association dataset threshold value standardized value lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01975 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.997278 RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null BBS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13045 mRNA_SOX2_17515932 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.935476 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Metencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BT20 CCLE Cell Line Gene CNV Profiles 1.0 1.7835 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RN-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBXL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84608 hsa-miR-4673 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE233647_4_v_6_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.710383 NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00935 AA-46-GL76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.365584 GSE155830_1_v_0_fkbp5_mouse RummaGEO Gene Perturbation Signatures 1.0 null mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66227 dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.824637 GTEX-WL46-2926-SM-3LK82 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829395 ELF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAPAN1 CCLE Cell Line Gene CNV Profiles 1.0 1.76575 GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null SRA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04462 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35287 PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.95683 GSE161846,GSE161849_1_v_5_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE153189_1_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures -1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.026362 hsa-let-7f TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_15026_KD_KLF11_SRP267336 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.5187 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA42-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8428-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Sarcoma_SARC_TCGA-MJ-A68H-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1174 JUN_KO_GDS4205_294_mouse_B lymphoid cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NCOA2_KO_GSE41558_19_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE181959_1_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null bladder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null biosynthetic process GO Biological Process Annotations 2015 1.0 null IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.05778 DUSP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5503 duodenum HPA Tissue Gene Expression Profiles 1.0 0.830388 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6909-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE226355,GSE226357_2_v_0_ybx1_human RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23038 GSE202434,GSE202438_12_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null TEX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18246 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures -1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEX41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86157 Hypertrophy CTD Gene-Disease Associations 1.0 1.41396 GRPEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6885 ACHN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.874227 GSE178714_5_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE146612_1_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null PITX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81416 GSE87412,GSE92423_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.828138 intermediate stratum of p1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29192 GSE255432_6_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE224131_5_v_1_mafb_human RummaGEO Gene Perturbation Signatures -1.0 null PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -2.06113 HES6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1513 dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.418 oxidoreductase activity GO Molecular Function Annotations 2015 1.0 null GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE165308_1_v_0_gfi1_human RummaGEO Gene Perturbation Signatures -1.0 null Superior olivary complex, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25796 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VPS37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35111 GSE193258,GSE193259_9_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE230263,GSE230265_3_v_1_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null PAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23902 GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69733 SPTLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16303 Perturb_11270_KO_Bmal1_SRP337469 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.37998 HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.44986 nervous system disease GWASdb SNP-Disease Associations 1.0 0.048999 GSE130437_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QDT8-2926-SM-32PKC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 NVL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16408 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Entorhinal area, medial part, ventral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29963 Chloroplast thylakoid membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.695 epidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.5589 NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35265 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02246 hsa-miR-10b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r9 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08825 layer 5 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44811 TC-69-EY43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204947 Cerebellum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3444 Perturb_8355_KO_ZCCHC4_SRP345783 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.33365 GSE133516_5_v_2_kat7_human RummaGEO Gene Perturbation Signatures 1.0 null RADX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12743 GTEX-T5JC-0011-R5A-SM-32PLK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 hsa-miR-513c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 smallintestine_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.17411 Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61441 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5752-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPL-2426-SM-48TDN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE233679_6_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE ChEA Transcription Factor Targets 2022 1.0 null GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 OCIMY5 DepMap CRISPR Gene Dependency 1.0 3.84341 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.909568 GTEX-NPJ8-0011-R10A-SM-2YUMO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.924829 GTEX-U3ZN-1226-SM-4DXUD GTEx Tissue Sample Gene Expression Profiles 1.0 0.910703 Hypoplastic left heart syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.35 GSE186633_1_v_0_chd1_human RummaGEO Gene Perturbation Signatures -1.0 null EFO-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.853517 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-1026-SM-4GICL GTEx Tissue Sample Gene Expression Profiles 1.0 1.33173 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.914735 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.903412 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S341-1726-SM-3K2AK GTEx Tissue Sample Gene Expression Profiles 1.0 1.73418 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6825-01A-21R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4645-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE128730_7_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me1_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null SZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.850235 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-0126-SM-3NM95 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28322 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4709-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE189356_3_v_6_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957572 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.939345 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE214931_3_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q2AG-0126-SM-33HBV GTEx Tissue Sample Gene Expression Profiles 1.0 1.00278 NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07763 GSE129244_3_v_1_lmo2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE232714_0_v_1_raver1_human RummaGEO Gene Perturbation Signatures -1.0 null SRC-2_KO_GDS5087_485_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7CZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC2218 CCLE Cell Line Gene CNV Profiles -1.0 -1.66678 POU6F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0802 PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR Rummagene Transcription Factor Associations 2026 1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3133 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BI-01B-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basal reticular formation of p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01464 GSE175787_11_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null bed nucleus of the stria terminalis, laterocentral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26581 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75844 GSE148193_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_11105_KO_Tsc1/Depdc5_SRP219943 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE132948,GSE132949_2_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_9183_KD_RAB5C_SRP216516 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.08798 GTEX-XXEK-2226-SM-4BRUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.1437 Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-RNOR-1226-SM-48FDQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.866096 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838749 GSE173873_12_v_13_stra8_mouse RummaGEO Gene Perturbation Signatures 1.0 null EWSR1 ChEA Transcription Factor Targets 1.0 null GTEX-Q2AG-0011-R1A-SM-2HMJI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 umbilical cord blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35265 r9 part of the lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95153 TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4794 lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.86882 A-CA-04-2009(H1N1)_18Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.20785 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05346 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.14482 retrosplenial cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74328 SREBF1 JASPAR Predicted Transcription Factor Targets 1.0 null intermediate stratum of p2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15057 znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.055136 496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.925 REEP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01915 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE229468,GSE229471_2_v_1_znf587_human RummaGEO Gene Perturbation Signatures 1.0 null GSE184087_4_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null MM160113 DepMap CRISPR Gene Dependency 1.0 9.46534 Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.47629 Myelomonocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.924 striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44909 Lung adenocarcinoma_LUAD_TCGA-69-7764-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null single-organism metabolic process GO Biological Process Annotations 2015 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5084 molecular_function GO Molecular Function Annotations 2015 1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158975_0_v_1_spp1_human RummaGEO Gene Perturbation Signatures 1.0 null urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03405 Lung squamous cell carcinoma_LUSC_TCGA-22-0940-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE192513,GSE192515_2_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EXOSC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56847 ZNF174 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29444 GTEX-NPJ8-1926-SM-3MJGB GTEx Tissue Sample Gene Expression Profiles 1.0 1.30365 DPRX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4762 AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306247 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269617 ZEB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151612_4_v_11_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null MDA-MB-361 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6491-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_15547_KO_Ar_SRP069731 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 layer 4 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27204 Anterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05652 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09127 GTEX-S7SE-0011-R4A-SM-2XCDB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 TJP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16234 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE151782_6_v_5_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827503 NOTO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24262 GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MDAMB134VI CCLE Cell Line Gene CNV Profiles -1.0 -1.72634 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.939693 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.951051 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.36688 GSE157594_6_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWS6-2026-SM-2XCB5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06506 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HA-01B-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.467392 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dense body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.513 MTCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12343 mantle zone of PThE Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39226 GSE145639_1_v_6_adar_human RummaGEO Gene Perturbation Signatures -1.0 null EN COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE203072_2_v_3_rpl3l_mouse RummaGEO Gene Perturbation Signatures 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.17398 excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE210101,GSE210114_2_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.06836 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-107 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 EGR1 ENCODE Transcription Factor Targets 1.0 null KCIMOH1 DepMap CRISPR Gene Dependency 1.0 2.82715 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BA-84-WN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.548575 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6869-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null Chloroplast thylakoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.671 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 496100547_HIP_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00268 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-8262-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Microgametophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.765 OSC-20 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-P78B-1026-SM-3NMC4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01314 GTEX-R3RS-0126-SM-3GIJL GTEx Tissue Sample Gene Expression Profiles 1.0 1.76365 hsa-miR-629 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Perturb_2481_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE240896,GSE240899_10_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04239 brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.01074 hsa-miR-4684-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 HTR1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1147 PSMB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23032 GTEX-OHPM-0126-SM-2YUN9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08045 HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225913 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845483 Plastoglobule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.0 NFYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26457 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.686258 intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12864 mRNA_DLX3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE167224,GSE168147_3_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures -1.0 null GSE135030_3_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.386966 GSE60837_2_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null OB olfactory fiber layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.62034 Perturb_13964_KD_GFI1_SRP302850 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.53035 CCDC152 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61193 GTEX-RNOR-2326-SM-2TF4I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 FGD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00723 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.862757 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12423 GTEX-T6MN-0011-R1A-SM-32QOY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PMC8567280-EMBR-22-e53014-s007.xlsx-Sheet1-Nearest_genes_to_BAZ2A-bound_C2-Enhancers_BAZ2A Rummagene Transcription Factor Associations 2026 1.0 null 496100640_PCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.62012 GTEX-WI4N-1026-SM-3LK7N GTEx Tissue Sample Gene Expression Profiles 1.0 1.23925 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PRKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49671 GTEX-QDVJ-1726-SM-2I5FX GTEx Tissue Sample Gene Expression Profiles 1.0 1.23817 anteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06076 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7PM-0126-SM-4AD6S GTEx Tissue Sample Gene Expression Profiles 1.0 1.24198 AA-77-MP68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240181 GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Posterolateral visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5131 GTEX-WRHK-1426-SM-3MJF9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26951 GSE223893_4_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S7SE-0011-R1A-SM-2XCDE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE175787_13_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-Q2AI-1326-SM-2S1PL GTEx Tissue Sample Gene Expression Profiles 1.0 1.19329 SPPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14789 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178714_3_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null MUTZ8 DepMap CRISPR Gene Dependency 1.0 5.12993 GSE138019_1_v_2_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null Uvula (IX) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.2166 cas1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.548 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 hsa-miR-4650-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 LMO2-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2737-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.889072 GSE95826_4_v_1_tcra_mouse RummaGEO Gene Perturbation Signatures 1.0 null NETO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24295 H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dorsal peduncular area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.87465 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5329-01A-01R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WY7C-2326-SM-3NB2U GTEx Tissue Sample Gene Expression Profiles 1.0 1.26999 GSE202434,GSE202438_4_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851747 GSE149123,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null BC-00-YH62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230881 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.59826 GSE233049_1_v_3_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null Microsporangium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.163 GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04499 layer 1 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.20056 cytosol COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 TRPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10458 Perturb_15521_OE_proL1_SRP277452 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.4879 layer 6 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17352 NXPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65016 GSS CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 hsa-miR-4500 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 IMR32 CCLE Cell Line Gene CNV Profiles -1.0 -2.16771 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AMO1 DepMap CRISPR Gene Dependency 1.0 3.76505 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE237040_4_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13753 GTEX-WL46-0011-R10A-SM-3MJFQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null DOK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07595 ZNF239 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73922 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35265 GSE229468,GSE229471_0_v_1_znf587_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Perturb_9584_KO_Vdr_SRP115411 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.09027 iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.829528 OB granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12599 Perturb_11255_KO_Nr5a2_SRP131036 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.41189 Posterolateral visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18096 GA10 CCLE Cell Line Gene CNV Profiles 1.0 1.98578 ORC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06286 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831608 GSE207914_1_v_7_nudt7_mouse RummaGEO Gene Perturbation Signatures 1.0 null organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null superficial stratum of r8BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58336 GTEX-WHSB-1326-SM-3LK6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.30059 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.13724 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-0726-SM-33HBL GTEx Tissue Sample Gene Expression Profiles 1.0 1.24173 CDC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12183 ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15862 H2AFZ ENCODE Transcription Factor Targets 1.0 null GSE135030_3_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE178292_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 496100407_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38582 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A196-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-197 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.604052 NDUFB11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29329 ZNF98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03413 F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25784 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8317 r6 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04463 Brain - Cerebellar Hemisphere GTEx Tissue Gene Expression Profiles 2023 1.0 4.34337 MRPL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13105 cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE146612_1_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null BT20 CCLE Cell Line Gene Expression Profiles 1.0 2.50198 GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43853 GTEX-QVUS-0011-R9A-SM-3GIJA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r10 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06029 MET_knockout_259_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.27922 GSE157050,GSE157051_2_v_9_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Brain - Putamen (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 1.0 0.386059 GSE158632_3_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null GSE227592_6_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-3B-A9HQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE122101,GSE122103_3_v_4_ssu72_mouse RummaGEO Gene Perturbation Signatures -1.0 null E2A MotifMap Predicted Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3137 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Perturb_3734_OE_CDO1_SRP119438 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null CA-96-UO48_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237475 GSE147664_0_v_1_arid1b_mouse RummaGEO Gene Perturbation Signatures -1.0 null cytoplasmic part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 KPL1 CCLE Cell Line Gene CNV Profiles 1.0 1.36738 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07112 RAB3A_Mutation - D77G point mutation_GDS2482_702_mouse_Cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SNU738 CCLE Cell Line Gene CNV Profiles 1.0 1.51513 Perturb_2870_Mut_KEAP1_SRP404927 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PMC12549544-mmc2.xlsx-AA_D7_VS_D14-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WYJK-0526-SM-3NM8Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.873676 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.46316 H3K27me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_2485_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4IQ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RRP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32051 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RE-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27768 ZNF114 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23102 mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25475 cell part LOCATE Predicted Protein Localization Annotations 1.0 null peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-SUCS-1926-SM-32PM3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.59596 GSE165636_0_v_4_tofacitinib_human RummaGEO Drug Perturbation Signatures 1.0 null gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07003 GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45569 GSE146074_0_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.925779 MYC ChEA Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2929-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TE-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null basolateral amygdaloid nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49856 BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6834 GSE215086_5_v_0_batf_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.2783 UBB_KO_GDS3906_494_mouse_Testis - 21 Days GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14065 GSE77108_5_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.646979 ELF1 ENCODE Transcription Factor Targets 1.0 null GTEX-X8HC-2726-SM-46MUA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-1426-SM-447AC GTEx Tissue Sample Gene Expression Profiles 1.0 0.915862 GSE193258,GSE193259_5_v_8_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BBS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63317 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 TMEM170B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83099 GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE175787_5_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210101,GSE210114_6_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null LRR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30474 GTEX-WHWD-1826-SM-3LK6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.1072 TRUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35456 RUNX3 ENCODE Transcription Factor Targets 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827503 BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.853347 GTEX-OIZH-0126-SM-2HMIS GTEx Tissue Sample Gene Expression Profiles 1.0 1.75204 PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824363 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9me3_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CA-68-KG29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.54129 GSE193258,GSE193259_9_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U3-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878826 Lung adenocarcinoma_LUAD_TCGA-05-4249-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198434_1_v_0_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DE-01A-22R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles 1.0 2.62525 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0011-R4A-SM-32PLT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE232631_4_v_3_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GATA3-24758297-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null p1 part of the pararubral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52207 Perturb_15458_KD_TIP5_SRP198493 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.52348 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null prethalamic eminence Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39226 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11132 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_15442_KD_MED25_SRP212208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.10988 WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.719211 GSE57871_6_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-QVUS-0011-R4A-SM-3GAE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE135244_0_v_1_trdmt1_human RummaGEO Gene Perturbation Signatures -1.0 null RPRML CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50076 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Amyloplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.909 PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF Rummagene Transcription Factor Associations 2026 1.0 null GSE213219_0_v_1_st3gal3_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH1963 CCLE Cell Line Gene Expression Profiles 1.0 2.0242 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5883-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null adrenal gland GTEx Tissue Gene Expression Profiles -1.0 -0.89005 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lateral reticular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38109 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B2-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-11A-02R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null t67-small-intestine_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.62785 GTEX-QDVN-2026-SM-3GAEP GTEx Tissue Sample Gene Expression Profiles 1.0 1.17263 Perturb_2491_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PCNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28362 Frontal pole, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08175 ZNF384_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42414 GTEX-N7MT-0011-R2a-SM-2I3GI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE210655_3_v_4_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null TCF12_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NYAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.46866 H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_7_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860905 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.83817 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14537 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2429 DepMap CRISPR Gene Dependency 1.0 2.32483 CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-XV7Q-2526-SM-4BRV9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.906038 GTEX-NFK9-0226-SM-2HMKQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.32891 GSE240468_3_v_2_nfyc_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X5EB-1926-SM-4E3IW GTEx Tissue Sample Gene Expression Profiles 1.0 0.967875 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45O-01A-21R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHP212 CCLE Cell Line Gene CNV Profiles -1.0 -1.89874 GTEX-XPVG-2126-SM-4B667 GTEx Tissue Sample Gene Expression Profiles 1.0 0.918672 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.56741 LD-69-ZV56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232116 HOXB2::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3796 GSE233647_2_v_3_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.93937 G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05529 GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE76425_0_v_7_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-365 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 SEC63 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94623 GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-QVUS-0011-R1A-SM-3GAD2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 ZNF143 ENCODE Transcription Factor Targets 1.0 null hsa-miR-514b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE235066_4_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE151612_0_v_11_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2413 Perturb_1355_KO_circSCL38A1_SRP342299 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.682 KB-88-OR49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201353 BARHL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.8891 RUNX1-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE232558_0_v_2_fbxl12_human RummaGEO Gene Perturbation Signatures 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-OHPL-0126-SM-2HMJ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19963 GSE149035_1_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null fh1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.123 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_8_v_7_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null PYROXD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52218 layer 3 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01485 GF1B-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-5096 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 mesoderm TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null hsa-let-7a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE164463_3_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH1650 CCLE Cell Line Gene CNV Profiles 1.0 2.07069 GSE202434,GSE202438_13_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null AB-18-YN11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229087 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878826 JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4914 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE235701,GSE261434_0_v_1_enasidenib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857006 GSE154936_3_v_4_remdesivir_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-UTHO-0011-R4A-SM-3GIJP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04581 RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225443 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KU1919 CCLE Cell Line Gene CNV Profiles 1.0 1.37382 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-11A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2173 hsa-miR-526b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195559_8_v_9_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.42264 catalytic activity GO Molecular Function Annotations 2015 1.0 null GSE157777_2_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GA-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53283 GSE104022_3_v_7_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148066,GSE157787_2_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Midbrain central gray TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.862 Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.9899 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.29874 GSE221327_1_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Parataenial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30941 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 hsa-miR-4458 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE210842_3_v_1_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210101,GSE210114_8_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GSE215086_3_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94666 GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Perturb_9123_KD_NTRAS_ERP134408 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.05533 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE233679_14_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.971219 Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Infralimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.9829 NUP205 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30329 H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE193258,GSE193259_2_v_1_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null SMC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22118 H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE195743_1_v_4_lhx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827503 GSE178714_3_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE138019_3_v_6_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7160-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.869941 NKAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00547 posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.95621 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AF-73-ON54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246379 GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.23447 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10054 GSE175787_13_v_7_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_10229_OE_miR148a_SRP362328 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4651 Trunk TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DNAJB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34381 GTEX-U3ZM-1526-SM-3DB9D GTEx Tissue Sample Gene Expression Profiles 1.0 0.866005 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BACH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.9738 UMUC11 DepMap CRISPR Gene Dependency 1.0 2.2671 GSE232631_0_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE216326_2_v_0_sulodexide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE226249_5_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-548b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24086 ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.8785 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.028288 GTEX-SJXC-0126-SM-2XCFF GTEx Tissue Sample Gene Expression Profiles 1.0 1.41014 GSE178227_1_v_0_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U412-0426-SM-3DB9O GTEx Tissue Sample Gene Expression Profiles 1.0 1.41747 GSE247764_3_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BU-01A-31R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A3U7-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00441 ELK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02591 GSE132948,GSE132949_4_v_1_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null OVMIU DepMap CRISPR Gene Dependency 1.0 12.4911 single-organism biosynthetic process GO Biological Process Annotations 2015 1.0 null TMEM120B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24547 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GABPA ENCODE Transcription Factor Targets 1.0 null H3K9me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210101,GSE210114_0_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Friedreich ataxia 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.529 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.26564 abnormal coat/ hair morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-VJYA-0526-SM-4KL1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 ventromedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2701 FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3702 GTEX-RVPU-2226-SM-2XCAQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.4515 GTEX-N7MT-0011-R10A-SM-2I3E1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 mammary gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5467-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15941 EGR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3-beta hydroxysteroid dehydrogenase/isomerase InterPro Predicted Protein Domain Annotations 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE248883_0_v_1_shmt2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82962 CCDC117 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54138 GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE140936,GSE140938_2_v_1_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null GSE168233_0_v_1_setdb1_human RummaGEO Gene Perturbation Signatures 1.0 null SKBR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.50344 TAF1 ENCODE Transcription Factor Targets 1.0 null LONP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45774 GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of ZIC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01631 3-beta-hydroxy-delta5-steroid dehydrogenase activity GO Molecular Function Annotations 2015 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00736 Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-01A-21R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03198 GTEx Lung 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -5.748 KYO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.53583 GSE145215_2_v_1_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null OB glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89597 GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles 1.0 1.58732 ELF1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE187006_0_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-1271 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NC-27-AD53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230138 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4730-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TGIF2LX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.5217 GSE77108_8_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null Isl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.4297 GTEX-PVOW-0011-R3A-SM-32PKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 abnormal coat/ hair morphology IMPC Knockout Mouse Phenotypes 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null central amygdaloid nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26581 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.46316 hsa-let-7b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 KP-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null HC-01-FD24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.282621 GTEX-XOT4-0626-SM-4B66L GTEx Tissue Sample Gene Expression Profiles 1.0 1.21505 LAMTOR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38724 496100380_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.20737 GSE178227_1_v_2_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-UPJH-0326-SM-3GADU GTEx Tissue Sample Gene Expression Profiles 1.0 1.2382 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.0413 GSE122215,GSE122217_0_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null RRAGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21404 GEMIN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39549 cellular_component GO Cellular Component Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174701_5_v_3_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null C14orf119 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01437 GSE148692,GSE148695_2_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SEC61B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02483 SKNMC CCLE Cell Line Gene CNV Profiles -1.0 -1.53181 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.699368 GSE77108_0_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null IC-05-AW29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213844 GTEX-XMD1-0011-R9A-SM-4AT49 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-X261-0126-SM-3NMD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41205 B-lymphoblastoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.964 GTEX-XQ3S-1526-SM-4BOOC GTEx Tissue Sample Gene Expression Profiles 1.0 1.32497 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08344 DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.553394 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-0011-R4B-SM-4AT5C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures -1.0 null FOXO1::ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.2614 disease GWASdb SNP-Disease Associations 1.0 0.024051 hsa-miR-501-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GTEX-X4XX-0011-R5A-SM-46MWN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 ANKRD52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42349 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34814 GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836581 r6 part of ventral gigangocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07088 P2URK562 DepMap CRISPR Gene Dependency 1.0 6.50153 GSE132948,GSE132949_0_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X4EO-2926-SM-4E3JH GTEx Tissue Sample Gene Expression Profiles 1.0 1.39618 hsa-miR-4514 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE128730_3_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null NR1I2 ChEA Transcription Factor Targets 1.0 null GSE195559_6_v_1_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null fetus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-WYVS-1626-SM-3NM9R GTEx Tissue Sample Gene Expression Profiles 1.0 1.19126 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210655_3_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null LASP1NB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01796 GTEX-S341-2026-SM-2XCAA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.955 periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8555 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE131680_1_v_0_macroh2a1_human RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-SI-A71O-06A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 20068109-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 NMB DepMap CRISPR Gene Dependency 1.0 2.45086 GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T5JC-0011-R1A-SM-32PM6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 dementia GWASdb SNP-Disease Associations 1.0 0.352309 hsa-miR-562 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.901789 GSE130217_5_v_3_sesn2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SOX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8536 CHD2 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZN-0926-SM-4DXTU GTEx Tissue Sample Gene Expression Profiles 1.0 1.0415 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE139239_2_v_6_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827658 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.938244 intermediate stratum of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01128 mantle zone of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66553 VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.714877 Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17997 GSE119978,GSE180930_0_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 WSUNHL DepMap CRISPR Gene Dependency 1.0 3.52685 PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TMMY-0226-SM-33HBA GTEx Tissue Sample Gene Expression Profiles 1.0 1.51703 GSE151612_4_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WFG8-2226-SM-3GIL9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3677 GSE216538_7_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE157777_2_v_0_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XUZC-1626-SM-4BRVP GTEx Tissue Sample Gene Expression Profiles 1.0 0.939224 GSE218378_1_v_0_pbx1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE101239_5_v_6_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null membrane part GO Cellular Component Annotations 2015 1.0 null Primary somatosensory area, upper limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08264 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.962789 Ectopic pregnancy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 DK-MG COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 1.32021 GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TXNIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30746 PMC3500769-srep00875-s3.xls-PAX2-Time_1_PAX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCT 116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4371 MEIS1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBK-0126-SM-2YUND GTEx Tissue Sample Gene Expression Profiles 1.0 1.59833 Primary somatosensory area, mouth, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79171 placenta HPA Tissue Protein Expression Profiles 1.0 1.0149 superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15981 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.448587 GSE216538_0_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UPJH-0226-SM-3GADV GTEx Tissue Sample Gene Expression Profiles 1.0 1.68899 GSE175787_11_v_7_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE240386,GSE242143_8_v_6_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X261-0011-R10B-SM-4E3JT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67747 GTEX-XOTO-0726-SM-4B659 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21797 ZCCHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21413 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE144443_10_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-3921 TargetScan Predicted Conserved microRNA Targets 1.0 0.053794 SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0806 GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE157894_1_v_0_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null Posterolateral visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09505 GTEX-T5JW-0726-SM-4DM6D GTEx Tissue Sample Gene Expression Profiles 1.0 1.05399 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36169 GSE74528_0_v_1_trex2_mouse RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.984236 hsa-miR-98 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844298 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08294 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00736 Brain - Nucleus accumbens (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 1.0 1.43566 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.46316 dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8555 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55D-1126-SM-48FEB GTEx Tissue Sample Gene Expression Profiles 1.0 0.860524 H3K9me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4671-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 ME1 CCLE Cell Line Gene CNV Profiles -1.0 -2.05862 GSE165682_2_v_1_ptbp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE139239_1_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6112 GSE221327_4_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14065 GSE213228_2_v_3_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210655_3_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.1618 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5558-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE95685_4_v_5_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null SP2 ENCODE Transcription Factor Targets 1.0 null GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 AF-00-QK19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.605678 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.658827 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.927536 GSE232631_5_v_3_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null HBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14232 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO Molecular Function Annotations 2025 1.0 null VPS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04699 hsa-miR-608 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE48812_8_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GDAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38578 PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.545557 Spermatheca TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.576 striatum_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.81414 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.94731 GSE206729_5_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SE-0011-R10A-SM-2XCDF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP2K7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40412 EZH2 ENCODE Transcription Factor Targets 1.0 null GSE206729_5_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null SBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23003 GSE157555,GSE157556_5_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventral claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.97683 PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Influenza_B Cell Lymphocyte_GSE3203 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.87493 GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3371 GSE175787_4_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null thyroid gland HPA Tissue Protein Expression Profiles 1.0 1.70685 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 Embryonic structure TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-RM2N-1426-SM-2TF4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.11407 GTEX-T2IS-3026-SM-32QPM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 SNU1196 CCLE Cell Line Gene Expression Profiles 1.0 1.35967 PMC11903305-41586_2024_8507_MOESM3_ESM.xlsx-Table_S1_MAF-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null stomach HPA Tissue Protein Expression Profiles 1.0 1.0149 Umbilical cord blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE147056_0_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5461-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.234809 RNF167 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41261 GTEX-O5YW-0126-SM-3LK6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.879284 GTEX-P4QT-1826-SM-2S1NJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AA-86-YY62_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273052 GSE149901_2_v_0_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE114013,GSE114014_0_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null MRPS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62852 Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-1626-SM-4IHKT GTEx Tissue Sample Gene Expression Profiles 1.0 1.14016 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0126-SM-3DB83 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58375 GSE77108_0_v_2_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GSE175787_11_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null reticular formation of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50833 Liver Cirrhosis, Experimental DisGeNET Gene-Disease Associations 1.0 null GSE205540_2_v_3_phloridzin_mouse RummaGEO Drug Perturbation Signatures -1.0 null amygdalostriatal transition area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32797 GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 SARS-dORF6_24Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.60735 RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0703 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE131588,GSE131690_1_v_0_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QVJO-0011-R2A-SM-2S1QK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PMC8047323-Table_2.xlsx-LPS_PMMA_T24-GeneSymbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5526-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AB-33-EM56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.893392 BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.19553 PSMD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47751 GSE125219,GSE125221_3_v_8_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null PMC11799275-Table1.docx-5-GLI1_GLI1 Rummagene Transcription Factor Associations 2026 1.0 null Primary somatosensory area, mouth Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41627 HUH6 DepMap CRISPR Gene Dependency 1.0 6.91279 DDR1_knockdown_169_GSE39207 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.46422 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null Plastid thylakoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.665 Gli2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.0341 GSE57871_11_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE174701_1_v_6_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 19218430-TableS3 GeneSigDB Published Gene Signatures 1.0 null EC-01-PH79_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.294473 Perturb_11251_KO_Med13_SRP302233 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.32488 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5457-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23038 BC-33-BM51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.370109 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE243879_1_v_0_elapor1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE151612_4_v_3_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QEG4-0226-SM-2S1PY GTEx Tissue Sample Gene Expression Profiles 1.0 1.16431 GSE216540_10_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null HEY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3582 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47443 premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48184 GSE216988,GSE216989_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53747 arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20498 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.8683 AKT1_knockdown_43_GSE12291 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.77784 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08152 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Globus pallidus, internal segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51867 PITPNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60473 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.919615 496100418_TCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.79429 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_424_KD_EHF_SRP049988 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE210383_0_v_1_trim71_mouse RummaGEO Gene Perturbation Signatures -1.0 null Taenia tecta, dorsal part, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8555 lateral part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1526 Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201735_3_v_1_cdca7_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1527 Cryptorchidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 H3K27me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF639 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78935 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903235 GSE226285_2_v_1_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null PITHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51667 Primary visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12674 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06599 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5813 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11867 HCC70 CCLE Cell Line Gene CNV Profiles 1.0 1.37186 Lung adenocarcinoma_LUAD_TCGA-50-5932-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-0526-SM-4DM54 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18972 GSE88819_11_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE180147_0_v_1_itga5_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-216b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 oculomotor nucleus, main part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80685 steroid biosynthetic process GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11151_OE_Aeg1/Myc_SRP048459 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.01307 GSE120370_0_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null EXOSC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25352 GSE196117_1_v_7_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-96 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 CEBPA-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CCK-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null GSE157555,GSE157556_3_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE195559_6_v_5_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE235066_4_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.859863 GTEX-QDT8-0011-R10A-SM-32PKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEG5-0226-SM-2I5GI GTEx Tissue Sample Gene Expression Profiles 1.0 1.39093 GTEX-XPVG-2526-SM-4B66D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852244 GSE226249_2_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11715 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Lek TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.687 steroid metabolic process GO Biological Process Annotations 2015 1.0 null LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.428071 hsa-miR-4689 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Taenia tecta, dorsal part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24264 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.89424 CHLA10 DepMap CRISPR Gene Dependency 1.0 2.12562 GSE120612_6_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10487 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_12_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.9534 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18076 CDK2_knockdown_132_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.5718 MET_knockout_250_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.59001 hsa-miR-4651 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174701_1_v_0_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null artery TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PK1 CCLE Cell Line Gene Expression Profiles 1.0 1.46554 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13649_OE_miR27_SRP067253 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.92516 GSE242367_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Submedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54287 Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22543 GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845834 GSE210580_0_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0806 DLG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02653 CAPAN-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.15316 KDM1A_KD_GDS5055_367_mouse_adipose tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null morphological abnormality of the central nervous system GWASdb SNP-Phenotype Associations 1.0 0.075285 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.420587 GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles 1.0 1.75235 GSE157555,GSE157556_3_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839466 GTEX-P4QT-0126-SM-2I3FL GTEx Tissue Sample Gene Expression Profiles 1.0 1.057 GTEX-QMR6-0011-R10A-SM-32PKO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.42943 SMIM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21858 KRT18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04335 SIHA CCLE Cell Line Gene CNV Profiles 1.0 2.14683 Perturb_15386_KD_FGFRL1_SRP319157 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.26802 NCI-H1650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.848304 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58082 GTEX-WFJO-0826-SM-4LVM5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.915152 hsa-miR-301a TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 PMC6977700-aging-12-102667-s004..xlsx-Stage1-The_identified_3126_dysregulated_LmiRM-CTs_in_stage_1_of_MI_1_day_of_MI_using_our_method_MITF Rummagene Transcription Factor Associations 2026 1.0 null oculomotor nucleus, Edinger-Westphal subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68347 Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55E-0011-R8A-SM-2TC66 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Perturb_11171_KO_Tug1_SRP176442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.39409 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7046 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.07131 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.33593 superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05065 Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE240896,GSE240899_2_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null PAK1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97385 suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41021 GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 icSARS CoV_24Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.14218 GSE77108_8_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GB-73-QS80_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206362 GSE135030_11_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null Dorsal peduncular area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32989 GTEX-X4EP-0626-SM-3P621 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26609 AC-30-XU83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.316611 island of Calleja major Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2173 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ATP5F1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03247 H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE157050,GSE157051_2_v_4_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null RXR-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE233647_4_v_5_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.904386 GSE151612_0_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null NT5DC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5854 GSE57871_5_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37501 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02583 GSE88819_5_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE148066,GSE157787_2_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE101336_1_v_0_decitabine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE171269_1_v_4_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE114992,GSE114993_1_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0011-R1A-SM-3LK6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133516_0_v_2_kat7_human RummaGEO Gene Perturbation Signatures 1.0 null abnormality of nervous system morphology GWASdb SNP-Phenotype Associations 1.0 0.067231 GSE220520_3_v_4_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13686 GSE232631_5_v_1_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-O5YT-0126-SM-48TBW GTEx Tissue Sample Gene Expression Profiles 1.0 1.17492 methylphenidate_mus musculus_gpl11180_gse33619 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE88819_5_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PRAME CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17934 Primary somatosensory area, upper limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52017 GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05728 Main olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.19346 head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27313 hsa-miR-4653-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.059817 GSE48812_4_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZN-1626-SM-4DXTZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.06678 TBCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59519 OVCAR8 CCLE Cell Line Gene CNV Profiles -1.0 -2.43475 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35265 Perturb_9181_KD_RAB5C_SRP216516 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.75176 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23954 GSE87412,GSE92423_0_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE233647_4_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Alzheimer's disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 hsa-miR-4287 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE199899_1_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE96777,GSE96778_3_v_2_zbtb4_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE233679_12_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.951051 single-organism process GO Biological Process Annotations 2015 1.0 null PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XUJ4-1826-SM-4BOOU GTEx Tissue Sample Gene Expression Profiles 1.0 1.00569 Excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-130a TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 SAR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38779 hsa-miR-4509 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor GO Molecular Function Annotations 2015 1.0 null Perturb_3565_KD_BMI1_SRP297906 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.46844 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-1626-SM-4BRUZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.22622 GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10679662-mmc3.xlsx-NC-D3-ZEB2-Mutant-Downregulated-Unnamed_7_ZEB2 Rummagene Transcription Factor Associations 2026 1.0 null Breast Cancer_Mammary gland_GSE2528 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.91943 C11orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53885 FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7583 GTEX-PWO3-0011-R1A-SM-2I5EW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-S95S-1226-SM-4GICG GTEx Tissue Sample Gene Expression Profiles 1.0 1.05757 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9109_KD_STAT3_SRP363695 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.43942 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.9117 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_3_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0011 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Tetralogy of Fallot DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.17 integral component of membrane GO Cellular Component Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles 1.0 1.12691 Inner kinetochore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.501 SARS-CoV_24Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.73147 GSE126621,GSE126920_1_v_0_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1162 FAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14116 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11548 GSE133213_9_v_15_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE149123,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE226355,GSE226357_1_v_0_ybx1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NPJ7-0011-R5a-SM-33HBK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882119 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5987 intermediate stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04573 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49592 PMC10558344-mmc1.docx-3-ZNF670_ZNF670 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879643 Basolateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03362 GSE169697,GSE169725_1_v_4_prrx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UPCISCC116 DepMap CRISPR Gene Dependency 1.0 3.37822 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02526 GSE206729_2_v_0_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.998515 GSE126776_0_v_1_pelp1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T5JW-1626-SM-3GADZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.9503 Perturb_12540_KO|OE_FBXO11|FBXO11_SRP278534 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYJK-0126-SM-3NMAB GTEx Tissue Sample Gene Expression Profiles 1.0 1.07181 Anterior cingulate area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07197 GTEX-XAJ8-1426-SM-47JYM GTEx Tissue Sample Gene Expression Profiles 1.0 1.05865 GSE229468,GSE229471_0_v_3_znf587_human RummaGEO Gene Perturbation Signatures -1.0 null GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null OPM2 DepMap CRISPR Gene Dependency 1.0 3.53414 Perturb_8377_KD_MAGEA3_ERP120445 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r6 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85118 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lipid metabolic process GO Biological Process Annotations 2015 1.0 null SREBF1 ChEA Transcription Factor Targets 1.0 null GSE122101,GSE122103_3_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures -1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.440132 MAPK1_knockdown_131_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.9868 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VC-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Nearest_Ensembl_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825021 GSE202434,GSE202438_12_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Hypospadias DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.162 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66585 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JIMT1 CCLE Cell Line Gene CNV Profiles 1.0 1.3772 GSE151612_0_v_3_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE246053_1_v_2_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P4PP-0126-SM-3LK69 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01533 H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE182179_5_v_4_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GSE145790_0_v_1_bruceantin_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null rostral putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08052 intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PX-01A-51R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TPRG1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21875 GOTO COSMIC Cell Line Gene Mutation Profiles 1.0 null TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.59477 r8 part of lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46291 GSE144231_4_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE230573_1_v_0_dcaf1_human RummaGEO Gene Perturbation Signatures 1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2077 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.70996 GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null Tauopathy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 GSE214931_1_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE226249_2_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles 1.0 1.29413 Perturb_17215_KO_Izumo1r_SRP354764 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.01057 GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null lateral portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.892895 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882618 GTEX-Q2AG-0011-R4A-SM-2HMKA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05455 GSE237984_1_v_0_magi1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE175787_4_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.550593 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11983 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19876 GSE169697,GSE169725_0_v_5_prrx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE167224,GSE168147_1_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures -1.0 null striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.02977 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 NTPCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25157 GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 ESO51 DepMap CRISPR Gene Dependency 1.0 5.0312 TGIF2LY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8424 GSE116810_5_v_4_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null OB outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64805 medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53136 GTEX-SN8G-0126-SM-32PLI GTEx Tissue Sample Gene Expression Profiles 1.0 0.928318 anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.77845 GSE148510_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null medial parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.895309 r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94412 GTEX-S3XE-1726-SM-3K2AM GTEx Tissue Sample Gene Expression Profiles 1.0 1.34894 Perturb_3415_KO_Cdx2_SRP093647 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.3904 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-1826-SM-4BRUV GTEx Tissue Sample Gene Expression Profiles 1.0 1.04158 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7927818-AAC.01755-20-s0002.xlsx-Supplemental_Table_1-Supplemental_Table_1_List_of_significantly_altered_genes_in_MDMs_differentiated_in_the_presence_of_PrEP_FTC_v_No_Drug_TDF_v_No_Drug_FTC_v_TDF_SRY Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NL4W-0011-R9a-SM-2I3G1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-T2IS-0126-SM-4DM6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.1214 PPARA-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IPC298 DepMap CRISPR Gene Dependency 1.0 2.74194 GSE195559_6_v_9_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE157050,GSE157051_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE243683_0_v_1_s100a16_mouse RummaGEO Gene Perturbation Signatures -1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895655 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.46316 GTEX-S32W-2126-SM-2XCB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76734 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9516 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-0008-SM-4E3JL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 FLI1::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.1169 layer 2 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09878 neurodegenerative disease GWASdb SNP-Disease Associations 1.0 0.258599 GSE213228_2_v_5_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null Uterus GTEx Tissue Gene Expression Profiles 2023 1.0 0.535267 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-DX-A3UE-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE156708_1_v_0_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null GSE189683_3_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PTMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06516 primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.876366 SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45472 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13458 GTEX-WHSE-0011-R1A-SM-3P5ZK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848435 GSE238116_3_v_2_egr1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XAJ8-0826-SM-47JY6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37925 ELF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.402 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.38438 Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF175 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0386 GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Perturb_12997_KO_rs2431697_ERP121303 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.07175 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MT-1226-SM-2D7W4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE140937,GSE140938_1_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null layer 2 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.13351 KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.546032 ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3933 GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Feather TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.329 Lung adenocarcinoma_LUAD_TCGA-67-3774-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE57871_1_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null RUNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26024 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3YS-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48523 hsa-miR-489 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 SOCS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00165 Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92156 Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE167474_2_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null GSE138019_4_v_6_nudt12_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE233679_12_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE124048,GSE124067_1_v_0_irf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE135514_8_v_9_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null FSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11038 JHESOAD1 CCLE Cell Line Gene CNV Profiles 1.0 1.36934 mantle zone of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5615 GSE175787_8_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67156 Primary somatosensory area, unassigned, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02564 SSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55587 HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.470174 GSE156708_1_v_2_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null MCF7 CCLE Cell Line Gene Expression Profiles 1.0 1.53117 Anterior cingulate area, ventral part, 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62651 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44N-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RIC8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81628 H3K4me1_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE76771_2_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null TIGAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29755 Lung squamous cell carcinoma_LUSC_TCGA-18-3414-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE106661,GSE106665_2_v_3_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null thyroid_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.858028 Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-0011-R11A-SM-2HMKZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE242367_1_v_0_dpp9_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_10916_KO_Ghr_SRP269490 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.77109 PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KYSE520 CCLE Cell Line Gene CNV Profiles -1.0 -1.46384 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22467 central nervous system disease GWASdb SNP-Disease Associations 1.0 0.09112 RMUGS CCLE Cell Line Gene Expression Profiles 1.0 1.98351 TET2_KO_GDS4287_431_mouse_GMP - bone marrow progenitor population GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE74251_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135514_2_v_9_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4771 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.7378 Perturb_12538_KO_FBXO11_SRP278534 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-RVPV-0011-R3A-SM-2TF63 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.0164 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-XUYS-0126-SM-47JWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.42177 GSE96641_3_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE140936,GSE140938_0_v_1_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X4EP-0126-SM-3P5YV GTEx Tissue Sample Gene Expression Profiles 1.0 1.29586 Main olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68185 Primary somatosensory area, nose Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94624 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 E2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4518 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.938244 GTEX-QESD-1426-SM-2S1R9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.99884 NCIH838 CCLE Cell Line Gene CNV Profiles 1.0 2.55081 GSE213715_0_v_1_iqgap2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XBED-1926-SM-47JYP GTEx Tissue Sample Gene Expression Profiles 1.0 1.17671 digits BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 brain_3c HPA Tissue Sample Gene Expression Profiles -1.0 -1.08909 GDM1 CCLE Cell Line Gene CNV Profiles -1.0 -2.1488 Carcinoma, Hepatocellular_Hepatic Tissue_GSE2127 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.69139 Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE223893_1_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE157555,GSE157556_4_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XUW1-0926-SM-4BONX GTEx Tissue Sample Gene Expression Profiles 1.0 0.981553 GSE146074_9_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100420_PCx_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.85852 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3157-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE158431_2_v_3_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-618 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE165704_0_v_1_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE195663_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE175787_13_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15057 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 mantle zone of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03531 EGR1 ChEA Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BF-01B-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JW-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Breast TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-TMZS-0126-SM-3DB9Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.931884 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49664 WC-59-RG09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305463 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GTEX-X88G-0126-SM-47JZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47157 GSE210101,GSE210114_5_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R3RS-1326-SM-48FE7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831216 TE15 CCLE Cell Line Gene Expression Profiles 1.0 1.50501 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null 59M DepMap CRISPR Gene Dependency 1.0 2.01725 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861119 GSE158458_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-TSE9-3026-SM-3DB76 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE184087_2_v_1_tert_human RummaGEO Gene Perturbation Signatures 1.0 null KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.435696 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE217363_4_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3297 PLK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00114 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CNPY4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38773 PNMA8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54302 skin_6a HPA Tissue Sample Gene Expression Profiles 1.0 0.919521 GH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66698 GTEX-X62O-0126-SM-4E3JN GTEx Tissue Sample Gene Expression Profiles 1.0 0.892038 WIPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54211 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28907 UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264965 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20857 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5630-01A-01R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03716 hsa-let-7g TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUJ4-2426-SM-4BOO3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38318 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853671 GSE159728,GSE159730_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356568 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00935 embryo TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null periventricular stratum of m1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00754 EFE184 DepMap CRISPR Gene Dependency 1.0 4.56612 Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215086_4_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210101,GSE210114_8_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GSE96641_5_v_2_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4715 GTEX-OXRN-0126-SM-48TDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.66446 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UTHO-0011-R3A-SM-3GIK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 diethylstilbestrol_mus musculus_gpl81_gse1839 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882618 FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.359627 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48097 Npas4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.8789 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23037 GSE230744,GSE237803_0_v_2_hira_human RummaGEO Gene Perturbation Signatures -1.0 null GSE175787_4_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CA-42-YI34_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.408446 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879643 GSE210476_2_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1079-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-454 TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37907 VEZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.8709 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0226-SM-2XCEU GTEx Tissue Sample Gene Expression Profiles 1.0 1.45828 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50833 TE4 CCLE Cell Line Gene Expression Profiles 1.0 1.68798 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100458_FWM_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06383 GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858553 GSE146687_2_v_6_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHST15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49159 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.403678 Prostate adenocarcinoma_PRAD_TCGA-CH-5761-11A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-SYMBOL_DBP Rummagene Transcription Factor Associations 2026 1.0 null FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3538 IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9693 BLOC-1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.637 Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00754 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF2F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22265 GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 ventromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21306 Neurodegenerative disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 GSE206516,GSE206518_1_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.4649 D2HGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40748 hsa-let-7e TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MED19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16759 GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_2488_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-U8T8-0126-SM-3DB94 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34923 GTEX-WYBS-0626-SM-3NMAS GTEx Tissue Sample Gene Expression Profiles 1.0 1.71852 496100502_TCx_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.28235 GTEX-Q2AH-1626-SM-3GAF8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44996 GSE149901_3_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.369288 MYLK_knockdown_48_GSE14525 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.70043 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Perturb_12539_KO|OE_FBXO11|FBXO11_SRP278534 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.2122 striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.68555 Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10444 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COL7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05466 ELK1::HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2293 HCC2814 CCLE Cell Line Gene Expression Profiles 1.0 1.49935 GTEX-R55G-2526-SM-2TC6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.853694 S117 CCLE Cell Line Gene CNV Profiles -1.0 -1.72819 GTEX-QLQW-1126-SM-2S1Q8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02567 DF-53-QT23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201386 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null TTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58584 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE70499_3_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8312-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skin_5f HPA Tissue Sample Gene Expression Profiles 1.0 1.88198 GNA12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70579 GTEX-UTHO-0011-R1A-SM-3GIJO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LC-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21083 GTEX-PWO3-0011-R2A-SM-2S1OX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882618 r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25514 GTEX-WH7G-2026-SM-3NMBL GTEx Tissue Sample Gene Expression Profiles 1.0 1.19069 GSE221327_1_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null C14orf93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86564 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-4716-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19869 GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852314 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897455 GTEX-QVUS-0011-R10A-SM-3GIK3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 BL1309 (WRN) NURSA Protein Complexes 1.0 null hsa-miR-4694-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF410 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9181 Lung squamous cell carcinoma_LUSC_TCGA-60-2708-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10724 GSE70499_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-W5X1-2526-SM-3GILC GTEx Tissue Sample Gene Expression Profiles 1.0 1.32239 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4863-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.31785 organic substance biosynthetic process GO Biological Process Annotations 2015 1.0 null GTEX-XMD1-0011-R3B-SM-4AT5R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE122425_1_v_0_nsun2_human RummaGEO Gene Perturbation Signatures -1.0 null ventral lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13604 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.443451 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 GSE227592_6_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GSE237040_4_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08463 RSV-A2_24Hour-B6.129PF1_J_None_GSE18170 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.22159 transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00582 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-WWYW-3126-SM-3NB39 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827834 mantle zone of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41672 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE232631_5_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XQ8I-0926-SM-4BOOF GTEx Tissue Sample Gene Expression Profiles 1.0 1.02274 Plastid thylakoid membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.693 PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_CAMTA1_vs_subEV-Gene_CAMTA1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of p1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12993 GSE134615_1_v_0_lats1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null nucleus of the stria medullaris (prethalamic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39226 PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_1_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE135350_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_16574_KO_Grn_SRP070944 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.66178 H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EGR1-23403033-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-1726-SM-4DXUQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.911329 GATA1-19941827-MEL86-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F3-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of p2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1737 GTEX-NPJ7-0011-R1a-SM-3GACT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE175787_11_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null BNC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10089 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GS-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null cetuximab_homo sapiens_gpl570_gse21483 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25514 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262289 GSE101239_5_v_1_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null CEBPB ChEA Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ERF::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9097 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.841192 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null HARBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45938 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42C-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.48043 H3K9me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X8HC-0626-SM-4E3HQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17131 stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.872747 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 IM9 DepMap CRISPR Gene Dependency 1.0 5.38229 OCILY18 DepMap CRISPR Gene Dependency 1.0 2.4818 GSE132948,GSE132949_2_v_5_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE239844_7_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null CBLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4833 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.21512 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17374 hsa-miR-301b TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 GSE164135,GSE164137_0_v_1_fbxw7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE153189_2_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05224 COGE352 DepMap CRISPR Gene Dependency 1.0 2.22857 GSE183413_0_v_2_ash1l_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null BE-38-UW72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232264 GSE125219,GSE125221_3_v_0_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5373-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10929187-ijbsv20p1547s4.xlsx-JQ1-dep_ATF4-XBP1signature-ABCC9_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null AP1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20651 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300993 GTEX-SIU8-0126-SM-2XCDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.22809 GSE202434,GSE202438_8_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAPRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38456 GSE145639_7_v_4_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, mouth, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.19866 tauopathy GWASdb SNP-Disease Associations 1.0 0.598827 NC-27-AD53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213507 GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-V1D1-2226-SM-3NMAX GTEx Tissue Sample Gene Expression Profiles 1.0 1.35299 GTEX-WVLH-0011-R10A-SM-3MJFM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830008 intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57964 GSE230744,GSE237803_0_v_3_hira_human RummaGEO Gene Perturbation Signatures -1.0 null Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56753 GTEX-U3ZH-0926-SM-4DXU4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.893535 GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH322 CCLE Cell Line Gene CNV Profiles 1.0 1.4708 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.02035 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33658 dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19295 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE211126_1_v_0_hapln1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE181821_1_v_3_mov10_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X4XX-0126-SM-3NMC2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31647 YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.567437 fat_8b HPA Tissue Sample Gene Expression Profiles -1.0 -0.963061 SOX9 ChEA Transcription Factor Targets 1.0 null PMC5792454-mmc2.xlsx-Table_S5-Table_S5_Genes_up_or_down_regulated_in_murine_Hoxa9_IRX3_leukemias_versus_Hoxa9_MTV_leukemias_Gene_Ontology_annotations_IRX3 Rummagene Transcription Factor Associations 2026 1.0 null GSE202434,GSE202438_6_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH209 CCLE Cell Line Gene Expression Profiles 1.0 1.37982 SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63373 PMC8185471-mmc4.xlsx-hESC-DEGs_between_SOX15_KO_hESCs_and_WT_hESCs_cells_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null striatum_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.33334 Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T6MO-1226-SM-4DM5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.960328 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF143 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.53936 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04624 GSE133070_3_v_1_prss1_mouse RummaGEO Gene Perturbation Signatures -1.0 null WDR86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17967 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.77734 CCDC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51726 GSE110248_1_v_6_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null intermediate part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41585 GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-RNOR-0126-SM-2TF57 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0159 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844486 GSE132948,GSE132949_4_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null 496100497_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.62467 H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Arcopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.903 SK-MEL-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4579 Infralimbic area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4061 H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KARPAS422 DepMap CRISPR Gene Dependency 1.0 3.44752 RAPGEFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52986 caudate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50833 GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19338 CAPAN1 CCLE Cell Line Gene Expression Profiles 1.0 2.03733 Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15001 GTEX-T8EM-1026-SM-3DB7M GTEx Tissue Sample Gene Expression Profiles 1.0 1.54443 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37504 Perturb_16479_OE_Klk6_SRP245408 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GSE172016_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273098 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.718576 GSE114992,GSE114993_4_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE255432_4_v_3_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Organism form TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Entorhinal area, medial part, ventral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15666 placenta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE211474,GSE212779_8_v_2_phf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878826 GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.98383 Ventral posteromedial nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8555 Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3938679-pone.0090284.s007.pdf-2-STAT3_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRN-0011-R5A-SM-2I5EF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 RLF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15667 GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860074 GTEX-QDVN-2426-SM-2S1Q4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 KYM1 DepMap CRISPR Gene Dependency 1.0 2.97988 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29735 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE174498,GSE174500_3_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null olfactory bulb, principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56057 GTEX-N7MT-1926-SM-3LK5N GTEx Tissue Sample Gene Expression Profiles 1.0 1.09367 Bladder TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GOLM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93431 hsa-miR-3617 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41574 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 RPP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44798 GSE193258,GSE193259_9_v_0_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XOTO-0126-SM-4B66N GTEx Tissue Sample Gene Expression Profiles 1.0 1.06096 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null Adrenocortical carcinoma_ACC_TCGA-OU-A5PI-01A-12R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157594_3_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null snoutepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19735 GTEX-PWCY-1726-SM-48TD3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.918161 Primary somatosensory area, upper limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48182 PTK7_knockdown_185_GSE50138 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.16731 IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.5707 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0011-R4B-SM-46MWL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VK-01A-21R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03405 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63471 GTEX-RNOR-2226-SM-2TF5O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01975 lung BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.33755 H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE206516,GSE206518_2_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null Brain stem TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7337-01A-21R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.933923 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.868511 BCAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27404 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BUD23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07449 Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174498,GSE174500_3_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null GSE220813_0_v_1_zfp750_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_0_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null connecting stalk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6563 CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22381 GTEX-S341-1926-SM-3K2BA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.44559 Nemaline Myopathy_Gastrocnemius Muscle_GSE3384 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.34555 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Main olfactory bulb, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67946 GSE173873_1_v_3_stra8_mouse RummaGEO Gene Perturbation Signatures 1.0 null reticular formation of p2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15057 Perturb_2480_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2 Rummagene Transcription Factor Associations 2026 1.0 null CDK7_knockdown_138_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.91911 FAM124A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82174 Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE233679_5_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null KRBA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24491 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE169334,GSE169336_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null periventricular stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08697 GCH1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.958 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 0.955852 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-0126-SM-2I3FK GTEx Tissue Sample Gene Expression Profiles 1.0 1.11499 GTF3C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38136 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4865-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-617 TargetScan Predicted Conserved microRNA Targets 1.0 0.187098 Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14917 superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00972 NR1I2-20693526-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null YY2_01_19 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61598 GSE240896,GSE240899_2_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null BTAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.39635 Fetal Kidney Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.18209 NSDHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02573 Perturb_14214_KO_App_SRP254653 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.64432 mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null DDX46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14252 Bhlha15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.2761 CLDN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78451 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02246 REC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.33253 NAD(P)-binding domain InterPro Predicted Protein Domain Annotations 1.0 null DDX60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73623 GTEX-OHPK-2526-SM-3MJH9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02891 SKMEL3 CCLE Cell Line Gene CNV Profiles -1.0 -1.41072 MATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44266 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01251 GSE208350_0_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.922978 hsa-let-7c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.60992 GTEX-OXRK-1326-SM-3NB1A GTEx Tissue Sample Gene Expression Profiles 1.0 0.878635 PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 striatum_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23036 GSE179974_3_v_0_carboplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE227592_13_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GSE77108_8_v_2_saha_human RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A901-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FUBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1561 Urinary bladder TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCIH1395 CCLE Cell Line Gene Expression Profiles 1.0 1.38301 647V CCLE Cell Line Gene Expression Profiles 1.0 1.38271 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ZNF747 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92981 GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41672 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.33603 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02127 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-X585-0011-R10A-SM-46MUY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04201 GTEX-X8HC-0126-SM-4E3JW GTEx Tissue Sample Gene Expression Profiles 1.0 1.25259 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE132694,GSE132717_0_v_2_meis1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE76771_1_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE145215_2_v_3_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null BD-69-XG81_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222855 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_399_KO_NFE2L1_SRP333364 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.96613 GTEX-NPJ8-0126-SM-2YUNR GTEx Tissue Sample Gene Expression Profiles 1.0 1.53583 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-641 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GTEX-X585-0011-R3B-SM-46MVG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Mammary gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ARMC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67096 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null H3K9me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE161846,GSE161849_4_v_0_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-WFON-1926-SM-3LK7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.05635 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33115 GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32993 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-0011-R4A-SM-2TC5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877472 GSE202434,GSE202438_9_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE101336_1_v_3_decitabine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T6MO-1626-SM-32QOM GTEx Tissue Sample Gene Expression Profiles 1.0 1.31218 H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE238018_1_v_0_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE216540_1_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null CF-50-QK79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207206 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12423 GSE233679_5_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null SNU503 CCLE Cell Line Gene CNV Profiles 1.0 1.47299 GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Hypertrophy, Left Ventricular_Myocardial tissue_GSE2459 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.33732 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE213650_0_v_1_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null GSE240386,GSE242143_8_v_4_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null BICR10 COSMIC Cell Line Gene Mutation Profiles 1.0 null CAMK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4284 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE138019_1_v_5_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABARAPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2442 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4884 GSE158458_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WHSE-0011-R8A-SM-3P5Z1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831315 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.0436 GSE148695,GSE167284_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null RPS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12909 GSE175787_11_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE128730_3_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null bladder TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.64132 GSE146074_9_v_11_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null CDK4_knockdown_133_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.83554 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_18Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.40838 GTEX-XBED-2226-SM-47JYQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.50741 Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZH-1926-SM-4DXTR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UJHI-0008-SM-4IHL1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 LGALS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07241 ABCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73351 H3K9me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4949 zona incerta complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01631 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-T2IS-0011-R3A-SM-32QPB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 CC-61-HH09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203959 Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171269_1_v_0_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null NDUFB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47419 Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood vessel TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCI-H1770 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null breast TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.03072 vascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null AC-47-YZ27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.396169 GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R55D-0008-SM-48FEV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 TNKS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61992 Kdm1a_KD_GDS5055_274_mouse_3T3-L1 preadipocytes - 24h GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-188-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.982889 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TMEM267 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29342 Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PSDG-0226-SM-33HC1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.68051 GSE114883_1_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null lipid biosynthetic process GO Biological Process Annotations 2015 1.0 null H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.881523 GSE178532_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V1D1-2026-SM-3GAF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38488 NUS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56068 PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab6_KDM5C-KD-up_genes-Table_6_Up_regulated_genes_in_KDM5C-KD_KDM5C-KD1_Control_overlap_KDM5C-KD2_Control_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X4EO-0326-SM-3P5YO GTEx Tissue Sample Gene Expression Profiles 1.0 1.23847 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.80982 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WQUQ-0426-SM-3MJFU GTEx Tissue Sample Gene Expression Profiles 1.0 1.54543 OC-10-FB51_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232912 VTI1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13039 AKT2_knockdown_44_GSE12291 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.67604 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10444 mantle zone of ZIC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01802 Sarcoma_SARC_TCGA-DX-A6B9-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.76977 GSE112860_0_v_2_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null GTEX-WEY5-2326-SM-3GIKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.01714 Lung adenocarcinoma_LUAD_TCGA-49-4501-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157594_5_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RN64-0126-SM-2TC68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03996 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02363 Infundibular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.713 GTEX-UPK5-0426-SM-3GAEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.16667 GSE48812_3_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCIH358 CCLE Cell Line Gene CNV Profiles 1.0 1.55035 GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE142210_9_v_10_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null NADP CTD Gene-Chemical Interactions 1.0 null GSE90552_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE124375_10_v_9_chd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.1181 MDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38314 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE85880,GSE85881_0_v_1_tretinoin_human RummaGEO Drug Perturbation Signatures 1.0 null FE-64-KC49_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286141 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null subthalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.881644 hsa-miR-4295 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KQ-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211474,GSE212779_8_v_4_phf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null JB-75-NC66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227898 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null hsa-miR-4753-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 H2AC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04053 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB-06-WW76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.387271 SPINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19239 GTEX-W5WG-1826-SM-4KL2Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.28961 PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-1526-SM-48TCM GTEx Tissue Sample Gene Expression Profiles 1.0 1.60854 GSE116810_5_v_3_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null KDM4C_natural variation_GSE41040_590_human_fibroblasts fron neonatal foreskin GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE237040_6_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Sarcoma_SARC_TCGA-X6-A7WD-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE195663_7_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4598 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15921 Lung adenocarcinoma_LUAD_TCGA-38-4628-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE176093_2_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K9me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33181 H2461 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE152246_0_v_1_dihydrotestosterone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE148066,GSE157787_8_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NZOV9 DepMap CRISPR Gene Dependency 1.0 2.39059 CPHXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34323 GSE168401_1_v_3_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null EMX2_Deficiency_GDS3173_607_mouse_Embryonic urogenital epithelium - day 10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2928-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE227592_4_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null EBC1 CCLE Cell Line Gene CNV Profiles 1.0 1.73821 GSE178714_6_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Brain - Hippocampus GTEx Tissue Gene Expression Profiles 2023 1.0 4.22651 GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.45977 GTEX-X4XX-0011-R3B-SM-46MWK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE145311_0_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE175787_8_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7789 GSE128730_7_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157049,GSE157051_6_v_4_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null dorsal part of alar p3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38957 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral zona incerta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01464 PMC12224833-12967_2025_6787_MOESM3_ESM.xlsx-DEGs_PDX1-GeneSymbol_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null HCC1954 CCLE Cell Line Gene Expression Profiles 1.0 1.50958 DSN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56553 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.840683 Lung adenocarcinoma_LUAD_TCGA-05-5715-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE227592_10_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-466 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-0126-SM-48FCK GTEx Tissue Sample Gene Expression Profiles 1.0 1.17228 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-SNMC-0826-SM-4DM66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.861127 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GOLGA8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3003 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.824896 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE68925_1_v_0_fasudil_human RummaGEO Drug Perturbation Signatures -1.0 null EIF3M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48352 SURF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62805 BC3C CCLE Cell Line Gene CNV Profiles 1.0 1.45406 SUGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56486 GTEX-XYKS-2126-SM-4E3IB GTEx Tissue Sample Gene Expression Profiles 1.0 1.4505 PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66227 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11622 pararubral nucleus, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26581 DYRK1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55802 GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.24141 GSE119978,GSE180930_6_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QV44-1926-SM-2S1RF GTEx Tissue Sample Gene Expression Profiles 1.0 1.20008 KIF26A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10863 GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12864 KMS26 CCLE Cell Line Gene CNV Profiles 1.0 3.27131 GTEX-RWSA-0126-SM-2XCBB GTEx Tissue Sample Gene Expression Profiles 1.0 1.19378 GTEX-S7SE-0126-SM-2XCD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35273 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66227 H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.951051 FERD3L JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.4262 SNAP29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32333 alzheimer disease GWASdb SNP-Phenotype Associations 1.0 0.508699 Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.93853 GSE148066,GSE157787_3_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24378 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null germ layer TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-TML8-1926-SM-32QOS GTEx Tissue Sample Gene Expression Profiles 1.0 1.41664 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.940403 NADK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09702 NCI-H1355 COSMIC Cell Line Gene Mutation Profiles 1.0 null DAN-G COSMIC Cell Line Gene Mutation Profiles 1.0 null duodenum_4b HPA Tissue Sample Gene Expression Profiles 1.0 0.99428 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Main olfactory bulb, inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51442 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028307 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T2IS-0011-R2A-SM-32QPF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826896 GTEX-NPJ8-0011-R2a-SM-2TC6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 RRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33418 GSE147626_2_v_1_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_8019_KO_Cblif_ERP002279 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 periventricular stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26806 Ventilator-associated lung injury_Lung Tissue_GSE2411 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.50253 ELK1 ENCODE Transcription Factor Targets 1.0 null GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 496100367_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.7182 m1B part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00754 GSE60837_2_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RU1J-1926-SM-2TF6S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 9505BIK DepMap CRISPR Gene Dependency 1.0 2.20333 urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20616 TP53 JASPAR Predicted Transcription Factor Targets 1.0 null GSE239688_4_v_0_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 3 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15433 VPS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47307 GTEX-XK95-0226-SM-4AT58 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18093 GSE241036_4_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QMR6-0011-R1A-SM-32PKW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 ventral posterior parvicellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.44133 brain HPA Tissue Gene Expression Profiles -1.0 -1.20119 GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835651 lateral hypothalamic area, tuberal part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03614 SREBP1-19666523-LIVER-FROM-C57BL-MICE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GB-73-QS80_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.30353 intermediate stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59844 JHUEM1 DepMap CRISPR Gene Dependency 1.0 4.30501 Primary somatosensory area, unassigned, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43974 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MLXIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24532 microbody LOCATE Predicted Protein Localization Annotations 1.0 null Perturb_9107_KD_G6PD_SRP287480 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.81737 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27046 GSE218879_1_v_2_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XX-0011-R1B-SM-3P622 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-QVJO-1426-SM-2S1QY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 BCLAF1 ENCODE Transcription Factor Targets 1.0 null Main olfactory bulb, granule layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01746 Perturb_429_KD_EHF_SRP049988 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MDAMB157 CCLE Cell Line Gene CNV Profiles -1.0 -2.03078 SNU1214 CCLE Cell Line Gene Expression Profiles 1.0 1.46777 PMC3500769-srep00875-s3.xls-GATA3-Time_1_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-874 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE166004_3_v_6_pld1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HERPUD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06132 GTEX-OXRN-1326-SM-3LK5V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832259 Lung squamous cell carcinoma_LUSC_TCGA-56-1622-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_2_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55034 Cystic Fibrosis_Pancreas_GSE769 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.09825 GTEX-X585-3026-SM-46MWF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.886473 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE85880,GSE85881_4_v_2_tretinoin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE216538_1_v_6_mrs2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE145639_7_v_2_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RU72-0926-SM-2TF6B GTEx Tissue Sample Gene Expression Profiles 1.0 0.918031 GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Perturb_8061_KO_ZCCHC4_SRP350212 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.9401 OSBPL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65349 GSE88819_5_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TRAF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84295 RMI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41829 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.933669 SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10219 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5703-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXB4 ChEA Transcription Factor Targets 1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00736 GSE168596_1_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02545 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urinary bladder TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null OB mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45163 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSDMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02334 GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WHSE-3026-SM-3P5ZH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879643 GSE110178_4_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE145215_0_v_3_krt13_mouse RummaGEO Gene Perturbation Signatures -1.0 null SA-03-IQ14_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237049 ERF::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5492 Ventral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06449 GTEX-T6MN-2626-SM-32PMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 IRF6_KO_GDS2359_126_mouse_skin E17.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-P4PQ-0126-SM-2S1NM GTEx Tissue Sample Gene Expression Profiles 1.0 0.848271 mRNA_POU5F1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null NB6 DepMap CRISPR Gene Dependency 1.0 2.03785 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10042 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE96777,GSE96778_1_v_0_zbtb4_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XMD1-0011-R10A-SM-4AT4A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 POR_KO_GDS1678_760_mouse_Colon GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-QDT8-0011-R3A-SM-32PKR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880232 intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor GO Molecular Function Annotations 2015 1.0 null GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.87268 GSE133070_2_v_4_prss1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.2957 QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215849 EWS-ERG-20517297-CADO-ES1-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ADAM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59274 hsa-miR-766 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1422 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE237040_0_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE96641_1_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-X6-A8C7-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226285_2_v_1_nr0b1_human RummaGEO Gene Perturbation Signatures 1.0 null MM383 DepMap CRISPR Gene Dependency 1.0 4.22813 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-XLM4-0011-R10A-SM-4AT5P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 496100469_TCx_no dementia_TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.79621 OMC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-3194-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 pancreas HPA Tissue Protein Expression Profiles 1.0 1.0149 Infection by Yersinia enterocolitica_macrophage_GSE2973 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.32472 GTEX-WH7G-2326-SM-3NMBC GTEx Tissue Sample Gene Expression Profiles 1.0 0.891289 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null LPS6 DepMap CRISPR Gene Dependency 1.0 2.04583 GTEX-S3XE-1226-SM-4AD4L GTEx Tissue Sample Gene Expression Profiles 1.0 0.872283 SRPK2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null oxidation-reduction process GO Biological Process Annotations 2015 1.0 null GTEX-UTHO-0011-R2A-SM-3GIKC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 FRS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12802 GSE202434,GSE202438_4_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Anterior cingulate area, ventral part, 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03893 GTEX-RU72-0726-SM-46MUW GTEx Tissue Sample Gene Expression Profiles 1.0 0.86309 JIMT1 CCLE Cell Line Gene Expression Profiles 1.0 2.52341 Lung adenocarcinoma_LUAD_TCGA-44-2665-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QVJO-0011-R10A-SM-2S1QJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 CDK8_knockdown_147_GSE32108 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -4.0681 Sarcoma_SARC_TCGA-IF-A4AJ-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Keratoconus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.178 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE135030_3_v_0_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239688_2_v_5_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1591 GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles 1.0 1.26346 GSE88819_3_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE117212,GSE117214_0_v_1_zbtb1_human RummaGEO Gene Perturbation Signatures -1.0 null layer 4 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09805 Plant vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.142 SNU503 CCLE Cell Line Gene Expression Profiles 1.0 1.55205 GSE184892_4_v_1_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S7SF-1426-SM-4AT5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.893268 AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.500337 Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211126_3_v_0_hapln1_mouse RummaGEO Gene Perturbation Signatures -1.0 null LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207239 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.40347 H3K9me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 AFTPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48316 POLR2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74357 FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257822 Perturb_11224_KO_Slc39a8_SRP308366 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.295452 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971861 GSE174701_4_v_3_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null Central nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.312 Urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCFC1 ENCODE Transcription Factor Targets 1.0 null lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01867 GSE174701_5_v_8_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null H3K9me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE226249_5_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null SKMM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.60828 KDM1A_KD_GDS5055_457_mouse_adipose tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YV-0008-SM-4E3HP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838436 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE145639_7_v_6_adar_human RummaGEO Gene Perturbation Signatures -1.0 null UHRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02556 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null thorax TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GNG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20211 GSE60367_2_v_1_cxcr4_mouse RummaGEO Gene Perturbation Signatures 1.0 null MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1906 MYC-19915707-AK7-human ChEA Transcription Factor Binding Site Profiles 1.0 null PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null ZNF652 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5431 GTEX-QCQG-1726-SM-3GIJ9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29879 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20729 GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 NKM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE202434,GSE202438_15_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null BLUE1 DepMap CRISPR Gene Dependency 1.0 10.894 Perturb_14785_KO_Cdk7a_SRP257907 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.39347 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of mental health GWASdb SNP-Disease Associations 1.0 0.043932 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.351573 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null MEL-JUSO COSMIC Cell Line Gene Mutation Profiles 1.0 null FOXO1::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.8936 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE178714_6_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WZTO-0011-R10B-SM-4E3KB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Lung squamous cell carcinoma_LUSC_TCGA-34-5241-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null FGFR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04344 Paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65194 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.905783 GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE118617,GSE118619_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE80098,GSE80366_0_v_8_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15921 LN18 CCLE Cell Line Gene CNV Profiles 1.0 1.59216 GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XBEC-0008-SM-4AT3X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE193402_0_v_4_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE168918_1_v_0_tmprss4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210101,GSE210114_0_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-4073-01B-02R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_3_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_2486_Mut_ESR1_SRP254635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.66034 Uvula (IX), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.87901 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.730364 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 hsa-miR-194 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GTEX-WY7C-2126-SM-3NB2R GTEx Tissue Sample Gene Expression Profiles 1.0 1.33134 Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BB-62-MS83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348275 hsa-miR-1224-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC1954 CCLE Cell Line Gene CNV Profiles 1.0 1.43311 SW1463 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE229698_1_v_2_traf7_mouse RummaGEO Gene Perturbation Signatures 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE151412_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QDT8-0011-R4A-SM-32PKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 liminal part of alar p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09482 GTEX-U8XE-0226-SM-4E3J3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44852 CENPJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62373 superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0986 embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_5_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null KC-45-DZ26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.304107 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09419 ZNF384 ENCODE Transcription Factor Targets 1.0 null callosal sling Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25716 Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skin_5e HPA Tissue Sample Gene Expression Profiles 1.0 2.07993 abnormal cornea morphology IMPC Knockout Mouse Phenotypes 1.0 null GTEX-U3ZH-2026-SM-3DB78 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15062 GTEX-WVLH-0011-R2A-SM-3MJFJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92289 Basolateral amygdalar nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28725 hsa-miR-103a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 FOXH1-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE96641_5_v_0_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null brain GTEx Tissue Gene Expression Profiles -1.0 -1.17931 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BCL6B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6021 hsa-miR-4717-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09385 GSE233679_12_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.67889 superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25633 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null ZFPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36792 H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IFI27L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01046 GSE233679_6_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5778 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3927 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-Q2AG-0011-R10A-SM-2HMLA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Autosomal Recessive Primary Microcephaly DisGeNET Gene-Disease Associations 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uvula (IX), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.88576 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE193993_0_v_3_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null Prdm14 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.9322 OPTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47038 GSE119978,GSE180930_2_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A375SKINCJ3 DepMap CRISPR Gene Dependency 1.0 3.40914 Perturb_12557_KO_Aire_SRP033579 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.87658 Frontal pole, cerebral cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8249 GTEX-U8XE-0326-SM-3DB8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.52341 CHEK1_knockdown_136_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.33116 GSE233049_2_v_0_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE189356_5_v_6_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T6MN-0011-R2A-SM-32QOW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Thorax TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 steroid dehydrogenase activity GO Molecular Function Annotations 2015 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null GSE149123,GSE149128_1_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214931_2_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.60164 Nucleus taeniae TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.232 SW620 CCLE Cell Line Gene CNV Profiles 1.0 1.88675 ZEB1 ENCODE Transcription Factor Targets 1.0 null Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6809 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11867 ES-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04733 ZNF599 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6036 liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 hsa-miR-3688-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8704 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36694 Entorhinal area, medial part, ventral zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29878 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00736 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35663 primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14198 Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0986 GSE215351,GSE215794_1_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XMK1-0226-SM-4B65D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE233049_1_v_0_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE77108_3_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GSE202434,GSE202438_15_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.563598 NDUFAF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27486 GSE195559_6_v_7_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null DMAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0347 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Nucleus of the trapezoid body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2462 EGR1-23403033-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null skin HPA Tissue Gene Expression Profiles 1.0 1.54734 Perturb_528_KO_NFE2L1_SRP333364 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.93257 NANOG-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.74968 Prostate adenocarcinoma_PRAD_TCGA-CH-5789-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3666 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847667 NDFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13256 GSE193258,GSE193259_5_v_1_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE240386,GSE242143_1_v_4_morc2_human RummaGEO Gene Perturbation Signatures 1.0 null outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.92961 Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19238 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46123 GSE48812_7_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null EIF4E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84147 ventrolateral part of alar p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0986 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03293 GTEX-X4XY-0226-SM-4E3IZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.35879 MANSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00812 Carcinoma, Hepatocellular_Hepatic Tissue_GSE4612 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.24752 GSE198380_0_v_1_phgdh_human RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null retroreuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01297 Kdm1a_KD_GDS5055_275_mouse_3T3-L1 preadipocytes - 48h GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-SSA3-0126-SM-32QPU GTEx Tissue Sample Gene Expression Profiles 1.0 1.24102 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PECAPJ49 CCLE Cell Line Gene Expression Profiles 1.0 1.35965 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 1.66696 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0426-SM-32PLO GTEx Tissue Sample Gene Expression Profiles 1.0 1.26151 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 r6 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.4013 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.7773 RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.899039 LUC7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29021 FU97 CCLE Cell Line Gene CNV Profiles 1.0 1.33563 OVMANA CCLE Cell Line Gene CNV Profiles -1.0 -1.43668 GSE179036_1_v_0_trim24_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6968 GSE119603_1_v_0_oxaliplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE138001_2_v_3_rorb_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE210101,GSE210114_1_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 LXR-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-XYKS-1426-SM-4BRUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.45631 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216538_0_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRC-2_Deficiency_GDS5087_270_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ERF::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.75 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03055 GTEX-VJYA-1126-SM-3GIJU GTEx Tissue Sample Gene Expression Profiles 1.0 1.62824 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE114284_2_v_0_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE216538_7_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7ME-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nr1h3::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.6044 ST486 CCLE Cell Line Gene CNV Profiles 1.0 1.93554 BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11332_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.91292 NDUFB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57415 H3K9me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC Rummagene Transcription Factor Associations 2026 1.0 null C6orf141 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80187 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QLQ7-1626-SM-2S1R8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23992 NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8137 AARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50495 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.87208 Adrenocortical carcinoma_ACC_TCGA-OR-A5JC-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15314 FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.994202 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_0_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null TE-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null dorsolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.48043 brain_3b HPA Tissue Sample Gene Expression Profiles -1.0 -1.46316 GSE174701_1_v_2_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE227592_10_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.456506 Primary visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26082 D283MED CCLE Cell Line Gene CNV Profiles -1.0 -1.7769 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5677 GTEX-X4XX-0011-R10B-SM-46MWO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.933885 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227592_4_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE223893_1_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_15385_KD_FGF13_SRP319157 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.46904 Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R53T-1326-SM-48FCQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.902893 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.866444 GTEX-QMR6-1426-SM-32PLA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 CRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29215 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20_vs_D1_815_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null RT4 CCLE Cell Line Gene Expression Profiles 1.0 1.76075 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-let-7i TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.906277 CIAO2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45926 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208162 organic cyclic compound biosynthetic process GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-8398-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10653 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60631 UBC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE205540_2_v_1_phloridzin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Psmb TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.742 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7753-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRO-0126-SM-2YUN4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10513 intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.4004 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-513a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.01437 Wing TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.258 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64352 GSE200839,GSE233826_2_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-01A-32R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.40143 Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-OXRP-0126-SM-3NB32 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43731 RARB-24833708-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2064 PMC3500769-srep00875-s3.xls-CEBP-Time_1_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null NCOA2_KO_GDS5087_24_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-WOFL-0126-SM-3MJG2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10055 ACHN CCLE Cell Line Gene CNV Profiles 1.0 1.42515 Plastid stroma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.609 hsa-miR-3913-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE146074_0_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE174701_1_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XQ3S-1426-SM-4BOPR GTEx Tissue Sample Gene Expression Profiles 1.0 1.26981 GSE193258,GSE193259_9_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE65617_5_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE92614_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XUW1-0426-SM-4BOOT GTEx Tissue Sample Gene Expression Profiles 1.0 1.18608 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EE-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135030_11_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.435081 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0162 H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TE-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null hsa-miR-4257 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 MM1S CCLE Cell Line Gene CNV Profiles -1.0 -1.348 Sarcoma_SARC_TCGA-FX-A3NK-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.70983 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.825466 intermediate stratum of PThE Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39226 Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05879 GTEX-XOTO-3026-SM-4B65M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825454 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE93156_1_v_0_idelalisib_human RummaGEO Drug Perturbation Signatures -1.0 null amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25079 Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89812 PAX5 ENCODE Transcription Factor Targets 1.0 null mantle zone of p2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09669 GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 1.36431 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPVG-2626-SM-4B669 GTEx Tissue Sample Gene Expression Profiles 1.0 1.46297 hsa-miR-10a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Posterolateral visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40671 NCI-H1436 COSMIC Cell Line Gene Mutation Profiles 1.0 null mantle zone of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05992 primary metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CMTM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26143 PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7SE-0011-R2A-SM-2XCDC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE135030_8_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null FOXO1::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.8129 PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X5EB-2226-SM-46MW4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.916821 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H6-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LEF1-29337183-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null GSE151412_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Ectorhinal area/Layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19948 CAL148 CCLE Cell Line Gene CNV Profiles -1.0 -1.9011 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.724615 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13798 GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-7523-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null lateral septal nucleus, intermediate part, periventricular Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21515 Inferior colliculus, dorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15041 abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.040633 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.4963 trochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27748 TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112860_3_v_2_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null liminal periaqueductal gray of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08895 CHAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52317 CAPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04318 H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHU-2826-SM-3MJG8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03982 CHD1 ENCODE Transcription Factor Targets 1.0 null GSE148010,GSE148120_3_v_2_tet2_human RummaGEO Gene Perturbation Signatures -1.0 null JUND ENCODE Transcription Factor Targets 1.0 null GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null ventral part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03531 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.7744 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE57871_6_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.622045 GSE148692,GSE148695_7_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Dorsal peduncular area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1996 KNS-81-FD COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE88819_7_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.46316 H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-1273d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 p3 part of the ZL core Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17785 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR 10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SNAPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23734 GTEX-QVJO-1626-SM-2S1QW GTEx Tissue Sample Gene Expression Profiles 1.0 1.16383 GTEX-VJWN-0126-SM-3GIK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20713 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.573239 oxidoreductase activity, acting on ch-oh group of donors GO Molecular Function Annotations 2015 1.0 null POM121C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48315 GSE174498,GSE174500_3_v_4_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null caudal putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56232 KIF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21715 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0121 RAB42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43168 GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 internal granular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12023 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.3274 PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab10_KDM5C-KD-up-DKD-rescued-Table_10_Up-regulated_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRK-0226-SM-3NB2G GTEx Tissue Sample Gene Expression Profiles 1.0 1.41254 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879643 GSE146074_10_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.13475 Primary somatosensory area, nose, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10991 GTEX-PVOW-0011-R1A-SM-32PL6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE77108_4_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.480695 GTEX-WZTO-0011-R4A-SM-3NMC7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 NCIH2030 CCLE Cell Line Gene CNV Profiles 1.0 2.27435 GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4784-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF784 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0042 Prostate adenocarcinoma_PRAD_TCGA-CH-5761-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHPG-2626-SM-3NMBR GTEx Tissue Sample Gene Expression Profiles 1.0 0.917736 GSE145215_0_v_1_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_15464_KI_ETV4_SRP402451 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.62542 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE148066,GSE157787_8_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Ectorhinal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04125 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8137 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25626 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.03474 RRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66031 GTEX-SE5C-1126-SM-4BRWZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.882275 496100405_TCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42236 GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Gene_Name_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null rostral subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.90618 VB-89-RG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.27211 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_2_v_8_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 496100376_FWM_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.136 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null ISHIKAWA(HERAKLIO)02ER- COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WHSE-0126-SM-3NMBT GTEx Tissue Sample Gene Expression Profiles 1.0 1.06994 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null OV7 CCLE Cell Line Gene CNV Profiles -1.0 -1.33391 SP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114883_0_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94412 FEV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03328 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SMAD4-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE74251_2_v_3_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE154337_0_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XLM4-3026-SM-4AT6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OLFML2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15072 Perturb_15443_KD_MED25_SRP212208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.72502 LIAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59108 NCCIT COSMIC Cell Line Gene Mutation Profiles 1.0 null umbilical cord TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOS::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.099 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE149035_2_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null Ventral posterolateral nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49198 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11867 KYSE450 CCLE Cell Line Gene Expression Profiles 1.0 1.82815 urinarybladder_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.09658 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 HMGB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21629 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01829 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, mouth, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61484 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE231799_2_v_1_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsal spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42585 GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303032 Prostate adenocarcinoma_PRAD_TCGA-CH-5746-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_9152_KD_DDX21_SRP327839 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.30185 Perturb_16478_OE_Klk6_SRP245408 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GSE135705_5_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null skin GTEx Tissue Gene Expression Profiles 1.0 1.35972 r1 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45425 H3K9me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE179880_1_v_5_e2f4_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4687-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.309288 GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1159 PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858741 GSE166169_1_v_3_elp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SF-1626-SM-3K2AY GTEx Tissue Sample Gene Expression Profiles 1.0 1.34496 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.173 GSE166004_5_v_4_pld1_mouse RummaGEO Gene Perturbation Signatures -1.0 null E2F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8849 GSE240027,GSE240030_1_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney Chromophobe_KICH_TCGA-KL-8346-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE175787_5_v_6_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE193993_5_v_3_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null COLO-783 COSMIC Cell Line Gene CNV Profiles -1.0 -3.24687 GTEX-WVLH-0011-R8A-SM-3MJFC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 Hindbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 mRNA_T_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null RBM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16694 hsa-miR-4782-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE240896,GSE240899_10_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null HOOK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7479 FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6741 GTEX-WXYG-2326-SM-4E3I6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37089 Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 hsa-miR-589 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 SMARCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05116 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null umbilical artery TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HSPB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17136 GSE120370_4_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null SP2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.55789 GTEX-X638-0126-SM-47JZ8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.979369 H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE255432_7_v_3_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Chloroplast stroma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 TE4 CCLE Cell Line Gene CNV Profiles 1.0 1.39221 HB-24-GP45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220001 hsa-let-7d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-XQ8I-0426-SM-4BOPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.30522 hsa-miR-130b TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 GSE128730_0_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null EWS-ERG-20517297-CADO-ES1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null OVKATE CCLE Cell Line Gene CNV Profiles -1.0 -1.35334 hsa-miR-3977 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 ZNF572 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16049 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.27196 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200839,GSE233826_3_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal cornea morphology MGI Mouse Phenotype Associations 2023 1.0 null body of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23804 MERO82 DepMap CRISPR Gene Dependency 1.0 5.35849 GTEX-R55E-0011-R1A-SM-2TC6N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE225656_0_v_1_tsc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.554811 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1092 COSMIC Cell Line Gene Mutation Profiles 1.0 null ventral linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21943 GTEX-WI4N-2726-SM-3LK7Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.18277 GSE216540_0_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE139239_3_v_6_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-1326-SM-48TD2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.871239 CESS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.537 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26867 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.50409 PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null RH-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null TFAP4::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4696 Pancreatic adenocarcinoma_PAAD_TCGA-YY-A8LH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MS-0011-R10A-SM-2HMJK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67747 GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE215086_3_v_0_batf_human RummaGEO Gene Perturbation Signatures 1.0 null HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.463257 GTEX-WK11-2726-SM-3NMAQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.27464 NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7701 REV3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21975 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GSE174498,GSE174500_3_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XX-0011-R2A-SM-3P623 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830676 trunk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11019 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.893304 GSE206516,GSE206518_0_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE167886_2_v_0_chd7_mouse RummaGEO Gene Perturbation Signatures -1.0 null BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7814 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WB-82-EL69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238854 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.14513 SEMA7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76293 GSE217441,GSE217443_1_v_0_ivosidenib_mouse RummaGEO Drug Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LS-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 3 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2102 GSE57871_6_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.1252 GSE167886_2_v_1_chd7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE255432_6_v_2_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Anteromedial nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03024 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5245 endoplasmic reticulum LOCATE Predicted Protein Localization Annotations 1.0 null GSE178532_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null ETS1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LGALS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57397 GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 medial superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29136 H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null layer 4 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55218 MZT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.7391 dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13947 hsa-miR-1251 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE202434,GSE202438_13_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00736 E2F4 ENCODE Transcription Factor Targets 1.0 null KML1 DepMap CRISPR Gene Dependency 1.0 2.96796 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 GTEX-TSE9-0011-R10A-SM-3DB7O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879153 FOXJ2::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.3101 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tcf21 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.2815 HCC38 CCLE Cell Line Gene Expression Profiles 1.0 1.63458 alzheimer's disease GWASdb SNP-Disease Associations 1.0 0.598827 H3K9ac_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19876 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50833 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07009 PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31047 GSE77108_0_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8268 H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE88819_5_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EIF5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93552 ALG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64317 DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.471323 H3K9me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52976 cardiovascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7327-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cognitive disorder GWASdb SNP-Disease Associations 1.0 0.10047 GTEX-WZTO-2826-SM-3NM8P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 CD-16-KY17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287827 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41529 GSE157594_0_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15546 TMEM205 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33986 JVM-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100426_PCx_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.12811 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nanog JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.3193 Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4386 SOX2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4003 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98593 Main olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32888 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WXYG-2026-SM-4E3IY GTEx Tissue Sample Gene Expression Profiles 1.0 1.17574 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.928764 cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-U3ZN-2326-SM-3DB7W GTEx Tissue Sample Gene Expression Profiles 1.0 1.19966 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE101239_4_v_1_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE175787_4_v_7_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE110178_4_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG231 DepMap CRISPR Gene Dependency 1.0 6.14085 AC-05-MR83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221831 EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303954 GK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71186 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO Molecular Function Annotations 2023 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Spinal Cord Injury_CNS - Spinal Cord (MMHCC)_GSE16710 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.6795 GTEX-PVOW-0126-SM-2XCFA GTEx Tissue Sample Gene Expression Profiles 1.0 2.08473 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35265 nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE175787_5_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26853 H3K4me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE104022_3_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12783 WAOSEL DepMap CRISPR Gene Dependency 1.0 3.64337 H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null