJ4-1526-SM-4BONU GTEx Tissue Sample Gene Expression Profiles 1.0 0.84905 BRD-K73430970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04664 Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.56752 Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Plasma membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ion transport GO Biological Process Annotations 2015 1.0 null CMTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55441 RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.2701 EMC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02959 integral component of membrane GO Cellular Component Annotations 2015 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.479 EFM19 CCLE Cell Line Gene CNV Profiles -1.0 -2.2667 PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06305 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26979 EP300_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sodium ion transmembrane transport GO Biological Process Annotations 2015 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12926 BRD-K98625375 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07396 COX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47285 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.73516 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null inorganic cation import across plasma membrane GO Biological Process Annotations 2023 1.0 null GTEX-W5WG-2226-SM-4LMI3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889371 BRD-A17043706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86455 CD37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77802 egg TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.134277 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34044309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70519 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56207 PMC11696763-41598_2024_79298_MOESM7_ESM.csv--Table_S1_Differentially_expressed_genes_including_ZNF560_were_screened_out_between_normal_and_tumor_tissues_ZNF560 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60942 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null ROS50 DepMap CRISPR Gene Dependency 1.0 6.53153 GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26876 BRCA1_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null BRD-K88948585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09712 CHP126 CCLE Cell Line Gene CNV Profiles -1.0 -1.54551 GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.2405 BRD-K34377350 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99414 AGS DepMap CRISPR Gene Dependency 1.0 3.23751 POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1877 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36188 8-M-PDOT LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95465 BRD-K44807762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20446 Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.685 PSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93863 GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881029 hsa-miR-939 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMD1-0011-R6A-SM-4AT5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.968047 BRD-K86966177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65402 CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.75087 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.38472 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 SSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64293 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05086 BRD-A48478073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96425 EIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88651 sensillum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.494136 NEK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24526 skin_6a HPA Tissue Sample Gene Expression Profiles 1.0 0.894971 HCC2218 CCLE Cell Line Gene CNV Profiles -1.0 -1.56717 GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 0.86296 GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06483 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OU-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hepatitis a DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.433021 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15690866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.18356 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CH-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8436-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82198 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1378 BRD-K81160595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21088 TREX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18511 cerebral GeneRIF Biological Term Annotations 1.0 null FKBP1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49721 uterus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.236627 MSH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25366 FXR MotifMap Predicted Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2ES-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61858 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.889672 Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NT5DC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7047 BRD-K64859133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12444 KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Glossopharyngeal nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.921 molecular_function GO Molecular Function Annotations 2015 1.0 null PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66205 monoatomic cation transmembrane transport GO Biological Process Annotations 2023 1.0 null BRD-K26634627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10734 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNAZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34563 pharmacology GeneRIF Biological Term Annotations 1.0 null GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4339 NCIH209 CCLE Cell Line Gene CNV Profiles -1.0 -1.90123 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12834 BRD-K16387460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14503 GSE239688_4_v_0_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K33710385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31576 CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0376 BRD-A04510218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10173 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041055 CF-24-KQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217904 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4065 BRD-K16891407 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47598 A1BG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85948 KIF5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80057 cation transport GO Biological Process Annotations 2015 1.0 null A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.975371 GSE81796_0_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OAW-28 COSMIC Cell Line Gene Mutation Profiles 1.0 null brain GeneRIF Biological Term Annotations 1.0 null BRD-K47482563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31709 KP-4 GDSC Cell Line Gene Expression Profiles 1.0 1.42297 SNRNP40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69059 GTEX-XLM4-0011-R8A-SM-4AT44 GTEx Tissue Sample Gene Expression Profiles 1.0 0.890795 cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 hepatitis b DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.428891 Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 H2BC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17102 Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.981436 lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.302838 CDCA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38089 GAK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92231 EXOSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86096 pharmacogenomic GAD High Level Gene-Disease Associations 1.0 0.293278 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21523 ITPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34052 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Polymeric cytoskeletal fiber COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37454 CRCGN015_MCF10A_48H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.23369 BRD-A47166394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3199 NRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01107 BRD-K99331869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4282 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AU-01A-32R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RERFLCAI CCLE Cell Line Gene Expression Profiles -1.0 -2.11228 CXXC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17286 BRD-K04706894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76481 Respiratory epithelium cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.225 LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.971949 GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles 1.0 1.47148 PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null proteolytic GeneRIF Biological Term Annotations 1.0 null icSARS CoV_48Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.774931 BRD-K05799189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31535 intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054957 GTEX-RNOR-1326-SM-48FDE GTEx Tissue Sample Gene Expression Profiles 1.0 0.918252 CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35386 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1115 sensory perception of taste GO Biological Process Annotations 2015 1.0 null PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null E2F8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5126 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25495 lung GeneRIF Biological Term Annotations 1.0 null extrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.338341 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.45655 musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046393 organelle part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31373 EC-GI-10 GDSC Cell Line Gene Expression Profiles 1.0 1.65002 SMAD2/3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233872 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.78775 CD81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2023 GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15855 MSC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17065 Gastrointestinal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.688 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.49943 OCI-LY-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.70426 cytoskeleton GO Cellular Component Annotations 2025 1.0 null SPATC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44618 THAP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76982 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.861375 PMC11968908-41420_2025_2421_MOESM1_ESM.docx-1-ELK1_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null Polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.146 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.97552 MLYCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70589 CRCGN017_MCF10A.WT.HP_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.34945 GOLGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56514 BRD-K00933790 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15703 Sarcoma_SARC_TCGA-PC-A5DN-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06058625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71061 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-05A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTPRS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14639 CRCGN014_HEPG2_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27323 BFTC-909 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.34783 Perturb_7509_OE_ILF3_SRP195616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.12545 DIPK1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9295 CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.60682 alphabetagamma GeneRIF Biological Term Annotations 1.0 null GTEX-WHSE-0011-R11A-SM-3P5YY GTEx Tissue Sample Gene Expression Profiles 1.0 1.20984 NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01586 humans GeneRIF Biological Term Annotations 1.0 null clozapine-4453 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051829 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053253 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15486 TMEM92 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7817 ZFYVE27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62777 orofacial cleft DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.145454 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF3B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4498 LDOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32933 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A856-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.944888 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.47528 HNF4A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism transport GO Biological Process Annotations 2015 1.0 null HUH6 CCLE Cell Line Gene CNV Profiles 1.0 1.71686 ERCC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02729 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.841161 SNU738 CCLE Cell Line Gene CNV Profiles -1.0 -2.12004 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30993 BRD-K33151492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05083 PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR Rummagene Transcription Factor Associations 2026 1.0 null TCF21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7217 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87686 BRD-K15474464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54002 UBXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9156 JHH1 CCLE Cell Line Gene CNV Profiles 1.0 1.89232 BRD-K53988836 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63428 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.4185 PHOSPHO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9306 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12596 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.173 SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.24759 NFKBID CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06304 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.343 hsa-miR-516a-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.474009 GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97824 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 0.981469 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.30399 astroglia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.088224 ARHGAP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57361 GTEX-S341-0008-SM-4AD6D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935389 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10557 GATA6-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.70426 TRIM46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14136 GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles 1.0 1.08341 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.917428 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01722 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 68.6382 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.98999 CRCGN015_MCF10A_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.68707 PURA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2762 GABARAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61522 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4IQ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SkeletalMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.99479 GSE140322_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null passive transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null IZUMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07647 BRD-K91189798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90158 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6YA-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_13_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null enhanced GeneRIF Biological Term Annotations 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.838252 BRD-K03765511 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18631 WDR53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56138 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39856 ACBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13581 Sarcoma_SARC_TCGA-DX-A3UD-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MITF ChEA Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKG-IIIA COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K04426746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74547 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96379403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27221 MM160113 DepMap CRISPR Gene Dependency 1.0 3.36382 classical GeneRIF Biological Term Annotations 1.0 null BRD-K57274378 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.45425 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03705 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04446 GTEX-XUZC-1026-SM-4BOPY GTEx Tissue Sample Gene Expression Profiles 1.0 0.932286 NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.877359 DHX57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.67382 primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.833408 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 1.75485 intracellular monoatomic cation homeostasis GO Biological Process Annotations 2023 1.0 null G-402 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12237 colon_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.83569 H1-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61882 HNRNPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29038 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2131 viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.464283 GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles 1.0 1.13867 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.04919 BRD-K20829034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37207 MKN74 CCLE Cell Line Gene CNV Profiles -1.0 -1.78185 kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.078274 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.589 BRD-K96154586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15961 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.759824 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61861 vacuole LOCATE Predicted Protein Localization Annotations 1.0 null BRD-A97608543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72938 GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null coronary artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.399334 primary motor-sensory cortex (samples)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22807 membrane COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 BNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07189 Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tongue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.369373 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042936 culture filtrate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.433757 STXBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76304 GSE207471_2_v_3_btla_human RummaGEO Gene Perturbation Signatures 1.0 null ANKRD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61263 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37817 Nose TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE114553_0_v_1_lhx6_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles 1.0 0.825312 GSE209601_2_v_1_mef2a_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K16800391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.44226 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28538 GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893344 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K59587063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78143 GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.28425 SELENOM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54223 BRD-K19652835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26418 GTEX-QEL4-0526-SM-3GIJ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11753 GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.56851 PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_14_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K43192646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02275 GSE158834_10_v_6_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25835 VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.17808 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01665 GSE80537_3_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures -1.0 null U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.93991 TOMM20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82734 EIF5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93552 BRD-K06529600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9069 tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40292 NCI-SNU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null RAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24311 BRD-A81615860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65883 COLO668 CCLE Cell Line Gene CNV Profiles 1.0 1.51457 MIAPACA2 CCLE Cell Line Gene Expression Profiles 1.0 2.30412 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6491-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular response to alcohol GO Biological Process Annotations 2025 1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null transcriptionpolymerase GeneRIF Biological Term Annotations 1.0 null enhances GeneRIF Biological Term Annotations 1.0 null T3M3 DepMap CRISPR Gene Dependency 1.0 2.83294 SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.00271 PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null SIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56181 PVR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.6928 ion transmembrane transport GO Biological Process Annotations 2015 1.0 null CREB_DEPLETION_GDS3487_41_human_K562 myeloid leukemia cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14938 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.552 KNS42 CCLE Cell Line Gene CNV Profiles -1.0 -2.8354 ligand-gated ion channel activity GO Molecular Function Annotations 2015 1.0 null GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36067 BRD-K24377650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34137 Membrane COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2819 BRD-K17609687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12802 Lung squamous cell carcinoma_LUSC_TCGA-77-8131-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01564 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00168 QRSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34554 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 RBPJ-21746931-IB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858309 Autoimmune disease of gastrointestinal tract DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3585 CINP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22656 cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54139 herpes simplex DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.253831 COL4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11009 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13591 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.939542 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25468 CREB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25598 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4734-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04918285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3334 QSOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06801 496100339_HIP_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.67919 RORB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3399 BRD-A55063801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2826 NAPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03538 NALM19 CCLE Cell Line Gene Expression Profiles 1.0 1.37165 promoting GeneRIF Biological Term Annotations 1.0 null hsa-miR-335-5p MiRTarBase microRNA Targets 1.0 null NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5247 PRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89043 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.901573 BRD-K83115435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10698 STAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.281 PMC12179083-Table_6.xlsx-VCF_Variants_Master_File-Gene_symbol_TBX1 Rummagene Transcription Factor Associations 2026 1.0 null WM-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A47428621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91142 HSD3B7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27286 features GeneRIF Biological Term Annotations 1.0 null KYSE-510 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K57315740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1825 FAM217B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65259 NCIH1963 CCLE Cell Line Gene CNV Profiles -1.0 -1.43161 striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52514 BRD-K92358687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69826 BRD-K24877937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32706 TATDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30294 COLO-741 GDSC Cell Line Gene Expression Profiles -1.0 -1.70108 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047391 H1-3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34203 BRD-K04067194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3648 ATP6V0D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23053 GTEX-XXEK-1226-SM-4BRUY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849152 GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19996 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54629 ISX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81371 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56023 lung TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32708 cornea TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.232317 17210682-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.46431 MYRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38694 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34229 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null sensory perception of salty taste GO Biological Process Annotations 2025 1.0 null CRCGN009_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.42416 revealed GeneRIF Biological Term Annotations 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85413 INSIG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18876 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01656 Cystic fibrosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.77 NUDT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42364 184A1N4 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.01911 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1878 single-organism process GO Biological Process Annotations 2015 1.0 null RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.8948 15656903-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null metal ion transport GO Biological Process Annotations 2023 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chloride channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.072 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 90.3663 BRD-K65441343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74184 dynaminindependent GeneRIF Biological Term Annotations 1.0 null EHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87654 situ GeneRIF Biological Term Annotations 1.0 null GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34841 internalization GeneRIF Biological Term Annotations 1.0 null SLITRK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68817 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056722 MEWO CCLE Cell Line Gene CNV Profiles 1.0 2.02698 cleft lip DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.264431 GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.66249 Alveolar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.202 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981958 ONS-76 GDSC Cell Line Gene Expression Profiles -1.0 -1.53274 retinal edema DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.437906 NUCB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37619 actin cytoskeleton COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K10087503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23763 PIFO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66907 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4543 BRD-K91944762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09867 spondyloarthropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.257711 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.962135 V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.71219 Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.59036 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9726 GSE209601_0_v_1_mef2a_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.35329 GADD45GIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35177 prostate HPA Tissue Protein Expression Profiles -1.0 -1.23922 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.464 GTEX-WOFM-1726-SM-3MJFA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30324 BRD-K49704392 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00229 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14582 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K51681402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49237 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20858 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35165 BRD-K15742845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70991 FAM86C2P CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2546 GTEX-QXCU-0126-SM-2TC5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.982221 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0632 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43458 18625725-TableS1 GeneSigDB Published Gene Signatures 1.0 null cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.956574 GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48116 GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832231 u266 HPA Cell Line Gene Expression Profiles 1.0 1.43525 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13086 GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26858 LENG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4806 SPSB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07183 actin filament COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00443 NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.941338 BRD-K95111937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15078 JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28357 HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.828226 C19orf53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50049 HCC70 DepMap CRISPR Gene Dependency 1.0 4.64956 HS 695T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00966 BRD-K20053005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17062 NAPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75783 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.09105 BRD-K24312231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2772 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 2.05304 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles 1.0 1.07214 GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null SUIT-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.60841 ZNF426 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.345 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82758 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 1.31334 MM253 DepMap CRISPR Gene Dependency 1.0 4.86648 GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null H1_BMP4_Derived_Mesendoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.15724 GSE221577_1_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08717 CEBPB ENCODE Transcription Factor Targets 1.0 null BRD-K79402882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63893 PMC7017485__F4 PFOCR Pathway Figure Associations 2024 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JF-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KP2 DepMap CRISPR Gene Dependency 1.0 6.70404 PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35284 NCOA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46391 IM95 CCLE Cell Line Gene Expression Profiles -1.0 -1.55447 USP17L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78783 PF382 CCLE Cell Line Gene Expression Profiles 1.0 1.80366 capsazepine GeneRIF Biological Term Annotations 1.0 null GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles 1.0 1.06358 Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null glioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.162873 NMC-G1 GDSC Cell Line Gene Expression Profiles 1.0 1.51833 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.922733 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4706-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K17136501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38842 GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05565 PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854605 BRD-K05940224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02339 hel HPA Cell Line Gene Expression Profiles -1.0 -1.25724 ADGRL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71826 pleural mesothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.692902 SEC23A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39361 converging GeneRIF Biological Term Annotations 1.0 null FXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68721 BRD-K96560179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08412 BRD-K47887272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2908 GTEX-WL46-0011-R5A-SM-3LK6V GTEx Tissue Sample Gene Expression Profiles 1.0 0.900477 GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.949702 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18793 orbital frontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.925748 GTEX-SE5C-0426-SM-4BRUI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53596 rectum HPA Tissue Gene Expression Profiles -1.0 -1.82158 furegrelate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4751 PAX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1181 Penis_Foreskin_Keratinocyte_Primary_Cells_skin03 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.884528 NCIH3122 DepMap CRISPR Gene Dependency 1.0 3.05866 496100320_PCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.05215 CYREN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98769 BRD-K58930048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06615 SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.493464 BRD-A08191729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36496 ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.8986 cellbased GeneRIF Biological Term Annotations 1.0 null BRD-K15714771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4382 monoatomic cation transmembrane transport GO Biological Process Annotations 2025 1.0 null GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22632 Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-01A-21R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K38190084 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57862 PSS008 DepMap CRISPR Gene Dependency 1.0 2.01065 karpas707 HPA Cell Line Gene Expression Profiles 1.0 1.29957 GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.106 KRT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99671 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.851684 GSE184356_1_v_2_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null GSE206226_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null 253J CCLE Cell Line Gene Expression Profiles 1.0 1.45834 BRD-K98224452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59267 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848074 Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIN28B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22623 GTEX-U4B1-1926-SM-3DB9E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836649 neuroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066639 BRD-A68123879 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12457 Ulcerative colitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.302838 ANGEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95186 cleft palate DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.200982 andor GeneRIF Biological Term Annotations 1.0 null RI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14584 TKKK DepMap CRISPR Gene Dependency 1.0 4.28639 GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51014 LUC7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01096 BRD-K30236306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67396 PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Microscopic colitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 BRD-K17367110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6588 GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00079 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15092 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23858 Stomach smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.807 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.60091 LRRC75B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46845 cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22807 hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.997936 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.45329 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41909 GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles 1.0 0.881661 BRD-K58787433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16067 VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.17017 cardia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.427636 POU3F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.26 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50233 BRD-K19817946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04766 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19399 GTEX-WZTO-2826-SM-3NM8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.34772 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912756 juvenile TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.539396 BRD-K75815721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.22447 Intracellular non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 IFI16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87871 h9c2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.278955 16778177-Table3 GeneSigDB Published Gene Signatures 1.0 null GLRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24258 BRD-K18519621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38756 BRD-K20028052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54085 VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06843 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.923361 BRD-A77328129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.57472 metal ion transport GO Biological Process Annotations 2015 1.0 null non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null BRD-K45628030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02388 BRD-K98953346 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03146 BRD-K94476572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08128 OSER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30401 GTF2IRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32551 EFR3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93849 IMCD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.136 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1838 CCLE Cell Line Gene Expression Profiles -1.0 -2.03869 bronchial disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.101673 GTEX-X585-0011-R10A-SM-46MUY GTEx Tissue Sample Gene Expression Profiles 1.0 0.853816 BRD-K26809097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03814 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYA-21822215-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null UCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27677 BRD-K59159023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22119 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26987 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84761 GSE217990_0_v_1_rnmt_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K19103580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50837 BRD-A08820802 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96749 fluid GeneRIF Biological Term Annotations 1.0 null P2RX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05014 GSE218060_7_v_0_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null BRD-K63912037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52606 GTEX-QDT8-2926-SM-32PKC GTEx Tissue Sample Gene Expression Profiles 1.0 0.829823 BRD-K56224420 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03758 GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 1.02871 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02615 BRD-A81392774 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69442 subunits GeneRIF Biological Term Annotations 1.0 null BRD-K23296676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0289 GTEX-T5JW-0326-SM-4DM6J GTEx Tissue Sample Gene Expression Profiles 1.0 0.840644 BRD-K24523560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18988 BRD-K13196166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11375 RI1 DepMap CRISPR Gene Dependency 1.0 4.35898 TJAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14099 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE211128_2_v_1_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09423 intracellular part GO Cellular Component Annotations 2015 1.0 null TPRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19783 VCAP DepMap CRISPR Gene Dependency 1.0 3.84011 CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 2.41566 BRD-K88670720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23513 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null metformin-4 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X8HC-2726-SM-46MUA GTEx Tissue Sample Gene Expression Profiles 1.0 1.08259 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052217 neck TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.096886 BRD-K76742876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27752 BRD-K31716785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91463 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.06801 SU-DHL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.76426 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCIH292 CCLE Cell Line Gene CNV Profiles -1.0 -1.64591 NASP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28812 PSME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07722 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4776-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80021 RPUSD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13238 membrane LOCATE Curated Protein Localization Annotations 1.0 null chain GeneRIF Biological Term Annotations 1.0 null cellular response to pH GO Biological Process Annotations 2023 1.0 null BRD-K21206585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08231 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1355 CCLE Cell Line Gene Expression Profiles 1.0 1.50015 Cation channel complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 CHD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68981 BRD-K22670776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24486 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.40453 beta GeneRIF Biological Term Annotations 1.0 null SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.3935 KIF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27838 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0664 GTEX-OHPN-2926-SM-3LK65 GTEx Tissue Sample Gene Expression Profiles 1.0 0.911816 Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.903358 BRD-K24396618 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56029 BRD-K84235037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38046 flow GeneRIF Biological Term Annotations 1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839619 SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05805 GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82814 Liver hepatocellular carcinoma_LIHC_TCGA-HP-A5N0-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.68299 ANKRD46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52542 non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K64751430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.51516 CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.18361 GTEX-XUJ4-2726-SM-4BOQ1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.882463 GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27901 ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4898 FOXC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8203 orbital frontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02382 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36809 NAP1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64736 primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.909466 GTEX-RNOR-2326-SM-2TF4I GTEx Tissue Sample Gene Expression Profiles 1.0 1.01222 CHLA266 DepMap CRISPR Gene Dependency 1.0 4.55014 RANBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07114 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NK-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.64614 EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER ChEA Transcription Factor Targets 2022 1.0 null GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75973 CTCF-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-Q2AG-0526-SM-2S1PW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09573 BRD-A96537953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7719 Sperm mitochondrial sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.959 intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 OVOL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26763 STAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43007 Lung squamous cell carcinoma_LUSC_TCGA-43-6771-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.985319 CRCGN013_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0102 BRD-K98505253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61548 BRD-K60430111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24907 arsenic trioxide_homo sapiens_gpl201_gse48441 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22118 BRD-A64153357 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.5386 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.106798 cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042102 Hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.45164 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.858773 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.08497 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.12328 EVSAT CCLE Cell Line Gene CNV Profiles 1.0 1.75311 sodium ion transport GO Biological Process Annotations 2015 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.83951 SW954 COSMIC Cell Line Gene Mutation Profiles 1.0 null KANSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01482 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.96776 BRD-K31093279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01181 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRPF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29125 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29079 JUND ENCODE Transcription Factor Targets 1.0 null PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766 Rummagene Transcription Factor Associations 2026 1.0 null H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC11551338-pnas.2411189121.sd01.xlsx-PXR-Unnamed_0_NR1I2 Rummagene Transcription Factor Associations 2026 1.0 null NKX2-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14555 BRD-K21786986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15472 GSE221327_4_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.87076 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10577 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4969-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74504 anterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.952848 ZNF722 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77897 CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K15739647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03129 496100631_PCx_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.13574 SEMA4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22196 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12435 GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles 1.0 1.23742 BRD-A16760970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37959 Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K00557942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29915 Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68980973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11104 TBX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29233 Measles Chicago-1_24Hour_16492729_GSE980 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.75596 NRF1 JASPAR Predicted Transcription Factor Targets 1.0 null HNF4G_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PABPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.424 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.883202 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.99239 BTN3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53277 CXCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76537 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.03013 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RABEPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06907 SH3BGRL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01274 outer SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01808 LRP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55914 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IM-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null L1236 CCLE Cell Line Gene Expression Profiles 1.0 1.70534 respiratory mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K72666100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04731 BRD-K40164971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84464 LENG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37492 Platelet dense granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.118 Perturb_16449_KO_MIR22_SRP277508 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.66999 bemegride-3051 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234043_3_v_1_abcb1_human RummaGEO Gene Perturbation Signatures -1.0 null RCOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73592 BRD-K51608472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53402 Perturb_1355_KO_circSCL38A1_SRP342299 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.7951 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894248 hsa-miR-4309 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.88251 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null COA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55386 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPMI 2650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37619 macular retinal edema DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.477151 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848074 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.929541 MCC26 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K38984040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94118 EFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80117 ESRRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3861 GSE233112_2_v_0_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045529 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67183010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02786 tonsil_8b1 HPA Tissue Sample Gene Expression Profiles -1.0 -1.4978 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.67179 DHX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3872 GTEX-UJHI-1226-SM-4IHLR GTEx Tissue Sample Gene Expression Profiles 1.0 1.08885 Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6522 WDR44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66119 PBX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30541 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848705 Connecting tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.835 PITX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81416 BRD-K35336753 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75545 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.994334 NCIH1618 CCLE Cell Line Gene Expression Profiles -1.0 -2.76631 UBE2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6906 HT-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Large intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06983 Cell periphery COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 CRCGN016_MCF10A.WT.HP_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.83646 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44601 PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.914664 DTX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20979 Benign mammary dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.618 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.898552 GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 1.08605 GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7979 GSE240386,GSE242143_1_v_4_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67577 BRD-K00243272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2223 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857271 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A6UC-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K37203382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5027 CRCGN014_HEPG2_3H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05875 GTEX-PWCY-1426-SM-48TCT GTEx Tissue Sample Gene Expression Profiles 1.0 0.84349 E2F1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K12336887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00449 response to vasopressin GO Biological Process Annotations 2025 1.0 null adrenal_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.33791 BRD-K61485947 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42794 GTEx Muscle 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 9.27231 Lateral ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 C11orf87 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98306 reverse GeneRIF Biological Term Annotations 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42182 BRD-K00507184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60783 RPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40092 ATP1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3952 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TE-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null genital herpes DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.603811 BRD-K45712538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19652 GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.09754 Apical plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.549 metal ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null response to vasopressin GO Biological Process Annotations 2023 1.0 null BRD-K84062787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50023 hippocampus (hippocampal formation)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01276 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866483 Perturb_6493_KD_DPY30_SRP341550 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.84314 NSUN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60705 SMNDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21312 NAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12169 BRD-K89632963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07713 GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 2.03977 BRD-K50367303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33132 RDH11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67712 MAP4K3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0307 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5349 KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.840537 GPATCH11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86556 CCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09899 BRD-K90693562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16954 BRD-K12613826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03982 NEU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5921 malignant glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.05888 MARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66308 GSE180185_7_v_10_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33608 GTEX-SNMC-1626-SM-4DM52 GTEx Tissue Sample Gene Expression Profiles 1.0 0.91133 GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882047 LIN7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22085 CRCGN016_MCF10A.TP53.M_24H:P18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59755 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRAF3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79478 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K81997160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0672 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.850922 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43133 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MALME 3M BioGPS Cell Line Gene Expression Profiles -1.0 -1.75043 GTEX-PWCY-1326-SM-48TCU GTEx Tissue Sample Gene Expression Profiles 1.0 0.883927 Respiratory failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.262 ZNF845 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96376 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15443 GNB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11103 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32755 GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 0.848826 WASF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57667 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04596 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29985 GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58357 APEX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68043 BRD-K01278504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0197 GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937227 FUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56861 GSE128333_3_v_5_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.947378 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231720,GSE231724_2_v_1_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.877572 BRD-K07988588 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13187 PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08571 MYBPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83288 BRD-K44139682 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13473 BCAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73787 KLF4-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86508 pyelonephritis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.36187 astrocytoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.095509 GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03911 OCT4-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K37544873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07136 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.912807 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Amiloride DrugBank Drug Targets 1.0 null GTEX-X4EO-2726-SM-4E3HS GTEx Tissue Sample Gene Expression Profiles 1.0 0.875365 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06052 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.895209 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32158 BRD-K29328556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29916 Initial collecting tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.969 SELENOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71166 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30993 GTEX-S341-0726-SM-4AD5R GTEx Tissue Sample Gene Expression Profiles 1.0 0.867758 Perturb_17528_KD_MEOX1_SRP213607 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GPR180 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52707 BRD-K34277236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09203 HOXC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1613 GRAMD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.73452 SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58425 BRD-K14359942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32922 NCI-H1650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46451 RNF40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01479 Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMIM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84562 BRD-K07588901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25511 BRD-K86008496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06688 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 NBSUSSR COSMIC Cell Line Gene Mutation Profiles 1.0 null DMRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83248 intestinal infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.528835 GSE162575,GSE162609_3_v_2_tfe3_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PUSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40921 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null plasma membrane GO Cellular Component Annotations 2015 1.0 null NAA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35186 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45092 Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.608 SLC29A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49876 BRD-K03515786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39873 GSE105169,GSE105175_0_v_1_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K11054031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.43851 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07457 GSE147893,GSE147897_2_v_1_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null JRK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72508 GRK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30278 integral component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.139549 CELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51352 DAUDI CCLE Cell Line Gene Expression Profiles 1.0 1.54033 GSE128333_2_v_1_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF85 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19892 GTEX-XMD3-2326-SM-4AT5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.2007 BRD-K40509138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53344 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23773 ZNF154 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65156 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30905 enacs GeneRIF Biological Term Annotations 1.0 null inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040964 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2468 PRPSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34352 salivarygland_6a HPA Tissue Sample Gene Expression Profiles 1.0 0.965032 RAB3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43274 GSE80098,GSE80366_0_v_4_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.12847 BRD-K36324810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92871 membrane GO Cellular Component Annotations 2015 1.0 null GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17645 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48628 cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null myoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.157015 testis_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.920976 SKOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9195 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.2835 TSEN54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29179 CEP250 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80918 BRD-K29684372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48042 LCN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99338 AA-62-OC45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.265208 BRD-K19040998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46061 protein complex COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 ZNHIT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0858 rt4 HPA Cell Line Gene Expression Profiles -1.0 -1.70761 SMYD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32446 FLYWCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67985 MDAMB468 CCLE Cell Line Gene CNV Profiles 1.0 1.82596 GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles 1.0 1.14305 EOL-1-CELL COSMIC Cell Line Gene Mutation Profiles 1.0 null ZKSCAN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29015 CD105+_Endothelial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.6467 primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.975622 GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01339 endocytosis GeneRIF Biological Term Annotations 1.0 null BRD-K73095160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30532 primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05731 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MGAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65239 BRD-K86845405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18985 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.57047 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8324 taste bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.465335 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIMA CCLE Cell Line Gene CNV Profiles -1.0 -1.445 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.83338 BRD-K76997656 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13036 SLC5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10898 BRD-K31960013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89116 CRCGN009_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.49491 BRD-A85216385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50307 hair TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33046 CEBPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1352 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5258 CRCGN016_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.17578 sensory perception of sour taste GO Biological Process Annotations 2023 1.0 null GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3 GSE135400_1_v_0_kdm1b_human RummaGEO Gene Perturbation Signatures -1.0 null FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null retinal vein occlusion DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.566054 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -3.07198 GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles 1.0 0.862485 vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.237009 icSARS CoV_30Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.281 1p36 copy number variation syndrome WikiPathways Pathways 2024 1.0 null GSE140322_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Intestinal disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.688 KARPAS422 DepMap CRISPR Gene Dependency 1.0 3.28465 cation channel complex GO Cellular Component Annotations 2025 1.0 null central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.32913 MED14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73641 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null actin cytoskeleton GO Cellular Component Annotations 2015 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59183 healthy GeneRIF Biological Term Annotations 1.0 null BRD-K66733186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5069 MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88345 cellular response to acidic pH GO Biological Process Annotations 2025 1.0 null C5orf22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88778 CBX2-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40454 BRD-K52335877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.6337 GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0996 GTEX-X4EO-0126-SM-3P5YN GTEx Tissue Sample Gene Expression Profiles 1.0 1.00974 Tongue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.694 TMEM184B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10728 BRD-K10423475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28292 SMARCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65296 NCIH1650 CCLE Cell Line Gene CNV Profiles -1.0 -2.02758 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52619 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.965124 MRPL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95651 BRD-K35978846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1706 lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045018 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57827 BRD-K19766710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0177 muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.055938 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.975622 posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.831384 IZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.910653 NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44485 BRD-K62976536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26987 RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.892118 BTD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05649 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7854 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.48559 SAP30L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59537 BRD-K55742134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86194 ligand-gated monoatomic cation channel activity GO Molecular Function Annotations 2025 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SH3D19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35436 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.083 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76173551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01287 ZSCAN21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72328 DCAF12L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12837 intestine-407 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.94 KPNSI9S CCLE Cell Line Gene CNV Profiles -1.0 -2.67264 Testis GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.649495 OLFML3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4405 sodium channel complex GO Cellular Component Annotations 2025 1.0 null PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR Rummagene Transcription Factor Associations 2026 1.0 null C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07836 E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NB10 DepMap CRISPR Gene Dependency 1.0 4.75684 layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25665 UFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66596 GRANTA519 CCLE Cell Line Gene CNV Profiles 1.0 1.51679 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DQ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.924 IGFBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6322 AR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41344 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBED2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4202 CFAP126 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90657 BRD-K35441510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20281 primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.93564 IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.825072 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.82391 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30951 Lung adenocarcinoma_LUAD_TCGA-97-A4M1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K63242692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27634 FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0945 GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.19698 PMM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80291 COLO775 CCLE Cell Line Gene Expression Profiles 1.0 1.40541 LMCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19843 DTYMK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83299 GTEX-WRHK-1726-SM-3MJFK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853595 GTEX-QMR6-1426-SM-32PLA GTEx Tissue Sample Gene Expression Profiles 1.0 0.857489 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.972563 NAGPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1724 EGR1 ChEA Transcription Factor Targets 1.0 null BRD-K94444134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81164 SPCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7594 Prostate adenocarcinoma_PRAD_TCGA-YL-A8HO-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Iron uptake and transport(Homo sapiens) WikiPathways Pathways 2014 1.0 null IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.904204 monovalent inorganic cation transport GO Biological Process Annotations 2015 1.0 null AOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34241 Polycystic kidney disease 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.334 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24762 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A541-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null D-54MG cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.824 MOB1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79801 BRD-K75772626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51455 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50964 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.301 biological_process GO Biological Process Annotations 2015 1.0 null GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24691 BRD-K49698948 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82721 GATA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5698 GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32971 Diabetes Mellitus, Type 2 HuGE Navigator Gene-Phenotype Associations 1.0 null CCDC66 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03966 BRD-K06743908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0718 CRCGN015_HEPG2_48H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.51957 BRD-K47599661 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2151 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38394 baseline GeneRIF Biological Term Annotations 1.0 null BRD-K95428783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23117 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.906578 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.91489 CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.084 Enterovirus 71_8Hour_None_GSE15323 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.10672 RD GDSC Cell Line Gene Expression Profiles 1.0 1.53029 GSE195568_2_v_4_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null ARHGAP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89471 HOXA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41382 GSE195568_3_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Lung TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.857014 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.7811 YJU2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65728 chronic pyelonephritis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.685491 GINS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83189 cellular response to ketone GO Biological Process Annotations 2025 1.0 null CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.94519 prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1099 testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 1.70405 Apical part of cell COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ZNF143 ENCODE Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.975098 IGF1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53277 TUBB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07842 Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NR2C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.751 BRD-K15924535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06379 temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K00804254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.60759 BRD-K31030467 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70892 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 1.10927 RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.3989 CRCGN008_HEPG2_24H:J03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.522 BRD-K92701606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86417 clearly GeneRIF Biological Term Annotations 1.0 null RNF34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28943 NIFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12525 CELSR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58066 deltabetagamma GeneRIF Biological Term Annotations 1.0 null IZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872803 BRD-K71537579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40497 AGO1_02_95 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60145 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.874012 GSE48812_0_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.955859 P2URK562 DepMap CRISPR Gene Dependency 1.0 4.14899 BRD-K68300789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77897 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10528 biophysics GeneRIF Biological Term Annotations 1.0 null hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01177 amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21724 DYNC2I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55305 CLPTM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39108 HOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05563 BRD-K04513994 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26597 PCMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30697 IZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42934 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WNK3 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11868582-41423_2025_1264_MOESM4_ESM.xlsx-Table_S10-Table_S10_List_of_FICZ-induced_or_FICZ-suppressed_and_OVOL1-dependent_genes_OVOL1 Rummagene Transcription Factor Associations 2026 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K56034970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2061 sodium:potassium-exchanging ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.858 Acute Myeloid Leukemia_LAML_TCGA-AB-2934-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K99022424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05621 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.341 lateral nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.832216 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.45555 ARID3A ENCODE Transcription Factor Targets 1.0 null UQCRHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57763 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.883753 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42783 pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17228 BRD-K36095954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65841 PARG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10388 GTEX-OHPL-3026-SM-3MJGS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04298 BRD-K86722849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02115 cheek TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.289582 BRD-A00680357 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00174 TRPS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3689 HOXD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95467 TMCO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46299 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16002 E2F4 ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.40235 intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048343 FAM234B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13901 ETV1-20927104-GIST48-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.848074 HPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13422 respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042788 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.935648 GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.980778 IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67531 system process GO Biological Process Annotations 2015 1.0 null GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37793 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.871606 OVTOKO CCLE Cell Line Gene Expression Profiles 1.0 1.41872 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.65673 lifespan GeneRIF Biological Term Annotations 1.0 null colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058046 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.47213 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00449 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921484 GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.828417 HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26636 GSE225735_0_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A86748098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73203 BRD-K69872823 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26304 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041341 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GIGYF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09578 GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10018 astrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.090398 SFT2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25539 T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.69624 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.11136 PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null SOX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63008 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07037 bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055382 Ion channel transport Reactome Pathways 2024 1.0 null PCGF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03756 GSE169152_3_v_6_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25495 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89675 RPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85321 BRD-K81124412 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35124 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039188 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.03057 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34624391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22121 BRD-K17059629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22508 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.972385 Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OSTM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41308 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03578 ZNF560 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96584 cellular response to peptide hormone stimulus GO Biological Process Annotations 2023 1.0 null MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.9064 GTEX-X638-0426-SM-47JY2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06832 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null MYO18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34277 Alveolar epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.258 GSE201270,GSE201272_5_v_1_mybl2_human RummaGEO Gene Perturbation Signatures 1.0 null 496100654_HIP_no dementia_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.37905 myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.183541 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986966 differs GeneRIF Biological Term Annotations 1.0 null EVX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94143 LPAR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17642 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.30836 GTEX-T5JW-2026-SM-4DM63 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830227 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.976191 NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64834 BRD-K97343426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26402 PMC12179083-Table_6.xlsx-VCF_Variants_Master_File-Gene_TBX1 Rummagene Transcription Factor Associations 2026 1.0 null RBM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10441 BRD-K29509140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70463 EE-98-PF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.205391 BRD-K27692586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11165 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RY-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.87771 BRD-K93391478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56441 EXOSC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40101 ZNF547 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6934 primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.825863 ISOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94197 SLFN14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57168 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.70086 Pleural mesothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.275 SPHK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92048 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.865658 HNF4A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null AVL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15831 UBC Pathway Commons Protein-Protein Interactions 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.61513 Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1036 GTEX-WEY5-2126-SM-3GILK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922162 MAZ ENCODE Transcription Factor Targets 1.0 null GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.25459 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null neurological system process GO Biological Process Annotations 2015 1.0 null Metabolic Syndrome X HuGE Navigator Gene-Phenotype Associations 1.0 null membrane LOCATE Predicted Protein Localization Annotations 1.0 null TLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06062 REPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65866 HELZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34404 single-organism cellular process GO Biological Process Annotations 2015 1.0 null KDM2B-26808549-CHIP-SEQ-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null VANGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48183 UO31 BioGPS Cell Line Gene Expression Profiles 1.0 1.11715 GSE158834_10_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043691 KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33322 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-A64985224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48594 SEPTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9302 heart muscle HPA Tissue Protein Expression Profiles -1.0 -1.23922 BRD-K69375224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02529 CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.618 Glioblastoma multiforme cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.758 KNS-62 GDSC Cell Line Gene Expression Profiles -1.0 -2.21117 BRD-K97624648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1429 IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33233 ZSCAN20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65085 BRD-K98537764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50988 recycling GeneRIF Biological Term Annotations 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.931007 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92211 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3745 BRD-K27653895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3371 GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07484 Vallate papilla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.564 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4718-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02554 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28673 A4GALT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61421 SPAG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05491 lysosome LOCATE Predicted Protein Localization Annotations 1.0 null CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33546 Down Syndrome_Fetus_GSE10758 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.41274 496100641_PCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.1721 actin cytoskeleton GO Cellular Component Annotations 2025 1.0 null ZNF516 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13297 PCDHGC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49595 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EK-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 2.08704 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.87185 GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70685 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45X-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE185139_1_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null QGP1 CCLE Cell Line Gene Expression Profiles -1.0 -1.64738 DETROIT562 CCLE Cell Line Gene Expression Profiles -1.0 -2.14096 TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K62102480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27256 SUPT6H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.29732 cortex GeneRIF Biological Term Annotations 1.0 null eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045299 BRD-K49666076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04315 commd1 GeneRIF Biological Term Annotations 1.0 null BRD-K29702569 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32005 GTEX-NPJ8-1826-SM-2YUNC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86964 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transmembrane transport GO Biological Process Annotations 2015 1.0 null G-361 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7T8-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61534 Renal medulla cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.124 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06113 PCSK9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37141 BRD-K51270604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04384 RDM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59999 glial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.097667 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47M-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08317 Acute Lung Injury_Whole blood_GSE10474 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.67346 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061652 GSE60217_1_v_8_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null SFXN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78337 BRD-A01717918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44335 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.49101 Mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE183606_1_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.31918 CRCGN015_HEPG2_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2989 GTEX-XQ8I-0726-SM-4BOPU GTEx Tissue Sample Gene Expression Profiles 1.0 0.897576 TBL1-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K74114857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57072 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15028 BRD-K03221986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53318 PEBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64743 cell part LOCATE Predicted Protein Localization Annotations 1.0 null pyramidal GeneRIF Biological Term Annotations 1.0 null SBC5 CCLE Cell Line Gene CNV Profiles 1.0 1.47609 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9499 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.35503 TAS2R5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88722 GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null GSE159049_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures -1.0 null MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE77108_3_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52119 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.9032 ZCWPW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36283 RTL8C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83512 ZNF283 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91539 one GeneRIF Biological Term Annotations 1.0 null PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Up_MSC Rummagene Transcription Factor Associations 2026 1.0 null MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.984559 YY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8669 MOLT-16 COSMIC Cell Line Gene Mutation Profiles 1.0 null FBXL14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21048 PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null PPP2R5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03394 RIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06445 SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53637 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02772 GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981091 GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89528 GTEX-WFG7-2326-SM-3GIKV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2437 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3113 GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64287 limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XOT4-0326-SM-4B66S GTEx Tissue Sample Gene Expression Profiles 1.0 1.14372 BL1045 (ABL2) NURSA Protein Complexes 1.0 null aortic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.124249 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09699 BRD-K31363949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21906 BRD-K14250524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37503 AGS CCLE Cell Line Gene Expression Profiles -1.0 -1.46567 C80 DepMap CRISPR Gene Dependency 1.0 4.23845 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95539 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829828 blood GTEx Tissue Gene Expression Profiles -1.0 -1.30989 BACH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79532 hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53188 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GIGYF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41535 EPLC272H CCLE Cell Line Gene Expression Profiles 1.0 1.34784 GTEX-QVJO-1325-SM-2S1QX GTEx Tissue Sample Gene Expression Profiles 1.0 1.13351 RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3773 SEZ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19089 PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null MAP4K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40374 GSE184892_7_v_3_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1648 CCLE Cell Line Gene CNV Profiles 1.0 1.39002 GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07036 BRD-A60877539 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59086 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01445 orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.91649 ERMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79057 BRD-K14671528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58365 BRD-K22874335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.11543 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K04785821 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25636 Taste bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.114 single-organism localization GO Biological Process Annotations 2015 1.0 null GTEX-TML8-1626-SM-32QOO GTEx Tissue Sample Gene Expression Profiles 1.0 0.838878 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 TSG101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08244 telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null B4GALT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8542 ETNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33914 HMGXB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51528 Abdominal obesity-metabolic syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.29 inorganic cation import across plasma membrane GO Biological Process Annotations 2025 1.0 null BRD-K28017317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93285 BRD-K97624853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2632 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964862 RCOR1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78748401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75758 PMC9661392__F8 PFOCR Pathway Figure Associations 2024 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 1.79 PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null KPNYN CCLE Cell Line Gene CNV Profiles -1.0 -1.44519 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.62536 cgmppkgii GeneRIF Biological Term Annotations 1.0 null TSNAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8543 NCOA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5654 TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22534934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92245 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ligand-gated monoatomic cation channel activity GO Molecular Function Annotations 2023 1.0 null BRD-A64957606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26968 TMEM191C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71508 BRD-K98586629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.26906 BRD-K71141540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0041 Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.37104 BRD-K08458391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56956 Sensory Perception Reactome Pathways 2024 1.0 null GTEX-PWCY-2226-SM-2S1OP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02576 UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE149621_3_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null GDM1 CCLE Cell Line Gene Expression Profiles 1.0 1.42926 GSE128730_7_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null response to acidic pH GO Biological Process Annotations 2025 1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21255 DPP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12565 urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.064567 BRD-A46950333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46041 HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3155 H2BC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00478 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.890342 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.03123 BRD-K37000177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08062 Perturb_6307_KD_NR2F1AS1_SRP335917 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.00819 solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.864823 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67536 TMEM41B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85151 Left colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.338 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34116 Epilepsy DisGeNET Gene-Disease Associations 1.0 null SW948 DepMap CRISPR Gene Dependency 1.0 2.36446 BRD-K72770355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.351 CML-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CYP2R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29977 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null NB17 DepMap CRISPR Gene Dependency 1.0 4.41938 HCCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11647 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00772 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Sodium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.279 BRD-K71808107 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5988 pathways GeneRIF Biological Term Annotations 1.0 null Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Perturb_12371_KO_NR4A1_SRP293165 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.15794 ERCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96601 CXCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52706 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.57556 KMS28BM CCLE Cell Line Gene CNV Profiles 1.0 1.36974 colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059971 BRD-K88016677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81954 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.976012 A2058 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.896476 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.857882 EPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9123 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null BRD-K87010860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21065 Cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Nucleus preopticus medianus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.85 Ion channel complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 AK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61661 hsa-miR-3138 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 protein-containing complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8954 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3046 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70W-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cardiomyoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.611346 IMR32 CCLE Cell Line Gene CNV Profiles -1.0 -1.79521 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25032 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RE-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Triamterene DrugBank Drug Targets 1.0 null providing GeneRIF Biological Term Annotations 1.0 null telencephalic GeneRIF Biological Term Annotations 1.0 null testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 1.82933 sense organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.432991 LRPAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38537 Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K57734337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56425 ERAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14922 BRD-K77177732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11948 GTEX-X585-3026-SM-46MWF GTEx Tissue Sample Gene Expression Profiles 1.0 1.07382 Perturb_17547_KD_STAT3/HMGN5_SRP354633 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 SUDHL8 CCLE Cell Line Gene Expression Profiles 1.0 2.09679 ZXDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3455 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.89086 Temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03526 GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles 1.0 1.33312 cellular response to aldehyde GO Biological Process Annotations 2025 1.0 null PDRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92321 NY COSMIC Cell Line Gene Mutation Profiles 1.0 null FOXG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45586 Transmembrane transport of small molecules Reactome Pathways 2014 1.0 null GTEX-XMK1-2426-SM-4B66I GTEx Tissue Sample Gene Expression Profiles 1.0 1.11964 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042859 DNAJC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97685 BRD-K20377072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94359 BRD-K04531886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66807 COQ10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01904 Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-02A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89574562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30652 BRD-K77150932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16127 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14556 Actin cytoskeleton COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 ZNF771 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8984 BRD-K47947160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57076 BRD-K76861469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22592 Supramolecular polymer COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856032 BRD-K26257310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10862 layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18735 cellular response to acidic pH GO Biological Process Annotations 2023 1.0 null PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null BRD-K83189379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60483 PALM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18616 CCDC137 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14649 KPNSI9S CCLE Cell Line Gene Expression Profiles -1.0 -1.54261 populations GeneRIF Biological Term Annotations 1.0 null HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.792663 BRD-K66413698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04382 GSE118816_0_v_1_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null PSMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2556 SMURF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90719 BRD-A82843133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53695 GSE102870_1_v_2_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null ZFP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27604 transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K88135858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07261 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01981 CPCN CCLE Cell Line Gene CNV Profiles -1.0 -1.61443 FARAGE DepMap CRISPR Gene Dependency 1.0 2.02207 Cystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.40217 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962182 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.356314 ZNF787 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.24547 Parathyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00339 CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.5612 Distal arthrogryposis type 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.384 Bronchoalveolar system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Usher syndrome type 3A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 BRD-K34858602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28981 response to stimulus GO Biological Process Annotations 2015 1.0 null posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07697 selfinhibition GeneRIF Biological Term Annotations 1.0 null bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043114 CRCGN008_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.27735 ZNF660 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47914 NCIH510 CCLE Cell Line Gene CNV Profiles 1.0 2.27488 epithelial GeneRIF Biological Term Annotations 1.0 null BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Olfactory epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.358 epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066029 Oviductal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.528 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.92058 BRD-K51461946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10347 WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19429 eggshell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.584422 PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K25638876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80286 WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54451 NSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65129 BRD-K34620971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74493 TGFB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39417 bronchitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.192657 SCAPER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34021 tentacle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.726918 BRD-K13389917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30013 PTMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26185 cellular response to mineralocorticoid stimulus GO Biological Process Annotations 2023 1.0 null BRD-K26376097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75866 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55298 RAF1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10128 KLRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01485 XBP1_OE_GDS2861_60_human_MCF7 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null nasal mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC11554977-40199_2024_523_MOESM2_ESM.xlsx-Sheet1-Supplement_2_Metformin_Drug_Sensitivity_and_Damaging_Mutation_by_using_PRISM_Repurposing_Primary_Screen_and_Damaging_Mutation_in_DepMap_PRDM6 Rummagene Transcription Factor Associations 2026 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25445 outer CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05296 substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47196 myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057367 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles 1.0 1.17659 IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.05126 Hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.658 Intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 sodium ion transport GO Biological Process Annotations 2023 1.0 null PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-PATZ1_mod_PATZ1 Rummagene Transcription Factor Associations 2026 1.0 null SLC16A7+ cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null BRD-K32451879 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.041 GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22938 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83336 MLXIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41687 BRD-K06284373 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75111 IQSEC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56086 ESRRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3691 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918663 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null contribute GeneRIF Biological Term Annotations 1.0 null ZNF689 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.96207 abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17185 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8147 SGSH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74035 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K48999921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09295 NCIH1385 CCLE Cell Line Gene CNV Profiles -1.0 -1.84164 SKMEL28 CCLE Cell Line Gene CNV Profiles 1.0 1.33366 BRD-K72071403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12456 dorsolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.97883 SUPT11 CCLE Cell Line Gene CNV Profiles 1.0 1.4567 DUSP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19107 GTEX-XLM4-0011-R6A-SM-4AT4B GTEx Tissue Sample Gene Expression Profiles 1.0 0.895913 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles 1.0 1.21512 ATPAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18833 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.25281 SETSIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0208 PEX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50668 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55853 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null deltaenac GeneRIF Biological Term Annotations 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EPAS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6531 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.59418 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.51959 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.19396 Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930851 ERLIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90523 GTEX-R55E-2526-SM-2TC6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.45386 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.2619 PHTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74737 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41211 cytoskeleton GO Cellular Component Annotations 2023 1.0 null BRD-K92806245 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03235 sodium channel activity GO Molecular Function Annotations 2023 1.0 null BCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55952 mesothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.215147 POU2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6643 cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046723 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.54079 PKD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40191 CRCGN015_HEPG2_48H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61043 Platelet count GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.65561 BRD-K12959846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23667 HNRNPD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84097 VKORC1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24792 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.863521 Transmembrane transporter complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null cellular response to pH GO Biological Process Annotations 2025 1.0 null SDF2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.97467 cell culture TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.218613 sensillum trichodeum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.546533 RBM34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33074 GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25802 COMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06122 SKMEL5 CCLE Cell Line Gene Expression Profiles -1.0 -2.08704 Pulmonary edema DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 specific GeneRIF Biological Term Annotations 1.0 null GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 2.30783 Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPM6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32434 POLR3F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25646 GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97521 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN008_HEPG2_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25255 GSE146982_7_v_5_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09433 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.66271 GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09717 respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.36825 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.901297 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K86593041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58572 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 midbrain raphe nuclei Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.978647 Sodium HMDB Metabolites of Enzymes 1.0 null Perturb_6429_KD_KDM2B_SRP074343 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE128076_1_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K03141963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09835 BRD-K11730256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65298 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07071 actin cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 sodium channel activity GO Molecular Function Annotations 2025 1.0 null ATG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05753 GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null sodium channel complex GO Cellular Component Annotations 2023 1.0 null BFTC909 CCLE Cell Line Gene CNV Profiles 1.0 2.38881 BRD-K01311880 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07387 ligand-gated sodium channel activity GO Molecular Function Annotations 2025 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A622-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MO-T COSMIC Cell Line Gene Mutation Profiles 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.44766 ligand-gated channel activity GO Molecular Function Annotations 2015 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null subcortical GeneRIF Biological Term Annotations 1.0 null DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211676 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 A431 COSMIC Cell Line Gene Mutation Profiles 1.0 null nose TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K09779858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38664 External gill TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.796 GAA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24193 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null MALL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23462 nucleus of Darkschewitsch, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.908816 GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870148 BRD-K95850342 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69382 PIP5K1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26818 Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957001 DMS153 CCLE Cell Line Gene CNV Profiles 1.0 1.61856 GSE182680,GSE182683_10_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null SCLC21H CCLE Cell Line Gene CNV Profiles 1.0 2.44221 proton GeneRIF Biological Term Annotations 1.0 null BRD-K29903367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64262 KIAA1671 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73023 melanoma GeneRIF Biological Term Annotations 1.0 null brain cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.086676 496100610_TCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.3139 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.983337 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54991 ARC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74575 Bladder Urothelial Carcinoma_BLCA_TCGA-YF-AA3L-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SEPTIN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37088 cytoskeletal part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.878207 BRD-K61209548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53596 MRPL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19956 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBXN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23421 Renal tubular transport disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.361 BRD-K86036680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36045 ZNF483 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12637 SA1-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE155836,GSE155839_3_v_2_alvocidib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QCQG-1926-SM-2S1PI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975674 GTEX-UPJH-0626-SM-4IHJN GTEx Tissue Sample Gene Expression Profiles 1.0 0.866917 GSE181461_1_v_4_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-A87325732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73531 GSE140322_3_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K94876980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23073 BRD-A45014336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46773 icSARA deltaORF6_36Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.51385 NKX2-8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12779 TAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95837 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX11_DEPLETION_GDS4801_326_human_Z138 mantle cell lymphoma (MCL) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18388 primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043377 SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.986624 BRD-K43224838 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32294 Amiloride HMDB Metabolites of Enzymes 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE123943_4_v_5_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRK-0526-SM-3NB2F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914605 PPP1CC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38576 NCIH810 CCLE Cell Line Gene Expression Profiles -1.0 -1.50188 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Collecting duct cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.156 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.1468 GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03041 BRD-K64717502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53322 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.446314 therapeutic GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AG-2926-SM-2HMJ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02961 DACT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15857 aortic aneurysm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.137491 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.91632 astroglial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089282 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4054 ZNF561 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99818 BRD-K83180232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00546 BRD-K45315294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1959 HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08782 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11665 BRD-K66939340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28315 GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20243 BRD-K03243737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05501 PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60035 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92655 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MITF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7861 RERF-LC-FM COSMIC Cell Line Gene Mutation Profiles 1.0 null sensing GeneRIF Biological Term Annotations 1.0 null GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23205 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7PW-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 GSE153867_6_v_8_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37029 primary auditory cortex (core)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.971444 BRD-K00676343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19647 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962182 BRD-A73618687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1509 hydrochloride GeneRIF Biological Term Annotations 1.0 null BRD-K56032186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09999 SMAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5982 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.918649 UBAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75721 Omasum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.112 PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K33005275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04816 NU-DUL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null HNF4G ENCODE Transcription Factor Targets 1.0 null NCIH2004RT DepMap CRISPR Gene Dependency 1.0 3.30258 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.971977 BRD-K77024507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50715 RPIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93882 HELA BioGPS Cell Line Gene Expression Profiles 1.0 1.18033 HN CCLE Cell Line Gene CNV Profiles 1.0 1.58 GSE229580_0_v_3_creb1_human RummaGEO Gene Perturbation Signatures 1.0 null GATA2 ChEA Transcription Factor Targets 1.0 null serve GeneRIF Biological Term Annotations 1.0 null GTEX-S3XE-1826-SM-3K2B4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06178 ERGIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77213 LMBR1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28878 HCC78 DepMap CRISPR Gene Dependency 1.0 3.50478 Thyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 BRD-K54067431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03917 ABHD17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77244 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1135 opposed GeneRIF Biological Term Annotations 1.0 null CRCGN015_MCF10A_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6099 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966831 NCIH522 DepMap CRISPR Gene Dependency 1.0 2.05451 CRCGN015_MCF10A_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34988 cellular response to alcohol GO Biological Process Annotations 2023 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2919-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K93611325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41412 Supramolecular complex COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.805 ZNF628 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40601 outer SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.856746 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02008 multicellular organismal process GO Biological Process Annotations 2015 1.0 null intracellular monoatomic cation homeostasis GO Biological Process Annotations 2025 1.0 null NCIH1915 CCLE Cell Line Gene Expression Profiles 1.0 2.93857 c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K92791036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4426 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KELLY DepMap CRISPR Gene Dependency 1.0 2.51634 spanning component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.24424 SGK2 Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BD-A2L6-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4ND-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null monovalent inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null MAST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37231 RAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58959 BRD-K15977595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71331 Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.885731 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.31728 GSE213650_0_v_2_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null JHUEM3 CCLE Cell Line Gene Expression Profiles -1.0 -1.64304 URB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.061 CESS COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06566 Edema HuGE Navigator Gene-Phenotype Associations 1.0 null ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220459 GSE145990_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T6MO-0008-SM-4DM6T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950554 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14475 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null bronchoalveolar system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K36204977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35815 GSE102467_3_v_0_pazopanib_human RummaGEO Drug Perturbation Signatures 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55518 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25594 GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933551 RACK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92807 STAT3 ENCODE Transcription Factor Targets 1.0 null myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.182533 whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.225647 CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80615 GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null NUGC-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.55373 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.870377 BRD-A42433574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7969 TBC1D17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44925 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19429 PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS Rummagene Transcription Factor Associations 2026 1.0 null Cardiovascular Diseases HuGE Navigator Gene-Phenotype Associations 1.0 null RIDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5089 TCCSUP COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.42607 PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K96505704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13331 GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88294 BRD-K11905754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12853 Nephrogenic diabetes insipidus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.155 C22orf39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.791 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23114 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.324 anovel GeneRIF Biological Term Annotations 1.0 null Rhinencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.546 icSARA deltaORF6_60Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.277 ARID3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95479 HC-01-FD24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277231 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43309 LBH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76365 localization GO Biological Process Annotations 2015 1.0 null GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1702 RHOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92389 NECTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15783 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50431 PLCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18119 DANG CCLE Cell Line Gene Expression Profiles -1.0 -1.46195 RAB40C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93859 PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8 Rummagene Transcription Factor Associations 2026 1.0 null GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null rubella DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.820847 BRD-K46298577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.61754 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.07561 BRD-K71486446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19168 RBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55584 dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.895313 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10638 NIPA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68454 GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048047 TTC642 DepMap CRISPR Gene Dependency 1.0 3.19416 KPNRTBM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.37592 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.60077 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.0402 improved GeneRIF Biological Term Annotations 1.0 null PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.84305 TBP ENCODE Transcription Factor Targets 1.0 null Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CDCP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31721 enacdelta GeneRIF Biological Term Annotations 1.0 null BRD-K50815029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.58472 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.886469 asthenospermia GeneRIF Biological Term Annotations 1.0 null BRD-K37596331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02257 RPL27A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14839 GTEX-SNMC-1526-SM-2XCFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03996 BRD-K60895802 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67973 Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Apical plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K83684822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04813 SNU-407 COSMIC Cell Line Gene Mutation Profiles 1.0 null primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.65899 BRD-K08241590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01674 GSE188458_2_v_0_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25526 BRD-K35726223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42793 GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849457 GTEX-T5JW-0426-SM-4DM7M GTEx Tissue Sample Gene Expression Profiles 1.0 1.17622 TMCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09184 sodium ion transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null differences GeneRIF Biological Term Annotations 1.0 null BRD-K98465548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0834 BRD-K42663584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85499 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35567 BRD-K50884475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80824 BRD-K39824708 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45708 ALDH7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01295 LN18 BioGPS Cell Line Gene Expression Profiles -1.0 -1.076 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WU-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83721 ETS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08153 DDX3X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12084 BRD-K24825509 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.7021 primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31745 BRD-K33951208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2212 GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12157 POU2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.3009 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles 1.0 0.878775 IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6518 DAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11101 MEOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15308 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.50136 PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null NHEK Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.892553 Hypokalemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.475 CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.75298 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.7437 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.77446 PPP1R3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67825 Uterine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.733 deltasubunit GeneRIF Biological Term Annotations 1.0 null Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.069 NR5A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.42502 BRD-K54260552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00351 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 Vertebral hypersegmentation and orofacial anomalies DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.925636 TNFRSF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28016 GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 0.957241 ZNF626 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07412 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37273 YTHDF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65009 GTEX-WFG8-0626-SM-3GILJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862164 MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.883067 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12079 SARS-BatSRBD_0Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.9199 GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76781 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.79331 HEATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77979 GFPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44816 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CBX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35893 BRD-K71139459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03907 BRD-K28853245 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.007 SEC61B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53421 Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8449 SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58846 ZNF667 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4411 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CE-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sodium CTD Gene-Chemical Interactions 1.0 null PMC5109294-celldisc201641-s3.xls-NANOGP8_DEGs-Unnamed_10_NANOGP8 Rummagene Transcription Factor Associations 2026 1.0 null monastrol-311 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sperm GeneRIF Biological Term Annotations 1.0 null using GeneRIF Biological Term Annotations 1.0 null monoatomic cation channel activity GO Molecular Function Annotations 2025 1.0 null t47d HPA Cell Line Gene Expression Profiles 1.0 0.853805 ANKRD13C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55664 GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15845 striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.853806 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49703 Lung adenocarcinoma_LUAD_TCGA-93-A4JO-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC25A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4549 GTEX-T6MN-0011-R5A-SM-32QPD GTEx Tissue Sample Gene Expression Profiles 1.0 0.823952 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21755 Nasal mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 icSARS CoV_60Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.89019 Immune system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K56408846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11477 rectum_8a HPA Tissue Sample Gene Expression Profiles -1.0 -1.45229 BRD-A12372458 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39289 BRD-K32444429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30946 BRD-K40418847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47963 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K72565671 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32873 BRD-K36197756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38396 chemically GeneRIF Biological Term Annotations 1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33569 BRD-K59975583 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29341 connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04212 ubiquitination GeneRIF Biological Term Annotations 1.0 null H3C14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.526 NCIH650 CCLE Cell Line Gene Expression Profiles 1.0 1.36105 BRD-K40220562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09702 ELK4 JASPAR Predicted Transcription Factor Targets 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38929751 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71559 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61841 22RV1 DepMap CRISPR Gene Dependency 1.0 2.65385 POU5F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52164 CHD2_02_196 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.75174 BRD-K29475348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26957 BRD-K99000702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57034 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 BRD-K38766433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74193 NFYA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68629 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.241132 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8347 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17006 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4833-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K14098658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14976 Succinate dehydrogenase complex (ubiquinone) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.962 BRD-K98189856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15661 PMC10248509-Data_Sheet_5.CSV--GSE66724_DE-Genes_AND_GSE41177_DE-Genes_NOT_Autophagy_NOT_GSE58294_DE-genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.5978 MITD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.84647 CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50854 GSE115364_0_v_1_idh3a_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.60426 BRD-K97692908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60054 BRD-K66659401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18669 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288745 GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures 1.0 null IRX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09264 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KP3 DepMap CRISPR Gene Dependency 1.0 2.99387 CNOT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88225 THUMPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15321 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10181552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53581 Perturb_6410_KD_GLUD1_SRP166295 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 1.66836 CRCGN016_MCF10A.WT.HP_24H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.19755 transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SJRH30 GDSC Cell Line Gene Expression Profiles 1.0 2.31106 CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.85815 Transport of small molecules Reactome Pathways 2024 1.0 null GNAQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4069 CARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47477 GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15109 Prostate adenocarcinoma_PRAD_TCGA-V1-A8MG-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null single-multicellular organism process GO Biological Process Annotations 2015 1.0 null BRD-K10820981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19977 GTEX-RUSQ-0326-SM-47JWS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91815 smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.2451 ERI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60162 number GeneRIF Biological Term Annotations 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.497657 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03352 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.99998 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.857014 KKU100 DepMap CRISPR Gene Dependency 1.0 4.66892 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04704 Cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Mitochondrial inner membrane assembly complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.224 Ion channel transport Reactome Pathways 2014 1.0 null SH3GL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99623 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null ZBTB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34667 PER3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39762 Essential hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.144 BRD-K04834648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44878 MPND CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23914 sternum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.38665 COX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08691 FUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25218 HNF4G_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2565 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49315 ATG4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33137 intrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.101424 GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.57137 ATF7IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81306 CHP212 CCLE Cell Line Gene CNV Profiles -1.0 -1.64313 GSE231720,GSE231724_3_v_0_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.37771 BRD-K11566857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43337 donors GeneRIF Biological Term Annotations 1.0 null Throat TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.065 external GeneRIF Biological Term Annotations 1.0 null TMED8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35859 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.90034 KCTD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07083 ZBTB7A ENCODE Transcription Factor Targets 1.0 null HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.67961 hybridization GeneRIF Biological Term Annotations 1.0 null arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.953198 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83597 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.82205 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.48431 SCNN1G Pathway Commons Protein-Protein Interactions 1.0 null G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.3253 BRD-K83229680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93541 GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.10077 BRD-K92913380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02773 CL-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19007 analyses GeneRIF Biological Term Annotations 1.0 null PRR29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57714 GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23981 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.74692 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FU97 COSMIC Cell Line Gene Mutation Profiles 1.0 null Inflammatory bowel disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.688 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.256902 GSE226584,GSE226589_1_v_0_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T8EM-1826-SM-4DM7F GTEx Tissue Sample Gene Expression Profiles 1.0 0.864704 GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.63419 BRD-K25149224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43131 centrosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.200999 GSE210101,GSE210114_2_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null glioblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.107934 KLC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84727 BRD-K77237686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14439 SNU886 DepMap CRISPR Gene Dependency 1.0 2.46832 GTEX-XMD1-0011-R5A-SM-4AT47 GTEx Tissue Sample Gene Expression Profiles 1.0 0.859269 GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42961 Spleen Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.03731 SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.43893 brain_3b HPA Tissue Sample Gene Expression Profiles 1.0 0.851789 CRCGN014_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.97111 LRRC55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68409 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.338 account GeneRIF Biological Term Annotations 1.0 null interleukin-18 receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.937 HNF4A ENCODE Transcription Factor Targets 1.0 null sodium ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.934954 cellular response to aldosterone GO Biological Process Annotations 2023 1.0 null POU2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3988 BRD-K25805580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11087 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.82391 CTCF ENCODE Transcription Factor Targets 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.00693 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CALHM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44369 intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.074647 GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85966 strongly GeneRIF Biological Term Annotations 1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25648 NEK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95565 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50524 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09433 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0404 HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.542991 AGPAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.371 rectum_8d HPA Tissue Sample Gene Expression Profiles -1.0 -1.07164 MAP2K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69408 E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K94090114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57071 GTEX-WL46-2926-SM-3LK82 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00593 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K71194915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57861 ZBTB47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02828 NINJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87562 Nucleus preopticus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.667 PDGFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88412 Miliaria rubra DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.492 GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19486 KCTD15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33987 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null sodium ion import across plasma membrane GO Biological Process Annotations 2025 1.0 null BRD-K60729758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4628 Bronchiectasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null FAM193B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42225 Integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PMC8986528-41586_2022_4598_MOESM6_ESM.xlsx-Fig_4f-NOL9_KD_downreg_AR Rummagene Transcription Factor Associations 2026 1.0 null ZNF273 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71292 ETV3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61466 Lung adenocarcinoma_LUAD_TCGA-62-A46V-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF 10A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10989 PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null NKX2-6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09811 SLC25A36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28941 BRD-K24004917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05041